category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	44/887	205/9376	2.26878213765227	ISG15/B2M/HLA-A/CCND3/JUN/EIF2AK2/IRF7/HLA-DPA1/OAS2/HLA-DQA1/NFKB1/OAS1/SAP30/ICAM1/CD247/TLR2/LYN/TNFAIP3/STAT1/HLA-C/GADD45B/STAT2/OAS3/CXCL10/RUNX3/IRF9/PLCG2/RB1/HLA-DRB1/ENTPD1/BLNK/APAF1/HLA-E/HLA-DMB/HLA-DMA/IKBKB/MAP2K6/NFKB2/CDKN1B/POLK/MAP3K14/CD58/CD3E/NFKBIE	5.93710624868777
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	38/887	173/9376	2.32183563482806	DNAJB1/MX1/CCND3/EIF2AK2/MX2/IRF7/HLA-DPA1/OAS2/HLA-DQA1/RSAD2/NFKB1/OAS1/ICAM1/IFIH1/STAT1/STAT2/CIITA/OAS3/CXCL10/TLR3/IRF9/TLR7/PYCARD/JAK2/TNFSF10/HLA-DRB1/PML/CALCOCO2/ADAR/APAF1/HLA-DMB/HLA-DMA/IKBKB/CCL2/KPNA1/NXT1/IL1A/CASP1	5.67224495523034
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	23/887	82/9376	2.9648857480683	HSP90AA1/B2M/HLA-A/HSPA1B/HSPA1A/CD74/KLRC1/HLA-DPA1/HLA-DQA1/KLRC3/CREB1/KLRC2/KLRD1/HLA-C/CIITA/IFI30/HLA-DRB1/HSP90AB1/HLA-E/HLA-DMB/KIR2DL4/PSME2/HLA-DMA	5.77646406582218
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	38/887	180/9376	2.23154202680696	B2M/HLA-A/CD74/BST2/EIF2AK2/IRF7/HLA-DPA1/C3/OAS2/HLA-DQA1/NFKB1/OAS1/IFIH1/TLR2/ZC3HAV1/STAT1/HLA-C/STAT2/SP100/OAS3/BIRC3/TLR3/IRF9/JAK2/POU2F1/HLA-DRB1/PML/PPP1CB/NECTIN2/APAF1/HLA-E/HLA-DMB/HLA-DMA/IKBKB/EIF4EBP1/CGAS/CCL2/SRSF7	5.39268669665993
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	44/887	224/9376	2.07634079561926	FOS/B2M/HLA-A/ZFP36/CCND3/JUN/HLA-DPA1/HLA-DQA1/NFKB1/ICAM1/EGR2/CREB1/IL2RB/HLA-C/TSPO/ATM/EGR1/PPP3CA/RB1/SPI1/DLG1/HLA-DRB1/ATR/TGFB2/HLA-E/ANAPC16/HLA-DMB/KAT2B/HLA-DMA/IKBKB/TGFBR1/NFKB2/MAP3K1/IL1R2/NFATC3/GPS2/MAP3K14/CDC27/CD3E/MAP3K3/KRAS/RANBP3/ELK4/CDKN2A	5.27029573917375
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	32/887	142/9376	2.38207599599854	FOS/JUNB/JUN/ACP5/NCF1/FOSB/NFKB1/SQSTM1/TYROBP/JUND/CREB1/STAT1/CTSK/STAT2/LCP2/TREM2/FOSL2/IRF9/PLCG2/PPP3CA/FCGR2B/LILRA2/SPI1/TGFB2/BLNK/IKBKB/TGFBR1/MAP2K6/NFKB2/MAP3K14/FCGR2A/IL1A	5.36414294582718
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	41/887	216/9376	2.0064303311203	APOA1/FOS/HSP90AA1/MMP9/HSPA1B/HSPA1A/JUN/HSPD1/IRF7/NCF1/NFKB1/NFE2L2/ICAM1/TANK/TLR2/OLR1/LYN/LY96/RHOA/PPP3CA/PYCARD/CCL3/JAK2/POU2F1/TNFSF10/HSP90AB1/VAV3/APAF1/IKBKB/ATF6/MAP2K6/CAMK2D/CCL2/ROCK2/NFATC3/TLR6/LDLR/CALM2/VAV1/KRAS/CASP1	4.83706626308639
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/887	93/9376	2.61420033700646	FOS/JUN/STAT4/HLA-DPA1/HLA-DQA1/MAML3/NFKB1/CD247/IL2RB/STAT1/RUNX3/PPP3CA/JAK2/HLA-DRB1/HLA-DMB/GATA3/HLA-DMA/IKBKB/NFATC3/CD3E/NFKBIE/ZAP70/MAF	5.05677830430168
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	25/887	109/9376	2.42441794317512	FOS/HSP90AA1/JUN/AHR/HLA-DPA1/HLA-DQA1/IL1RAP/NFKB1/CD247/IL2RB/STAT1/PPP3CA/HIF1A/JAK2/HLA-DRB1/HSP90AB1/HLA-DMB/GATA3/HLA-DMA/IKBKB/TGFBR1/NFATC3/CD3E/NFKBIE/ZAP70	4.83504237397611
Human Diseases	Infectious disease: viral	hsa05162	Measles	29/887	136/9376	2.25399562305193	FOS/HSPA1B/HSPA1A/MX1/CCND3/JUN/EIF2AK2/MX2/IRF7/OAS2/NFKB1/OAS1/IFIH1/TLR2/TNFAIP3/IL2RB/STAT1/STAT2/OAS3/IRF9/TLR7/FCGR2B/CD46/ADAR/APAF1/IKBKB/CDKN1B/CD3E/IL1A	4.76155352393538
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	14/887	44/9376	3.36332889207748	HLA-A/GZMB/HSPD1/HLA-DPA1/HLA-DQA1/HLA-C/CD86/PRF1/ICA1/HLA-DRB1/HLA-E/HLA-DMB/HLA-DMA/IL1A	5.07904801920001
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/887	45/9376	3.28858825003132	HLA-A/KLRC1/GZMB/HLA-DPA1/HLA-DQA1/KLRD1/HLA-C/CD86/PRF1/HLA-DRB1/HLA-E/HLA-DMB/HLA-DMA/IL1A	4.97426602086575
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	29/887	142/9376	2.15875637137368	KLF2/FOS/HSP90AA1/MMP9/MEF2C/DUSP1/MEF2A/JUN/NCF1/NFKB1/SQSTM1/NFE2L2/ICAM1/RHOA/HMOX1/HSP90AB1/BMPR2/PECAM1/MGST2/MAP2K5/IKBKB/CTNNB1/GSTP1/MAP2K6/CCL2/IL1R2/CALM2/KDR/IL1A	4.49739003747444
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	26/887	122/9376	2.25272145933059	FOS/JUN/NCK1/NFKB1/PTPRC/CD247/PPP2R5E/MALT1/IL10/RHOA/PAK1/LCP2/CARD11/PPP3CA/ITK/DLG1/VAV3/IKBKB/PPP2R5C/NFATC3/MAP3K14/VAV1/CD3E/KRAS/NFKBIE/ZAP70	4.50182766915902
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	21/887	91/9376	2.43933743821004	FOS/JUN/CD81/NFKB1/INPP5D/LYN/MALT1/CARD11/PLCG2/PPP3CA/FCGR2B/LILRA2/CD22/VAV3/BLNK/IKBKB/DAPP1/NFATC3/VAV1/KRAS/NFKBIE	4.45976058866542
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	30/887	157/9376	2.01983354756246	HLA-A/CCND3/ZFP36L1/NFKB1/SQSTM1/SERPINE1/IGFBP3/CDK1/HLA-C/GADD45B/ATM/ZFP36L2/PPP3CA/HIPK3/RB1/ATR/PPP1CB/BTRC/TGFB2/NBN/HLA-E/KIR2DL4/EIF4EBP1/TGFBR1/MAP2K6/NFATC3/CALM2/KRAS/IL1A/CDKN2A	4.16539694414868
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	34/887	187/9376	1.92190222404428	NAMPT/HSP90AA1/TXNIP/JUN/IRF7/OAS2/NFKB1/OAS1/RIPK2/TANK/TNFAIP3/STAT1/STAT2/GBP4/RHOA/TRPM2/OAS3/BIRC3/PKN2/IRF9/GABARAP/PYCARD/NLRP1/HSP90AB1/NEK7/GPSM3/CARD8/ATG5/GSDMD/IKBKB/CCL2/CARD6/CAMP/CASP1	4.11614553275384
Human Diseases	Immune disease	hsa05330	Allograft rejection	12/887	39/9376	3.25244991761339	HLA-A/GZMB/HLA-DPA1/HLA-DQA1/HLA-C/IL10/CD86/PRF1/HLA-DRB1/HLA-E/HLA-DMB/HLA-DMA	4.55620177404579
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	22/887	105/9376	2.21476351532721	JUN/NFKB1/EGR2/STAT1/MALT1/IL10/STAT2/RHOA/PAK1/IRF9/PLCG2/PPP3CA/PYCARD/BCL3/IKBKB/NFKB2/NFATC3/MAP3K14/CALM2/KRAS/CLEC7A/CASP1	4.04615280408988
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/887	78/9376	2.43933743821004	FOS/JUN/HLA-DPA1/C3/NCF1/HLA-DQA1/NFKB1/TLR2/STAT1/IL10/JAK2/ITGA4/HLA-DRB1/TGFB2/HLA-DMB/HLA-DMA/FCGR2A/IL1A	4.12604854731812
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	16/887	66/9376	2.5625362987257	JUN/STAT4/HLA-DPA1/HLA-DQA1/NFKB1/TLR2/STAT1/TLR5/IL10/HLA-DRB1/TGFB2/HLA-DMB/GATA3/HLA-DMA/IL1A/MAF	4.1176215073902
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	32/887	181/9376	1.86881100238559	CD74/HSPD1/HLA-DPA1/C3/HLA-DQA1/NFKB1/RIPK2/TLR2/CREB1/STAT1/MALT1/IL10/RHOA/CIITA/PPP3CA/FCGR2B/JAK2/HLA-DRB1/TGFB2/ATP6V0C/APAF1/HLA-DMB/HLA-DMA/CORO1A/CAMK2D/TLR6/FCGR2A/CALM2/CLEC7A/IL1A/PIK3C3/CAMP	3.81511746408424
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	39/887	238/9376	1.73213456746848	FOS/ISG15/MX1/JUN/EIF2AK2/MX2/C3/C1QB/OAS2/NFKB1/OAS1/IFIH1/TLR2/RPL36AL/STAT1/STAT2/RPL28/OAS3/CXCL10/RPL35/RPS24/TLR3/C1QA/IRF9/PLCG2/TLR7/C2/ADAR/C1QC/RPL22L1/RPS15A/FAU/IKBKB/UBA52/RPL36A/CGAS/CCL2/FCGR2A/CASP1	3.69805184424249
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	26/887	138/9376	1.9915363625966	FOS/JUN/FYB1/NFKB1/ELMO1/IL10/RHOA/LCP2/PKN2/PYCARD/SKAP2/GIT2/ITGA4/VAV3/IKBKB/WAS/RHOG/MAP2K6/CCL2/ROCK2/NFATC3/RPS6KA2/FCGR2A/VAV1/ZAP70/CASP1	3.79296112276587
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	20/887	95/9376	2.225360469946	FOS/JUN/ACP5/HLA-DPA1/HLA-DQA1/TNFSF13B/ICAM1/TLR2/CTSK/CD86/CCL3/ATP6V1F/HLA-DRB1/TGFB2/ATP6V0C/HLA-DMB/HLA-DMA/CCL2/ATP6V1A/IL1A	3.88014060584513
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	34/887	201/9376	1.78803838754368	NR4A3/MMP9/MEF2C/GZMB/NFKB1/BMP2K/PBX3/IGFBP3/FUT8/IL2RB/NFKBIZ/FLI1/GADD45B/IGF1/BIRC3/ATM/CD86/SPI1/LYL1/SUPT3H/PML/ETV6/NUPR1/PLAU/MLF1/CDK14/HHEX/CDKN1B/IL1R2/POLK/KMT2A/AFF1/ELK4/MAF	3.65057728593842
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	28/887	156/9376	1.89726245194114	MX1/CD81/IFIT1/EIF2AK2/MX2/IRF7/YWHAZ/OAS2/RSAD2/NFKB1/OAS1/YWHAH/STAT1/STAT2/OAS3/CXCL10/TLR3/IRF9/RB1/BRAF/CLDN4/APAF1/IKBKB/CTNNB1/PIAS1/EIF3E/LDLR/KRAS	3.65288091262712
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	22/887	112/9376	2.07634079561926	HSPA1B/HSPA1A/HLA-DPA1/HLA-DQA1/NFKB1/TLR2/STAT1/LY96/IL10/CIITA/BIRC3/ITGA6/ALOX5/JAK2/HLA-DRB1/TGFB2/HLA-DMB/HLA-DMA/IKBKB/MAP2K6/LAMA4/LDLR	3.7040660366434
