ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0030695 GTPase regulator activity 87/1652 489/18639 0.177914110429448 2.00734933674 2.05781004681129e-10 1.39725633078026e-07 GO:0060589 nucleoside-triphosphatase regulator activity 87/1652 490/18639 0.177551020408163 2.00325270544053 2.29058414882009e-10 1.39725633078026e-07 GO:0005096 GTPase activator activity 55/1652 271/18639 0.202952029520295 2.28984435728135 4.21262894769268e-09 1.71313577206169e-06 GO:0031267 small GTPase binding 50/1652 283/18639 0.176678445229682 1.99340771224942 1.78943272403532e-06 0.000545776980830773 GO:0051020 GTPase binding 53/1652 315/18639 0.168253968253968 1.89835696990661 4.02158636411509e-06 0.000981267072844082 GO:0003725 double-stranded RNA binding 20/1652 75/18639 0.266666666666667 3.00871670702179 5.49244054102382e-06 0.00111679624334151 GO:0044389 ubiquitin-like protein ligase binding 53/1652 322/18639 0.164596273291925 1.85708834012603 7.74192409285395e-06 0.00134930677046883 GO:0023023 MHC protein complex binding 13/1652 37/18639 0.351351351351351 3.9641875531706 9.28754672827025e-06 0.00141635087606121 GO:0046332 SMAD binding 19/1652 79/18639 0.240506329113924 2.71355778956079 4.54812818637685e-05 0.00616524043042195 GO:0031625 ubiquitin protein ligase binding 48/1652 302/18639 0.158940397350993 1.79327485848981 5.0963945139632e-05 0.0062176013070351 GO:0023026 MHC class II protein complex binding 10/1652 27/18639 0.37037037037037 4.17877320419693 6.00205449808165e-05 0.00665682407969056 GO:0005543 phospholipid binding 70/1652 497/18639 0.140845070422535 1.58911093680728 6.9031240740512e-05 0.00701817614195205 GO:0016504 peptidase activator activity 14/1652 57/18639 0.245614035087719 2.77118644067797 0.000351158989950457 0.0329549205953506 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 8/1652 23/18639 0.347826086956522 3.92441309611538 0.000545175568308607 0.03912366179995 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 8/1652 23/18639 0.347826086956522 3.92441309611538 0.000545175568308607 0.03912366179995 GO:0005085 guanyl-nucleotide exchange factor activity 36/1652 230/18639 0.156521739130435 1.76598589325192 0.000563726529567855 0.03912366179995 GO:0140296 general transcription initiation factor binding 13/1652 53/18639 0.245283018867925 2.7674516880625 0.000573330845261026 0.03912366179995 GO:0004674 protein serine/threonine kinase activity 59/1652 433/18639 0.136258660508083 1.53736390630155 0.000587535026813536 0.03912366179995 GO:0061659 ubiquitin-like protein ligase activity 52/1652 372/18639 0.139784946236559 1.57714988674529 0.000672110419372932 0.03912366179995 GO:0035091 phosphatidylinositol binding 42/1652 284/18639 0.147887323943662 1.66856648364765 0.000689406155480769 0.03912366179995 GO:0015485 cholesterol binding 13/1652 54/18639 0.240740740740741 2.71620258272801 0.000694694473727769 0.03912366179995 GO:0032934 sterol binding 15/1652 68/18639 0.220588235294118 2.488828158382 0.000751557795358888 0.03912366179995 GO:0035035 histone acetyltransferase binding 8/1652 24/18639 0.333333333333333 3.76089588377724 0.00075470336438326 0.03912366179995 GO:0038187 pattern recognition receptor activity 12/1652 48/18639 0.25 2.82067191283293 0.000769645805900657 0.03912366179995 GO:0044325 transmembrane transporter binding 24/1652 136/18639 0.176470588235294 1.9910625267056 0.000833388279026585 0.0406693480164973 GO:0140297 DNA-binding transcription factor binding 64/1652 488/18639 0.131147540983607 1.47969674115826 0.000969073907207635 0.0451161400427745 GO:0019211 phosphatase activator activity 8/1652 25/18639 0.32 3.61046004842615 0.00102438312754829 0.0451161400427745 GO:0106310 protein serine kinase activity 50/1652 361/18639 0.138504155124654 1.56269912068306 0.00103545239442433 0.0451161400427745 GO:0031072 heat shock protein binding 23/1652 131/18639 0.175572519083969 1.9809298929819 0.00113638035401053 0.0474942147293787 GO:0016505 peptidase activator activity involved in apoptotic process 7/1652 20/18639 0.35 3.9489406779661 0.00116789052613226 0.0474942147293787 GO:0019207 kinase regulator activity 41/1652 287/18639 0.142857142857143 1.61181252161882 0.00156307181237218 0.0600937325634416 GO:0072542 protein phosphatase activator activity 7/1652 21/18639 0.333333333333333 3.76089588377724 0.00161896959307038 0.0600937325634416 GO:0001618 virus receptor activity 16/1652 81/18639 0.197530864197531 2.22867904223836 0.00177801271237094 0.0600937325634416 GO:0016779 nucleotidyltransferase activity 23/1652 136/18639 0.169117647058824 1.90810158809286 0.00189934086582169 0.0600937325634416 GO:0140272 exogenous protein binding 16/1652 82/18639 0.195121951219512 2.20150002952814 0.00203093330341935 0.0600937325634416 GO:0061133 endopeptidase activator activity 7/1652 22/18639 0.318181818181818 3.58994607087827 0.00219468293523371 0.0600937325634416 GO:0004679 AMP-activated protein kinase activity 36/1652 248/18639 0.145161290322581 1.63780949777396 0.00221538899245692 0.0600937325634416 GO:0001540 amyloid-beta binding 16/1652 83/18639 0.192771084337349 2.17497593278684 0.00231318820689357 0.0600937325634416 GO:0019787 ubiquitin-like protein transferase activity 61/1652 479/18639 0.127348643006263 1.43683496186062 0.00253101122746423 0.0600937325634416 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 5/1652 12/18639 0.416666666666667 4.70111985472155 0.00253121475769744 0.0600937325634416 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 5/1652 12/18639 0.416666666666667 4.70111985472155 0.00253121475769744 0.0600937325634416 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 5/1652 12/18639 0.416666666666667 4.70111985472155 0.00253121475769744 0.0600937325634416 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 5/1652 12/18639 0.416666666666667 4.70111985472155 0.00253121475769744 0.0600937325634416 GO:0017124 SH3 domain binding 20/1652 115/18639 0.173913043478261 1.96220654805769 0.00259698204138981 0.0600937325634416 GO:0140313 molecular sequestering activity 12/1652 55/18639 0.218181818181818 2.4616773057451 0.00271728314298298 0.0600937325634416 GO:0043178 alcohol binding 17/1652 92/18639 0.184782608695652 2.0848444573113 0.00274738595767512 0.0600937325634416 GO:0035173 histone kinase activity 48/1652 360/18639 0.133333333333333 1.5043583535109 0.00282686532548862 0.0600937325634416 GO:0005496 steroid binding 19/1652 108/18639 0.175925925925926 1.98491727199354 0.00286935781275048 0.0600937325634416 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 35/1652 243/18639 0.1440329218107 1.62507846829881 0.0028814429181496 0.0600937325634416 GO:0061630 ubiquitin protein ligase activity 47/1652 353/18639 0.13314447592068 1.50222753431329 0.00319364802157809 0.0600937325634416 GO:0004676 3-phosphoinositide-dependent protein kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0004711 ribosomal protein S6 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0035175 histone H3S10 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0035979 histone H2AXS139 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0044022 histone H3S28 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0044023 histone H4S1 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0044024 histone H2AS1 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0044025 histone H2BS14 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0072354 histone H3T3 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0072371 histone H2AS121 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0072518 Rho-dependent protein serine/threonine kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0140823 histone H2BS36 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0140855 histone H3S57 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0140995 histone H2A kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0140997 histone H4 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0140998 histone H2B kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:1990244 histone H2AT120 kinase activity 35/1652 245/18639 0.142857142857143 1.61181252161882 0.0033002295752054 0.0600937325634416 GO:0141003 histone H2AX kinase activity 47/1652 354/18639 0.132768361581921 1.49798395370788 0.00337475515136967 0.0604488831458819 GO:0004706 JUN kinase kinase kinase activity 6/1652 18/18639 0.333333333333333 3.76089588377724 0.00350232236684839 0.0604488831458819 GO:0004677 DNA-dependent protein kinase activity 35/1652 246/18639 0.142276422764228 1.6052604381976 0.00352842511130778 0.0604488831458819 GO:0140857 histone H3T45 kinase activity 35/1652 246/18639 0.142276422764228 1.6052604381976 0.00352842511130778 0.0604488831458819 GO:0016247 channel regulator activity 26/1652 168/18639 0.154761904761905 1.74613023175372 0.00360494933707747 0.0604488831458819 GO:0099106 ion channel regulator activity 25/1652 160/18639 0.15625 1.76291994552058 0.00374688555641241 0.0604488831458819 GO:0035402 histone H3T11 kinase activity 35/1652 247/18639 0.1417004048583 1.59876140808344 0.00376993907046342 0.0604488831458819 GO:0035403 histone H3T6 kinase activity 35/1652 247/18639 0.1417004048583 1.59876140808344 0.00376993907046342 0.0604488831458819 GO:0001091 RNA polymerase II general transcription initiation factor binding 7/1652 24/18639 0.291666666666667 3.29078389830508 0.00380642907339057 0.0604488831458819 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 5/1652 13/18639 0.384615384615385 4.3394952505122 0.00381521639527287 0.0604488831458819 GO:0140996 histone H3 kinase activity 47/1652 357/18639 0.131652661064426 1.48539585325656 0.00397211125197389 0.0621278939411301 GO:0003714 transcription corepressor activity 30/1652 204/18639 0.147058823529412 1.65921877225466 0.00406312236086419 0.0627469529146115 GO:0141108 transporter regulator activity 26/1652 170/18639 0.152941176470588 1.72558752314485 0.0042373498870987 0.0646195857782552 GO:0050145 nucleoside monophosphate kinase activity 6/1652 19/18639 0.315789473684211 3.56295399515739 0.00473960911855298 0.071386705242403 GO:0004709 MAP kinase kinase kinase activity 7/1652 25/18639 0.28 3.15915254237288 0.004888335830107 0.0718526471413318 GO:0017025 TBP-class protein binding 7/1652 25/18639 0.28 3.15915254237288 0.004888335830107 0.0718526471413318 GO:0140375 immune receptor activity 24/1652 156/18639 0.153846153846154 1.73579810020488 0.00542190086128084 0.0782537662521938 GO:0030246 carbohydrate binding 38/1652 280/18639 0.135714285714286 1.53122189553788 0.00546902067456845 0.0782537662521938 GO:0016755 aminoacyltransferase activity 61/1652 496/18639 0.122983870967742 1.38758860228072 0.00551624909646612 0.0782537662521938 GO:0120015 sterol transfer activity 8/1652 32/18639 0.25 2.82067191283293 0.00570259048550884 0.0799673608312734 GO:0070412 R-SMAD binding 7/1652 26/18639 0.269230769230769 3.03764667535854 0.0061860910394515 0.0857617166833049 GO:0140311 protein sequestering activity 8/1652 33/18639 0.242424242424242 2.73519700638345 0.00695403335257652 0.0953249515746444 GO:1990782 protein tyrosine kinase binding 19/1652 117/18639 0.162393162393162 1.83223132799404 0.00704073059223967 0.0954410146948044 GO:0045296 cadherin binding 43/1652 334/18639 0.12874251497006 1.45256158385408 0.00836400082165678 0.112132758268366 GO:0004842 ubiquitin-protein transferase activity 55/1652 449/18639 0.122494432071269 1.3820664160874 0.00875233486588101 0.116063571047552 GO:0097718 disordered domain specific binding 7/1652 28/18639 0.25 2.82067191283293 0.00952670131464311 0.124973931224351 GO:0016763 pentosyltransferase activity 10/1652 49/18639 0.204081632653061 2.30258931659831 0.00971921047778141 0.126142944498865 GO:0034450 ubiquitin-ubiquitin ligase activity 5/1652 16/18639 0.3125 3.52583989104116 0.0103455487987575 0.131619903524724 GO:0070034 telomerase RNA binding 6/1652 22/18639 0.272727272727273 3.07709663218138 0.0103569760150603 0.131619903524724 GO:0033192 calmodulin-dependent protein phosphatase activity 14/1652 81/18639 0.172839506172839 1.95009416195857 0.0112765179863744 0.132282230224777 GO:0140791 histone H2AXS140 phosphatase activity 14/1652 81/18639 0.172839506172839 1.95009416195857 0.0112765179863744 0.132282230224777 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 14/1652 81/18639 0.172839506172839 1.95009416195857 0.0112765179863744 0.132282230224777 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 14/1652 81/18639 0.172839506172839 1.95009416195857 0.0112765179863744 0.132282230224777 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 14/1652 81/18639 0.172839506172839 1.95009416195857 0.0112765179863744 0.132282230224777 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 14/1652 81/18639 0.172839506172839 1.95009416195857 0.0112765179863744 0.132282230224777 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 14/1652 81/18639 0.172839506172839 1.95009416195857 0.0112765179863744 0.132282230224777 GO:1990439 MAP kinase serine/threonine phosphatase activity 14/1652 81/18639 0.172839506172839 1.95009416195857 0.0112765179863744 0.132282230224777 GO:0008200 ion channel inhibitor activity 9/1652 43/18639 0.209302325581395 2.36149276423222 0.0117437843748635 0.136451589879366 GO:0042608 T cell receptor binding 4/1652 11/18639 0.363636363636364 4.10279550957517 0.0122064164175347 0.139175962891517 GO:0140031 phosphorylation-dependent protein binding 4/1652 11/18639 0.363636363636364 4.10279550957517 0.0122064164175347 0.139175962891517 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 14/1652 82/18639 0.170731707317073 1.92631252583712 0.0125212721129256 0.140146348419901 GO:0033549 MAP kinase phosphatase activity 14/1652 82/18639 0.170731707317073 1.92631252583712 0.0125212721129256 0.140146348419901 GO:0042277 peptide binding 33/1652 249/18639 0.132530120481928 1.49529595379095 0.0128228476400121 0.142158260405922 GO:0070577 lysine-acetylated histone binding 6/1652 23/18639 0.260869565217391 2.94330982208654 0.0129830819939297 0.142158260405922 GO:0008429 phosphatidylethanolamine binding 5/1652 17/18639 0.294117647058824 3.31843754450933 0.0136053283658158 0.142158260405922 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 5/1652 17/18639 0.294117647058824 3.31843754450933 0.0136053283658158 0.142158260405922 GO:0038191 neuropilin binding 5/1652 17/18639 0.294117647058824 3.31843754450933 0.0136053283658158 0.142158260405922 GO:0001046 core promoter sequence-specific DNA binding 9/1652 44/18639 0.204545454545455 2.30782247413603 0.0136332102192564 0.142158260405922 GO:0016248 channel inhibitor activity 9/1652 44/18639 0.204545454545455 2.30782247413603 0.0136332102192564 0.142158260405922 GO:0019205 nucleobase-containing compound kinase activity 9/1652 44/18639 0.204545454545455 2.30782247413603 0.0136332102192564 0.142158260405922 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 14/1652 83/18639 0.168674698795181 1.90310394118848 0.0138699718070945 0.143401403429282 GO:0019208 phosphatase regulator activity 18/1652 117/18639 0.153846153846154 1.73579810020488 0.0146710984917266 0.150409581175684 GO:0017018 myosin phosphatase activity 14/1652 84/18639 0.166666666666667 1.88044794188862 0.0153279800126451 0.155834463461892 GO:1990841 promoter-specific chromatin binding 12/1652 68/18639 0.176470588235294 1.9910625267056 0.0155437428028606 0.15610510605857 GO:0042605 peptide antigen binding 9/1652 45/18639 0.2 2.25653753026634 0.0157384656108231 0.15610510605857 GO:0141110 transporter inhibitor activity 9/1652 45/18639 0.2 2.25653753026634 0.0157384656108231 0.15610510605857 GO:0030215 semaphorin receptor binding 6/1652 24/18639 0.25 2.82067191283293 0.0160419663007761 0.156569591095575 GO:0140033 acetylation-dependent protein binding 6/1652 24/18639 0.25 2.82067191283293 0.0160419663007761 0.156569591095575 GO:0005164 tumor necrosis factor receptor binding 7/1652 31/18639 0.225806451612903 2.54770366320394 0.0167614798412878 0.158039431636076 GO:0005095 GTPase inhibitor activity 4/1652 12/18639 0.333333333333333 3.76089588377724 0.0170440172474534 0.158039431636076 GO:0035014 phosphatidylinositol 3-kinase regulator activity 4/1652 12/18639 0.333333333333333 3.76089588377724 0.0170440172474534 0.158039431636076 GO:0035259 nuclear glucocorticoid receptor binding 4/1652 12/18639 0.333333333333333 3.76089588377724 0.0170440172474534 0.158039431636076 GO:0035497 cAMP response element binding 4/1652 12/18639 0.333333333333333 3.76089588377724 0.0170440172474534 0.158039431636076 GO:0070008 serine-type exopeptidase activity 4/1652 12/18639 0.333333333333333 3.76089588377724 0.0170440172474534 0.158039431636076 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 43/1652 349/18639 0.123209169054441 1.39013057022139 0.0170993483409525 0.158039431636076 GO:0019887 protein kinase regulator activity 33/1652 255/18639 0.129411764705882 1.46011251958411 0.0177466816919939 0.162789110257388 GO:0140030 modification-dependent protein binding 24/1652 173/18639 0.138728323699422 1.56522834469342 0.0185439662290188 0.168833125368678 GO:0005126 cytokine receptor binding 35/1652 275/18639 0.127272727272727 1.43597842835131 0.0188897578748259 0.170707441535464 GO:0016776 phosphotransferase activity, phosphate group as acceptor 8/1652 39/18639 0.205128205128205 2.31439746693984 0.0192059317081225 0.172288505028746 GO:1901981 phosphatidylinositol phosphate binding 25/1652 185/18639 0.135135135135135 1.52468752045023 0.0222260939657531 0.197925800278969 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/1652 13/18639 0.307692307692308 3.47159620040976 0.0229234842928669 0.199761791694983 GO:0035325 Toll-like