category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	65/1494	138/9376	2.95597850338552	ATP6V0E1/NDUFA4/NDUFC2/ATP6V0B/MT-CO2/ATP5MG/ATP6V0C/UQCR11/NDUFA13/COX7B/UQCR10/UQCRQ/ATP6V1G1/COX7A2/COX17/NDUFB3/ATP5F1E/COX8A/ATP6V1E1/NDUFS8/NDUFA7/MT-ND4/NDUFA3/SDHC/NDUFA5/COX7A2L/NDUFC1/ATP6AP1/PPA1/ATP6V1H/ATP6V1C1/ATP5MF/COX6A1/NDUFS7/ATP6V1F/NDUFB11/NDUFB2/NDUFS2/COX6B1/NDUFS6/MT-ND2/ATP6V0E2/NDUFAB1/NDUFA1/NDUFA8/NDUFA6/ATP5PF/COX7A1/COX5B/NDUFB4/NDUFV2/ATP6V1A/NDUFB5/NDUFS4/COX6C/SDHD/PPA2/ATP5PD/ATP6V1B2/NDUFA2/UQCRC1/ATP6V1G2/COX5A/MT-ND3/ATP6V0D2	10.0776057329328
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	92/1494	250/9376	2.30948326639893	CTSD/NPC2/ATP6V0E1/CTSB/GPR155/CD68/ASAH1/ATP6V0B/AGA/SLC29A1/ATP6V0C/CTSL/CTSZ/DEPTOR/ATP6V1G1/BORCS7/GM2A/HEXB/ATP6V1E1/VPS41/GALNS/CLTB/CTSA/TPP1/GNPTG/CTSW/OSBPL3/CTSO/SNAPIN/SNAP29/CTBS/ATP6AP1/LAPTM4A/VAMP8/ATP6V1H/ACP2/ATP6V1C1/CLN5/BORCS8/CTSH/OSTM1/ARL8B/ATP6V1F/GAA/FIG4/LAMP1/CD164/LAMTOR5/ARSB/LAMTOR2/PSAP/GNPTAB/HEXA/SGSH/DMXL1/ATP6V0E2/TMEM175/IDS/PPT1/GNS/VPS16/NAGPA/NEU1/FUCA2/SUMF1/AP2S1/CLN3/FUCA1/AP5M1/BLOC1S2/ATP6V1A/SMPD1/VPS29/AP5B1/CD63/SLC15A4/NAGA/ACP5/CTSV/SLC17A5/KXD1/BORCS5/LAMTOR3/ATP6V1B2/BLOC1S1/SORT1/ATP6V1G2/VPS33A/CTNS/RRAGD/PLA2G15/ATP6V0D2	9.13634407671162
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	78/1494	235/9376	2.0830214474921	NDUFA4/NDUFC2/RHEB/PLIN1/MT-CO2/CNR1/ATP5MG/UQCR11/NDUFA13/COX7B/UQCR10/SMARCB1/UQCRQ/COX7A2/NDUFAF3/COX17/NDUFB3/MAPK14/ATP5F1E/COX8A/NDUFS8/RPS6KA2/NDUFA7/MT-ND4/PNPLA2/COX20/MAP3K5/NDUFA3/SDHC/NDUFA5/COX7A2L/NDUFC1/COX16/ATP5MF/CREB3L1/COX6A1/NDUFS7/NDUFB11/NDUFB2/NDUFS2/COX6B1/NDUFS6/MT-ND2/NDUFAB1/COA1/NDUFA1/NDUFA8/COX14/NDUFA6/COA3/PRKACB/ATP5PF/COX7A1/COX5B/BMP8A/ACSL3/NDUFAF8/NDUFB4/NDUFV2/CPT1C/NDUFB5/PRKAG1/NDUFS4/COX6C/SDHD/ADCY7/NPR1/ATP5PD/NDUFA2/PRKAB2/UQCRC1/COA5/COX5A/RPS6KB2/SLC25A20/RPS6KA1/MT-ND3/PRKAA2	7.32009732928055
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	66/1494	205/9376	2.02049172298952	TGFBR1/CTSD/NDUFA4/REN/NDUFC2/MMP9/MT-CO2/CYBA/UQCR11/PPP1CB/NDUFA13/COX7B/UQCR10/UQCRQ/COX7A2/SLC25A4/TBC1D4/NDUFB3/MAPK14/ATP5F1E/COX8A/NDUFS8/NDUFA7/MT-ND4/NDUFA3/RAC2/SDHC/NDUFA5/COX7A2L/NDUFC1/COX6A1/NDUFS7/NDUFB11/NDUFB2/NDUFS2/COX6B1/NDUFS6/MT-ND2/NDUFAB1/PPIF/NDUFA1/PIK3CB/NDUFA8/NDUFA6/ATP5PF/COX7A1/COX5B/G6PD/PARP1/NDUFB4/NDUFV2/NDUFB5/NDUFS4/COX6C/PIK3CD/SDHD/ATP5PD/NDUFA2/AGT/UQCRC1/COX5A/MT-ND3/NCF4/PDK4/PLCB2/NOS3	6.43162614633623
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	77/1494	268/9376	1.80311294930968	CALM2/NDUFA4/MAOA/NDUFC2/MAOB/MT-CO2/UQCR11/NDUFA13/COX7B/UQCR10/UQCRQ/COX7A2/SLC25A4/NDUFB3/ATP5F1E/COX8A/NDUFS8/NDUFA7/TUBA3E/MT-ND4/MAP3K5/NDUFA3/PSMD3/SDHC/NDUFA5/SLC39A2/COX7A2L/NDUFC1/COX6A1/NDUFS7/SLC39A10/SLC39A11/NDUFB11/ATF6/NDUFB2/NDUFS2/COX6B1/NDUFS6/TUBA4A/MT-ND2/SLC39A4/NDUFAB1/PPIF/PSMA2/TH/NDUFA1/NDUFA8/SLC39A6/NDUFA6/PARK7/PRKACB/ATP5PF/COX7A1/COX5B/NDUFB4/NDUFV2/SLC39A7/PSMA1/KIF5C/NDUFB5/PSMD6/NDUFS4/CALM3/TUBA3D/COX6C/GPR37/SDHD/ATP5PD/UBE2L6/NDUFA2/UQCRC1/PSMB3/PINK1/COX5A/ADRM1/UCHL1/MT-ND3	5.80731302838506
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	101/1494	388/9376	1.63364109358396	WNT6/WNT4/CALM2/NDUFA4/NDUFC2/MT-CO2/WNT5A/UQCR11/DKK1/NDUFA13/MME/COX7B/UQCR10/UQCRQ/COX7A2/SLC25A4/NDUFB3/ATP5F1E/COX8A/NDUFS8/NDUFA7/TUBA3E/MT-ND4/WNT3/NCSTN/APOE/APH1B/MAP3K5/NDUFA3/PSMD3/SDHC/NDUFA5/SLC39A2/COX7A2L/NDUFC1/PSENEN/CSF1/COX6A1/NDUFS7/SLC39A10/SLC39A11/NDUFB11/ATF6/NDUFB2/RTN3/CSNK2B/NDUFS2/COX6B1/NDUFS6/TUBA4A/MT-ND2/SLC39A4/NDUFAB1/PPIF/PSMA2/NDUFA1/PIK3CB/PSEN2/NDUFA8/SLC39A6/WNT10B/NDUFA6/ATP5PF/COX7A1/COX5B/IL1B/NDUFB4/NDUFV2/SLC39A7/PSMA1/PPP3CB/WNT9A/WNT16/KIF5C/NDUFB5/PSMD6/NDUFS4/EIF2AK2/CALM3/LPL/TUBA3D/COX6C/PIK3CD/SDHD/BACE2/ATP5PD/ATG2B/NDUFA2/UQCRC1/NAE1/WNT9B/WNT1/PSMB3/COX5A/ADRM1/GRIN2D/CHUK/MT-ND3/PLCB2/WNT3A/NOX4	5.54971124934638
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	36/1494	95/9376	2.37818642993025	ATP6V0E1/ATP6V0B/HLA-DMA/CCL3/ATP6V0C/CTSL/ATP6V1G1/ATP6V1E1/ATP6AP1/ATP6V1H/ATP6V1C1/HLA-DPA1/CCL2/CSF1/HLA-DPB1/ATP6V1F/HLA-DQA1/ATP6V0E2/IL1B/CCL5/IL18/ANGPT1/ATP6V1A/ACP5/CD86/TLR2/ATP6V1B2/HLA-DMB/ATP6V1G2/TEK/IL11/LTB/TNFRSF11A/TNFSF13/ATP6V0D2/IFNG	5.87780409869291
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	51/1494	157/9376	2.03862584094339	NDUFA4/NDUFC2/MT-CO2/UQCR11/NDUFA13/COX7B/UQCR10/UQCRQ/COX7A2/NDUFB3/MAPK14/COX8A/NDUFS8/ADIPOR1/NDUFA7/MAP3K5/NDUFA3/SDHC/NDUFA5/COX7A2L/NDUFC1/COX6A1/NDUFS7/NDUFB11/NDUFB2/LEPR/NDUFS2/COX6B1/NDUFS6/NDUFAB1/NDUFA1/PIK3CB/NDUFA8/NDUFA6/COX7A1/COX5B/IL1B/NDUFB4/NDUFV2/NDUFB5/PRKAG1/NDUFS4/COX6C/PIK3CD/SDHD/NDUFA2/PRKAB2/UQCRC1/COX5A/RXRA/PRKAA2	5.71359909426646
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	82/1494	308/9376	1.67082181540013	NDUFA4/NDUFC2/MT-CO2/SLC1A2/POLR2K/UQCR11/POLR2L/NDUFA13/COX7B/UQCR10/DCTN6/UQCRQ/COX7A2/SLC25A4/NDUFB3/ATP5F1E/COX8A/NDUFS8/POLR2I/NDUFA7/TUBA3E/MT-ND4/CLTB/GPX3/MAP3K5/DNAI1/NDUFA3/PSMD3/SDHC/NDUFA5/COX7A2L/NDUFC1/POLR2J/CREB3L1/COX6A1/NDUFS7/GPX8/NDUFB11/NDUFB2/POLR2A/NDUFS2/COX6B1/TBPL1/NDUFS6/TUBA4A/MT-ND2/NDUFAB1/PPIF/PSMA2/NDUFA1/DNALI1/NDUFA8/NDUFA6/DNAH14/ATP5PF/COX7A1/COX5B/AP2S1/NDUFB4/NDUFV2/PSMA1/ACTR10/KIF5C/NDUFB5/PSMD6/NDUFS4/TUBA3D/COX6C/SDHD/DNAH5/ATP5PD/ATG2B/ACTR1A/NDUFA2/SLC1A3/UQCRC1/PSMB3/COX5A/ADRM1/MT-ND3/DNAH11/PLCB2	5.21158111642624
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	75/1494	275/9376	1.71157356699525	NDUFA4/NDUFC2/MT-CO2/CYBA/UQCR11/NDUFA13/COX7B/UQCR10/UQCRQ/NCAM1/COX7A2/CAV2/SLC25A4/NDUFB3/MAPK14/ATP5F1E/COX8A/NDUFS8/C1QB/NDUFA7/TUBA3E/MT-ND4/NDUFA3/PSMD3/RAC2/SDHC/NDUFA5/COX7A2L/NDUFC1/CREB3L1/COX6A1/NDUFS7/NDUFB11/NDUFB2/CSNK2B/NDUFS2/COX6B1/NDUFS6/TUBA4A/MT-ND2/NDUFAB1/PPIF/PSMA2/NDUFA1/PIK3CB/NDUFA8/NDUFA6/PRKACB/ATP5PF/COX7A1/COX5B/IL1B/NDUFB4/NDUFV2/CCL5/PSMA1/PPP3CB/KIF5C/NDUFB5/PSMD6/NDUFS4/TUBA3D/COX6C/PIK3CD/SDHD/ATF6B/ATP5PD/NDUFA2/UQCRC1/PSMB3/COX5A/ADRM1/GRIN2D/MT-ND3/NCF4	5.21415957517035
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	53/1494	174/9376	1.91158503746788	ERLEC1/SKP1/SIL1/RPN2/DERL1/BCAP31/SSR4/SEC61G/TUSC3/RBX1/ERP29/SSR1/UBE2D1/CRYAB/MAN1A1/AMFR/LMAN2/MAP3K5/SAR1A/SAR1B/RAD23A/WFS1/SEL1L/RRBP1/KRTCAP2/RPN1/ATF6/UBXN8/MAGT1/HSP90B1/DAD1/DERL2/MAN1B1/DNAJC10/PDIA6/BCAP29/LMAN1/DNAJC5/SVIP/FBXO6/MBTPS2/SELENOS/UBXN2A/TRAM1/SEC62/ATF6B/TMEM258/UBE2D4/STUB1/RNF5/GANAB/DERL3/FBXO2	5.28412909893488
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	24/1494	56/9376	2.68961560527826	RPN2/SRD5A3/TUSC3/ST6GAL2/MAN1A1/MGAT4B/B4GALT3/MGAT1/ALG14/ALG8/KRTCAP2/RPN1/ALG5/MAGT1/DAD1/MAN1B1/DPM2/ST6GAL1/TMEM258/GANAB/ALG6/ALG3/MAN2A2/DOLK	5.5209865739366
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	15/1494	30/9376	3.13788487282463	PIGP/GPLD1/PIGX/PIGT/PIGC/PIGK/GPAA1/PIGF/DPM2/PIGU/PIGB/PIGH/PIGO/PIGV/B3GALT4	5.10592904165541
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	61/1494	227/9376	1.68644032812601	NDUFA4/NDUFC2/MT-CO2/CYBA/UQCR11/MGST1/NDUFA13/COX7B/UQCR10/UQCRQ/COX7A2/SLC25A4/NDUFB3/MAPK14/ATP5F1E/COX8A/NDUFS8/NDUFA7/MGST2/MT-ND4/PTPRJ/MAP3K5/NDUFA3/SDHC/NDUFA5/COX7A2L/NDUFC1/COX6A1/NDUFS7/NDUFB11/GSTA1/NDUFB2/NDUFS2/COX6B1/NDUFS6/MT-ND2/NDUFAB1/PPIF/NDUFA1/PIK3CB/NDUFA8/NDUFA6/GSTT2B/ATP5PF/COX7A1/COX5B/NDUFB4/NDUFV2/NDUFB5/NDUFS4/COX6C/PIK3CD/SDHD/ATP5PD/NDUFA2/UQCRC1/COX5A/CHUK/MT-ND3/SLC26A6/NOX4	4.55797172466558
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	87/1494	368/9376	1.48367382573773	NDUFA4/NDUFC2/MT-CO2/SLC1A2/ANG/DERL1/UQCR11/NDUFA13/COX7B/UQCR10/DCTN6/UQCRQ/COX7A2/CHCHD10/NDUFB3/MAPK14/ATP5F1E/COX8A/NDUFS8/NDUFA7/TUBA3E/MT-ND4/GPX3/MAP3K5/DNAI1/NDUFA3/NRG2/PSMD3/SDHC/NDUFA5/COX7A2L/NDUFC1/ANXA11/COX6A1/NDUFS7/GPX8/FIG4/RANBP2/NDUFB11/ATF6/NDUFB2/RAB1A/NDUFS2/COX6B1/NDUFS6/TUBA4A/MT-ND2/NDUFAB1/PSMA2/NDUFA1/DNALI1/NDUFA8/NDUFA6/DNAH14/ATP5PF/COX7A1/COX5B/NDUFB4/NDUFV2/PSMA1/PFN2/PPP3CB/ACTR10/KIF5C/NDUFB5/PSMD6/NDUFS4/TUBA3D/COX6C/SDHD/DNAH5/ATP5PD/ATG2B/ACTR1A/NDUFA2/NUP210/UQCRC1/PSMB3/PINK1/COX5A/PFN4/ADRM1/MAP1LC3C/GRIN2D/NXT2/MT-ND3/DNAH11	4.12102290340217
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	43/1494	154/9376	1.75232531859038	DHRS3/VKORC1/MOCS2/AK1/CMPK1/ALAD/VKORC1L1/PTS/GGCX/QPRT/UGDH/HSD17B6/AK6/MMAB/AK3/AK2/FPGS/MTHFD2L/AK9/COASY/RFK/KYNU/DHFR/PPCS/ALAS1/MAT2B/NME1/PPOX/ALDH3A2/BCAT2/GMPPB/ALDH1B1/AK5/KMO/PHOSPHO2/SPR/COQ6/CMPK2/OXSM/SHMT1/LIPT2/MOCS1/UGT2B7	4.09822879905804
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	13/1494	28/9376	2.91375023905144	TECR/ELOVL1/HACD1/ACOT7/PPT1/HACD4/HSD17B12/HACD3/ACOT2/HACD2/ELOVL4/ACOT4/ELOVL3	4.41517216845777
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	19/1494	51/9376	2.3380318660262	ATP6V0E1/ATP6V0B/ATP6V0C/ATP6V1G1/SEC61G/ATP6V1E1/ATP6AP1/ATP6V1H/ATP6V1C1/ATP6V1F/KDELR3/ATP6V0E2/PRKACB/ATP6V1A/TJP1/KDELR1/ATP6V1B2/ATP6V1G2/ATP6V0D2	4.17128483006804
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	17/1494	44/9376	2.42472921990994	RPN2/TUSC3/HEXB/MAN1A1/MGAT4B/B4GALT3/MGAT1/ALG14/KRTCAP2/RPN1/HEXA/MAGT1/DAD1/MAN1B1/TMEM258/ALG3/MAN2A2	4.12395603084935
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	42/1494	155/9376	1.70053115688561	ATP6V0E1/ATP6V0B/HLA-DMA/CYBA/ATP6V0C/CTSL/ATP6V1G1/SEC61G/HLA-E/SCARB1/ATP6V1E1/TUBA3E/CORO1A/ATP6AP1/ATP6V1H/ATP6V1C1/HLA-DPA1/SEC22B/HLA-DPB1/ATP6V1F/COLEC11/ITGB5/HLA-DQA1/LAMP1/STX7/TUBA4A/ATP6V0E2/MRC2/HLA-A/C3/OLR1/PLA2R1/ATP6V1A/DYNC1LI1/TUBA3D/TLR2/ATP6V1B2/HLA-DMB/ATP6V1G2/NCF4/SFTPD/ATP6V0D2	3.82866189108415
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	12/1494	27/9376	2.78923099806634	TECR/ELOVL1/HACD1/ACOT7/HACD4/HSD17B12/HACD3/ACOT2/HACD2/ELOVL4/ACOT4/ELOVL3	4.05329709547869