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	21/887	105/9376	2.1140924464487	NFKB1/TNFSF13B/ICAM1/LYN/TNFAIP3/LY96/CCL4/MALT1/GADD45B/ERC1/BIRC3/ATM/CARD11/PLCG2/EDA/BLNK/IKBKB/PLAU/NFKB2/MAP3K14/ZAP70	3.71083607577689
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	33/887	196/9376	1.77972068195937	FOS/HLA-A/ZFP36/JUN/EIF2AK2/IRF7/C3/NFKB1/ICAM1/LYN/CREB1/STAT1/HLA-C/STAT2/TLR3/IRF9/PLCG2/PPP3CA/GNB4/RB1/CD86/HIF1A/JAK2/HLA-E/IKBKB/CTNNB1/ATG14/UBA52/MAP2K6/NFATC3/CALM2/KRAS/PIK3C3	3.56586527224848
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	39/887	250/9376	1.64899210822999	DMXL2/ACP5/GLA/CTSC/OSBPL3/AP1S2/GPR155/CTSW/ASAH1/VPS41/CTSK/PSAP/OSBPL1A/DNASE2/BORCS7/TLR3/DEPTOR/TLR7/NPC2/VPS13C/ATP6V1F/DMXL1/CTSH/SLC38A9/VAMP8/ATP6V0C/BORCS5/GNPTG/AP2A2/AGA/SUMF1/GAA/CTSA/ATP6V1A/HEXA/SLC11A1/BLOC1S1/KXD1/MFSD8	3.3619276981501
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	24/887	133/9376	1.90745183138229	HLA-A/KLRC1/GZMB/TYROBP/ICAM1/CD247/KLRC3/KLRC2/KLRD1/HLA-C/PAK1/LCP2/PLCG2/PPP3CA/KLRK1/PRF1/TNFSF10/BRAF/VAV3/HLA-E/KIR2DL4/VAV1/KRAS/ZAP70	3.40692134140818
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/887	75/9376	2.25503194287862	CCND3/SERPINE1/IGFBP3/CDK1/GADD45B/IGF1/ATM/PMAIP1/COP1/ATR/APAF1/RRM2B/ZMAT3/CD82/EI24/CDKN2A	3.52727865582578
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	27/887	158/9376	1.80634481183908	CCNH/CCND3/YWHAZ/CDKN1C/CDK1/YWHAH/PPP2R5E/GADD45B/ATM/RBX1/RB1/PDS5B/ATR/TGFB2/HDAC8/ATRX/ANAPC16/PDS5A/PPP2R5C/TFDP2/CDKN1B/ESCO1/RAD21/CDC27/ORC3/WAPL/CDKN2A	3.30407706905488
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/887	50/9376	2.53691093573844	CXCR4/HLA-DPA1/HLA-DQA1/TNFSF13B/IL10/CD86/ITGA4/HLA-DRB1/HLA-DMB/HLA-DMA/ICOSLG/MAP3K14	3.52212835535623
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	19/887	99/9376	2.02867456982451	HLA-DPA1/C3/C1QB/HLA-DQA1/KRT23/CFH/ICAM1/IL10/C1QA/FCGR2B/SELPLG/C2/HLA-DRB1/C1QC/HLA-DMB/FCAR/HLA-DMA/FCGR2A/CAMP	3.32591391369961
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	44/887	300/9376	1.55033446072905	FOS/MEF2C/HSPA1B/HSPA1A/DUSP1/JUN/NR4A1/PDGFC/TAOK3/IL1RAP/NFKB1/RASA2/PLA2G4A/JUND/RASGRP2/PLA2G4C/RASA1/GADD45B/PAK1/IGF1/NLK/PPP3CA/STK3/HGF/BRAF/NF1/TGFB2/MAP2K5/IKBKB/MAP3K2/TGFBR1/MAP2K6/NFKB2/MAP3K1/NFATC3/MAP3K14/RPS6KA2/PDGFRA/KDR/MAP3K3/KRAS/IL1A/ELK4/DUSP10	3.13154944501117
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/887	250/9376	1.60671025930101	HLA-A/HSPA1B/HSPA1A/CXCR4/EPS15/SMAP2/MVB12B/RAB31/ARAP2/IL2RB/HLA-C/WASHC1/RHOA/RAB11FIP1/GRK3/CHMP5/CAPZA1/GIT2/VPS36/SH3KBP1/PML/WASHC4/SNX6/SMAP1/VPS37B/VPS45/HLA-E/IQSEC2/AP2A2/TGFBR1/SH3GLB1/SNX2/RAB8A/LDLR/PDGFRA/VTA1/PDCD6IP/WWP1	3.14289804086967
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	16/887	78/9376	2.16829994507559	FOS/JUN/C3/C1QB/NFKB1/SERPING1/LY96/IL10/RHOA/C1QA/PYCARD/C2/C1QC/CALM2/IL1A/CASP1	3.34908421280677
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	26/887	155/9376	1.77310979379569	HLA-A/MSR1/HLA-DPA1/C3/NCF1/HLA-DQA1/TLR2/OLR1/HLA-C/SEC22B/FCGR2B/STX7/ATP6V1F/HLA-DRB1/ATP6V0C/HLA-E/HLA-DMB/FCAR/HLA-DMA/CORO1A/ATP6V1A/TLR6/FCGR2A/TUBA3E/CLEC7A/PIK3C3	3.13716379540288
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	20/887	109/9376	1.9395343545401	FOS/JUN/IRF7/NFKB1/TLR2/STAT1/LY96/CCL4/TLR5/CTSK/STAT2/CXCL10/TLR3/IRF9/TLR7/CD86/CCL3/IKBKB/MAP2K6/TLR6	3.18915416488064
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	15/887	73/9376	2.1720127874473	MX1/CXCR4/BST2/MX2/RANBP2/ELL2/MDFIC/BICD1/SUPT4H1/KAT2B/NELFCD/APOBEC3G/SMARCB1/PDCD6IP/CPSF6	3.24938709297999
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	9/887	34/9376	2.79806353206446	PER3/PER1/PRKAG2/CREB1/DBP/RBX1/BHLHE40/BTRC/CRY2	3.39503097696663
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	24/887	142/9376	1.7865569969989	UBE2W/BIRC3/UBA6/RBX1/HERC1/HERC3/COP1/PML/BTRC/UBE2L6/ANAPC16/UBE4B/UBE2K/FANCL/UBA52/UBE2D3/PIAS1/MAP3K1/UBE3A/UBE4A/CDC27/WWP1/UBE3C/UBE2E1	3.05280185688656
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	12/887	54/9376	2.34899160716523	HLA-A/GZMB/HLA-DPA1/HLA-DQA1/HLA-C/IL10/CD86/PRF1/HLA-DRB1/HLA-E/HLA-DMB/HLA-DMA	3.21344417516052
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	17/887	90/9376	1.99664286609044	FOS/JUN/NFKB1/CD247/TLR2/STAT1/PPP3CA/HIF1A/JAK2/IKBKB/MAP2K6/NFATC3/CD3E/MAP3K3/KRAS/NFKBIE/ZAP70	3.07089988977773
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	26/887	160/9376	1.71770011273957	HLA-A/CADM1/NCAM1/HLA-DPA1/SIGLEC1/HLA-DQA1/PTPRC/NFASC/ICAM1/HLA-C/ITGA6/CD86/CD22/SELPLG/ITGA4/F11R/HLA-DRB1/CLDN4/NECTIN2/PECAM1/HLA-E/HLA-DMB/HLA-DMA/ICOSLG/CD58/CD2	2.95972222756181
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	16/887	83/9376	2.03767946645658	IRF7/NFKB1/CCL4/DNASE2/CXCL10/PYCARD/ZBP1/POLR2K/POLR3GL/ADAR/GSDMD/IKBKB/MLKL/CGAS/GSDME/CASP1	3.06932927707054
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	30/887	193/9376	1.64307703091868	CXCR4/NCF1/NFKB1/RASGRP2/LYN/STAT1/CCL8/XCL2/CCL4/ELMO1/STAT2/RHOA/PAK1/XCL1/CXCL10/PLCG2/GRK3/ITK/GNB4/CCL3/JAK2/BRAF/VAV3/IKBKB/WAS/CCL2/ROCK2/VAV1/KRAS/CCL23	2.91788748724581
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	23/887	137/9376	1.77460314847884	FOS/JUN/GZMB/CTSC/NFKB1/CTSW/CTSK/GADD45B/BIRC3/ATM/LMNA/PRF1/PMAIP1/TNFSF10/CTSH/MCL1/APAF1/IKBKB/PARP4/PTPN13/MAP3K14/TUBA3E/KRAS	2.95220314971721
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/887	56/9376	2.26509904976647	HSPA1B/HSPA1A/HSPD1/C3/NFKB1/TLR2/TLR5/SEC22B/PYCARD/APAF1/NFKB2/CASP1	3.06923235793689
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/887	100/9376	1.90268320180383	CD37/HLA-DPA1/HLA-DQA1/ITGA1/CD7/ITGA6/CD59/CD22/ITGA4/HLA-DRB1/CSF3R/HLA-DMB/HLA-DMA/IL7/IL1R2/CD2/CD3E/IL1A	2.93341948222277
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/887	50/9376	2.32550169109357	CD81/ICAM1/KLRB1/TLR2/GYPC/IL10/KLRK1/HGF/TGFB2/PECAM1/CCL2	3.03764322493429
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/887	103/9376	1.84726524446974	FOS/JUN/C3/C1QB/NFKB1/SERPINE1/CD247/TLR2/IL10/C1QA/CCL3/C1QC/TGFB2/IKBKB/TGFBR1/CCL2/TLR6/CD3E	2.79477632381056
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	28/887	184/9376	1.6085486005588	SRGAP1/CXCR4/SSH2/NCK1/SEMA3B/SEMA3A/WNT4/RASA1/RHOA/PAK1/PLCG2/PPP3CA/EPHB2/ABLIM3/WNT5A/PLXNC1/BMPR2/SRGAP2/SRGAP3/LIMK2/DPYSL2/SEMA4C/SEMA4D/SEMA4A/CAMK2D/ROCK2/NFATC3/KRAS	2.69474920846917
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	30/887	204/9376	1.55447974003581	LUM/MMP9/DCN/WNT4/TLR2/WNT6/RHOA/PAK1/VTN/IGF1/PLCG2/ESR1/HCLS1/HGF/HIF1A/FZD1/WNT5A/PLAUR/BRAF/PPP1CB/TGFB2/VAV3/CTNNB1/PLAU/CAMK2D/ROCK2/VAV1/KDR/KRAS/IQGAP1	2.58814094964093
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/887	98/9376	1.83365161171571	MARCKS/NCF1/PTPRC/PLA2G4A/PLPP3/PLA2G4C/INPP5D/LYN/PAK1/PLCG2/FCGR2B/SCIN/VAV3/LIMK2/WAS/FCGR2A/VAV1	2.68157303108485
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/887	33/9376	2.5625362987257	STX11/SEC22B/STX7/VAMP8/STX2/SNAP23/STX6/VAMP2	2.90645157789721
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	35/887	248/9376	1.49179910535695	FOS/HSP90AA1/RHOB/JUN/NFKB1/PTPRC/RIPK2/TLR2/LY96/VPS41/ELMO1/DYNLRB1/TLR5/RHOA/PAK1/BIRC3/PYCARD/RHOH/TNFSF10/HSP90AB1/PIK3C2A/PFN1/GSDMD/IKBKB/CTNNB1/MLKL/RHOG/MAP2K6/ROCK2/DYNLT1/KPNA1/TLR6/TUBA3E/PIK3C3/CASP1	2.53714296798193
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	30/887	205/9376	1.54689691203564	HLA-A/CCND3/JUN/EIF2AK2/IRF7/YWHAZ/C3/NFKB1/RASA2/CDK1/YWHAH/LYN/EGR2/CREB1/HLA-C/RHOA/SP100/IRF9/RB1/PMAIP1/SCIN/DLG1/HDAC8/HLA-E/KAT2B/NFKB2/CDKN1B/UBE3A/KRAS/CDKN2A	2.55913523486624