receptor binding 4/1652 13/18639 0.307692307692308 3.47159620040976 0.0229234842928669 0.199761791694983 GO:0140852 histone ubiquitin ligase activity 4/1652 13/18639 0.307692307692308 3.47159620040976 0.0229234842928669 0.199761791694983 GO:0140693 molecular condensate scaffold activity 9/1652 48/18639 0.1875 2.1155039346247 0.0234785692778831 0.203147904390194 GO:0001530 lipopolysaccharide binding 8/1652 41/18639 0.195121951219512 2.20150002952814 0.0255048641517948 0.214592650104756 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 8/1652 41/18639 0.195121951219512 2.20150002952814 0.0255048641517948 0.214592650104756 GO:0017080 sodium channel regulator activity 8/1652 41/18639 0.195121951219512 2.20150002952814 0.0255048641517948 0.214592650104756 GO:0042169 SH2 domain binding 8/1652 41/18639 0.195121951219512 2.20150002952814 0.0255048641517948 0.214592650104756 GO:0060590 ATPase regulator activity 9/1652 49/18639 0.183673469387755 2.07233038493848 0.026574425007906 0.222060263764694 GO:0009055 electron transfer activity 17/1652 116/18639 0.146551724137931 1.65349732821241 0.0267964010639716 0.222391899986703 GO:0016791 phosphatase activity 34/1652 273/18639 0.124542124542125 1.40516989064205 0.0271511292046176 0.222734815481711 GO:0030332 cyclin binding 7/1652 34/18639 0.205882352941176 2.32290628115653 0.0272028586121107 0.222734815481711 GO:0001671 ATPase activator activity 6/1652 27/18639 0.222222222222222 2.50726392251816 0.0281071641736763 0.228604935279234 GO:0048487 beta-tubulin binding 8/1652 42/18639 0.19047619047619 2.14908336215842 0.0291396948750841 0.235433296341739 GO:0045499 chemorepellent activity 6/1652 28/18639 0.214285714285714 2.41771878242823 0.0331745631352308 0.264286145636358 GO:0051010 microtubule plus-end binding 5/1652 21/18639 0.238095238095238 2.68635420269803 0.033294925320862 0.264286145636358 GO:0015459 potassium channel regulator activity 10/1652 59/18639 0.169491525423729 1.91231994090368 0.0333607101868845 0.264286145636358 GO:0030544 Hsp70 protein binding 9/1652 51/18639 0.176470588235294 1.9910625267056 0.0336078295350199 0.264526142146608 GO:0003712 transcription coregulator activity 56/1652 495/18639 0.113131313131313 1.27642526964561 0.0344943720919007 0.269763679180249 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 11/1652 68/18639 0.161764705882353 1.82514064948013 0.035932293224355 0.278164211990556 GO:0005484 SNAP receptor activity 7/1652 36/18639 0.194444444444444 2.19385593220339 0.0362013390494973 0.278164211990556 GO:0004721 phosphoprotein phosphatase activity 23/1652 175/18639 0.131428571428571 1.48286751988931 0.0363052262597115 0.278164211990556 GO:0001098 basal transcription machinery binding 10/1652 60/18639 0.166666666666667 1.88044794188862 0.03697354000463 0.278164211990556 GO:0001099 basal RNA polymerase II transcription machinery binding 10/1652 60/18639 0.166666666666667 1.88044794188862 0.03697354000463 0.278164211990556 GO:0004722 protein serine/threonine phosphatase activity 15/1652 103/18639 0.145631067961165 1.64310985213569 0.0377521182696261 0.278164211990556 GO:0017081 chloride channel regulator activity 4/1652 15/18639 0.266666666666667 3.00871670702179 0.0379730707392885 0.278164211990556 GO:0031386 protein tag activity 4/1652 15/18639 0.266666666666667 3.00871670702179 0.0379730707392885 0.278164211990556 GO:0050700 CARD domain binding 4/1652 15/18639 0.266666666666667 3.00871670702179 0.0379730707392885 0.278164211990556 GO:0141047 molecular tag activity 4/1652 15/18639 0.266666666666667 3.00871670702179 0.0379730707392885 0.278164211990556 GO:0070851 growth factor receptor binding 19/1652 139/18639 0.136690647482014 1.54223788039786 0.038076576559363 0.278164211990556 GO:0033691 sialic acid binding 5/1652 22/18639 0.227272727272727 2.56424719348448 0.0400413809990389 0.290776695350163 GO:0005544 calcium-dependent phospholipid binding 9/1652 53/18639 0.169811320754717 1.91592809173557 0.0418294765387659 0.300639244753206 GO:0004715 non-membrane spanning protein tyrosine kinase activity 8/1652 45/18639 0.177777777777778 2.00581113801453 0.0421387793875395 0.300639244753206 GO:0008009 chemokine activity 8/1652 45/18639 0.177777777777778 2.00581113801453 0.0421387793875395 0.300639244753206 GO:0097110 scaffold protein binding 11/1652 70/18639 0.157142857142857 1.7729937737807 0.0432156840051458 0.306529851664406 GO:0008187 poly-pyrimidine tract binding 6/1652 30/18639 0.2 2.25653753026634 0.0449919249462607 0.313657991053931 GO:0031624 ubiquitin conjugating enzyme binding 6/1652 30/18639 0.2 2.25653753026634 0.0449919249462607 0.313657991053931 GO:0070566 adenylyltransferase activity 6/1652 30/18639 0.2 2.25653753026634 0.0449919249462607 0.313657991053931 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/1652 16/18639 0.25 2.82067191283293 0.0471822447194656 0.325370068735728 GO:0030276 clathrin binding 8/1652 46/18639 0.173913043478261 1.96220654805769 0.0472053296444458 0.325370068735728 GO:0005158 insulin receptor binding 5/1652 23/18639 0.217391304347826 2.45275818507211 0.0475575751671248 0.32595641406681 GO:0042393 histone binding 30/1652 247/18639 0.121457489878543 1.37036692121438 0.0478900709226341 0.326401600701752 GO:0005518 collagen binding 11/1652 72/18639 0.152777777777778 1.72374394673124 0.0514541341510588 0.333577140398287 GO:0070325 lipoprotein particle receptor binding 6/1652 31/18639 0.193548387096774 2.18374599703195 0.0517672317714541 0.333577140398287 GO:0001094 TFIID-class transcription factor complex binding 3/1652 10/18639 0.3 3.38480629539952 0.0519505382587497 0.333577140398287 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 3/1652 10/18639 0.3 3.38480629539952 0.0519505382587497 0.333577140398287 GO:0008239 dipeptidyl-peptidase activity 3/1652 10/18639 0.3 3.38480629539952 0.0519505382587497 0.333577140398287 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/1652 10/18639 0.3 3.38480629539952 0.0519505382587497 0.333577140398287 GO:0016783 sulfurtransferase activity 3/1652 10/18639 0.3 3.38480629539952 0.0519505382587497 0.333577140398287 GO:0030957 Tat protein binding 3/1652 10/18639 0.3 3.38480629539952 0.0519505382587497 0.333577140398287 GO:0032395 MHC class II receptor activity 3/1652 10/18639 0.3 3.38480629539952 0.0519505382587497 0.333577140398287 GO:0043208 glycosphingolipid binding 3/1652 10/18639 0.3 3.38480629539952 0.0519505382587497 0.333577140398287 GO:0051880 G-quadruplex DNA binding 3/1652 10/18639 0.3 3.38480629539952 0.0519505382587497 0.333577140398287 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 7/1652 39/18639 0.179487179487179 2.02509778357236 0.0530409258732672 0.338795442750712 GO:0140789 histone phosphatase activity 18/1652 136/18639 0.132352941176471 1.4932968950292 0.0555515261994929 0.346456287071305 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/1652 24/18639 0.208333333333333 2.35055992736077 0.0558511564477429 0.346456287071305 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/1652 24/18639 0.208333333333333 2.35055992736077 0.0558511564477429 0.346456287071305 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 5/1652 24/18639 0.208333333333333 2.35055992736077 0.0558511564477429 0.346456287071305 GO:0070300 phosphatidic acid binding 5/1652 24/18639 0.208333333333333 2.35055992736077 0.0558511564477429 0.346456287071305 GO:0043539 protein serine/threonine kinase activator activity 11/1652 73/18639 0.150684931506849 1.70013101595409 0.0559441709451206 0.346456287071305 GO:0030169 low-density lipoprotein particle binding 4/1652 17/18639 0.235294117647059 2.65475003560746 0.0575136035975117 0.352595961753589 GO:1990226 histone methyltransferase binding 4/1652 17/18639 0.235294117647059 2.65475003560746 0.0575136035975117 0.352595961753589 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 8/1652 48/18639 0.166666666666667 1.88044794188862 0.0584877261372842 0.355368017486877 GO:0070717 poly-purine tract binding 6/1652 32/18639 0.1875 2.1155039346247 0.0591309078277345 0.355368017486877 GO:0071813 lipoprotein particle binding 6/1652 32/18639 0.1875 2.1155039346247 0.0591309078277345 0.355368017486877 GO:0071814 protein-lipid complex binding 6/1652 32/18639 0.1875 2.1155039346247 0.0591309078277345 0.355368017486877 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 7/1652 40/18639 0.175 1.97447033898305 0.0595832951832871 0.356331471194168 GO:0003779 actin binding 49/1652 443/18639 0.110609480812641 1.247972223285 0.0624216360581204 0.371484858492229 GO:0035591 signaling adaptor activity 17/1652 129/18639 0.131782945736434 1.48686581451658 0.0635229805035382 0.376204059292799 GO:0001222 transcription corepressor binding 8/1652 49/18639 0.163265306122449 1.84207145327865 0.0647147117235043 0.377171157794242 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 21/1652 167/18639 0.125748502994012 1.41878108190399 0.0647775006393188 0.377171157794242 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 5/1652 25/18639 0.2 2.25653753026634 0.0649229042104843 0.377171157794242 GO:0120020 cholesterol transfer activity 5/1652 25/18639 0.2 2.25653753026634 0.0649229042104843 0.377171157794242 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7/1652 41/18639 0.170731707317073 1.92631252583712 0.0665994427485944 0.382454021811546 GO:0008432 JUN kinase binding 3/1652 11/18639 0.272727272727273 3.07709663218138 0.0668545839492051 0.382454021811546 GO:0019206 nucleoside kinase activity 3/1652 11/18639 0.272727272727273 3.07709663218138 0.0668545839492051 0.382454021811546 GO:0140416 transcription regulator inhibitor activity 6/1652 33/18639 0.181818181818182 2.05139775478759 0.0670861972685826 0.382454021811546 GO:0061134 peptidase regulator activity 27/1652 226/18639 0.119469026548673 1.34793171055733 0.0682820366980731 0.385413215330316 GO:0004540 RNA nuclease activity 16/1652 121/18639 0.132231404958678 1.49192563984552 0.0685530063333432 0.385413215330316 GO:0051082 unfolded protein binding 16/1652 121/18639 0.132231404958678 1.49192563984552 0.0685530063333432 0.385413215330316 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 4/1652 18/18639 0.222222222222222 2.50726392251816 0.068948604652835 0.38585916365348 GO:0004713 protein tyrosine kinase activity 18/1652 140/18639 0.128571428571429 1.45063126945694 0.069731362793747 0.38845782012955 GO:0032813 tumor necrosis factor receptor superfamily binding 8/1652 50/18639 0.16 1.80523002421308 0.071337066790822 0.393806432057931 GO:0048020 CCR chemokine receptor binding 8/1652 50/18639 0.16 1.80523002421308 0.071337066790822 0.393806432057931 GO:0051879 Hsp90 protein binding 7/1652 42/18639 0.166666666666667 1.88044794188862 0.0740913923232963 0.396590318128845 GO:0001786 phosphatidylserine binding 9/1652 59/18639 0.152542372881356 1.72108794681331 0.0742166919359486 0.396590318128845 GO:0045309 protein phosphorylated amino acid binding 9/1652 59/18639 0.152542372881356 1.72108794681331 0.0742166919359486 0.396590318128845 GO:0070888 E-box binding 9/1652 59/18639 0.152542372881356 1.72108794681331 0.0742166919359486 0.396590318128845 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/1652 26/18639 0.192307692307692 2.1697476252561 0.0747670271882248 0.396590318128845 GO:0005160 transforming growth factor beta receptor binding 5/1652 26/18639 0.192307692307692 2.1697476252561 0.0747670271882248 0.396590318128845 GO:0019865 immunoglobulin binding 5/1652 26/18639 0.192307692307692 2.1697476252561 0.0747670271882248 0.396590318128845 GO:0030247 polysaccharide binding 5/1652 26/18639 0.192307692307692 2.1697476252561 0.0747670271882248 0.396590318128845 GO:0043548 phosphatidylinositol 3-kinase binding 5/1652 26/18639 0.192307692307692 2.1697476252561 0.0747670271882248 0.396590318128845 GO:0004518 nuclease activity 25/1652 209/18639 0.119617224880383 1.34960378604446 0.0760992185659395 0.401909292859075 GO:0000287 magnesium ion binding 27/1652 230/18639 0.117391304347826 1.32448941993894 0.0806723718247734 0.424225403561309 GO:0005520 insulin-like growth factor binding 4/1652 19/18639 0.210526315789474 2.37530266343826 0.0814561782253823 0.424686057414386 GO:0097001 ceramide binding 4/1652 19/18639 0.210526315789474 2.37530266343826 0.0814561782253823 0.424686057414386 GO:0001221 transcription coregulator binding 15/1652 115/18639 0.130434782608696 1.47165491104327 0.0833421545108456 0.427810460266426 GO:0097677 STAT family protein binding 3/1652 12/18639 0.25 2.82067191283293 0.0834581061831224 0.427810460266426 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 3/1652 12/18639 0.25 2.82067191283293 0.0834581061831224 0.427810460266426 GO:1990459 transferrin receptor binding 3/1652 12/18639 0.25 2.82067191283293 0.0834581061831224 0.427810460266426 GO:0051087 protein-folding chaperone binding 17/1652 134/18639 0.126865671641791 1.43138574681074 0.0840447775226201 0.428614323629012 GO:0005154 epidermal growth factor receptor binding 6/1652 35/18639 0.171428571428571 1.93417502594258 0.0847661054682534 0.428614323629012 GO:0000149 SNARE binding 14/1652 106/18639 0.132075471698113 1.49016629357211 0.0849962629149673 0.428614323629012 GO:0008266 poly(U) RNA binding 5/1652 27/18639 0.185185185185185 2.08938660209847 0.0853715415097131 0.428614323629012 GO:0015252 proton channel activity 5/1652 27/18639 0.185185185185185 2.08938660209847 0.0853715415097131 0.428614323629012 GO:0004197 cysteine-type endopeptidase activity 12/1652 88/18639 0.136363636363636 1.53854831609069 0.0875766454134146 0.434944043678892 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 9/1652 61/18639 0.147540983606557 1.66465883380304 0.0877018317582028 0.434944043678892 GO:0019905 syntaxin binding 9/1652 61/18639 0.147540983606557 1.66465883380304 0.0877018317582028 0.434944043678892 GO:0042578 phosphoric ester hydrolase activity 40/1652 363/18639 0.110192837465565 1.24327136653793 0.0888064744417978 0.438639266473657 GO:0019888 protein phosphatase regulator activity 14/1652 107/18639 0.130841121495327 1.47623950578172 0.0902246100734234 0.441636255026715 GO:0003954 NADH dehydrogenase activity 7/1652 44/18639 0.159090909090909 1.79497303543914 0.0904992325874416 0.441636255026715 GO:0043014 alpha-tubulin binding 7/1652 44/18639 0.159090909090909 1.79497303543914 0.0904992325874416 0.441636255026715 GO:0008170 N-methyltransferase activity 13/1652 98/18639 0.13265306122449 1.4966830557889 0.0919907636758095 0.447126421053735 GO:0008168 methyltransferase activity 24/1652 204/18639 0.117647058823529 1.32737501780373 0.0933026595148464 0.44950353115271 GO:0003727 single-stranded RNA binding 12/1652 89/18639 0.134831460674157 1.52126125635933 0.0934895775257798 0.44950353115271 GO:0005246 calcium channel regulator activity 8/1652 53/18639 0.150943396226415 1.70304719265384 0.0935851614039249 0.44950353115271 GO:0016409 palmitoyltransferase activity 6/1652 36/18639 0.166666666666667 1.88044794188862 0.0944790587520048 0.450251764365023 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/1652 36/18639 0.166666666666667 1.88044794188862 0.0944790587520048 0.450251764365023 GO:0019789 SUMO transferase activity 5/1652 28/18639 0.178571428571429 2.01476565202352 0.0967187107215572 0.457352042946898 GO:0046625 sphingolipid binding 5/1652 28/18639 0.178571428571429 2.01476565202352 0.0967187107215572 0.457352042946898 GO:0016741 transferase activity, transferring one-carbon groups 25/1652 215/18639 0.116279069767442 1.31194042457346 0.0976777111181319 0.459165041315714 GO:0022853 active monoatomic ion transmembrane transporter activity 15/1652 118/18639 0.127118644067797 1.43423995567776 0.0986816715409338 0.459165041315714 GO:0051539 4 iron, 4 sulfur cluster binding 7/1652 45/18639 0.155555555555556 1.75508474576271 0.0994077371242657 0.459165041315714 GO:0019210 kinase inhibitor activity 12/1652 90/18639 0.133333333333333 1.5043583535109 0.0996399014595613 0.459165041315714 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 16/1652 128/18639 0.125 1.41033595641646 0.101187714464601 0.459165041315714 GO:0004535 poly(A)-specific ribonuclease activity 3/1652 13/18639 0.230769230769231 2.60369715030732 0.101618492750199 0.459165041315714 GO:0008035 high-density lipoprotein particle binding 3/1652 13/18639 0.230769230769231 2.60369715030732 0.101618492750199 0.459165041315714 GO:0031432 titin binding 3/1652 13/18639 0.230769230769231 2.60369715030732 0.101618492750199 0.459165041315714 GO:0031994 insulin-like growth factor I binding 3/1652 13/18639 0.230769230769231 2.60369715030732 0.101618492750199 0.459165041315714 GO:0035673 oligopeptide transmembrane transporter activity 3/1652 13/18639 0.230769230769231 2.60369715030732 0.101618492750199 0.459165041315714 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/1652 13/18639 0.230769230769231 2.60369715030732 0.101618492750199 0.459165041315714 GO:0071837 HMG box domain binding 3/1652 13/18639 0.230769230769231 2.60369715030732 0.101618492750199 0.459165041315714 GO:0019209 kinase activator activity 18/1652 148/18639 0.121621621621622 1.37221876840521 0.104936539082404 0.472408035721524 GO:0030291 protein serine/threonine kinase inhibitor activity 7/1652 46/18639 0.152173913043478 1.71693072955048 0.108777400005259 0.480591625054561 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/1652 29/18639 0.172413793103448 1.94529097436754 0.10878553186289 0.480591625054561 GO:0051861 glycolipid binding 5/1652 29/18639 0.172413793103448 1.94529097436754 0.10878553186289 0.480591625054561 GO:0106222 lncRNA binding 5/1652 29/18639 0.172413793103448 1.94529097436754 0.10878553186289 0.480591625054561 