category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	32/537	232/9376	2.40827072497271	ITGAD/VAV3/IQGAP2/SOS1/RGCC/ACTB/CYFIP2/BRAF/ARHGEF1/ITGB5/SSH2/ITGA1/IQGAP1/ARHGEF7/ARPC5L/PIP4K2A/RRAS2/ITGAM/ARHGEF12/PFN1/PAK2/PIKFYVE/PPP1R12B/KRAS/ARHGEF6/TIAM1/ITGAL/ARPC1B/PIK3CB/ACTN4/ROCK2/ACTR2	5.35344381603544
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	33/537	250/9376	2.30471508379888	LITAF/BORCS5/OSBPL3/SLC15A4/GNPTAB/BORCS7/VPS13C/ACP5/CD164/NPC2/GPR155/VPS41/CTSK/WDR7/MANBA/ATP6V0A2/AP3B1/PIKFYVE/CTSD/ASAH1/CTSA/FUCA1/VAMP8/CTSZ/AP1S2/LAPTM4B/DMXL1/MFSD8/SORT1/IDS/ATP6V1A/ATP6V0C/AP2B1	5.15367074953396
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	22/537	133/9376	2.88811414009885	KLRC3/KLRC2/VAV3/KLRC1/HCST/SOS1/TYROBP/CASP3/BRAF/PPP3CA/LCP2/PRF1/HLA-C/KLRK1/LAT2/PLCG2/TNFRSF10A/PTPN6/ZAP70/KRAS/ITGAL/PIK3CB	5.40528755358052
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	14/537	75/9376	3.2591930477964	BCL2/CDKN2A/SERPINE1/CASP3/CDK6/CCND3/BAX/ATR/IGFBP3/TNFRSF10A/ZMAT3/CCNG1/MDM4/COP1	4.84161627847788
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	26/537	204/9376	2.22528937086939	MMP9/VAV3/LUM/SOS1/CAMK2D/CASP3/PRKACB/ACTB/BRAF/ARHGEF1/ITGB5/PLAUR/IQGAP1/CAMK2G/WNT4/RRAS2/PLCG2/HCLS1/ARHGEF12/PTPN6/WNT6/PPP1R12B/KRAS/TIAM1/PIK3CB/ROCK2	4.36106882774038
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/537	138/9376	2.53042938493509	VAV3/SKAP2/FYB1/GNAQ/RPS6KA3/ACTB/ARHGEF1/LCP2/NFATC3/ARHGEF7/ARPC5L/WAS/ELMO1/ARHGEF12/ZAP70/ARPC1B/PIK3CB/ROCK2/ACTR2/MAP2K4	4.46411191802224
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	26/537	216/9376	2.10166218359887	APOA1/BCL2/MMP9/ERN1/LDLR/VAV3/CAMK2D/CASP3/NFE2L2/ARHGEF1/PPP3CA/POU2F1/CAMK2G/NFATC3/BAX/JAK2/CCL3/TNFRSF10A/IRF7/HSPA4/RAP1B/KRAS/PIK3CB/ROCK2/EIF2AK3/MAP2K4	4.03737225907077
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	28/537	250/9376	1.95551582867784	VPS37B/LDLR/PLD1/ITCH/EPS15/SMAP2/RAB11FIP1/HLA-C/ACAP2/VPS45/ARPC5L/ARAP2/ARFGEF1/WASHC1/WASHC4/PDCD6IP/CYTH1/RAB31/WWP1/STAM2/ARPC1B/STAM/ACTR2/CHMP5/RABEP1/CYTH2/SMAP1/AP2B1	3.77432133507301
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/537	20/9376	5.23798882681564	SQLE/MSMO1/FDFT1/DHCR24/CYP51A1/SOAT1	4.67628436496186
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	15/537	104/9376	2.51826385904598	PLD1/SGMS1/PLPP3/SELENOI/LCLAT1/DGKE/ETNK1/AGPAT5/CHKA/AGPAT4/LPIN1/GPD2/PLPP1/LPIN2/CEPT1	3.83750033519679
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	21/537	173/9376	2.11941744437627	MX1/EIF2AK2/CASP3/ACTB/RSAD2/PRSS3/CDK6/CCND3/KPNA1/BAX/ADAR/OAS1/JAK2/OAS2/PABPN1/TNFRSF10A/IRF9/IRF7/TRIM25/OAS3/PIK3CB	3.66287101051045
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/537	212/9376	1.97659955728892	VAV3/ADCY9/FYB1/GNAQ/ACTB/BRAF/SKAP1/LCP2/CSF1/SIPA1L1/LPAR3/PRKD3/RAPGEF6/ITGAM/PFN1/ADCY7/RAP1B/EFNA5/RASGRP2/KRAS/TIAM1/PRKD2/ITGAL/PIK3CB	3.54497459674534
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/537	142/9376	2.21323471555591	ITCH/CUL1/HERC4/BIRC6/MAP3K1/HERC1/FBXW8/PIAS1/UBE2W/CDC27/WWP1/UBE2K/FANCL/UBE2J1/HERC3/UBA3/UBA6/COP1	3.59058555951596
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/537	120/9376	2.32799503414029	BCL2/SOS1/CAMK2D/RPS6KA3/BRAF/CAMK2G/BAX/MAP3K1/PLCG2/RAP1B/RPS6KA5/KRAS/SORT1/PIK3CB/MATK/ARHGDIB	3.60866539672625
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	14/537	99/9376	2.46908564227	BCL2/MMP9/CDKN2A/SOS1/ADCY9/PRKACB/BRAF/BAX/NOTCH2/ADCY7/KRAS/PIK3CB/NCOA3/NCOR1	3.62186407295581
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	22/537	193/9376	1.9902548219334	VAV3/SOS1/ADCY9/CCR1/PRKACB/GNAQ/BRAF/ITK/WAS/JAK2/CCL3/ELMO1/PLCG2/ADCY7/RAP1B/RASGRP2/CCL8/KRAS/TIAM1/PIK3CB/ROCK2/DOCK2	3.42613555855642
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	16/537	122/9376	2.28983118112159	VAV3/PTPRC/SOS1/DLG1/PPP3CA/ITK/LCP2/NFATC3/PPP2R5C/PAK2/PTPN6/NCK1/ZAP70/KRAS/MALT1/PIK3CB	3.53442893114331
Organismal Systems	Immune system	hsa04611	Platelet activation	16/537	126/9376	2.21713812775265	STIM1/ADCY9/PRKACB/GNAQ/ACTB/ARHGEF1/LCP2/PLCG2/ARHGEF12/ADCY7/RAP1B/RASGRP2/VAMP8/PIK3CB/SNAP23/ROCK2	3.3902013113047
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/537	33/9376	3.703628463405	STX3/STX8/VTI1A/VAMP8/SNAP23/STX2/STX16	3.83470552861286
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/537	93/9376	2.44063995514707	YES1/ACTB/FER/IQGAP1/NLK/WAS/PTPN1/NECTIN3/PTPN6/RAP1B/LEF1/ACTN4/ROCK2	3.44131136391018
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/537	200/9376	1.92059590316574	MYO1F/CASP3/ACTB/CYFIP2/ARHGEF1/BAX/ABI1/ARPC5L/TMED10/HCLS1/ARHGEF12/TNFRSF10A/PAK2/PTPN6/CYTH1/SEC24B/NCK1/ARPC1B/ROCK2/ACTR2/SEC24D/CYTH2	3.2436093777058
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/537	116/9376	2.25775380466191	MMP9/VAV3/THY1/ACTB/ITK/CD99/ITGAM/PLCG2/PECAM1/RAP1B/ITGAL/PIK3CB/ACTN4/ROCK2/ARHGAP5	3.35962152491328
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/537	122/9376	2.14671673230149	ATP1B3/NCOA1/PRKACB/ACTB/NCOA2/KAT2B/WNT4/NOTCH2/PLCG2/MED13L/KRAS/PIK3CB/NCOA3/NCOR1/SLC16A10	3.14226299828492
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	11/537	78/9376	2.46230243995607	PIP4K2A/INPP5B/PI4KA/MTM1/PLCG2/PIKFYVE/PI4K2B/MTMR1/SACM1L/PIK3C2A/PIK3CB	3.19639872800291
NA	NA	hsa04517	IgSF CAM signaling	28/537	299/9376	1.63504667949652	VAV3/CASK/ACTB/CABLES1/SRGAP2/LCP2/IQGAP1/MTSS1/RASA1/MBP/ARPC5L/RAPGEF6/NFASC/ITGAM/PLCG2/PAK2/NECTIN3/PTPN6/RAP1B/NCK1/ERC1/NCAM1/CD96/ITGAL/ARPC1B/PIK3CB/ACTN4/ACTR2	2.75068772932071
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/537	180/9376	1.84299606869439	BCL2/SP100/EIF2AK2/BST2/CASP3/ZC3HAV1/B2M/POU2F1/HLA-C/BAX/CD74/OAS1/JAK2/OAS2/IRF9/IRF7/C3/OAS3/PIK3CB	2.81470921311589
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/537	156/9376	1.90268824905696	LDLR/MX1/EIF2AK2/SOS1/CASP3/RSAD2/BRAF/CDK6/BAX/OAS1/OAS2/PIAS1/IRF9/IRF7/KRAS/OAS3/PIK3CB	2.80224331456853
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	24/537	248/9376	1.68967381510182	BCL2/PTPRC/CASP3/ACTB/CYFIP2/KPNA1/BAX/ABI1/ARPC5L/VPS41/ELMO1/MLKL/TNFRSF10A/PFN1/CYTH1/LEF1/EXOC4/PIK3C2A/ARPC1B/PIK3CB/ROCK2/ACTR2/CYTH2/MAP2K4	2.71301988060533
