ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0022853 active monoatomic ion transmembrane transporter activity 53/2997 118/18639 0.449152542372881 2.7933781238866 1.31915387564263e-13 1.76107042398291e-10 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 35/2997 68/18639 0.514705882352941 3.2010687157746 1.52172197110757e-11 1.0157494157143e-08 GO:0015399 primary active transmembrane transporter activity 61/2997 166/18639 0.367469879518072 2.28537573718297 7.40682653806603e-11 3.29603780943938e-08 GO:0009055 electron transfer activity 47/2997 116/18639 0.405172413793103 2.51985606295951 2.48371266179697e-10 8.2893910087474e-08 GO:0015078 proton transmembrane transporter activity 63/2997 185/18639 0.340540540540541 2.11789627465303 1.34433043856845e-09 3.58936227097776e-07 GO:0008137 NADH dehydrogenase (ubiquinone) activity 23/2997 41/18639 0.560975609756098 3.48883029370834 5.28756196934396e-09 1.17648253817903e-06 GO:0003954 NADH dehydrogenase activity 23/2997 44/18639 0.522727272727273 3.2509555009555 3.20840665159599e-08 6.11888982840092e-06 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 26/2997 58/18639 0.448275862068966 2.78792585689137 2.28217709112012e-07 3.80838302080671e-05 GO:0016651 oxidoreductase activity, acting on NAD(P)H 33/2997 88/18639 0.375 2.33220720720721 9.39067371557103e-07 0.000130047550088088 GO:0022804 active transmembrane transporter activity 113/2997 457/18639 0.2472647702407 1.53779381131679 9.74138951970698e-07 0.000130047550088088 GO:0042625 ATPase-coupled ion transmembrane transporter activity 13/2997 24/18639 0.541666666666667 3.36874374374374 2.01154235005123e-05 0.00206569925947568 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 13/2997 24/18639 0.541666666666667 3.36874374374374 2.01154235005123e-05 0.00206569925947568 GO:0046961 proton-transporting ATPase activity, rotational mechanism 13/2997 24/18639 0.541666666666667 3.36874374374374 2.01154235005123e-05 0.00206569925947568 GO:0019706 protein-cysteine S-palmitoyltransferase activity 13/2997 25/18639 0.52 3.23399399399399 3.57376563401895e-05 0.00318065141427687 GO:0019707 protein-cysteine S-acyltransferase activity 13/2997 25/18639 0.52 3.23399399399399 3.57376563401895e-05 0.00318065141427687 GO:0016417 S-acyltransferase activity 14/2997 29/18639 0.482758620689655 3.00238169203686 5.22315084175125e-05 0.0043580664835862 GO:0004129 cytochrome-c oxidase activity 9/2997 15/18639 0.6 3.73153153153153 0.000140302082964242 0.0110178400445449 GO:0016409 palmitoyltransferase activity 15/2997 36/18639 0.416666666666667 2.59134134134134 0.000226610823616725 0.0168069694182404 GO:0016675 oxidoreductase activity, acting on a heme group of donors 9/2997 16/18639 0.5625 3.49831081081081 0.000274889810509073 0.0193146261594533 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 19/2997 54/18639 0.351851851851852 2.18824379935491 0.000478384598629887 0.031932171958545 GO:0051537 2 iron, 2 sulfur cluster binding 12/2997 28/18639 0.428571428571429 2.66537966537967 0.00070447728795684 0.044784627591542 GO:0048531 beta-1,3-galactosyltransferase activity 8/2997 15/18639 0.533333333333333 3.31691691691692 0.000978897545592185 0.0594012828802531 GO:0023023 MHC protein complex binding 14/2997 37/18639 0.378378378378378 2.35321808294781 0.00115247406720977 0.0668936034663065 GO:0015485 cholesterol binding 18/2997 54/18639 0.333333333333333 2.07307307307307 0.00137407879934703 0.0733758078851317 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 18/2997 54/18639 0.333333333333333 2.07307307307307 0.00137407879934703 0.0733758078851317 GO:0032934 sterol binding 21/2997 68/18639 0.308823529411765 1.92064122946476 0.00172112835865965 0.0883733214927166 GO:0004896 cytokine receptor activity 27/2997 96/18639 0.28125 1.74915540540541 0.00196915071814824 0.0940452186864811 GO:0019955 cytokine binding 37/2997 144/18639 0.256944444444444 1.59799382716049 0.00202167332364987 0.0940452186864811 GO:0070325 lipoprotein particle receptor binding 12/2997 31/18639 0.387096774193548 2.40743969776228 0.00204292984412581 0.0940452186864811 GO:0052689 carboxylic ester hydrolase activity 26/2997 92/18639 0.282608695652174 1.75760543151847 0.00219348478272199 0.0976100728311286 GO:0016757 glycosyltransferase activity 61/2997 267/18639 0.228464419475655 1.42087030851076 0.0023324901897161 0.100447561395838 GO:0051117 ATPase binding 24/2997 84/18639 0.285714285714286 1.77691977691978 0.0027164283978581 0.110308026481567 GO:0015036 disulfide oxidoreductase activity 14/2997 40/18639 0.35 2.17672672672673 0.0027267152613421 0.110308026481567 GO:0030246 carbohydrate binding 63/2997 280/18639 0.225 1.39932432432432 0.00292890480137453 0.115002585583382 GO:0046915 transition metal ion transmembrane transporter activity 15/2997 45/18639 0.333333333333333 2.07307307307307 0.0033558873816194 0.128003132984626 GO:0005518 collagen binding 21/2997 72/18639 0.291666666666667 1.81393893893894 0.00371829699000079 0.135267824559759 GO:0051861 glycolipid binding 11/2997 29/18639 0.379310344827586 2.35901418660039 0.00374899588667496 0.135267824559759 GO:0005109 frizzled binding 13/2997 38/18639 0.342105263157895 2.12762762762763 0.00478267592481206 0.1677898654985 GO:0015035 protein-disulfide reductase activity 12/2997 34/18639 0.352941176470588 2.19501854795972 0.00497396483510687 0.1677898654985 GO:0050750 low-density lipoprotein particle receptor binding 10/2997 26/18639 0.384615384615385 2.39200739200739 0.0050274117003296 0.1677898654985 GO:0042626 ATPase-coupled transmembrane transporter activity 26/2997 98/18639 0.26530612244898 1.64999693571122 0.00557540218970876 0.181540534713688 GO:0008375 acetylglucosaminyltransferase activity 14/2997 43/18639 0.325581395348837 2.0248620713737 0.00574510863768659 0.182612381697895 GO:0016829 lyase activity 46/2997 200/18639 0.23 1.43042042042042 0.00655174624422778 0.195668588898227 GO:0004300 enoyl-CoA hydratase activity 6/2997 12/18639 0.5 3.10960960960961 0.0065955704122998 0.195668588898227 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 6/2997 12/18639 0.5 3.10960960960961 0.0065955704122998 0.195668588898227 GO:0023026 MHC class II protein complex binding 10/2997 27/18639 0.37037037037037 2.30341452563675 0.00685168708721465 0.198847875248512 GO:0016790 thiolester hydrolase activity 14/2997 44/18639 0.318181818181818 1.97884247884248 0.00720312290308866 0.20459934203454 GO:0050840 extracellular matrix binding 19/2997 67/18639 0.283582089552239 1.76365918156963 0.00780954867115235 0.217203072416425 GO:0008009 chemokine activity 14/2997 45/18639 0.311111111111111 1.93486820153487 0.0089405841063328 0.238021862327839 GO:0045499 chemorepellent activity 10/2997 28/18639 0.357142857142857 2.22114972114972 0.00914893909560271 0.238021862327839 GO:0030215 semaphorin receptor binding 9/2997 24/18639 0.375 2.33220720720721 0.00927126355134654 0.238021862327839 GO:0060229 lipase activator activity 9/2997 24/18639 0.375 2.33220720720721 0.00927126355134654 0.238021862327839 GO:0005338 nucleotide-sugar transmembrane transporter activity 6/2997 13/18639 0.461538461538462 2.87040887040887 0.0105992325159236 0.266980668089773 GO:0005496 steroid binding 27/2997 108/18639 0.25 1.5548048048048 0.0110518250754338 0.273225675476003 GO:0016830 carbon-carbon lyase activity 15/2997 51/18639 0.294117647058824 1.82918212329977 0.012061446070588 0.277875434431872 GO:0005092 GDP-dissociation inhibitor activity 7/2997 17/18639 0.411764705882353 2.56085497261968 0.0120724907843061 0.277875434431872 GO:0032977 membrane insertase activity 7/2997 17/18639 0.411764705882353 2.56085497261968 0.0120724907843061 0.277875434431872 GO:0048038 quinone binding 7/2997 17/18639 0.411764705882353 2.56085497261968 0.0120724907843061 0.277875434431872 GO:0120020 cholesterol transfer activity 9/2997 25/18639 0.36 2.23891891891892 0.0124576331269792 0.281880342788428 GO:0016758 hexosyltransferase activity 44/2997 197/18639 0.223350253807107 1.38906419109465 0.0129756937927477 0.287456008899159 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 50/2997 229/18639 0.218340611353712 1.35790812646708 0.013134694039587 0.287456008899159 GO:0016836 hydro-lyase activity 17/2997 61/18639 0.278688524590164 1.733225028307 0.0137191614337167 0.2926582824214 GO:0005178 integrin binding 37/2997 161/18639 0.229813664596273 1.42926155969634 0.0138108402940436 0.2926582824214 GO:0140375 immune receptor activity 36/2997 156/18639 0.230769230769231 1.43520443520444 0.0140742514159917 0.293580088130451 GO:0001965 G-protein alpha-subunit binding 10/2997 30/18639 0.333333333333333 2.07307307307307 0.0154505807316814 0.310734695576349 GO:0016769 transferase activity, transferring nitrogenous groups 10/2997 30/18639 0.333333333333333 2.07307307307307 0.0154505807316814 0.310734695576349 GO:0008474 palmitoyl-(protein) hydrolase activity 6/2997 14/18639 0.428571428571429 2.66537966537967 0.0160604449399012 0.310734695576349 GO:0032036 myosin heavy chain binding 6/2997 14/18639 0.428571428571429 2.66537966537967 0.0160604449399012 0.310734695576349 GO:0098599 palmitoyl hydrolase activity 6/2997 14/18639 0.428571428571429 2.66537966537967 0.0160604449399012 0.310734695576349 GO:0016776 phosphotransferase activity, phosphate group as acceptor 12/2997 39/18639 0.307692307692308 1.91360591360591 0.0163662121064668 0.312127045173331 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 8/2997 22/18639 0.363636363636364 2.26153426153426 0.0170190246847116 0.316116592201997 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 7/2997 18/18639 0.388888888888889 2.41858525191859 0.0170612093960221 0.316116592201997 GO:1901505 carbohydrate derivative transmembrane transporter activity 15/2997 53/18639 0.283018867924528 1.76015638279789 0.0172857762028059 0.316116592201997 GO:0016411 acylglycerol O-acyltransferase activity 10/2997 31/18639 0.32258064516129 2.00619974813523 0.0195995212719687 0.353585958082138 GO:0031406 carboxylic acid binding 41/2997 187/18639 0.219251336898396 1.36357212827801 0.0214842776310028 0.375431798324503 GO:0005484 SNAP receptor activity 11/2997 36/18639 0.305555555555556 1.90031698365032 0.0222165633465436 0.375431798324503 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 11/2997 36/18639 0.305555555555556 1.90031698365032 0.0222165633465436 0.375431798324503 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 11/2997 36/18639 0.305555555555556 1.90031698365032 0.0222165633465436 0.375431798324503 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 11/2997 36/18639 0.305555555555556 1.90031698365032 0.0222165633465436 0.375431798324503 GO:0004602 glutathione peroxidase activity 8/2997 23/18639 0.347826086956522 2.16320668494582 0.0225007203708854 0.37548077118915 GO:0048020 CCR chemokine receptor binding 14/2997 50/18639 0.28 1.74138138138138 0.0230522547219338 0.376193667944389 GO:0050145 nucleoside monophosphate kinase activity 7/2997 19/18639 0.368421052631579 2.29129129129129 0.0233427190318955 0.376193667944389 GO:0016798 hydrolase activity, acting on glycosyl bonds 30/2997 130/18639 0.230769230769231 1.43520443520444 0.0233888198047823 0.376193667944389 GO:0008378 galactosyltransferase activity 10/2997 32/18639 0.3125 1.94350600600601 0.0245073043505435 0.384908838917359 GO:0120015 sterol transfer activity 10/2997 32/18639 0.3125 1.94350600600601 0.0245073043505435 0.384908838917359 GO:0043177 organic acid binding 41/2997 189/18639 0.216931216931217 1.34914279358724 0.0252966108032601 0.390209039548251 GO:0038024 cargo receptor activity 17/2997 65/18639 0.261538461538462 1.62656502656503 0.0254293531390995 0.390209039548251 GO:0004857 enzyme inhibitor activity 82/2997 416/18639 0.197115384615385 1.22590378840379 0.0265314083990826 0.402493525145174 GO:0015026 coreceptor activity 16/2997 61/18639 0.262295081967213 1.63127061487717 0.0288265060283743 0.425052883463191 GO:0016859 cis-trans isomerase activity 12/2997 42/18639 0.285714285714286 1.77691977691978 0.0291984949006217 0.425052883463191 GO:0001618 virus receptor activity 20/2997 81/18639 0.246913580246914 1.53560968375783 0.0296375882339748 0.425052883463191 GO:0015101 organic cation transmembrane transporter activity 20/2997 81/18639 0.246913580246914 1.53560968375783 0.0296375882339748 0.425052883463191 GO:0051536 iron-sulfur cluster binding 19/2997 76/18639 0.25 1.5548048048048 0.0296552065874636 0.425052883463191 GO:0030296 protein tyrosine kinase activator activity 10/2997 33/18639 0.303030303030303 1.88461188461188 0.0302393834278305 0.425052883463191 GO:0043022 ribosome binding 26/2997 112/18639 0.232142857142857 1.44374731874732 0.0308696324429564 0.425052883463191 GO:0015095 magnesium ion transmembrane transporter activity 7/2997 20/18639 0.35 2.17672672672673 0.0310491551079318 0.425052883463191 GO:0016004 phospholipase activator activity 7/2997 20/18639 0.35 2.17672672672673 0.0310491551079318 0.425052883463191 GO:0016208 AMP binding 5/2997 12/18639 0.416666666666667 2.59134134134134 0.0315207756276074 0.425052883463191 GO:0070008 serine-type exopeptidase activity 5/2997 12/18639 0.416666666666667 2.59134134134134 0.0315207756276074 0.425052883463191 GO:0140272 exogenous protein binding 20/2997 82/18639 0.24390243902439 1.51688273639493 0.033463658157956 0.44446044430533 GO:0051540 metal cluster binding 19/2997 77/18639 0.246753246753247 1.53461253461253 0.0336258463481935 0.44446044430533 GO:0019842 vitamin binding 33/2997 150/18639 0.22 1.36822822822823 0.0345187310238412 0.451789273694392 GO:0008194 UDP-glycosyltransferase activity 32/2997 145/18639 0.220689655172414 1.37251734493114 0.0354893990535178 0.459983958606274 GO:0001540 amyloid-beta binding 20/2997 83/18639 0.240963855421687 1.49860704077572 0.0376447132615206 0.483227809655096 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 11/2997 39/18639 0.282051282051282 1.75413875413875 0.0392929226730597 0.499581445414616 GO:0019838 growth factor binding 30/2997 136/18639 0.220588235294118 1.37188659247483 0.0409253083745007 0.509656435490769 GO:0019205 nucleobase-containing compound kinase activity 12/2997 44/18639 0.272727272727273 1.6961506961507 0.041033642325759 0.509656435490769 GO:0016835 carbon-oxygen lyase activity 19/2997 79/18639 0.240506329113924 1.49576158436918 0.0427248790503127 0.509656435490769 GO:0004550 nucleoside diphosphate kinase activity 6/2997 17/18639 0.352941176470588 2.19501854795972 0.0431323095697877 0.509656435490769 GO:0008484 sulfuric ester hydrolase activity 6/2997 17/18639 0.352941176470588 2.19501854795972 0.0431323095697877 0.509656435490769 GO:0038191 neuropilin binding 6/2997 17/18639 0.352941176470588 2.19501854795972 0.0431323095697877 0.509656435490769 GO:0051787 misfolded protein binding 6/2997 17/18639 0.352941176470588 2.19501854795972 0.0431323095697877 0.509656435490769 GO:0048029 monosaccharide binding 18/2997 74/18639 0.243243243243243 1.51278305332359 0.0431394585846119 0.509656435490769 GO:0016853 isomerase activity 38/2997 180/18639 0.211111111111111 1.31294627961295 0.0440844438634217 0.515532977776234 GO:0016229 steroid dehydrogenase activity 10/2997 35/18639 0.285714285714286 1.77691977691978 0.0444092078234209 0.515532977776234 GO:0043548 phosphatidylinositol 3-kinase binding 8/2997 26/18639 0.307692307692308 1.91360591360591 0.0460935946700196 0.530473697279967 GO:0033218 amide binding 50/2997 247/18639 0.202429149797571 1.25895125895126 0.047070261476547 0.537083752745215 GO:0034062 5'-3' RNA polymerase activity 7/2997 22/18639 0.318181818181818 1.97884247884248 0.0511503720390588 0.573829803967592 GO:0097747 RNA polymerase activity 7/2997 22/18639 0.318181818181818 1.97884247884248 0.0511503720390588 0.573829803967592 GO:0017080 sodium channel regulator activity 11/2997 41/18639 0.268292682926829 1.66857101003442 0.0547641331320929 0.593431119332067 GO:0061650 ubiquitin-like protein conjugating enzyme activity 11/2997 41/18639 0.268292682926829 1.66857101003442 0.0547641331320929 0.593431119332067 GO:0035591 signaling adaptor activity 28/2997 129/18639 0.217054263565891 1.34990804758247 0.0560938741868264 0.593431119332067 GO:0016854 racemase and epimerase activity 6/2997 18/18639 0.333333333333333 2.07307307307307 0.0561678596566707 0.593431119332067 GO:0030228 lipoprotein particle receptor activity 6/2997 18/18639 0.333333333333333 2.07307307307307 0.0561678596566707 0.593431119332067 GO:0030170 pyridoxal phosphate binding 14/2997 56/18639 0.25 1.5548048048048 0.0565177525183241 0.593431119332067 GO:0005385 zinc ion transmembrane transporter activity 8/2997 27/18639 0.296296296296296 1.8427316205094 0.05659149722442 0.593431119332067 GO:0015252 proton channel activity 8/2997 27/18639 0.296296296296296 1.8427316205094 0.05659149722442 0.593431119332067 GO:0043178 alcohol binding 21/2997 92/18639 0.228260869565217 1.41960438699569 0.056898264625097 0.593431119332067 GO:0061135 endopeptidase regulator activity 38/2997 184/18639 0.206521739130435 1.28440396918658 0.0586312434613508 0.593526384539103 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 9/2997 32/18639 0.28125 1.74915540540541 0.0602023496621498 0.593526384539103 GO:0005161 platelet-derived growth factor receptor binding 5/2997 14/18639 0.357142857142857 2.22114972114972 0.060450237368248 0.593526384539103 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 5/2997 14/18639 0.357142857142857 2.22114972114972 0.060450237368248 0.593526384539103 GO:0044548 S100 protein binding 5/2997 14/18639 0.357142857142857 2.22114972114972 0.060450237368248 0.593526384539103 GO:0042379 chemokine receptor binding 17/2997 72/18639 0.236111111111111 1.46842676009343 0.0618569252658364 0.593526384539103 GO:0005528 FK506 binding 4/2997 10/18639 0.4 2.48768768768769 0.0622684612368531 0.593526384539103 GO:0016868 intramolecular phosphotransferase activity 4/2997 10/18639 0.4 2.48768768768769 0.0622684612368531 