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4/1652 21/18639 0.19047619047619 2.14908336215842 0.109511862102597 0.480591625054561 GO:0019200 carbohydrate kinase activity 4/1652 21/18639 0.19047619047619 2.14908336215842 0.109511862102597 0.480591625054561 GO:0070182 DNA polymerase binding 4/1652 21/18639 0.19047619047619 2.14908336215842 0.109511862102597 0.480591625054561 GO:0005109 frizzled binding 6/1652 38/18639 0.157894736842105 1.78147699757869 0.115596714303497 0.491403563950511 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6/1652 38/18639 0.157894736842105 1.78147699757869 0.115596714303497 0.491403563950511 GO:0001784 phosphotyrosine residue binding 7/1652 47/18639 0.148936170212766 1.68040028849621 0.118599193340554 0.491403563950511 GO:0051219 phosphoprotein binding 12/1652 93/18639 0.129032258064516 1.45583066468796 0.119507445137855 0.491403563950511 GO:0005161 platelet-derived growth factor receptor binding 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:0008174 mRNA methyltransferase activity 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:0008474 palmitoyl-(protein) hydrolase activity 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:0016530 metallochaperone activity 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:0019763 immunoglobulin receptor activity 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:0061665 SUMO ligase activity 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:0098599 palmitoyl hydrolase activity 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:1901612 cardiolipin binding 3/1652 14/18639 0.214285714285714 2.41771878242823 0.121180666230771 0.491403563950511 GO:0035925 mRNA 3'-UTR AU-rich region binding 5/1652 30/18639 0.166666666666667 1.88044794188862 0.121544253246215 0.491403563950511 GO:0004860 protein kinase inhibitor activity 11/1652 84/18639 0.130952380952381 1.47749481148392 0.122474311304821 0.491403563950511 GO:0051117 ATPase binding 11/1652 84/18639 0.130952380952381 1.47749481148392 0.122474311304821 0.491403563950511 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0032931 histone H3K56 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0043992 histone H3K9 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0043993 histone H3K18 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0043994 histone H3K23 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0043999 histone H2AK5 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0044012 histone H2AK9 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0044014 histone H2BK5 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0044015 histone H2BK12 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0044016 histone H3K4 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0044017 histone H3K27 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0044018 histone H3K36 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0046972 histone H4K16 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0140908 histone H3K122 acetyltransferase activity 4/1652 22/18639 0.181818181818182 2.05139775478759 0.124949746792276 0.491403563950511 GO:0044183 protein folding chaperone 10/1652 75/18639 0.133333333333333 1.5043583535109 0.125136632462752 0.491403563950511 GO:0015631 tubulin binding 41/1652 385/18639 0.106493506493506 1.2015329706613 0.125267629826729 0.491403563950511 GO:0001216 DNA-binding transcription activator activity 51/1652 491/18639 0.103869653767821 1.17192885991429 0.131540883759533 0.514358583931508 GO:0005125 cytokine activity 26/1652 234/18639 0.111111111111111 1.25363196125908 0.136248929945158 0.521743160923018 GO:0004532 RNA exonuclease activity 6/1652 40/18639 0.15 1.69240314769976 0.13886235263599 0.521743160923018 GO:0050997 quaternary ammonium group binding 6/1652 40/18639 0.15 1.69240314769976 0.13886235263599 0.521743160923018 GO:0061791 GTPase motor activity 6/1652 40/18639 0.15 1.69240314769976 0.13886235263599 0.521743160923018 GO:0140662 ATP-dependent protein folding chaperone 6/1652 40/18639 0.15 1.69240314769976 0.13886235263599 0.521743160923018 GO:1990606 membrane scission GTPase motor activity 6/1652 40/18639 0.15 1.69240314769976 0.13886235263599 0.521743160923018 GO:0035401 histone H3Y41 kinase activity 14/1652 115/18639 0.121739130434783 1.37354458364038 0.13911542489784 0.521743160923018 GO:0140801 histone H2AXY142 kinase activity 14/1652 115/18639 0.121739130434783 1.37354458364038 0.13911542489784 0.521743160923018 GO:0004602 glutathione peroxidase activity 4/1652 23/18639 0.173913043478261 1.96220654805769 0.141242835555466 0.521743160923018 GO:0008171 O-methyltransferase activity 4/1652 23/18639 0.173913043478261 1.96220654805769 0.141242835555466 0.521743160923018 GO:0044013 histone H2B acetyltransferase activity 4/1652 23/18639 0.173913043478261 1.96220654805769 0.141242835555466 0.521743160923018 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/1652 23/18639 0.173913043478261 1.96220654805769 0.141242835555466 0.521743160923018 GO:0140103 catalytic activity, acting on a glycoprotein 4/1652 23/18639 0.173913043478261 1.96220654805769 0.141242835555466 0.521743160923018 GO:0004129 cytochrome-c oxidase activity 3/1652 15/18639 0.2 2.25653753026634 0.141982565103641 0.521743160923018 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/1652 15/18639 0.2 2.25653753026634 0.141982565103641 0.521743160923018 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/1652 15/18639 0.2 2.25653753026634 0.141982565103641 0.521743160923018 GO:0005041 low-density lipoprotein particle receptor activity 3/1652 15/18639 0.2 2.25653753026634 0.141982565103641 0.521743160923018 GO:0015929 hexosaminidase activity 3/1652 15/18639 0.2 2.25653753026634 0.141982565103641 0.521743160923018 GO:0016846 carbon-sulfur lyase activity 3/1652 15/18639 0.2 2.25653753026634 0.141982565103641 0.521743160923018 GO:0140776 protein-containing complex destabilizing activity 3/1652 15/18639 0.2 2.25653753026634 0.141982565103641 0.521743160923018 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 50/1652 484/18639 0.103305785123967 1.16556690612931 0.142814715958127 0.523225085492238 GO:0015078 proton transmembrane transporter activity 21/1652 185/18639 0.113513513513514 1.2807375171782 0.143606518673817 0.524550756832504 GO:0031369 translation initiation factor binding 5/1652 32/18639 0.15625 1.76291994552058 0.149005874813686 0.542648260515513 GO:0042287 MHC protein binding 6/1652 41/18639 0.146341463414634 1.65112502214611 0.151250280045258 0.549182564450044 GO:0004519 endonuclease activity 15/1652 127/18639 0.118110236220472 1.3326009037006 0.154426252213016 0.557630321576982 GO:0008234 cysteine-type peptidase activity 21/1652 187/18639 0.112299465240642 1.26703978972174 0.154800741851497 0.557630321576982 GO:0002039 p53 binding 9/1652 69/18639 0.130434782608696 1.47165491104327 0.154948097552948 0.557630321576982 GO:0003924 GTPase activity 35/1652 331/18639 0.105740181268882 1.19303343745199 0.156699340479895 0.562274104074918 GO:0004622 lysophospholipase activity 4/1652 24/18639 0.166666666666667 1.88044794188862 0.15832117137701 0.564771430058341 GO:0043998 histone H2A acetyltransferase activity 4/1652 24/18639 0.166666666666667 1.88044794188862 0.15832117137701 0.564771430058341 GO:0140658 ATP-dependent chromatin remodeler activity 18/1652 158/18639 0.113924050632911 1.28536947926564 0.162049938417852 0.569540358349732 GO:0004857 enzyme inhibitor activity 43/1652 416/18639 0.103365384615385 1.16623934857515 0.162641211945893 0.569540358349732 GO:0019239 deaminase activity 5/1652 33/18639 0.151515151515152 1.70949812898965 0.163634388661026 0.569540358349732 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/1652 16/18639 0.1875 2.1155039346247 0.163859562115374 0.569540358349732 GO:0004708 MAP kinase kinase activity 3/1652 16/18639 0.1875 2.1155039346247 0.163859562115374 0.569540358349732 GO:0005159 insulin-like growth factor receptor binding 3/1652 16/18639 0.1875 2.1155039346247 0.163859562115374 0.569540358349732 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/1652 16/18639 0.1875 2.1155039346247 0.163859562115374 0.569540358349732 GO:0043023 ribosomal large subunit binding 3/1652 16/18639 0.1875 2.1155039346247 0.163859562115374 0.569540358349732 GO:0070411 I-SMAD binding 3/1652 16/18639 0.1875 2.1155039346247 0.163859562115374 0.569540358349732 GO:0030295 protein kinase activator activity 16/1652 139/18639 0.115107913669065 1.29872663612451 0.168948152076147 0.585558936173008 GO:0015026 coreceptor activity 8/1652 61/18639 0.131147540983607 1.47969674115826 0.169660054516028 0.586360528355679 GO:0019902 phosphatase binding 21/1652 190/18639 0.110526315789474 1.24703389830508 0.17247008611381 0.594388432369628 GO:0030159 signaling receptor complex adaptor activity 7/1652 52/18639 0.134615384615385 1.51882333767927 0.17404347996657 0.59812125509638 GO:0003707 nuclear steroid receptor activity 4/1652 25/18639 0.16 1.80523002421308 0.176111317503968 0.601876120422814 GO:0016798 hydrolase activity, acting on glycosyl bonds 15/1652 130/18639 0.115384615384615 1.30184857515366 0.17612276638602 0.601876120422814 GO:0005525 GTP binding 39/1652 378/18639 0.103174603174603 1.16408682116915 0.179249620011996 0.610850660376075 GO:0000510 H3-H4 histone complex chaperone activity 17/1652 151/18639 0.112582781456954 1.27023635809695 0.182725612429428 0.615815599900282 GO:0140584 chromatin extrusion motor activity 17/1652 151/18639 0.112582781456954 1.27023635809695 0.182725612429428 0.615815599900282 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 17/1652 151/18639 0.112582781456954 1.27023635809695 0.182725612429428 0.615815599900282 GO:0140849 ATP-dependent H2AZ histone chaperone activity 17/1652 151/18639 0.112582781456954 1.27023635809695 0.182725612429428 0.615815599900282 GO:0042379 chemokine receptor binding 9/1652 72/18639 0.125 1.41033595641646 0.185242842584898 0.618778635307834 GO:0046982 protein heterodimerization activity 38/1652 369/18639 0.102981029810298 1.16190279336207 0.185982828027727 0.618778635307834 GO:0004550 nucleoside diphosphate kinase activity 3/1652 17/18639 0.176470588235294 1.9910625267056 0.186647981797773 0.618778635307834 GO:0004659 prenyltransferase activity 3/1652 17/18639 0.176470588235294 1.9910625267056 0.186647981797773 0.618778635307834 GO:0032183 SUMO binding 3/1652 17/18639 0.176470588235294 1.9910625267056 0.186647981797773 0.618778635307834 GO:0046965 nuclear retinoid X receptor binding 3/1652 17/18639 0.176470588235294 1.9910625267056 0.186647981797773 0.618778635307834 GO:0015616 DNA translocase activity 17/1652 152/18639 0.111842105263158 1.26187953995157 0.189862329139547 0.624567930448244 GO:0140674 ATP-dependent histone chaperone activity 17/1652 152/18639 0.111842105263158 1.26187953995157 0.189862329139547 0.624567930448244 GO:0016790 thiolester hydrolase activity 6/1652 44/18639 0.136363636363636 1.53854831609069 0.191139355225499 0.624567930448244 GO:0008017 microtubule binding 29/1652 276/18639 0.105072463768116 1.18549978945152 0.192299955255484 0.624567930448244 GO:0000175 3'-5'-RNA exonuclease activity 5/1652 35/18639 0.142857142857143 1.61181252161882 0.194480606312764 0.624567930448244 GO:0034061 DNA polymerase activity 5/1652 35/18639 0.142857142857143 1.61181252161882 0.194480606312764 0.624567930448244 GO:0043015 gamma-tubulin binding 5/1652 35/18639 0.142857142857143 1.61181252161882 0.194480606312764 0.624567930448244 GO:0061631 ubiquitin conjugating enzyme activity 5/1652 35/18639 0.142857142857143 1.61181252161882 0.194480606312764 0.624567930448244 GO:0140566 histone reader activity 5/1652 35/18639 0.142857142857143 1.61181252161882 0.194480606312764 0.624567930448244 GO:0008157 protein phosphatase 1 binding 4/1652 26/18639 0.153846153846154 1.73579810020488 0.19453755210683 0.624567930448244 GO:0008198 ferrous iron binding 4/1652 26/18639 0.153846153846154 1.73579810020488 0.19453755210683 0.624567930448244 GO:0050750 low-density lipoprotein particle receptor binding 4/1652 26/18639 0.153846153846154 1.73579810020488 0.19453755210683 0.624567930448244 GO:0004521 RNA endonuclease activity 9/1652 73/18639 0.123287671232877 1.39101628578062 0.195884097908959 0.62724041850113 GO:0003713 transcription coactivator activity 27/1652 256/18639 0.10546875 1.18997096322639 0.196882114560849 0.627943966165142 GO:0061775 cohesin loader activity 17/1652 153/18639 0.111111111111111 1.25363196125908 0.197133228722336 0.627943966165142 GO:0140463 chromatin-protein adaptor activity 7/1652 54/18639 0.12962962962963 1.46257062146893 0.198871820184166 0.631832345376776 GO:0061135 endopeptidase regulator activity 20/1652 184/18639 0.108695652173913 1.22637909253606 0.199455383291406 0.632040435364975 GO:0016757 glycosyltransferase activity 28/1652 267/18639 0.104868913857678 1.18320319939059 0.200103268941296 0.63245074639477 GO:0000900 mRNA regulatory element binding translation repressor activity 3/1652 18/18639 0.166666666666667 1.88044794188862 0.21018785722676 0.650533925393219 GO:0017075 syntaxin-1 binding 3/1652 18/18639 0.166666666666667 1.88044794188862 0.21018785722676 0.650533925393219 GO:0030228 lipoprotein particle receptor activity 3/1652 18/18639 0.166666666666667 1.88044794188862 0.21018785722676 0.650533925393219 GO:0032393 MHC class I receptor activity 3/1652 18/18639 0.166666666666667 1.88044794188862 0.21018785722676 0.650533925393219 GO:0070628 proteasome binding 3/1652 18/18639 0.166666666666667 1.88044794188862 0.21018785722676 0.650533925393219 GO:1901611 phosphatidylglycerol binding 3/1652 18/18639 0.166666666666667 1.88044794188862 0.21018785722676 0.650533925393219 GO:0005044 scavenger receptor activity 4/1652 27/18639 0.148148148148148 1.67150928167877 0.213522945254155 0.650533925393219 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 4/1652 27/18639 0.148148148148148 1.67150928167877 0.213522945254155 0.650533925393219 GO:0035255 ionotropic glutamate receptor binding 4/1652 27/18639 0.148148148148148 1.67150928167877 0.213522945254155 0.650533925393219 GO:0038024 cargo receptor activity 8/1652 65/18639 0.123076923076923 1.3886384801639 0.215695298274514 0.650533925393219 GO:0120013 lipid transfer activity 8/1652 65/18639 0.123076923076923 1.3886384801639 0.215695298274514 0.650533925393219 GO:0140104 molecular carrier activity 26/1652 249/18639 0.104417670682731 1.17811196359287 0.216911794742578 0.650533925393219 GO:0008276 protein methyltransferase activity 11/1652 95/18639 0.115789473684211 1.30641646489104 0.219181926537421 0.650533925393219 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0008190 eukaryotic initiation factor 4E binding 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0016427 tRNA (cytidine) methyltransferase activity 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0031419 cobalamin binding 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0043422 protein kinase B binding 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0047429 nucleoside triphosphate diphosphatase activity 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0071723 lipopeptide binding 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0140999 histone H3K4 trimethyltransferase activity 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:1905394 retromer complex binding 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:1990757 ubiquitin ligase activator activity 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:1990763 arrestin family protein binding 2/1652 10/18639 0.2 2.25653753026634 0.220221730481475 0.650533925393219 GO:0016922 nuclear receptor binding 15/1652 137/18639 0.109489051094891 1.23533076474435 0.23213932658652 0.674803026175141 GO:0005201 extracellular matrix structural constituent 18/1652 168/18639 0.107142857142857 1.20885939121411 0.232660153050192 0.674803026175141 GO:0036408 histone H3K14 acetyltransferase activity 4/1652 28/18639 0.142857142857143 1.61181252161882 0.232990317676254 0.674803026175141 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/1652 28/18639 0.142857142857143 1.61181252161882 0.232990317676254 0.674803026175141 GO:0042800 histone H3K4 methyltransferase activity 3/1652 19/18639 0.157894736842105 1.78147699757869 0.234325047039519 0.674803026175141 GO:0043395 heparan sulfate proteoglycan binding 3/1652 19/18639 0.157894736842105 1.78147699757869 0.234325047039519 0.674803026175141 GO:0140036 ubiquitin-modified protein reader activity 3/1652 19/18639 0.157894736842105 1.78147699757869 0.234325047039519 0.674803026175141 GO:0061733 protein-lysine-acetyltransferase activity 6/1652 47/18639 0.127659574468085 1.44034310442533 0.23452170745759 0.674803026175141 GO:0061749 forked DNA-dependent helicase activity 6/1652 47/18639 0.127659574468085 1.44034310442533 0.23452170745759 0.674803026175141 GO:0140938 histone H3 methyltransferase activity 6/1652 47/18639 0.127659574468085 1.44034310442533 0.23452170745759 0.674803026175141 GO:1990518 single-stranded 3'-5' DNA helicase activity 6/1652 47/18639 0.127659574468085 1.44034310442533 0.23452170745759 0.674803026175141 GO:0008173 RNA methyltransferase activity 8/1652 67/18639 0.119402985074627 1.34718658523364 0.240316663922123 0.675926032008069 GO:0042054 histone methyltransferase activity 8/1652 67/18639 0.119402985074627 1.34718658523364 0.240316663922123 0.675926032008069 GO:0051540 metal cluster binding 9/1652 77/18639 0.116883116883117 1.3187556995063 0.240841333916011 0.675926032008069 GO:0042887 amide transmembrane transporter activity 5/1652 38/18639 0.131578947368421 1.48456416464891 0.244050676945294 0.675926032008069 