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	18/537	170/9376	1.84870193887611	CDKN2A/DPF3/SOS1/ACTB/BRAF/NFE2L2/CDK6/ARID1B/WNT4/BAX/SMARCA2/PLCG2/WNT6/MGST2/KRAS/LEF1/PIK3CB/GSTP1	2.75242430283373
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	17/537	158/9376	1.8786035876765	CDKN2A/CCNH/ATRX/CDKN1C/CDK6/CCND3/NIPBL/CUL1/PDS5B/ATR/PPP2R5C/PDS5A/STAG1/CDC27/PCNA/ESCO1/HDAC8	2.74520245123633
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	22/537	224/9376	1.71481777068369	CDKN2A/ADCY9/PRKACB/DLG1/B2M/PPP3CA/KAT2B/CCND3/HLA-C/NFATC3/BAX/ATR/MAP3K1/IL1R2/ZFP36/ADCY7/CDC27/KRAS/ITGAL/PIK3CB/MAP2K4/CRTC3	2.66890157680799
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/537	86/9376	2.23325105019272	SOS1/AREG/CAMK2D/BRAF/CAMK2G/PLCG2/PAK2/NCK1/KRAS/PIK3CB/MAP2K4	2.83180977593938
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/537	98/9376	2.13795462319006	DGKE/PIP4K2A/INPP5B/PI4KA/MTM1/PLCG2/PIKFYVE/PI4K2B/MTMR1/SACM1L/PIK3C2A/PIK3CB	2.79114251769099
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/537	76/9376	2.29736352053318	CDKN2A/SOS1/CAMK2D/BRAF/CDK6/CAMK2G/BAX/PLCG2/KRAS/PIK3CB	2.79896983595785
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	16/537	149/9376	1.87489532950895	SOS1/ADCY9/PLD1/PLPP3/DGKE/LPAR3/AGPAT5/AGPAT4/RRAS2/PLCG2/PLPP1/ADCY7/CYTH1/KRAS/PIK3CB/CYTH2	2.65332339380667
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	27/537	300/9376	1.57139664804469	RASA2/PPM1B/SOS1/AREG/CASP3/PRKACB/RPS6KA3/BRAF/PPP3CA/CSF1/NFATC3/RASA1/MAP4K3/MAP3K1/NLK/RRAS2/PAK2/TAOK1/MAP3K21/RAP1B/RPS6KA5/EFNA5/RASGRP2/KRAS/MAP4K4/MAPKAPK3/MAP2K4	2.47926121372178
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	15/537	139/9376	1.88416864273944	BCL2/MMP9/NCOA1/SOS1/ADCY9/PRKACB/GNAQ/FKBP5/NCOA2/KRT23/ADCY7/CTSD/KRAS/PIK3CB/NCOA3	2.58850048623152
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/537	67/9376	2.34536813140999	CAMK2D/PRKACB/GNAQ/RPS6KA3/BRAF/PPP3CA/CAMK2G/RAP1B/KRAS	2.72394438533414
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	20/537	205/9376	1.70341100059045	SP100/CDKN2A/RASA2/EIF2AK2/CASP3/PRKACB/DLG1/KAT2B/CDK6/CCND3/HDAC9/HLA-C/BAX/IRF9/IRF7/KRAS/C3/PIK3CB/ACTN4/HDAC8	2.50985685976634
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/537	93/9376	2.06515688512445	SOS1/ADCY9/CAMK2D/PLD1/PRKACB/GNAQ/CAMK2G/MAP3K1/ADCY7/KRAS/MAP2K4	2.54438069694639
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	17/537	170/9376	1.74599627560521	PRKACB/PATJ/ACTB/DLG1/ARPC5L/MAP3K1/RAPGEF6/WAS/HCLS1/HSPA4/TIAM1/PCNA/RUNX1/ARPC1B/ACTN4/ROCK2/ACTR2	2.4193396818656
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	18/537	184/9376	1.70803983483119	CAMK2D/SEMA3B/PPP3CA/SSH2/SRGAP2/CAMK2G/NFATC3/WNT4/SEMA3A/RASA1/PLCG2/ARHGEF12/PAK2/NCK1/EFNA5/KRAS/PIK3CB/ROCK2	2.39074254314436
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/537	122/9376	1.86048783466129	SOS1/ADCY9/PRKACB/GNAQ/MAP3K1/JAK2/PLCG2/IGFBP3/ADCY7/SOCS2/KRAS/PIK3CB/MAP2K4	2.35793113256814
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/537	73/9376	2.15259814800643	CDKN2A/SOS1/EML4/BRAF/CDK6/BAX/PLCG2/KRAS/PIK3CB	2.43668309951023
Human Diseases	Infectious disease: viral	hsa05162	Measles	14/537	136/9376	1.79734910724066	BCL2/MX1/EIF2AK2/CASP3/CDK6/CCND3/BAX/ADAR/OAS1/OAS2/IRF9/IRF7/OAS3/PIK3CB	2.30862394041678
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/537	98/9376	1.95979173792422	VAV3/PTPRC/PLD1/PLPP3/ARPC5L/WAS/PLCG2/PLPP1/ARPC1B/PIK3CB/ACTR2	2.35414969389459
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/537	98/9376	1.95979173792422	ATP1B3/LDLR/ADCY9/CAMK2D/PRKACB/GNAQ/CAMK2G/PRKD3/ADCY7/PRKD2/ATP2B1	2.35414969389459
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/537	62/9376	2.25289842013576	TLE1/ITCH/MAML3/KAT2B/DTX3L/NOTCH2/NUMB/SPEN	2.43957853590107
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/537	137/9376	1.78422977069146	BCL2/ERN1/CASP3/ACTB/PRF1/BAX/PARP4/CTSK/TNFRSF10A/CTSD/KRAS/CTSZ/PIK3CB/EIF2AK3	2.27909453089265
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/537	51/9376	2.39646547632088	ADCY9/PRKACB/ACTB/ATP6V0A2/PLCG2/ATP6V1A/ATP6V0C	2.46468876478435
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	19/537	205/9376	1.61824045056093	BCL2/ISG15/EIF2AK2/CASP3/CD58/B2M/CDK6/CCND3/HLA-C/BAX/OAS1/OAS2/PLCG2/IRF9/IRF7/OAS3/ITGAL/PIK3CB/MAP2K4	2.20595787458949
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/537	87/9376	2.00689227081059	BCL2/SOS1/AREG/CASP3/BRAF/BAX/KRAS/LEF1/MSH3/PIK3CB	2.3255697306543
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/537	63/9376	2.21713812775265	ASH1L/SMYD3/CAMKMT/EHMT1/NSD2/SETD2/KMT2A/NSD1	2.38911224708717
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/537	52/9376	2.35037960177625	APOA1/LDLR/NPC2/APOC1/SORT1/VAPA/SOAT1	2.40673139133597
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/537	65/9376	2.14891849305257	PLPP3/LCLAT1/DGKE/AGPAT5/AGPAT4/LPIN1/PLPP1/LPIN2	2.29096760946351
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/537	115/9376	1.82190915715327	BCL2/MEF2A/ADCY9/PLD1/PRKACB/STK39/GNAQ/BRAF/ARHGEF1/BGLAP/WNK1/ADCY7	2.18582309973102
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	18/537	196/9376	1.60346596739254	EIF2AK2/CASP3/CCR1/PPP3CA/CDK6/HLA-C/NFATC3/BAX/JAK2/ZFP36/PLCG2/IRF9/IRF7/KRAS/LEF1/C3/PIK3CB/MAP2K4	2.10441162470266
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/537	155/9376	1.68967381510182	CDKN2A/LDLR/ADCY9/CAMK2D/PRKACB/GNAQ/BRAF/CDK6/CAMK2G/WNT4/ADCY7/WNT6/RAP1B/LEF1/KMT2A	2.13398709905629
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	22/537	253/9376	1.51825763096106	BCL2/SEPTIN7/ACTB/CUL1/BAX/SEPTIN6/ARPC5L/ELMO1/PLCG2/HCLS1/PFN1/CYTH1/RPS6KA5/MALT1/C3/ARPC1B/PIK3CB/ACTN4/GLMN/ROCK2/ACTR2/CYTH2	2.05972074315774
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/537	91/9376	1.9186772259398	VAV3/SOS1/PPP3CA/PIK3AP1/NFATC3/PLCG2/PTPN6/KRAS/MALT1/PIK3CB	2.17052057274107
