category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	79/869	222/9376	3.83947583947584	RPS12/RPL35/RPS24/RPL13/RPL36/RPS7/RPS10/RPLP1/RPL36AL/RPS8/RPL39/RPL36A/RPS3A/RPL35A/RPL32/RPS15A/RPL26/RPL19/RPS18/RPS28/RPS15/RPL8/FAU/MRPL33/RPS3/RPL11/RPS19/RPL28/RPL34/RPS14/RPL41/RPLP2/RPL18/RPL38/RPL24/MRPL52/RPL21/RSL24D1/MRPS6/MRPS33/MRPL42/RPL14/MRPS21/RPS27A/RPL17/RPS21/RPL27/MRPL54/MRPL47/MRPL28/MRPL12/MRPL2/MRPL4/MRPL27/MRPS18B/RPL26L1/MRPL22/MRPL43/RPS6/MRPL37/RPL22/UBA52/RPS5/RPL22L1/RPS25/MRPS18A/MRPS34/MRPS15/MRPL20/MRPS18C/MRPS25/MRPL48/MRPL50/MRPL13/RPL29/MRPL32/MRPL24/MRPL38/MRPL30	13.6841088751589
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	54/869	138/9376	4.22194426377145	NDUFA4/MT-ND4/MT-CO2/UQCR11/COX8A/MT-ATP6/NDUFS2/ATP6V0C/NDUFS8/UQCR10/NDUFA13/NDUFB9/ATP6V1G1/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/ATP5F1D/NDUFC2/ATP5MC2/ATP6V1F/ATP5MG/COX7C/ATP5ME/NDUFB7/CYCS/NDUFAB1/ATP5MF/NDUFB4/COX7A2/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/COX5B/NDUFB3/ATP5PD/ATP5F1C/NDUFB11/UQCRB/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/ATP6AP1/COX6C/NDUFA1/NDUFA4L2	12.1864131463169
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	76/869	268/9376	3.05968431719424	MAOB/NDUFA4/CALM2/MT-ND4/TUBA1A/MT-CO2/UQCR11/COX8A/SNCAIP/MT-ATP6/NDUFS2/NDUFS8/UQCR10/NDUFA13/NDUFB9/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/DUSP1/NDUFA3/ATP5F1D/SLC25A5/NDUFC2/UBE2L6/ATP5MC2/COX7C/RPS27A/NDUFB7/CYCS/NDUFAB1/UBC/TUBA1B/NDUFB4/COX7A2/PSMB3/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/PSMB4/HSPA5/PSMA2/PSMA4/COX5B/XBP1/NDUFB3/PARK7/ATP5PD/ATP5F1C/NDUFB11/UQCRB/UBB/SLC39A4/UBA52/PSMA1/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/MAOA/PSMA5/COX6C/TUBB/NDUFA1/NDUFA4L2/SLC39A3/TXN/PPIF/BAX/SLC25A4	10.9336170404352
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	70/869	235/9376	3.21386773743359	ACTB/NDUFA4/CNR1/MT-ND4/MT-CO2/NDUFAF8/UQCR11/COX8A/MT-ATP6/NDUFS2/NDUFS8/UQCR10/NDUFA13/RHEB/NDUFB9/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/ATP5F1D/NDUFC2/ATP5MC2/ATP5MG/COX7C/ATP5ME/NDUFB7/NDUFAB1/ATP5MF/SMARCB1/NDUFB4/COX7A2/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/COX16/COX5B/NDUFB3/ATP5PD/ATP5F1C/NDUFB11/UQCRB/COA3/RPS6/CREB5/NDUFAF3/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/PLIN1/AKT1S1/PRKG2/COX14/COX6C/HRAS/RPS6KB2/CREB1/COX20/ACTL6A/FGFR1/NDUFA1/NDUFA4L2/PRKAG1	10.9848987438647
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	71/869	275/9376	2.78563029605607	HSPA1B/HSPA1A/NDUFA4/MT-ND4/TUBA1A/MT-CO2/UQCR11/COX8A/MT-ATP6/NDUFS2/NDUFS8/UQCR10/NDUFA13/NDUFB9/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/ATP5F1D/SLC25A5/NDUFC2/ATP5MC2/COX7C/NDUFB7/CYCS/NDUFAB1/TUBA1B/NDUFB4/CSNK2B/COX7A2/PSMB3/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/PSMB4/HSPA5/PSMA2/PSMA4/COX5B/NDUFB3/ATP5PD/ATP5F1C/NDUFB11/UQCRB/CREB5/PSMA1/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/PSMA5/COX6C/TUBB/CREB1/MAPK3/NDUFA1/NDUFA4L2/CAV2/PPIF/BAX/NCAM2/NOTCH1/RYR2/SLC25A4	9.60551480170755