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	25/887	163/9376	1.62123653868766	FOS/MMP9/JUN/STAT4/IRF7/YWHAZ/NFKB1/IFIH1/TLR2/EGR2/CREB1/STAT1/STAT2/TLR3/RB1/JAK2/BRAF/TGFB2/APAF1/IKBKB/TGFBR1/MAP2K6/MAP3K1/NFATC3/KRAS	2.58624366126925
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/887	157/9376	1.61586683804996	C1QB/ATP8A1/MERTK/CREB1/VPS41/ELMO1/IL10/VPS8/PTGER4/C1QA/ALOX5/HIF1A/JAK2/SGK1/C1QC/PECAM1/SIGLEC10/CD47/GAS6/AXL/CAMK2D/NFATC3/ATP11A/CASP1	2.51543975126856
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	25/887	170/9376	1.55447974003581	WNT4/NFE2L2/GADD45B/WNT6/HMOX1/PLCG2/DPF3/RB1/HGF/FZD1/WNT5A/BRAF/ARID2/APC/TGFB2/MGST2/ARID1B/CTNNB1/GSTP1/TGFBR1/POLK/BRD7/SMARCB1/KRAS/CDKN2A	2.35827169783474
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/887	88/9376	1.80178333504151	CLU/C3/C1QB/SERPING1/CFH/SERPINE1/TFPI/VTN/C1QA/CD59/CD46/PLAUR/C2/C1QC/PLAU	2.44262298394245
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	30/887	214/9376	1.48184049984722	FOS/B2M/HLA-A/CXCR4/JUN/BST2/NFKB1/AP1S2/CD247/CDK1/TLR2/HLA-C/PAK1/ATM/PLCG2/PPP3CA/RBX1/GNB4/ATR/BTRC/LIMK2/HLA-E/IKBKB/MAP2K6/CGAS/NFATC3/APOBEC3G/CALM2/CD3E/KRAS	2.30480519924075
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/887	106/9376	1.69526281083151	HSP90AA1/MMP9/PDGFC/NFKB1/CREB1/IGF1/RB1/HSP90AB1/BRAF/IKBKB/CTNNB1/PLAU/GSTP1/CDKN1B/IL1R2/PDGFRA/KRAS	2.32691889812437
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/887	59/9376	1.97076414499455	DPYD/CMPK2/NUDT2/ENTPD1/CMPK1/NT5C3A/DCK/RRM2B/TK2/ENPP1/CDA	2.41780274752348
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	43/887	333/9376	1.36495458254196	ISG15/HLA-A/MX1/CCND3/EIF2AK2/MX2/MAML3/WNT4/NFKB1/ITGA1/CREB1/STAT1/PPP2R5E/HLA-C/STAT2/WNT6/VTN/PTGER4/ATM/TLR3/IRF9/ITGA6/RB1/ITGA4/FZD1/WNT5A/ATP6V1F/DLG1/ATR/APC/COL4A6/ATP6V0C/HLA-E/IKBKB/CTNNB1/PPP2R5C/EIF4EBP1/CDKN1B/ATP6V1A/UBE3A/LAMA4/PATJ/KRAS	2.19191573282235
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/887	99/9376	1.7083575324838	FOS/JUN/PDGFC/PLA2G4A/PLPP3/PLA2G4C/SLC44A1/HIF1A/LYPLA1/CHPT1/WAS/EIF4EBP1/RALGDS/PDGFRA/DGKZ/KRAS	2.29026384268808
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/887	227/9376	1.44354330043854	FOS/JUN/AHR/NCF1/NFKB1/NFE2L2/HMOX1/UQCR10/HGF/HIF1A/BRAF/MGST2/AKR1A1/NDUFA5/IKBKB/ATP5MC2/COX6B1/UQCRB/NDUFA7/COX8A/NDUFS8/ATP5PD/UQCR11/MAP3K14/NDUFA4/PRKD3/NDUFS7/KRAS/COX5B/NDUFB10/NDUFS6	2.18666029861637
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	18/887	116/9376	1.64024413948606	MMP9/THY1/CXCR4/NCF1/ICAM1/RHOA/PLCG2/ITK/CTNND1/RHOH/ITGA4/F11R/CLDN4/PECAM1/VAV3/CTNNB1/ROCK2/VAV1	2.24278836494214
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	20/887	133/9376	1.58954319281857	KLF2/DEPP1/PRKAG2/SGK3/IL10/GADD45B/IGF1/NLK/ATM/GABARAP/SGK1/TNFSF10/BRAF/TGFB2/IKBKB/TGFBR1/CDKN1B/SETD7/KRAS/HOMER2	2.21337068903811
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/887	69/9376	1.83834125778148	PLA2G4A/PLA2G4C/INPP5D/LYN/LCP2/PLCG2/ALOX5/VAV3/ALOX5AP/MAP2K6/VAV1/KRAS	2.25922616745994
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/887	77/9376	1.7846234937554	NFKB1/STAT1/GADD45B/RB1/ARHGEF6/BRAF/TGFB2/IKBKB/TGFBR1/RALGDS/POLK/KRAS/CDKN2A	2.23464082140988
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/887	85/9376	1.74101730884011	CMPK2/LACC1/NUDT16/ENTPD1/CMPK1/NT5C3A/DCK/RRM2B/TK2/AK3/GMPR/ENPP1/AK5/CDA	2.21832802875091
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/887	70/9376	1.81207923981317	HLA-A/HLA-DPA1/HLA-DQA1/ICAM1/HLA-C/EIF4G3/CD86/PRF1/HLA-DRB1/HLA-E/HLA-DMB/HLA-DMA	2.20437301256829
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/887	78/9376	1.76174370537392	BTG2/HSPD1/XRN1/PAN3/NUDT16/CNOT6L/DHX36/PARN/CNOT10/CNOT4/PATL1/ZCCHC7/TENT4B	2.18363771103974
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/887	87/9376	1.70099392242999	FOS/JUN/GADD45B/RHOA/PMAIP1/BRAF/APC/TGFB2/APPL1/CTNNB1/TGFBR1/RALGDS/POLK/KRAS	2.12328640410889
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	20/887	138/9376	1.53195104815123	UQCR10/ATP6V1F/ATP6V0C/ATP5MG/NDUFA5/ATP5MC2/COX6B1/UQCRB/NDUFA7/COX8A/ATP6V1A/NDUFS8/ATP5PD/UQCR11/NDUFA4/NDUFS7/COX5B/NDUFB10/PPA2/NDUFS6	2.03489223488323
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/887	80/9376	1.71770011273957	PDGFC/IGF1/PLCG2/HGF/JAK2/BRAF/NF1/GAS6/AXL/EIF4EBP1/PDGFRA/KDR/KRAS	2.08381486492091
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	12/887	72/9376	1.76174370537392	ISG15/IRF7/NFKB1/TANK/IFIH1/AZI2/CXCL10/ADAR/ATG5/RNF125/IKBKB/MAP3K1	2.09729466842749
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	22/887	157/9376	1.48121126821247	CCND3/YWHAZ/WNT4/SERPINE1/YWHAH/WNT6/BIRC3/STK3/FZD1/WNT5A/DLG1/BMPR2/PPP1CB/APC/BTRC/TGFB2/NKD1/CTNNB1/TGFBR1/PATJ/CRB2/RASSF1	1.96545402030851
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/887	115/9376	1.56259006911426	FOS/MEF2C/MEF2A/NR4A2/JUND/CREB1/OXSR1/GNA13/RHOA/EGR1/BGLAP/SGK1/BRAF/GATA3/PDE4D/PDE4B/STK39	1.96214555598904
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	28/887	212/9376	1.39609878539065	SIPA1L1/FYB1/PDGFC/DOCK4/RASGRP2/SKAP1/RHOA/IGF1/LCP2/EVL/HGF/CTNND1/BRAF/LPAR1/VAV3/PFN1/CNR1/CTNNB1/APBB1IP/MAP2K6/LPAR5/RALGDS/CALM2/VAV1/PDGFRA/KDR/PRKD3/KRAS	1.88559354246217
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	23/887	168/9376	1.44714661512858	HSP90AA1/FTH1/STAT4/EIF2AK2/SQSTM1/PLA2G4A/PLA2G4C/TNFAIP3/STAT1/STAT2/BIRC3/TLR3/IRF9/PYCARD/CHMP5/ZBP1/JAK2/TNFSF10/HSP90AB1/MLKL/CAMK2D/IL1A/CASP1	1.89034518055153
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/887	101/9376	1.56987062855102	JUN/NFKB1/SERPINE1/ICAM1/STAT1/PLCG2/EGR1/JAK2/COL4A6/TGFB2/TGFBR1/CDKN1B/CCL2/KRAS/IL1A	1.86122630923561
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/887	76/9376	1.6690203524595	GADD45B/IGF1/CAMK1D/PLCG2/RB1/BRAF/CAMK2D/POLK/CALM2/PDGFRA/KRAS/CDKN2A	1.89288327070403
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/887	37/9376	1.9998171790731	GADD45B/BRAF/CCDC6/CTNNB1/POLK/NCOA4/KRAS	1.96965630356113
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/887	120/9376	1.49748214956783	JUN/NFKB1/RIPK2/RHOA/PLCG2/IRAK3/BRAF/ARHGDIB/MAP2K5/IKBKB/CAMK2D/MAP3K1/RPS6KA2/CALM2/MAP3K3/KRAS/NFKBIE	1.77286486669009
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/887	71/9376	1.637677247249	JUN/NFKB1/LYN/PAK1/PLCG2/F11R/ATP6V1F/ATP6V0C/IKBKB/ATP6V1A/MAP3K14	1.74337610145972
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/887	55/9376	1.72971200163985	SGMS1/GLA/PLPP3/ASAH1/PSAP/SPTLC2/SGPP1/HEXA/SPTLC3	1.75436825912993
Human Diseases	Immune disease	hsa05310	Asthma	6/887	32/9376	1.98196166854566	HLA-DPA1/HLA-DQA1/IL10/HLA-DRB1/HLA-DMB/HLA-DMA	1.79854906817429
Organismal Systems	Immune system	hsa04611	Platelet activation	17/887	126/9376	1.42617347577889	PLA2G4A/TBXAS1/RASGRP2/PLA2G4C/LYN/GNA13/RHOA/LCP2/PLCG2/VAMP8/PTGS1/PPP1CB/SNAP23/GP6/APBB1IP/ROCK2/FCGR2A	1.55675404940942
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/887	41/9376	1.80471306404158	ATM/RBBP8/RAD51B/NBN/BABAM2/POLD4/BARD1	1.66914859201144
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	20/887	154/9376	1.37278730288877	FOS/MEF2C/JUN/PLA2G4A/PRKAG2/PLA2G4C/RHOA/TRPM2/CAMK1D/PPP3CA/PPP1CB/RGS2/MAP2K5/CAMK2D/ROCK2/NFATC3/EEF2K/CALM2/KRAS/KCNJ2	1.50774568656586
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/887	119/9376	1.42123861946131	FOS/MMP9/JUNB/JUN/NFKB1/ICAM1/TNFAIP3/CREB1/CXCL10/BIRC3/BCL3/IKBKB/MLKL/MAP2K6/CCL2/MAP3K14	1.49480902383886
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/887	42/9376	1.76174370537392	FTH1/GPX4/HMOX1/SAT1/ATG5/ACSL1/NCOA4	1.59925899615537
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/887	12/9376	2.64261555806088	NCAM1/FCGR2B/CD46	1.84041190444535