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	15/537	157/9376	1.66814930790307	VPS8/CAMK2D/CASP3/ATP8A1/CD47/ITGB5/CAMK2G/NFATC3/VPS41/XKR6/JAK2/ELMO1/PECAM1/ADAM10/PTPN6	2.08090692604844
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	20/537	227/9376	1.53832270978433	CDKN2A/SOS1/ADCY9/CASP3/CCR1/PRKACB/GNAQ/ARHGEF1/B2M/PPP3CA/CDK6/HLA-C/NFATC3/BAX/CCL3/ARHGEF12/ADCY7/KRAS/PIK3CB/ROCK2	2.02367156946861
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	27/537	333/9376	1.41567265589612	ISG15/MX1/EIF2AK2/SOS1/CASP3/PRKACB/PATJ/MAML3/DLG1/ITGB5/ITGA1/CDK6/CCND3/HLA-C/WNT4/BAX/NOTCH2/ATR/NFX1/PPP2R5C/ATP6V0A2/IRF9/WNT6/KRAS/PIK3CB/ATP6V1A/ATP6V0C	1.90365621824239
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/537	82/9376	1.91633737566426	KLRC3/KLRC2/KLRC4/KLRC1/B2M/HLA-C/PSME2/CD74/HSPA4	2.05415025225043
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/537	108/9376	1.77832953996827	KPNA1/XPO6/RANBP2/IPO11/KPNB1/NUP210/RANBP17/NUP58/UPF2/NUP133/UPF3A	2.00518105548219
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/537	70/9376	1.99542431497739	CASP3/ACTB/PRF1/HLA-C/SNTB1/ITGAL/EIF4G3/DAG1	2.06037824176238
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	15/537	163/9376	1.6067450389005	BCL2/MMP9/SOS1/CASP3/STAT4/BRAF/NFATC3/BAX/MAP3K1/JAK2/IRF7/KRAS/PCNA/PIK3CB/MAP2K4	1.92606400338009
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/537	83/9376	1.89324897354782	CASP3/SAMHD1/IFI16/ZBP1/POLR3GL/ADAR/POLR2K/MLKL/IRF7	2.01467416591547
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	16/537	178/9376	1.5694348544766	TLE1/CAMK2D/PRKACB/INVS/PPP3CA/LGR4/CCND3/CUL1/CAMK2G/NFATC3/WNT4/TBL1XR1/NLK/WNT6/LEF1/ROCK2	1.8905081717376
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/537	110/9376	1.74599627560521	ADCY9/PRKACB/RPS6KA3/STK10/BRAF/SPDYE2/ADCY7/SPDYA/CDC27/KRAS/PIK3CB	1.93980497131945
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	13/537	138/9376	1.64477910020781	ADCY9/CAMK2D/PRKACB/RPS6KA3/PPP3CA/CUL1/CAMK2G/PPP2R5C/SPDYE2/ADCY7/SPDYA/CDC27/SLK	1.88075718753362
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	12/537	125/9376	1.67615642458101	BCL2/PLD1/SGMS1/SPTSSB/GNAQ/BAX/PPP2R5C/CTSD/ASAH1/KRAS/PIK3CB/ROCK2	1.87576772510873
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	16/537	181/9376	1.54342212208196	BCL2/CAMK2D/CASP3/PPP3CA/CAMK2G/BAX/CD74/ITGAM/JAK2/ATP6V0A2/ARHGEF12/CTSD/MALT1/C3/ATP6V0C/CORO1A	1.81958332747794
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/537	73/9376	1.91342057600571	MX1/BST2/SAMHD1/KAT2B/RANBP2/MDFIC/PDCD6IP/CPSF6	1.9310429087082
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/537	99/9376	1.76363260162143	SOS1/PLD1/PLPP3/SLC44A1/DGKE/CHKA/WAS/PLPP1/KRAS/PIK3CB	1.88264959180788
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/537	168/9376	1.55892524607608	PRL/BCL2/SOS1/OSM/STAT4/CCND3/PRLR/JAK2/PIAS1/IRF9/PTPN6/SOCS2/STAM2/PIK3CB/STAM	1.80175993866499
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/537	101/9376	1.72870918376754	ADCY9/CAMK2D/PRKACB/GNAQ/CAMK2G/WNT4/ADCY7/WNT6/KRAS/LEF1	1.81480173055812
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/537	75/9376	1.86239602731223	BCL2/CDKN2A/CASP3/BAX/MGST2/MSH3/PIK3CB/GSTP1	1.84817789183717
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/537	115/9376	1.67008339405716	BCL2/KCNQ5/ADCY9/CAMK2D/PRKACB/GNAQ/CAMK2G/JAK2/ADCY7/KRAS/PIK3CB	1.78205066670546
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	18/537	214/9376	1.46859499817261	BCL2/BST2/CASP3/GNAQ/SAMHD1/B2M/PPP3CA/CUL1/HLA-C/NFATC3/BAX/ATR/PLCG2/PAK2/TNFRSF1B/KRAS/AP1S2/PIK3CB	1.70915167766269
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/537	76/9376	1.83789081642654	ATP1B3/ADCY9/CAMK2D/PRKACB/GNAQ/ACTB/CAMK2G/ADCY7	1.80769004514646
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/537	77/9376	1.8140221045249	CDKN2A/PLD1/BRAF/CDK6/BAX/KRAS/ARHGEF6/PIK3CB	1.76780619309861
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/537	77/9376	1.8140221045249	CDKN2A/SOS1/BRAF/CDK6/BAX/KRAS/RUNX1/PIK3CB	1.76780619309861
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	15/537	174/9376	1.50516920310794	BCL2/MAN1A1/ERN1/NFE2L2/CUL1/BAX/MAGT1/MOGS/SSR4/SEC24B/DNAJC1/UBE2J1/NGLY1/EIF2AK3/SEC24D	1.65783609244196
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/537	78/9376	1.79076541087714	ACTB/SEPTIN6/ARPC5L/ELMO1/HCLS1/ARPC1B/PIK3CB/ACTR2	1.72850805990061
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/537	53/9376	1.97659955728892	ATP1B3/ADCY9/PRKACB/GNAQ/ATP2B1/AP2B1	1.75730777234228
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/537	106/9376	1.64716629774077	BCL2/MMP9/SOS1/BRAF/IL1R2/KRAS/ZEB1/LEF1/PIK3CB/GSTP1	1.6515821187978
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/537	41/9376	2.12926375073807	MMP9/CDKN2A/BRAF/RPS6KA5/KRAS	1.78608189785105
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/537	80/9376	1.74599627560521	BCL2/SOS1/BRAF/BAX/JAK2/PLCG2/KRAS/PIK3CB	1.65159975329625
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/537	68/9376	1.79734910724066	SOS1/BRAF/ITGAM/KRAS/LEF1/RUNX1/PIK3CB	1.62646976875663
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/537	69/9376	1.77130056945457	VAV3/SOS1/LCP2/PLCG2/KRAS/PIK3CB/MAP2K4	1.58494630789677
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/537	56/9376	1.8707102952913	MAN1A1/FUT8/MGAT5/MAGT1/MOGS/B4GALT1	1.61076042572814
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/537	83/9376	1.68288797648695	SFMBT2/SFMBT1/LCOR/MBD5/L3MBTL4/AUTS2/DCAF7/AEBP2	1.54021645161051
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/537	97/9376	1.61999654437597	ADCY9/CAMK2D/PRKACB/GNAQ/CAMK2G/NOS1AP/ADCY7/RPS6KA5/PER3	1.51284962793146
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/537	169/9376	1.44638744724692	BCL2/ERN1/PRKACB/BIRC6/VPS41/RRAS2/RUBCN/UVRAG/CTSD/HMGB1/KRAS/VAMP8/PIK3CB/EIF2AK3	1.44333608048656
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/537	44/9376	1.98408667682411	MAN1A1/FUT8/B4GALNT3/MAGT1/B4GALT1	1.61266269371584
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/537	44/9376	1.98408667682411	CCNH/MNAT1/TAF15/GTF2I/TAF2	1.61266269371584