0.593526384539103 GO:0033204 ribonuclease P RNA binding 4/2997 10/18639 0.4 2.48768768768769 0.0622684612368531 0.593526384539103 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 4/2997 10/18639 0.4 2.48768768768769 0.0622684612368531 0.593526384539103 GO:0015179 L-amino acid transmembrane transporter activity 15/2997 62/18639 0.241935483870968 1.50464981110142 0.0636743655575072 0.593526384539103 GO:0008171 O-methyltransferase activity 7/2997 23/18639 0.304347826086957 1.89280584932759 0.0636845946438846 0.593526384539103 GO:0042171 lysophosphatidic acid acyltransferase activity 7/2997 23/18639 0.304347826086957 1.89280584932759 0.0636845946438846 0.593526384539103 GO:0071617 lysophospholipid acyltransferase activity 7/2997 23/18639 0.304347826086957 1.89280584932759 0.0636845946438846 0.593526384539103 GO:0016779 nucleotidyltransferase activity 29/2997 136/18639 0.213235294117647 1.32615703939233 0.0639107791105209 0.593526384539103 GO:0070279 vitamin B6 binding 14/2997 57/18639 0.245614035087719 1.52752752752753 0.0642705720333109 0.593526384539103 GO:0043495 protein-membrane adaptor activity 12/2997 47/18639 0.25531914893617 1.58788575809852 0.0644654125529363 0.593526384539103 GO:0017124 SH3 domain binding 25/2997 115/18639 0.217391304347826 1.35200417809113 0.067012531461101 0.612751571921711 GO:0004521 RNA endonuclease activity 17/2997 73/18639 0.232876712328767 1.44831132502365 0.0690424767534634 0.625259356676929 GO:0004540 RNA nuclease activity 26/2997 121/18639 0.214876033057851 1.33636115454297 0.0705456159240843 0.625259356676929 GO:0003756 protein disulfide isomerase activity 6/2997 19/18639 0.315789473684211 1.96396396396396 0.0713179245604129 0.625259356676929 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 6/2997 19/18639 0.315789473684211 1.96396396396396 0.0713179245604129 0.625259356676929 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 6/2997 19/18639 0.315789473684211 1.96396396396396 0.0713179245604129 0.625259356676929 GO:0140311 protein sequestering activity 9/2997 33/18639 0.272727272727273 1.6961506961507 0.0714384620000194 0.625259356676929 GO:0005507 copper ion binding 15/2997 63/18639 0.238095238095238 1.48076648076648 0.0716589375067941 0.625259356676929 GO:0043021 ribonucleoprotein complex binding 36/2997 177/18639 0.203389830508475 1.26492594289204 0.0769456018329432 0.632347155595298 GO:0005041 low-density lipoprotein particle receptor activity 5/2997 15/18639 0.333333333333333 2.07307307307307 0.079079650120794 0.632347155595298 GO:0015929 hexosaminidase activity 5/2997 15/18639 0.333333333333333 2.07307307307307 0.079079650120794 0.632347155595298 GO:0031005 filamin binding 5/2997 15/18639 0.333333333333333 2.07307307307307 0.079079650120794 0.632347155595298 GO:0033130 acetylcholine receptor binding 5/2997 15/18639 0.333333333333333 2.07307307307307 0.079079650120794 0.632347155595298 GO:0019208 phosphatase regulator activity 25/2997 117/18639 0.213675213675214 1.32889299555966 0.0791182914559229 0.632347155595298 GO:0031625 ubiquitin protein ligase binding 58/2997 302/18639 0.19205298013245 1.19441958514806 0.0812368439252606 0.632347155595298 GO:0005125 cytokine activity 46/2997 234/18639 0.196581196581197 1.22258155591489 0.0817810884971649 0.632347155595298 GO:0035250 UDP-galactosyltransferase activity 8/2997 29/18639 0.275862068965517 1.71564668116392 0.0818018290602114 0.632347155595298 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 14/2997 59/18639 0.23728813559322 1.47574693337405 0.0818239486537708 0.632347155595298 GO:0005319 lipid transporter activity 36/2997 178/18639 0.202247191011236 1.25781961737018 0.0821020333780106 0.632347155595298 GO:0048306 calcium-dependent protein binding 18/2997 80/18639 0.225 1.39932432432432 0.0827304402855844 0.632347155595298 GO:0003925 G protein activity 13/2997 54/18639 0.240740740740741 1.49721944166389 0.0831518563878233 0.632347155595298 GO:0003725 double-stranded RNA binding 17/2997 75/18639 0.226666666666667 1.40968968968969 0.0850424050617891 0.632347155595298 GO:0019003 GDP binding 17/2997 75/18639 0.226666666666667 1.40968968968969 0.0850424050617891 0.632347155595298 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 20/2997 91/18639 0.21978021978022 1.36686136686137 0.0856137316919012 0.632347155595298 GO:0000099 sulfur amino acid transmembrane transporter activity 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0005225 volume-sensitive anion channel activity 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0008199 ferric iron binding 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0008271 secondary active sulfate transmembrane transporter activity 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0015173 aromatic amino acid transmembrane transporter activity 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0019206 nucleoside kinase activity 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0180030 inositol phosphate kinase activity 4/2997 11/18639 0.363636363636364 2.26153426153426 0.0857731399695907 0.632347155595298 GO:0016782 transferase activity, transferring sulphur-containing groups 16/2997 70/18639 0.228571428571429 1.42153582153582 0.0873216574020401 0.632347155595298 GO:0097110 scaffold protein binding 16/2997 70/18639 0.228571428571429 1.42153582153582 0.0873216574020401 0.632347155595298 GO:0008238 exopeptidase activity 22/2997 102/18639 0.215686274509804 1.34140022375317 0.0875401066601054 0.632347155595298 GO:0005126 cytokine receptor binding 53/2997 275/18639 0.192727272727273 1.19861315861316 0.0875940193114952 0.632347155595298 GO:0016209 antioxidant activity 19/2997 86/18639 0.22093023255814 1.37401354843215 0.0883302741834122 0.632347155595298 GO:0050660 flavin adenine dinucleotide binding 19/2997 86/18639 0.22093023255814 1.37401354843215 0.0883302741834122 0.632347155595298 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6/2997 20/18639 0.3 1.86576576576577 0.0885759686114762 0.632347155595298 GO:0031418 L-ascorbic acid binding 6/2997 20/18639 0.3 1.86576576576577 0.0885759686114762 0.632347155595298 GO:0003779 actin binding 82/2997 443/18639 0.18510158013544 1.15118730468618 0.0911044024494999 0.645820691320726 GO:0004714 transmembrane receptor protein tyrosine kinase activity 14/2997 60/18639 0.233333333333333 1.45115115115115 0.0916457469300314 0.645820691320726 GO:0044389 ubiquitin-like protein ligase binding 61/2997 322/18639 0.18944099378882 1.17817506947942 0.0928174034064831 0.645820691320726 GO:0008374 O-acyltransferase activity 13/2997 55/18639 0.236363636363636 1.46999726999727 0.0935906995274968 0.645820691320726 GO:0140313 molecular sequestering activity 13/2997 55/18639 0.236363636363636 1.46999726999727 0.0935906995274968 0.645820691320726 GO:0005537 D-mannose binding 7/2997 25/18639 0.28 1.74138138138138 0.0938495985889295 0.645820691320726 GO:0008483 transaminase activity 7/2997 25/18639 0.28 1.74138138138138 0.0938495985889295 0.645820691320726 GO:0045296 cadherin binding 63/2997 334/18639 0.188622754491018 1.17308625991261 0.0949046010833392 0.649731499724399 GO:0001968 fibronectin binding 8/2997 30/18639 0.266666666666667 1.65845845845846 0.0965334702299135 0.651764758858498 GO:0042605 peptide antigen binding 11/2997 45/18639 0.244444444444444 1.52025358692025 0.0966388213327991 0.651764758858498 GO:0140299 molecular sensor activity 16/2997 71/18639 0.225352112676056 1.40151419024658 0.0966662338981144 0.651764758858498 GO:0042277 peptide binding 48/2997 249/18639 0.192771084337349 1.19888563262057 0.0994249525187601 0.666996540766556 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 5/2997 16/18639 0.3125 1.94350600600601 0.100402208999938 0.670184745074589 GO:0004197 cysteine-type endopeptidase activity 19/2997 88/18639 0.215909090909091 1.34278596778597 0.10564181492929 0.686981404546774 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 6/2997 21/18639 0.285714285714286 1.77691977691978 0.107890196903724 0.686981404546774 GO:0008373 sialyltransferase activity 6/2997 21/18639 0.285714285714286 1.77691977691978 0.107890196903724 0.686981404546774 GO:0005160 transforming growth factor beta receptor binding 7/2997 26/18639 0.269230769230769 1.67440517440517 0.111443915822212 0.686981404546774 GO:0008198 ferrous iron binding 7/2997 26/18639 0.269230769230769 1.67440517440517 0.111443915822212 0.686981404546774 GO:0005452 solute:inorganic anion antiporter activity 8/2997 31/18639 0.258064516129032 1.60495979850819 0.112662288338315 0.686981404546774 GO:0000995 RNA polymerase III general transcription initiation factor activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0004526 ribonuclease P activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0005527 macrolide binding 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0016801 hydrolase activity, acting on ether bonds 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0016803 ether hydrolase activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0016840 carbon-nitrogen lyase activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0034452 dynactin binding 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0140829 bicarbonate:monoatomic anion antiporter activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0140900 chloride:bicarbonate antiporter activity 4/2997 12/18639 0.333333333333333 2.07307307307307 0.112899322140582 0.686981404546774 GO:0019199 transmembrane receptor protein kinase activity 17/2997 78/18639 0.217948717948718 1.35547085547086 0.113210418726809 0.686981404546774 GO:0004866 endopeptidase inhibitor activity 32/2997 161/18639 0.198757763975155 1.23611810568332 0.115017809023258 0.694790837312441 GO:0004601 peroxidase activity 13/2997 57/18639 0.228070175438596 1.41841841841842 0.116773048894858 0.699067355491638 GO:0015932 nucleobase-containing compound transmembrane transporter activity 13/2997 57/18639 0.228070175438596 1.41841841841842 0.116773048894858 0.699067355491638 GO:0030159 signaling receptor complex adaptor activity 12/2997 52/18639 0.230769230769231 1.43520443520444 0.12006712550396 0.715578627445478 GO:0004549 tRNA-specific ribonuclease activity 5/2997 17/18639 0.294117647058824 1.82918212329977 0.124264667095835 0.727602327074294 GO:0008429 phosphatidylethanolamine binding 5/2997 17/18639 0.294117647058824 1.82918212329977 0.124264667095835 0.727602327074294 GO:0017110 nucleoside diphosphate phosphatase activity 5/2997 17/18639 0.294117647058824 1.82918212329977 0.124264667095835 0.727602327074294 GO:0070492 oligosaccharide binding 5/2997 17/18639 0.294117647058824 1.82918212329977 0.124264667095835 0.727602327074294 GO:1901682 sulfur compound transmembrane transporter activity 14/2997 63/18639 0.222222222222222 1.38204871538205 0.125325080641444 0.730606911163004 GO:0061133 endopeptidase activator activity 6/2997 22/18639 0.272727272727273 1.6961506961507 0.129167631227973 0.742159234946686 GO:0019888 protein phosphatase regulator activity 22/2997 107/18639 0.205607476635514 1.27871797030676 0.129765505578943 0.742159234946686 GO:0015106 bicarbonate transmembrane transporter activity 8/2997 32/18639 0.25 1.5548048048048 0.130148934563703 0.742159234946686 GO:0022884 macromolecule transmembrane transporter activity 8/2997 32/18639 0.25 1.5548048048048 0.130148934563703 0.742159234946686 GO:0042910 xenobiotic transmembrane transporter activity 8/2997 32/18639 0.25 1.5548048048048 0.130148934563703 0.742159234946686 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 7/2997 27/18639 0.259259259259259 1.61239016794572 0.130642262331439 0.742159234946686 GO:0030414 peptidase inhibitor activity 33/2997 169/18639 0.195266272189349 1.21440375286529 0.132247021771911 0.748092262989411 GO:0019887 protein kinase regulator activity 48/2997 255/18639 0.188235294117647 1.17067655891185 0.133133198748599 0.749927511938311 GO:0016791 phosphatase activity 51/2997 273/18639 0.186813186813187 1.16183216183216 0.137152766441841 0.769323290755703 GO:0060589 nucleoside-triphosphatase regulator activity 88/2997 490/18639 0.179591836734694 1.11692100263529 0.139231021576142 0.777713028469244 GO:0001664 G protein-coupled receptor binding 55/2997 297/18639 0.185185185185185 1.15170726281837 0.141862615602301 0.780599158169224 GO:0005542 folic acid binding 4/2997 13/18639 0.307692307692308 1.91360591360591 0.143256025281992 0.780599158169224 GO:0035673 oligopeptide transmembrane transporter activity 4/2997 13/18639 0.307692307692308 1.91360591360591 0.143256025281992 0.780599158169224 GO:0039706 co-receptor binding 4/2997 13/18639 0.307692307692308 1.91360591360591 0.143256025281992 0.780599158169224 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/2997 13/18639 0.307692307692308 1.91360591360591 0.143256025281992 0.780599158169224 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/2997 13/18639 0.307692307692308 1.91360591360591 0.143256025281992 0.780599158169224 GO:0050661 NADP binding 12/2997 54/18639 0.222222222222222 1.38204871538205 0.148145457644384 0.792416504080824 GO:0005506 iron ion binding 30/2997 154/18639 0.194805194805195 1.21153621153621 0.148565279060129 0.792416504080824 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 8/2997 33/18639 0.242424242424242 1.50768950768951 0.148936285784081 0.792416504080824 GO:0019956 chemokine binding 8/2997 33/18639 0.242424242424242 1.50768950768951 0.148936285784081 0.792416504080824 GO:0000900 mRNA regulatory element binding translation repressor activity 5/2997 18/18639 0.277777777777778 1.72756089422756 0.150455746880128 0.792416504080824 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 5/2997 18/18639 0.277777777777778 1.72756089422756 0.150455746880128 0.792416504080824 GO:0017128 phospholipid scramblase activity 5/2997 18/18639 0.277777777777778 1.72756089422756 0.150455746880128 0.792416504080824 GO:1990381 ubiquitin-specific protease binding 5/2997 18/18639 0.277777777777778 1.72756089422756 0.150455746880128 0.792416504080824 GO:0120013 lipid transfer activity 14/2997 65/18639 0.215384615384615 1.33952413952414 0.151225336675584 0.792416504080824 GO:0051019 mitogen-activated protein kinase binding 7/2997 28/18639 0.25 1.5548048048048 0.151360455835663 0.792416504080824 GO:0043274 phospholipase binding 6/2997 23/18639 0.260869565217391 1.62240501370936 0.152279291198828 0.794112709962638 GO:0016763 pentosyltransferase activity 11/2997 49/18639 0.224489795918367 1.39615125329411 0.153402073630837 0.796855129560964 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 13/2997 60/18639 0.216666666666667 1.3474974974975 0.157178559911276 0.813307664657184 GO:0005085 guanyl-nucleotide exchange factor activity 43/2997 230/18639 0.18695652173913 1.16272359315838 0.159296167320763 0.821082561286556 GO:0030695 GTPase regulator activity 87/2997 489/18639 0.177914110429448 1.10648685495311 0.162835645886002 0.836098412530051 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 9/2997 39/18639 0.230769230769231 1.43520443520444 0.16392860903063 0.838485414007247 GO:0005006 epidermal growth factor receptor activity 11/2997 50/18639 0.22 1.36822822822823 0.169792030792791 0.846064557541464 GO:0005007 fibroblast growth factor receptor activity 11/2997 50/18639 0.22 1.36822822822823 0.169792030792791 0.846064557541464 GO:0005017 platelet-derived growth factor receptor activity 11/2997 50/18639 0.22 1.36822822822823 0.169792030792791 0.846064557541464 GO:0005019 platelet-derived growth factor beta-receptor activity 11/2997 50/18639 0.22 1.36822822822823 0.169792030792791 0.846064557541464 GO:0015605 organophosphate ester transmembrane transporter activity 11/2997 50/18639 0.22 1.36822822822823 0.169792030792791 0.846064557541464 GO:0005525 GTP binding 68/2997 378/18639 0.17989417989418 1.11880134102356 0.170432822293625 0.846064557541464 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 13/2997 61/18639 0.213114754098361 1.3254073745877 0.172076422686175 0.846064557541464 GO:0061134 peptidase regulator activity 42/2997 226/18639 0.185840707964602 1.15578410268676 0.172824647467785 0.846064557541464 GO:0003785 actin monomer binding 7/2997 29/18639 0.241379310344828 1.50119084601843 0.173492746173307 0.846064557541464 GO:0043236 laminin binding 7/2997 29/18639 0.241379310344828 1.50119084601843 0.173492746173307 0.846064557541464 GO:0005545 1-phosphatidylinositol binding 4/2997 14/18639 0.285714285714286 1.77691977691978 0.17637834044749 0.846064557541464 GO:0008191 metalloendopeptidase inhibitor activity 4/2997 14/18639 0.285714285714286 1.77691977691978 0.17637834044749 0.846064557541464 GO:0008559 ABC-type xenobiotic transporter activity 4/2997 14/18639 0.285714285714286 1.77691977691978 0.17637834044749 0.846064557541464 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 4/2997 14/18639 0.285714285714286 1.77691977691978 0.17637834044749 0.846064557541464 GO:0071933 Arp2/3 complex binding 4/2997 14/18639 0.285714285714286 1.77691977691978 0.17637834044749 0.846064557541464 GO:0004715 non-membrane spanning protein tyrosine kinase activity 10/2997 45/18639 0.222222222222222 1.38204871538205 0.176423925610695 0.846064557541464 GO:0015295 solute:proton symporter activity 6/2997 24/18639 0.25 1.5548048048048 0.177066071990816 0.846064557541464 GO:0019957 C-C chemokine binding 6/2997 24/18639 0.25 1.5548048048048 0.177066071990816 0.846064557541464 GO:0005346 purine ribonucleotide transmembrane transporter activity 5/2997 19/18639 0.263157894736842 1.63663663663664 0.178719254851455 0.846064557541464 GO:0034987 immunoglobulin receptor binding 5/2997 19/18639 0.263157894736842 1.63663663663664 0.178719254851455 0.846064557541464 GO:0046527 glucosyltransferase activity 5/2997 19/18639 0.263157894736842 1.63663663663664 0.178719254851455 0.846064557541464 GO:0050997 quaternary ammonium group binding 9/2997 40/18639 0.225 1.39932432432432 0.183222788499051 0.864319514651002 