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	57/869	205/9376	2.99998315978557	NDUFA4/REN/CTSD/MT-ND4/MT-CO2/UQCR11/COX8A/MT-ATP6/NDUFS2/PPP1CB/NDUFS8/UQCR10/NDUFA13/TGFBR1/NDUFB9/MMP9/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/ATP5F1D/SLC25A5/NDUFC2/ATP5MC2/COX7C/NDUFB7/NDUFAB1/NDUFB4/COX7A2/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/COX5B/NDUFB3/ATP5PD/ATP5F1C/NDUFB11/UQCRB/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/COX6C/PDK4/NDUFA1/NDUFA4L2/PDHB/PPIF/RYR2/SLC25A4	9.25341910565887
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	70/869	308/9376	2.45213934511978	NDUFA4/MT-ND4/POLR2K/TUBA1A/MT-CO2/POLR2I/UQCR11/COX8A/MT-ATP6/NDUFS2/NDUFS8/CLTB/UQCR10/NDUFA13/NDUFB9/POLR2J/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/ATP5F1D/SLC25A5/NDUFC2/ATP5MC2/COX7C/NDUFB7/CYCS/POLR2L/NDUFAB1/TUBA1B/NDUFB4/COX7A2/PSMB3/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/PSMB4/POLR2F/PSMA2/PSMA4/COX5B/NDUFB3/DCTN6/ATP5PD/ATP5F1C/NDUFB11/UQCRB/CREB5/PSMA1/DCTN3/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/PSMA5/COX6C/TUBB/CREB1/NDUFA1/NDUFA4L2/PPIF/BAX/SLC25A4	8.28199959935916
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	58/869	238/9376	2.6293527767839	RPS12/RPL35/RPS24/RPL13/ISG15/RPL36/RPS7/RPS10/RPLP1/RPL36AL/RPS8/RPL39/CCL2/RPL36A/RPS3A/RPL35A/RPL32/RPS15A/RPL26/RPL19/RPS18/RPS28/RPS15/RPL8/FAU/RPS3/RPL11/RPS19/RPL28/RPL34/RPS14/C1R/RPL41/RPLP2/RPL18/RPL38/RPL24/RPL21/RSL24D1/RPL14/RPS27A/RPL17/C3/RPS21/RPL27/MASP1/MX1/IFNAR2/RPL26L1/RPS6/RPL22/UBA52/RPS5/RPL22L1/RPS25/IRF9/RPL29/MAPK3	8.13739385767701
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	78/869	388/9376	2.16900573001317	WNT4/MME/NDUFA4/CALM2/WNT5A/MT-ND4/APOE/TUBA1A/MT-CO2/WNT6/UQCR11/COX8A/MT-ATP6/NDUFS2/NDUFS8/UQCR10/NDUFA13/NDUFB9/CDK5/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/ATP5F1D/SLC25A5/NDUFC2/DKK1/ATP5MC2/COX7C/NDUFB7/CYCS/NDUFAB1/PSENEN/TUBA1B/NDUFB4/CSNK2B/COX7A2/PSMB3/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/PSMB4/PSMA2/PSMA4/COX5B/XBP1/BACE2/NDUFB3/ATP5PD/ATP5F1C/NDUFB11/UQCRB/SLC39A4/PSMA1/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/PSMA5/COX6C/APH1A/HRAS/TUBB/MAPK3/NDUFA1/NDUFA4L2/SLC39A3/PPIF/FZD3/PPID/SLC25A4	7.51637225630271
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	43/869	157/9376	2.95506219169849	NDUFA4/MT-CO2/UQCR11/COX8A/NDUFS2/NDUFS8/UQCR10/NDUFA13/NDUFB9/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/NDUFC2/COX7C/NDUFB7/CYCS/NDUFAB1/NDUFB4/COX7A2/NDUFA7/NDUFS6/NDUFC1/COX7A2L/COX5B/XBP1/NDUFB3/NDUFB11/UQCRB/SDHC/NDUFS7/COX6A1/CYC1/NDUFB5/UQCRH/COX6C/NDUFA1/NDUFA4L2/ADIPOR1/BAX/PRKAG1	7.89543033401717