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/537	32/9376	2.18249534450652	BCL2/CASP3/BAX/BIRC6	1.65150247154467
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/537	10/9376	3.49199255121043	PAPSS1/SQOR	1.94330459342226
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/537	71/9376	1.7214047787657	PRL/SOS1/PRLR/JAK2/SOCS2/KRAS/PIK3CB	1.50390780966724
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/537	71/9376	1.7214047787657	CASP3/ATP6V0A2/PLCG2/ADAM10/ATP6V1A/ATP6V0C/MAP2K4	1.50390780966724
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/537	85/9376	1.64329061233432	ADK/AMPD3/CDA/NT5C/NME7/CMPK1/NUDT16/CMPK2	1.46844153688495
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/537	99/9376	1.58726934145929	ADCY9/CAMK2D/PRKACB/GNAQ/PRKCH/CAMK2G/PLCG2/ADCY7/PIK3CB	1.44784597152089
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/537	142/9376	1.4754898103706	BCL2/MMP9/MEF2A/ACTB/NFE2L2/IL1R2/KLF2/PECAM1/MGST2/PIK3CB/GSTP1/MAP2K4	1.40721892056261
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/537	157/9376	1.44572940018266	CDKN2A/SERPINE1/PPP3CA/CDK6/CCND3/HLA-C/NFATC3/ATR/HIPK1/RRAS2/IGFBP3/KRAS/PIK3CB	1.38819480168955
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/537	158/9376	1.43657921410556	SOS1/RPS6KA3/BRAF/WNT4/LPIN1/WNT6/MAPKAP1/KRAS/LPIN2/PIK3CB/CAB39L/ATP6V1A/DEPDC5	1.36409450807147
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/537	59/9376	1.77558943281886	DPYD/CDA/NT5C/NME7/CMPK1/CMPK2	1.47296034687225
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/537	59/9376	1.77558943281886	SOS1/BRAF/BAX/KRAS/LEF1/PIK3CB	1.47296034687225
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/537	203/9376	1.37615469998441	BCL2/VAV3/SOS1/ACTB/BRAF/ITGB5/ITGA1/CCND3/PAK2/RAP1B/PPP1R12B/PARVB/PIK3CB/ACTN4/ROCK2/ARHGAP5	1.33545736919841
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/537	88/9376	1.58726934145929	SERPINE1/CLU/SERPING1/PLAUR/ITGAM/CFH/TFPI/C3	1.36423370723036
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	12/537	148/9376	1.41567265589612	NCOA1/SOS1/BRAF/CDK6/WNT4/BAX/NOTCH2/WNT6/KRAS/LEF1/PIK3CB/NCOA3	1.25631844262928
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/537	23/9376	2.27738644644158	REN/LNPEP/CTSA	1.5117569322042
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/537	90/9376	1.55199668942686	ADCY9/PRKACB/BAX/ADCY7/EHMT1/KRAS/PIK3CB/ADIPOR2	1.29692422439982
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/537	90/9376	1.55199668942686	EML4/PPP3CA/NFATC3/JAK2/PTPN6/ZAP70/KRAS/PIK3CB	1.29692422439982
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/537	105/9376	1.49656823623304	MFN1/RRAS2/USP15/CITED2/CCZ1/KRAS/RHOT1/MTX2/EIF2AK3	1.26119287587619
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/537	105/9376	1.49656823623304	PPP3CA/NFATC3/RRAS2/PLCG2/ARHGEF12/IRF9/KRAS/MALT1/PIK3CB	1.26119287587619
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/537	37/9376	1.88756354119483	BRAF/BAX/KRAS/LEF1	1.33327993303711
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/537	51/9376	1.71176105451492	PLD1/PLPP3/SELENOI/PLPP1/CEPT1	1.25622115549591
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/537	168/9376	1.35106854659927	BCL2/EIF2AK2/CAMK2D/STAT4/CAMK2G/ZBP1/BAX/JAK2/MLKL/TNFRSF10A/IRF9/HMGB1/CHMP5	1.13170991546481
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/537	154/9376	1.36051657839367	BCL2/ATP1B3/ADCY9/CAMK2D/PRKACB/GNAQ/CREM/CAMK2G/PPP2R5C/ADCY7/RPS6KA5/ATP2B1	1.1118450225159
NA	NA	hsa04518	Integrin signaling	12/537	154/9376	1.36051657839367	ITGAD/ACTB/ITGB5/ITGA1/CCND3/ITGAM/PARVB/C3/ARHGEF6/ITGAL/PIK3CB/ACTN4	1.1118450225159
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/537	154/9376	1.36051657839367	ADCY9/CAMK2D/PRKACB/GNAQ/ACTB/PPP3CA/CAMK2G/NFATC3/ADCY7/PPP1R12B/KRAS/ROCK2	1.1118450225159
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/537	95/9376	1.47031265314123	CSF1/ACP5/CTSK/CCL3/ATP6V0A2/ITGAL/ATP6V1A/ATP6V0C	1.13559191914477
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/537	14/9376	2.49428039372173	FUT8/B4GALT1	1.37905952330703
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/537	55/9376	1.58726934145929	SGMS1/PLPP3/B4GALT6/PLPP1/ASAH1	1.07661055638037
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/537	160/9376	1.30949720670391	PTPRC/CD58/CD99/HLA-C/GLG1/NFASC/ITGAM/PECAM1/NECTIN3/NCAM1/ITGAL/SPN	0.973232730509736
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/537	15/9376	2.32799503414029	SLC33A1/ST3GAL5	1.26868022941725
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/537	70/9376	1.49656823623304	SOS1/BRAF/PAK2/RAP1B/KRAS/PIK3CB	1.02782137636262
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/537	28/9376	1.8707102952913	ATP6V0A2/ATP6V1A/ATP6V0C	1.13727255174384
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/537	56/9376	1.55892524607608	BCL2/PRKACB/CUL1/CSNK1G1/GAS1	1.03397728519854
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/537	101/9376	1.38296734701403	BCL2/SERPINE1/CASP3/BAX/JAK2/PLCG2/KRAS/PIK3CB	0.95375469335381
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/537	86/9376	1.42115975921355	ATP1B3/ADCY9/CAMK2D/PRKACB/GNAQ/CAMK2G/ADCY7	0.967073430172085
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/537	102/9376	1.36940884361193	ATP1B3/ADCY9/GNAQ/CPB1/PRSS3/ADCY7/RAP1B/ATP2B1	0.924581165822073
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/537	72/9376	1.45499689633768	ISG15/MAP3K1/ADAR/IRF7/TRIM25/RNF125	0.955236801322502
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/537	103/9376	1.35611361212055	CASP3/PRKACB/GNAQ/ITGAM/IL1R2/GNA15/PIK3CB/ACTN4	0.895711749409406
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/537	134/9376	1.30298229522777	ADCY9/PRKACB/GNAQ/BRAF/ARHGEF1/PRKCH/ARHGEF12/ADCY7/PPP1R12B/ROCK2	0.870678624385582
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/537	73/9376	1.43506543200429	CDKN2A/BRAF/CDK6/BAX/KRAS/PIK3CB	0.919762527104153
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/537	119/9376	1.32050138491151	MMP9/CASP3/ITCH/CSF1/MLKL/RPS6KA5/TNFRSF1B/PIK3CB/MAP2K4	0.867240344754564