GO:0004860 protein kinase inhibitor activity 17/2997 84/18639 0.202380952380952 1.25865150865151 0.184347433223737 0.866562758287635 GO:0005010 insulin-like growth factor receptor activity 11/2997 51/18639 0.215686274509804 1.34140022375317 0.186988524794484 0.87050554505013 GO:0005030 neurotrophin receptor activity 11/2997 51/18639 0.215686274509804 1.34140022375317 0.186988524794484 0.87050554505013 GO:0042578 phosphoric ester hydrolase activity 65/2997 363/18639 0.179063360881543 1.11363429545248 0.187142390583811 0.87050554505013 GO:0019210 kinase inhibitor activity 18/2997 90/18639 0.2 1.24384384384384 0.189508790805347 0.878170024019623 GO:0061631 ubiquitin conjugating enzyme activity 8/2997 35/18639 0.228571428571429 1.42153582153582 0.190105720555559 0.878170024019623 GO:0015291 secondary active transmembrane transporter activity 52/2997 287/18639 0.181184668989547 1.12682717560766 0.191754286176129 0.882730938086665 GO:0004180 carboxypeptidase activity 10/2997 46/18639 0.217391304347826 1.35200417809113 0.195026194599274 0.886204313427173 GO:0031210 phosphatidylcholine binding 7/2997 30/18639 0.233333333333333 1.45115115115115 0.196915134503905 0.886204313427173 GO:0000030 mannosyltransferase activity 6/2997 25/18639 0.24 1.49261261261261 0.203344958328255 0.886204313427173 GO:0019211 phosphatase activator activity 6/2997 25/18639 0.24 1.49261261261261 0.203344958328255 0.886204313427173 GO:0047617 fatty acyl-CoA hydrolase activity 6/2997 25/18639 0.24 1.49261261261261 0.203344958328255 0.886204313427173 GO:0140318 protein transporter activity 9/2997 41/18639 0.219512195121951 1.36519446275544 0.203465908806698 0.886204313427173 GO:0004090 carbonyl reductase (NADPH) activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0004955 prostaglandin receptor activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0005031 tumor necrosis factor receptor activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0016783 sulfurtransferase activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0019911 structural constituent of myelin sheath 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0043208 glycosphingolipid binding 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0047429 nucleoside triphosphate diphosphatase activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0050308 sugar-phosphatase activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0098505 G-rich strand telomeric DNA binding 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0140135 mechanosensitive monoatomic cation channel activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0140940 histone H2A methyltransferase activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:1990259 histone H2AQ104 methyltransferase activity 3/2997 10/18639 0.3 1.86576576576577 0.208517178709187 0.886204313427173 GO:0001972 retinoic acid binding 5/2997 20/18639 0.25 1.5548048048048 0.208767016931448 0.886204313427173 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 5/2997 20/18639 0.25 1.5548048048048 0.208767016931448 0.886204313427173 GO:0042288 MHC class I protein binding 5/2997 20/18639 0.25 1.5548048048048 0.208767016931448 0.886204313427173 GO:0003924 GTPase activity 59/2997 331/18639 0.178247734138973 1.10856173393938 0.211008004331937 0.886204313427173 GO:0004559 alpha-mannosidase activity 4/2997 15/18639 0.266666666666667 1.65845845845846 0.211759682384471 0.886204313427173 GO:0015116 sulfate transmembrane transporter activity 4/2997 15/18639 0.266666666666667 1.65845845845846 0.211759682384471 0.886204313427173 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/2997 15/18639 0.266666666666667 1.65845845845846 0.211759682384471 0.886204313427173 GO:0051371 muscle alpha-actinin binding 4/2997 15/18639 0.266666666666667 1.65845845845846 0.211759682384471 0.886204313427173 GO:0008146 sulfotransferase activity 11/2997 53/18639 0.207547169811321 1.29078134738512 0.223601301925277 0.919148215840116 GO:0004518 nuclease activity 38/2997 209/18639 0.181818181818182 1.13076713076713 0.227505477853765 0.919148215840116 GO:0016289 acyl-CoA hydrolase activity 6/2997 26/18639 0.230769230769231 1.43520443520444 0.230915271080068 0.919148215840116 GO:0050681 nuclear androgen receptor binding 6/2997 26/18639 0.230769230769231 1.43520443520444 0.230915271080068 0.919148215840116 GO:0070412 R-SMAD binding 6/2997 26/18639 0.230769230769231 1.43520443520444 0.230915271080068 0.919148215840116 GO:0017022 myosin binding 15/2997 76/18639 0.197368421052632 1.22747747747748 0.232472396355792 0.919148215840116 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 23/2997 122/18639 0.188524590163934 1.17247575444297 0.233734526366338 0.919148215840116 GO:0019001 guanyl nucleotide binding 70/2997 400/18639 0.175 1.08836336336336 0.235603238987862 0.919148215840116 GO:0032561 guanyl ribonucleotide binding 70/2997 400/18639 0.175 1.08836336336336 0.235603238987862 0.919148215840116 GO:0008514 organic anion transmembrane transporter activity 48/2997 269/18639 0.178438661710037 1.10974915435882 0.23602144444469 0.919148215840116 GO:0019207 kinase regulator activity 51/2997 287/18639 0.177700348432056 1.10515742223059 0.237671125933901 0.919148215840116 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 5/2997 21/18639 0.238095238095238 1.48076648076648 0.240291023190112 0.919148215840116 GO:0072542 protein phosphatase activator activity 5/2997 21/18639 0.238095238095238 1.48076648076648 0.240291023190112 0.919148215840116 GO:0004713 protein tyrosine kinase activity 26/2997 140/18639 0.185714285714286 1.15499785499786 0.240785290943114 0.919148215840116 GO:0051287 NAD binding 11/2997 54/18639 0.203703703703704 1.26687798910021 0.242903959764576 0.919148215840116 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 9/2997 43/18639 0.209302325581395 1.30169704588309 0.246462722654152 0.919148215840116 GO:0000062 fatty-acyl-CoA binding 4/2997 16/18639 0.25 1.5548048048048 0.248878840179314 0.919148215840116 GO:0003688 DNA replication origin binding 4/2997 16/18639 0.25 1.5548048048048 0.248878840179314 0.919148215840116 GO:0015923 mannosidase activity 4/2997 16/18639 0.25 1.5548048048048 0.248878840179314 0.919148215840116 GO:0022858 alanine transmembrane transporter activity 4/2997 16/18639 0.25 1.5548048048048 0.248878840179314 0.919148215840116 GO:0043023 ribosomal large subunit binding 4/2997 16/18639 0.25 1.5548048048048 0.248878840179314 0.919148215840116 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/2997 16/18639 0.25 1.5548048048048 0.248878840179314 0.919148215840116 GO:0055102 lipase inhibitor activity 4/2997 16/18639 0.25 1.5548048048048 0.248878840179314 0.919148215840116 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/2997 16/18639 0.25 1.5548048048048 0.248878840179314 0.919148215840116 GO:0015297 antiporter activity 25/2997 135/18639 0.185185185185185 1.15170726281837 0.25090842291329 0.919148215840116 GO:0003953 NAD+ nucleosidase activity 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0004954 prostanoid receptor activity 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0005114 type II transforming growth factor beta receptor binding 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0010854 adenylate cyclase regulator activity 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0019107 myristoyltransferase activity 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0019203 carbohydrate phosphatase activity 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0034713 type I transforming growth factor beta receptor binding 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0045294 alpha-catenin binding 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0048185 activin binding 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0050998 nitric-oxide synthase binding 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 3/2997 11/18639 0.272727272727273 1.6961506961507 0.254546193236535 0.919148215840116 GO:0005004 GPI-linked ephrin receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0005008 hepatocyte growth factor receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0005009 insulin receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0005011 macrophage colony-stimulating factor receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0005018 platelet-derived growth factor alpha-receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0005020 stem cell factor receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0008288 boss receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0036332 placental growth factor receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0038062 protein tyrosine kinase collagen receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0060175 brain-derived neurotrophic factor receptor activity 10/2997 49/18639 0.204081632653061 1.26922841208556 0.255407197045878 0.919148215840116 GO:0000287 magnesium ion binding 41/2997 230/18639 0.178260869565217 1.10864342603473 0.258750943416017 0.919148215840116 GO:0005501 retinoid binding 8/2997 38/18639 0.210526315789474 1.30930930930931 0.25936421378217 0.919148215840116 GO:0019840 isoprenoid binding 8/2997 38/18639 0.210526315789474 1.30930930930931 0.25936421378217 0.919148215840116 GO:0001671 ATPase activator activity 6/2997 27/18639 0.222222222222222 1.38204871538205 0.259564702151104 0.919148215840116 GO:0004364 glutathione transferase activity 6/2997 27/18639 0.222222222222222 1.38204871538205 0.259564702151104 0.919148215840116 GO:0004683 calcium/calmodulin-dependent protein kinase activity 6/2997 27/18639 0.222222222222222 1.38204871538205 0.259564702151104 0.919148215840116 GO:0005044 scavenger receptor activity 6/2997 27/18639 0.222222222222222 1.38204871538205 0.259564702151104 0.919148215840116 GO:0008320 protein transmembrane transporter activity 6/2997 27/18639 0.222222222222222 1.38204871538205 0.259564702151104 0.919148215840116 GO:0004867 serine-type endopeptidase inhibitor activity 18/2997 95/18639 0.189473684210526 1.17837837837838 0.260429637925283 0.919771340291673 GO:0030547 signaling receptor inhibitor activity 9/2997 44/18639 0.204545454545455 1.27211302211302 0.269031847852635 0.94764516328039 GO:0008093 cytoskeletal anchor activity 5/2997 22/18639 0.227272727272727 1.41345891345891 0.272974373767212 0.953255527313366 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/2997 22/18639 0.227272727272727 1.41345891345891 0.272974373767212 0.953255527313366 GO:0033691 sialic acid binding 5/2997 22/18639 0.227272727272727 1.41345891345891 0.272974373767212 0.953255527313366 GO:0008237 metallopeptidase activity 33/2997 184/18639 0.179347826086957 1.11540344692519 0.273492537223165 0.953255527313366 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 13/2997 67/18639 0.194029850746269 1.20671417686343 0.274194848305867 0.953255527313366 GO:0005543 phospholipid binding 85/2997 497/18639 0.17102615694165 1.06364916224071 0.282108727331689 0.960373853706992 GO:0033293 monocarboxylic acid binding 15/2997 79/18639 0.189873417721519 1.18086440871251 0.28251564961185 0.960373853706992 GO:0046332 SMAD binding 15/2997 79/18639 0.189873417721519 1.18086440871251 0.28251564961185 0.960373853706992 GO:0019212 phosphatase inhibitor activity 11/2997 56/18639 0.196428571428571 1.22163234663235 0.283184720585356 0.960373853706992 GO:0004659 prenyltransferase activity 4/2997 17/18639 0.235294117647059 1.46334569863982 0.287221662666539 0.960373853706992 GO:0015278 intracellularly gated calcium channel activity 4/2997 17/18639 0.235294117647059 1.46334569863982 0.287221662666539 0.960373853706992 GO:0045125 bioactive lipid receptor activity 4/2997 17/18639 0.235294117647059 1.46334569863982 0.287221662666539 0.960373853706992 GO:1901567 fatty acid derivative binding 4/2997 17/18639 0.235294117647059 1.46334569863982 0.287221662666539 0.960373853706992 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 24/2997 132/18639 0.181818181818182 1.13076713076713 0.28786449075116 0.960373853706992 GO:0050698 proteoglycan sulfotransferase activity 6/2997 28/18639 0.214285714285714 1.33268983268983 0.289074951146224 0.960373853706992 GO:0051539 4 iron, 4 sulfur cluster binding 9/2997 45/18639 0.2 1.24384384384384 0.292183828413119 0.960373853706992 GO:0008083 growth factor activity 29/2997 162/18639 0.179012345679012 1.11331702072443 0.293308042284683 0.960373853706992 GO:0005021 vascular endothelial growth factor receptor activity 10/2997 51/18639 0.196078431372549 1.21945474886651 0.298718906612726 0.960373853706992 GO:0016597 amino acid binding 10/2997 51/18639 0.196078431372549 1.21945474886651 0.298718906612726 0.960373853706992 GO:0003697 single-stranded DNA binding 22/2997 121/18639 0.181818181818182 1.13076713076713 0.298786423441593 0.960373853706992 GO:0008376 acetylgalactosaminyltransferase activity 7/2997 34/18639 0.205882352941176 1.28042748630984 0.300583978884401 0.960373853706992 GO:0015020 glucuronosyltransferase activity 7/2997 34/18639 0.205882352941176 1.28042748630984 0.300583978884401 0.960373853706992 GO:0016831 carboxy-lyase activity 7/2997 34/18639 0.205882352941176 1.28042748630984 0.300583978884401 0.960373853706992 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 7/2997 34/18639 0.205882352941176 1.28042748630984 0.300583978884401 0.960373853706992 GO:0003995 acyl-CoA dehydrogenase activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0008179 adenylate cyclase binding 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0010853 cyclase activator activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0015132 prostaglandin transmembrane transporter activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0016273 arginine N-methyltransferase activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0016274 protein-arginine N-methyltransferase activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0017166 vinculin binding 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0031543 peptidyl-proline dioxygenase activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0035251 UDP-glucosyltransferase activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0035259 nuclear glucocorticoid receptor binding 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0036009 protein-glutamine N-methyltransferase activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0043047 single-stranded telomeric DNA binding 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:1990459 transferrin receptor binding 3/2997 12/18639 0.25 1.5548048048048 0.301761816935186 0.960373853706992 GO:0000295 adenine nucleotide transmembrane transporter activity 5/2997 23/18639 0.217391304347826 1.35200417809113 0.306500785591763 0.960373853706992 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 5/2997 23/18639 0.217391304347826 1.35200417809113 0.306500785591763 0.960373853706992 GO:0005283 amino acid:sodium symporter activity 5/2997 23/18639 0.217391304347826 1.35200417809113 0.306500785591763 0.960373853706992 GO:0016493 C-C chemokine receptor activity 5/2997 23/18639 0.217391304347826 1.35200417809113 0.306500785591763 0.960373853706992 GO:0031681 G-protein beta-subunit binding 5/2997 23/18639 0.217391304347826 1.35200417809113 0.306500785591763 0.960373853706992 GO:0140103 catalytic activity, acting on a glycoprotein 5/2997 23/18639 0.217391304347826 1.35200417809113 0.306500785591763 0.960373853706992 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 5/2997 23/18639 0.217391304347826 1.35200417809113 0.306500785591763 0.960373853706992 GO:0004725 protein tyrosine phosphatase activity 18/2997 98/18639 0.183673469387755 1.142305570877 0.307175756953472 0.960373853706992 GO:0004222 metalloendopeptidase activity 20/2997 110/18639 0.181818181818182 1.13076713076713 0.310544504224124 0.968637647521508 GO:0046943 carboxylic acid transmembrane transporter activity 33/2997 188/18639 0.175531914893617 1.09167145869274 0.318962878384004 0.991087951140333 GO:0099604 ligand-gated calcium channel activity 6/2997 29/18639 0.206896551724138 1.28673501087294 0.319226830704377 0.991087951140333 GO:0015172 acidic amino acid transmembrane transporter activity 4/2997 18/18639 0.222222222222222 1.38204871538205 0.326297638605514 1 GO:0035615 clathrin adaptor activity 4/2997 18/18639 0.222222222222222 1.38204871538205 0.326297638605514 1 GO:0050811 GABA receptor binding 4/2997 18/18639 0.222222222222222 1.38204871538205 0.326297638605514 1 GO:0070628 proteasome binding 4/2997 18/18639 0.222222222222222 1.38204871538205 0.326297638605514 1 GO:0043015 gamma-tubulin binding 7/2997 35/18639 0.2 1.24384384384384 0.328203543466611 1 GO:0005342 organic acid transmembrane transporter activity 33/2997 189/18639 0.174603174603175 1.08589541922875 0.33069236016688 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 8/2997 41/18639 0.195121951219512 1.21350618911595 0.33481418002436 1 GO:0043130 ubiquitin binding 18/2997 100/18639 0.18 1.11945945945946 0.339617340540163 1 GO:0004497 monooxygenase activity 19/2997 106/18639 0.179245283018868 1.11476570910533 0.340510083331383 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 5/2997 24/18639 0.208333333333333 1.29567067067067 0.340562552328855 1 GO:0035035 histone acetyltransferase binding 5/2997 24/18639 0.208333333333333 1.29567067067067 0.340562552328855 1 GO:0050431 transforming growth factor beta binding 5/2997 24/18639 0.208333333333333 1.29567067067067 0.340562552328855 1 GO:0050699 WW domain binding 5/2997 24/18639 0.208333333333333 1.29567067067067 0.340562552328855 1 GO:0070840 dynein complex binding 5/2997 24/18639 0.208333333333333 1.29567067067067 0.340562552328855 1 GO:0044325 transmembrane transporter binding 24/2997 136/18639 0.176470588235294 1.09750927397986 0.342919674824903 1 GO:0099106 ion channel regulator activity 28/2997 160/18639 0.175 1.08836336336336 0.343256531235915 1 