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	12/1494	28/9376	2.68961560527826	ATP6V0E1/ATP6V0C/ATP6V1G1/ATP6V1E1/ATP6V1C1/ATP6V1F/ATP6V0E2/ATP6V1A/ATP6V1B2/ATP6V1G2/ATP6V0D2/CA2	3.89807595766208
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	18/1494	52/9376	2.17238183503244	APOA1/NPC2/APOC3/APOC1/LRPAP1/TSPO/SCARB1/STARD3NL/APOE/SOAT1/VAPA/ANGPTL4/SOAT2/NCEH1/APOC2/LPL/CYP27A1/SORT1	3.69073056852009
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	102/1494	480/9376	1.33360107095047	WNT6/WNT4/CALM2/NDUFA4/NDUFC2/MT-CO2/WNT5A/DERL1/UQCR11/DKK1/NDUFA13/COX7B/UQCR10/DCTN6/UQCRQ/COX7A2/SLC25A4/NDUFB3/MAPK14/ATP5F1E/COX8A/NDUFS8/NDUFA7/TUBA3E/MT-ND4/WNT3/GPX3/MAP3K5/DNAI1/NDUFA3/PSMD3/SDHC/NDUFA5/COX7A2L/NDUFC1/CSF1/COX6A1/NDUFS7/GPX8/FIG4/NDUFB11/ATF6/NDUFB2/RAB1A/CSNK2B/NDUFS2/COX6B1/NDUFS6/TUBA4A/MT-ND2/NDUFAB1/PPIF/PSMA2/NDUFA1/PSEN2/DNALI1/NDUFA8/WNT10B/NDUFA6/PARK7/DNAH14/ATP5PF/COX7A1/COX5B/IL1B/NDUFB4/NDUFV2/PSMA1/PPP3CB/ACTR10/WNT9A/WNT16/KIF5C/NDUFB5/PSMD6/NDUFS4/CALM3/TUBA3D/COX6C/GPR37/SDHD/DNAH5/ATP5PD/UBE2L6/ATG2B/ACTR1A/NDUFA2/UQCRC1/WNT9B/WNT1/PSMB3/PINK1/COX5A/ADRM1/MAP1LC3C/GRIN2D/UCHL1/MT-ND3/DNAH11/PLCB2/WNT3A/NOX4	3.26658068216079
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	40/1494	158/9376	1.58880246725298	WNT6/WNT4/RHEB/SGK1/WNT5A/DEPTOR/ATP6V1G1/ATP6V1E1/RPS6KA2/WNT3/CAB39L/ATP6V1H/ATP6V1C1/ATP6V1F/EIF4E/LAMTOR5/LAMTOR2/RHOA/PIK3CB/WNT10B/ATP6V1A/WNT9A/WNT16/SLC3A2/LPIN2/PRR5/PIK3CD/LAMTOR3/ATP6V1B2/STRADB/ATP6V1G2/WNT9B/WNT1/RPS6KB2/RPS6KA1/CHUK/PRR5L/RRAGD/WNT3A/PRKAA2	3.24954484224062
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	28/1494	100/9376	1.75721552878179	CCL8/CCL3/CCL23/CCL4/XCL2/IL2RB/CXCL14/XCL1/CCL2/CSF1/IL18R1/CXCR4/IL2RA/CCL14/LTBR/CCL5/IL18/ACKR4/IL6ST/CCR10/IL10RB/IL34/CCL21/CXCR3/TNFSF14/CCL13/CCL28/ACKR3	3.31422404224766
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	31/1494	116/9376	1.67714536306144	THY1/MMP9/CLDN20/CYBA/MYL12A/RAP1B/CLDN4/MYL9/MAPK14/EZR/RAP1A/RAC2/ROCK2/ITK/RHOH/VAV3/AFDN/CLDN23/CXCR4/RHOA/PIK3CB/CLDN10/CLDN3/PIK3CD/CLDN5/ITGA4/CDH5/NCF4/CLDN7/CLDN12/OCLN	3.19483278018564
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/1494	20/9376	2.82409638554217	TM7SF2/SOAT1/SC5D/SOAT2/DHCR7/FDFT1/HSD17B7/EBP/DHCR24	3.55517018997474
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	11/1494	28/9376	2.46548097150507	PCBD1/MOCS2/AKR1B1/PTS/FPGS/TH/PCBD2/DHFR/QDPR/SPR/MOCS1	3.38097974686639
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	37/1494	149/9376	1.55841262140284	NDUFA4/NDUFC2/CNR1/NDUFA13/NDUFB3/MAPK14/NDUFS8/NDUFA7/MT-ND4/NDUFA3/NDUFA5/NDUFC1/NDUFS7/DAGLB/NDUFB11/NDUFB2/NDUFS2/NDUFS6/MT-ND2/NDUFAB1/NDUFA1/GNB5/NDUFA8/NDUFA6/PRKACB/GNGT1/NDUFB4/NDUFV2/NDUFB5/NDUFS4/ADCY7/GABRB3/NDUFA2/DAGLA/MT-ND3/GNGT2/PLCB2	2.99130585715153
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	12/1494	33/9376	2.282098089327	VAMP2/SNAP29/VAMP8/SEC22B/SNAP23/STX7/VAMP4/BET1L/GOSR2/STX11/YKT6/BNIP1	3.21201651919004
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	39/1494	160/9376	1.52971887550201	NECTIN2/HLA-DMA/CLDN20/NFASC/CLDN4/PTPRC/PTPRD/NCAM1/HLA-E/SDC2/PVR/SELPLG/SDC1/HLA-DPA1/CLDN23/HLA-DPB1/ALCAM/HLA-DQA1/ITGA6/CD58/ICAM2/HLA-A/CLDN10/CLDN3/CD2/CDH2/CD226/CD86/HLA-DMB/CLDN5/NLGN2/ITGA4/CDH5/CD22/CLDN7/SELE/CLDN12/NRCAM/OCLN	2.94223209358047
NA	NA	hsa03272	Virion - Hepatitis viruses	15/1494	48/9376	1.96117804551539	CD81/CLDN20/CLDN4/SCARB1/CLDN23/LAMP1/TSG101/CLDN10/CLDN3/CD63/CD9/CLDN5/CLDN7/CLDN12/OCLN	2.90651731204669
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	11/1494	31/9376	2.22688603877877	SEC11C/SPCS3/SRP14/SRP19/SEC61G/TMEM208/SPCS1/GET1/OXA1L/SEC62/SRP9	2.97877801747853
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	34/1494	142/9376	1.5026490940287	CALM2/MMP9/IL1R2/CYBA/CTSL/MGST1/CAV2/KLF2/MAPK14/SDC2/MGST2/MAPK7/MAP3K5/RAC2/SDC1/CCL2/GSTA1/KDR/HSP90B1/RHOA/MEF2A/PIK3CB/GSTT2B/IL1B/CALM3/THBD/PIK3CD/CDH5/CHUK/SELE/IFNG/PDGFB/PRKAA2/NOS3	2.62758553798407
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/1494	45/9376	1.95246169864644	HLA-DMA/KLRC1/GZMB/HLA-E/PRF1/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-A/IL1B/CD86/HLA-DMB/KIR2DL1/IFNG	2.78825445166566
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	15/1494	50/9376	1.88273092369478	MAOA/ARG1/MAOB/SAT1/SMOX/PYCR2/ODC1/GOT2/ALDH3A2/OAT/ALDH1B1/GOT1/CKMT2/GAMT/NOS3	2.72463517637466
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	21/1494	79/9376	1.66824259061563	ATP6V0E1/ATP6V0B/SLC1A1/SLC1A2/ATP6V0C/VAMP2/ATP6V1G1/ATP6V1E1/CLTB/ATP6V1H/ATP6V1C1/NAPA/ATP6V1F/ATP6V0E2/STXBP1/AP2S1/ATP6V1A/ATP6V1B2/SLC1A3/ATP6V1G2/ATP6V0D2	2.59668341369253
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	40/1494	180/9376	1.39461549903317	B2M/NECTIN2/RHEB/HLA-DMA/BST2/PPP1CB/HLA-E/CD74/HLA-DPA1/CCL2/IFIH1/HLA-DPB1/IRF7/IFNAR2/STAT1/HLA-DQA1/IRF9/PIK3CB/HLA-A/C3/IL1B/CCL5/TAPBP/EIF2AK2/IFNGR1/OAS3/IFNAR1/IRAK4/PIK3CD/JAK2/TLR2/RNASEL/HLA-DMB/BIRC3/CARD9/OAS2/CHUK/TAPBPL/TNFSF14/IFNG	2.32730676359047
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	38/1494	170/9376	1.40281911961572	CLDN20/MYL12A/MYH10/CLDN4/ARPC1B/SYNPO/MYL9/TUBA3E/EZR/MPDZ/MAP3K5/RAP1A/ROCK2/PPP2R1B/AFDN/CLDN23/TUBA4A/RHOA/CGN/HCLS1/PRKACB/CD1D/CLDN10/PARD6B/CLDN3/PRKAG1/TJP1/ARPC5/TUBA3D/CLDN5/PRKAB2/ACTR3B/CLDN7/CLDN12/OCLN/WAS/PRKAA2/PPP2R2B	2.30750033652012
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	22/1494	88/9376	1.56894243641232	CFH/CD59/SERPING1/CLU/TFPI/VTN/PLAUR/F3/F2R/SERPINE1/C1QB/F12/CD46/MASP1/SERPINB2/C3/SERPINA5/PROS1/THBD/F10/FGG/KNG1	2.33448604743834
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/1494	31/9376	2.02444185343525	PGD/H6PD/RBKS/ALDOC/DERA/PGM2/G6PD/GLYCTK/PFKM/FBP1	2.48726024809557
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/1494	31/9376	2.02444185343525	GLUL/MCEE/MDH2/ACSS1/AGXT2/ACO2/PCCB/GLYCTK/MDH1/SHMT1	2.48726024809557
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	61/1494	298/9376	1.28463743115639	IL1RL1/TGFBR1/PRL/TNFRSF21/CCL8/PRLR/IL1R2/CCL3/CCL23/CCL4/XCL2/INHA/IL2RB/CXCL14/XCL1/TNFRSF12A/TNFRSF18/TNFRSF8/CCL2/CSF1/CSF3R/IFNAR2/IL18R1/CXCR4/LEPR/CSF2RB/IL2RA/CCL14/ACVR1C/LTBR/BMP8A/IL1B/CCL5/IL18/ACKR4/IFNGR1/TNFRSF4/IFNAR1/IL6ST/IL11RA/GDF15/CCR10/OSM/CNTFR/IL10RB/GHR/IL34/CCL21/CXCR3/IL21R/TNFSF14/IL11/CCL13/CCL28/LTB/TNFRSF11A/TNFSF13/IFNG/IL13RA2/ACKR3/CTF1	2.17394111244682
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	43/1494	200/9376	1.34929049531459	TMBIM6/TMED10/WIPF1/CLDN20/MYH10/CLDN4/ARPC1B/F2R/NCK1/ABI1/MAPK14/TUBA3E/EZR/MYO1B/ROCK2/MYO1D/LPAR1/CLDN23/MYO5A/RAB1A/TUBA4A/RHOA/HCLS1/CLDN10/WASF2/IL1B/IL18/CLDN3/TJP1/ARPC5/TUBA3D/IRAK4/PAK2/ABCF2/CLDN5/ACTR3B/CYTH4/CHUK/CLDN7/CLDN12/OCLN/LPAR5/NLRP3	2.17379099376039
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	7/1494	19/9376	2.31212569576552	HEXB/GALNS/ARSB/HEXA/SGSH/IDS/GNS	2.49245110787836
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	24/1494	100/9376	1.50618473895582	CD59/ITGA1/IL1R2/HLA-DMA/ITGA3/MME/CD7/HLA-DPA1/CSF1/HLA-DPB1/CD37/CSF3R/HLA-DQA1/ITGA6/IL2RA/CD1D/IL1B/CD2/CD9/IL11RA/HLA-DMB/ITGA4/CD22/IL11	2.21549818763646
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/1494	85/9376	1.55048429010158	PNP/UPP1/NUDT16/CDA/ENTPD3/AK1/ENPP1/CMPK1/RRM1/ADK/AK6/AK3/AK2/AK9/ENPP3/NME1/HPRT1/ENTPD5/AK5/CMPK2/DCK	2.21955486069357
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	45/1494	212/9376	1.33212093657649	RASGRP2/CALM2/CNR1/RAP1B/F2R/PDGFRA/MAPK14/SKAP1/TLN2/PLCE1/MRAS/RAP1A/RAC2/SIPA1L1/VAV3/LPAR1/AFDN/CSF1/PDGFC/FYB1/KDR/RALA/TLN1/ANGPT2/PDGFD/RHOA/PIK3CB/PARD6B/ANGPT1/PFN2/CALM3/PIK3CD/ADCY7/EPHA2/ID1/PFN4/TEK/RGS14/ARAP3/LPAR3/RRAS/PDGFB/PLCB2/LPAR5/LAT	2.12943489144421
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	18/1494	71/9376	1.59104021720686	ATP6V0E1/ATP6V0B/ATP6V0C/ATP6V1G1/MAPK14/ATP6V1E1/ATP6AP1/ATP6V1H/ATP6V1C1/ATP6V1F/ATP6V0E2/CCL5/ATP6V1A/TJP1/ATP6V1B2/ATP6V1G2/CHUK/ATP6V0D2	2.17636002701406
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/1494	20/9376	2.19651941097724	CYB5R1/CYB5R3/UGDH/CMAS/GMPPB/TGDS/UAP1L1	2.33202048715648
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	41/1494	193/9376	1.33319460917938	RASGRP2/CCL8/CCL3/CCL23/RAP1B/CCL4/XCL2/GRK3/CXCL14/XCL1/RAP1A/RAC2/ROCK2/ITK/VAV3/CCL2/GRK5/STAT1/CXCR4/CCL14/RHOA/PIK3CB/GNB5/PRKACB/GNGT1/CCL5/PREX1/ARRB2/FGR/PIK3CD/ADCY7/JAK2/CCR10/CCL21/CHUK/CXCR3/CCL13/CCL28/GNGT2/PLCB2/WAS	2.03623102497921
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	15/1494	57/9376	1.65151835411823	TECR/ELOVL1/HACD1/PPT1/ACSL3/CPT1C/HACD4/ACADS/HSD17B12/HACD3/HACD2/ACADM/ELOVL4/ELOVL3/OXSM	2.14794001373704
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	20/1494	82/9376	1.53067554771933	B2M/CTSB/HLA-DMA/CTSL/KLRC1/HSPA2/HLA-E/CD74/KLRC3/KLRC2/HLA-DPA1/HLA-DPB1/HLA-DQA1/KIR2DL4/HLA-A/TAPBP/HLA-DMB/TAPBPL/KIR2DL1/IFNG	2.10124837515284
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1494	34/9376	1.84581463107331	SKP1/NR1D1/RBX1/DBP/PER3/PRKAG1/RORB/FBXL3/PRKAB2/PRKAA2	2.15098529858621
Human Diseases	Immune disease	hsa05330	Allograft rejection	11/1494	39/9376	1.77008890261902	HLA-DMA/GZMB/HLA-E/PRF1/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-A/CD86/HLA-DMB/IFNG	2.09803249698054
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	12/1494	44/9376	1.71157356699525	HLA-DMA/GZMB/HLA-E/PRF1/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-A/IL1B/CD86/HLA-DMB/IFNG	2.05968829865688
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/1494	21/9376	2.09192324854975	CHST7/CHPF/CHST3/CHSY1/CHST13/B3GAT3/CSGALNACT1	2.18083388243129
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/1494	21/9376	2.09192324854975	ENPP1/COASY/ENPP3/PPCS/ALDH3A2/BCAT2/ALDH1B1	2.18083388243129