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/537	59/9376	1.47965786068238	ADCY9/PRKACB/ADCY7/PLIN1/PIK3CB	0.910942025451414
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/537	105/9376	1.33028287665159	ADCY9/PRKACB/ACTB/ITGB5/ITGA1/SNTB1/ADCY7/DAG1	0.838858349492566
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/537	75/9376	1.39679702048417	ATP1B3/ADCY9/PRKACB/GNAQ/ADCY7/TTF2	0.850365096290266
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/537	60/9376	1.45499689633768	PPP3CA/PLCG2/KRAS/PIK3CB/MAPKAPK3	0.871446105913741
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/537	201/9376	1.21611680887925	MMP9/PBX3/FUT8/FLI1/BAX/ITGAM/IL1R2/IGFBP3/TAF15/NSD2/ZEB1/RUNX1/KMT2A/NCOR1	0.763404564964753
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/537	18/9376	1.93999586178357	MANBA/FUCA1	0.983879445956308
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/537	32/9376	1.63687150837989	HIBCH/SUCLG2/BCKDHB	0.889470622469726
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/537	140/9376	1.24714019686087	SERPINE1/MEF2A/ADCY9/PRKACB/GNAQ/RRAS2/KLF2/ADCY7/PLIN1/KRAS	0.726167249454234
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/537	62/9376	1.40806151258485	ADCY9/PRKACB/ADCY7/KRAS/PIK3CB	0.79455611997775
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/537	93/9376	1.31419074507919	STAT4/MAML3/PPP3CA/NFATC3/NOTCH2/JAK2/ZAP70	0.750519363018814
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/537	78/9376	1.34307405815786	ZCCHC7/DHX36/TENT4B/PNPT1/XRN1/NUDT16	0.749914281165745
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	16/537	238/9376	1.17377900881023	RASA2/SOS1/PLD1/PRKACB/CSF1/RASA1/RRAS2/PLCG2/PAK2/RAP1B/EFNA5/RASGRP2/ZAP70/KRAS/TIAM1/PIK3CB	0.669316346179571
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/537	63/9376	1.38571132984541	CCNH/MNAT1/POLR2J/POLR2K/PCNA	0.757110175880722
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/537	79/9376	1.32607312071282	STX3/ATP6V0A2/ATP6V1A/ATP6V0C/STX2/AP2B1	0.717345443755552
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/537	49/9376	1.42530308212671	GALNT10/GALNT11/GXYLT1/B4GALT1	0.735693291239379
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/537	34/9376	1.54058494906342	POLR2J/POLR3GL/POLR2K	0.778313728741274
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/537	34/9376	1.54058494906342	CLOCK/CUL1/PER3	0.778313728741274
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	9/537	128/9376	1.22765363128492	ADCY9/PDE7A/ADK/AMPD3/ADCY7/NT5C/NME7/PAPSS1/NUDT16	0.639185435369553
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/537	226/9376	1.15884708557868	ATP1B3/VAV3/ADCY9/CAMK2D/PLD1/PRKACB/BRAF/CAMK2G/RRAS2/ADCY7/RAP1B/TIAM1/PIK3CB/ROCK2/ATP2B1	0.595791273327892
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/537	65/9376	1.34307405815786	LDLR/ADCY9/PRKACB/GNAQ/ADCY7	0.684096878620691
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/537	50/9376	1.39679702048417	KLRB1/KLRK1/PECAM1/ITGAL	0.693388944826643
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/537	130/9376	1.20876665234207	MMP9/SOS1/ADCY9/PRKACB/ADCY7/KRAS/GNA15/PIK3CB/MAP2K4	0.590781752648469
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/537	82/9376	1.27755825044284	DPYD/CDA/MGST2/NME7/CMPK1/GSTP1	0.622201347782026
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/537	21/9376	1.66285359581449	CHSY1/B3GAT3	0.749508533943249
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/537	52/9376	1.34307405815786	LDLR/ADCY9/PRKACB/ADCY7	0.611448147050986
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/537	69/9376	1.26521469246755	CAMK2D/PRKACB/PPP3CA/CAMK2G/MAOA	0.544989935536639
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/537	217/9376	1.12644921006788	BCL2/SOS1/ADCY9/PRKACB/RPS6KA3/CCND3/KPNA1/NOTCH2/JAK2/ADCY7/KPNB1/MGST2/KRAS/PIK3CB	0.464507972311045
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/537	86/9376	1.21813693646875	ACTB/ITGB5/ITGA1/SNTB1/LEF1/DAG1	0.500889343730261
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/537	38/9376	1.37841811231991	ATP1B3/KRAS/PIK3CB	0.576113421024413
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/537	103/9376	1.18659941060549	SERPINE1/GNAQ/CCL3/C3/GNA15/PIK3CB/MAP2K4	0.469342588498476
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/537	23/9376	1.51825763096106	IDI1/PDSS2	0.61334576427959
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/537	23/9376	1.51825763096106	MSH3/PCNA	0.61334576427959
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/537	155/9376	1.12644921006788	ACTB/ITGB5/HLA-C/ITGAM/ATP6V0A2/PIKFYVE/C3/ATP6V1A/ATP6V0C/CORO1A	0.391258848838384
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/537	89/9376	1.17707614085745	SOS1/ADCY9/PRKACB/GNAQ/ADCY7/KRAS	0.413702878975292
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/537	107/9376	1.14224055413425	CAMK2D/PRKACB/GNAQ/PPP3CA/SIK2/CAMK2G/PHKB	0.364728833282023
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/537	142/9376	1.10661735777795	TYROBP/PPP3CA/LCP2/CSF1/ACP5/CTSK/PLCG2/IRF9/PIK3CB	0.315535601085941
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/537	93/9376	1.12644921006788	ATP1B3/ADCY9/PRKACB/GNAQ/ADCY7/ATP2B1	0.30205402953692
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/537	43/9376	1.21813693646875	APOA1/PLPP3/PLPP1	0.353365396358749
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/537	44/9376	1.19045200609446	PARP4/HMGB1/PCNA	0.312101415866216
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/537	44/9376	1.19045200609446	ADCY9/PRKACB/ARHGDIB	0.312101415866216
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/537	45/9376	1.16399751707014	KLRC1/PRF1/HLA-C	0.271800748969784
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/537	166/9376	1.05180498530435	ATP1B3/MEF2A/ADCY9/GNAQ/PPP3CA/NFATC3/ADCY7/GTF2I/ROCK2/ATP2B1	0.165984294880638
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/537	254/9376	1.03110016275898	STIM1/ADCY9/CAMK2D/PRKACB/GNAQ/ORAI2/PPP3CA/CAMK2G/PHKB/NFATC3/PLCG2/ADCY7/STIM2/GNA15/ATP2B1	0.123852763206153