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/869	227/9376	2.47158362186523	NDUFA4/MT-ND4/MT-CO2/UQCR11/COX8A/MT-ATP6/NDUFS2/NDUFS8/UQCR10/NDUFA13/NDUFB9/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/ATP5F1D/SLC25A5/NDUFC2/ATP5MC2/COX7C/NDUFB7/NDUFAB1/NDUFB4/COX7A2/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/COX5B/NDUFB3/ATP5PD/ATP5F1C/NDUFB11/UQCRB/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/GSTT2B/COX6C/HRAS/MAPK3/NDUFA1/NDUFA4L2/PPIF/SLC25A4	7.17328969844881
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	84/869	480/9376	1.88814729574223	WNT4/NDUFA4/CALM2/WNT5A/MT-ND4/TUBA1A/MT-CO2/WNT6/UQCR11/COX8A/SNCAIP/MT-ATP6/NDUFS2/NDUFS8/UQCR10/NDUFA13/NDUFB9/CDK5/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/MAP1LC3A/ATP5F1D/SLC25A5/NDUFC2/UBE2L6/DKK1/ATP5MC2/COX7C/RPS27A/NDUFB7/CYCS/NDUFAB1/UBC/TUBA1B/NDUFB4/CSNK2B/COX7A2/PSMB3/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/PSMB4/HSPA5/PSMA2/PSMA4/COX5B/XBP1/NDUFB3/PARK7/DCTN6/ATP5PD/ATP5F1C/NDUFB11/UQCRB/UBB/UBA52/PSMA1/DCTN3/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/PSMA5/COX6C/HRAS/TUBB/MAPK3/NDUFA1/NDUFA4L2/PPIF/BAX/FZD3/PPID/RYR2/SLC25A4	6.38433311917444
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	68/869	368/9376	1.99369590233652	ACTB/NDUFA4/MT-ND4/TUBA1A/MT-CO2/PFN1/UQCR11/COX8A/MT-ATP6/NDUFS2/NDUFS8/UQCR10/NDUFA13/NDUFB9/COX7B/UQCRQ/COX6B1/NDUFA5/NDUFS4/NDUFA3/MAP1LC3A/ATP5F1D/NDUFC2/ANG/ATP5MC2/CHCHD10/COX7C/NXT1/NDUFB7/CYCS/NDUFAB1/TUBA1B/NDUFB4/COX7A2/PSMB3/NDUFA7/NDUFS6/ATP5MC3/NDUFC1/COX7A2L/PSMB4/HSPA5/PSMA2/PSMA4/COX5B/XBP1/NDUFB3/DCTN6/ATP5PD/ATP5F1C/NDUFB11/UQCRB/PSMA1/ALYREF/DCTN3/SDHC/NDUFS7/ATP5PF/COX6A1/CYC1/NDUFB5/UQCRH/PSMA5/COX6C/TUBB/NDUFA1/NDUFA4L2/BAX	6.21542069578165
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/869	31/9376	4.52459259809199	SEC11C/SEC61G/TMEM208/SRP9/SRP19/HSPA5/SEC11A/IMMP1L/SPCS1/GET1/SRP14/SPCS2/SGTA	6.28213737201191
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	25/869	110/9376	2.45213934511978	ID1/ID3/LEFTY2/CHRD/BAMBI/TGFBR1/SMAD9/SKP1/THBS1/LTBP1/RGMB/RBX1/ID2/FST/EMP3/MYC/GREM2/SMAD7/RPS6KB2/MAPK3/ACVR1C/E2F4/BMP4/E2F5/TMEM53	4.89627494638588
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	29/869	149/9376	2.09995288884083	NDUFA4/CNR1/MT-ND4/NDUFS2/NDUFS8/NDUFA13/NDUFB9/NDUFA5/NDUFS4/NDUFA3/NDUFC2/NDUFB7/NDUFAB1/NDUFB4/NDUFA7/NDUFS6/NDUFC1/GNG10/NDUFB3/NDUFB11/NDUFS7/GNB2/NDUFB5/GNG5/GNB5/MAPK3/NDUFA1/NDUFA4L2/ABHD6	4.32557920352766
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	19/869	87/9376	2.35630861209211	TPM1/MT-CO2/UQCR11/COX8A/TPM2/UQCR10/COX7B/UQCRQ/COX6B1/COX7C/COX7A2/COX7A2L/COX5B/UQCRB/COX6A1/CYC1/UQCRH/COX6C/RYR2	4.06200986945887
Genetic Information Processing	Transcription	hsa03040	Spliceosome	37/869	243/9376	1.64283245014609	HSPA1B/HSPA1A/RBM8A/SNRPD3/SNRPD1/LSM5/LSM7/SNRPD2/SNRPG/BCAS2/SF3B6/SNRPB2/SNRPF/LSM6/SNU13/LSM2/LSM3/TXNL4A/DDX39B/SRSF2/SNRPA1/SNRPA/CCDC12/ALYREF/PRPF6/SF3A2/SNRPE/SRSF9/LSM4/SNRPC/PPIL1/PPIH/MAGOHB/RP9/ZMAT2/SF3B4/THOC6	3.24490143732117