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	13/1494	49/9376	1.66500013660083	LFNG/GALNT18/ST6GAL2/C1GALT1/GALNT15/EOGT/B4GALT3/GXYLT1/C1GALT1C1/POGLUT1/ST6GAL1/POMT2/GALNT6	2.03184936621471
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1494	54/9376	1.6270514155387	MDH2/ADI1/TST/CISD1/SDSL/AGXT2/GOT2/MAT2B/APIP/CDO1/BHMT2/BCAT2/MDH1/GOT1	2.01181575492766
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1494	59/9376	1.59553468109727	PGD/GGT5/GPX4/MGST1/TXNDC12/MGST2/GPX3/RRM1/GPX8/GSTA1/GSTT2B/G6PD/LANCL1/ODC1/CHAC2	1.99773435184388
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	26/1494	116/9376	1.40663804643863	PGD/H6PD/MCEE/SDHC/ALDOC/MDH2/DLAT/ACSS1/SDSL/AGXT2/G6PD/ACO2/PCCB/PSPH/ACADS/GOT2/GLYCTK/PGAM1/SDHD/PFKM/ADPGK/GPT/MDH1/GOT1/FBP1/SHMT1	1.91855490903643
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	42/1494	204/9376	1.29207024175132	WNT6/WNT4/LUM/DCN/VTN/MMP9/WNT5A/CTSL/PLAUR/PPP1CB/ERBB3/CAV2/MAPK14/SDC2/WNT3/EZR/PLCE1/MRAS/ROCK2/SDC1/VAV3/RRAS2/ITGB5/KDR/ANK3/RHOA/PIK3CB/WNT10B/HCLS1/IGF2/PRKACB/WNT9A/WNT16/CBL/CD63/PIK3CD/TLR2/WNT9B/WNT1/RPS6KB2/RRAS/WNT3A	1.83617086688823
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	16/1494	65/9376	1.54480486046751	PLPP3/PNPLA2/LCLAT1/PLPP5/AGPAT2/AKR1B1/MBOAT2/DGAT1/GLYCTK/LPL/LPIN2/ALDH3A2/DGKE/ALDH1B1/DGAT2/GPAM	1.91885522984999
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	13/1494	50/9376	1.63170013386881	CD81/KLRB1/SDC2/SDC1/KLRK1/CCL2/ACKR1/IL1B/IL18/TLR2/HBA1/SELE/IFNG	1.94980413561977
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	14/1494	55/9376	1.5974686625289	PLPP3/ASAH1/GM2A/HEXB/SPTLC1/CERK/CERS6/PSAP/HEXA/SGPL1/NEU1/SAMD8/SMPD1/CERS4	1.9346746615341
NA	NA	hsa04981	Folate transport and metabolism	9/1494	31/9376	1.82199766809172	MTHFS/FPGS/ABCC1/DHFR/SLC46A1/BHMT2/FOLR1/SLCO2B1/SHMT1	1.99574247871261
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	50/1494	250/9376	1.25515394912985	RAB11FIP1/TGFBR1/WIPF1/ARPC1B/PDGFRA/CAV2/HLA-E/GRK3/IL2RB/CHMP5/SMAP2/RAB31/EHD4/CLTB/VPS37A/SNX5/CAPZA1/ZFYVE16/DAB2/ARAP2/GRK5/TSG101/CXCR4/IL2RA/CAPZA2/RHOA/HLA-A/PARD6B/ASAP2/CHMP2A/ACAP1/AP2S1/SMAP1/KIF5C/SPG21/VPS29/CBL/WASHC3/RAB11B/ARPC5/ARRB2/STAMBP/WASHC1/DNAJC6/FOLR1/ACTR3B/RNF41/CYTH4/ARAP3/CHMP4C	1.78022456002269
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/1494	41/9376	1.68374310249127	MAOA/MAOB/BPGM/SDSL/AGXT2/PSPH/GLYCTK/ALAS1/PGAM1/SHMT1/GAMT	1.91016308206077
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/1494	18/9376	2.09192324854975	AGA/HEXB/HEXA/NEU1/FUCA2/FUCA1	2.01873618024224
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1494	14/9376	2.24134633773188	B4GALT4/B3GNT2/B4GALT3/CHST1/B3GNT7	2.0235567494028
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1494	37/9376	1.69615398531061	UGDH/NAGK/PGM2/GALE/CMAS/UXS1/GMPPB/TGDS/UAP1L1/FPGT	1.84713530709298
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1494	10/9376	2.51030789825971	TST/PAPSS1/ETHE1/SUOX	2.08032476217535
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	7/1494	23/9376	1.91001687911065	ARG1/GLUL/ASL/GOT2/GPT/GOT1/NOS3	1.90230706244173
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/1494	23/9376	1.91001687911065	REN/MME/ATP6AP2/PRCP/CTSA/NLN/AGT	1.90230706244173
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	24/1494	110/9376	1.3692588535962	TGFBR1/DCN/SKP1/RBX1/CHRD/SMAD6/SMAD9/BAMBI/ZFYVE16/PPP2R1B/LTBP1/RHOA/ID3/ACVR1C/BMP8A/EMP3/LEFTY2/HFE/ID1/RPS6KB2/RGMB/IFNG/GREM2/LRRC32	1.69599213279868
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	17/1494	73/9376	1.46148062569914	BST2/SMARCB1/PIN1/MDFIC/MX1/SERINC3/SAMHD1/KAT2B/RANBP2/TSG101/CXCR4/MAP1B/BICD2/SUPT4H1/BICD1/NELFA/CDK9	1.72324137726416
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	15/1494	63/9376	1.49423089182125	POLE4/POLR2K/POLR2L/RBX1/GTF2H5/POLR2I/MNAT1/RAD23A/POLR2J/CCNH/POLR2A/XPC/POLD4/POLE2/DDB2	1.71355513335491
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/1494	33/9376	1.71157356699525	DLAT/AGXT2/ACO2/BCKDHA/GOT2/DHTKD1/GPT/BCAT2/GOT1	1.7826920349031
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/1494	38/9376	1.65151835411823	HEXB/UGDH/NAGK/HEXA/PGM2/GALE/UXS1/GMPPB/UAP1L1/FPGT	1.75200055757434
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	12/1494	48/9376	1.56894243641232	MCEE/AUH/AGXT2/OXCT1/PCCB/BCKDHA/ACADS/ALDH3A2/OXCT2/ACADM/BCAT2/ALDH1B1	1.7204315565736
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	28/1494	133/9376	1.32121468329458	KLRC1/GZMB/TYROBP/FCER1G/HLA-E/KLRC3/PRF1/KLRC2/RAC2/HCST/VAV3/KLRK1/IFNAR2/KIR2DL4/ICAM2/PIK3CB/HLA-A/ZAP70/PPP3CB/IFNGR1/LAT2/IFNAR1/PIK3CD/ULBP2/NCR1/KIR2DL1/IFNG/LAT	1.62426712781042
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	27/1494	128/9376	1.32379518072289	PNP/NUDT16/ENTPD3/NUDT2/AK1/ENPP1/PDE4B/PAPSS1/RRM1/NUDT5/ADK/AK6/AK3/AK2/PGM2/AK9/ENPP3/PDE1A/HDDC3/NME1/HPRT1/ENPP4/ADCY7/NPR1/ENTPD5/AK5/DCK	1.60581006803581
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	32/1494	156/9376	1.28733738372293	CD81/CLDN20/CLDN4/SCARB1/MX1/PPP2R1B/CLDN23/IRF7/IFNAR2/STAT1/YWHAE/IRF9/RSAD2/PIK3CB/CLDN10/IFIT1/CLDN3/YWHAH/EIF2AK2/OAS3/IFNAR1/PIK3CD/RNASEL/CLDN5/OAS2/RXRA/CHUK/CLDN7/CLDN12/IFNG/OCLN/PPP2R2B	1.57554819830729
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1494	15/9376	2.09192324854975	ST6GALNAC3/HEXB/ST3GAL5/HEXA/B3GALT4	1.84255025268728
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	48/1494	248/9376	1.21466511206115	SKP1/DYNLRB1/MYL12A/DCTN6/DYNLT3/ARPC1B/PTPRC/MYL9/ABI1/MAPK14/VPS41/PODXL/TUBA3E/ROCK2/RHOH/DYNLL1/ARL8B/S100A10/ARHGEF26/RALA/SNX18/HSP90B1/TUBA4A/RHOA/PIK3CB/VPS16/IL1B/IL18/PFN2/ACTR10/RHOB/KIF5C/DYNC1LI1/ARPC5/TUBA3D/IRAK4/PIK3CD/TLR2/ACTR1A/BIRC3/ACTR3B/CSE1L/PFN4/CYTH4/VPS33A/CHUK/RRAS/NLRP3	1.49156510271675
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	26/1494	125/9376	1.30536010709505	CTSD/ASAH1/ORMDL2/FCER1G/MAPK14/SPTLC1/MAP3K5/RAC2/ROCK2/CERS6/PPP2R1B/MS4A2/ORMDL1/RHOA/PIK3CB/ABCC1/SGPL1/SMPD1/PIK3CD/CERS4/SPTSSB/KNG1/PLCB2/S1PR4/PPP2R2B/NOS3	1.49628970192812
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/1494	50/9376	1.50618473895582	HLA-DMA/HLA-DPA1/HLA-DPB1/HLA-DQA1/CXCR4/LTBR/CD86/CCR10/HLA-DMB/ITGA4/CCL28/TNFSF13	1.56238861524232
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1494	30/9376	1.6735385988398	FPGS/ABCC1/IL1B/DHFR/SLC46A1/FOLR1/CHUK/SHMT1	1.60861809548626
Organismal Systems	Digestive system	hsa04978	Mineral absorption	14/1494	61/9376	1.44034059736213	SLC40A1/FTH1/ATP1B3/ATP2B3/ATP2B4/HMOX2/SLC39A4/FTL/MT1X/SLC46A1/ATOX1/TRPM6/SLC26A6/ATP7B	1.50212106609387
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	11/1494	46/9376	1.50072754787265	ALAD/FTH1/HMOX2/BLVRB/MMAB/FTL/HCCS/ALAS1/PPOX/CP/UGT2B7	1.48211635845884
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	17/1494	78/9376	1.36779597020561	IP6K3/IMPA2/ITPKC/PLCE1/ITPK1/MINPP1/FIG4/PIK3CB/PPIP5K2/PIK3CD/IMPA1/MTMR6/CDIPT/ISYNA1/INPP5K/PLCD4/PLCB2	1.42004536495312
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/1494	78/9376	1.36779597020561	HLA-DMA/CYBA/MAPK14/HLA-DPA1/HLA-DPB1/STAT1/HLA-DQA1/C3/IL1B/IFNGR1/IRAK4/JAK2/TLR2/HLA-DMB/ITGA4/NCF4/IFNG	1.42004536495312
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	9/1494	36/9376	1.56894243641232	ENPP1/GAA/PGM2/G6PC3/ENPP3/PYGL/GYG1/PGM2L1/PYGM	1.48897999258221
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1494	12/9376	2.09192324854975	VKORC1/VKORC1L1/GGCX/COQ6	1.647763031559
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1494	42/9376	1.49423089182125	SLC40A1/SAT1/GPX4/NCOA4/FTH1/FTL/ACSL3/SLC3A2/CP/MAP1LC3C	1.39753713289371
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1494	17/9376	1.84581463107331	PCDH20/MYH10/LAMP1/DAG1/PCDH7	1.51959428694594
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	35/1494	181/9376	1.21354663589903	CTSD/CALM2/ATP6V0B/CAMP/HLA-DMA/ATP6V0C/FCER1G/CD74/MAPK14/CORO1A/ATP6AP1/ATP6V1H/HLA-DPA1/HLA-DPB1/STAT1/HLA-DQA1/LAMP1/RHOA/MRC2/C3/IL1B/IL18/PLA2R1/PPP3CB/CALM3/IFNGR1/IRAK4/JAK2/TLR2/HLA-DMB/CARD9/IL10RB/CEBPG/ATP6V0D2/IFNG	1.2629869887558
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/1494	75/9376	1.33883087907184	ARG1/GLUL/PYCR2/ALDOC/ASL/SDSL/ACO2/PSPH/GOT2/MAT2B/PGAM1/PFKM/GPT/BCAT2/GOT1/SHMT1	1.28260082140799
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	21/1494	103/9376	1.27952587047218	TGFBR1/CCL3/SERPINE1/MAPK14/C1QB/PPP2R1B/CCL2/PIK3CB/C3/IL1B/CCL5/IFNGR1/IRAK4/PIK3CD/TLR2/GNA15/CHUK/KNG1/IFNG/PLCB2/PPP2R2B	1.24186164114486
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	13/1494	59/9376	1.38279672361763	UPP1/CDA/ENTPD3/NUDT2/ENPP1/CMPK1/RRM1/AK9/ENPP3/NME1/ENTPD5/CMPK2/DCK	1.28410013525196
NA	NA	hsa04517	IgSF CAM signaling	55/1494	299/9376	1.15440580605588	NECTIN2/NFASC/UNC5B/PPFIA1/MYL12A/RAP1B/MYH10/KCNA4/ARPC1B/PTPRD/NCAM1/NCK1/MYL9/MAPK14/MYLK3/TUBA3E/PVR/EZR/CD96/LMO7/MPDZ/RAP1A/VAV3/DYNLL1/AFDN/DOK2/KDR/EPB41L1/ANK3/TUBA4A/ICAM2/RHOA/PIK3CB/TRPC6/CABLES1/PARD6B/SORBS1/TJP1/CD2/ARPC5/TUBA3D/CDH2/PAK2/PIK3CD/CD226/FGG/CD86/ROBO2/CD84/ACTR3B/NLGN2/ITGA4/CRTAM/MYLK/NRCAM	1.18132875406412
Organismal Systems	Immune system	hsa04611	Platelet activation	25/1494	126/9376	1.24519240985104	RASGRP2/MYL12A/RAP1B/PPP1CB/F2R/FCER1G/MAPK14/TLN2/MYLK3/RAP1A/ROCK2/VAMP8/SNAP23/TLN1/PTGIR/RHOA/PIK3CB/PRKACB/PIK3CD/ADCY7/FGG/MYLK/PLA2G4D/PLCB2/NOS3	1.20632450465535
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	16/1494	76/9376	1.32121468329458	APOA1/APOC3/PLIN1/FABP5/ANGPTL4/ACSL3/OLR1/CPT1C/SORBS1/LPL/CYP27A1/APOA5/ACADM/FABP4/RXRA/SLC27A6	1.2240620483172