GO:0005003 ephrin receptor activity 10/2997 53/18639 0.188679245283019 1.17343758853193 0.343708164530298 1 GO:0005005 transmembrane-ephrin receptor activity 10/2997 53/18639 0.188679245283019 1.17343758853193 0.343708164530298 1 GO:0016860 intramolecular oxidoreductase activity 10/2997 53/18639 0.188679245283019 1.17343758853193 0.343708164530298 1 GO:0017046 peptide hormone binding 10/2997 53/18639 0.188679245283019 1.17343758853193 0.343708164530298 1 GO:0038064 collagen receptor activity 10/2997 53/18639 0.188679245283019 1.17343758853193 0.343708164530298 1 GO:0004465 lipoprotein lipase activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0005035 death receptor activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0008035 high-density lipoprotein particle binding 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0019104 DNA N-glycosylase activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0019855 calcium channel inhibitor activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0031994 insulin-like growth factor I binding 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0061459 L-arginine transmembrane transporter activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0071714 icosanoid transmembrane transporter activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/2997 13/18639 0.230769230769231 1.43520443520444 0.349313554431145 1 GO:0070566 adenylyltransferase activity 6/2997 30/18639 0.2 1.24384384384384 0.349804754754495 1 GO:0051015 actin filament binding 36/2997 209/18639 0.172248803827751 1.07125307125307 0.353143839388721 1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 16/2997 89/18639 0.179775280898876 1.11806188210683 0.354804869993497 1 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 16/2997 89/18639 0.179775280898876 1.11806188210683 0.354804869993497 1 GO:0016874 ligase activity 29/2997 167/18639 0.173652694610778 1.07998417579256 0.356010177905367 1 GO:0044390 ubiquitin-like protein conjugating enzyme binding 7/2997 36/18639 0.194444444444444 1.20929262595929 0.356180129607768 1 GO:0045505 dynein intermediate chain binding 7/2997 36/18639 0.194444444444444 1.20929262595929 0.356180129607768 1 GO:0008017 microtubule binding 47/2997 276/18639 0.170289855072464 1.05906993950472 0.357182814114744 1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/2997 48/18639 0.1875 1.1661036036036 0.36411317337602 1 GO:0005520 insulin-like growth factor binding 4/2997 19/18639 0.210526315789474 1.30930930930931 0.365651874273264 1 GO:0008381 mechanosensitive monoatomic ion channel activity 4/2997 19/18639 0.210526315789474 1.30930930930931 0.365651874273264 1 GO:0042577 lipid phosphatase activity 4/2997 19/18639 0.210526315789474 1.30930930930931 0.365651874273264 1 GO:0043395 heparan sulfate proteoglycan binding 4/2997 19/18639 0.210526315789474 1.30930930930931 0.365651874273264 1 GO:0120227 acyl-CoA binding 4/2997 19/18639 0.210526315789474 1.30930930930931 0.365651874273264 1 GO:0008235 metalloexopeptidase activity 12/2997 66/18639 0.181818181818182 1.13076713076713 0.369902013359163 1 GO:0140793 histone H2AXY142 phosphatase activity 16/2997 90/18639 0.177777777777778 1.10563897230564 0.372553441117152 1 GO:0015171 amino acid transmembrane transporter activity 18/2997 102/18639 0.176470588235294 1.09750927397986 0.372791295188872 1 GO:0003707 nuclear steroid receptor activity 5/2997 25/18639 0.2 1.24384384384384 0.374866950829005 1 GO:0015662 P-type ion transporter activity 5/2997 25/18639 0.2 1.24384384384384 0.374866950829005 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 5/2997 25/18639 0.2 1.24384384384384 0.374866950829005 1 GO:0140358 P-type transmembrane transporter activity 5/2997 25/18639 0.2 1.24384384384384 0.374866950829005 1 GO:0072349 modified amino acid transmembrane transporter activity 6/2997 31/18639 0.193548387096774 1.20371984888114 0.380600564383045 1 GO:0004721 phosphoprotein phosphatase activity 30/2997 175/18639 0.171428571428571 1.06615186615187 0.381146513995921 1 GO:0030295 protein kinase activator activity 24/2997 139/18639 0.172661870503597 1.07382202346231 0.385773166068048 1 GO:0048156 tau protein binding 8/2997 43/18639 0.186046511627907 1.15706404078497 0.386876055605303 1 GO:0035401 histone H3Y41 kinase activity 20/2997 115/18639 0.173913043478261 1.08160334247291 0.388462715685559 1 GO:0140801 histone H2AXY142 kinase activity 20/2997 115/18639 0.173913043478261 1.08160334247291 0.388462715685559 1 GO:0060590 ATPase regulator activity 9/2997 49/18639 0.183673469387755 1.142305570877 0.388572018050302 1 GO:0019905 syntaxin binding 11/2997 61/18639 0.180327868852459 1.12149854772806 0.390393522824335 1 GO:0016500 protein-hormone receptor activity 12/2997 67/18639 0.17910447761194 1.1138900094124 0.390783576643518 1 GO:0141108 transporter regulator activity 29/2997 170/18639 0.170588235294118 1.06092563151387 0.395036677444878 1 GO:0004065 arylsulfatase activity 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0005313 L-glutamate transmembrane transporter activity 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0005347 ATP transmembrane transporter activity 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0008195 phosphatidate phosphatase activity 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0016530 metallochaperone activity 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0031404 chloride ion binding 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0042043 neurexin family protein binding 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0043176 amine binding 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0061665 SUMO ligase activity 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0098847 sequence-specific single stranded DNA binding 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:1901474 azole transmembrane transporter activity 3/2997 14/18639 0.214285714285714 1.33268983268983 0.396477703699414 1 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 22/2997 128/18639 0.171875 1.0689283033033 0.402338921536486 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 4/2997 20/18639 0.2 1.24384384384384 0.404873088608717 1 GO:0010851 cyclase regulator activity 4/2997 20/18639 0.2 1.24384384384384 0.404873088608717 1 GO:0043024 ribosomal small subunit binding 4/2997 20/18639 0.2 1.24384384384384 0.404873088608717 1 GO:0052745 inositol phosphate phosphatase activity 4/2997 20/18639 0.2 1.24384384384384 0.404873088608717 1 GO:0001637 G protein-coupled chemoattractant receptor activity 5/2997 26/18639 0.192307692307692 1.1960036960037 0.409141160293037 1 GO:0004950 chemokine receptor activity 5/2997 26/18639 0.192307692307692 1.1960036960037 0.409141160293037 1 GO:0015216 purine nucleotide transmembrane transporter activity 5/2997 26/18639 0.192307692307692 1.1960036960037 0.409141160293037 1 GO:0030507 spectrin binding 5/2997 26/18639 0.192307692307692 1.1960036960037 0.409141160293037 1 GO:0034237 protein kinase A regulatory subunit binding 5/2997 26/18639 0.192307692307692 1.1960036960037 0.409141160293037 1 GO:0097602 cullin family protein binding 5/2997 26/18639 0.192307692307692 1.1960036960037 0.409141160293037 1 GO:0030515 snoRNA binding 6/2997 32/18639 0.1875 1.1661036036036 0.411416679304751 1 GO:0071813 lipoprotein particle binding 6/2997 32/18639 0.1875 1.1661036036036 0.411416679304751 1 GO:0071814 protein-lipid complex binding 6/2997 32/18639 0.1875 1.1661036036036 0.411416679304751 1 GO:0042162 telomeric DNA binding 7/2997 38/18639 0.184210526315789 1.14564564564565 0.412580110554931 1 GO:0170055 lipid transmembrane transporter activity 10/2997 56/18639 0.178571428571429 1.11057486057486 0.41284541051855 1 GO:0140098 catalytic activity, acting on RNA 64/2997 387/18639 0.165374677002584 1.02850136958664 0.423587288462299 1 GO:0019209 kinase activator activity 25/2997 148/18639 0.168918918918919 1.05054378703027 0.427701176396838 1 GO:0140789 histone phosphatase activity 23/2997 136/18639 0.169117647058824 1.05177972089737 0.431071151417007 1 GO:0140303 intramembrane lipid transporter activity 8/2997 45/18639 0.177777777777778 1.10563897230564 0.439199836552982 1 GO:0000149 SNARE binding 18/2997 106/18639 0.169811320754717 1.05609382967874 0.440314008761242 1 GO:0008509 monoatomic anion transmembrane transporter activity 25/2997 149/18639 0.167785234899329 1.04349315758712 0.441996598658891 1 GO:0140416 transcription regulator inhibitor activity 6/2997 33/18639 0.181818181818182 1.13076713076713 0.442068589318219 1 GO:0004953 icosanoid receptor activity 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0005523 tropomyosin binding 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0016846 carbon-sulfur lyase activity 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0017081 chloride channel regulator activity 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0031386 protein tag activity 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0045504 dynein heavy chain binding 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0050780 dopamine receptor binding 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0061578 K63-linked deubiquitinase activity 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0120283 protein serine/threonine kinase binding 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0141047 molecular tag activity 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0141050 histone H3K deacetylase activity 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0141051 histone H4K deacetylase activity 3/2997 15/18639 0.2 1.24384384384384 0.44265720902815 1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 5/2997 27/18639 0.185185185185185 1.15170726281837 0.443135809870749 1 GO:0035255 ionotropic glutamate receptor binding 5/2997 27/18639 0.185185185185185 1.15170726281837 0.443135809870749 1 GO:0015174 basic amino acid transmembrane transporter activity 4/2997 21/18639 0.19047619047619 1.18461318461318 0.443598280471918 1 GO:0036122 BMP binding 4/2997 21/18639 0.19047619047619 1.18461318461318 0.443598280471918 1 GO:0051010 microtubule plus-end binding 4/2997 21/18639 0.19047619047619 1.18461318461318 0.443598280471918 1 GO:0140312 cargo adaptor activity 4/2997 21/18639 0.19047619047619 1.18461318461318 0.443598280471918 1 GO:0042562 hormone binding 16/2997 94/18639 0.170212765957447 1.05859050539902 0.444430956419746 1 GO:0016247 channel regulator activity 28/2997 168/18639 0.166666666666667 1.03653653653654 0.449893950383513 1 GO:0019903 protein phosphatase binding 24/2997 144/18639 0.166666666666667 1.03653653653654 0.4585700311972 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 30/2997 181/18639 0.165745856353591 1.0308098153402 0.458949108732885 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 9/2997 52/18639 0.173076923076923 1.07640332640333 0.462014531493479 1 GO:0008276 protein methyltransferase activity 16/2997 95/18639 0.168421052631579 1.04744744744745 0.462431077222571 1 GO:0030291 protein serine/threonine kinase inhibitor activity 8/2997 46/18639 0.173913043478261 1.08160334247291 0.465175219749854 1 GO:0004532 RNA exonuclease activity 7/2997 40/18639 0.175 1.08836336336336 0.468607485542688 1 GO:0071949 FAD binding 7/2997 40/18639 0.175 1.08836336336336 0.468607485542688 1 GO:0052866 phosphatidylinositol phosphate phosphatase activity 6/2997 34/18639 0.176470588235294 1.09750927397986 0.472386720125465 1 GO:0005516 calmodulin binding 34/2997 207/18639 0.164251207729469 1.02151426789108 0.47521552371468 1 GO:0016866 intramolecular transferase activity 5/2997 28/18639 0.178571428571429 1.11057486057486 0.476627300897819 1 GO:0019789 SUMO transferase activity 5/2997 28/18639 0.178571428571429 1.11057486057486 0.476627300897819 1 GO:0051393 alpha-actinin binding 5/2997 28/18639 0.178571428571429 1.11057486057486 0.476627300897819 1 GO:0051959 dynein light intermediate chain binding 5/2997 28/18639 0.178571428571429 1.11057486057486 0.476627300897819 1 GO:0097718 disordered domain specific binding 5/2997 28/18639 0.178571428571429 1.11057486057486 0.476627300897819 1 GO:0160215 deacylase activity 11/2997 65/18639 0.169230769230769 1.05248325248325 0.47813858259346 1 GO:0004519 endonuclease activity 21/2997 127/18639 0.165354330708661 1.02837483152444 0.481483811030337 1 GO:0008970 phospholipase A1 activity 4/2997 22/18639 0.181818181818182 1.13076713076713 0.481514704184074 1 GO:0070034 telomerase RNA binding 4/2997 22/18639 0.181818181818182 1.13076713076713 0.481514704184074 1 GO:0140784 metal ion sensor activity 4/2997 22/18639 0.181818181818182 1.13076713076713 0.481514704184074 1 GO:0045309 protein phosphorylated amino acid binding 10/2997 59/18639 0.169491525423729 1.05410495241004 0.481995174102507 1 GO:0015108 chloride transmembrane transporter activity 20/2997 121/18639 0.165289256198347 1.02797011887921 0.484503567714187 1 GO:0046906 tetrapyrrole binding 25/2997 152/18639 0.164473684210526 1.0228978978979 0.48484402544886 1 GO:0004864 protein phosphatase inhibitor activity 9/2997 53/18639 0.169811320754717 1.05609382967874 0.486213561099584 1 GO:0004527 exonuclease activity 14/2997 84/18639 0.166666666666667 1.03653653653654 0.487333263376833 1 GO:0005024 transforming growth factor beta receptor activity 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0005149 interleukin-1 receptor binding 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0005159 insulin-like growth factor receptor binding 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0005521 lamin binding 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0008142 oxysterol binding 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0015562 efflux transmembrane transporter activity 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0016722 oxidoreductase activity, acting on metal ions 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0034450 ubiquitin-ubiquitin ligase activity 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0070411 I-SMAD binding 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0097027 ubiquitin-protein transferase activator activity 3/2997 16/18639 0.1875 1.1661036036036 0.487375294147112 1 GO:0001784 phosphotyrosine residue binding 8/2997 47/18639 0.170212765957447 1.05859050539902 0.490887563177397 1 GO:0005504 fatty acid binding 8/2997 47/18639 0.170212765957447 1.05859050539902 0.490887563177397 1 GO:0005253 monoatomic anion channel activity 17/2997 103/18639 0.16504854368932 1.02647307501676 0.494500066581009 1 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0004382 GDP phosphatase activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0005337 nucleoside transmembrane transporter activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0005345 purine nucleobase transmembrane transporter activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0005381 iron ion transmembrane transporter activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0008239 dipeptidyl-peptidase activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0008401 retinoic acid 4-hydroxylase activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0008519 ammonium channel activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0015187 glycine transmembrane transporter activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0015203 polyamine transmembrane transporter activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0019531 oxalate transmembrane transporter activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0030957 Tat protein binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0031419 cobalamin binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0031434 mitogen-activated protein kinase kinase binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0032395 MHC class II receptor activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0043121 neurotrophin binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0043295 glutathione binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0043422 protein kinase B binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0050815 phosphoserine residue binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0051378 serotonin binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0051864 histone H3K36 demethylase activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0051880 G-quadruplex DNA binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0071723 lipopeptide binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0097177 mitochondrial ribosome binding 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0141109 transporter activator activity 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/2997 10/18639 0.2 1.24384384384384 0.494819185931216 1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 7/2997 41/18639 0.170731707317073 1.06181791547645 0.496153166090579 1 GO:0042169 SH2 domain binding 7/2997 41/18639 0.170731707317073 1.06181791547645 0.496153166090579 1 GO:0042287 MHC protein binding 7/2997 41/18639 0.170731707317073 1.06181791547645 0.496153166090579 1 GO:0005096 GTPase activator activity 44/2997 271/18639 0.162361623616236 1.00976253005773 0.497636789226595 1 GO:0000175 3'-5'-RNA exonuclease activity 6/2997 35/18639 0.171428571428571 1.06615186615187 0.502217722192815 1 GO:0005154 epidermal growth factor receptor binding 6/2997 35/18639 0.171428571428571 1.06615186615187 0.502217722192815 1 GO:0005343 organic acid:sodium symporter activity 6/2997 35/18639 0.171428571428571 1.06615186615187 0.502217722192815 1 GO:0015294 solute:monoatomic cation symporter activity 19/2997 116/18639 0.163793103448276 1.01866521694108 0.503975522668823 1 GO:0004181 metallocarboxypeptidase activity 5/2997 29/18639 0.172413793103448 1.07227917572745 0.509419065521454 1 GO:0004629 phospholipase C activity 5/2997 29/18639 0.172413793103448 1.07227917572745 