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/869	78/9376	2.07488713817828	LSM5/LSM7/EXOSC8/LSM6/LSM2/LSM3/BTG2/NUDT16/PFKP/C1D/DHX36/BTG3/LSM4/EXOSC9/EXOSC4	3.04665099255917
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/869	50/9376	2.37367088607595	CKB/MAOB/SMS/SRM/SMOX/SAT1/ODC1/MAOA/PYCR1/ARG1/PYCR2	3.11262857731311
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/869	88/9376	1.96171147609583	CFH/SERPING1/F3/C1R/PLAUR/CD55/TFPI/C3/CFI/SERPINE1/MASP1/F10/F2RL2/VTN/SERPINB2/THBD	2.89689224556017
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	18/869	105/9376	1.84961367746178	CCZ1B/CITED2/MAP1LC3A/MTX2/PHB2/RPS27A/GABARAPL2/MITF/UBC/CSNK2B/GABARAP/FKBP8/UBB/UBA52/RAB5C/HRAS/MRAS/RAB5B	2.79808023849934
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/869	63/9376	2.05512630829086	POLR2K/POLR2I/POLR2J/POLR2L/RBX1/POLR2F/GTF2H5/RAD23A/POLE4/POLD2/POLD4/RPA3	2.68557468854205
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/869	44/9376	2.2069254106078	VAMP2/ARHGDIA/RAB11B/DCTN6/CREB5/AQP3/RAB5C/CREB1/RAB5B	2.56464178735113
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/869	140/9376	1.61841196777906	ACTA2/MYLK/CALM2/KLF2/TGFBR1/MAP1LC3A/SERPINE1/GNG10/RPS6/MYLK3/GNB2/PLIN1/GNG5/SPHK1/GNB5/HRAS/RPS6KB2/MAPK3/MRAS/PRKAG1/RYR2	2.35617341448008
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	26/869	184/9376	1.52459098413969	WNT4/MYL9/SEMA3B/WNT5A/MYL12A/SEMA3A/CFL2/UNC5B/UNC5C/CDK5/SEMA3C/CFL1/EPHB6/EPHA2/SEMA7A/SEMA6D/DPYSL2/HRAS/ROBO2/EPHA6/MAPK3/ABLIM2/SEMA3F/SEMA4C/NTNG2/FZD3	2.29684683893858
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/869	52/9376	2.07488713817828	APOA1/NPC2/PLTP/APOC1/APOE/STARD3NL/VAPA/ANGPTL4/APOC3/TSPO	2.48410938542937
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/869	134/9376	1.61036016694433	ACTA2/MYLK/PLA2G2A/MYL9/CALM2/PPP1R14A/RAMP1/AVPR1A/RAMP3/PPP1CB/CALD1/KCNMA1/MYL6/KCNMB1/ADM/MYL6B/MYLK3/KCNMB4/ACTG2/MAPK3	2.27437938499763
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/869	46/9376	2.11097213188573	PSME2/PSMB9/PSMF1/PSMB3/PSMB4/PSMA2/PSMA4/PSMA1/PSMA5	2.4140628293782
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	10/869	56/9376	1.92668091402269	ST6GAL2/KRTCAP2/DDOST/DPM3/TMEM258/DPM2/RPN1/ALG3/B4GALT3/MOGS	2.2229187327639
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/869	34/9376	2.22134975969674	POLR3GL/POLR2K/POLR2I/POLR2J/POLR2L/POLR2F/POLR3C	2.2801682199575
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/869	34/9376	2.22134975969674	SKP1/RBX1/NR1D1/PER1/PER3/CREB1/PRKAG1	2.2801682199575
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	30/869	233/9376	1.38919482212795	SGCE/ACTB/TPM1/MYL9/PDLIM7/CSRP1/FHL2/ITGA1/TPM2/ZYX/FBN2/CAPZB/NID2/THBS1/CAPZA2/COL4A6/DSG2/PKP2/COL27A1/DMD/DAAM1/ELN/FHL3/PDLIM4/ACTG2/ITGA6/ITGA3/SGCZ/CSRP2/DES	1.92268423089589