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	20/887	157/9376	1.34655569837497	FOS/JUN/NFKB1/PRKAG2/UQCR10/ADIPOR2/NDUFA5/IKBKB/COX6B1/UQCRB/NDUFA7/COX8A/NDUFS8/UQCR11/NDUFA4/NDUFS7/COX5B/NDUFB10/IL1A/NDUFS6	1.41546828934847
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/887	94/9376	1.4618724363741	FOS/HSP90AA1/MMP9/JUN/FOSB/NFKB1/JUND/TNFAIP3/USP25/CXCL10/HSP90AB1/IKBKB/CCL2	1.45473661943729
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	11/887	77/9376	1.51006603317765	NFKB1/GADD45B/RB1/BRAF/TGFB2/IKBKB/TGFBR1/CDKN1B/POLK/KRAS/CDKN2A	1.45268958733053
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/887	69/9376	1.53195104815123	FOS/JUN/FOSB/MAOA/CREB1/MAOB/PPP3CA/PPP1CB/CAMK2D/CALM2	1.43354238698851
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/887	44/9376	1.68166444603874	B4GALT1/MGAT4A/FUT8/MAN2A1/HEXA/HEXD/RPN1	1.46497022315362
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/887	169/9376	1.31348938980541	SQSTM1/TANK/VPS41/WDR45B/UVRAG/GABARAP/ATG4C/DEPTOR/C9orf72/STX7/HIF1A/VAMP8/CALCOCO2/ATG5/ATG14/UBA52/NRBF2/SH3GLB1/RAB8A/KRAS/PIK3C3	1.3293101124603
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/887	105/9376	1.40939496429914	JUN/SQSTM1/GABARAP/USP15/HIF1A/CITED2/CALCOCO2/RHOT1/AMFR/UBA52/OPA1/CCZ1/MTX2/KRAS	1.36361897758596
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	27/887	227/9376	1.25727964876905	B2M/HLA-A/CXCR4/NFKB1/CREB1/CCL4/GNA13/HLA-C/RHOA/PTGER4/PPP3CA/GNB4/RB1/CCL3/HLA-E/IKBKB/CTNNB1/EIF4EBP1/MAP2K6/CGAS/CCL2/ROCK2/NFATC3/CALM2/PDGFRA/KRAS/CDKN2A	1.26838392790289
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	41/887	362/9376	1.19720704840327	PRL/HSP90AA1/CCND3/NR4A1/PRLR/YWHAZ/PDGFC/NFKB1/ITGA1/TLR2/YWHAH/CREB1/IL2RB/SGK3/PPP2R5E/VTN/IGF1/PKN2/ITGA6/GNB4/OSM/LPAR6/HGF/JAK2/SGK1/ITGA4/HSP90AB1/LPAR1/MCL1/COL4A6/CSF3R/IKBKB/PPP2R5C/IL7/EIF4EBP1/CDKN1B/LPAR5/LAMA4/PDGFRA/KDR/KRAS	1.2369072149226
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/887	71/9376	1.48879749749909	PRL/FOS/PRLR/NFKB1/STAT1/ESR1/JAK2/SOCS6/CISH/KRAS	1.33634668520717
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/887	63/9376	1.51006603317765	CCNH/POLR2J/ERCC1/POLR2J3/RBX1/POLR2K/POLE4/MNAT1/POLD4	1.31301914367055
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/887	63/9376	1.51006603317765	WNT4/GADD45B/WNT6/FZD1/WNT5A/APC/CTNNB1/POLK/SUFU	1.31301914367055
NA	NA	hsa04517	IgSF CAM signaling	34/887	299/9376	1.20199236085712	SRGAP1/CADM1/NCK1/NCAM1/IL1RAP/NFASC/ICAM1/INPP5D/CASK/LYN/RASA1/CD96/CD2AP/RHOA/PAK1/LCP2/ERC1/PLCG2/EPB41L3/CD86/ITGA4/F11R/NECTIN2/VAV3/SRGAP2/SRGAP3/CRTAM/CTNNB1/VAV1/CD2/KDR/TUBA3E/IQGAP1/PMP22	1.14740979495555
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	13/887	100/9376	1.37416009019166	CXCR4/IL2RB/CCL8/XCL2/CCL4/IL10/XCL1/CXCL10/CCL3/TNFSF10/CCL2/IL20RB/CCL23	1.21589556097329
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/887	73/9376	1.44800852496487	PDGFC/GADD45B/IGF1/RB1/HGF/BRAF/POLK/PDGFRA/KRAS/CDKN2A	1.24209661716792
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/887	73/9376	1.44800852496487	FHIT/GADD45B/PLCG2/RB1/HGF/BRAF/POLK/KRAS/RASSF1/CDKN2A	1.24209661716792
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	27/887	232/9376	1.23018310461455	RGCC/CXCR4/SSH2/PDGFC/ITGA1/ITGAD/GNA13/RHOA/PAK1/ITGA6/ARHGEF6/SCIN/ITGA4/BRAF/LPAR1/PPP1CB/APC/VAV3/PFN1/LIMK2/IQGAP2/ROCK2/LPAR5/VAV1/PDGFRA/KRAS/IQGAP1	1.14754178534853
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/887	56/9376	1.51006603317765	DISP1/GRK3/BTRC/GAS1/SPOPL/CSNK1G2/CSNK1G3/SUFU	1.23746134660549
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	17/887	138/9376	1.30215839092855	YWHAZ/CDK1/CPEB3/YWHAH/PPP2R5E/IGF1/SPDYE2/PPP3CA/RBX1/PPP1CB/BTRC/ANAPC16/PPP2R5C/CAMK2D/RPS6KA2/CDC27/CALM2	1.1558577909419
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	29/887	253/9376	1.21163401081052	JUN/C3/NFKB1/SQSTM1/RIPK2/ELMO1/TLR5/MALT1/CAST/RHOA/ATM/PLCG2/RBX1/PYCARD/HCLS1/CALCOCO2/BTRC/PFN1/ATG5/IKBKB/U2AF1/ATG14/UBA52/UBE2D3/CGAS/ROCK2/SEPTIN7/PIK3C3/CASP1	1.10305220493439
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	24/887	205/9376	1.23751752962851	MMP9/REN/NCF1/NFKB1/TBC1D4/UQCR10/PPP1CB/TGFB2/NDUFA5/ATP5MC2/COX6B1/UQCRB/TGFBR1/NDUFA7/COX8A/CAMK2D/NDUFS8/ATP5PD/UQCR11/NDUFA4/NDUFS7/COX5B/NDUFB10/NDUFS6	1.11143337179987
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	12/887	93/9376	1.36393061061207	RHOA/NLK/CTNND1/NECTIN2/CCM2/FER/CTNNB1/WAS/TGFBR1/ROCK2/PDCD10/IQGAP1	1.14007931594614
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/887	93/9376	1.36393061061207	NFKB1/FHIT/GADD45B/BIRC3/ITGA6/RB1/COL4A6/APAF1/IKBKB/CDKN1B/LAMA4/POLK	1.14007931594614
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	27/887	235/9376	1.21447863944926	PRKAG2/CREB1/PLIN1/UQCR10/DPF3/COA1/ARID1B/CNR1/ACSL1/ATP5MG/NDUFA5/ATP5MC2/COX6B1/UQCRB/NDUFA7/COX8A/NDUFS8/ATP5PD/UQCR11/RPS6KA2/NDUFA4/SMARCB1/NDUFS7/KRAS/COX5B/NDUFB10/NDUFS6	1.07631725818074
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/887	23/9376	1.83834125778148	REN/PRCP/LNPEP/CTSA	1.30115331351653
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	20/887	168/9376	1.25838836098137	PRL/CCND3/STAT4/PRLR/IL2RB/STAT1/IL10/STAT2/IRF9/OSM/JAK2/SOCS6/MCL1/CISH/CSF3R/PIAS1/IL7/IL20RB/IL13RA1/PDGFRA	1.09235578748883
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	21/887	178/9376	1.24707700492761	CCND3/JUN/LGR4/DKK1/WNT4/DAAM1/INVS/WNT6/RHOA/NLK/PPP3CA/RBX1/FZD1/WNT5A/APC/BTRC/NKD1/CTNNB1/CAMK2D/ROCK2/NFATC3	1.07575855382107
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/887	122/9376	1.29964699576765	ATP1B3/WNT4/NCOA2/TBC1D4/STAT1/NCOA1/PLCG2/ESR1/HIF1A/KAT2B/CTNNB1/MED13L/KRAS/PFKFB2/SLC16A10	1.07682288547049
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/887	41/9376	1.54689691203564	MMP9/RB1/BRAF/KRAS/RASSF1/CDKN2A	1.13438224317497
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	40/887	368/9376	1.14896328611343	RANBP2/SQSTM1/CHCHD10/TANK/NUP58/UQCR10/PPP3CA/C9orf72/NUP160/PFN1/APAF1/ANG/NDUFA5/ATG14/NRBF2/ATF6/ATP5MC2/COX6B1/UQCRB/MAP2K6/NDUFA7/COX8A/PSMA4/NDUFS8/ATP5PD/PSMA1/RAB8A/UQCR11/NUP214/SRSF7/NDUFA4/NXT1/NDUFS7/TUBA3E/COX5B/NDUFB10/ALS2/NDUFS6/PIK3C3/CASP1	0.942341128096774
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	15/887	125/9376	1.26845546786922	SGMS1/NFKB1/ASAH1/ADORA3/PPP2R5E/GNA13/RHOA/SPTLC2/PPP2R5C/ROCK2/SGPP1/KRAS/ORMDL2/SPTLC3/SPTSSB	0.976679565671868
NA	NA	hsa04518	Integrin signaling	18/887	154/9376	1.23550857259989	CCND3/C3/PDGFC/ITGA1/ITGAD/ICAM1/VTN/IGF1/ITGA6/ARHGEF6/HGF/ITGA4/FERMT2/COL4A6/CTNNB1/LAMA4/PDGFRA/KDR	0.9525191221245
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/887	174/9376	1.21499565887857	HSP90AA1/HSPH1/HSPA1B/HSPA1A/DNAJB1/NFE2L2/PPP1R15A/RBX1/NGLY1/HSP90AB1/UGGT2/UBE4B/ERLEC1/AMFR/ATF6/UBE2D3/SSR1/FBXO6/RPN1/DNAJA1	0.925299615871976
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/887	52/9376	1.42294683895586	APOA1/NCEH1/TSPO/NPC2/STARD3NL/APOC3/LDLR	0.988565623482201
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	15/887	128/9376	1.23872604284104	PDE3B/LACC1/FHIT/NUDT2/NUDT16/ENTPD1/DCK/PDE4D/RRM2B/PDE4B/PDE7A/AK3/GMPR/ENPP1/AK5	0.879022627709993
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	30/887	275/9376	1.15314133442657	HSPA1B/HSPA1A/NCAM1/C1QB/NCF1/CREB1/UQCR10/C1QA/EGR1/PPP3CA/C1QC/APAF1/NDUFA5/ATP5MC2/COX6B1/UQCRB/NDUFA7/COX8A/PSMA4/NDUFS8/ATP5PD/PSMA1/UQCR11/NDUFA4/NDUFS7/TUBA3E/COX5B/NDUFB10/IL1A/NDUFS6	0.833169566908294
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	17/887	148/9376	1.21417471586581	FOS/JUN/WNT4/GADD45B/WNT6/IGF1/NCOA1/RB1/ESR1/FZD1/WNT5A/BRAF/APC/CTNNB1/NFKB2/POLK/KRAS	0.848915465316746