GO:0009378 four-way junction helicase activity 6/1652 48/18639 0.125 1.41033595641646 0.249615933270745 0.675926032008069 GO:0032266 phosphatidylinositol-3-phosphate binding 6/1652 48/18639 0.125 1.41033595641646 0.249615933270745 0.675926032008069 GO:0036121 double-stranded DNA helicase activity 6/1652 48/18639 0.125 1.41033595641646 0.249615933270745 0.675926032008069 GO:0043138 3'-5' DNA helicase activity 6/1652 48/18639 0.125 1.41033595641646 0.249615933270745 0.675926032008069 GO:0004725 protein tyrosine phosphatase activity 11/1652 98/18639 0.112244897959184 1.26642412412907 0.249874178199176 0.675926032008069 GO:0003689 DNA clamp loader activity 17/1652 160/18639 0.10625 1.198785562954 0.251495109367112 0.675926032008069 GO:0008408 3'-5' exonuclease activity 7/1652 58/18639 0.120689655172414 1.36170368205728 0.252187189860574 0.675926032008069 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7/1652 58/18639 0.120689655172414 1.36170368205728 0.252187189860574 0.675926032008069 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/1652 29/18639 0.137931034482759 1.55623277949403 0.252863083406393 0.675926032008069 GO:0010484 histone H3 acetyltransferase activity 4/1652 29/18639 0.137931034482759 1.55623277949403 0.252863083406393 0.675926032008069 GO:0097472 cyclin-dependent protein kinase activity 4/1652 29/18639 0.137931034482759 1.55623277949403 0.252863083406393 0.675926032008069 GO:0030145 manganese ion binding 8/1652 68/18639 0.117647058823529 1.32737501780373 0.252968476417221 0.675926032008069 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0002162 dystroglycan binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0003953 NAD+ nucleosidase activity 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0005114 type II transforming growth factor beta receptor binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0005225 volume-sensitive anion channel activity 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0008199 ferric iron binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0010854 adenylate cyclase regulator activity 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0019864 IgG binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0032050 clathrin heavy chain binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0032404 mismatch repair complex binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0034056 estrogen response element binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0034713 type I transforming growth factor beta receptor binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0048185 activin binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0070990 snRNP binding 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0097493 structural molecule activity conferring elasticity 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0140537 transcription regulator activator activity 2/1652 11/18639 0.181818181818182 2.05139775478759 0.254303318599757 0.675926032008069 GO:0001614 purinergic nucleotide receptor activity 3/1652 20/18639 0.15 1.69240314769976 0.258912817046261 0.679298143648254 GO:0016004 phospholipase activator activity 3/1652 20/18639 0.15 1.69240314769976 0.258912817046261 0.679298143648254 GO:0016408 C-acyltransferase activity 3/1652 20/18639 0.15 1.69240314769976 0.258912817046261 0.679298143648254 GO:0016502 nucleotide receptor activity 3/1652 20/18639 0.15 1.69240314769976 0.258912817046261 0.679298143648254 GO:0052745 inositol phosphate phosphatase activity 3/1652 20/18639 0.15 1.69240314769976 0.258912817046261 0.679298143648254 GO:0140939 histone H4 methyltransferase activity 3/1652 20/18639 0.15 1.69240314769976 0.258912817046261 0.679298143648254 GO:0005178 integrin binding 17/1652 161/18639 0.105590062111801 1.19133968989217 0.259709587183287 0.679926387046374 GO:0035254 glutamate receptor binding 6/1652 49/18639 0.122448979591837 1.38155358995899 0.2649735012705 0.687919070577227 GO:0016279 protein-lysine N-methyltransferase activity 8/1652 69/18639 0.115942028985507 1.30813769870513 0.265823608071552 0.687919070577227 GO:0004879 nuclear receptor activity 7/1652 59/18639 0.11864406779661 1.33862395863258 0.266145738780698 0.687919070577227 GO:0031593 polyubiquitin modification-dependent protein binding 7/1652 59/18639 0.11864406779661 1.33862395863258 0.266145738780698 0.687919070577227 GO:0036002 pre-mRNA binding 7/1652 59/18639 0.11864406779661 1.33862395863258 0.266145738780698 0.687919070577227 GO:0070063 RNA polymerase binding 7/1652 59/18639 0.11864406779661 1.33862395863258 0.266145738780698 0.687919070577227 GO:0001965 G-protein alpha-subunit binding 4/1652 30/18639 0.133333333333333 1.5043583535109 0.273065980354112 0.690071138277182 GO:0001968 fibronectin binding 4/1652 30/18639 0.133333333333333 1.5043583535109 0.273065980354112 0.690071138277182 GO:0031210 phosphatidylcholine binding 4/1652 30/18639 0.133333333333333 1.5043583535109 0.273065980354112 0.690071138277182 GO:0043995 histone H4K5 acetyltransferase activity 4/1652 30/18639 0.133333333333333 1.5043583535109 0.273065980354112 0.690071138277182 GO:0043996 histone H4K8 acetyltransferase activity 4/1652 30/18639 0.133333333333333 1.5043583535109 0.273065980354112 0.690071138277182 GO:0043997 histone H4K12 acetyltransferase activity 4/1652 30/18639 0.133333333333333 1.5043583535109 0.273065980354112 0.690071138277182 GO:1902936 phosphatidylinositol bisphosphate binding 12/1652 111/18639 0.108108108108108 1.21975001636019 0.278290023537245 0.690071138277182 GO:0016278 lysine N-methyltransferase activity 8/1652 70/18639 0.114285714285714 1.28945001729505 0.278863571182626 0.690071138277182 GO:0098531 ligand-modulated transcription factor activity 7/1652 60/18639 0.116666666666667 1.31631355932203 0.280308760016532 0.690071138277182 GO:0005006 epidermal growth factor receptor activity 6/1652 50/18639 0.12 1.35392251815981 0.280561932217251 0.690071138277182 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/1652 21/18639 0.142857142857143 1.61181252161882 0.283812976203538 0.690071138277182 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/1652 21/18639 0.142857142857143 1.61181252161882 0.283812976203538 0.690071138277182 GO:0140713 histone chaperone activity 17/1652 164/18639 0.103658536585366 1.16954689068682 0.284930883332099 0.690071138277182 GO:0072341 modified amino acid binding 10/1652 91/18639 0.10989010989011 1.23985578586063 0.285562391105099 0.690071138277182 GO:0019001 guanyl nucleotide binding 39/1652 400/18639 0.0975 1.10006204600484 0.288296974924442 0.690071138277182 GO:0032561 guanyl ribonucleotide binding 39/1652 400/18639 0.0975 1.10006204600484 0.288296974924442 0.690071138277182 GO:0003720 telomerase activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0004000 adenosine deaminase activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0004032 aldose reductase (NADPH) activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0004126 cytidine deaminase activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0004300 enoyl-CoA hydratase activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0005025 transforming growth factor beta receptor activity, type I 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0005026 transforming growth factor beta receptor activity, type II 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0005049 nuclear export signal receptor activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0015166 polyol transmembrane transporter activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0015269 calcium-activated potassium channel activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0016273 arginine N-methyltransferase activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0016274 protein-arginine N-methyltransferase activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0016361 activin receptor activity, type I 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0016362 activin receptor activity, type II 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0017002 activin receptor activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0034452 dynactin binding 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0035197 siRNA binding 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0045295 gamma-catenin binding 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:1990817 poly(A) RNA polymerase activity 2/1652 12/18639 0.166666666666667 1.88044794188862 0.288472361083084 0.690071138277182 GO:0008238 exopeptidase activity 11/1652 102/18639 0.107843137254902 1.21676043298675 0.292942442757096 0.69939291617154 GO:0070273 phosphatidylinositol-4-phosphate binding 4/1652 31/18639 0.129032258064516 1.45583066468796 0.293525694299591 0.699416693448244 GO:0016597 amino acid binding 6/1652 51/18639 0.117647058823529 1.32737501780373 0.296348734778552 0.703669179339071 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/1652 41/18639 0.121951219512195 1.37593751845509 0.296463900147773 0.703669179339071 GO:0004386 helicase activity 16/1652 155/18639 0.103225806451613 1.16466453175037 0.298535777050085 0.707210966992435 GO:0031406 carboxylic acid binding 19/1652 187/18639 0.101604278074866 1.14636933355777 0.300134936501201 0.709621361495087 GO:0015399 primary active transmembrane transporter activity 17/1652 166/18639 0.102409638554217 1.15545596429301 0.302179643707864 0.713073820741961 GO:0051015 actin filament binding 21/1652 209/18639 0.100478468899522 1.13366718027735 0.305509597943786 0.717947507815994 GO:0140597 protein carrier chaperone 19/1652 188/18639 0.101063829787234 1.14027162433672 0.308338229192914 0.717947507815994 GO:0008093 cytoskeletal anchor activity 3/1652 22/18639 0.136363636363636 1.53854831609069 0.308896644005316 0.717947507815994 GO:0008649 rRNA methyltransferase activity 3/1652 22/18639 0.136363636363636 1.53854831609069 0.308896644005316 0.717947507815994 GO:0008970 phospholipase A1 activity 3/1652 22/18639 0.136363636363636 1.53854831609069 0.308896644005316 0.717947507815994 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/1652 22/18639 0.136363636363636 1.53854831609069 0.308896644005316 0.717947507815994 GO:0140035 ubiquitin-like protein reader activity 3/1652 22/18639 0.136363636363636 1.53854831609069 0.308896644005316 0.717947507815994 GO:0051213 dioxygenase activity 10/1652 93/18639 0.10752688172043 1.2131922205733 0.308952820986391 0.717947507815994 GO:0008094 ATP-dependent activity, acting on DNA 21/1652 210/18639 0.1 1.12826876513317 0.313317502958953 0.724964934660593 GO:0043425 bHLH transcription factor binding 4/1652 32/18639 0.125 1.41033595641646 0.314171382797578 0.724964934660593 GO:0004520 DNA endonuclease activity 5/1652 42/18639 0.119047619047619 1.34317710134901 0.314349549537257 0.724964934660593 GO:0043175 RNA polymerase core enzyme binding 5/1652 42/18639 0.119047619047619 1.34317710134901 0.314349549537257 0.724964934660593 GO:0043177 organic acid binding 19/1652 189/18639 0.100529100529101 1.13423844113917 0.316607202205687 0.725800490517817 GO:0016887 ATP hydrolysis activity 40/1652 417/18639 0.0959232613908873 1.08227219677043 0.322405361092092 0.725800490517817 GO:0003964 RNA-directed DNA polymerase activity 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0008253 5'-nucleotidase activity 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0008417 fucosyltransferase activity 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0017154 semaphorin receptor activity 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0019855 calcium channel inhibitor activity 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0039706 co-receptor binding 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0046975 histone H3K36 methyltransferase activity 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0061459 L-arginine transmembrane transporter activity 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0070123 transforming growth factor beta receptor activity, type III 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0140333 glycerophospholipid flippase activity 2/1652 13/18639 0.153846153846154 1.73579810020488 0.322445791689063 0.725800490517817 GO:0005507 copper ion binding 7/1652 63/18639 0.111111111111111 1.25363196125908 0.323783107089732 0.727468491067169 GO:0004527 exonuclease activity 9/1652 84/18639 0.107142857142857 1.20885939121411 0.326581184859039 0.731730477860321 GO:0034212 protein N-acetyltransferase activity 6/1652 53/18639 0.113207547169811 1.27728539449038 0.328388546054539 0.731730477860321 GO:0038064 collagen receptor activity 6/1652 53/18639 0.113207547169811 1.27728539449038 0.328388546054539 0.731730477860321 GO:0051018 protein kinase A binding 6/1652 53/18639 0.113207547169811 1.27728539449038 0.328388546054539 0.731730477860321 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/1652 43/18639 0.116279069767442 1.31194042457346 0.332367161037094 0.731730477860321 GO:0008375 acetylglucosaminyltransferase activity 5/1652 43/18639 0.116279069767442 1.31194042457346 0.332367161037094 0.731730477860321 GO:0048156 tau protein binding 5/1652 43/18639 0.116279069767442 1.31194042457346 0.332367161037094 0.731730477860321 GO:0003887 DNA-directed DNA polymerase activity 3/1652 23/18639 0.130434782608696 1.47165491104327 0.334044715272794 0.731730477860321 GO:0005283 amino acid:sodium symporter activity 3/1652 23/18639 0.130434782608696 1.47165491104327 0.334044715272794 0.731730477860321 GO:0042171 lysophosphatidic acid acyltransferase activity 3/1652 23/18639 0.130434782608696 1.47165491104327 0.334044715272794 0.731730477860321 GO:0071617 lysophospholipid acyltransferase activity 3/1652 23/18639 0.130434782608696 1.47165491104327 0.334044715272794 0.731730477860321 GO:0140102 catalytic activity, acting on a rRNA 3/1652 23/18639 0.130434782608696 1.47165491104327 0.334044715272794 0.731730477860321 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4/1652 33/18639 0.121212121212121 1.36759850319172 0.334935106126757 0.731730477860321 GO:0071889 14-3-3 protein binding 4/1652 33/18639 0.121212121212121 1.36759850319172 0.334935106126757 0.731730477860321 GO:0019783 ubiquitin-like protein peptidase activity 13/1652 127/18639 0.102362204724409 1.15492078320718 0.335276505839278 0.731730477860321 GO:0042826 histone deacetylase binding 13/1652 127/18639 0.102362204724409 1.15492078320718 0.335276505839278 0.731730477860321 GO:0008013 beta-catenin binding 11/1652 106/18639 0.10377358490566 1.17084494494952 0.337859147869898 0.735430880012125 GO:0140098 catalytic activity, acting on RNA 37/1652 387/18639 0.0956072351421189 1.07870657131595 0.338177642366231 0.735430880012125 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 6/1652 54/18639 0.111111111111111 1.25363196125908 0.344578136788336 0.74396187302621 GO:0004896 cytokine receptor activity 10/1652 96/18639 0.104166666666667 1.17527996368039 0.344810652522745 0.74396187302621 GO:0033218 amide binding 24/1652 247/18639 0.097165991902834 1.0962935369715 0.348866109160386 0.74396187302621 GO:0001223 transcription coactivator binding 5/1652 44/18639 0.113636363636364 1.28212359674224 0.350473289987299 0.74396187302621 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 9/1652 86/18639 0.104651162790698 1.18074638211611 0.352148944971505 0.74396187302621 GO:0008175 tRNA methyltransferase activity 4/1652 34/18639 0.117647058823529 1.32737501780373 0.355752172784709 0.74396187302621 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/1652 34/18639 0.117647058823529 1.32737501780373 0.355752172784709 0.74396187302621 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/1652 34/18639 0.117647058823529 1.32737501780373 0.355752172784709 0.74396187302621 GO:0005313 L-glutamate transmembrane transporter activity 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0005545 1-phosphatidylinositol binding 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0015926 glucosidase activity 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0019992 diacylglycerol binding 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0031404 chloride ion binding 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0032036 myosin heavy chain binding 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0042043 neurexin family protein binding 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0044548 S100 protein binding 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0046030 inositol trisphosphate phosphatase activity 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0098821 BMP receptor activity 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:1990825 sequence-specific mRNA binding 2/1652 14/18639 0.142857142857143 1.61181252161882 0.355989979265445 0.74396187302621 GO:0042625 ATPase-coupled ion transmembrane transporter activity 3/1652 24/18639 0.125 1.41033595641646 0.359148078686478 0.74396187302621 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 3/1652 24/18639 0.125 1.41033595641646 0.359148078686478 0.74396187302621 GO:0046961 proton-transporting ATPase activity, rotational mechanism 3/1652 24/18639 0.125 1.41033595641646 0.359148078686478 0.74396187302621 GO:0048027 mRNA 5'-UTR binding 3/1652 24/18639 0.125 1.41033595641646 0.359148078686478 0.74396187302621 GO:0060229 lipase activator activity 3/1652 24/18639 0.125 1.41033595641646 0.359148078686478 0.74396187302621 GO:0070840 dynein complex binding 3/1652 24/18639 0.125 1.41033595641646 0.359148078686478 0.74396187302621 GO:0017022 myosin binding 8/1652 76/18639 0.105263157894737 1.18765133171913 0.359931684585113 0.74396187302621 