0.509419065521454 1 GO:0005416 amino acid:monoatomic cation symporter activity 5/2997 29/18639 0.172413793103448 1.07227917572745 0.509419065521454 1 GO:0043539 protein serine/threonine kinase activator activity 12/2997 73/18639 0.164383561643836 1.02233740589905 0.515834540354493 1 GO:0017171 serine hydrolase activity 32/2997 198/18639 0.161616161616162 1.00512633845967 0.517516479315895 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 4/2997 23/18639 0.173913043478261 1.08160334247291 0.518359739677193 1 GO:0005158 insulin receptor binding 4/2997 23/18639 0.173913043478261 1.08160334247291 0.518359739677193 1 GO:0016849 phosphorus-oxygen lyase activity 4/2997 23/18639 0.173913043478261 1.08160334247291 0.518359739677193 1 GO:0020037 heme binding 23/2997 142/18639 0.161971830985915 1.00733832423973 0.52017843836228 1 GO:0048487 beta-tubulin binding 7/2997 42/18639 0.166666666666667 1.03653653653654 0.523233270343957 1 GO:0002020 protease binding 22/2997 136/18639 0.161764705882353 1.00605016781487 0.523905585855964 1 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 3/2997 17/18639 0.176470588235294 1.09750927397986 0.530265358035806 1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/2997 17/18639 0.176470588235294 1.09750927397986 0.530265358035806 1 GO:0008569 minus-end-directed microtubule motor activity 3/2997 17/18639 0.176470588235294 1.09750927397986 0.530265358035806 1 GO:0019198 transmembrane receptor protein phosphatase activity 3/2997 17/18639 0.176470588235294 1.09750927397986 0.530265358035806 1 GO:0030548 acetylcholine receptor regulator activity 3/2997 17/18639 0.176470588235294 1.09750927397986 0.530265358035806 1 GO:0070402 NADPH binding 3/2997 17/18639 0.176470588235294 1.09750927397986 0.530265358035806 1 GO:0070403 NAD+ binding 3/2997 17/18639 0.176470588235294 1.09750927397986 0.530265358035806 1 GO:0004033 aldo-keto reductase (NADPH) activity 6/2997 36/18639 0.166666666666667 1.03653653653654 0.531425240709824 1 GO:0004190 aspartic-type endopeptidase activity 6/2997 36/18639 0.166666666666667 1.03653653653654 0.531425240709824 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 6/2997 36/18639 0.166666666666667 1.03653653653654 0.531425240709824 1 GO:0098632 cell-cell adhesion mediator activity 9/2997 55/18639 0.163636363636364 1.01769041769042 0.533697157996443 1 GO:0005201 extracellular matrix structural constituent 27/2997 168/18639 0.160714285714286 0.999517374517375 0.533811971945121 1 GO:0051213 dioxygenase activity 15/2997 93/18639 0.161290322580645 1.00309987406762 0.538510208466721 1 GO:0051219 phosphoprotein binding 15/2997 93/18639 0.161290322580645 1.00309987406762 0.538510208466721 1 GO:0035254 glutamate receptor binding 8/2997 49/18639 0.163265306122449 1.01538272966844 0.5411537432035 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 5/2997 30/18639 0.166666666666667 1.03653653653654 0.541341927674845 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 5/2997 30/18639 0.166666666666667 1.03653653653654 0.541341927674845 1 GO:0015215 nucleotide transmembrane transporter activity 5/2997 30/18639 0.166666666666667 1.03653653653654 0.541341927674845 1 GO:0031624 ubiquitin conjugating enzyme binding 5/2997 30/18639 0.166666666666667 1.03653653653654 0.541341927674845 1 GO:0048019 receptor antagonist activity 5/2997 30/18639 0.166666666666667 1.03653653653654 0.541341927674845 1 GO:0008236 serine-type peptidase activity 31/2997 194/18639 0.15979381443299 0.993792761833999 0.545662769679991 1 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0002162 dystroglycan binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0005536 D-glucose binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0008172 S-methyltransferase activity 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0015205 nucleobase transmembrane transporter activity 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0015217 ADP transmembrane transporter activity 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0032050 clathrin heavy chain binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0032794 GTPase activating protein binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0034511 U3 snoRNA binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0035252 UDP-xylosyltransferase activity 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0042285 xylosyltransferase activity 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0042608 T cell receptor binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0047676 arachidonate-CoA ligase activity 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0048407 platelet-derived growth factor binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0050786 RAGE receptor binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0070990 snRNP binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0097493 structural molecule activity conferring elasticity 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0140031 phosphorylation-dependent protein binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0140537 transcription regulator activator activity 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:1900750 oligopeptide binding 2/2997 11/18639 0.181818181818182 1.13076713076713 0.548213184307812 1 GO:0004806 triacylglycerol lipase activity 4/2997 24/18639 0.166666666666667 1.03653653653654 0.55391917714686 1 GO:0048027 mRNA 5'-UTR binding 4/2997 24/18639 0.166666666666667 1.03653653653654 0.55391917714686 1 GO:0044183 protein folding chaperone 12/2997 75/18639 0.16 0.995075075075075 0.556119958676612 1 GO:0031267 small GTPase binding 45/2997 283/18639 0.159010600706714 0.988921783974787 0.558111365027729 1 GO:0042805 actinin binding 6/2997 37/18639 0.162162162162162 1.00852203554906 0.559890229962602 1 GO:0043394 proteoglycan binding 6/2997 37/18639 0.162162162162162 1.00852203554906 0.559890229962602 1 GO:0070001 aspartic-type peptidase activity 6/2997 37/18639 0.162162162162162 1.00852203554906 0.559890229962602 1 GO:0032813 tumor necrosis factor receptor superfamily binding 8/2997 50/18639 0.16 0.995075075075075 0.565543993918068 1 GO:0032182 ubiquitin-like protein binding 19/2997 120/18639 0.158333333333333 0.98470970970971 0.567884871796769 1 GO:0070851 growth factor receptor binding 22/2997 139/18639 0.158273381294964 0.984336854840452 0.5682033704572 1 GO:0000400 four-way junction DNA binding 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0008409 5'-3' exonuclease activity 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0008525 phosphatidylcholine transporter activity 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0017075 syntaxin-1 binding 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0034185 apolipoprotein binding 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0070064 proline-rich region binding 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0098641 cadherin binding involved in cell-cell adhesion 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0099602 neurotransmitter receptor regulator activity 3/2997 18/18639 0.166666666666667 1.03653653653654 0.571058901921864 1 GO:0005164 tumor necrosis factor receptor binding 5/2997 31/18639 0.161290322580645 1.00309987406762 0.572253728307884 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 5/2997 31/18639 0.161290322580645 1.00309987406762 0.572253728307884 1 GO:0070273 phosphatidylinositol-4-phosphate binding 5/2997 31/18639 0.161290322580645 1.00309987406762 0.572253728307884 1 GO:0019902 phosphatase binding 30/2997 190/18639 0.157894736842105 0.981981981981982 0.574251756011005 1 GO:0001223 transcription coactivator binding 7/2997 44/18639 0.159090909090909 0.989421239421239 0.575606216754991 1 GO:0098631 cell adhesion mediator activity 12/2997 76/18639 0.157894736842105 0.981981981981982 0.575786945652052 1 GO:0015293 symporter activity 23/2997 146/18639 0.157534246575342 0.979740013986589 0.577819309699952 1 GO:0016504 peptidase activator activity 9/2997 57/18639 0.157894736842105 0.981981981981982 0.579496583152324 1 GO:0004175 endopeptidase activity 64/2997 405/18639 0.158024691358025 0.982790197605012 0.582179162274005 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6/2997 38/18639 0.157894736842105 0.981981981981982 0.58751087735154 1 GO:0043531 ADP binding 6/2997 38/18639 0.157894736842105 0.981981981981982 0.58751087735154 1 GO:0015271 outward rectifier potassium channel activity 4/2997 25/18639 0.16 0.995075075075075 0.588024363112166 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/2997 25/18639 0.16 0.995075075075075 0.588024363112166 1 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/2997 25/18639 0.16 0.995075075075075 0.588024363112166 1 GO:0008168 methyltransferase activity 32/2997 204/18639 0.156862745098039 0.975563799093211 0.590672477876943 1 GO:0015085 calcium ion transmembrane transporter activity 23/2997 147/18639 0.156462585034014 0.973075115932259 0.591846330007904 1 GO:0005025 transforming growth factor beta receptor activity, type I 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0005026 transforming growth factor beta receptor activity, type II 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0005095 GTPase inhibitor activity 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0015269 calcium-activated potassium channel activity 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0016361 activin receptor activity, type I 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0016362 activin receptor activity, type II 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0016423 tRNA (guanine) methyltransferase activity 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0017002 activin receptor activity 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0035497 cAMP response element binding 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0042301 phosphate ion binding 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0045295 gamma-catenin binding 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/2997 12/18639 0.166666666666667 1.03653653653654 0.597503457782337 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 26/2997 167/18639 0.155688622754491 0.968261674848501 0.604178606976846 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/2997 19/18639 0.157894736842105 0.981981981981982 0.609572719605977 1 GO:0015245 fatty acid transmembrane transporter activity 3/2997 19/18639 0.157894736842105 0.981981981981982 0.609572719605977 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/2997 19/18639 0.157894736842105 0.981981981981982 0.609572719605977 1 GO:0016918 retinal binding 3/2997 19/18639 0.157894736842105 0.981981981981982 0.609572719605977 1 GO:0042834 peptidoglycan binding 3/2997 19/18639 0.157894736842105 0.981981981981982 0.609572719605977 1 GO:0097001 ceramide binding 3/2997 19/18639 0.157894736842105 0.981981981981982 0.609572719605977 1 GO:1990380 K48-linked deubiquitinase activity 3/2997 19/18639 0.157894736842105 0.981981981981982 0.609572719605977 1 GO:0005080 protein kinase C binding 8/2997 52/18639 0.153846153846154 0.956802956802957 0.61249541583228 1 GO:0019843 rRNA binding 10/2997 65/18639 0.153846153846154 0.956802956802957 0.612747624237774 1 GO:0000217 DNA secondary structure binding 6/2997 39/18639 0.153846153846154 0.956802956802957 0.614202201568665 1 GO:0008234 cysteine-type peptidase activity 29/2997 187/18639 0.155080213903743 0.964477846830788 0.615390217097728 1 GO:0072341 modified amino acid binding 14/2997 91/18639 0.153846153846154 0.956802956802957 0.615743216679889 1 GO:0004435 phosphatidylinositol phospholipase C activity 4/2997 26/18639 0.153846153846154 0.956802956802957 0.620548581806553 1 GO:0004529 DNA exonuclease activity 4/2997 26/18639 0.153846153846154 0.956802956802957 0.620548581806553 1 GO:0005227 calcium-activated cation channel activity 4/2997 26/18639 0.153846153846154 0.956802956802957 0.620548581806553 1 GO:0019865 immunoglobulin binding 4/2997 26/18639 0.153846153846154 0.956802956802957 0.620548581806553 1 GO:0030247 polysaccharide binding 4/2997 26/18639 0.153846153846154 0.956802956802957 0.620548581806553 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 20/2997 130/18639 0.153846153846154 0.956802956802957 0.622434048934826 1 GO:0015459 potassium channel regulator activity 9/2997 59/18639 0.152542372881356 0.948694457169033 0.623146793369178 1 GO:0051020 GTPase binding 49/2997 315/18639 0.155555555555556 0.967434100767434 0.624483847456664 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/2997 46/18639 0.152173913043478 0.946402924663794 0.625064718528549 1 GO:0030276 clathrin binding 7/2997 46/18639 0.152173913043478 0.946402924663794 0.625064718528549 1 GO:0005246 calcium channel regulator activity 8/2997 53/18639 0.150943396226415 0.938750070825543 0.634945523340315 1 GO:0005262 calcium channel activity 20/2997 131/18639 0.152671755725191 0.949499117438049 0.636740921128734 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/2997 40/18639 0.15 0.932882882882883 0.639895386749719 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 6/2997 40/18639 0.15 0.932882882882883 0.639895386749719 1 GO:0002161 aminoacyl-tRNA editing activity 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0004535 poly(A)-specific ribonuclease activity 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0004993 G protein-coupled serotonin receptor activity 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0005172 vascular endothelial growth factor receptor binding 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0031432 titin binding 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0035325 Toll-like receptor binding 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0043560 insulin receptor substrate binding 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0051011 microtubule minus-end binding 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0070123 transforming growth factor beta receptor activity, type III 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0070700 BMP receptor binding 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0140333 glycerophospholipid flippase activity 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:1901338 catecholamine binding 2/2997 13/18639 0.153846153846154 0.956802956802957 0.64262889475528 1 GO:0016741 transferase activity, transferring one-carbon groups 33/2997 215/18639 0.153488372093023 0.954577833647601 0.643833430040117 1 GO:0001614 purinergic nucleotide receptor activity 3/2997 20/18639 0.15 0.932882882882883 0.645696183899612 1 GO:0016502 nucleotide receptor activity 3/2997 20/18639 0.15 0.932882882882883 0.645696183899612 1 GO:0030742 GTP-dependent protein binding 3/2997 20/18639 0.15 0.932882882882883 0.645696183899612 1 GO:0140939 histone H4 methyltransferase activity 3/2997 20/18639 0.15 0.932882882882883 0.645696183899612 1 GO:0140359 ABC-type transporter activity 7/2997 47/18639 0.148936170212766 0.926266692224139 0.648545720715001 1 GO:0008395 steroid hydroxylase activity 4/2997 27/18639 0.148148148148148 0.921365810254699 0.651402976925824 1 GO:0008173 RNA methyltransferase activity 10/2997 67/18639 0.149253731343284 0.928241674510331 0.652519763966227 1 GO:0042054 histone methyltransferase activity 10/2997 67/18639 0.149253731343284 0.928241674510331 0.652519763966227 1 GO:0017069 snRNA binding 8/2997 54/18639 0.148148148148148 0.921365810254699 0.656652113294125 1 GO:0008175 tRNA methyltransferase activity 5/2997 34/18639 0.147058823529412 0.914591061649885 0.657883308849741 1 GO:0140101 catalytic activity, acting on a tRNA 21/2997 139/18639 0.151079136690647 0.939594270529522 0.658055389931805 1 GO:0008081 phosphoric diester hydrolase activity 13/2997 87/18639 0.149425287356322 0.929308618963791 0.658375681093494 1 GO:0015103 inorganic anion transmembrane transporter activity 25/2997 165/18639 0.151515151515152 0.942305942305942 0.660048694538305 1 GO:0003714 transcription corepressor activity 31/2997 204/18639 0.151960784313725 0.945077430371548 0.664094979266151 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 7/2997 48/18639 0.145833333333333 0.906969469469469 0.671134085520887 1 GO:0032266 phosphatidylinositol-3-phosphate binding 7/2997 48/18639 0.145833333333333 0.906969469469469 0.671134085520887 1 GO:0036121 double-stranded DNA helicase activity 7/2997 48/18639 0.145833333333333 0.906969469469469 0.671134085520887 1 GO:0005548 phospholipid transporter activity 10/2997 68/18639 0.147058823529412 0.914591061649885 0.671520041001394 1 GO:0051087 protein-folding chaperone binding 20/2997 134/18639 0.149253731343284 0.928241674510331 0.678023526649378 1 GO:0051082 unfolded protein binding 18/2997 121/18639 0.148760330578512 0.925173106991289 0.678597794224996 1 GO:0015631 tubulin binding 59/2997 385/18639 0.153246753246753 0.953075153075153 0.679194162348401 1 GO:0005123 death receptor binding 3/2997 21/18639 0.142857142857143 0.888459888459888 0.679379167804227 1 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2997 21/18639 0.142857142857143 0.888459888459888 0.679379167804227 1 GO:0009975 cyclase activity 3/2997 21/18639 0.142857142857143 0.888459888459888 0.679379167804227 1 GO:0010314 phosphatidylinositol-5-phosphate binding 3/2997 21/18639 0.142857142857143 0.888459888459888 0.679379167804227 1 GO:0015125 bile acid transmembrane transporter activity 3/2997 21/18639 0.142857142857143 0.888459888459888 0.679379167804227 1 GO:0019200 carbohydrate kinase activity 3/2997 21/18639 0.142857142857143 0.888459888459888 0.679379167804227 1 GO:0035613 RNA stem-loop binding 3/2997 21/18639 0.142857142857143 0.888459888459888 0.679379167804227 1 GO:0061891 calcium ion sensor activity 3/2997 21/18639 0.142857142857143 0.888459888459888 0.679379167804227 1 GO:0046875 ephrin receptor binding 4/2997 28/18639 0.142857142857143 0.888459888459888 