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	21/1494	104/9376	1.26722273710226	PLPP3/CHPT1/PEMT/LCLAT1/PLPP5/AGPAT2/PISD/LPCAT2/MBOAT2/LYPLA1/MBOAT7/PLD4/SAMD8/LPIN2/PCYT2/DGKE/CDIPT/PLA2G4D/ETNK2/PLA2G15/GPAM	1.19301550473313
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	33/1494	173/9376	1.19711214801402	HLA-DMA/SLC25A4/MX1/HLA-DPA1/CCL2/IFIH1/HLA-DPB1/IRF7/IFNAR2/STAT1/HLA-DQA1/IRF9/RSAD2/PIK3CB/IL1B/CCL5/IL18/EIF2AK2/CCND3/IFNGR1/OAS3/RAB11B/IFNAR1/IRAK4/PIK3CD/JAK2/RNASEL/HLA-DMB/OAS2/NXT2/CHUK/IFNG/NLRP3	1.13923797424607
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/1494	66/9376	1.33122388544075	HLA-DMA/STAT4/HLA-DPA1/HLA-DPB1/IL18R1/STAT1/HLA-DQA1/IL1B/IL18/IFNGR1/TLR2/HLA-DMB/IL21R/IFNG	1.17560519441008
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	32/1494	169/9376	1.18831143112885	CTSD/CTSB/RHEB/CTSL/GABARAPL2/DEPTOR/GABARAP/ATG9B/VPS41/MRAS/SNAP29/VAMP8/RRAS2/LAMP1/STX7/RAB1A/PIK3CB/VPS16/PRKACB/TAX1BP1/ATG4A/ATG4D/NBR1/YKT6/PIK3CD/ATG2B/RPS6KB2/MAP1LC3C/VPS33A/RRAS/RRAGD/PRKAA2	1.07548333775449
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/1494	67/9376	1.31135487222522	ALDOC/MINPP1/DLAT/BPGM/PGM2/GALM/G6PC3/ACSS1/PGAM1/PFKM/ADPGK/ALDH3A2/ALDH1B1/FBP1	1.11348475153699
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/1494	35/9376	1.4344616561484	HSD17B14/ALDOC/AKR1B1/TIGAR/PFKM/GMPPB/FPGT/FBP1	1.12106685138854
NA	NA	hsa04518	Integrin signaling	29/1494	154/9376	1.18180079625863	ITGA1/VTN/COL4A6/ITGA3/PARVA/FERMT2/PDGFRA/TLN2/LIMS2/ITGAD/LAMC3/RAC2/ITGAE/ITGB5/PDGFC/KDR/ITGA6/TLN1/PDGFD/ICAM2/PIK3CB/C3/CCND3/PARVB/PIK3CD/FGG/ITGA4/FREM1/PDGFB	0.990344523184202
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/1494	137/9376	1.19102199552468	CTSD/CTSB/CTSL/CTSZ/GZMB/PTPN13/TUBA3E/CTSW/PRF1/CTSO/MAP3K5/NOL3/CTSH/NTRK1/CSF2RB/TUBA4A/DAB2IP/PIK3CB/PARP4/PARP1/GADD45G/TUBA3D/PIK3CD/CTSV/BIRC3/CHUK	0.980559381919208
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	34/1494	184/9376	1.15965310517432	SEMA3A/SEMA3B/WNT4/UNC5B/SEMA3C/WNT5A/MYL12A/SEMA7A/NCK1/SEMA4D/MYL9/ABLIM3/DPYSL2/CFL2/RAC2/ABLIM2/ROCK2/SEMA6D/RGS3/CXCR4/RHOA/PIK3CB/TRPC6/PARD6B/PPP3CB/SEMA3G/NTN4/PAK2/PIK3CD/SEMA6A/ROBO2/EPHA2/SEMA3E/RRAS	0.95219083085878
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	28/1494	149/9376	1.17933928106161	PLPP3/RHEB/F2R/FCER1G/PDGFRA/MRAS/AGPAT2/LPAR1/RRAS2/MS4A2/PDGFC/RALA/GRM7/PDGFD/RHOA/PIK3CB/PIK3CD/ADCY7/AGT/DGKE/CYTH4/PLA2G4D/AVPR1A/LPAR3/RRAS/PDGFB/PLCB2/LPAR5	0.960685022679545
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	59/1494	333/9376	1.11192316814807	WNT6/WNT4/ATP6V0E1/ITGA1/ISG15/LFNG/VTN/ATP6V0B/COL4A6/RHEB/ITGA3/ATP6V0C/WNT5A/BCAP31/ATP6V1G1/HLA-E/MAML3/ATP6V1E1/MX1/WNT3/LAMC3/ATP6AP1/ATP6V1H/ATP6V1C1/PPP2R1B/CREB3L1/ATP6V1F/IFNAR2/STAT1/ITGB5/IRF9/ITGA6/TBPL1/ATP6V0E2/PIK3CB/WNT10B/HLA-A/PRKACB/PARD6B/ATP6V1A/WNT9A/WNT16/EIF2AK2/CCND3/TUBG1/IFNAR1/PIK3CD/ATP6V1B2/OASL/ATP6V1G2/WNT9B/WNT1/ITGA4/RPS6KB2/HEYL/CHUK/ATP6V0D2/WNT3A/PPP2R2B	0.905375145498369
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	21/1494	109/9376	1.20909325374894	TGFBR1/HLA-DMA/IL2RB/MAPK14/HLA-DPA1/HLA-DPB1/STAT1/HLA-DQA1/IL2RA/IL1B/ZAP70/PPP3CB/IFNGR1/IL6ST/JAK2/HLA-DMB/RXRA/CHUK/IL21R/IFNG/LAT	0.955930701398689
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	26/1494	138/9376	1.18239140135421	WIPF1/ARPC1B/MAPK14/RPS6KA2/RAC2/ROCK2/VAV3/CCL2/SKAP2/FYB1/RHOA/PIK3CB/WASF2/IL1B/ZAP70/IL18/ARPC5/IRAK4/PIK3CD/ACTR3B/ITGA4/RPS6KA1/CHUK/LAT/WAS/NLRP3	0.939718217119147
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	42/1494	232/9376	1.13613072981581	RGCC/ITGA1/ITGA3/MYL12A/MYH10/PPP1CB/ARPC1B/F2R/PDGFRA/MYL9/MYLK3/EZR/CFL2/ITGAD/MRAS/RAC2/ITGAE/ROCK2/VAV3/LPAR1/RRAS2/ITGB5/PDGFC/ITGA6/CXCR4/PDGFD/RHOA/PIK3CB/WASF2/PFN2/ARPC5/PAK2/PIK3CD/ACTR3B/ITGA4/SCIN/PFN4/MYLK/RRAS/KNG1/PDGFB/LPAR5	0.91406015570864
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	31/1494	168/9376	1.15802894116147	PRL/PRLR/PDGFRA/IL2RB/STAT4/CISH/CSF3R/IFNAR2/STAT1/IRF9/LEPR/CSF2RB/IL2RA/PIK3CB/CCND3/IFNGR1/IFNAR1/IL6ST/IL11RA/PIK3CD/JAK2/OSM/CNTFR/IL10RB/GHR/IL21R/IL11/IFNG/PDGFB/IL13RA2/CTF1	0.899811081683809
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	17/1494	87/9376	1.22629983535675	MT-CO2/UQCR11/COX7B/UQCR10/UQCRQ/COX7A2/COX8A/COX7A2L/ATP1B3/COX6A1/COX6B1/CACNA2D3/COX7A1/COX5B/COX6C/UQCRC1/COX5A	0.923213410835689
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1494	70/9376	1.25515394912985	SGCE/HLA-DMA/HLA-E/SGCB/PRF1/RAC2/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-A/CD86/HLA-DMB/DAG1/SGCZ	0.932851495417593
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	18/1494	93/9376	1.21466511206115	TGFBR1/NECTIN2/MYL12A/RAP1B/MYL9/PTPRJ/LMO7/RAP1A/RAC2/ROCK2/AFDN/CSNK2B/RHOA/WASF2/SORBS1/TJP1/CDH5/WAS	0.905735704613947
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	18/1494	93/9376	1.21466511206115	HLA-DMA/MAML3/IL2RB/STAT4/MAPK14/HLA-DPA1/HLA-DPB1/STAT1/HLA-DQA1/IL2RA/ZAP70/PPP3CB/IFNGR1/JAK2/HLA-DMB/CHUK/IFNG/LAT	0.905735704613947
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	29/1494	157/9376	1.1592186154384	WNT6/TGFBR1/NKD1/WNT4/CRB2/WNT5A/PPP1CB/SERPINE1/WNT3/AREG/PPP2R1B/YWHAE/DLG5/WNT10B/BMP8A/PARD6B/YWHAH/WNT9A/WNT16/NKD2/CCND3/BIRC3/WNT9B/WNT1/ID1/WWC1/CRB1/WNT3A/PPP2R2B	0.87587974523424
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	19/1494	99/9376	1.20444065825592	PLPP3/RHEB/CHPT1/PDGFRA/SLC44A2/RAC2/SLC44A1/PDGFC/LYPLA1/PDGFD/PIK3CB/WASF2/SLC22A1/PIK3CD/DGKE/RPS6KB2/PLA2G4D/PDGFB/WAS	0.890274248217181
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/1494	134/9376	1.1708525644868	CALM2/KCNMB4/MYH10/ADM/PPP1CB/PRKCH/MYL9/MYLK3/ROCK2/RAMP1/PTGIR/CALD1/RHOA/PRKACB/CALM3/ADCY7/NPR1/KCNMA1/AGT/RAMP3/MYLK/PLA2G4D/AVPR1A/PLCB2/ACTG2	0.867228697490819
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	34/1494	187/9376	1.1410490446635	CTSB/CAMP/CYBA/GABARAPL2/GABARAP/MAPK14/CCL2/ANTXR1/GPSM3/IRF7/IFNAR2/STAT1/YWHAE/IRF9/RHOA/IL1B/CCL5/IL18/DHX33/OAS3/IFNAR1/IRAK4/ANTXR2/RNASEL/BIRC3/CARD9/OAS2/MAP1LC3C/TRPV2/PSTPIP1/CHUK/PLCB2/TRPM2/NLRP3	0.84820250000132
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1494	37/9376	1.35692318824849	GLUL/ALDH5A1/ASL/RIMKLB/AGXT2/GOT2/GPT/GOT1	0.947039644741556
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	8/1494	37/9376	1.35692318824849	MAOA/MAOB/COMT/FAH/TH/GSTZ1/GOT2/GOT1	0.947039644741556
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/1494	37/9376	1.35692318824849	APOA1/IL1B/IL18/HBA1/KNG1/SELE/IFNG/PLCB2	0.947039644741556
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1494	37/9376	1.35692318824849	CCDC6/NCOA4/NTRK1/TFG/GADD45G/RET/RXRA/DDB2	0.947039644741556
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/1494	32/9376	1.37282463186078	AKR1B1/GAA/PGM2/GALM/G6PC3/GALE/PFKM	0.919720556961383
Human Diseases	Immune disease	hsa05310	Asthma	7/1494	32/9376	1.37282463186078	HLA-DMA/FCER1G/HLA-DPA1/MS4A2/HLA-DPB1/HLA-DQA1/HLA-DMB	0.919720556961383
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1494	16/9376	1.56894243641232	MAOA/MAOB/GOT2/GOT1	0.991592234200961
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1494	16/9376	1.56894243641232	HEXB/HEXA/NAGA/B3GALNT1	0.991592234200961
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	17/1494	89/9376	1.19874253568581	HTR2B/PDGFRA/TUBA3E/MAPK7/GJA1/LPAR1/PDGFC/MAP3K2/PDGFD/TUBA4A/PRKACB/TJP1/TUBA3D/ADCY7/HTR2A/PDGFB/PLCB2	0.820145353485471
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/1494	101/9376	1.18059034819145	TGFBR1/COL4A6/F3/SERPINE1/MAPK14/PLCE1/CCL2/STAT1/PIK3CB/IL1B/THBD/PIK3CD/JAK2/AGT/PLCD4/SELE/PLCB2/NOX4/NOS3	0.794403199753972
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1494	38/9376	1.32121468329458	PNP/BST1/ENPP1/NMRK1/QPRT/ENPP3/NUDT12/SIRT7	0.863779662807552
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	41/1494	233/9376	1.10431999816146	DCN/ITGA1/FBN2/NID2/COL4A6/SGCE/PKP2/ITGA3/DAAM1/MYH10/FMNL2/MYL9/TLN2/SGCB/SDC2/SUN2/CAPZA1/COL24A1/SDC1/PDLIM1/ATP1B3/ITGB5/FHL2/ITGA6/TLN1/CAPZA2/ANK3/NEBL/DAAM2/NEB/DES/PDLIM4/CSRP2/PDLIM2/DAG1/ITGA4/SGCZ/SYNE3/JUP/ACTG2/MYOM2	0.702010960844931
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1494	17/9376	1.47665170485865	CYP39A1/CYP7B1/CYP27A1/ACOT8	0.856354549751771
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1494	17/9376	1.47665170485865	PAPSS1/TXNRD2/TXNRD3/INMT	0.856354549751771
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1494	28/9376	1.34480780263913	B4GALT4/B3GNT2/B4GALT3/ST3GAL6/B3GNT5/B3GALNT1	0.795498692887915
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1494	51/9376	1.23054308738221	PLPP3/PLA2G7/CHPT1/LPCAT2/PLD4/ENPP2/PLA2G4D/PAFAH2/TMEM86A/PAFAH1B3	0.718712989945808
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1494	34/9376	1.29207024175132	POLR2K/POLR2L/POLR2I/POLR3GL/POLR2J/POLR2A/POLR3K	0.74276179801287
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	20/1494	110/9376	1.1410490446635	RBX1/SERPINE1/EPAS1/ALDOC/ELOB/EIF4E/ANGPT2/PIK3CB/LTBR/ANGPT1/EGLN2/PDK1/MKNK1/IFNGR1/PIK3CD/PFKM/RPS6KB2/TEK/IFNG/NOS3	0.647832997796345
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/1494	63/9376	1.195384713457	WNT6/WNT4/WNT5A/WNT3/WNT10B/WNT9A/WNT16/GADD45G/WNT9B/WNT1/DDB2/WNT3A	0.677421189698544
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	13/1494	70/9376	1.16550009562058	ADIPOR1/ACACB/LEPR/G6PC3/ACSL3/CPT1C/PRKAG1/JAK2/PRKAB2/RXRA/CHUK/POMC/PRKAA2	0.605073965023524
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	25/1494	142/9376	1.10488903972698	SKP1/RBX1/UBE2D1/UBE2M/UBE2W/ELOB/KLHL13/ANAPC16/RCHY1/ANAPC13/ANAPC10/CBL/UBA3/CDC23/UBE2N/UBE2L6/UBE2F/UBE2D4/BIRC3/ANAPC15/STUB1/UBE2U/DDB2/UBE2QL1/FBXO2	0.548304825680086