GO:0051536 iron-sulfur cluster binding 8/1652 76/18639 0.105263157894737 1.18765133171913 0.359931684585113 0.74396187302621 GO:0098631 cell adhesion mediator activity 8/1652 76/18639 0.105263157894737 1.18765133171913 0.359931684585113 0.74396187302621 GO:0004843 cysteine-type deubiquitinase activity 11/1652 108/18639 0.101851851851852 1.14916263115416 0.360796966040837 0.74396187302621 GO:0098632 cell-cell adhesion mediator activity 6/1652 55/18639 0.109090909090909 1.23083865287255 0.360839567481015 0.74396187302621 GO:0140097 catalytic activity, acting on DNA 32/1652 336/18639 0.0952380952380952 1.07454168107921 0.361004449861899 0.74396187302621 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 13/1652 130/18639 0.1 1.12826876513317 0.366661522483986 0.754345796678689 GO:0003724 RNA helicase activity 8/1652 77/18639 0.103896103896104 1.17222728845005 0.373739261474284 0.767612624576812 GO:0010485 histone H4 acetyltransferase activity 4/1652 35/18639 0.114285714285714 1.28945001729505 0.376561407168186 0.771504585579081 GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/1652 88/18639 0.102272727272727 1.15391123706802 0.377969427656434 0.771504585579081 GO:0003735 structural constituent of ribosome 17/1652 175/18639 0.0971428571428571 1.0960325147008 0.382948418677013 0.771504585579081 GO:0016500 protein-hormone receptor activity 7/1652 67/18639 0.104477611940299 1.17878826207943 0.383155242438205 0.771504585579081 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/1652 67/18639 0.104477611940299 1.17878826207943 0.383155242438205 0.771504585579081 GO:0050840 extracellular matrix binding 7/1652 67/18639 0.104477611940299 1.17878826207943 0.383155242438205 0.771504585579081 GO:0008139 nuclear localization sequence binding 3/1652 25/18639 0.12 1.35392251815981 0.384107637029547 0.771504585579081 GO:0017056 structural constituent of nuclear pore 3/1652 25/18639 0.12 1.35392251815981 0.384107637029547 0.771504585579081 GO:0019706 protein-cysteine S-palmitoyltransferase activity 3/1652 25/18639 0.12 1.35392251815981 0.384107637029547 0.771504585579081 GO:0019707 protein-cysteine S-acyltransferase activity 3/1652 25/18639 0.12 1.35392251815981 0.384107637029547 0.771504585579081 GO:0042974 nuclear retinoic acid receptor binding 3/1652 25/18639 0.12 1.35392251815981 0.384107637029547 0.771504585579081 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/1652 25/18639 0.12 1.35392251815981 0.384107637029547 0.771504585579081 GO:0003697 single-stranded DNA binding 12/1652 121/18639 0.0991735537190083 1.11894422988414 0.386077215603095 0.771504585579081 GO:0004180 carboxypeptidase activity 5/1652 46/18639 0.108695652173913 1.22637909253606 0.386784849280424 0.771504585579081 GO:0019199 transmembrane receptor protein kinase activity 8/1652 78/18639 0.102564102564103 1.15719873346992 0.387582394993953 0.771504585579081 GO:0000774 adenyl-nucleotide exchange factor activity 2/1652 15/18639 0.133333333333333 1.5043583535109 0.388914196828799 0.771504585579081 GO:0004559 alpha-mannosidase activity 2/1652 15/18639 0.133333333333333 1.5043583535109 0.388914196828799 0.771504585579081 GO:0004953 icosanoid receptor activity 2/1652 15/18639 0.133333333333333 1.5043583535109 0.388914196828799 0.771504585579081 GO:0008252 nucleotidase activity 2/1652 15/18639 0.133333333333333 1.5043583535109 0.388914196828799 0.771504585579081 GO:0033130 acetylcholine receptor binding 2/1652 15/18639 0.133333333333333 1.5043583535109 0.388914196828799 0.771504585579081 GO:0120283 protein serine/threonine kinase binding 2/1652 15/18639 0.133333333333333 1.5043583535109 0.388914196828799 0.771504585579081 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 9/1652 89/18639 0.101123595505618 1.1409459422695 0.390937065705595 0.773003598315763 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 9/1652 89/18639 0.101123595505618 1.1409459422695 0.390937065705595 0.773003598315763 GO:0004601 peroxidase activity 6/1652 57/18639 0.105263157894737 1.18765133171913 0.393458793635772 0.776730951837608 GO:0001664 G protein-coupled receptor binding 28/1652 297/18639 0.0942760942760943 1.06368772470467 0.394442394143154 0.777414734821725 GO:0000993 RNA polymerase II complex binding 4/1652 36/18639 0.111111111111111 1.25363196125908 0.397305347042033 0.780535464398197 GO:0045505 dynein intermediate chain binding 4/1652 36/18639 0.111111111111111 1.25363196125908 0.397305347042033 0.780535464398197 GO:0019955 cytokine binding 14/1652 144/18639 0.0972222222222222 1.09692796610169 0.399448092692693 0.783483397242902 GO:0008186 ATP-dependent activity, acting on RNA 8/1652 79/18639 0.10126582278481 1.14255064823612 0.401443333612543 0.786133012852813 GO:0140793 histone H2AXY142 phosphatase activity 9/1652 90/18639 0.1 1.12826876513317 0.403923457658107 0.789722144780274 GO:0005504 fatty acid binding 5/1652 47/18639 0.106382978723404 1.20028592035444 0.404911413783143 0.790387079704695 GO:0043022 ribosome binding 11/1652 112/18639 0.0982142857142857 1.10812110861294 0.40720189594014 0.791524079962212 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1652 26/18639 0.115384615384615 1.30184857515366 0.408834169845554 0.791524079962212 GO:0008143 poly(A) binding 3/1652 26/18639 0.115384615384615 1.30184857515366 0.408834169845554 0.791524079962212 GO:0034237 protein kinase A regulatory subunit binding 3/1652 26/18639 0.115384615384615 1.30184857515366 0.408834169845554 0.791524079962212 GO:0052742 phosphatidylinositol kinase activity 3/1652 26/18639 0.115384615384615 1.30184857515366 0.408834169845554 0.791524079962212 GO:0017116 single-stranded DNA helicase activity 6/1652 58/18639 0.103448275862069 1.16717458462052 0.409759363302141 0.791524079962212 GO:0008080 N-acetyltransferase activity 7/1652 69/18639 0.101449275362319 1.14462048636699 0.413028541185614 0.791524079962212 GO:0048306 calcium-dependent protein binding 8/1652 80/18639 0.1 1.12826876513317 0.415304728619797 0.791524079962212 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 9/1652 91/18639 0.0989010989010989 1.11587020727457 0.41691430642612 0.791524079962212 GO:0022829 wide pore channel activity 4/1652 37/18639 0.108108108108108 1.21975001636019 0.417930378228269 0.791524079962212 GO:0043394 proteoglycan binding 4/1652 37/18639 0.108108108108108 1.21975001636019 0.417930378228269 0.791524079962212 GO:0003688 DNA replication origin binding 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0005024 transforming growth factor beta receptor activity 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0005149 interleukin-1 receptor binding 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0005521 lamin binding 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0015923 mannosidase activity 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0016722 oxidoreductase activity, acting on metal ions 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0019841 retinol binding 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0055102 lipase inhibitor activity 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0097027 ubiquitin-protein transferase activator activity 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0140327 flippase activity 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0140328 floppase activity 2/1652 16/18639 0.125 1.41033595641646 0.421064858930718 0.791524079962212 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/1652 59/18639 0.101694915254237 1.14739196454221 0.42601750947438 0.79960209470576 GO:0030971 receptor tyrosine kinase binding 8/1652 81/18639 0.0987654320987654 1.11433952111918 0.429149681977593 0.804243643644644 GO:0002020 protease binding 13/1652 136/18639 0.0955882352941176 1.07849220196553 0.430390127184708 0.805213420956428 GO:0004364 glutathione transferase activity 3/1652 27/18639 0.111111111111111 1.25363196125908 0.433248072919478 0.805213420956428 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/1652 27/18639 0.111111111111111 1.25363196125908 0.433248072919478 0.805213420956428 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1652 27/18639 0.111111111111111 1.25363196125908 0.433248072919478 0.805213420956428 GO:0042162 telomeric DNA binding 4/1652 38/18639 0.105263157894737 1.18765133171913 0.438386813673326 0.805213420956428 GO:0043531 ADP binding 4/1652 38/18639 0.105263157894737 1.18765133171913 0.438386813673326 0.805213420956428 GO:0005004 GPI-linked ephrin receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0005008 hepatocyte growth factor receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0005009 insulin receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0005011 macrophage colony-stimulating factor receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0005018 platelet-derived growth factor alpha-receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0005020 stem cell factor receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0008288 boss receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0036332 placental growth factor receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0038062 protein tyrosine kinase collagen receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0060175 brain-derived neurotrophic factor receptor activity 5/1652 49/18639 0.102040816326531 1.15129465829916 0.440923064901407 0.805213420956428 GO:0101005 deubiquitinase activity 11/1652 115/18639 0.0956521739130435 1.07921360143173 0.442138712812659 0.805213420956428 GO:0004714 transmembrane receptor protein tyrosine kinase activity 6/1652 60/18639 0.1 1.12826876513317 0.442207370525252 0.805213420956428 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6/1652 60/18639 0.1 1.12826876513317 0.442207370525252 0.805213420956428 GO:0004549 tRNA-specific ribonuclease activity 2/1652 17/18639 0.117647058823529 1.32737501780373 0.452320442548443 0.81271125170707 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/1652 17/18639 0.117647058823529 1.32737501780373 0.452320442548443 0.81271125170707 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/1652 17/18639 0.117647058823529 1.32737501780373 0.452320442548443 0.81271125170707 GO:0005092 GDP-dissociation inhibitor activity 2/1652 17/18639 0.117647058823529 1.32737501780373 0.452320442548443 0.81271125170707 GO:0017110 nucleoside diphosphate phosphatase activity 2/1652 17/18639 0.117647058823529 1.32737501780373 0.452320442548443 0.81271125170707 GO:0019198 transmembrane receptor protein phosphatase activity 2/1652 17/18639 0.117647058823529 1.32737501780373 0.452320442548443 0.81271125170707 GO:0045125 bioactive lipid receptor activity 2/1652 17/18639 0.117647058823529 1.32737501780373 0.452320442548443 0.81271125170707 GO:0051787 misfolded protein binding 2/1652 17/18639 0.117647058823529 1.32737501780373 0.452320442548443 0.81271125170707 GO:0070403 NAD+ binding 2/1652 17/18639 0.117647058823529 1.32737501780373 0.452320442548443 0.81271125170707 GO:0030165 PDZ domain binding 8/1652 83/18639 0.0963855421686747 1.08748796639342 0.456725179733732 0.81583670788664 GO:0046875 ephrin receptor binding 3/1652 28/18639 0.107142857142857 1.20885939121411 0.457279003548665 0.81583670788664 GO:0051019 mitogen-activated protein kinase binding 3/1652 28/18639 0.107142857142857 1.20885939121411 0.457279003548665 0.81583670788664 GO:0000217 DNA secondary structure binding 4/1652 39/18639 0.102564102564103 1.15719873346992 0.458628923703971 0.81583670788664 GO:0005007 fibroblast growth factor receptor activity 5/1652 50/18639 0.1 1.12826876513317 0.45874096853298 0.81583670788664 GO:0005017 platelet-derived growth factor receptor activity 5/1652 50/18639 0.1 1.12826876513317 0.45874096853298 0.81583670788664 GO:0005019 platelet-derived growth factor beta-receptor activity 5/1652 50/18639 0.1 1.12826876513317 0.45874096853298 0.81583670788664 GO:0140767 enzyme-substrate adaptor activity 13/1652 139/18639 0.0935251798561151 1.05521539185117 0.462306342651222 0.820980695828952 GO:0015179 L-amino acid transmembrane transporter activity 6/1652 62/18639 0.0967741935483871 1.09187299851597 0.474284955210002 0.832752700382825 GO:0005010 insulin-like growth factor receptor activity 5/1652 51/18639 0.0980392156862745 1.10614584816978 0.476392298288896 0.832752700382825 GO:0005021 vascular endothelial growth factor receptor activity 5/1652 51/18639 0.0980392156862745 1.10614584816978 0.476392298288896 0.832752700382825 GO:0005030 neurotrophin receptor activity 5/1652 51/18639 0.0980392156862745 1.10614584816978 0.476392298288896 0.832752700382825 GO:0005048 signal sequence binding 5/1652 51/18639 0.0980392156862745 1.10614584816978 0.476392298288896 0.832752700382825 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/1652 40/18639 0.1 1.12826876513317 0.478614923883691 0.832752700382825 GO:0030331 nuclear estrogen receptor binding 4/1652 40/18639 0.1 1.12826876513317 0.478614923883691 0.832752700382825 GO:0005416 amino acid:monoatomic cation symporter activity 3/1652 29/18639 0.103448275862069 1.16717458462052 0.480865455872773 0.832752700382825 GO:0016417 S-acyltransferase activity 3/1652 29/18639 0.103448275862069 1.16717458462052 0.480865455872773 0.832752700382825 GO:0043236 laminin binding 3/1652 29/18639 0.103448275862069 1.16717458462052 0.480865455872773 0.832752700382825 GO:0016407 acetyltransferase activity 9/1652 96/18639 0.09375 1.05775196731235 0.481458737106603 0.832752700382825 GO:0000400 four-way junction DNA binding 2/1652 18/18639 0.111111111111111 1.25363196125908 0.482587015713654 0.832752700382825 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/1652 18/18639 0.111111111111111 1.25363196125908 0.482587015713654 0.832752700382825 GO:0015172 acidic amino acid transmembrane transporter activity 2/1652 18/18639 0.111111111111111 1.25363196125908 0.482587015713654 0.832752700382825 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/1652 18/18639 0.111111111111111 1.25363196125908 0.482587015713654 0.832752700382825 GO:0031690 adrenergic receptor binding 2/1652 18/18639 0.111111111111111 1.25363196125908 0.482587015713654 0.832752700382825 GO:0034185 apolipoprotein binding 2/1652 18/18639 0.111111111111111 1.25363196125908 0.482587015713654 0.832752700382825 GO:0035615 clathrin adaptor activity 2/1652 18/18639 0.111111111111111 1.25363196125908 0.482587015713654 0.832752700382825 GO:0050811 GABA receptor binding 2/1652 18/18639 0.111111111111111 1.25363196125908 0.482587015713654 0.832752700382825 GO:0098641 cadherin binding involved in cell-cell adhesion 2/1652 18/18639 0.111111111111111 1.25363196125908 0.482587015713654 0.832752700382825 GO:0017171 serine hydrolase activity 18/1652 198/18639 0.0909090909090909 1.02569887739379 0.491352009883375 0.846680017030675 GO:0001727 lipid kinase activity 4/1652 41/18639 0.0975609756097561 1.10075001476407 0.498306926449737 0.855041420912347 GO:0015175 neutral L-amino acid transmembrane transporter activity 4/1652 41/18639 0.0975609756097561 1.10075001476407 0.498306926449737 0.855041420912347 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/1652 41/18639 0.0975609756097561 1.10075001476407 0.498306926449737 0.855041420912347 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1652 30/18639 0.1 1.12826876513317 0.503954286485958 0.860040018592292 GO:0048019 receptor antagonist activity 3/1652 30/18639 0.1 1.12826876513317 0.503954286485958 0.860040018592292 GO:0043021 ribonucleoprotein complex binding 16/1652 177/18639 0.0903954802259887 1.01990396848196 0.505525607642141 0.860040018592292 GO:0005003 ephrin receptor activity 5/1652 53/18639 0.0943396226415094 1.06440449540865 0.511084194735988 0.860040018592292 GO:0005005 transmembrane-ephrin receptor activity 5/1652 53/18639 0.0943396226415094 1.06440449540865 0.511084194735988 0.860040018592292 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:0016918 retinal binding 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:0031420 alkali metal ion binding 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:0034987 immunoglobulin receptor binding 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:0042577 lipid phosphatase activity 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:0042834 peptidoglycan binding 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:0046527 glucosyltransferase activity 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:0070003 threonine-type peptidase activity 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:1990380 K48-linked deubiquitinase activity 2/1652 19/18639 0.105263157894737 1.18765133171913 0.511794306145905 0.860040018592292 GO:0019903 protein phosphatase binding 13/1652 144/18639 0.0902777777777778 1.018575968523 0.514882766454225 0.862886523197155 GO:0005319 lipid transporter activity 16/1652 178/18639 0.0898876404494382 1.01417417090622 0.514902777776663 0.862886523197155 GO:0004402 histone acetyltransferase activity 4/1652 42/18639 0.0952380952380952 1.07454168107921 0.517670860861577 0.863965048223151 GO:0019894 kinesin binding 4/1652 42/18639 0.0952380952380952 1.07454168107921 0.517670860861577 0.863965048223151 GO:0042056 chemoattractant activity 4/1652 42/18639 0.0952380952380952 1.07454168107921 0.517670860861577 0.863965048223151 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 11/1652 122/18639 0.0901639344262295 1.0172915095463 0.522505737034573 0.870842895057622 GO:0016411 acylglycerol O-acyltransferase activity 3/1652 31/18639 0.0967741935483871 1.09187299851597 0.526500207077354 0.873918711067173 GO:0016878 acid-thiol ligase activity 3/1652 31/18639 0.0967741935483871 1.09187299851597 0.526500207077354 0.873918711067173 