0.680532256263824 1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2997 28/18639 0.142857142857143 0.888459888459888 0.680532256263824 1 GO:0004705 JUN kinase activity 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0008174 mRNA methyltransferase activity 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0008494 translation activator activity 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0015926 glucosidase activity 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0019992 diacylglycerol binding 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0034236 protein kinase A catalytic subunit binding 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0046030 inositol trisphosphate phosphatase activity 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0070742 C2H2 zinc finger domain binding 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0098821 BMP receptor activity 2/2997 14/18639 0.142857142857143 0.888459888459888 0.683654093264591 1 GO:0008307 structural constituent of muscle 6/2997 42/18639 0.142857142857143 0.888459888459888 0.688087516949174 1 GO:0001222 transcription corepressor binding 7/2997 49/18639 0.142857142857143 0.888459888459888 0.692797475907118 1 GO:0005254 chloride channel activity 12/2997 83/18639 0.144578313253012 0.899164224465429 0.701415366667176 1 GO:0004722 protein serine/threonine phosphatase activity 15/2997 103/18639 0.145631067961165 0.905711536779498 0.702965866350362 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 10/2997 70/18639 0.142857142857143 0.888459888459888 0.707630066844687 1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/2997 29/18639 0.137931034482759 0.857823340581961 0.707910366782604 1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 4/2997 29/18639 0.137931034482759 0.857823340581961 0.707910366782604 1 GO:0097472 cyclin-dependent protein kinase activity 4/2997 29/18639 0.137931034482759 0.857823340581961 0.707910366782604 1 GO:0055106 ubiquitin-protein transferase regulator activity 5/2997 36/18639 0.138888888888889 0.86378044711378 0.708408594676875 1 GO:0004712 protein serine/threonine/tyrosine kinase activity 6/2997 43/18639 0.13953488372093 0.867798030588728 0.710521086204206 1 GO:0008200 ion channel inhibitor activity 6/2997 43/18639 0.13953488372093 0.867798030588728 0.710521086204206 1 GO:0004407 histone deacetylase activity 3/2997 22/18639 0.136363636363636 0.848075348075348 0.710620925217936 1 GO:0015377 chloride:monoatomic cation symporter activity 3/2997 22/18639 0.136363636363636 0.848075348075348 0.710620925217936 1 GO:0016881 acid-amino acid ligase activity 3/2997 22/18639 0.136363636363636 0.848075348075348 0.710620925217936 1 GO:0033558 protein lysine deacetylase activity 3/2997 22/18639 0.136363636363636 0.848075348075348 0.710620925217936 1 GO:0140035 ubiquitin-like protein reader activity 3/2997 22/18639 0.136363636363636 0.848075348075348 0.710620925217936 1 GO:0000774 adenyl-nucleotide exchange factor activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0004089 carbonate dehydratase activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0004467 long-chain fatty acid-CoA ligase activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0008020 G protein-coupled photoreceptor activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0008242 omega peptidase activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0034483 heparan sulfate sulfotransferase activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0047372 monoacylglycerol lipase activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0140161 monocarboxylate:sodium symporter activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0140776 protein-containing complex destabilizing activity 2/2997 15/18639 0.133333333333333 0.829229229229229 0.720730536993275 1 GO:0004536 DNA nuclease activity 9/2997 64/18639 0.140625 0.874577702702703 0.720777236641745 1 GO:0019213 deacetylase activity 5/2997 37/18639 0.135135135135135 0.840435029624219 0.73161458916348 1 GO:0030280 structural constituent of skin epidermis 5/2997 37/18639 0.135135135135135 0.840435029624219 0.73161458916348 1 GO:0001046 core promoter sequence-specific DNA binding 6/2997 44/18639 0.136363636363636 0.848075348075348 0.731823434011978 1 GO:0016248 channel inhibitor activity 6/2997 44/18639 0.136363636363636 0.848075348075348 0.731823434011978 1 GO:0043014 alpha-tubulin binding 6/2997 44/18639 0.136363636363636 0.848075348075348 0.731823434011978 1 GO:0030544 Hsp70 protein binding 7/2997 51/18639 0.137254901960784 0.85361832420656 0.733267262187651 1 GO:0022839 monoatomic ion-gated channel activity 4/2997 30/18639 0.133333333333333 0.829229229229229 0.733536280491489 1 GO:0035925 mRNA 3'-UTR AU-rich region binding 4/2997 30/18639 0.133333333333333 0.829229229229229 0.733536280491489 1 GO:0003887 DNA-directed DNA polymerase activity 3/2997 23/18639 0.130434782608696 0.811202506854681 0.739460103049047 1 GO:0005212 structural constituent of eye lens 3/2997 23/18639 0.130434782608696 0.811202506854681 0.739460103049047 1 GO:0070577 lysine-acetylated histone binding 3/2997 23/18639 0.130434782608696 0.811202506854681 0.739460103049047 1 GO:0008201 heparin binding 25/2997 172/18639 0.145348837209302 0.903956281863259 0.740464741577076 1 GO:0141110 transporter inhibitor activity 6/2997 45/18639 0.133333333333333 0.829229229229229 0.751991084191538 1 GO:0031593 polyubiquitin modification-dependent protein binding 8/2997 59/18639 0.135593220338983 0.84328396192803 0.753084174409814 1 GO:0042887 amide transmembrane transporter activity 5/2997 38/18639 0.131578947368421 0.818318318318318 0.753448484892562 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0004707 MAP kinase activity 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0004708 MAP kinase kinase activity 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0008296 3'-5'-DNA exonuclease activity 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0015378 sodium:chloride symporter activity 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0017070 U6 snRNA binding 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0019841 retinol binding 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0022841 potassium ion leak channel activity 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0140327 flippase activity 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0140328 floppase activity 2/2997 16/18639 0.125 0.777402402402402 0.754067000257012 1 GO:0047499 calcium-independent phospholipase A2 activity 4/2997 31/18639 0.129032258064516 0.802479899254093 0.757429991926097 1 GO:0005216 monoatomic ion channel activity 67/2997 448/18639 0.149553571428571 0.930106445731446 0.762318637469776 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 3/2997 24/18639 0.125 0.777402402402402 0.765965949606502 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 3/2997 24/18639 0.125 0.777402402402402 0.765965949606502 1 GO:0004622 lysophospholipase activity 3/2997 24/18639 0.125 0.777402402402402 0.765965949606502 1 GO:0005315 phosphate transmembrane transporter activity 3/2997 24/18639 0.125 0.777402402402402 0.765965949606502 1 GO:0070300 phosphatidic acid binding 3/2997 24/18639 0.125 0.777402402402402 0.765965949606502 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/2997 24/18639 0.125 0.777402402402402 0.765965949606502 1 GO:0140033 acetylation-dependent protein binding 3/2997 24/18639 0.125 0.777402402402402 0.765965949606502 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 8/2997 60/18639 0.133333333333333 0.829229229229229 0.769858652407699 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/2997 60/18639 0.133333333333333 0.829229229229229 0.769858652407699 1 GO:0005544 calcium-dependent phospholipid binding 7/2997 53/18639 0.132075471698113 0.82140631197235 0.76987484804985 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 7/2997 53/18639 0.132075471698113 0.82140631197235 0.76987484804985 1 GO:0034212 protein N-acetyltransferase activity 7/2997 53/18639 0.132075471698113 0.82140631197235 0.76987484804985 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 6/2997 46/18639 0.130434782608696 0.811202506854681 0.771030039040986 1 GO:0003684 damaged DNA binding 10/2997 74/18639 0.135135135135135 0.840435029624219 0.771914817094747 1 GO:0005539 glycosaminoglycan binding 35/2997 242/18639 0.144628099173554 0.899473854019308 0.779161198339138 1 GO:0031369 translation initiation factor binding 4/2997 32/18639 0.125 0.777402402402402 0.779628795485231 1 GO:0043425 bHLH transcription factor binding 4/2997 32/18639 0.125 0.777402402402402 0.779628795485231 1 GO:0004252 serine-type endopeptidase activity 25/2997 176/18639 0.142045454545455 0.883411820911821 0.780671259665487 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:0009881 photoreceptor activity 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:0030169 low-density lipoprotein particle binding 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:0031489 myosin V binding 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:0032183 SUMO binding 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:0036041 long-chain fatty acid binding 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:1990226 histone methyltransferase binding 2/2997 17/18639 0.117647058823529 0.731672849319908 0.78390721921984 1 GO:0003777 microtubule motor activity 9/2997 68/18639 0.132352941176471 0.823131955484897 0.785732946734446 1 GO:0140223 general transcription initiation factor activity 9/2997 68/18639 0.132352941176471 0.823131955484897 0.785732946734446 1 GO:0061733 protein-lysine-acetyltransferase activity 6/2997 47/18639 0.127659574468085 0.793942879049262 0.788954573430154 1 GO:0061749 forked DNA-dependent helicase activity 6/2997 47/18639 0.127659574468085 0.793942879049262 0.788954573430154 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 6/2997 47/18639 0.127659574468085 0.793942879049262 0.788954573430154 1 GO:0016298 lipase activity 18/2997 130/18639 0.138461538461538 0.861122661122661 0.789999103457079 1 GO:0005251 delayed rectifier potassium channel activity 3/2997 25/18639 0.12 0.746306306306306 0.790230711401185 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/2997 25/18639 0.12 0.746306306306306 0.790230711401185 1 GO:0015645 fatty acid ligase activity 3/2997 25/18639 0.12 0.746306306306306 0.790230711401185 1 GO:0017025 TBP-class protein binding 3/2997 25/18639 0.12 0.746306306306306 0.790230711401185 1 GO:0120515 fatty acid-CoA ligase activity 3/2997 25/18639 0.12 0.746306306306306 0.790230711401185 1 GO:0016922 nuclear receptor binding 19/2997 137/18639 0.138686131386861 0.86251945376033 0.792578064470586 1 GO:0004177 aminopeptidase activity 5/2997 40/18639 0.125 0.777402402402402 0.793073092748917 1 GO:0015144 carbohydrate transmembrane transporter activity 5/2997 40/18639 0.125 0.777402402402402 0.793073092748917 1 GO:1990782 protein tyrosine kinase binding 16/2997 117/18639 0.136752136752137 0.850491517158184 0.796162982911347 1 GO:0002039 p53 binding 9/2997 69/18639 0.130434782608696 0.811202506854681 0.800108422288036 1 GO:0016279 protein-lysine N-methyltransferase activity 9/2997 69/18639 0.130434782608696 0.811202506854681 0.800108422288036 1 GO:0030165 PDZ domain binding 11/2997 83/18639 0.132530120481928 0.824233872426644 0.800459575406496 1 GO:0031072 heat shock protein binding 18/2997 131/18639 0.137404580152672 0.854549205694244 0.800510248192418 1 GO:0009378 four-way junction helicase activity 6/2997 48/18639 0.125 0.777402402402402 0.805786071702907 1 GO:0043138 3'-5' DNA helicase activity 6/2997 48/18639 0.125 0.777402402402402 0.805786071702907 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/2997 18/18639 0.111111111111111 0.691024357691024 0.810513258882087 1 GO:0004706 JUN kinase kinase kinase activity 2/2997 18/18639 0.111111111111111 0.691024357691024 0.810513258882087 1 GO:0008308 voltage-gated monoatomic anion channel activity 2/2997 18/18639 0.111111111111111 0.691024357691024 0.810513258882087 1 GO:0015373 monoatomic anion:sodium symporter activity 2/2997 18/18639 0.111111111111111 0.691024357691024 0.810513258882087 1 GO:0031690 adrenergic receptor binding 2/2997 18/18639 0.111111111111111 0.691024357691024 0.810513258882087 1 GO:0032393 MHC class I receptor activity 2/2997 18/18639 0.111111111111111 0.691024357691024 0.810513258882087 1 GO:0001530 lipopolysaccharide binding 5/2997 41/18639 0.121951219512195 0.758441368197466 0.810925340312477 1 GO:0016877 ligase activity, forming carbon-sulfur bonds 5/2997 41/18639 0.121951219512195 0.758441368197466 0.810925340312477 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 3/2997 26/18639 0.115384615384615 0.717602217602218 0.812363163087441 1 GO:0070006 metalloaminopeptidase activity 3/2997 26/18639 0.115384615384615 0.717602217602218 0.812363163087441 1 GO:0016278 lysine N-methyltransferase activity 9/2997 70/18639 0.128571428571429 0.7996138996139 0.813752769812464 1 GO:0008170 N-methyltransferase activity 13/2997 98/18639 0.13265306122449 0.824998467855611 0.813998786027963 1 GO:0005200 structural constituent of cytoskeleton 15/2997 112/18639 0.133928571428571 0.832931145431145 0.816092199801338 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/2997 34/18639 0.117647058823529 0.731672849319908 0.819157294803194 1 GO:0090482 vitamin transmembrane transporter activity 4/2997 34/18639 0.117647058823529 0.731672849319908 0.819157294803194 1 GO:0000182 rDNA binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0003796 lysozyme activity 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0005131 growth hormone receptor binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0005522 profilin binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0015279 store-operated calcium channel activity 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0015643 toxic substance binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0031720 haptoglobin binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0032052 bile acid binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0032356 oxidized DNA binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0035256 G protein-coupled glutamate receptor binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0035374 chondroitin sulfate binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0042975 peroxisome proliferator activated receptor binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0070097 delta-catenin binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:0099122 RNA polymerase II C-terminal domain binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:1905394 retromer complex binding 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:1990757 ubiquitin ligase activator activity 1/2997 10/18639 0.1 0.621921921921922 0.826820786651376 1 GO:1901681 sulfur compound binding 39/2997 275/18639 0.141818181818182 0.881998361998362 0.827424300554094 1 GO:0019894 kinesin binding 5/2997 42/18639 0.119047619047619 0.74038324038324 0.827525046172382 1 GO:0031492 nucleosomal DNA binding 5/2997 42/18639 0.119047619047619 0.74038324038324 0.827525046172382 1 GO:0042056 chemoattractant activity 5/2997 42/18639 0.119047619047619 0.74038324038324 0.827525046172382 1 GO:0003735 structural constituent of ribosome 24/2997 175/18639 0.137142857142857 0.852921492921493 0.830915822075363 1 GO:0016405 CoA-ligase activity 3/2997 27/18639 0.111111111111111 0.691024357691024 0.832483186357643 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/2997 27/18639 0.111111111111111 0.691024357691024 0.832483186357643 1 GO:0008574 plus-end-directed microtubule motor activity 2/2997 19/18639 0.105263157894737 0.654654654654655 0.834153322326335 1 GO:0022840 leak channel activity 2/2997 19/18639 0.105263157894737 0.654654654654655 0.834153322326335 1 GO:0022842 narrow pore channel activity 2/2997 19/18639 0.105263157894737 0.654654654654655 0.834153322326335 1 GO:0030506 ankyrin binding 2/2997 19/18639 0.105263157894737 0.654654654654655 0.834153322326335 1 GO:0031420 alkali metal ion binding 2/2997 19/18639 0.105263157894737 0.654654654654655 0.834153322326335 1 GO:0046624 sphingolipid transporter activity 2/2997 19/18639 0.105263157894737 0.654654654654655 0.834153322326335 1 GO:0070003 threonine-type peptidase activity 2/2997 19/18639 0.105263157894737 0.654654654654655 0.834153322326335 1 GO:0099589 serotonin receptor activity 2/2997 19/18639 0.105263157894737 0.654654654654655 0.834153322326335 1 GO:0004623 phospholipase A2 activity 4/2997 35/18639 0.114285714285714 0.710767910767911 0.836619194352953 1 GO:0010485 histone H4 acetyltransferase activity 4/2997 35/18639 0.114285714285714 0.710767910767911 0.836619194352953 1 GO:0034061 DNA polymerase activity 4/2997 35/18639 0.114285714285714 0.710767910767911 0.836619194352953 1 GO:0005245 voltage-gated calcium channel activity 5/2997 43/18639 0.116279069767442 0.723165025490607 0.842920304062932 1 GO:0008408 3'-5' exonuclease activity 7/2997 58/18639 0.120689655172414 0.750595423009216 0.844954417947235 1 GO:0001221 transcription coregulator binding 15/2997 115/18639 0.130434782608696 0.811202506854681 0.84577988073334 1 GO:0101005 deubiquitinase activity 15/2997 115/18639 0.130434782608696 0.811202506854681 0.84577988073334 1 GO:0046873 metal ion transmembrane transporter activity 65/2997 450/18639 0.144444444444444 0.898331664998332 0.846492159365111 1 GO:0005048 signal sequence binding 6/2997 51/18639 0.117647058823529 0.731672849319908 0.850020110067403 1 GO:0036408 histone H3K14 acetyltransferase activity 3/2997 28/18639 0.107142857142857 0.666344916344916 0.850717297968901 1 GO:0046625 sphingolipid binding 3/2997 28/18639 0.107142857142857 0.666344916344916 0.850717297968901 1 GO:0046966 nuclear thyroid hormone receptor binding 3/2997 28/18639 0.107142857142857 