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/887	18/9376	1.76174370537392	AGA/HEXA/HEXD	1.04561736608231
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/887	18/9376	1.76174370537392	TCN2/MMADHC/LMBRD1	1.04561736608231
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/887	139/9376	1.2167438540712	FOS/HSP90AA1/MMP9/FKBP5/HSPA1B/HSPA1A/JUN/NCOA2/KRT23/CREB1/NCOA1/ESR1/HSP90AB1/CALM2/KRAS/EBAG9	0.832162040282839
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/887	10/9376	2.1140924464487	MPST/ETHE1	1.13936620688648
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	26/887	238/9376	1.15475637831232	PDGFC/RALGAPA1/NFKB1/RASA2/PLA2G4A/RASGRP2/PLA2G4C/RASA1/RHOA/PAK1/IGF1/PLCG2/GNB4/HGF/NF1/RGL1/IKBKB/RALGDS/RALGAPB/RASAL3/CALM2/PDGFRA/KDR/KRAS/ZAP70/RASSF1	0.781682952363528
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	29/887	268/9376	1.14381867438456	DUSP1/MAOA/NFE2L2/LRRK2/UQCR10/MAOB/UBE2L6/APAF1/NDUFA5/UBA52/ATF6/ATP5MC2/COX6B1/UQCRB/NDUFA7/COX8A/CAMK2D/PSMA4/NDUFS8/ATP5PD/PSMA1/UQCR11/CALM2/NDUFA4/NDUFS7/TUBA3E/COX5B/NDUFB10/NDUFS6	0.772129861546152
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	32/887	298/9376	1.13508319272414	PRL/IL1RL1/CXCR4/PRLR/IL1RAP/TNFSF13B/TNFSF12/TNFRSF18/IL2RB/CCL8/XCL2/CCL4/IL10/XCL1/CXCL10/OSM/CCL3/EDA/TNFSF10/BMPR2/TGFB2/CSF3R/TNFSF18/IL7/TGFBR1/TNFSF8/CCL2/IL20RB/IL1R2/IL13RA1/IL1A/CCL23	0.76600841551302
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/887	36/9376	1.46811975447827	PRIM2/RNASEH2C/POLE4/POLD4/PRIM1	0.909607352515002
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/887	93/9376	1.25026972639439	JUN/PLA2G4A/PLA2G4C/EGR1/MAP3K2/MAP2K6/CAMK2D/MAP3K1/CALM2/MAP3K3/KRAS	0.784015771550186
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/887	65/9376	1.30097996704536	GLA/AKR1B1/PLPP3/MBOAT1/AKR1A1/GK/LCLAT1/DGKZ	0.787073493222718
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/887	104/9376	1.21966871910502	SGMS1/PLA2G4A/PLPP3/PLA2G4C/ETNK1/GPD2/LPCAT2/MBOAT1/LYPLA1/CHPT1/LCLAT1/DGKZ	0.728144137360365
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	22/887	203/9376	1.14556733551408	CCND3/JUN/PDGFC/ITGA1/RHOA/PAK1/VTN/IGF1/BIRC3/ITGA6/HGF/ITGA4/BRAF/PPP1CB/COL4A6/VAV3/CTNNB1/ROCK2/LAMA4/VAV1/PDGFRA/KDR	0.677759223013105
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/887	144/9376	1.17449580358261	KLF4/WNT4/SKIL/WNT6/IGF1/HESX1/JAK2/ID3/FZD1/WNT5A/BMPR2/APC/CTNNB1/KAT6A/KRAS/SMAD5	0.682083457280219
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/887	38/9376	1.39085029371625	ATP1B3/IGF1/SGK1/NR3C2/KRAS	0.780359079004542
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/887	38/9376	1.39085029371625	PTPRC/CIITA/BLNK/CD3E/ZAP70	0.780359079004542
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/887	29/9376	1.45799479065428	PAK1/STK3/RASSF2/RASSF1	0.798440572159576
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/887	20/9376	1.58556933483653	FDFT1/SC5D/EBP	0.84735890534949
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	17/887	155/9376	1.15934101902026	AHR/NR4A1/WNT4/CREB1/WNT6/NCEH1/RB1/FZD1/WNT5A/BRAF/APC/CTNNB1/CAMK2D/CDKN1B/KMT2A/LDLR/CDKN2A	0.646581999095793
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/887	30/9376	1.40939496429914	NFKB1/ABCC3/IKBKB/SHMT1	0.725954525172851
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/887	49/9376	1.29434231415227	JUN/FOSB/NFKB1/MAOA/CREB1/MAOB	0.667726992927136
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	17/887	158/9376	1.13732821486164	WNT4/RICTOR/WNT6/RHOA/IGF1/DEPTOR/SGK1/FZD1/WNT5A/ATP6V1F/SLC38A9/BRAF/IKBKB/EIF4EBP1/ATP6V1A/RPS6KA2/KRAS	0.56271584934455
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/887	69/9376	1.22556083852099	REN/PDE3B/CREB1/KCNMA1/PTGER4/PPP3CA/CALM2/KCNJ2	0.607858606517073
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/887	99/9376	1.17449580358261	IL1RAP/PLA2G4A/PLA2G4C/IGF1/PTGER4/PRKCH/PLCG2/PPP1CB/MAP2K6/CAMK2D/CALM2	0.564180391002193
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/887	50/9376	1.26845546786922	MAOA/SAT1/MAOB/SMS/GAMT/P4HA1	0.615217572824613
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/887	60/9376	1.23322059376174	PLA2G4A/PLA2G4C/LYN/GNA13/IGF1/BRAF/KRAS	0.585796757277424
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	21/887	200/9376	1.10989853438557	FOS/JUN/NCK1/NFKB1/MYO5A/TLR5/GNA13/RHOA/PAK1/PYCARD/TMED10/HCLS1/TNFSF10/LPAR1/CLDN4/IKBKB/ROCK2/LPAR5/FCGR2A/TUBA3E/CASP1	0.507807811666062
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	8/887	70/9376	1.20805282654212	NFKB1/PRKAG2/JAK2/ADIPOR2/APPL1/ACSL1/IKBKB/NFKBIE	0.564755276989354
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/887	70/9376	1.20805282654212	JUN/PAK1/RBX1/HGF/HIF1A/BRAF/TGFB2/KRAS	0.564755276989354
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/887	110/9376	1.15314133442657	DCN/SKIL/RHOA/FST/RBX1/ID3/BMPR2/TGFB2/SKI/TGFBR1/LEMD3/SMAD5	0.522229983633765
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	12/887	110/9376	1.15314133442657	HSP90AA1/PDE3B/CDK1/CPEB3/IGF1/SPDYE2/HSP90AB1/BRAF/ANAPC16/RPS6KA2/CDC27/KRAS	0.522229983633765
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/887	22/9376	1.44142666803321	MAOA/MAOB/HNMT	0.670024071713122
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/887	51/9376	1.24358379202865	PLA2G4A/PLPP3/PLA2G4C/LPCAT2/AGPS/CHPT1	0.563804108463492
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/887	32/9376	1.32130777903044	B4GALT1/GLA/AKR1B1/GAA	0.588503426440497
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/887	32/9376	1.32130777903044	GABARAP/ATG4C/ATG5/PIK3C3	0.588503426440497
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/887	63/9376	1.17449580358261	PLA2G4A/TBXAS1/PLA2G4C/GPX4/ALOX5/PTGS1/PTGES3	0.449189547413658
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/887	14/9376	1.51006603317765	B4GALT1/FUT8	0.617341231979035
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	17/887	166/9376	1.08251721655506	MEF2C/MEF2A/PDE3B/ATP1B3/ADORA3/CREB1/GNA13/RHOA/KCNMA1/PPP3CA/PPP1CB/KCNMB1/GTF2I/RGS2/ROCK2/NFATC3/CALM2	0.346727254170923
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/887	34/9376	1.24358379202865	POLR2J/POLR2J3/POLR2K/POLR3GL	0.459925083111365
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/887	115/9376	1.10300475466889	DUSP1/PLA2G4A/MAOA/PLA2G4C/KCND2/MAOB/GNB4/ALOX5/BRAF/PTGS1/GABRB2/KRAS	0.359249714339082
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/887	75/9376	1.12751597143931	BIRC3/ATM/ERCC1/PMAIP1/MGST2/APAF1/GSTP1/CDKN2A	0.358384794018158
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/887	15/9376	1.40939496429914	TPK1/AK5	0.51291592662786
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	47/887	480/9376	1.03502442690718	DKK1/WNT4/NFKB1/SQSTM1/TANK/ATXN1/WNT6/LRRK2/UQCR10/PPP3CA/C9orf72/FZD1/WNT5A/BRAF/APC/UBE2L6/APAF1/NDUFA5/CTNNB1/ATG14/UBA52/NRBF2/ATF6/ATP5MC2/COX6B1/UQCRB/MAP2K6/NDUFA7/COX8A/CAMK2D/PSMA4/NDUFS8/ATP5PD/PSMA1/RAB8A/UQCR11/CALM2/NDUFA4/NDUFS7/TUBA3E/KRAS/COX5B/NDUFB10/IL1A/ALS2/NDUFS6/PIK3C3	0.254632275264692
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/887	86/9376	1.10621116383944	JUN/NCK1/PAK1/PLCG2/BRAF/EIF4EBP1/CAMK2D/CDKN1B/KRAS	0.319838483596584
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	38/887	388/9376	1.03525145573519	EIF2AK2/DKK1/WNT4/NFKB1/WNT6/UQCR10/PPP3CA/FZD1/WNT5A/BRAF/APC/APAF1/NDUFA5/IKBKB/CTNNB1/ATG14/NRBF2/ATF6/ATP5MC2/COX6B1/UQCRB/NDUFA7/COX8A/PSMA4/NDUFS8/ATP5PD/PSMA1/UQCR11/CALM2/NDUFA4/NDUFS7/TUBA3E/KRAS/COX5B/NDUFB10/IL1A/NDUFS6/PIK3C3	0.22923481064703