GO:0047499 calcium-independent phospholipase A2 activity 3/1652 31/18639 0.0967741935483871 1.09187299851597 0.526500207077354 0.873918711067173 GO:0050661 NADP binding 5/1652 54/18639 0.0925925925925926 1.04469330104923 0.528074608812279 0.874153355157368 GO:0051287 NAD binding 5/1652 54/18639 0.0925925925925926 1.04469330104923 0.528074608812279 0.874153355157368 GO:0000339 RNA cap binding 2/1652 20/18639 0.1 1.12826876513317 0.539892249379198 0.88769345585259 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1652 20/18639 0.1 1.12826876513317 0.539892249379198 0.88769345585259 GO:0010851 cyclase regulator activity 2/1652 20/18639 0.1 1.12826876513317 0.539892249379198 0.88769345585259 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1652 20/18639 0.1 1.12826876513317 0.539892249379198 0.88769345585259 GO:0042288 MHC class I protein binding 2/1652 20/18639 0.1 1.12826876513317 0.539892249379198 0.88769345585259 GO:0008374 O-acyltransferase activity 5/1652 55/18639 0.0909090909090909 1.02569887739379 0.544798112945405 0.894554102009952 GO:0022884 macromolecule transmembrane transporter activity 3/1652 32/18639 0.09375 1.05775196731235 0.548465257864918 0.895753165455421 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1652 32/18639 0.09375 1.05775196731235 0.548465257864918 0.895753165455421 GO:0047498 calcium-dependent phospholipase A2 activity 3/1652 32/18639 0.09375 1.05775196731235 0.548465257864918 0.895753165455421 GO:0140142 nucleocytoplasmic carrier activity 3/1652 32/18639 0.09375 1.05775196731235 0.548465257864918 0.895753165455421 GO:0030547 signaling receptor inhibitor activity 4/1652 44/18639 0.0909090909090909 1.02569887739379 0.555296676390741 0.898698842054223 GO:0008236 serine-type peptidase activity 17/1652 194/18639 0.0876288659793814 0.988689124085769 0.556768988031473 0.898698842054223 GO:0030170 pyridoxal phosphate binding 5/1652 56/18639 0.0892857142857143 1.00738282601176 0.561234905951672 0.898698842054223 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 20/1652 229/18639 0.0873362445414847 0.985387567801897 0.561868184488065 0.898698842054223 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1652 21/18639 0.0952380952380952 1.07454168107921 0.566847962345058 0.898698842054223 GO:0015174 basic amino acid transmembrane transporter activity 2/1652 21/18639 0.0952380952380952 1.07454168107921 0.566847962345058 0.898698842054223 GO:0035613 RNA stem-loop binding 2/1652 21/18639 0.0952380952380952 1.07454168107921 0.566847962345058 0.898698842054223 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/1652 21/18639 0.0952380952380952 1.07454168107921 0.566847962345058 0.898698842054223 GO:0061891 calcium ion sensor activity 2/1652 21/18639 0.0952380952380952 1.07454168107921 0.566847962345058 0.898698842054223 GO:0140312 cargo adaptor activity 2/1652 21/18639 0.0952380952380952 1.07454168107921 0.566847962345058 0.898698842054223 GO:0019956 chemokine binding 3/1652 33/18639 0.0909090909090909 1.02569887739379 0.569818273038734 0.898698842054223 GO:0005516 calmodulin binding 18/1652 207/18639 0.0869565217391304 0.981103274028845 0.569908175971485 0.898698842054223 GO:0140303 intramembrane lipid transporter activity 4/1652 45/18639 0.0888888888888889 1.00290556900726 0.573508453379725 0.898698842054223 GO:0019842 vitamin binding 13/1652 150/18639 0.0866666666666667 0.977832929782082 0.575940040194462 0.898698842054223 GO:0070279 vitamin B6 binding 5/1652 57/18639 0.087719298245614 0.989709443099274 0.577367224443586 0.898698842054223 GO:0016758 hexosyltransferase activity 17/1652 197/18639 0.0862944162436548 0.973632944531163 0.583000243523617 0.898698842054223 GO:0003823 antigen binding 15/1652 174/18639 0.0862068965517241 0.972645487183769 0.584128565455772 0.898698842054223 GO:0015294 solute:monoatomic cation symporter activity 10/1652 116/18639 0.0862068965517241 0.972645487183769 0.584463445919684 0.898698842054223 GO:0031490 chromatin DNA binding 11/1652 128/18639 0.0859375 0.96960597003632 0.588340011899924 0.898698842054223 GO:0008376 acetylgalactosaminyltransferase activity 3/1652 34/18639 0.0882352941176471 0.995531263352799 0.590534347256865 0.898698842054223 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/1652 46/18639 0.0869565217391304 0.981103274028845 0.591291653770134 0.898698842054223 GO:0015377 chloride:monoatomic cation symporter activity 2/1652 22/18639 0.0909090909090909 1.02569887739379 0.592643094179032 0.898698842054223 GO:0034062 5'-3' RNA polymerase activity 2/1652 22/18639 0.0909090909090909 1.02569887739379 0.592643094179032 0.898698842054223 GO:0050321 tau-protein kinase activity 2/1652 22/18639 0.0909090909090909 1.02569887739379 0.592643094179032 0.898698842054223 GO:0097747 RNA polymerase activity 2/1652 22/18639 0.0909090909090909 1.02569887739379 0.592643094179032 0.898698842054223 GO:0140517 protein-RNA adaptor activity 2/1652 22/18639 0.0909090909090909 1.02569887739379 0.592643094179032 0.898698842054223 GO:0140784 metal ion sensor activity 2/1652 22/18639 0.0909090909090909 1.02569887739379 0.592643094179032 0.898698842054223 GO:0061980 regulatory RNA binding 5/1652 58/18639 0.0862068965517241 0.972645487183769 0.59317928681542 0.898698842054223 GO:0016410 N-acyltransferase activity 8/1652 94/18639 0.0851063829787234 0.960228736283551 0.600982173499227 0.898698842054223 GO:0000182 rDNA binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0004090 carbonyl reductase (NADPH) activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0004382 GDP phosphatase activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0004955 prostaglandin receptor activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0005031 tumor necrosis factor receptor activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0005131 growth hormone receptor binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0005381 iron ion transmembrane transporter activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0005522 profilin binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0005528 FK506 binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0008140 cAMP response element binding protein binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0008401 retinoic acid 4-hydroxylase activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0008519 ammonium channel activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0015187 glycine transmembrane transporter activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0015279 store-operated calcium channel activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0031434 mitogen-activated protein kinase kinase binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0032356 oxidized DNA binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0033204 ribonuclease P RNA binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0035256 G protein-coupled glutamate receptor binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0042975 peroxisome proliferator activated receptor binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0043295 glutathione binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0045322 unmethylated CpG binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0050308 sugar-phosphatase activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0050815 phosphoserine residue binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0070097 delta-catenin binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0070513 death domain binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0098505 G-rich strand telomeric DNA binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0099122 RNA polymerase II C-terminal domain binding 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0140940 histone H2A methyltransferase activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0141109 transporter activator activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:1990259 histone H2AQ104 methyltransferase activity 1/1652 10/18639 0.1 1.12826876513317 0.604780122398785 0.898698842054223 GO:0004623 phospholipase A2 activity 3/1652 35/18639 0.0857142857142857 0.96708751297129 0.610594310390179 0.901614162549012 GO:0005343 organic acid:sodium symporter activity 3/1652 35/18639 0.0857142857142857 0.96708751297129 0.610594310390179 0.901614162549012 GO:0016229 steroid dehydrogenase activity 3/1652 35/18639 0.0857142857142857 0.96708751297129 0.610594310390179 0.901614162549012 GO:0008135 translation factor activity, RNA binding 7/1652 83/18639 0.0843373493975904 0.951551970594241 0.611257380590863 0.901614162549012 GO:0005212 structural constituent of eye lens 2/1652 23/18639 0.0869565217391304 0.981103274028845 0.617271511217721 0.901614162549012 GO:0043274 phospholipase binding 2/1652 23/18639 0.0869565217391304 0.981103274028845 0.617271511217721 0.901614162549012 GO:0180051 translation factor activity 7/1652 84/18639 0.0833333333333333 0.94022397094431 0.624060365406825 0.901614162549012 GO:0032182 ubiquitin-like protein binding 10/1652 120/18639 0.0833333333333333 0.94022397094431 0.628122657098333 0.901614162549012 GO:0004033 aldo-keto reductase (NADPH) activity 3/1652 36/18639 0.0833333333333333 0.94022397094431 0.629984216149101 0.901614162549012 GO:0055106 ubiquitin-protein transferase regulator activity 3/1652 36/18639 0.0833333333333333 0.94022397094431 0.629984216149101 0.901614162549012 GO:0016836 hydro-lyase activity 5/1652 61/18639 0.0819672131147541 0.924810463223911 0.638564456504454 0.901614162549012 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0001851 complement component C3b binding 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0004954 prostanoid receptor activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0008046 axon guidance receptor activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0008172 S-methyltransferase activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0008503 benzodiazepine receptor activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0019107 myristoyltransferase activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0019203 carbohydrate phosphatase activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0019215 intermediate filament binding 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0032794 GTPase activating protein binding 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0045294 alpha-catenin binding 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0047676 arachidonate-CoA ligase activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0048407 platelet-derived growth factor binding 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0050998 nitric-oxide synthase binding 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0180030 inositol phosphate kinase activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:1900750 oligopeptide binding 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:1990948 ubiquitin ligase inhibitor activity 1/1652 11/18639 0.0909090909090909 1.02569887739379 0.639827802778687 0.901614162549012 GO:0015149 hexose transmembrane transporter activity 2/1652 24/18639 0.0833333333333333 0.94022397094431 0.64073727781147 0.901614162549012 GO:0015295 solute:proton symporter activity 2/1652 24/18639 0.0833333333333333 0.94022397094431 0.64073727781147 0.901614162549012 GO:0019957 C-C chemokine binding 2/1652 24/18639 0.0833333333333333 0.94022397094431 0.64073727781147 0.901614162549012 GO:0030552 cAMP binding 2/1652 24/18639 0.0833333333333333 0.94022397094431 0.64073727781147 0.901614162549012 GO:0050699 WW domain binding 2/1652 24/18639 0.0833333333333333 0.94022397094431 0.64073727781147 0.901614162549012 GO:0055056 D-glucose transmembrane transporter activity 2/1652 24/18639 0.0833333333333333 0.94022397094431 0.64073727781147 0.901614162549012 GO:0016209 antioxidant activity 7/1652 86/18639 0.0813953488372093 0.918358297201419 0.648946966848101 0.902597392086365 GO:0003678 DNA helicase activity 6/1652 74/18639 0.0810810810810811 0.914812512270139 0.650298726115141 0.902597392086365 GO:0003684 damaged DNA binding 6/1652 74/18639 0.0810810810810811 0.914812512270139 0.650298726115141 0.902597392086365 GO:0031491 nucleosome binding 6/1652 74/18639 0.0810810810810811 0.914812512270139 0.650298726115141 0.902597392086365 GO:0035064 methylated histone binding 6/1652 74/18639 0.0810810810810811 0.914812512270139 0.650298726115141 0.902597392086365 GO:0015293 symporter activity 12/1652 146/18639 0.0821917808219178 0.927344190520415 0.650811655257898 0.902597392086365 GO:0008081 phosphoric diester hydrolase activity 7/1652 87/18639 0.0804597701149425 0.907802454704851 0.661017802247968 0.902597392086365 GO:0001848 complement binding 2/1652 25/18639 0.08 0.902615012106538 0.663052898749029 0.902597392086365 GO:0005251 delayed rectifier potassium channel activity 2/1652 25/18639 0.08 0.902615012106538 0.663052898749029 0.902597392086365 GO:0008483 transaminase activity 2/1652 25/18639 0.08 0.902615012106538 0.663052898749029 0.902597392086365 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/1652 25/18639 0.08 0.902615012106538 0.663052898749029 0.902597392086365 GO:0047617 fatty acyl-CoA hydrolase activity 2/1652 25/18639 0.08 0.902615012106538 0.663052898749029 0.902597392086365 GO:0001217 DNA-binding transcription repressor activity 23/1652 278/18639 0.0827338129496403 0.933459769714495 0.667129104711297 0.902597392086365 GO:0019838 growth factor binding 11/1652 136/18639 0.0808823529411765 0.912570324740065 0.669144652259773 0.902597392086365 GO:0043130 ubiquitin binding 8/1652 100/18639 0.08 0.902615012106538 0.670921364626222 0.902597392086365 GO:0003995 acyl-CoA dehydrogenase activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0004526 ribonuclease P activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0004859 phospholipase inhibitor activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0005078 MAP-kinase scaffold activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0005247 voltage-gated chloride channel activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0005436 sodium:phosphate symporter activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0005527 macrolide binding 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0008179 adenylate cyclase binding 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0010853 cyclase activator activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0016208 AMP binding 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0016423 tRNA (guanine) methyltransferase activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0016801 hydrolase activity, acting on ether bonds 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0016803 ether hydrolase activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0017166 vinculin binding 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0031543 peptidyl-proline dioxygenase activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0035251 UDP-glucosyltransferase activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0036009 protein-glutamine N-methyltransferase activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0042301 phosphate ion binding 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0043047 single-stranded telomeric DNA binding 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0070410 co-SMAD binding 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0097371 MDM2/MDM4 family protein binding 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/1652 12/18639 0.0833333333333333 0.94022397094431 0.671769206569196 0.902597392086365 GO:0003743 translation initiation factor activity 4/1652 51/18639 0.0784313725490196 0.884916678535821 0.673285890097712 0.902647017493636 GO:0016830 carbon-carbon lyase activity 4/1652 51/18639 0.0784313725490196 0.884916678535821 0.673285890097712 0.902647017493636 GO:0140034 methylation-dependent protein binding 6/1652 76/18639 0.0789473684210526 0.890738498789346 0.675890307386769 0.905143990133763 GO:0004866 endopeptidase inhibitor activity 13/1652 161/18639 0.0807453416149068 0.91102446874107 0.678514191942132 0.907661528694519 GO:0004536 DNA nuclease activity 5/1652 64/18639 0.078125 0.881459972760291 0.680674807656151 0.908346144989847 GO:0004435 phosphatidylinositol phospholipase C activity 2/1652 26/18639 0.0769230769230769 0.86789905010244 0.684237792824319 0.908346144989847 GO:0005227 calcium-activated cation channel activity 2/1652 26/18639 0.0769230769230769 0.86789905010244 0.684237792824319 0.908346144989847 GO:0015145 monosaccharide transmembrane transporter activity 2/1652 26/18639 0.0769230769230769 0.86789905010244 0.684237792824319 0.908346144989847 GO:0016289 acyl-CoA hydrolase activity 2/1652 26/18639 0.0769230769230769 0.86789905010244 0.684237792824319 0.908346144989847 GO:0030507 spectrin binding 2/1652 26/18639 0.0769230769230769 0.86789905010244 0.684237792824319 0.908346144989847 GO:0050681 nuclear androgen receptor binding 2/1652 26/18639 0.0769230769230769 0.86789905010244 0.684237792824319 0.908346144989847 GO:0004177 aminopeptidase activity 3/1652 40/18639 0.075 0.846201573849879 0.70072017295942 0.912564545564461 GO:0015036 disulfide oxidoreductase activity 3/1652 40/18639 0.075 0.846201573849879 0.70072017295942 0.912564545564461 GO:0015144 carbohydrate transmembrane transporter activity 3/1652 40/18639 0.075 0.846201573849879 0.70072017295942 0.912564545564461 GO:0005035 death receptor activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0009982 pseudouridine synthase activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0019104 