0.666344916344916 0.850717297968901 1 GO:0051119 sugar transmembrane transporter activity 3/2997 28/18639 0.107142857142857 0.666344916344916 0.850717297968901 1 GO:0141052 histone H3 demethylase activity 3/2997 28/18639 0.107142857142857 0.666344916344916 0.850717297968901 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 4/2997 36/18639 0.111111111111111 0.691024357691024 0.852645519312463 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0001851 complement component C3b binding 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0004016 adenylate cyclase activity 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0008046 axon guidance receptor activity 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0008432 JUN kinase binding 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0008503 benzodiazepine receptor activity 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0016594 glycine binding 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0019215 intermediate filament binding 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0019864 IgG binding 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0031731 CCR6 chemokine receptor binding 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0070697 activin receptor binding 1/2997 11/18639 0.0909090909090909 0.565383565383565 0.854681546885733 1 GO:0004620 phospholipase activity 14/2997 109/18639 0.128440366972477 0.798798798798799 0.854924499120017 1 GO:0000339 RNA cap binding 2/2997 20/18639 0.1 0.621921921921922 0.855093004373748 1 GO:0005326 neurotransmitter transmembrane transporter activity 2/2997 20/18639 0.1 0.621921921921922 0.855093004373748 1 GO:0016408 C-acyltransferase activity 2/2997 20/18639 0.1 0.621921921921922 0.855093004373748 1 GO:0016505 peptidase activator activity involved in apoptotic process 2/2997 20/18639 0.1 0.621921921921922 0.855093004373748 1 GO:0001786 phosphatidylserine binding 7/2997 59/18639 0.11864406779661 0.737873466687026 0.857321566115734 1 GO:0004879 nuclear receptor activity 7/2997 59/18639 0.11864406779661 0.737873466687026 0.857321566115734 1 GO:0033192 calmodulin-dependent protein phosphatase activity 10/2997 81/18639 0.123456790123457 0.767804841878916 0.858936836295902 1 GO:0140791 histone H2AXS140 phosphatase activity 10/2997 81/18639 0.123456790123457 0.767804841878916 0.858936836295902 1 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 10/2997 81/18639 0.123456790123457 0.767804841878916 0.858936836295902 1 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 10/2997 81/18639 0.123456790123457 0.767804841878916 0.858936836295902 1 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 10/2997 81/18639 0.123456790123457 0.767804841878916 0.858936836295902 1 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 10/2997 81/18639 0.123456790123457 0.767804841878916 0.858936836295902 1 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 10/2997 81/18639 0.123456790123457 0.767804841878916 0.858936836295902 1 GO:1990439 MAP kinase serine/threonine phosphatase activity 10/2997 81/18639 0.123456790123457 0.767804841878916 0.858936836295902 1 GO:0005261 monoatomic cation channel activity 48/2997 341/18639 0.140762463343109 0.875432617368101 0.86309154933142 1 GO:0016407 acetyltransferase activity 12/2997 96/18639 0.125 0.777402402402402 0.865448528346644 1 GO:0010484 histone H3 acetyltransferase activity 3/2997 29/18639 0.103448275862069 0.643367505436471 0.86719502079809 1 GO:0098531 ligand-modulated transcription factor activity 7/2997 60/18639 0.116666666666667 0.725575575575576 0.868873271699814 1 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 10/2997 82/18639 0.121951219512195 0.758441368197466 0.868881780991272 1 GO:0033549 MAP kinase phosphatase activity 10/2997 82/18639 0.121951219512195 0.758441368197466 0.868881780991272 1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/2997 21/18639 0.0952380952380952 0.592306592306592 0.873589197696856 1 GO:0005248 voltage-gated sodium channel activity 2/2997 21/18639 0.0952380952380952 0.592306592306592 0.873589197696856 1 GO:1904047 S-adenosyl-L-methionine binding 2/2997 21/18639 0.0952380952380952 0.592306592306592 0.873589197696856 1 GO:0051018 protein kinase A binding 6/2997 53/18639 0.113207547169811 0.704062553119157 0.874660867364456 1 GO:0030145 manganese ion binding 8/2997 68/18639 0.117647058823529 0.731672849319908 0.875049425993637 1 GO:0140597 protein carrier chaperone 25/2997 188/18639 0.132978723404255 0.827023832342981 0.87523442024239 1 GO:0000340 RNA 7-methylguanosine cap binding 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0003720 telomerase activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0004032 aldose reductase (NADPH) activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0004126 cytidine deaminase activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0004859 phospholipase inhibitor activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0005049 nuclear export signal receptor activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0005165 neurotrophin receptor binding 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0005247 voltage-gated chloride channel activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0008504 monoamine transmembrane transporter activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0015166 polyol transmembrane transporter activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0015368 calcium:monoatomic cation antiporter activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0035197 siRNA binding 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0070410 co-SMAD binding 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0070679 inositol 1,4,5 trisphosphate binding 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0097677 STAT family protein binding 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:1990817 poly(A) RNA polymerase activity 1/2997 12/18639 0.0833333333333333 0.518268268268268 0.878061373167859 1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 10/2997 83/18639 0.120481927710843 0.749303520387858 0.878254685865899 1 GO:0000146 microfilament motor activity 4/2997 38/18639 0.105263157894737 0.654654654654655 0.880712105699337 1 GO:0032452 histone demethylase activity 3/2997 30/18639 0.1 0.621921921921922 0.882045991943267 1 GO:0033612 receptor serine/threonine kinase binding 3/2997 30/18639 0.1 0.621921921921922 0.882045991943267 1 GO:0043995 histone H4K5 acetyltransferase activity 3/2997 30/18639 0.1 0.621921921921922 0.882045991943267 1 GO:0043996 histone H4K8 acetyltransferase activity 3/2997 30/18639 0.1 0.621921921921922 0.882045991943267 1 GO:0043997 histone H4K12 acetyltransferase activity 3/2997 30/18639 0.1 0.621921921921922 0.882045991943267 1 GO:0051721 protein phosphatase 2A binding 3/2997 30/18639 0.1 0.621921921921922 0.882045991943267 1 GO:0008080 N-acetyltransferase activity 8/2997 69/18639 0.115942028985507 0.721068894981938 0.88487775434847 1 GO:0019783 ubiquitin-like protein peptidase activity 16/2997 127/18639 0.125984251968504 0.783523681161476 0.88626464452012 1 GO:0017018 myosin phosphatase activity 10/2997 84/18639 0.119047619047619 0.74038324038324 0.887075261673989 1 GO:0008649 rRNA methyltransferase activity 2/2997 22/18639 0.0909090909090909 0.565383565383565 0.889886024944748 1 GO:0050321 tau-protein kinase activity 2/2997 22/18639 0.0909090909090909 0.565383565383565 0.889886024944748 1 GO:0140938 histone H3 methyltransferase activity 5/2997 47/18639 0.106382978723404 0.661619065874385 0.89354388355282 1 GO:0005184 neuropeptide hormone activity 3/2997 31/18639 0.0967741935483871 0.60185992444057 0.895397706230821 1 GO:0016878 acid-thiol ligase activity 3/2997 31/18639 0.0967741935483871 0.60185992444057 0.895397706230821 1 GO:0140457 protein demethylase activity 3/2997 31/18639 0.0967741935483871 0.60185992444057 0.895397706230821 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0003964 RNA-directed DNA polymerase activity 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0008253 5'-nucleotidase activity 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0009982 pseudouridine synthase activity 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0030955 potassium ion binding 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0032396 inhibitory MHC class I receptor activity 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0045159 myosin II binding 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0046974 histone H3K9 methyltransferase activity 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0071837 HMG box domain binding 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0089720 caspase binding 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0140666 annealing activity 1/2997 13/18639 0.0769230769230769 0.478401478401478 0.897680746368908 1 GO:0008528 G protein-coupled peptide receptor activity 15/2997 122/18639 0.122950819672131 0.764658100723675 0.900707255211211 1 GO:0004843 cysteine-type deubiquitinase activity 13/2997 108/18639 0.12037037037037 0.748609720831943 0.903438793059405 1 GO:0038187 pattern recognition receptor activity 5/2997 48/18639 0.104166666666667 0.647835335335335 0.903748280279554 1 GO:0140693 molecular condensate scaffold activity 5/2997 48/18639 0.104166666666667 0.647835335335335 0.903748280279554 1 GO:0061791 GTPase motor activity 4/2997 40/18639 0.1 0.621921921921922 0.904009929512916 1 GO:1990606 membrane scission GTPase motor activity 4/2997 40/18639 0.1 0.621921921921922 0.904009929512916 1 GO:0017134 fibroblast growth factor binding 2/2997 23/18639 0.0869565217391304 0.540801671236454 0.904212303220529 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/2997 23/18639 0.0869565217391304 0.540801671236454 0.904212303220529 1 GO:0140102 catalytic activity, acting on a rRNA 2/2997 23/18639 0.0869565217391304 0.540801671236454 0.904212303220529 1 GO:0015370 solute:sodium symporter activity 9/2997 79/18639 0.113924050632911 0.708518645227506 0.906478467702347 1 GO:0047498 calcium-dependent phospholipase A2 activity 3/2997 32/18639 0.09375 0.583051801801802 0.907373800445883 1 GO:0160041 neuropeptide activity 3/2997 32/18639 0.09375 0.583051801801802 0.907373800445883 1 GO:0016410 N-acyltransferase activity 11/2997 94/18639 0.117021276595745 0.727780972461824 0.907622218507465 1 GO:0019787 ubiquitin-like protein transferase activity 67/2997 479/18639 0.139874739039666 0.869911665318763 0.909369249305554 1 GO:0035091 phosphatidylinositol binding 38/2997 284/18639 0.133802816901408 0.83214905045891 0.910636168777875 1 GO:0003823 antigen binding 22/2997 174/18639 0.126436781609195 0.786338062200131 0.91387493972968 1 GO:0001727 lipid kinase activity 4/2997 41/18639 0.0975609756097561 0.606753094557973 0.914073128345396 1 GO:0004812 aminoacyl-tRNA ligase activity 4/2997 41/18639 0.0975609756097561 0.606753094557973 0.914073128345396 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 4/2997 41/18639 0.0975609756097561 0.606753094557973 0.914073128345396 1 GO:0005344 oxygen carrier activity 1/2997 14/18639 0.0714285714285714 0.444229944229944 0.91414433506924 1 GO:0008331 high voltage-gated calcium channel activity 1/2997 14/18639 0.0714285714285714 0.444229944229944 0.91414433506924 1 GO:0008392 arachidonate epoxygenase activity 1/2997 14/18639 0.0714285714285714 0.444229944229944 0.91414433506924 1 GO:0019763 immunoglobulin receptor activity 1/2997 14/18639 0.0714285714285714 0.444229944229944 0.91414433506924 1 GO:0030983 mismatched DNA binding 1/2997 14/18639 0.0714285714285714 0.444229944229944 0.91414433506924 1 GO:0032454 histone H3K9 demethylase activity 1/2997 14/18639 0.0714285714285714 0.444229944229944 0.91414433506924 1 GO:0061783 peptidoglycan muralytic activity 1/2997 14/18639 0.0714285714285714 0.444229944229944 0.91414433506924 1 GO:1901612 cardiolipin binding 1/2997 14/18639 0.0714285714285714 0.444229944229944 0.91414433506924 1 GO:1990825 sequence-specific mRNA binding 1/2997 14/18639 0.0714285714285714 0.444229944229944 0.91414433506924 1 GO:0003774 cytoskeletal motor activity 19/2997 153/18639 0.124183006535948 0.772321340948792 0.915022224160469 1 GO:0005540 hyaluronic acid binding 2/2997 24/18639 0.0833333333333333 0.518268268268268 0.916780153549077 1 GO:0015149 hexose transmembrane transporter activity 2/2997 24/18639 0.0833333333333333 0.518268268268268 0.916780153549077 1 GO:0030552 cAMP binding 2/2997 24/18639 0.0833333333333333 0.518268268268268 0.916780153549077 1 GO:0043998 histone H2A acetyltransferase activity 2/2997 24/18639 0.0833333333333333 0.518268268268268 0.916780153549077 1 GO:0055056 D-glucose transmembrane transporter activity 2/2997 24/18639 0.0833333333333333 0.518268268268268 0.916780153549077 1 GO:0140612 DNA damage sensor activity 2/2997 24/18639 0.0833333333333333 0.518268268268268 0.916780153549077 1 GO:0005179 hormone activity 16/2997 132/18639 0.121212121212121 0.753844753844754 0.917528339252398 1 GO:0071889 14-3-3 protein binding 3/2997 33/18639 0.0909090909090909 0.565383565383565 0.918092792021368 1 GO:0016755 aminoacyltransferase activity 69/2997 496/18639 0.139112903225806 0.865173641383319 0.92042298187356 1 GO:0030971 receptor tyrosine kinase binding 9/2997 81/18639 0.111111111111111 0.691024357691024 0.920703330156906 1 GO:0017116 single-stranded DNA helicase activity 6/2997 58/18639 0.103448275862069 0.643367505436471 0.921782896756623 1 GO:0004402 histone acetyltransferase activity 4/2997 42/18639 0.0952380952380952 0.592306592306592 0.923183452784661 1 GO:0004520 DNA endonuclease activity 4/2997 42/18639 0.0952380952380952 0.592306592306592 0.923183452784661 1 GO:0051879 Hsp90 protein binding 4/2997 42/18639 0.0952380952380952 0.592306592306592 0.923183452784661 1 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 47/2997 349/18639 0.134670487106017 0.837545281671356 0.924013162253319 1 GO:0019825 oxygen binding 3/2997 34/18639 0.0882352941176471 0.548754636989931 0.927667194977966 1 GO:0001848 complement binding 2/2997 25/18639 0.08 0.497537537537538 0.927784452866285 1 GO:0004709 MAP kinase kinase kinase activity 2/2997 25/18639 0.08 0.497537537537538 0.927784452866285 1 GO:0042974 nuclear retinoic acid receptor binding 2/2997 25/18639 0.08 0.497537537537538 0.927784452866285 1 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/2997 15/18639 0.0666666666666667 0.414614614614615 0.92795960636038 1 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/2997 15/18639 0.0666666666666667 0.414614614614615 0.92795960636038 1 GO:0008252 nucleotidase activity 1/2997 15/18639 0.0666666666666667 0.414614614614615 0.92795960636038 1 GO:0010181 FMN binding 1/2997 15/18639 0.0666666666666667 0.414614614614615 0.92795960636038 1 GO:0015250 water channel activity 1/2997 15/18639 0.0666666666666667 0.414614614614615 0.92795960636038 1 GO:0042809 nuclear vitamin D receptor binding 1/2997 15/18639 0.0666666666666667 0.414614614614615 0.92795960636038 1 GO:0050700 CARD domain binding 1/2997 15/18639 0.0666666666666667 0.414614614614615 0.92795960636038 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/2997 15/18639 0.0666666666666667 0.414614614614615 0.92795960636038 1 GO:0005272 sodium channel activity 5/2997 51/18639 0.0980392156862745 0.609727374433257 0.929405463838932 1 GO:0001653 peptide receptor activity 15/2997 128/18639 0.1171875 0.728814752252252 0.933998281492862 1 GO:0005112 Notch binding 2/2997 26/18639 0.0769230769230769 0.478401478401478 0.937402893681188 1 GO:0008066 glutamate receptor activity 2/2997 26/18639 0.0769230769230769 0.478401478401478 0.937402893681188 1 GO:0008157 protein phosphatase 1 binding 2/2997 26/18639 0.0769230769230769 0.478401478401478 0.937402893681188 1 GO:0015145 monosaccharide transmembrane transporter activity 2/2997 26/18639 0.0769230769230769 0.478401478401478 0.937402893681188 1 GO:0052742 phosphatidylinositol kinase activity 2/2997 26/18639 0.0769230769230769 0.478401478401478 0.937402893681188 1 GO:0120014 phospholipid transfer activity 2/2997 26/18639 0.0769230769230769 0.478401478401478 0.937402893681188 1 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/2997 16/18639 0.0625 0.388701201201201 0.939552446767271 1 GO:0008391 arachidonate monooxygenase activity 1/2997 16/18639 0.0625 0.388701201201201 0.939552446767271 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/2997 16/18639 0.0625 0.388701201201201 0.939552446767271 1 GO:0030275 LRR domain binding 1/2997 16/18639 0.0625 0.388701201201201 0.939552446767271 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2997 16/18639 0.0625 0.388701201201201 0.939552446767271 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2997 16/18639 0.0625 0.388701201201201 0.939552446767271 1 GO:0003724 RNA helicase activity 8/2997 77/18639 0.103896103896104 0.646152646152646 0.942540042030735 1 GO:0016887 ATP hydrolysis activity 56/2997 417/18639 0.134292565947242 0.835194907137353 0.942989806627186 1 GO:0000993 RNA polymerase II complex binding 3/2997 36/18639 0.0833333333333333 0.518268268268268 0.943799074647842 1 GO:0008266 poly(U) RNA binding 2/2997 27/18639 0.0740740740740741 0.460682905127349 0.945796470267072 1 GO:0005267 potassium channel activity 14/2997 124/18639 0.112903225806452 0.702169911847331 0.948391208166084 1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/2997 17/18639 0.0588235294117647 0.365836424659954 0.949280273488986 1 GO:0016018 cyclosporin A binding 1/2997 17/18639 0.0588235294117647 0.365836424659954 0.949280273488986 1 GO:0045236 CXCR chemokine receptor binding 1/2997 17/18639 0.0588235294117647 0.365836424659954 0.949280273488986 1 GO:0046965 nuclear retinoid X receptor binding 1/2997 17/18639 0.0588235294117647 0.365836424659954 0.949280273488986 1 GO:0061659 ubiquitin-like protein ligase activity 49/2997 372/18639 0.131720430107527 0.819198230488553 