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/887	56/9376	1.13254952488323	B4GALT1/MGAT4A/FUT8/MAN2A1/ALG6/RPN1	0.321575840939792
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/887	46/9376	1.14896328611343	PSMB9/PSME2/PSME4/PSMA4/PSMA1	0.327368221889072
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/887	108/9376	1.07662115328406	RANBP2/NUP58/NUP160/THOC2/KPNA1/SRRM1/NUP214/XPO4/NXT1/UPF2/NMD3	0.258872984777865
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/887	36/9376	1.17449580358261	GALNT2/C1GALT1/GALNT15/GCNT1	0.339064233891731
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/887	98/9376	1.07861859512689	INPP5D/PLCG2/PIK3C2A/INPP5B/MTM1/IMPA1/CALM2/DGKZ/PPIP5K2/PIK3C3	0.252889218315263
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/887	67/9376	1.10437665112992	PPP3CA/BRAF/PPP1CB/CAMK2D/RPS6KA2/CALM2/KRAS	0.277145879567095
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	15/887	150/9376	1.05704622322435	WNT4/GADD45B/WNT6/RB1/HGF/FZD1/WNT5A/BRAF/APC/TGFB2/CTNNB1/TGFBR1/CDKN1B/POLK/KRAS	0.22765908327496
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/887	26/9376	1.21966871910502	APOA1/TCN2/LMBRD1	0.36255029891157
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/887	140/9376	1.05704622322435	KLF2/MEF2C/MEF2A/PDE3B/PRKAG2/SERPINE1/GNA13/PLIN1/EGR1/GNB4/TGFBR1/CALM2/KRAS/PIK3C3	0.219820470986351
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/887	16/9376	1.32130777903044	MAOA/MAOB	0.415778940723393
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/887	16/9376	1.32130777903044	GLA/HEXA	0.415778940723393
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/887	78/9376	1.0841499725378	INPP5D/PLCG2/PIK3C2A/INPP5B/MTM1/IMPA1/PPIP5K2/PIK3C3	0.241226874761363
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/887	99/9376	1.06772345780238	FOS/MMP9/JUN/IGF1/RB1/ESR1/BRAF/CDKN1B/KRAS/CDKN2A	0.218963700665016
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/887	68/9376	1.08813581802507	NFKB1/SPI1/BRAF/PML/IKBKB/EIF4EBP1/KRAS	0.235775074146937
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/887	89/9376	1.06892314708081	PDGFC/CDK1/GJA1/LPAR1/MAP2K5/MAP3K2/PDGFRA/TUBA3E/KRAS	0.211174542172243
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/887	37/9376	1.14275267375606	APOA1/ICAM1/IL10/LAMA4	0.28122511755048
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/887	79/9376	1.0704265551639	SLC1A3/ATP6V1F/SLC1A1/STX2/ATP6V0C/AP2A2/ATP6V1A/VAMP2	0.203187860499583
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/887	90/9376	1.05704622322435	NFKB1/PRKAG2/CREB1/IGF1/ATG5/ADIPOR2/APPL1/EIF4EBP1/KRAS	0.175773335236014
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/887	143/9376	1.03487042833153	HLA-DPA1/C3/C1QB/HLA-DQA1/IL10/C1QA/CD86/C2/HLA-DRB1/C1QC/HLA-DMB/HLA-DMA/FCGR2A/TRIM21	0.135822920439025
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/887	59/9376	1.07496226090612	GADD45B/BRAF/APC/CTNNB1/POLK/KRAS	0.186702363611098
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	14/887	144/9376	1.02768382813479	C3/C1QB/NFKB1/TRA2B/PRKAG2/LY96/C1QA/C2/C1QC/ADIPOR2/IKBKB/CTNNB1/MAP2K6/MAP3K14	0.108212809805405
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/887	49/9376	1.07861859512689	B4GALT1/GALNT2/C1GALT1/FUT10/GALNT15	0.17834934220527
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/887	28/9376	1.13254952488323	AKR1B1/PCBD1/MOCS2	0.22704765486118
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/887	28/9376	1.13254952488323	ATP6V1F/ATP6V0C/ATP6V1A	0.22704765486118
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/887	60/9376	1.05704622322435	PLA2G4A/PLA2G4C/PLCG2/PPP3CA/KDR/KRAS	0.143287057290869
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/887	83/9376	1.01883973322829	L3MBTL4/SFMBT2/SFMBT1/SCMH1/UBE2D3/ASXL2/MBD5/SUZ12	0.055725632663091
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/887	51/9376	1.03631982669054	PLCG2/ATP6V1F/KDELR1/ATP6V0C/ATP6V1A	0.0840666258467661
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/887	62/9376	1.02294795795905	HSPA1B/HSPA1A/PRKAG2/IGF1/ATG5/KRAS	0.0585991012060791
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/887	19/9376	1.112680234973	BCKDHB/OGDH	0.158918849029625
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/887	41/9376	1.03126460802376	MAOA/MAOB/GAMT/SHMT1	0.0648495455020334
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/887	149/9376	0.993197793633619	PDGFC/PLA2G4A/PLPP3/PLA2G4C/GNA13/RHOA/PLCG2/LPAR6/LPAR1/LPAR5/RALGDS/PDGFRA/DGKZ/KRAS	-0.0270540232372395
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/887	52/9376	1.01639059925418	PLA2G4A/PLA2G4C/IGF1/ALOX5/LDLR	0.03831021177735
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/887	63/9376	1.0067106887851	SMYD3/CAMKMT/NSD1/SETD7/KMT2A/SETDB2	0.0172747492852139
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/887	107/9376	0.987893666564815	PDE3B/PRKAG2/SIK2/CREB1/PPP3CA/PPP4R3A/CAMK2D/PHKB/CALM2/PPP4C	-0.0407105772329195
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/887	42/9376	1.0067106887851	MAOA/MAOB/KYNU/KYAT3	0.0140888980561999
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/887	31/9376	1.02294795795905	RBKS/DERA/TKT	0.0413670375903657
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/887	76/9376	0.973595205601377	APOA1/OLR1/PLIN1/ME1/ACSL1/GK/APOC3	-0.074708031526678
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/887	87/9376	0.971996527102852	ATP1B3/UQCR10/COX6B1/UQCRB/COX8A/UQCR11/ASPH/COX5B	-0.084821553180133
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/887	54/9376	0.978746502985511	LACC1/SMS/MPST/AHCYL2/KYAT3	-0.0506281327624572
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	9/887	98/9376	0.970756735614201	NR4A2/NR4A1/ATP1B3/CREB1/CAMK1D/CAMK2D/LDLR/CALM2/PRKD3	-0.0940656120803921
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/887	32/9376	0.99098083427283	BIRC3/PMAIP1/APAF1	-0.0165193944263999
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/887	110/9376	0.960951112022138	NFKB1/SERPINE1/HMOX1/IGF1/PLCG2/RBX1/HIF1A/EIF4EBP1/CAMK2D/CDKN1B	-0.133161306227054
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/887	21/9376	1.0067106887851	CSGALNACT1/DSE	0.00995116738052278
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/887	21/9376	1.0067106887851	DPYD/ENPP1	0.00995116738052278
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/887	44/9376	0.960951112022138	CCNH/TAF3/GTF2I/MNAT1	-0.0839202608662651
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/887	44/9376	0.960951112022138	POLE4/PARP4/POLD4/MBD4	-0.0839202608662651
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/887	122/9376	0.95307446356294	FOS/JUNB/IGFBP3/CREB1/STAT1/IGF1/PLCG2/JAK2/MAP2K6/MAP3K1/KRAS	-0.168633399507159
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/887	133/9376	0.953725915691144	FOS/MAOA/CREB1/PPP2R5E/MAOB/PPP3CA/GNB4/PPP1CB/COMT/PPP2R5C/CAMK2D/CALM2	-0.17373061570201
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/887	89/9376	0.950153908516271	ITGA1/VTN/ITGA6/ITGA4/COL4A6/CD47/GP6/LAMA4	-0.152724099144969
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	28/887	308/9376	0.960951112022138	SLC1A3/CREB1/POLR2J/UQCR10/POLR2J3/POLR2K/APAF1/NDUFA5/ATG14/NRBF2/ATP5MC2/COX6B1/AP2A2/UQCRB/NDUFA7/COX8A/PSMA4/NDUFS8/ATP5PD/PSMA1/UQCR11/NDUFA4/NDUFS7/TUBA3E/COX5B/NDUFB10/NDUFS6/PIK3C3	-0.225241004007885
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/887	101/9376	0.94192237713061	WNT4/CREB1/WNT6/FZD1/WNT5A/CTNNB1/CAMK2D/CALM2/KRAS	-0.189684455114349
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/887	103/9376	0.923632622234871	PPP2R5E/PPP1CB/PAPOLA/PPP2R5C/RNMT/SRRM1/NXT1/UPF2/CPSF6	-0.251904277535963