DNA N-glycosylase activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0032396 inhibitory MHC class I receptor activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0043560 insulin receptor substrate binding 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0045159 myosin II binding 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0046974 histone H3K9 methyltransferase activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0070700 BMP receptor binding 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0071714 icosanoid transmembrane transporter activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0089720 caspase binding 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0140666 annealing activity 1/1652 13/18639 0.0769230769230769 0.86789905010244 0.700879491142541 0.912564545564461 GO:0016860 intramolecular oxidoreductase activity 4/1652 53/18639 0.0754716981132075 0.851523596326922 0.702700600089109 0.913960268772615 GO:0008320 protein transmembrane transporter activity 2/1652 27/18639 0.0740740740740741 0.835754640839387 0.704316970416706 0.91411351479615 GO:0016405 CoA-ligase activity 2/1652 27/18639 0.0740740740740741 0.835754640839387 0.704316970416706 0.91411351479615 GO:0008235 metalloexopeptidase activity 5/1652 66/18639 0.0757575757575758 0.854749064494827 0.706850763575454 0.916427132372002 GO:0015370 solute:sodium symporter activity 6/1652 79/18639 0.0759493670886076 0.856912986177093 0.711948911275018 0.921079185318687 GO:0033293 monocarboxylic acid binding 6/1652 79/18639 0.0759493670886076 0.856912986177093 0.711948911275018 0.921079185318687 GO:0003774 cytoskeletal motor activity 12/1652 153/18639 0.0784313725490196 0.884916678535821 0.71314697305692 0.921651808399833 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/1652 54/18639 0.0740740740740741 0.835754640839387 0.716670679391256 0.924285626477806 GO:0140318 protein transporter activity 3/1652 41/18639 0.0731707317073171 0.825562511073053 0.716700166104922 0.924285626477806 GO:0005506 iron ion binding 12/1652 154/18639 0.0779220779220779 0.879170466337537 0.72145407079836 0.924416180609836 GO:0046966 nuclear thyroid hormone receptor binding 2/1652 28/18639 0.0714285714285714 0.805906260809409 0.723319890945017 0.924416180609836 GO:0051119 sugar transmembrane transporter activity 2/1652 28/18639 0.0714285714285714 0.805906260809409 0.723319890945017 0.924416180609836 GO:0004705 JUN kinase activity 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0005344 oxygen carrier activity 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0008191 metalloendopeptidase inhibitor activity 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0008195 phosphatidate phosphatase activity 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0008559 ABC-type xenobiotic transporter activity 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0042813 Wnt receptor activity 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0043176 amine binding 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0071933 Arp2/3 complex binding 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0098847 sequence-specific single stranded DNA binding 1/1652 14/18639 0.0714285714285714 0.805906260809409 0.727409453594625 0.924416180609836 GO:0008307 structural constituent of muscle 3/1652 42/18639 0.0714285714285714 0.805906260809409 0.732010112662102 0.927364836394356 GO:0031492 nucleosomal DNA binding 3/1652 42/18639 0.0714285714285714 0.805906260809409 0.732010112662102 0.927364836394356 GO:0035198 miRNA binding 3/1652 42/18639 0.0714285714285714 0.805906260809409 0.732010112662102 0.927364836394356 GO:0015101 organic cation transmembrane transporter activity 6/1652 81/18639 0.0740740740740741 0.835754640839387 0.734405574272091 0.929434440468829 GO:0003785 actin monomer binding 2/1652 29/18639 0.0689655172413793 0.778116389747015 0.741279478728146 0.930900484456164 GO:0004181 metallocarboxypeptidase activity 2/1652 29/18639 0.0689655172413793 0.778116389747015 0.741279478728146 0.930900484456164 GO:0004629 phospholipase C activity 2/1652 29/18639 0.0689655172413793 0.778116389747015 0.741279478728146 0.930900484456164 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 10/1652 132/18639 0.0757575757575758 0.854749064494827 0.743041151706241 0.930900484456164 GO:0019212 phosphatase inhibitor activity 4/1652 56/18639 0.0714285714285714 0.805906260809409 0.743144417198777 0.930900484456164 GO:0030414 peptidase inhibitor activity 13/1652 169/18639 0.0769230769230769 0.86789905010244 0.743288350952582 0.930900484456164 GO:0004867 serine-type endopeptidase inhibitor activity 7/1652 95/18639 0.0736842105263158 0.83135593220339 0.748110672801856 0.930900484456164 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0005523 tropomyosin binding 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0008242 omega peptidase activity 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0045504 dynein heavy chain binding 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0048531 beta-1,3-galactosyltransferase activity 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0050780 dopamine receptor binding 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0061578 K63-linked deubiquitinase activity 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0141050 histone H3K deacetylase activity 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0141051 histone H4K deacetylase activity 1/1652 15/18639 0.0666666666666667 0.752179176755448 0.751587686220756 0.930900484456164 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 21/1652 268/18639 0.0783582089552239 0.884091196559575 0.754778303162075 0.933904188496686 GO:0015932 nucleobase-containing compound transmembrane transporter activity 4/1652 57/18639 0.0701754385964912 0.791767554479419 0.755655903444451 0.934042758056971 GO:0016769 transferase activity, transferring nitrogenous groups 2/1652 30/18639 0.0666666666666667 0.752179176755448 0.758231278174016 0.93438601956798 GO:0022839 monoatomic ion-gated channel activity 2/1652 30/18639 0.0666666666666667 0.752179176755448 0.758231278174016 0.93438601956798 GO:0098918 structural constituent of synapse 2/1652 30/18639 0.0666666666666667 0.752179176755448 0.758231278174016 0.93438601956798 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/1652 44/18639 0.0681818181818182 0.769274158045344 0.760662348379922 0.93552258563295 GO:0004620 phospholipase activity 8/1652 109/18639 0.073394495412844 0.828087167070218 0.760687217170398 0.93552258563295 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 9/1652 122/18639 0.0737704918032787 0.83232941690152 0.764024045914627 0.938680096692694 GO:0140299 molecular sensor activity 5/1652 71/18639 0.0704225352112676 0.794555468403642 0.765561631756636 0.939622928312974 GO:0000062 fatty-acyl-CoA binding 1/1652 16/18639 0.0625 0.705167978208232 0.773622541373425 0.941935629217144 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1652 16/18639 0.0625 0.705167978208232 0.773622541373425 0.941935629217144 GO:0004707 MAP kinase activity 1/1652 16/18639 0.0625 0.705167978208232 0.773622541373425 0.941935629217144 GO:0008142 oxysterol binding 1/1652 16/18639 0.0625 0.705167978208232 0.773622541373425 0.941935629217144 GO:0015562 efflux transmembrane transporter activity 1/1652 16/18639 0.0625 0.705167978208232 0.773622541373425 0.941935629217144 GO:0022858 alanine transmembrane transporter activity 1/1652 16/18639 0.0625 0.705167978208232 0.773622541373425 0.941935629217144 GO:0030275 LRR domain binding 1/1652 16/18639 0.0625 0.705167978208232 0.773622541373425 0.941935629217144 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1652 16/18639 0.0625 0.705167978208232 0.773622541373425 0.941935629217144 GO:0005249 voltage-gated potassium channel activity 7/1652 98/18639 0.0714285714285714 0.805906260809409 0.776320114939266 0.94427770710459 GO:0004175 endopeptidase activity 32/1652 405/18639 0.0790123456790123 0.891471616895346 0.778724410217838 0.945623813975569 GO:0005200 structural constituent of cytoskeleton 8/1652 112/18639 0.0714285714285714 0.805906260809409 0.786370051728425 0.945623813975569 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/1652 46/18639 0.0652173913043478 0.735827455521634 0.786779704432447 0.945623813975569 GO:0008378 galactosyltransferase activity 2/1652 32/18639 0.0625 0.705167978208232 0.789262562918975 0.945623813975569 GO:0051059 NF-kappaB binding 2/1652 32/18639 0.0625 0.705167978208232 0.789262562918975 0.945623813975569 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/1652 60/18639 0.0666666666666667 0.752179176755448 0.79036219320708 0.945623813975569 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 4/1652 60/18639 0.0666666666666667 0.752179176755448 0.79036219320708 0.945623813975569 GO:0004252 serine-type endopeptidase activity 13/1652 176/18639 0.0738636363636364 0.833380337882457 0.792407364145308 0.945623813975569 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0009881 photoreceptor activity 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0015278 intracellularly gated calcium channel activity 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0030548 acetylcholine receptor regulator activity 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0031489 myosin V binding 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0032977 membrane insertase activity 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0036041 long-chain fatty acid binding 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0045236 CXCR chemokine receptor binding 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0048038 quinone binding 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0070402 NADPH binding 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0070492 oligosaccharide binding 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:1901567 fatty acid derivative binding 1/1652 17/18639 0.0588235294117647 0.663687508901866 0.793703922549986 0.945623813975569 GO:0022804 active transmembrane transporter activity 36/1652 457/18639 0.0787746170678337 0.888789399229632 0.796036052017807 0.947477057035829 GO:0043495 protein-membrane adaptor activity 3/1652 47/18639 0.0638297872340425 0.720171552212663 0.798926319472401 0.949990360386286 GO:0046906 tetrapyrrole binding 11/1652 152/18639 0.0723684210526316 0.816510290556901 0.799999128631008 0.950339763320185 GO:0030296 protein tyrosine kinase activator activity 2/1652 33/18639 0.0606060606060606 0.683799251595862 0.803420259040281 0.950715929774587 GO:0019003 GDP binding 5/1652 75/18639 0.0666666666666667 0.752179176755448 0.805753576293961 0.950715929774587 GO:0003746 translation elongation factor activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0008308 voltage-gated monoatomic anion channel activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0008409 5'-3' exonuclease activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0008525 phosphatidylcholine transporter activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0016854 racemase and epimerase activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0017128 phospholipid scramblase activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0022851 GABA-gated chloride ion channel activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0070064 proline-rich region binding 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0099602 neurotransmitter receptor regulator activity 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:1990381 ubiquitin-specific protease binding 1/1652 18/18639 0.0555555555555556 0.62681598062954 0.812004917069771 0.950715929774587 GO:0016874 ligase activity 12/1652 167/18639 0.0718562874251497 0.810732046802279 0.815171168956231 0.952586297134444 GO:0015020 glucuronosyltransferase activity 2/1652 34/18639 0.0588235294117647 0.663687508901866 0.816725628526745 0.952586297134444 GO:0015035 protein-disulfide reductase activity 2/1652 34/18639 0.0588235294117647 0.663687508901866 0.816725628526745 0.952586297134444 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/1652 34/18639 0.0588235294117647 0.663687508901866 0.816725628526745 0.952586297134444 GO:0005253 monoatomic anion channel activity 7/1652 103/18639 0.0679611650485437 0.766784597663321 0.818022961215187 0.953188168751221 GO:1901682 sulfur compound transmembrane transporter activity 4/1652 63/18639 0.0634920634920635 0.716361120719474 0.821001303635118 0.955745792399661 GO:0016298 lipase activity 9/1652 130/18639 0.0692307692307692 0.781109145092196 0.824406598498848 0.956474557141768 GO:0003756 protein disulfide isomerase activity 1/1652 19/18639 0.0526315789473684 0.593825665859564 0.828683284343319 0.956474557141768 GO:0004890 GABA-A receptor activity 1/1652 19/18639 0.0526315789473684 0.593825665859564 0.828683284343319 0.956474557141768 GO:0008301 DNA binding, bending 1/1652 19/18639 0.0526315789473684 0.593825665859564 0.828683284343319 0.956474557141768 GO:0008574 plus-end-directed microtubule motor activity 1/1652 19/18639 0.0526315789473684 0.593825665859564 0.828683284343319 0.956474557141768 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/1652 19/18639 0.0526315789473684 0.593825665859564 0.828683284343319 0.956474557141768 GO:0030506 ankyrin binding 1/1652 19/18639 0.0526315789473684 0.593825665859564 0.828683284343319 0.956474557141768 GO:0046624 sphingolipid transporter activity 1/1652 19/18639 0.0526315789473684 0.593825665859564 0.828683284343319 0.956474557141768 GO:0120227 acyl-CoA binding 1/1652 19/18639 0.0526315789473684 0.593825665859564 0.828683284343319 0.956474557141768 GO:0015605 organophosphate ester transmembrane transporter activity 3/1652 50/18639 0.06 0.676961259079903 0.83192641829621 0.959310236598654 GO:0052689 carboxylic ester hydrolase activity 6/1652 92/18639 0.0652173913043478 0.735827455521634 0.835629340118812 0.962670250184089 GO:0008194 UDP-glycosyltransferase activity 10/1652 145/18639 0.0689655172413793 0.778116389747015 0.837412090290686 0.963084220064711 GO:0019843 rRNA binding 4/1652 65/18639 0.0615384615384615 0.694319240081952 0.839300772876917 0.963084220064711 GO:0160215 deacylase activity 4/1652 65/18639 0.0615384615384615 0.694319240081952 0.839300772876917 0.963084220064711 GO:0016835 carbon-oxygen lyase activity 5/1652 79/18639 0.0632911392405063 0.714094155147577 0.840273126870113 0.963084220064711 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1652 36/18639 0.0555555555555556 0.62681598062954 0.840938095659327 0.963084220064711 GO:0005326 neurotransmitter transmembrane transporter activity 1/1652 20/18639 0.05 0.564134382566586 0.843882812499325 0.963084220064711 GO:0031418 L-ascorbic acid binding 1/1652 20/18639 0.05 0.564134382566586 0.843882812499325 0.963084220064711 GO:0043024 ribosomal small subunit binding 1/1652 20/18639 0.05 0.564134382566586 0.843882812499325 0.963084220064711 GO:0061608 nuclear import signal receptor activity 1/1652 20/18639 0.05 0.564134382566586 0.843882812499325 0.963084220064711 GO:0140664 ATP-dependent DNA damage sensor activity 1/1652 20/18639 0.05 0.564134382566586 0.843882812499325 0.963084220064711 GO:0000049 tRNA binding 5/1652 80/18639 0.0625 0.705167978208232 0.848068915154452 0.964152728390289 GO:0005080 protein kinase C binding 3/1652 52/18639 0.0576923076923077 0.65092428757683 0.851245683964811 0.964152728390289 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/1652 52/18639 0.0576923076923077 0.65092428757683 0.851245683964811 0.964152728390289 GO:0019213 deacetylase activity 2/1652 37/18639 0.0540540540540541 0.609875008180093 0.851923424045184 0.964152728390289 GO:0030280 structural constituent of skin epidermis 2/1652 37/18639 0.0540540540540541 0.609875008180093 0.851923424045184 0.964152728390289 GO:0030551 cyclic nucleotide binding 2/1652 37/18639 0.0540540540540541 0.609875008180093 0.851923424045184 0.964152728390289 GO:0016829 lyase activity 14/1652 200/18639 0.07 0.78978813559322 0.856193659613975 0.964152728390289 GO:0001846 opsonin binding 1/1652 21/18639 0.0476190476190476 0.537270840539606 0.857734555007038 0.964152728390289 GO:0005123 death receptor binding 1/1652 21/18639 0.0476190476190476 0.537270840539606 0.857734555007038 0.964152728390289 GO:0005248 voltage-gated sodium channel activity 1/1652 21/18639 0.0476190476190476 0.537270840539606 0.857734555007038 0.964152728390289 GO:0008373 sialyltransferase activity 1/1652 21/18639 0.0476190476190476 0.537270840539606 0.857734555007038 0.964152728390289 GO:0009975 cyclase activity 1/1652 21/18639 0.0476190476190476 0.537270840539606 0.857734555007038 0.964152728390289 GO:0015125 bile acid transmembrane transporter activity 1/1652 21/18639 0.0476190476190476 0.537270840539606 0.857734555007038 0.964152728390289 GO:0036122 BMP binding 1/1652 21/18639 0.0476190476190476 0.537270840539606 0.857734555007038 0.964152728390289 GO:0051428 peptide hormone receptor binding 1/1652 21/18639 0.0476190476190476 0.537270840539606 0.857734555007038 0.964152728390289 GO:1904047 S-adenosyl-L-methionine binding 1/1652 21/18639 0.0476190476190476 0.537270840539606 0.857734555007038 0.964152728390289 GO:0004864 protein phosphatase inhibitor activity 3/1652 53/18639 0.0566037735849057 0.638642697245192 0.860158388997353 0.964152728390289 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1652 53/18639 0.0566037735849057 0.638642697245192 0.860158388997353 0.964152728390289 GO:0008509 monoatomic anion transmembrane transporter activity 10/1652 149/18639 0.0671140939597315 0.75722735914978 0.860315704224367 0.964152728390289 GO:0000146 