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/537	63/9376	1.10856906387633	WNT4/BAX/WNT6/LEF1	0.213109485478572
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/537	150/9376	1.04759776536313	BCL2/SOS1/BRAF/WNT4/BAX/WNT6/KRAS/LEF1/PIK3CB	0.144842723483653
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/537	133/9376	1.05022332367231	SOS1/BRAF/DEPP1/NLK/KLF2/KRAS/PIK3CB/SGK3	0.143779181872536
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/537	133/9376	1.05022332367231	CAMK2D/PRKACB/GNAQ/CLOCK/PPP3CA/CAMK2G/MAOA/PPP2R5C	0.143779181872536
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/537	116/9376	1.05361844217556	ADCY9/PLD1/PRKACB/GNAQ/PPP3CA/ADCY7/SLC38A1	0.143221727334589
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/537	12/9376	1.45499689633768	NCAM1	0.388722401257591
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/537	187/9376	1.02705663270895	BCL2/ANTXR2/IFI16/MFN1/GBP3/OAS1/OAS2/IRF9/IRF7/NEK7/OAS3	0.0921152717779409
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/537	100/9376	1.04759776536313	CCR1/CSF1/CCL3/TNFRSF10A/TNFRSF1B/CCL8	0.117944422403592
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/537	48/9376	1.09124767225326	HIBCH/BCKDHB/ACADSB	0.156213786114378
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/537	13/9376	1.34307405815786	XRCC4	0.305086688026481
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/537	31/9376	1.12644921006788	HIBCH/DPYD	0.173811508498361
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/537	31/9376	1.12644921006788	SEC11A/SEC11C	0.173811508498361
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	8/537	138/9376	1.01217175397404	SOS1/PRKACB/BRAF/PHKB/PTPN1/SOCS2/KRAS/PIK3CB	0.0355038086131877
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/537	49/9376	1.06897731159503	PRKACB/MAOA/RGS9	0.119317605540119
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	13/537	227/9376	0.999909761359814	SOS1/PLD1/BRAF/NFE2L2/PRKD3/PTPN1/MGST2/KRAS/PRKD2/PIK3CB/MAP2K4/COX5B/UQCR11	-0.000339226577835653
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/537	157/9376	1.00088958474184	SERPINE1/AREG/PATJ/ACTB/DLG1/CCND3/WNT4/WNT6/LEF1	0.00277055297178538
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/537	157/9376	1.00088958474184	ERN1/CASP3/ITCH/BAX/PIK3CB/ADIPOR2/EIF2AK3/COX5B/UQCR11	0.00277055297178538
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/537	105/9376	0.997712157488694	BCL2/PLCG2/TRIM25/ZAP70/MALT1/ERC1	-0.00581070327468929
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/537	69/9376	1.01217175397404	REN/PRKACB/GNAQ/PPP3CA	0.0250117493565711
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/537	144/9376	0.969997930891786	CASP3/LPIN1/TRA2A/LEF1/C3/LPIN2/ADIPOR2/MAP2K4	-0.0894243453192769
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/537	15/9376	1.16399751707014	TPK1	0.1566725795139
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	13/537	235/9376	0.965870280122033	DPF3/SOS1/ADCY9/PRKACB/RPS6KA3/ACTB/ARID1B/SMARCA2/ADCY7/PLIN1/KRAS/COX5B/UQCR11	-0.130599349734989
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/537	90/9376	0.969997930891786	ATP1B3/LDLR/ADCY9/PRKACB/ADCY7	-0.0704902963258017
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	6/537	109/9376	0.961098867305622	CTSK/CCL3/IRF9/IRF7/PIK3CB/MAP2K4	-0.100687864170749
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	20/537	362/9376	0.964638826301223	PRL/BCL2/SOS1/AREG/OSM/ITGB5/ITGA1/CDK6/CCND3/PIK3AP1/CSF1/PRLR/LPAR3/JAK2/PPP2R5C/EFNA5/KRAS/PIK3CB/PHLPP1/SGK3	-0.169119386326566
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/537	54/9376	0.969997930891786	ATR/FANCC/FANCL	-0.0544960157513303
NA	NA	hsa04081	Hormone signaling	12/537	219/9376	0.956710288002857	PRL/ADCY9/PRKACB/GNAQ/PRLR/JAK2/SLC40A1/ADCY7/GNA15/PIK3CB/ADIPOR2/SLC16A10	-0.159772253574503
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/537	110/9376	0.952361604875571	BCL2/SERPINE1/CAMK2D/CAMK2G/PLCG2/PIK3CB	-0.12387353490884
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/537	16/9376	1.09124767225326	MAOA	0.0900357684060651
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/537	36/9376	0.969997930891786	GALNT10/GALNT11	-0.0444529138088943
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/537	36/9376	0.969997930891786	PRIM2/PCNA	-0.0444529138088943
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/537	93/9376	0.938707675056567	BCL2/CASP3/CDK6/BAX/PIK3CB	-0.146411303944974
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/537	56/9376	0.93535514764565	CASP3/ITGAM/C3	-0.119588995860659
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/537	17/9376	1.02705663270895	PAPSS1	0.027520397173505
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/537	17/9376	1.02705663270895	DAG1	0.027520397173505
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/537	37/9376	0.943781770597413	GFPT1/GMDS	-0.0844498829147972
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/537	37/9376	0.943781770597413	APOA1/GNAQ	-0.0844498829147972
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/537	38/9376	0.918945408213271	PTPRC/ZAP70	-0.123399585389068
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/537	115/9376	0.910954578576633	CASP3/PRKACB/GNAQ/BRAF/MAOA/KRAS	-0.236811498422303
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/537	78/9376	0.895382705438571	CASP3/SERPING1/ITGAM/C3	-0.228679497569123
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/537	78/9376	0.895382705438571	ITGAM/JAK2/PTPN6/C3	-0.228679497569123
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/537	39/9376	0.895382705438571	PRF1/HLA-C	-0.161362763516859
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/537	59/9376	0.887794716409431	MGST2/SMS/GSTP1	-0.21309461739026
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/537	117/9376	0.895382705438571	DPF3/ACTB/ARID1B/SMARCA2/PHF6/MEAF6	-0.28066327446086
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/537	19/9376	0.918945408213271	IDS	-0.0871680484071983