NA	NA	hsa04519	Cadherin signaling	68/1494	404/9376	1.05631767996077	KRT23/WNT6/WNT4/PCDH20/PKP2/DAAM1/WNT5A/PPP1CB/LIMA1/ARPC1B/PDGFRA/KRT18/MAPK14/WNT3/NCSTN/MPDZ/MRAS/MYO1B/APH1B/RAC2/GJA1/ROCK2/PCDH19/VAV3/MYO1D/PSENEN/AFDN/KRT81/RRAS2/PCDHB16/TMIE/YWHAE/KRT8/KDR/RHOA/PSEN2/WNT10B/DAAM2/YWHAH/WNT9A/WNT16/TJP1/ARPC5/DES/CDH2/KRT86/GABRB3/TMC8/ACTR3B/KRT7/PCDH17/WNT9B/WNT1/PCDHB6/KRT10/WWC1/PCDHGA2/CDH5/PCDHGB6/CHUK/PCDH7/CDH11/CELSR1/RRAS/PCDHGB7/PCDHGA1/JUP/WNT3A	0.503771422127378
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	35/1494	203/9376	1.08202926649125	ITGA1/VTN/COL4A6/ITGA3/EMP2/MYL12A/RAP1B/PPP1CB/PARVA/PDGFRA/CAV2/MYL9/TLN2/MYLK3/LAMC3/RAP1A/RAC2/ROCK2/VAV3/ITGB5/PDGFC/KDR/ITGA6/TLN1/PDGFD/RHOA/PIK3CB/CCND3/PARVB/PAK2/PIK3CD/BIRC3/ITGA4/MYLK/PDGFB	0.514403449191323
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	61/1494	362/9376	1.05751921128344	PRL/ITGA1/VTN/PRLR/COL4A6/RHEB/SGK1/ITGA3/F2R/ERBB3/PDGFRA/IL2RB/AREG/LAMC3/LPAR1/PPP2R1B/CSF1/CREB3L1/CSF3R/IFNAR2/NTRK1/ITGB5/YWHAE/PDGFC/EIF4E/KDR/ITGA6/IL2RA/ANGPT2/HSP90B1/PDGFD/G6PC3/PIK3CB/GNB5/IGF2/PIK3AP1/GNGT1/ANGPT1/YWHAH/RET/CCND3/IFNAR1/PIK3CD/JAK2/TLR2/ATF6B/OSM/EPHA2/GHR/ITGA4/RPS6KB2/RXRA/TEK/CHUK/LPAR3/GNGT2/PDGFB/LPAR5/PRKAA2/PPP2R2B/NOS3	0.485904758705545
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	19/1494	107/9376	1.11438902025548	CALM2/PHKG1/ACACB/CREB3L1/G6PC3/PRKACB/CPT1C/PPP3CB/PRKAG1/PHKA1/CALM3/PYGL/PGAM1/PFKM/PRKAB2/FBP1/PYGM/PLCB2/PRKAA2	0.518086778988429
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	18/1494	101/9376	1.11845401407611	WNT6/WNT4/CALM2/WNT5A/EDNRB/WNT3/CREB3L1/WNT10B/PRKACB/WNT9A/WNT16/CALM3/ADCY7/WNT9B/WNT1/POMC/PLCB2/WNT3A	0.521070194216606
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1494	30/9376	1.25515394912985	SDHC/MDH2/DLAT/ACO2/SDHD/MDH1	0.60938639658079
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1494	36/9376	1.22028856165402	ST6GALNAC3/GALNT18/GCNT1/C1GALT1/GALNT15/C1GALT1C1/GALNT6	0.576517482095228
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/1494	42/9376	1.195384713457	MAOA/MAOB/KYNU/INMT/DHTKD1/ALDH3A2/ALDH1B1/KMO	0.552489528223812
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	24/1494	138/9376	1.09143821663465	CALM2/RHEB/PPP1CB/PHKG1/ACACB/EIF4E/PRKAR2B/G6PC3/PIK3CB/PRKACB/PRKAG1/PHKA1/MKNK1/CBL/CALM3/SORBS1/PYGL/PIK3CD/PPP1R3D/PRKAB2/RPS6KB2/FBP1/PYGM/PRKAA2	0.471108600923576
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/1494	54/9376	1.16217958252764	HLA-DMA/GZMB/HLA-E/PRF1/HLA-DPA1/HLA-DPB1/HLA-DQA1/HLA-A/CD86/HLA-DMB	0.520332832637651
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	12/1494	66/9376	1.1410490446635	CYP3A5/COMT/HSD11B1/DHRS9/SRD5A3/CYP7B1/HSD17B6/HSD17B12/HSD17B7/HSD17B1/SULT2B1/UGT2B7	0.500622077276651
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1494	19/9376	1.32121468329458	DLAT/BCKDHA/DHTKD1/LIPT2	0.610164023026229
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/1494	109/9376	1.09394151529666	PPP1CB/TBC1D4/RPS6KA2/ACACB/CREB3L1/G6PC3/PIK3CB/PRKAG1/PYGL/PIK3CD/PPP1R3D/PRKAB2/AGT/RPS6KB2/RPS6KA1/PYGM/SLC27A6/PRKAA2/NOS3	0.429480994713573
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	24/1494	140/9376	1.0758462421113	TGFBR1/CALM2/PLIN1/SERPINE1/KLF2/MYLK3/MRAS/RRAS2/MEF2A/GNB5/PRKACB/GNGT1/PRKAG1/CALM3/ADCY7/PRKAB2/RPS6KB2/MAP1LC3C/MYLK/RRAS/GNGT2/PLCB2/PRKAA2/NOS3	0.393639657653247
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	40/1494	238/9376	1.05475121775618	RASGRP2/CALM2/ETS2/RAP1B/PDGFRA/RGL1/PLCE1/MRAS/RAP1A/RAC2/RALBP1/AFDN/RRAS2/CSF1/NTRK1/PDGFC/KDR/RALA/ANGPT2/PDGFD/RHOA/PIK3CB/GNB5/IGF2/PRKACB/GNGT1/ZAP70/ANGPT1/CALM3/PAK2/PIK3CD/EPHA2/RIN1/TEK/CHUK/PLA2G4D/RRAS/GNGT2/PDGFB/LAT	0.372476953360933
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/1494	98/9376	1.08865393546977	PLPP3/ARPC1B/PTPRC/CFL2/RAC2/VAV3/PIK3CB/WASF2/ASAP2/ARPC5/PIK3CD/ACTR3B/RPS6KB2/SCIN/PLA2G4D/LAT/WAS	0.384084335028593
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	17/1494	98/9376	1.08865393546977	CALM2/SCARB1/ATP1B3/ATP2B3/CACNA1G/CREB3L1/ATP2B4/DAGLB/PRKACB/CALM3/ADCY7/NPR1/ATF6B/AGT/DAGLA/POMC/PLCB2	0.384084335028593
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/1494	86/9376	1.09461100214813	ITGA1/SGCE/PKP2/ITGA3/SGCB/GJA1/ITGB5/ITGA6/CACNA2D3/DES/CDH2/DAG1/ITGA4/SGCZ/JUP	0.38372998173605
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1494	26/9376	1.20687879724024	APOA1/BTD/SCARB1/ABCC1/SLC46A1	0.459874758581952
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1494	32/9376	1.17670682730924	MCEE/ACACB/ACSS1/PCCB/BCKDHA/ACADS	0.435917822329991
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1494	32/9376	1.17670682730924	GABARAPL2/GABARAP/ATG9B/ATG4A/ATG4D/ATG2B	0.435917822329991
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	8/1494	44/9376	1.1410490446635	POLE4/UNG/SMUG1/PARP4/PARP1/NEIL2/POLD4/POLE2	0.408274112902912
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/1494	44/9376	1.1410490446635	VAMP2/DCTN6/ARHGDIB/DYNLL1/CREB3L1/PRKACB/RAB11B/DYNC1LI1	0.408274112902912
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	17/1494	99/9376	1.07765743107109	CALM2/HTR2B/PPP1CB/PRKCH/MAPK14/NTRK1/PIK3CB/PRKACB/IL1B/CALM3/PIK3CD/ADCY7/TRPV2/PLA2G4D/HTR2A/KNG1/PLCB2	0.338173490807016
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	24/1494	142/9376	1.0606934781379	TGFBR1/CYBA/LILRB3/TYROBP/MAPK14/FOSL2/CSF1/IFNAR2/STAT1/FHL2/IRF9/PIK3CB/IL1B/PPP3CB/IFNGR1/IFNAR1/ACP5/PIK3CD/TEC1/CHUK/NCF4/SIRPA/TNFRSF11A/IFNG	0.317273635424087
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	36/1494	216/9376	1.04596162427488	APOA1/CALM2/MMP9/CYBA/CCL3/RAP1B/HSPA2/MAPK14/MAP3K5/RAP1A/ROCK2/VAV3/CCL2/IRF7/ATF6/HSP90B1/RHOA/PIK3CB/IL1B/CCL5/IL18/OLR1/PPP3CB/CALM3/IRAK4/PIK3CD/JAK2/TLR2/RXRA/CHUK/CYP2A6/NCF4/SELE/PLCB2/NLRP3/NOS3	0.297520728386451
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	13/1494	75/9376	1.08780008924587	CD82/IGFBP3/SERPINE1/AIFM2/CCNG2/RCHY1/TP53I3/SESN1/PERP/ZMAT3/GADD45G/CCND3/DDB2	0.332355973265864
Organismal Systems	Endocrine system	hsa04924	Renin secretion	12/1494	69/9376	1.09143821663465	CALM2/CTSB/REN/PRKACB/PDE1A/PPP3CB/CALM3/NPR1/KCNMA1/AQP1/AGT/PLCB2	0.33188693569198
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	34/1494	205/9376	1.04085937244915	B2M/ISG15/HLA-DMA/ENTPD3/HLA-E/MAPK14/PSMD3/HLA-DPA1/HLA-DPB1/IRF7/IFNAR2/STAT1/HLA-DQA1/IRF9/CD58/PIK3CB/HLA-A/TAPBP/GADD45G/PSMD6/SAP30/EIF2AK2/CCND3/OAS3/IFNAR1/IRAK4/PIK3CD/TLR2/HLA-DMB/OAS2/ADRM1/CHUK/DDB2/TAPBPL	0.25751527645611
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1494	27/9376	1.16217958252764	ALDH5A1/OXCT1/ACADS/OXCT2/BDH1	0.367399196367412
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1494	15/9376	1.25515394912985	AK1/AK2/AK5	0.430555878417077
Cellular Processes	Cell motility	hsa04814	Motor proteins	32/1494	194/9376	1.03517851474627	DYNLRB1/MYL12A/MYH10/DCTN6/DYNLT3/MYL9/TUBA3E/MYO1B/DNAI1/CAPZA1/TUBE1/MYO1D/DYNLL1/MYO5A/CAPZA2/KIF26B/TUBA4A/DNALI1/DNAH14/KIF22/ACTR10/KIF5C/TUBG1/DYNC1LI1/TUBA3D/KIF21A/DNAH5/ACTR1A/DNAH11/BICDL1/ACTG2/KIF21B	0.215552191086414
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	20/1494	120/9376	1.04596162427488	CALM2/RAP1B/MAPK14/RPS6KA2/MAPK7/ARHGDIB/MAP3K5/RAP1A/NTRK1/YWHAE/RHOA/PIK3CB/PSEN2/MATK/CALM3/IRAK4/PIK3CD/SORT1/MAGED1/RPS6KA1	0.220605857654992
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	14/1494	83/9376	1.0585635715553	PEX11A/PEX7/DECR2/MPV17/HACL1/PEX3/NUDT7/ACSL3/PEX19/PEX11B/NUDT12/PEX6/ACOT8/MPV17L2	0.233308925749895
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/1494	83/9376	1.0585635715553	POLR2K/CCL4/POLR2L/POLR3GL/IRF7/SAMHD1/POLR3K/IL1B/CCL5/IL18/ZDHHC1/CHUK/ZBP1/NLRP3	0.233308925749895
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1494	65/9376	1.06205334157141	KCNA4/SCARB1/CACNA1G/CREB3L1/NCEH1/PRKACB/ADCY7/ATF6B/AGT/POMC/PLCB2	0.218557850056252
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1494	59/9376	1.06368978739818	PLIN1/ABHD5/PNPLA2/PIK3CB/PRKACB/PIK3CD/ADCY7/NPR1/PTGER3/FABP4	0.213648810364071
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1494	22/9376	1.1410490446635	MAOA/MAOB/ALDH3A2/ALDH1B1	0.288353699915751
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/1494	78/9376	1.04596162427488	ARPC1B/CAV2/CLTB/ARHGEF26/RHOA/PIK3CB/HCLS1/WASF2/SEPTIN6/CBL/ARPC5/PIK3CD/ACTR3B	0.177455972344586
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	29/1494	178/9376	1.02245686867319	LGR4/WNT6/NKD1/WNT4/SKP1/DAAM1/WNT5A/DKK1/RBX1/WNT3/RAC2/BAMBI/ROCK2/TLE6/CSNK2B/RHOA/WNT10B/PRKACB/DAAM2/PPP3CB/WNT9A/WNT16/NKD2/CCND3/WNT9B/WNT1/CELSR1/PLCB2/WNT3A	0.131690734360608
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1494	47/9376	1.06821612691902	HAGH/ACACB/MDH2/DLAT/ACSS1/ALDH3A2/MDH1/ALDH1B1	0.20410853338125
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	20/1494	122/9376	1.02881471240152	RHEB/ADIPOR1/CAB39L/ACACB/PPP2R1B/CREB3L1/LEPR/G6PC3/PIK3CB/CPT1C/PRKAG1/RAB11B/PIK3CD/PFKM/PRKAB2/STRADB/RPS6KB2/FBP1/PRKAA2/PPP2R2B	0.139467231077912
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	27/1494	166/9376	1.02075772971404	CALM2/KCNMB4/PPP1CB/SLC25A4/MYL9/EDNRB/MYLK3/ROCK2/ATP1B3/ATP2B3/CREB3L1/ATP2B4/RHOA/MEF2A/PPIF/TRPC6/KCNJ8/PPP3CB/CALM3/ADCY7/NPR1/ATF6B/KCNMA1/MYLK/KNG1/PLCB2/NOS3	0.117475365066086
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1494	60/9376	1.04596162427488	MAPK14/RAC2/SH2D2A/KDR/PIK3CB/MAPKAPK3/PPP3CB/PIK3CD/PLA2G4D/NOS3	0.155488751037541
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	16/1494	98/9376	1.02461546867743	CALM2/IP6K3/IMPA2/ITPKC/PLCE1/ITPK1/PIK3CB/PPIP5K2/CALM3/PIK3CD/IMPA1/MTMR6/DGKE/CDIPT/PLCD4/PLCB2	0.106644063439372