microfilament motor activity 2/1652 38/18639 0.0526315789473684 0.593825665859564 0.862212433607315 0.964152728390289 GO:0005501 retinoid binding 2/1652 38/18639 0.0526315789473684 0.593825665859564 0.862212433607315 0.964152728390289 GO:0019840 isoprenoid binding 2/1652 38/18639 0.0526315789473684 0.593825665859564 0.862212433607315 0.964152728390289 GO:0003777 microtubule motor activity 4/1652 68/18639 0.0588235294117647 0.663687508901866 0.863786009943103 0.964152728390289 GO:0005548 phospholipid transporter activity 4/1652 68/18639 0.0588235294117647 0.663687508901866 0.863786009943103 0.964152728390289 GO:0003925 G protein activity 3/1652 54/18639 0.0555555555555556 0.62681598062954 0.868598842503594 0.965306098765822 GO:0017069 snRNA binding 3/1652 54/18639 0.0555555555555556 0.62681598062954 0.868598842503594 0.965306098765822 GO:0005267 potassium channel activity 8/1652 124/18639 0.0645161290322581 0.727915332343982 0.868822462664441 0.965306098765822 GO:0004407 histone deacetylase activity 1/1652 22/18639 0.0454545454545455 0.512849438696896 0.87035795790361 0.965306098765822 GO:0005243 gap junction channel activity 1/1652 22/18639 0.0454545454545455 0.512849438696896 0.87035795790361 0.965306098765822 GO:0031683 G-protein beta/gamma-subunit complex binding 1/1652 22/18639 0.0454545454545455 0.512849438696896 0.87035795790361 0.965306098765822 GO:0033558 protein lysine deacetylase activity 1/1652 22/18639 0.0454545454545455 0.512849438696896 0.87035795790361 0.965306098765822 GO:0042626 ATPase-coupled transmembrane transporter activity 6/1652 98/18639 0.0612244897959184 0.690776794979493 0.876188927663466 0.970890546548073 GO:0140101 catalytic activity, acting on a tRNA 9/1652 139/18639 0.0647482014388489 0.730533732820039 0.877314148370356 0.971255227778434 GO:0071949 FAD binding 2/1652 40/18639 0.05 0.564134382566586 0.880848592664377 0.971880309398443 GO:0016493 C-C chemokine receptor activity 1/1652 23/18639 0.0434782608695652 0.490551637014423 0.881861887298423 0.971880309398443 GO:0016849 phosphorus-oxygen lyase activity 1/1652 23/18639 0.0434782608695652 0.490551637014423 0.881861887298423 0.971880309398443 GO:0016917 GABA receptor activity 1/1652 23/18639 0.0434782608695652 0.490551637014423 0.881861887298423 0.971880309398443 GO:0099186 structural constituent of postsynapse 1/1652 23/18639 0.0434782608695652 0.490551637014423 0.881861887298423 0.971880309398443 GO:0050660 flavin adenine dinucleotide binding 5/1652 86/18639 0.0581395348837209 0.655970212286728 0.888461427366755 0.977254569556156 GO:0020037 heme binding 9/1652 142/18639 0.0633802816901408 0.715099921563278 0.891756597755723 0.977254569556156 GO:0005315 phosphate transmembrane transporter activity 1/1652 24/18639 0.0416666666666667 0.470111985472155 0.892345565971769 0.977254569556156 GO:0005540 hyaluronic acid binding 1/1652 24/18639 0.0416666666666667 0.470111985472155 0.892345565971769 0.977254569556156 GO:0050431 transforming growth factor beta binding 1/1652 24/18639 0.0416666666666667 0.470111985472155 0.892345565971769 0.977254569556156 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/1652 24/18639 0.0416666666666667 0.470111985472155 0.892345565971769 0.977254569556156 GO:0140612 DNA damage sensor activity 1/1652 24/18639 0.0416666666666667 0.470111985472155 0.892345565971769 0.977254569556156 GO:0015171 amino acid transmembrane transporter activity 6/1652 102/18639 0.0588235294117647 0.663687508901866 0.898280044649243 0.98242616166909 GO:0000030 mannosyltransferase activity 1/1652 25/18639 0.04 0.451307506053269 0.90189942710605 0.98242616166909 GO:0005537 D-mannose binding 1/1652 25/18639 0.04 0.451307506053269 0.90189942710605 0.98242616166909 GO:0015271 outward rectifier potassium channel activity 1/1652 25/18639 0.04 0.451307506053269 0.90189942710605 0.98242616166909 GO:0015645 fatty acid ligase activity 1/1652 25/18639 0.04 0.451307506053269 0.90189942710605 0.98242616166909 GO:0120515 fatty acid-CoA ligase activity 1/1652 25/18639 0.04 0.451307506053269 0.90189942710605 0.98242616166909 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1652 43/18639 0.0465116279069767 0.524776169829382 0.904469235881106 0.984346536819758 GO:0015079 potassium ion transmembrane transporter activity 10/1652 160/18639 0.0625 0.705167978208232 0.910227176592225 0.984875167395682 GO:0001637 G protein-coupled chemoattractant receptor activity 1/1652 26/18639 0.0384615384615385 0.43394952505122 0.910605892477319 0.984875167395682 GO:0004950 chemokine receptor activity 1/1652 26/18639 0.0384615384615385 0.43394952505122 0.910605892477319 0.984875167395682 GO:0005112 Notch binding 1/1652 26/18639 0.0384615384615385 0.43394952505122 0.910605892477319 0.984875167395682 GO:0051139 metal cation:proton antiporter activity 1/1652 26/18639 0.0384615384615385 0.43394952505122 0.910605892477319 0.984875167395682 GO:0070006 metalloaminopeptidase activity 1/1652 26/18639 0.0384615384615385 0.43394952505122 0.910605892477319 0.984875167395682 GO:0097602 cullin family protein binding 1/1652 26/18639 0.0384615384615385 0.43394952505122 0.910605892477319 0.984875167395682 GO:0008083 growth factor activity 10/1652 162/18639 0.0617283950617284 0.696462200699489 0.917465000106342 0.989946024541129 GO:0046915 transition metal ion transmembrane transporter activity 2/1652 45/18639 0.0444444444444444 0.501452784503632 0.917702610773246 0.989946024541129 GO:0008395 steroid hydroxylase activity 1/1652 27/18639 0.037037037037037 0.417877320419693 0.918540081787343 0.989946024541129 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/1652 27/18639 0.037037037037037 0.417877320419693 0.918540081787343 0.989946024541129 GO:0015108 chloride transmembrane transporter activity 7/1652 121/18639 0.0578512396694215 0.652717467432414 0.919884148979371 0.990519560242571 GO:0005242 inward rectifier potassium channel activity 1/1652 28/18639 0.0357142857142857 0.402953130404704 0.925770459225947 0.992477996709715 GO:0008527 taste receptor activity 1/1652 28/18639 0.0357142857142857 0.402953130404704 0.925770459225947 0.992477996709715 GO:0016866 intramolecular transferase activity 1/1652 28/18639 0.0357142857142857 0.402953130404704 0.925770459225947 0.992477996709715 GO:0051537 2 iron, 2 sulfur cluster binding 1/1652 28/18639 0.0357142857142857 0.402953130404704 0.925770459225947 0.992477996709715 GO:0051959 dynein light intermediate chain binding 1/1652 28/18639 0.0357142857142857 0.402953130404704 0.925770459225947 0.992477996709715 GO:0015103 inorganic anion transmembrane transporter activity 10/1652 165/18639 0.0606060606060606 0.683799251595862 0.927389424493501 0.992809816114168 GO:0042562 hormone binding 5/1652 94/18639 0.0531914893617021 0.600142960177219 0.927707533090288 0.992809816114168 GO:0140359 ABC-type transporter activity 2/1652 47/18639 0.0425531914893617 0.480114368141775 0.929197088970473 0.993532382597701 GO:0015291 secondary active transmembrane transporter activity 19/1652 287/18639 0.0662020905923345 0.746937510018476 0.931756482775117 0.993824947108315 GO:0035250 UDP-galactosyltransferase activity 1/1652 29/18639 0.0344827586206897 0.389058194873508 0.932359422815154 0.993824947108315 GO:0099604 ligand-gated calcium channel activity 1/1652 29/18639 0.0344827586206897 0.389058194873508 0.932359422815154 0.993824947108315 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 11/1652 181/18639 0.0607734806629834 0.68568819980469 0.934047341519633 0.993824947108315 GO:1901681 sulfur compound binding 18/1652 275/18639 0.0654545454545455 0.738503191723531 0.934351110523771 0.993824947108315 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/1652 48/18639 0.0416666666666667 0.470111985472155 0.934358372404293 0.993824947108315 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/1652 30/18639 0.0333333333333333 0.376089588377724 0.938363841595883 0.994616756513447 GO:0015215 nucleotide transmembrane transporter activity 1/1652 30/18639 0.0333333333333333 0.376089588377724 0.938363841595883 0.994616756513447 GO:0033612 receptor serine/threonine kinase binding 1/1652 30/18639 0.0333333333333333 0.376089588377724 0.938363841595883 0.994616756513447 GO:0051721 protein phosphatase 2A binding 1/1652 30/18639 0.0333333333333333 0.376089588377724 0.938363841595883 0.994616756513447 GO:0005254 chloride channel activity 4/1652 83/18639 0.0481927710843374 0.543743983196709 0.943606505786076 0.996089416289087 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1652 31/18639 0.032258064516129 0.363957666171991 0.943835545270643 0.996089416289087 GO:0005452 solute:inorganic anion antiporter activity 1/1652 31/18639 0.032258064516129 0.363957666171991 0.943835545270643 0.996089416289087 GO:0017147 Wnt-protein binding 1/1652 31/18639 0.032258064516129 0.363957666171991 0.943835545270643 0.996089416289087 GO:0072349 modified amino acid transmembrane transporter activity 1/1652 31/18639 0.032258064516129 0.363957666171991 0.943835545270643 0.996089416289087 GO:0022843 voltage-gated monoatomic cation channel activity 8/1652 143/18639 0.0559440559440559 0.631199309165411 0.944992552941417 0.996181204836065 GO:0140223 general transcription initiation factor activity 3/1652 68/18639 0.0441176470588235 0.497765631676399 0.947338947785377 0.996181204836065 GO:0005272 sodium channel activity 2/1652 51/18639 0.0392156862745098 0.442458339267911 0.947784406831862 0.996181204836065 GO:0015106 bicarbonate transmembrane transporter activity 1/1652 32/18639 0.03125 0.352583989104116 0.948821770507793 0.996181204836065 GO:0030515 snoRNA binding 1/1652 32/18639 0.03125 0.352583989104116 0.948821770507793 0.996181204836065 GO:0042910 xenobiotic transmembrane transporter activity 1/1652 32/18639 0.03125 0.352583989104116 0.948821770507793 0.996181204836065 GO:0042923 neuropeptide binding 1/1652 33/18639 0.0303030303030303 0.341899625797931 0.953365567741153 0.99842523913754 GO:0016782 transferase activity, transferring sulphur-containing groups 3/1652 70/18639 0.0428571428571429 0.483543756485645 0.954047040318588 0.99842523913754 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1652 53/18639 0.0377358490566038 0.425761798163461 0.955233703462199 0.99842523913754 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1652 34/18639 0.0294117647058824 0.331843754450933 0.957506171959772 0.99842523913754 GO:0016831 carboxy-lyase activity 1/1652 34/18639 0.0294117647058824 0.331843754450933 0.957506171959772 0.99842523913754 GO:0019825 oxygen binding 1/1652 34/18639 0.0294117647058824 0.331843754450933 0.957506171959772 0.99842523913754 GO:0051427 hormone receptor binding 1/1652 34/18639 0.0294117647058824 0.331843754450933 0.957506171959772 0.99842523913754 GO:0090482 vitamin transmembrane transporter activity 1/1652 34/18639 0.0294117647058824 0.331843754450933 0.957506171959772 0.99842523913754 GO:0016853 isomerase activity 10/1652 180/18639 0.0555555555555556 0.62681598062954 0.963025654518701 0.999544148155571 GO:0004497 monooxygenase activity 5/1652 106/18639 0.0471698113207547 0.532202247704326 0.963756844756541 0.999544148155571 GO:0170055 lipid transmembrane transporter activity 2/1652 56/18639 0.0357142857142857 0.402953130404704 0.964530488364445 0.999544148155571 GO:0004190 aspartic-type endopeptidase activity 1/1652 36/18639 0.0277777777777778 0.31340799031477 0.964717661959815 0.999544148155571 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/1652 36/18639 0.0277777777777778 0.31340799031477 0.964717661959815 0.999544148155571 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/1652 36/18639 0.0277777777777778 0.31340799031477 0.964717661959815 0.999544148155571 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/1652 36/18639 0.0277777777777778 0.31340799031477 0.964717661959815 0.999544148155571 GO:0048029 monosaccharide binding 3/1652 74/18639 0.0405405405405405 0.45740625613507 0.965133611907593 0.999544148155571 GO:0042805 actinin binding 1/1652 37/18639 0.027027027027027 0.304937504090046 0.967850835235222 0.999999998343656 GO:0070001 aspartic-type peptidase activity 1/1652 37/18639 0.027027027027027 0.304937504090046 0.967850835235222 0.999999998343656 GO:0004222 metalloendopeptidase activity 5/1652 110/18639 0.0454545454545455 0.512849438696896 0.971476728816789 0.999999998343656 GO:0008201 heparin binding 9/1652 172/18639 0.0523255813953488 0.590373191058055 0.973037628832901 0.999999998343656 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/1652 39/18639 0.0256410256410256 0.28929968336748 0.973307604947216 0.999999998343656 GO:0005244 voltage-gated monoatomic ion channel activity 9/1652 173/18639 0.0520231213872832 0.586960629260032 0.974357430596969 0.999999998343656 GO:0032451 demethylase activity 1/1652 40/18639 0.025 0.282067191283293 0.975678348851904 0.999999998343656 GO:0022832 voltage-gated channel activity 9/1652 175/18639 0.0514285714285714 0.580252507782774 0.976821946823589 0.999999998343656 GO:0140828 metal cation:monoatomic cation antiporter activity 1/1652 41/18639 0.024390243902439 0.275187503691018 0.977838646055875 0.999999998343656 GO:0016859 cis-trans isomerase activity 1/1652 42/18639 0.0238095238095238 0.268635420269803 0.979807167225662 0.999999998343656 GO:0015081 sodium ion transmembrane transporter activity 8/1652 164/18639 0.0487804878048781 0.550375007382035 0.98122599001329 0.999999998343656 GO:0015297 antiporter activity 6/1652 135/18639 0.0444444444444444 0.501452784503632 0.983388304612685 0.999999998343656 GO:0005539 glycosaminoglycan binding 13/1652 242/18639 0.0537190082644628 0.606094791187241 0.984590782355562 0.999999998343656 GO:0008237 metallopeptidase activity 9/1652 184/18639 0.0489130434782609 0.551870591641225 0.985446804105027 0.999999998343656 GO:0099095 ligand-gated monoatomic anion channel activity 1/1652 47/18639 0.0212765957446809 0.240057184070888 0.987318579946596 0.999999998343656 GO:0017046 peptide hormone binding 1/1652 53/18639 0.0188679245283019 0.212880899081731 0.992744664785793 0.999999998343656 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/1652 53/18639 0.0188679245283019 0.212880899081731 0.992744664785793 0.999999998343656 GO:0005179 hormone activity 5/1652 132/18639 0.0378787878787879 0.427374532247414 0.992873938443576 0.999999998343656 GO:0003730 mRNA 3'-UTR binding 13/1652 262/18639 0.049618320610687 0.559828013234017 0.994107786466607 0.999999998343656 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/1652 56/18639 0.0178571428571429 0.201476565202352 0.994512538183791 0.999999998343656 GO:0046943 carboxylic acid transmembrane transporter activity 8/1652 188/18639 0.0425531914893617 0.480114368141775 0.995116953421732 0.999999998343656 GO:0005342 organic acid transmembrane transporter activity 8/1652 189/18639 0.0423280423280423 0.477574080479649 0.995394251951024 0.999999998343656 GO:0005261 monoatomic cation channel activity 18/1652 341/18639 0.0527859237536657 0.595567090099621 0.995433100729705 0.999999998343656 GO:0005216 monoatomic ion channel activity 25/1652 448/18639 0.0558035714285714 0.62961426625735 0.996625229954778 0.999999998343656 GO:0022824 transmitter-gated monoatomic ion channel activity 1/1652 63/18639 0.0158730158730159 0.179090280179869 0.997140493470576 0.999999998343656 GO:0022835 transmitter-gated channel activity 1/1652 63/18639 0.0158730158730159 0.179090280179869 0.997140493470576 0.999999998343656 GO:0005262 calcium channel activity 4/1652 131/18639 0.0305343511450382 0.344509546605549 0.997794579700046 0.999999998343656 GO:0098960 postsynaptic neurotransmitter receptor activity 1/1652 69/18639 0.0144927536231884 0.163517212338141 0.998364834410626 0.999999998343656 GO:0099094 ligand-gated monoatomic cation channel activity 4/1652 136/18639 0.0294117647058824 0.331843754450933 0.998465707162604 0.999999998343656 GO:0008028 monocarboxylic acid transmembrane transporter activity 1/1652 70/18639 0.0142857142857143 0.161181252161882 0.99851029986855 0.999999998343656 GO:0030594 neurotransmitter receptor activity 2/1652 97/18639 0.0206185567010309 0.232632735079005 0.998739955423519 0.999999998343656 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/1652 73/18639 0.0136986301369863 0.154557365086736 0.99887358998565 0.999999998343656 GO:0008514 organic anion transmembrane transporter activity 11/1652 269/18639 0.0408921933085502 0.461373844478249 0.999250398915947 0.999999998343656 GO:0015085 calcium ion transmembrane transporter activity 4/1652 147/18639 0.0272108843537415 0.307011908879775 0.999317799248125 0.999999998343656 GO:0046873 metal ion transmembrane transporter activity 22/1652 450/18639 0.0488888888888889 0.551598062953995 0.99956207525118 0.999999998343656 GO:0015276 ligand-gated monoatomic ion channel activity 5/1652 186/18639 0.0268817204301075 0.303298055143326 0.999834726526077 0.999999998343656 GO:0022834 ligand-gated channel activity 5/1652 188/18639 0.0265957446808511 0.30007148008861 0.999857270868147 0.999999998343656 GO:0022836 gated channel activity 12/1652 318/18639 0.0377358490566038 0.425761798163461 0.999889855314306 0.999999998343656 GO:0008528 G protein-coupled peptide receptor activity 1/1652 122/18639 0.00819672131147541 0.0924810463223911 0.999988362068368 0.999999998343656 GO:0001653 peptide receptor activity 1/1652 128/18639 0.0078125 0.0881459972760291 0.999993357437535 0.999999998343656 GO:0030371 translation repressor activity 5/1652 329/18639 0.0151975683890578 0.171469417193491 0.999999997835554 0.999999998343656 GO:0045182 translation regulator activity 6/1652 356/18639 0.0168539325842697 0.190157657044917 0.999999998343656 0.999999998343656