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/537	19/9376	0.918945408213271	BCKDHB	-0.0871680484071983
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/537	60/9376	0.872998137802607	GNAQ/BRAF/KRAS	-0.243244029017669
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/537	99/9376	0.881816300810714	KRT23/ITGAM/CFH/C3/ITGAL	-0.291368509627039
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/537	99/9376	0.881816300810714	ACTB/ITGB5/ITGA1/SNTB1/DAG1	-0.291368509627039
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/537	100/9376	0.872998137802607	ITGA1/CSF1/CD37/ITGAM/IL1R2	-0.314703036303794
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/537	61/9376	0.858686692920597	ATP1B3/SLC40A1/ATP2B1	-0.272915223695098
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/537	41/9376	0.851705500295226	RAD51B/BABAM2	-0.234547616799408
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/537	233/9376	0.899225549667921	ATP1B3/FBN2/ACTB/ITGB5/ITGA1/NID2/AMPD3/SNTB1/FMNL1/FMNL2/FMNL3/DAG1	-0.38393283230843
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/537	20/9376	0.872998137802607	GMDS	-0.140136476707267
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/537	103/9376	0.847571007575347	PPP2R5C/PABPN1/CPSF6/UPF2/UPF3A	-0.383395733323385
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/537	103/9376	0.847571007575347	ATP1B3/COL14A1/CPB1/PRSS3/SLC16A10	-0.383395733323385
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/537	21/9376	0.831426797907245	DPYD	-0.190610799067039
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/537	238/9376	0.880334256607671	ISG15/MX1/EIF2AK2/RPL36AL/ADAR/OAS1/OAS2/PLCG2/IRF9/C3/OAS3/PIK3CB	-0.460897082326446
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/537	44/9376	0.793634670729643	PRF1/HLA-C	-0.338179223058594
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/537	22/9376	0.793634670729643	MAOA	-0.238847448617857
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/537	65/9376	0.805844434894714	GNAQ/KRAS/PIK3CB	-0.387150275274524
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/537	23/9376	0.759128815480528	B4GALT1	-0.285065403645021
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/537	23/9376	0.759128815480528	ATP1B3	-0.285065403645021
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/537	109/9376	0.800915722754685	PPP3CA/NFATC3/JAK2/ZAP70/RUNX1	-0.515290154230014
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/537	24/9376	0.727498448168839	B3GAT3	-0.329453075186899
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/537	89/9376	0.784717427238298	CD47/ITGB5/ITGA1/DAG1	-0.502964542334489
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/537	89/9376	0.784717427238298	ADCY9/PRKACB/ADCY7/SLC38A1	-0.502964542334489
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/537	47/9376	0.74297713855541	ME1/ME2	-0.435385890522828
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/537	47/9376	0.74297713855541	SOCS2/PIK3CB	-0.435385890522828
NA	NA	hsa03272	Virion - Hepatitis viruses	2/537	48/9376	0.727498448168839	LDLR/PDCD6IP	-0.466516000708923
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/537	48/9376	0.727498448168839	ATP1B3/PIK3CB	-0.466516000708923
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	13/537	268/9376	0.846938491898052	ERN1/CAMK2D/CASP3/PRKACB/NFE2L2/CAMK2G/BAX/MFN1/MAOA/UBE2J1/EIF2AK3/COX5B/UQCR11	-0.626603892221686
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/537	70/9376	0.74828411811652	JAK2/TNFRSF1B/ADIPOR2	-0.521013921737016
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/537	91/9376	0.767470890375918	ADCY9/PRKACB/PDE7A/ADCY7	-0.549386881430442
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/537	26/9376	0.671537029078929	APOA1	-0.413369566461226
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/537	50/9376	0.698398510242086	MAOA/SMS	-0.527038077267332
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/537	195/9376	0.805844434894714	ACTB/HDAC9/ITGAM/PLCG2/HMGB1/C3/ITGAL/PIK3CB/HDAC8	-0.675294743813614
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/537	73/9376	0.717532716002143	MAOA/MGST2/GSTP1	-0.597158045301922
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/537	27/9376	0.64666528726119	ELOVL6	-0.453165482454667
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/537	28/9376	0.623570098430434	ELOVL6	-0.49167145148718
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/537	28/9376	0.623570098430434	B4GALT1	-0.49167145148718
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/537	28/9376	0.623570098430434	MOCS2	-0.49167145148718
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/537	138/9376	0.759128815480528	ATP6V0A2/PPA2/ATP6V1A/ATP6V0C/COX5B/UQCR11	-0.702597542954987
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/537	76/9376	0.689209056159953	APOA1/ME1/PLIN1	-0.670509431882023
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/537	29/9376	0.602067681243177	RGS9	-0.528984935424351
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/537	54/9376	0.64666528726119	AHCYL2/SMS	-0.641800203894403
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/537	54/9376	0.64666528726119	PRF1/HLA-C	-0.641800203894403
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/537	30/9376	0.581998758535071	SUCLG2	-0.565192675092724
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/537	30/9376	0.581998758535071	PIGK	-0.565192675092724
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	15/537	323/9376	0.810834183717592	BCL2/MMP9/CDKN2A/SOS1/CASP3/CDK6/NOTCH2/PLCG2/RPS6KA5/CCNG1/EFNA5/KRAS/ZEB1/PIK3CB/MDM4	-0.852744395721597
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	9/537	205/9376	0.766534950265704	MMP9/CAMK2D/REN/CAMK2G/GFPT1/CTSD/PIK3CB/COX5B/UQCR11	-0.833031977178985
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/537	144/9376	0.727498448168839	ERN1/GNAQ/ATXN10/ATXN2/DAB1/PIK3CB	-0.812219743348192
NA	NA	hsa04519	Cadherin signaling	19/537	404/9376	0.821136862289581	VAV3/MYO1F/ACTB/CYFIP2/WNT4/KRT23/ARPC5L/RRAS2/ADAM10/WNT6/TAOK1/TMC6/MYO7A/KRAS/LEF1/ARPC1B/ACTN4/ROCK2/ACTR2	-0.905812082342952