Human Diseases	Infectious disease: viral	hsa05162	Measles	22/1494	136/9376	1.01519804709032	IL2RB/MX1/CD46/IFIH1/IRF7/IFNAR2/STAT1/IRF9/RCHY1/IL2RA/CSNK2B/PIK3CB/IL1B/EIF2AK2/CCND3/OAS3/IFNAR1/IRAK4/PIK3CD/TLR2/OAS2/CHUK	0.0777255808171206
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/1494	67/9376	1.03035025674839	CALM2/RAP1B/PPP1CB/RPS6KA2/RAP1A/PRKACB/PPP3CB/CALM3/GRIN2D/RPS6KA1/PLCB2	0.108540289904684
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1494	23/9376	1.09143821663465	B4GALT3/B4GAT1/POMT2/FKTN	0.191143229619185
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1494	23/9376	1.09143821663465	ATP1B3/AQP1/MDH1/CA2	0.191143229619185
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/1494	105/9376	1.01607700643845	CITED2/GABARAPL2/GABARAP/ATG9B/MRAS/AMFR/FUNDC1/RRAS2/CSNK2B/TAX1BP1/NBR1/MTX2/PINK1/FKBP8/MAP1LC3C/RRAS/BNIP3L	0.0721239105955837
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/1494	105/9376	1.01607700643845	CALM2/FCER1G/MAPK14/MRAS/RRAS2/STAT1/IRF9/RHOA/PIK3CB/IL1B/PPP3CB/CALM3/PIK3CD/CARD9/CHUK/RRAS/NLRP3	0.0721239105955837
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/1494	99/9376	1.01426581747867	CFH/KRT23/CAMP/HLA-DMA/KRT18/C1QB/SELPLG/HLA-DPA1/MASP1/HLA-DPB1/HLA-DQA1/C3/DEFB1/FGG/HLA-DMB/KRT10	0.0621231121019329
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1494	36/9376	1.04596162427488	POLE4/RNASEH2C/POLD4/POLE2/MCM5/MCM2	0.120286226851739
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1494	17/9376	1.10748877864399	GLUL/CA12/CA2	0.193114812557602
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/1494	112/9376	1.00860585197935	HLA-DMA/MAPK14/LAMC3/HLA-DPA1/HLA-DPB1/STAT1/HLA-DQA1/ITGA6/PPIF/IFNGR1/IRAK4/JAK2/TLR2/HLA-DMB/BIRC3/IL10RB/CHUK/IFNG	0.0398883738684857
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1494	49/9376	1.02461546867743	MAOA/MAOB/GPSM1/CREB3L1/TH/PRKACB/ATF6B/GRIN2D	0.0752103972293435
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/1494	119/9376	1.00201365686837	MMP9/MAPK14/MAP3K5/CCL2/CSF1/CREB3L1/IL18R1/BAG4/MMP14/DAB2IP/PIK3CB/IL1B/CCL5/PIK3CD/ATF6B/BIRC3/CHUK/SELE/RHBDF2	0.00962424207856247
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1494	62/9376	1.01222092671762	CRYAB/PIK3CB/PRKACB/CLPB/PRKAG1/PIK3CD/ADCY7/PRKAB2/RPS6KB2/PRKAA2	0.0420314709971441
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1494	43/9376	1.02163693533825	ECI1/ACSL3/CPT1C/ACADS/ALDH3A2/ACADM/ALDH1B1	0.0619101795789777
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/1494	43/9376	1.02163693533825	APOA1/PLPP3/SCARB1/AGPAT2/DGAT1/GOT2/DGAT2	0.0619101795789777
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1494	24/9376	1.04596162427488	EXT2/B3GAT3/NDST2/HS6ST3	0.0981502616363115
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1494	69/9376	1.0004850319151	CALM2/MAOA/MAOB/PPP1CB/CREB3L1/TH/PRKACB/PPP3CB/CALM3/ATF6B/GRIN2D	0.00176048660986633
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	40/1494	254/9376	0.988310196165238	CALM2/HTR2B/F2R/ERBB3/PDGFRA/SLC25A4/EDNRB/MYLK3/ITPKC/PLCE1/PHKG1/ATP2B3/CACNA1G/ATP2B4/NTRK1/PDGFC/KDR/CXCR4/PDGFD/PPIF/PRKACB/PDE1A/PPP3CB/RET/PHKA1/CALM3/ADCY7/PTGER3/P2RX4/GNA15/OXTR/MYLK/GRIN2D/HTR2A/AVPR1A/PLCD4/PDGFB/PLCB2/P2RX6/NOS3	-0.0822283866648678
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1494	31/9376	1.01222092671762	HSD17B14/UGDH/ALDH3A2/ALDH1B1/UGT2B7	0.0296714011807548
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1494	18/9376	1.04596162427488	ACACB/ACSL3/OXSM	0.0849733659848593
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1494	18/9376	1.04596162427488	CD320/MMADHC/MMAB	0.0849733659848593
NA	NA	hsa04382	Cornified envelope formation	34/1494	217/9376	0.983300328811405	KRT23/COL4A6/PKP2/CLDN20/S100A1/CLDN4/S100A6/ABHD5/KRT18/ELOVL1/SPTLC1/PPP2R1B/KRT81/CLDN23/S100A10/KRT8/ITGA6/S100A2/CLDN10/CLDN3/TJP1/KRT86/S100A13/TGM1/DST/CLDN5/KRT7/ELOVL4/KRT10/CLDN7/CLDN12/JUP/OCLN/PPP2R2B	-0.108356876910773
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	17/1494	109/9376	0.978789776844381	CCL3/CCL4/MAPK14/TOLLIP/IRF7/IFNAR2/STAT1/IRF9/PIK3CB/IL1B/CCL5/IFNAR1/IRAK4/PIK3CD/CD86/TLR2/CHUK	-0.0969687119715435
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	35/1494	224/9376	0.980589022757697	TGFBR1/B2M/IL1R2/ETS2/HLA-DMA/TSPO/SLC25A4/HLA-E/CDKN2C/IL2RB/TLN2/HLA-DPA1/HLA-DPB1/CREB3L1/KAT2B/HLA-DQA1/ANAPC16/TLN1/IL2RA/TBPL1/PIK3CB/ANAPC13/ANAPC10/HLA-A/PRKACB/LTBR/PPP3CB/CCND3/PIK3CD/ADCY7/CDC23/ATF6B/HLA-DMB/ANAPC15/CHUK	-0.128013604289263
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/1494	90/9376	0.976230849323219	RHEB/ADIPOR1/CREB3L1/EIF4E/SESN1/PIK3CB/PRKACB/PRKAG1/PIK3CD/ADCY7/ATF6B/PRKAB2/RPS6KB2/PRKAA2	-0.098642325095759
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/1494	90/9376	0.976230849323219	MAPK14/STAT1/CSNK2B/PIK3CB/ZAP70/PPP3CB/IFNGR1/PIK3CD/JAK2/TLR2/RPS6KB2/CHUK/IFNG/LAT	-0.098642325095759
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1494	45/9376	0.976230849323219	ABCB8/ABCA3/ABCC1/ABCA8/DEFB1/ABCA7/ABCA13	-0.0695822627629344
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/1494	71/9376	0.972302354959745	PDGFRA/SLC16A3/NTRK1/PIK3CB/TIGAR/G6PD/RET/PDK1/PGAM1/PIK3CD/PFKM	-0.101989755947416
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1494	12/9376	1.04596162427488	NCAM1/CD46	0.069358231406039
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	24/1494	155/9376	0.971732089648918	WNT6/WNT4/WNT5A/RAP1B/KCNA4/SCARB1/CDKN2C/WNT3/RAP1A/CACNA1G/CREB3L1/NCEH1/WNT10B/PRKACB/WNT9A/WNT16/ADCY7/ATF6B/AGT/WNT9B/WNT1/POMC/PLCB2/WNT3A	-0.15449458605514
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1494	52/9376	0.965503037792194	SCARB1/PRKACB/ADCY7/HSD17B7/ACOT2/HSD17B1/ACOT4/PLA2G4D	-0.108598571844904
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1494	39/9376	0.965503037792194	MTHFS/MTHFD2L/DHFR/MAT2B/BHMT2/SHMT1	-0.0939836264526607
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	7/1494	46/9376	0.955008439555323	PSMD3/PSMA2/PSMA1/PSMD6/PSMB3/ADRM1/IFNG	-0.133171677913366
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/1494	253/9376	0.967411146562535	SKP1/MYL12A/ARPC1B/RBX1/MYL9/MAPK14/TLN2/UBE2D1/PLCE1/ROCK2/UBE2V2/TIFA/CBX3/TLN1/RHOA/PIK3CB/HCLS1/C3/WASF2/IL1B/SEPTIN6/CCL5/IL18/PFN2/ARPC5/PIK3CD/UBE2N/FNBP1L/UBE2D4/ACTR3B/RPS6KB2/PFN4/CYTH4/MAP1LC3C/CHUK/PLCD4/RRAGD/PLCB2/NLRP3	-0.228772188049189
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	16/1494	105/9376	0.956307770765602	CCL4/CSNK2B/LTBR/IL1B/ZAP70/PARP1/GADD45G/IRAK4/BIRC3/CCL21/CHUK/TNFSF14/CCL13/LTB/TNFRSF11A/LAT	-0.19601002506825
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	22/1494	144/9376	0.958798155585304	WNT6/WNT4/WNT5A/MAPK14/WNT3/SMAD9/ID3/PIK3CB/WNT10B/ACVR1C/WNT9A/WNT16/IL6ST/PIK3CD/JAK2/TBX3/LEFTY2/WNT9B/WNT1/ID1/DLX5/WNT3A	-0.216916569552261
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/1494	157/9376	0.959353336914537	ARG1/SGK1/MFGE8/GULP1/MAPK14/VPS41/C1QB/BSG/ATP11A/ADAM9/SLC66A1/ITGB5/MERTK/VPS16/TYRO3/CPT1C/ODC1/PROS1/JAK2/RXRA/VPS33A/ANO4/SIRPA/PLA2G15	-0.223601925000355
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/1494	99/9376	0.950874203886252	ITGA1/SGCE/ITGA3/SGCB/ITGB5/ITGA6/CACNA2D3/PRKAG1/DES/PRKAB2/AGT/DAG1/ITGA4/SGCZ/PRKAA2	-0.21392726660315
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	21/1494	138/9376	0.955008439555323	CALM2/CPEB4/SKP1/PPP1CB/RBX1/MAPK14/RPS6KA2/PPP2R1B/YWHAE/ANAPC16/ANAPC13/ANAPC10/PRKACB/SPDYE2/PPP3CB/YWHAH/CALM3/ADCY7/CDC23/ANAPC15/RPS6KA1	-0.23180582336978
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1494	93/9376	0.944739531603115	CALM2/CAMP/BST1/VAMP2/ATP1B3/ATP2B3/ATP2B4/SLC4A2/CST2/PRKACB/CALM3/ADCY7/KCNMA1/PLCB2	-0.233160287669345
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/1494	80/9376	0.941365461847389	ERBB3/PDGFRA/NRG2/PDGFC/EIF4E/KDR/PDGFD/PIK3CB/PIK3CD/JAK2/RPS6KB2/PDGFB	-0.229294251187931
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	46/1494	300/9376	0.962284694332887	TGFBR1/RASGRP2/RAP1B/ERBB3/STMN1/PDGFRA/MAPK14/RPS6KA2/MAPK7/AREG/MRAS/MAP3K5/RAP1A/RAC2/CACNA1G/RRAS2/CSF1/NTRK1/PDGFC/MAP3K2/KDR/ANGPT2/PDGFD/CACNA2D3/IGF2/PRKACB/MAPKAPK3/IL1B/PPP5C/ANGPT1/PPP3CB/GADD45G/RET/MKNK1/ARRB2/IRAK4/PAK2/LAMTOR3/EPHA2/RPS6KA1/TEK/CHUK/PLA2G4D/RRAS/PTPN7/PDGFB	-0.289050508198626
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	20/1494	133/9376	0.943724773781844	CALM2/MAOA/MAOB/COMT/PPP1CB/MAPK14/PPP2R1B/CREB3L1/TH/GNB5/PRKACB/GNGT1/PPP3CB/KIF5C/CALM3/ARRB2/ATF6B/GNGT2/PLCB2/PPP2R2B	-0.284563579468809
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	23/1494	154/9376	0.937290286687877	CALM2/PPP1CB/MYL9/MYLK3/MAPK7/ROCK2/RHOA/CACNA2D3/PRKACB/PPP3CB/PRKAG1/CALM3/ADCY7/NPR1/PRKAB2/OXTR/MYLK/PLA2G4D/OXT/PLCB2/TRPM2/PRKAA2/NOS3	-0.34160588076173
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/1494	82/9376	0.9184053286316	UPP1/CDA/MGST1/MGST2/CMPK1/RRM1/GSTA1/GSTT2B/NME1/HPRT1/CYP2A6/UGT2B7	-0.323080027656859
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1494	62/9376	0.910998834045861	LFNG/MAML3/NCSTN/APH1B/PSENEN/TLE6/KAT2B/PSEN2/HEYL	-0.306101984894396
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	25/1494	168/9376	0.933894307388283	GLUL/SLC25A4/STAT4/CHMP5/FTH1/IFNAR2/STAT1/IRF9/FTL/IL1B/PARP1/CHMP2A/SMPD1/EIF2AK2/IFNGR1/PYGL/IFNAR1/JAK2/BIRC3/PLA2G4D/ZBP1/PYGM/CHMP4C/IFNG/NLRP3	-0.376403425456276
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	34/1494	227/9376	0.939983133709581	CALM2/B2M/RHEB/CCL3/CCL4/PDGFRA/HLA-E/MAPK14/RAC2/ROCK2/CCL2/CREB3L1/CXCR4/RHOA/PIK3CB/GNB5/HLA-A/PRKACB/GNGT1/IL1B/CCL5/PPP3CB/TAPBP/CALM3/PIK3CD/ADCY7/ATF6B/PTGER3/IL10RB/RPS6KB2/CHUK/TAPBPL/GNGT2/PLCB2	-0.398512686895261