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/887	103/9376	0.923632622234871	COL14A1/CPB1/ATP1B3/KCNE3/COL23A1/SLC1A1/COL4A6/PRCP/SLC16A10	-0.251904277535963
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/887	35/9376	0.906039619906587	AKR1B1/HSD17B14/PFKFB2	-0.180011927586498
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/887	59/9376	0.895801884088434	GPX4/SMS/MGST2/RRM2B/GSTP1	-0.259517713171379
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/887	82/9376	0.902356532020788	DPYD/CMPK1/MGST2/RRM2B/GSTP1/TK2/CDA	-0.287056885927685
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/887	36/9376	0.88087185268696	AKR1B1/CRYL1/AKR1A1	-0.23147888473154
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/887	36/9376	0.88087185268696	AGL/GAA/ENPP1	-0.23147888473154
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/887	48/9376	0.88087185268696	HIBADH/HIBCH/AUH/BCKDHB	-0.26746066431824
NA	NA	hsa03272	Virion - Hepatitis viruses	4/887	48/9376	0.88087185268696	CD81/CLDN4/LDLR/PDCD6IP	-0.26746066431824
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/887	37/9376	0.857064505317042	MAOA/MAOB/COMT	-0.281585277786404
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/887	62/9376	0.852456631632542	MAML3/ATXN1/DTX3L/KAT2B/DTX2	-0.376761574632429
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/887	38/9376	0.834510176229751	GALK2/HEXA/NAGK	-0.330411639797126
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/887	38/9376	0.834510176229751	NAMPT/NADK/ENPP1	-0.330411639797126
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/887	86/9376	0.860386460764007	ITGA1/GJA1/ITGA6/LMNA/ITGA4/DSC2/CTNNB1	-0.420424568045373
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/887	26/9376	0.813112479403348	PLA2G4A/PLA2G4C	-0.308446859121371
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/887	39/9376	0.813112479403348	MTHFD1L/SHMT1/AHCYL2	-0.37803160293646
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/887	122/9376	0.866431330511764	PRKAG2/CREB1/PPP2R5E/IGF1/ADIPOR2/PPP2R5C/EIF4EBP1/RAB8A/EEF2K/PFKFB2	-0.479997470751572
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/887	134/9376	0.86772451160208	PLA2G4A/PLA2G4C/GNA13/RHOA/KCNMA1/PRKCH/BRAF/PPP1CB/KCNMB1/ROCK2/CALM2	-0.498503224876181
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/887	27/9376	0.782997202388409	HACD4/TECR	-0.364992395653081
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/887	217/9376	0.876812535393472	FOS/HSP90AA1/CCND3/JUN/KLF4/AHR/NFKB1/CREB1/RB1/ESR1/JAK2/HSP90AB1/MGST2/PTGES3/EIF4EBP1/KPNA1/RPS6KA2/KRAS	-0.593460113880901
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/887	28/9376	0.755033016588823	HACD4/TECR	-0.419610550478561
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/887	78/9376	0.813112479403348	ELMO1/CD2AP/RHOA/HCLS1/CTNNB1/RHOG	-0.535737459749988
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/887	54/9376	0.782997202388409	ERCC1/ATR/FANCL/POLK	-0.516924176751454
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/887	91/9376	0.813112479403348	PDE3B/GRK3/GNB4/GABRB2/PDE4D/PDE4B/PDE7A	-0.579067546458635
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/887	15/9376	0.704697482149568	HEXA	-0.369973687483177
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/887	116/9376	0.820122069743031	SLC1A3/PLA2G4A/PLA2G4C/SLC38A1/GRK3/PPP3CA/GNB4/SLC1A1/HOMER2	-0.630116082615051
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/887	30/9376	0.704697482149568	PLA2G4A/PLA2G4C	-0.523641514485796
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/887	44/9376	0.720713334016603	CREB1/ARHGDIB/VAMP2	-0.600217088872892
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/887	31/9376	0.681965305306033	HSD17B14/AKR1A1	-0.573303872785654
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/887	31/9376	0.681965305306033	DPYD/HIBCH	-0.573303872785654
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/887	31/9376	0.681965305306033	SEC11C/IMMP2L	-0.573303872785654
NA	NA	hsa04981	Folate transport and metabolism	2/887	31/9376	0.681965305306033	ABCC3/SHMT1	-0.573303872785654
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/887	17/9376	0.621791896014324	KYAT3	-0.50449834833721
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/887	17/9376	0.621791896014324	PCDH20	-0.50449834833721
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/887	32/9376	0.66065388951522	HIBCH/BCKDHB	-0.621542215293297
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/887	97/9376	0.762816862120666	FOS/PER3/PER1/CREB1/GNB4/CAMK2D/CALM2	-0.758993875488889
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/887	46/9376	0.689377971668055	FTH1/HMOX1/BLVRA	-0.682636532448518
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/887	170/9376	0.808329464818622	JUN/PRKAG2/RHOA/HCLS1/F11R/DLG1/CLDN4/WAS/MAP3K1/ROCK2/RAB8A/PATJ/TUBA3E	-0.815198763435231
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/887	73/9376	0.724004262482433	MAOA/MAOB/MGST2/GSTP1/CYP3A5	-0.765193858644143
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/887	33/9376	0.640634074681425	BCKDHB/OGDH	-0.668451453919164
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/887	18/9376	0.587247901791307	ACSL1	-0.566569515086533
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/887	47/9376	0.674710355249586	AKR1A1/ME1/ACYP2	-0.722638011144631
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/887	195/9376	0.813112479403348	C3/NCF1/NFKB1/TLR2/PLCG2/TLR7/SELPLG/HDAC8/GSDMD/HAT1/FCGR2A/CLEC7A/CLCN5/CAMP/CASP1	-0.852455654108845
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/887	86/9376	0.737474109226292	ATP1B3/CREB1/KCNMA1/KCNMB1/CAMK2D/VAMP2	-0.790556093866352
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/887	99/9376	0.747406420461663	ITGA1/PRKAG2/IGF1/ITGA6/LMNA/ITGA4/TGFB2	-0.816686370346514
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/887	61/9376	0.693145064409411	FTH1/ATP1B3/HMOX1/ATOX1	-0.777187455842719
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/887	19/9376	0.556340117486501	HEXA	-0.625716816321487
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/887	138/9376	0.765975524075617	FLOT1/PDE3B/PRKAG2/BRAF/PPP1CB/IKBKB/EIF4EBP1/PHKB/CALM2/KRAS	-0.895222578254521
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/887	115/9376	0.735336503112592	FOS/KCNQ5/CREB1/GNB4/JAK2/CAMK2D/KRAS/KCNJ2	-0.923066958980887
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/887	20/9376	0.528523111612176	CYB5R4	-0.682259326563644
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/887	103/9376	0.718380928404899	NFKB1/TLR2/IL10/COL4A6/TGFB2/IL1R2/LAMA4	-0.928944411168525
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	17/887	226/9376	0.795123265257256	FOS/JUN/PDE3B/ATP1B3/NFKB1/CREB1/RHOA/PAK1/BRAF/PPP1CB/VAV3/PDE4D/CAMK2D/ROCK2/PDE4B/CALM2/VAV1	-1.00775624409888
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	11/887	154/9376	0.755033016588823	TPK1/CMPK2/MOCS2/CMPK1/MTHFD1L/AKR1A1/NADK/SHMT1/AK3/KYNU/AK5	-0.990773853420268
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/887	65/9376	0.650489983522678	NR4A1/CREB1/NCEH1/LDLR	-0.913981326683052
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/887	37/9376	0.571376336878028	RIMKLB/ASRGL1	-0.844395673123288
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/887	37/9376	0.571376336878028	GALK2/NAGK	-0.844395673123288
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/887	130/9376	0.731801231463013	FOS/MMP9/JUN/NFKB1/CREB1/GNB4/COL4A6/TGFBR1/KRAS	-0.995338246291027