0.949599636380634 1 GO:0140297 DNA-binding transcription factor binding 66/2997 488/18639 0.135245901639344 0.841123910796042 0.949828288084091 1 GO:0003712 transcription coregulator activity 67/2997 495/18639 0.135353535353535 0.841793308459975 0.950281544133897 1 GO:0030551 cyclic nucleotide binding 3/2997 37/18639 0.0810810810810811 0.504261017774531 0.950547586961938 1 GO:0008186 ATP-dependent activity, acting on RNA 8/2997 79/18639 0.10126582278481 0.629794351313339 0.952191820304454 1 GO:0004842 ubiquitin-protein transferase activity 60/2997 449/18639 0.133630289532294 0.831076064929072 0.9533137387695 1 GO:0140104 molecular carrier activity 31/2997 249/18639 0.124497991967871 0.774280304400786 0.954957713888893 1 GO:0000049 tRNA binding 8/2997 80/18639 0.1 0.621921921921922 0.956453090738885 1 GO:0099095 ligand-gated monoatomic anion channel activity 4/2997 47/18639 0.0851063829787234 0.529295252699508 0.956931836758112 1 GO:0003746 translation elongation factor activity 1/2997 18/18639 0.0555555555555556 0.345512178845512 0.957443039054097 1 GO:0004970 glutamate-gated receptor activity 1/2997 18/18639 0.0555555555555556 0.345512178845512 0.957443039054097 1 GO:0005372 water transmembrane transporter activity 1/2997 18/18639 0.0555555555555556 0.345512178845512 0.957443039054097 1 GO:0015280 ligand-gated sodium channel activity 1/2997 18/18639 0.0555555555555556 0.345512178845512 0.957443039054097 1 GO:0022851 GABA-gated chloride ion channel activity 1/2997 18/18639 0.0555555555555556 0.345512178845512 0.957443039054097 1 GO:1901611 phosphatidylglycerol binding 1/2997 18/18639 0.0555555555555556 0.345512178845512 0.957443039054097 1 GO:0003727 single-stranded RNA binding 9/2997 89/18639 0.101123595505618 0.628909808685089 0.960559561992657 1 GO:0099094 ligand-gated monoatomic cation channel activity 15/2997 136/18639 0.110294117647059 0.685943296237414 0.96325192225648 1 GO:0004890 GABA-A receptor activity 1/2997 19/18639 0.0526315789473684 0.327327327327327 0.964292467761195 1 GO:0005229 intracellularly calcium-gated chloride channel activity 1/2997 19/18639 0.0526315789473684 0.327327327327327 0.964292467761195 1 GO:0042800 histone H3K4 methyltransferase activity 1/2997 19/18639 0.0526315789473684 0.327327327327327 0.964292467761195 1 GO:0140036 ubiquitin-modified protein reader activity 1/2997 19/18639 0.0526315789473684 0.327327327327327 0.964292467761195 1 GO:0141147 intracellularly calcium-gated channel activity 1/2997 19/18639 0.0526315789473684 0.327327327327327 0.964292467761195 1 GO:0005249 voltage-gated potassium channel activity 10/2997 98/18639 0.102040816326531 0.634614206042778 0.964349154757926 1 GO:0003678 DNA helicase activity 7/2997 74/18639 0.0945945945945946 0.588304520736953 0.964360937560678 1 GO:0031491 nucleosome binding 7/2997 74/18639 0.0945945945945946 0.588304520736953 0.964360937560678 1 GO:0035064 methylated histone binding 7/2997 74/18639 0.0945945945945946 0.588304520736953 0.964360937560678 1 GO:0008187 poly-pyrimidine tract binding 2/2997 30/18639 0.0666666666666667 0.414614614614615 0.965004940583365 1 GO:0032451 demethylase activity 3/2997 40/18639 0.075 0.466441441441441 0.966523434885426 1 GO:0140662 ATP-dependent protein folding chaperone 3/2997 40/18639 0.075 0.466441441441441 0.966523434885426 1 GO:0017147 Wnt-protein binding 2/2997 31/18639 0.0645161290322581 0.401239949627046 0.96980543950423 1 GO:0015464 acetylcholine receptor activity 1/2997 20/18639 0.05 0.310960960960961 0.970039807939482 1 GO:0140664 ATP-dependent DNA damage sensor activity 1/2997 20/18639 0.05 0.310960960960961 0.970039807939482 1 GO:0070888 E-box binding 5/2997 59/18639 0.0847457627118644 0.527052476205019 0.970622613000132 1 GO:0140828 metal cation:monoatomic cation antiporter activity 3/2997 41/18639 0.0731707317073171 0.455064820918479 0.970664248559639 1 GO:0140034 methylation-dependent protein binding 7/2997 76/18639 0.0921052631578947 0.572822822822823 0.97088576809507 1 GO:1901981 phosphatidylinositol phosphate binding 21/2997 185/18639 0.113513513513514 0.705965424884344 0.972934610653134 1 GO:0051059 NF-kappaB binding 2/2997 32/18639 0.0625 0.388701201201201 0.973967548774786 1 GO:0043175 RNA polymerase core enzyme binding 3/2997 42/18639 0.0714285714285714 0.444229944229944 0.974316617465407 1 GO:0001846 opsonin binding 1/2997 21/18639 0.0476190476190476 0.296153296153296 0.974862338451613 1 GO:0051428 peptide hormone receptor binding 1/2997 21/18639 0.0476190476190476 0.296153296153296 0.974862338451613 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/2997 86/18639 0.0930232558139535 0.578532020392486 0.975588121380264 1 GO:0061630 ubiquitin protein ligase activity 44/2997 353/18639 0.124645892351275 0.775200129307778 0.976696599001712 1 GO:0019239 deaminase activity 2/2997 33/18639 0.0606060606060606 0.376922376922377 0.977572371791136 1 GO:0042923 neuropeptide binding 2/2997 33/18639 0.0606060606060606 0.376922376922377 0.977572371791136 1 GO:0141003 histone H2AX kinase activity 44/2997 354/18639 0.124293785310734 0.773010298434027 0.977895185652556 1 GO:0140658 ATP-dependent chromatin remodeler activity 17/2997 158/18639 0.107594936708861 0.669156498270422 0.978240224377395 1 GO:0022843 voltage-gated monoatomic cation channel activity 15/2997 143/18639 0.104895104895105 0.652365652365652 0.978754244973943 1 GO:0005243 gap junction channel activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0031683 G-protein beta/gamma-subunit complex binding 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0032931 histone H3K56 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0043992 histone H3K9 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0043993 histone H3K18 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0043994 histone H3K23 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0043999 histone H2AK5 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0044012 histone H2AK9 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0044014 histone H2BK5 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0044015 histone H2BK12 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0044016 histone H3K4 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0044017 histone H3K27 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0044018 histone H3K36 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0046972 histone H4K16 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0140908 histone H3K122 acetyltransferase activity 1/2997 22/18639 0.0454545454545455 0.282691782691783 0.978908829570988 1 GO:0140296 general transcription initiation factor binding 4/2997 53/18639 0.0754716981132075 0.469375035412771 0.979228266319473 1 GO:0000510 H3-H4 histone complex chaperone activity 16/2997 151/18639 0.105960264900662 0.658990115943758 0.979284830156219 1 GO:0140584 chromatin extrusion motor activity 16/2997 151/18639 0.105960264900662 0.658990115943758 0.979284830156219 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 16/2997 151/18639 0.105960264900662 0.658990115943758 0.979284830156219 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 16/2997 151/18639 0.105960264900662 0.658990115943758 0.979284830156219 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/2997 44/18639 0.0681818181818182 0.424037674037674 0.980365421656049 1 GO:0003713 transcription coactivator activity 30/2997 256/18639 0.1171875 0.728814752252252 0.980509876992194 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/2997 34/18639 0.0588235294117647 0.365836424659954 0.980691445341959 1 GO:0051427 hormone receptor binding 2/2997 34/18639 0.0588235294117647 0.365836424659954 0.980691445341959 1 GO:0015616 DNA translocase activity 16/2997 152/18639 0.105263157894737 0.654654654654655 0.980860949012455 1 GO:0140674 ATP-dependent histone chaperone activity 16/2997 152/18639 0.105263157894737 0.654654654654655 0.980860949012455 1 GO:0022832 voltage-gated channel activity 19/2997 175/18639 0.108571428571429 0.675229515229515 0.981059967625328 1 GO:0140996 histone H3 kinase activity 44/2997 357/18639 0.123249299719888 0.766514413573237 0.9811714261576 1 GO:0016917 GABA receptor activity 1/2997 23/18639 0.0434782608695652 0.270400835618227 0.982304126223281 1 GO:0044013 histone H2B acetyltransferase activity 1/2997 23/18639 0.0434782608695652 0.270400835618227 0.982304126223281 1 GO:0061775 cohesin loader activity 16/2997 153/18639 0.104575163398693 0.650375866062141 0.982327662629595 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 6/2997 73/18639 0.0821917808219178 0.511168702949525 0.983826316593846 1 GO:0035173 histone kinase activity 44/2997 360/18639 0.122222222222222 0.760126793460127 0.984009869287453 1 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/2997 24/18639 0.0416666666666667 0.259134134134134 0.985152994600421 1 GO:0008135 translation factor activity, RNA binding 7/2997 83/18639 0.0843373493975904 0.5245124642715 0.986031315414781 1 GO:0180051 translation factor activity 7/2997 84/18639 0.0833333333333333 0.518268268268268 0.987462181435281 1 GO:0005244 voltage-gated monoatomic ion channel activity 18/2997 173/18639 0.104046242774566 0.647086392751133 0.987724938900236 1 GO:0140030 modification-dependent protein binding 18/2997 173/18639 0.104046242774566 0.647086392751133 0.987724938900236 1 GO:0022829 wide pore channel activity 2/2997 37/18639 0.0540540540540541 0.336174011849688 0.98772611181136 1 GO:0008188 neuropeptide receptor activity 3/2997 48/18639 0.0625 0.388701201201201 0.988634408254019 1 GO:0042826 histone deacetylase binding 12/2997 127/18639 0.094488188976378 0.587642760871107 0.989023239199048 1 GO:1902936 phosphatidylinositol bisphosphate binding 10/2997 111/18639 0.0900900900900901 0.560290019749479 0.989411262724333 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/2997 26/18639 0.0384615384615385 0.239200739200739 0.989548968779002 1 GO:0008143 poly(A) binding 1/2997 26/18639 0.0384615384615385 0.239200739200739 0.989548968779002 1 GO:0051139 metal cation:proton antiporter activity 1/2997 26/18639 0.0384615384615385 0.239200739200739 0.989548968779002 1 GO:0003689 DNA clamp loader activity 16/2997 160/18639 0.1 0.621921921921922 0.990048188591057 1 GO:0001098 basal transcription machinery binding 4/2997 60/18639 0.0666666666666667 0.414614614614615 0.99147014307798 1 GO:0001099 basal RNA polymerase II transcription machinery binding 4/2997 60/18639 0.0666666666666667 0.414614614614615 0.99147014307798 1 GO:0015276 ligand-gated monoatomic ion channel activity 19/2997 186/18639 0.102150537634409 0.63529658690949 0.991930077235235 1 GO:0030331 nuclear estrogen receptor binding 2/2997 40/18639 0.05 0.310960960960961 0.992237956931064 1 GO:0071855 neuropeptide receptor binding 2/2997 40/18639 0.05 0.310960960960961 0.992237956931064 1 GO:0004679 AMP-activated protein kinase activity 27/2997 248/18639 0.108870967741935 0.677092414995641 0.992452358445374 1 GO:0008013 beta-catenin binding 9/2997 106/18639 0.0849056603773585 0.528046914839368 0.99248652740669 1 GO:0003743 translation initiation factor activity 3/2997 51/18639 0.0588235294117647 0.365836424659954 0.992513859693302 1 GO:0005242 inward rectifier potassium channel activity 1/2997 28/18639 0.0357142857142857 0.222114972114972 0.992643664754854 1 GO:0140713 histone chaperone activity 16/2997 164/18639 0.0975609756097561 0.606753094557973 0.992918691409987 1 GO:0022834 ligand-gated channel activity 19/2997 188/18639 0.101063829787234 0.628538112580666 0.99313501651318 1 GO:0008227 G protein-coupled amine receptor activity 2/2997 41/18639 0.0487804878048781 0.303376547278986 0.993344300950112 1 GO:0004674 protein serine/threonine kinase activity 52/2997 433/18639 0.120092378752887 0.746880830021708 0.993378004254355 1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 26/2997 243/18639 0.106995884773663 0.665430862961727 0.993724770610798 1 GO:0022836 gated channel activity 36/2997 318/18639 0.113207547169811 0.704062553119157 0.993832380827815 1 GO:0022824 transmitter-gated monoatomic ion channel activity 4/2997 63/18639 0.0634920634920635 0.394871061537728 0.994238674219989 1 GO:0022835 transmitter-gated channel activity 4/2997 63/18639 0.0634920634920635 0.394871061537728 0.994238674219989 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/2997 53/18639 0.0566037735849057 0.352031276559578 0.994350980794451 1 GO:0004676 3-phosphoinositide-dependent protein kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0004711 ribosomal protein S6 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0035175 histone H3S10 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0035979 histone H2AXS139 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0044022 histone H3S28 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0044023 histone H4S1 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0044024 histone H2AS1 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0044025 histone H2BS14 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0072354 histone H3T3 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0072371 histone H2AS121 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0072518 Rho-dependent protein serine/threonine kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0140823 histone H2BS36 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0140855 histone H3S57 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0140995 histone H2A kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0140997 histone H4 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0140998 histone H2B kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:1990244 histone H2AT120 kinase activity 26/2997 245/18639 0.106122448979592 0.659998774284488 0.994583971892364 1 GO:0004677 DNA-dependent protein kinase activity 26/2997 246/18639 0.105691056910569 0.657315852437804 0.994971471323119 1 GO:0140857 histone H3T45 kinase activity 26/2997 246/18639 0.105691056910569 0.657315852437804 0.994971471323119 1 GO:0015079 potassium ion transmembrane transporter activity 15/2997 160/18639 0.09375 0.583051801801802 0.995032057386243 1 GO:0035402 histone H3T11 kinase activity 26/2997 247/18639 0.105263157894737 0.654654654654655 0.995333132615763 1 GO:0035403 histone H3T6 kinase activity 26/2997 247/18639 0.105263157894737 0.654654654654655 0.995333132615763 1 GO:0004386 helicase activity 14/2997 155/18639 0.0903225806451613 0.561735929477865 0.996287101424101 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 3/2997 56/18639 0.0535714285714286 0.333172458172458 0.99631334811479 1 GO:0070717 poly-purine tract binding 1/2997 32/18639 0.03125 0.194350600600601 0.996355713616313 1 GO:0140142 nucleocytoplasmic carrier activity 1/2997 32/18639 0.03125 0.194350600600601 0.996355713616313 1 GO:0015081 sodium ion transmembrane transporter activity 15/2997 164/18639 0.0914634146341463 0.568831026148099 0.996550059739618 1 GO:1990841 promoter-specific chromatin binding 4/2997 68/18639 0.0588235294117647 0.365836424659954 0.997042039961517 1 GO:0030594 neurotransmitter receptor activity 7/2997 97/18639 0.0721649484536082 0.448809634376645 0.997109210338106 1 GO:0061980 regulatory RNA binding 3/2997 58/18639 0.0517241379310345 0.321683752718235 0.997233769688305 1 GO:0042393 histone binding 25/2997 247/18639 0.101214574898785 0.629475629475629 0.997421032840817 1 GO:0030332 cyclin binding 1/2997 34/18639 0.0294117647058824 0.182918212329977 0.997435155100059 1 GO:0070063 RNA polymerase binding 3/2997 59/18639 0.0508474576271186 0.316231485723011 0.997605675109091 1 GO:0140566 histone reader activity 1/2997 35/18639 0.0285714285714286 0.177691977691978 0.997848315012186 1 GO:0140097 catalytic activity, acting on DNA 36/2997 336/18639 0.107142857142857 0.666344916344916 0.998186084753427 1 GO:0008094 ATP-dependent activity, acting on DNA 19/2997 210/18639 0.0904761904761905 0.562691262691263 0.998972844522326 1 GO:0106310 protein serine kinase activity 38/2997 361/18639 0.105263157894737 0.654654654654655 0.999102910283303 1 GO:0140463 chromatin-protein adaptor activity 2/2997 54/18639 0.037037037037037 0.230341452563675 0.999131515795204 1 GO:0035198 miRNA binding 1/2997 42/18639 0.0238095238095238 0.148076648076648 0.999370962951935 1 GO:0098960 postsynaptic neurotransmitter receptor activity 3/2997 69/18639 0.0434782608695652 0.270400835618227 0.999448758235276 1 GO:0036002 pre-mRNA binding 2/2997 59/18639 0.0338983050847458 0.210820990482007 0.999608982114417 1 GO:0031490 chromatin DNA binding 8/2997 128/18639 0.0625 0.388701201201201 0.999783285919886 1 GO:0046982 protein heterodimerization activity 36/2997 369/18639 0.0975609756097561 0.606753094557973 0.999851457619483 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 7/2997 122/18639 0.0573770491803279 0.356840447004382 0.999867110747502 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 21/2997 268/18639 0.0783582089552239 0.487326879117924 0.999980785831432 1 GO:0001217 DNA-binding transcription repressor activity 22/2997 278/18639 0.079136690647482 0.492168427420226 0.999983189092237 1 GO:0140767 enzyme-substrate adaptor activity 7/2997 139/18639 0.0503597122302158 0.313198090176507 0.99998582230971 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 40/2997 484/18639 0.0826446280991736 0.513985059439605 0.999999899037963 1 GO:0005549 odorant binding 2/2997 111/18639 0.018018018018018 0.112058003949896 0.999999925396274 1 GO:0001216 DNA-binding transcription activator activity 40/2997 491/18639 0.0814663951120163 0.506657370201158 0.999999948546011 1 GO:0003730 mRNA 3'-UTR binding 12/2997 262/18639 0.0458015267175573 0.284849735231415 0.999999998764075 1 GO:0030371 translation repressor activity 7/2997 329/18639 0.0212765957446809 0.132323813174877 1 1 GO:0045182 translation regulator activity 10/2997 356/18639 0.0280898876404494 0.174697169079192 1 1