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/1494	76/9376	0.908335094765025	CALM2/MYLK3/EZR/ATP1B3/SLC4A2/PRKACB/CALM3/ADCY7/MYLK/PLCB2/CA2	-0.3493100953851
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	17/1494	116/9376	0.919724876517564	HOMER2/SLC1A1/SLC1A2/GLUL/GRK3/SLC38A1/GRM7/GNB5/PRKACB/GNGT1/PPP3CB/ADCY7/SLC1A3/GRIN2D/PLA2G4D/GNGT2/PLCB2	-0.378745259032165
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/1494	56/9376	0.896538535092752	SAR1A/SAR1B/SEC22B/RAB1A/C3/IL1B/IL18/TLR2	-0.338070598358766
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	15/1494	103/9376	0.913947050337271	COL14A1/COL4A6/SLC1A1/CPA1/CPB1/MME/PRCP/COL24A1/SLC7A8/ATP1B3/KCNE3/COL26A1/SLC16A10/SLC3A2/SLC7A7	-0.38231115106803
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/1494	130/9376	0.917227885902585	TGFBR1/COL4A6/MMP9/RXFP1/EDNRB/MAPK14/CREB3L1/PIK3CB/GNB5/PRKACB/GNGT1/ARRB2/PIK3CD/ADCY7/ATF6B/GNA15/GNGT2/PLCB2/NOS3	-0.413734275338465
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/1494	70/9376	0.896538535092752	RAP1B/RBX1/EPAS1/RAP1A/ELOB/PIK3CB/EGLN2/PAK2/PIK3CD/PDGFB	-0.378258626158685
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/1494	29/9376	0.865623413193002	CALM2/GNGT1/CALM3/RCVRN	-0.315521679512494
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/1494	77/9376	0.896538535092752	TGFBR1/RAC2/RALBP1/STAT1/RALA/PIK3CB/GADD45G/PIK3CD/RPS6KB2/CHUK/DDB2	-0.396870285577454
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	25/1494	170/9376	0.922907315536656	WNT6/TGFBR1/WNT4/WNT5A/MGST1/SMARCB1/MGST2/WNT3/GSTA1/TXNRD2/PIK3CB/WNT10B/GSTT2B/IGF2/WNT9A/WNT16/GADD45G/TXNRD3/PIK3CD/BRD7/WNT9B/WNT1/RPS6KB2/DDB2/WNT3A	-0.44161606706283
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	23/1494	157/9376	0.919380281209765	TGFBR1/CALM2/RHEB/IGFBP3/PPP1CB/SLC25A4/HLA-E/SERPINE1/MAPK14/MRAS/HIPK2/RRAS2/NBN/KIR2DL4/RBBP4/PIK3CB/HLA-A/PPP3CB/GADD45G/CCND3/CALM3/PIK3CD/RRAS	-0.443498259047274
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/1494	71/9376	0.883911231781586	PRL/PRLR/MAPK14/CISH/STAT1/TH/PIK3CB/PIK3CD/JAK2/TNFRSF11A	-0.427468296370485
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	23/1494	158/9376	0.913561418670462	SKP1/CDKN1C/RBX1/CDKN2C/TRIP13/PPP2R1B/ORC3/CCNH/YWHAE/ANAPC16/ANAPC13/ANAPC10/YWHAH/GADD45G/CCND3/ORC6/CDC23/ANAPC15/MTBP/MAD2L1BP/CDC45/MCM5/MCM2	-0.477046313070752
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/1494	78/9376	0.885044451309511	CALM2/SERPING1/MAPK14/C1QB/CFL2/RHOA/C3/IL1B/CALM3/IRAK4/NLRP3	-0.443838723959684
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/1494	44/9376	0.855786783497627	GTF2H5/MNAT1/CCNH/TBPL1/GTF2A2/TAF6	-0.417432979974074
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/1494	106/9376	0.88808062438433	MMP9/IL1R2/KLK3/PDGFRA/CREB3L1/PDGFC/HSP90B1/PDGFD/PIK3CB/SLC46A1/PIK3CD/FOLR1/CHUK/PDGFB/SPINT1	-0.504499878348577
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1494	23/9376	0.818578662475991	ZMPSTE24/GGPS1/RCE1	-0.379244714654997
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/1494	133/9376	0.896538535092752	TGFBR1/DEPP1/HOMER2/SGK1/GABARAPL2/GABARAP/KLF2/MAPK14/CCNG2/G6PC3/SETD7/PIK3CB/GADD45G/PRKAG1/PIK3CD/PRKAB2/CHUK/S1PR4/PRKAA2	-0.523167417878713
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	33/1494	226/9376	0.916373458435512	CALM2/RAP1B/PPP1CB/F2R/FXYD1/MYL9/PLCE1/RAP1A/RAC2/PDE4B/ROCK2/VAV3/AFDN/VIPR2/ATP1B3/ATP2B3/RRAS2/CREB3L1/ATP2B4/RHOA/PIK3CB/PRKACB/CALM3/PIK3CD/ADCY7/NPR1/PTGER3/OXTR/GRIN2D/OXT/ARAP3/RRAS/POMC	-0.554026490517131
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1494	31/9376	0.809776741374098	SMOX/ACADS/ALDH3A2/ALDH1B1	-0.461846368202208
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1494	53/9376	0.828875249425374	CLTB/ATP1B3/ATP2B3/ATP2B4/PRKACB/AP2S1/PLCB2	-0.543895721499334
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	17/1494	122/9376	0.874492505541291	PTPRC/NCK1/MAPK14/ITK/VAV3/PPP2R1B/RHOA/PIK3CB/ZAP70/PPP3CB/PAK2/PIK3CD/TEC1/CHUK/IFNG/LAT/PPP2R2B	-0.607473796294426
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/1494	102/9376	0.861380161167546	CPA1/RAP1B/BST1/CPB1/RAP1A/ATP1B3/ATP2B3/ATP2B4/RHOA/SLC4A2/ADCY7/KCNMA1/PLCB2/CA2	-0.612822428253228
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9/1494	68/9376	0.830616583982991	CYP3A5/DHRS3/DHRS9/HSD17B6/CYP26B1/DGAT1/RETSAT/CYP2A6/UGT2B7	-0.610295092765603
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1494	17/9376	0.738325852429325	GGT5/CDO1	-0.470124924636566
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/1494	110/9376	0.855786783497627	CPEB4/MAPK14/RPS6KA2/ANAPC16/PIK3CB/ANAPC13/ANAPC10/PRKACB/SPDYE2/KIF22/PIK3CD/ADCY7/CDC23/ANAPC15/RPS6KA1	-0.662365920956573
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/1494	83/9376	0.831728520507734	SKP1/UBE2D1/CBX3/E2F6/CSNK2B/RBBP4/EED/CBX4/USP16/UBE2D4/CBX8	-0.670369601307808
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/1494	69/9376	0.818578662475991	FCER1G/MAPK14/RAC2/VAV3/MS4A2/PIK3CB/PIK3CD/PLA2G4D/LAT	-0.658492411554362
NA	NA	hsa04081	Hormone signaling	31/1494	219/9376	0.888350968562225	PRL/SLC40A1/PRLR/ADIPOR1/SMAD9/NPR3/VIPR2/RAMP1/SLC16A10/LEPR/RHOA/PIK3CB/GNB5/IGF2/PRKACB/GNGT1/PIK3CD/ADCY7/JAK2/NPR1/AGT/GNA15/OXTR/GHR/RAMP3/AVPR1A/OXT/PENK/GNGT2/POMC/PLCB2	-0.72785208747252
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	19/1494	139/9376	0.857839029980835	KRT23/CTSD/CALM2/MMP9/KRT18/CREB3L1/HSP90B1/FKBP5/PIK3CB/PRKACB/EBAG9/CALM3/PIK3CD/ADCY7/ATF6B/KRT10/POMC/PLCB2/NOS3	-0.735131492750266
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/1494	91/9376	0.827574032393309	CD81/LILRB3/CD79B/RAC2/VAV3/PIK3CB/PIK3AP1/PPP3CB/PIK3CD/CHUK/CD22/BANK1	-0.719573457851022
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1494	41/9376	0.765337773859666	BABAM2/NBN/RAD51C/POLD4/BLM	-0.655572421124623
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/1494	105/9376	0.836769299419902	ITGA1/SGCE/ITGA3/SGCB/ITGB5/ITGA6/CACNA2D3/PRKACB/DES/ADCY7/AGT/DAG1/ITGA4/SGCZ	-0.732277896395918
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	9/1494	70/9376	0.806884681583477	CYP3A5/HSD11B1/MGST1/MGST2/GSTA1/SULT1A1/GSTT2B/CYP2A6/UGT2B7	-0.706036156552755
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	27/1494	196/9376	0.864519301696582	CALM2/HLA-E/MAPK14/IRF7/IFNAR2/STAT1/IRF9/ANGPT2/PIK3CB/GNB5/HLA-A/C3/GNGT1/PPP3CB/PREX1/EIF2AK2/CALM3/IFNGR1/IFNAR1/IL6ST/PIK3CD/JAK2/CD86/MAP1LC3C/CHUK/GNGT2/PDGFB	-0.834500964951384
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/1494	115/9376	0.818578662475991	SGK1/WNK3/PDE4B/CREB3L1/MMP14/RHOA/MEF2A/PRKACB/ARRB2/ADCY7/ATF6B/BGLAP/RXRA/WNK2/PLCB2	-0.852218709068738
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	16/1494	122/9376	0.823051769921215	WNT4/RHEB/TBC1D4/PLCE1/ATP1B3/STAT1/KAT2B/SLC16A10/PIK3CB/PRKACB/PIK3CD/PFKM/RXRA/RCAN2/PLCD4/PLCB2	-0.856454138751872
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/1494	73/9376	0.773725037134841	MAOA/MAOB/CYP3A5/MGST1/MGST2/GSTA1/GSTT2B/CYP2A6/UGT2B7	-0.844946368132823
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1494	36/9376	0.697307749516585	AKR1B1/DCXR/UGDH/UGT2B7	-0.792176283635239
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/1494	103/9376	0.792087443625635	ARG1/COL4A6/IL1R2/LAMC3/PIK3CB/PRKACB/CD1D/IL1B/PIK3CD/TLR2/GNA15/IFNG/PLCB2	-0.92370208180566
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/1494	89/9376	0.775656934855527	ITGA1/VTN/COL4A6/ITGA3/LAMC3/SDC1/ITGB5/ITGA6/DAG1/ITGA4/FREM1	-0.925790353987422
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	9/1494	75/9376	0.753092369477912	MGST1/MGST2/MAP3K5/GSTA1/PIK3CB/GSTT2B/PIK3CD/BIRC3/ATP7B	-0.934637157590301
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/1494	75/9376	0.753092369477912	GPX3/ATP1B3/CREB3L1/GPX8/HSP90B1/PRKACB/ADCY7/ATF6B/PLCB2	-0.934637157590301
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	12/1494	97/9376	0.776383886059703	CALM2/NOS1AP/CACNA1G/GNB5/PER3/PRKACB/GNGT1/CALM3/ADCY7/GRIN2D/GNGT2/PLCB2	-0.963787073951922
Organismal Systems	Digestive system	hsa04976	Bile secretion	11/1494	90/9376	0.767038524468243	SCARB1/ATP1B3/NCEH1/SLC4A2/PRKACB/SLC22A1/ADCY7/AQP1/RXRA/CA2/UGT2B7	-0.96679355172076
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/1494	38/9376	0.660607341647291	SGK1/ATP1B3/PIK3CB/PIK3CD	-0.912662126726031
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/1494	91/9376	0.758609529693867	GRK3/PDE4B/GRK5/GNB5/PRKACB/GNGT1/PDE1A/ARRB2/ADCY7/GABRB3/GNGT2	-1.00737828426563
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/1494	78/9376	0.724127278344146	DHX36/NUDT16/PARN/LSM4/C1D/CNOT7/EXOSC4/PFKM/EXOSC9	-1.06513342026395
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/1494	93/9376	0.74229534625959	COL4A6/ITGA3/LAMC3/ITGA6/PIK3CB/GADD45G/PIK3CD/BIRC3/RXRA/CHUK/DDB2	-1.08733228188181
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1494	13/9376	0.482751518896097	LIG4	-0.812467710740685
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	18/1494	144/9376	0.784471218206158	MAPK14/ADIPOR1/C1QB/MAP3K5/ACACB/C3/IL1B/CPT1C/PRKAG1/LPIN2/IRAK4/PRKAB2/ALDH3A2/ACADM/ALDH1B1/CHUK/NOX4/PRKAA2	-1.13470075552789
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/1494	86/9376	0.729740668098752	KCNMB4/VAMP2/ATP1B3/CREB3L1/PRKACB/ADCY7/ATF6B/KCNMA1/TRPM4/PLCB2	-1.0961368777396
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1494	48/9376	0.653726015171798	ATP1B3/G6PC3/PIK3CB/PIK3CD/PLCB2	-1.04710187286362