NA	NA	hsa04519	Cadherin signaling	32/887	404/9376	0.837264335227209	YWHAZ/TAOK3/WNT4/NFKB1/KRT23/YWHAH/KRT81/DAAM1/WNT6/RHOA/GJA1/PCDH20/STK3/EVL/RERE/KRT86/CTNND1/FZD1/WNT5A/PPP1CB/APC/VAV3/GABRB2/DSC2/IKBKB/CTNNB1/ROCK2/SCN1B/VAV1/PDGFRA/KDR/KRAS	-1.08080656442709
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/887	66/9376	0.640634074681425	COMT/HSD17B11/HSD11B1/CYP3A5	-0.947007032298523
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/887	144/9376	0.734059877239133	ATXN1/ATXN10/ATG14/OMA1/NRBF2/OPA1/PUM2/PSMA4/PSMA1/PIK3C3	-1.03952848514422
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/887	53/9376	0.598328050881709	ATP1B3/ESR1/AP2A2	-0.947874364273474
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/887	23/9376	0.45958531444537	B4GALT1	-0.838754328569241
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/887	23/9376	0.45958531444537	ZMPSTE24	-0.838754328569241
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/887	23/9376	0.45958531444537	POLD4	-0.838754328569241
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/887	23/9376	0.45958531444537	ATP1B3	-0.838754328569241
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/887	109/9376	0.678837024089033	NFKB1/PRKAG2/TBC1D4/CREB1/PPP1CB/IKBKB/RPS6KA2	-1.09015517876756
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/887	149/9376	0.709426995452585	GNB4/GABRB2/CNR1/NDUFA5/NDUFA7/NDUFS8/NDUFA4/NDUFS7/NDUFB10/NDUFS6	-1.15567925959922
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/887	24/9376	0.44043592634348	EXT2	-0.887201722460931
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/887	70/9376	0.604026413271058	MGST2/GSTP1/HSD11B1/CYP3A5	-1.07486245858958
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/887	71/9376	0.595518998999635	HIF1A/SCO2/PDGFRA/KRAS	-1.10582981230816
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/887	57/9376	0.556340117486501	HACD4/ACSL1/TECR	-1.08598071524573
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/887	43/9376	0.491649406150861	APOA1/PLPP3	-1.0799561237969
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/887	26/9376	0.406556239701674	HHEX	-0.979444017154312
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/887	154/9376	0.686393651444384	CREM/ATP1B3/CREB1/PPP2R5E/PPP1CB/PPP2R5C/CAMK2D/CALM2/SCN1B/KCNE1	-1.26838713564095
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/887	59/9376	0.53748113045306	PDE3B/PLIN1/PTGS1	-1.15195786673633
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/887	89/9376	0.593846192822669	SLC38A1/GABARAP/GNB4/SLC12A5/GABRB2	-1.24442002309661
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/887	117/9376	0.632420817313715	DPF3/ARID2/TFPT/ARID1B/BRD7/SMARCB1/RSF1	-1.29324550600587
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/887	45/9376	0.469798321433045	ABCC3/ABCB7	-1.15239785656747
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/887	233/9376	0.725868651141186	FBN2/DCN/ATP1B3/ITGA1/FMNL2/NEB/DAAM1/ITGA6/LMNA/CAPZA1/NID2/FMNL1/ITGA4/COL4A6/DSC2/CAPN3	-1.36965593894788
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/887	76/9376	0.556340117486501	ATP1B3/CAMK2D/CALM2/KCNJ2	-1.25526281286511
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/887	28/9376	0.377516508294411	B4GALT1	-1.0662687558183
Genetic Information Processing	Translation	hsa03010	Ribosome	15/887	222/9376	0.714220421097535	RPL36AL/MRPS6/RPL28/RPL35/RPS24/MRPL33/RPL22L1/MRPL52/RPS15A/FAU/UBA52/RPL36A/MRPS18A/MRPL42/MRPL54	-1.39290470853612
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/887	105/9376	0.604026413271058	ITGA1/IGF1/ITGA6/LMNA/ITGA4/TGFB2	-1.31891484891796
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/887	29/9376	0.36449869766357	CALM2	-1.10789474858608
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/887	93/9376	0.568304421088361	ATP1B3/KCNMA1/VAMP2/CALM2/CAMP	-1.35236549482556
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/887	79/9376	0.53521327758195	MGST2/GSTP1/HSD11B1/CYP3A5	-1.34095753365976
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/887	30/9376	0.352348741074784	OGDH	-1.14843953431512
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/887	30/9376	0.352348741074784	PIGP	-1.14843953431512
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/887	31/9376	0.340982652653017	SHMT1	-1.18797478316167
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/887	102/9376	0.51815991334527	CPB1/ATP1B3/RHOA/KCNMA1/RAB8A	-1.5815708420365
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/887	90/9376	0.469798321433045	ATP1B3/NCEH1/ABCC3/LDLR	-1.63368076135256
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/887	191/9376	0.608770076202506	FOSB/MAOA/CREB1/MAOB/GNB4/BRAF/PPP1CB/HDAC8/HAT1/CALM2/KRAS	-1.76574648205552
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/887	41/9376	0.257816152005939	GABRB2	-1.53944950100738
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/887	254/9376	0.624239895604932	CXCR4/PDGFC/STIM2/CAMK1D/PLCG2/PPP3CA/HGF/CYSLTR1/CAMK2D/NFATC3/PHKB/CALM2/PDGFRA/KDR/ASPH	-1.96246388633759
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/887	43/9376	0.245824703075431	ACSL1	-1.60219391928505
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	20/887	323/9376	0.654517785278236	MMP9/MARCKS/NFKB1/RHOA/HMOX1/ATM/PLCG2/FOXP1/BMPR2/APC/MCL1/TGFB2/IKBKB/PLAU/BMF/CDKN1B/PDGFRA/KRAS/RASSF1/CDKN2A	-2.04244268069792
NA	NA	hsa04382	Cornified envelope formation	12/887	217/9376	0.584541690262314	KRT23/TCHH/KRT81/PPP2R5E/ITGA6/KRT86/SPTLC2/S100A11/CLDN4/COL4A6/PPP2R5C/SPTLC3	-2.00148559431125
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/887	116/9376	0.455623372079462	HIBCH/ME1/SHMT1/TKT/OGDH	-1.90696250375158
NA	NA	hsa04081	Hormone signaling	12/887	219/9376	0.579203409985946	PRL/PRLR/GNA13/RHOA/IGF1/GNB4/ESR1/JAK2/ADIPOR2/APPL1/SMAD5/SLC16A10	-2.03674586576962
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/887	47/9376	0.224903451749862	IKBKB	-1.72189381713122
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/887	68/9376	0.310895948007162	ALDH1A1/CYP3A5	-1.84344529380047
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/887	48/9376	0.22021796317174	ATP1B3	-1.75072832321876
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/887	75/9376	0.281878992859827	SHMT1/TKT	-2.01828560233755
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/887	75/9376	0.281878992859827	ATP1B3/CREB1	-2.01828560233755
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/887	194/9376	0.490382268506143	MYO5A/DYNLRB1/CAPZA1/KIF16B/MYO9A/DYNLT1/KIF2A/TUBA3E/KIF13A	-2.31844038072095
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/887	83/9376	0.254709933307073	AGPS/ACSL1	-2.20447710064249
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/887	65/9376	0.162622495880669	KRAS	-2.18977244161238
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/887	67/9376	0.15776809301856	AKR1A1	-2.23633446880087
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/887	183/9376	0.346572532204706	XRN1/MDN1/GNL2/RPP38/NXT1/NMD3	-2.88544953327865
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/887	243/9376	0.391498601194204	HSPA1B/HSPA1A/BCAS2/TRA2B/HNRNPU/RP9/THOC2/U2AF1/SRSF7	-3.10654157527513
NA	NA	hsa04082	Neuroactive ligand signaling	6/887	199/9376	0.318707403987242	SLC1A3/ADORA3/P2RY13/GNB4/SLC1A1/GABRB2	-3.13999548008498
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/887	370/9376	0.428532252658521	PRL/PRLR/C3/ADORA3/GZMA/TSPO/PTGER4/P2RY13/PGRMC2/LPAR6/CYSLTR1/LPAR1/GABRB2/CNR1/P2RY8	-3.62531540629849
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/887	449/9376	0.117711160715407	NCALD/GRK3/RGS2/CAMK2D/CALM2	-6.19298987523843