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/537	57/9376	0.61263027214218	ACADSB/ELOVL6	-0.72301892412611
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/537	32/9376	0.545623836126629	B4GALT1	-0.634593075680155
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	17/537	368/9376	0.806574366448061	BCL2/ERN1/CASP3/ANXA11/ACTB/PPP3CA/BAX/RANBP2/PFN1/ATXN2/TNFRSF1B/NUP210/NUP58/EIF2AK3/NUP133/COX5B/UQCR11	-0.933028613739285
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/537	33/9376	0.529089780486429	BCKDHB	-0.667917965316405
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/537	35/9376	0.498856078744347	GMDS	-0.732101028678551
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/537	109/9376	0.640732578203748	RPS6KA3/GFPT1/PTPN1/PIK3CB	-0.929892444289278
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/537	298/9376	0.761676227613013	PRL/IL1RL1/TNFRSF18/TNFRSF4/OSM/CCR1/CSF1/PRLR/IL1R2/CCL3/TNFRSF10A/TNFRSF1B/CCL8	-1.03050860256714
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/537	87/9376	0.602067681243177	ATP1B3/COX5B/UQCR11	-0.919084774188348
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/537	37/9376	0.471890885298707	GFPT1	-0.79331479089075
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/537	37/9376	0.471890885298707	MAOA	-0.79331479089075
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/537	112/9376	0.623570098430434	BCL2/LDLR/CASP3/JAK2	-0.987791003428432
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/537	38/9376	0.459472704106635	GFPT1	-0.822912591802548
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/537	38/9376	0.459472704106635	NT5C	-0.822912591802548
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/537	39/9376	0.447691352719286	AHCYL2	-0.851886392332042
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/537	116/9376	0.602067681243177	HIBCH/SUCLG2/ME1/ME2	-1.06292819675742
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/537	41/9376	0.425852750147613	MAOA	-0.90809078834956
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/537	94/9376	0.557232853916558	MMP9/CASP3/USP25	-1.06338308309144
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/537	70/9376	0.498856078744347	MGST2/GSTP1	-1.0372923544369
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/537	42/9376	0.415713398953622	MAOA	-0.935379587364514
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/537	42/9376	0.415713398953622	SLC40A1	-0.935379587364514
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/537	71/9376	0.491829936790201	KRAS/PIK3CB	-1.05937879702974
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/537	43/9376	0.406045645489585	ACADSB	-0.962161288675848
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/537	144/9376	0.606248706807366	WNT4/JAK2/WNT6/KRAS/PIK3CB	-1.17361744236265
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/537	122/9376	0.572457795280398	PPP2R5C/PIK3CB/CAB39L/ADIPOR2	-1.17156226315737
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	21/537	480/9376	0.763873370577281	BCL2/ERN1/CAMK2D/CASP3/GNAQ/BRAF/PPP3CA/CSF1/CAMK2G/WNT4/BAX/MFN1/ATXN2/WNT6/TNFRSF1B/KRAS/HIP1/UBE2J1/EIF2AK3/COX5B/UQCR11	-1.30899929761114
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/537	191/9376	0.639893922996675	SOS1/PRKACB/BRAF/HDAC9/MAOA/KRAS/HDAC8	-1.23930661498046
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/537	45/9376	0.387999172356714	ABCB10	-1.01429757166645
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/537	46/9376	0.379564407740264	PSME2	-1.03969513525271
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/537	154/9376	0.56688190766403	TPK1/MOCS2/NME7/CMPK1/CMPK2	-1.33575048690127
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/537	79/9376	0.44202437357094	MGST2/GSTP1	-1.22751998837112
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/537	110/9376	0.476180802437786	CUL1/LEMD3/NCOR1	-1.36208063864582
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	15/537	388/9376	0.674998560156655	ERN1/EIF2AK2/CASP3/GNAQ/BRAF/PPP3CA/CSF1/WNT4/ADAM10/WNT6/KRAS/PIK3CB/EIF2AK3/COX5B/UQCR11	-1.61153903689113
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/537	149/9376	0.468723832377239	ADCY9/PRKACB/GNAQ/ADCY7	-1.6112184356003
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	9/537	275/9376	0.571416962925343	CASP3/PRKACB/PPP3CA/BAX/NCAM1/PIK3CB/EIF2AK3/COX5B/UQCR11	-1.77798454631285
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/537	66/9376	0.264544890243214	STAT4	-1.47783011078306
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	10/537	308/9376	0.56688190766403	ERN1/CASP3/GNAQ/POLR2J/BAX/POLR2K/HIP1/COX5B/AP2B1/UQCR11	-1.90500948433637
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/537	194/9376	0.449999040104437	MYO1F/ACTB/STARD9/KIFAP3/MYO7A	-1.9079495297779
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/537	83/9376	0.210360997060869	PEX14	-1.78098754852422
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/537	86/9376	0.203022822744792	PRKACB	-1.83003108847886
NA	NA	hsa04082	Neuroactive ligand signaling	4/537	199/9376	0.350954025247279	ADCY9/PRKACB/GNAQ/ADCY7	-2.28098719536682
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/537	143/9376	0.244195283301429	C3/ACTN4	-2.24479875549415
NA	NA	hsa04382	Cornified envelope formation	3/537	217/9376	0.241381973585974	KRT23/PPP2R5C/S100A11	-2.78676411674711
Genetic Information Processing	Translation	hsa03010	Ribosome	2/537	222/9376	0.157296961766236	RPL36AL/MRPL1	-3.13196432825794
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/537	183/9376	0.095409632546733	XRN1	-3.04593118785876
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/537	370/9376	0.283134531179224	PRL/PRSS3/PRLR/LPAR3/PGRMC2/C3	-3.46771794505989
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/537	243/9376	0.143703397169153	TRA2A/PRPF38B	-3.33343386457844
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/537	449/9376	0.155545325220954	NCALD/CAMK2D/PRKACB/CAMK2G	-4.51978692468835