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/1494	87/9376	0.721352844327502	TGFBR1/AREG/RAC2/RALA/RHOA/PIK3CB/GADD45G/PIK3CD/RPS6KB2/DDB2	-1.13676967816846
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/1494	73/9376	0.687755588564303	PDGFRA/PDGFC/PDGFD/PIK3CB/GADD45G/PIK3CD/DDB2/PDGFB	-1.16596983630745
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/1494	89/9376	0.705142668050479	GABARAPL2/GLUL/GABARAP/SLC38A1/GNB5/PRKACB/GNGT1/ADCY7/GABRB3/GNGT2	-1.21677963856624
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	27/1494	214/9376	0.791802724918365	CALM2/B2M/SKP1/BST2/HLA-E/RBX1/MAPK14/CFL2/RAC2/ELOB/SAMHD1/CXCR4/PIK3CB/GNB5/HLA-A/GNGT1/PPP3CB/TAPBP/CALM3/IRAK4/PAK2/PIK3CD/TLR2/RPS6KB2/CHUK/TAPBPL/GNGT2	-1.34131106024244
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	18/1494	150/9376	0.753092369477912	WNT6/TGFBR1/WNT4/WNT5A/WNT3/PIK3CB/WNT10B/WNT9A/WNT16/GADD45G/PIK3CD/WNT9B/WNT1/RPS6KB2/RXRA/DDB2/JUP/WNT3A	-1.32713816279831
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/1494	76/9376	0.660607341647291	CALM2/PDGFRA/PIK3CB/GADD45G/CALM3/PIK3CD/DDB2/PDGFB	-1.29333338160648
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1494	115/9376	0.709434840812526	MAOA/MAOB/HTR2B/KCND2/ALOX15B/GNB5/PRKACB/GNGT1/GABRB3/PLA2G4D/HTR2A/GNGT2/PLCB2	-1.36491698409142
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/1494	93/9376	0.674813951145082	CALM2/MAPK14/MAPK7/MAP3K2/MMP14/PRKACB/CALM3/ADCY7/PLA2G4D/PLCB2	-1.37205627995264
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/1494	86/9376	0.656766601288876	ERBB3/NCK1/AREG/NRG2/PIK3CB/CBL/PAK2/PIK3CD/RPS6KB2	-1.39211024963473
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/1494	54/9376	0.581089791263821	ATRIP/RAD51C/FANCB/FAAP24/BLM	-1.34402082022486
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/1494	79/9376	0.635520986901191	CYP3A5/HSD11B1/MGST1/MGST2/GSTA1/GSTT2B/CYP2A6/UGT2B7	-1.4163069239283
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/1494	63/9376	0.597692356728501	PLOD1/SETD7/DHTKD1/ALDH3A2/SUV39H1/ALDH1B1	-1.3948466976142
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/1494	103/9376	0.670227836913999	PPP1CB/PELO/PPP2R1B/RBM8A/GSPT2/MSI2/CPSF2/UPF1/NXT2/CSTF2/PPP2R2B	-1.46509301254329
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/1494	72/9376	0.610144280827012	ISG15/PIN1/MAPK14/IFIH1/IRF7/CHUK/DHX58	-1.44569949302071
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1494	38/9376	0.495455506235468	PTPRC/UNG/ZAP70	-1.35677257410943
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/1494	56/9376	0.56033658443297	GRK3/GAS1/PRKACB/ARRB2/CDON	-1.43664381816415
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/1494	73/9376	0.601786139993765	PIK3CB/KIF5C/GADD45G/RET/PIK3CD/RXRA/DDB2	-1.48699330448207
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	24/1494	205/9376	0.73472426290528	HDAC9/HLA-E/CREB3L1/IRF7/KAT2B/YWHAE/IRF9/TBPL1/RHOA/PIK3CB/HLA-A/PRKACB/LTBR/C3/YWHAH/GTF2A2/EIF2AK2/CCND3/IL6ST/PIK3CD/HDAC11/ATF6B/SCIN/ATP6V0D2	-1.67189437038143
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/1494	115/9376	0.654862929980793	KCNQ5/CREB3L1/PIK3CB/GNB5/PRKACB/GNGT1/PIK3CD/ADCY7/JAK2/GNGT2/PLCB2/CHRNA6	-1.62126612160276
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1494	41/9376	0.4592026643158	GABRB3/GRIN2D/CHRNA6	-1.51081758885309
Genetic Information Processing	Translation	hsa03010	Ribosome	26/1494	222/9376	0.735000060301265	MRPL33/MRPS6/MRPS18A/MRPL54/MRPL52/MRPL53/MRPL38/MRPL34/MRPS2/MRPL20/MRPL42/MRPS28/MRPS23/MRPL37/MRPL47/RPL36AL/MRPL32/MRPS16/MRPS34/MRPS25/MRPL46/MRPL48/MRPS18C/MRPS33/MRPL55/MRPL35	-1.73964058086764
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	18/1494	163/9376	0.693029787863109	TGFBR1/MMP9/STAT4/MAPK14/ATP6AP1/IFIH1/CREB3L1/IRF7/STAT1/PIK3CB/IFNAR1/IRAK4/PIK3CD/JAK2/TLR2/ATF6B/CHUK/DDB2	-1.72120350829492
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/1494	148/9376	0.678461594124245	WNT6/WNT4/WNT5A/WNT3/PIK3CB/WNT10B/WNT9A/WNT16/GADD45G/PIK3CD/WNT9B/WNT1/RPS6KB2/HEYL/DDB2/WNT3A	-1.71653491168083
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/1494	77/9376	0.570524522331751	TGFBR1/PIK3CB/GADD45G/CBL/PIK3CD/CHUK/DDB2	-1.64743516461433
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/1494	201/9376	0.718122906218573	MMP9/IL1R2/IGFBP3/GZMB/CDKN2C/IL2RB/NR4A3/HOXA9/NTRK1/NUPR1/WNT16/GADD45G/SIX4/CD86/BIRC3/TSPAN7/CDK9/RXRA/MYCN/SLC45A3/DDB2/SPINT1/JUP	-1.75872322641228
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	15/1494	144/9376	0.653726015171798	SLC25A4/MAP3K5/PSMD3/TBPL1/PPIF/PSMA2/PIK3CB/PSMA1/PSMD6/PIK3CD/ATG2B/PSMB3/ADRM1/GRIN2D/PLCB2	-1.82303889500961
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1494	63/9376	0.498076963940418	GGT5/GPX4/ALOX15B/LTA4H/PLA2G4D	-1.74022467883299
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/1494	122/9376	0.617288827440911	IGFBP3/MAPK14/CREB3L1/STAT1/PIK3CB/PRKACB/PIK3CD/ADCY7/JAK2/ATF6B/GHR/PLCB2	-1.85237550858166
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1494	23/9376	0.272859554158664	POLD4	-1.52002060320336
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	16/1494	154/9376	0.652028025522001	CALM2/PPP1CB/MAPK14/PPP2R1B/ATP1B3/ATP2B3/CREB3L1/ATP2B4/CACNA2D3/PRKACB/CALM3/ADCY7/ATF6B/AGT/PLCB2/PPP2R2B	-1.89554801869865
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/1494	65/9376	0.482751518896097	CACNA1G/PIK3CB/ARRB2/PIK3CD/PLCB2	-1.82179900569624
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/1494	108/9376	0.581089791263821	TMEM33/RANGAP1/RANBP2/AHCTF1/RBM8A/UPF1/NUP210/AAAS/CSE1L/NXT2	-1.90626173837347
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/1494	47/9376	0.400581047594634	CACNA1G/PIK3CB/PIK3CD	-1.79351318789495
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/1494	94/9376	0.534108063459512	MMP9/MAPK14/MAPK7/CCL2/HSP90B1/IL1B/CHUK/IFNG	-1.97638277584559
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/1494	68/9376	0.461453657768328	PIK3CB/PIK3CD/RPS6KB2/CHUK/JUP	-1.94040359805856
NA	NA	hsa04082	Neuroactive ligand signaling	21/1494	199/9376	0.662267159088616	SLC1A1/SLC1A2/HTR2B/GRM7/GNB5/PRKACB/GNGT1/ADCY7/GLRB/GABRB3/P2RX4/SLC1A3/GRIN2D/HTR2A/PENK/GNGT2/POMC/PLCB2/P2RY14/P2RX6/CHRNA6	-2.09648706498816
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1494	26/9376	0.241375759448049	PLA2G4D	-1.68636005299813
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/1494	59/9376	0.425475914959272	PIK3CB/GADD45G/PIK3CD/DDB2	-1.9272538394117
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/1494	99/9376	0.507132908739334	MMP9/CDKN2C/MAPK14/PIK3CB/PRKACB/PIK3CD/ADCY7/RPS6KB2	-2.14627991753873
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/1494	29/9376	0.21640585329825	WWC1	-1.83991085871679
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	25/1494	238/9376	0.659219511097612	ISG15/MAPK14/MX1/C1QB/CCL2/IFIH1/MASP1/IFNAR2/STAT1/IRF9/PIK3CB/C3/IL1B/RPL36AL/EIF2AK2/OAS3/IFNAR1/IRAK4/IL6ST/PIK3CD/FGG/TLR2/OAS2/CHUK/NLRP3	-2.31835717036424
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1494	30/9376	0.209192324854975	PLA2G4D	-1.88869285068289
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/1494	32/9376	0.196117804551539	BIRC3	-1.98309585082697
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	17/1494	183/9376	0.582995003694194	MDN1/REXO2/POP4/RRP7A/TCOF1/GNL2/SNU13/SBDS/AK6/CSNK2B/NOP10/RCL1/RPP25/EFL1/RPP30/POP7/NXT2	-2.48016683023557
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	41/1494	370/9376	0.695423133977351	PRL/PRLR/PGRMC2/CNR1/GAL/ADM/HTR2B/RXFP1/F2R/TSPO/EDNRB/LYNX1/LYPD6/LPAR1/VIPR2/LEPR/PTGIR/GRM7/C3/PGRMC1/GLRB/GABRB3/PTGER3/P2RX4/AGT/OXTR/GHR/GRIN2D/HTR2A/AVPR1A/OXT/PENK/LPAR3/TMEM97/PTGDR/KNG1/POMC/S1PR4/P2RY14/P2RX6/CHRNA6	-2.60240285088736
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	21/1494	217/9376	0.607332556030574	MGST1/RPS6KA2/MGST2/CREB3L1/PAQR7/GSTA1/HSP90B1/PIK3CB/GSTT2B/PRKACB/CCND3/ARRB2/PIK3CD/ADCY7/JAK2/ATF6B/WNT1/RPS6KB2/RXRA/RPS6KA1/UGT2B7	-2.54784764397769
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/1494	60/9376	0.313788487282463	PPP2R1B/PLA2G4D/PLCB2	-2.32146214898574
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/1494	195/9376	0.579301822675317	CAMP/CYBA/HDAC9/SLC25A4/MAPK14/RAC2/SELPLG/PPIF/PIK3CB/C3/CLCN3/PIK3CD/HDAC11/FGG/TLR2/SIGLEC9/NCF4/PLCB2	-2.58455431918022
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	8/1494	117/9376	0.429112461240975	SMARCB1/TFPT/RBBP4/BAZ1A/MEAF6/BRD7/INO80C/CECR2	-2.7052298689064
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/1494	41/9376	0.153067554771933	MMP9	-2.36606275658155
Human Diseases	Substance dependence	hsa05034	Alcoholism	16/1494	191/9376	0.525718931572713	CALM2/MAOA/MAOB/SLC29A1/PPP1CB/HDAC9/CREB3L1/TH/GNB5/PRKACB/GNGT1/CALM3/HDAC11/ATF6B/GRIN2D/GNGT2	-2.88307283781373
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/1494	143/9376	0.43886501717827	HLA-DMA/C1QB/HLA-DPA1/HLA-DPB1/HLA-DQA1/SNRPD3/C3/CD86/HLA-DMB/IFNG	-2.94378892704749
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1494	86/9376	0.218922200429625	PRKACB/PDE1A/PLCB2	-3.16795048100551
Genetic Information Processing	Transcription	hsa03040	Spliceosome	17/1494	243/9376	0.439045620065998	SNRPG/LSM4/RP9/SNU13/SNRPD3/SNRNP27/BCAS2/RBM8A/TXNL4A/CDC40/PRPF6/DHX16/CRNKL1/SF3B6/ZMAT2/PPIL1/YJU2	-3.85715128426431
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	16/1494	323/9376	0.310874043128137	MMP9/ERBB3/STMN1/PDGFRA/FOXP1/WNT3/MAPK7/EZR/DICER1/RHOA/PIK3CB/ABCC1/PIK3CD/SLC45A3/PDGFB/WNT3A	-5.48714366604491
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1494	449/9376	0.0978405082840643	CALM2/GRK3/NCALD/PRKACB/PDE1A/CALM3/ARRB2	-8.52896726462246