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	13/869	85/9376	1.65014553577472	UPP1/NME1/NUDT16/CDA/AK2/AK6/CMPK1/HPRT1/NT5C3B/PNP/ENTPD3/AK1/AK4	1.92440345369048
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/869	248/9376	1.34867663981588	ACTB/MYL9/RPS3/MYL12A/DYNLT1/TUBA1A/PFN1/DYNLRB1/DYNLT3/SKP1/CYCS/TUBA1B/ARF6/S100A10/RHOB/DCTN6/ARHGEF26/DCTN3/RAB5C/RAB9A/ARPC1B/MYC/LEF1/HRAS/TUBB/ARPC3/KPNA1/MAPK3/RAB5B/TXN/BAX	1.77855863226588
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/869	86/9376	1.63095779698665	SGCE/ACTB/ITGA1/CTNNA3/DSG2/PKP2/DMD/LEF1/ITGA6/ITGA3/SGCZ/RYR2/DES	1.87866346728856
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	31/869	250/9376	1.33788722669735	NPC2/LAPTM4A/CTSD/BORCS7/CD68/ATP6V0C/CLTB/ATP6V1G1/CTSC/CTSH/AGA/ATP6V1F/GPR155/ACP5/MITF/LAMTOR2/DEPTOR/LAMP5/BLOC1S1/FUCA2/SLC29A1/CTSK/AKT1S1/ATP6AP1/GNPTG/ACP2/TMEM175/BORCS8/CLN3/KXD1/HEXB	1.73064844460988
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/869	54/9376	1.79823551975451	ADI1/MDH2/CISD1/SMS/SRM/MPST/AHCY/LDHB/BCAT2	1.88009887555649
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/869	97/9376	1.55723488308638	CALM2/NOS1AP/RASD1/GNG10/GNB2/PER1/GNG5/PRKG2/GNB5/PER3/CREB1/MAPK3/CACNA1H/RYR2	1.76311599499587
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/869	106/9376	1.52680374318779	PDGFD/IGF1/MMP9/PDGFRA/GSTP1/CREB5/LEF1/HRAS/CREB1/MAPK3/FGFR1/SLC19A1/ERG/IL1R2/CDKN1B	1.74328834948584
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/869	47/9376	1.83649584996205	ACAT2/MDH2/LDHB/ADH5/GLO1/PDHB/HAGH/ADH1C	1.83739480075848
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	22/869	174/9376	1.36417867015859	HSPA1B/HSPA1A/PPP1R15A/SEC61G/SSR4/KRTCAP2/BCAP31/DDOST/PDIA6/SKP1/RBX1/HSPA5/XBP1/RNF5/RAD23A/TMEM258/LMAN2/RPN1/SSR2/BAG2/MOGS/BAX	1.54972744901398
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	25/869	203/9376	1.32874545794668	MYLK/ACTB/ACTN1/MYL9/PDGFD/MYL12A/ITGA1/IGF1/PPP1CB/ZYX/LAMA4/PDGFRA/THBS1/COL4A6/EMP1/MYLK3/PARVA/VTN/VEGFB/HRAS/EMP2/ITGA6/MAPK3/ITGA3/CAV2	1.51341973688427
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/869	93/9376	1.50819753269733	ACTB/ACTN1/MYL9/MYL12A/SORBS1/TGFBR1/NECTIN2/CSNK2B/CTNNA3/PDCD10/LEF1/MAPK3/FGFR1	1.57411755126659
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/869	157/9376	1.37444753102255	ID1/WNT4/ACTB/WNT5A/WNT6/PPP1CB/TGFBR1/YWHAE/NKD1/CTNNA3/SERPINE1/CRB2/AREG/ID2/MYC/NKD2/SMAD7/LEF1/BMP4/FZD3	1.51218943698403
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/869	59/9376	1.64584267909735	GGT5/GPX4/SMS/SRM/GSTP1/PRDX6/ODC1/PGD/GSTT2B	1.5904572827936
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	20/869	158/9376	1.36574849601608	WNT4/WNT5A/WNT6/IGF1/RHEB/ATP6V1G1/ATP6V1F/PRR5/CAB39L/LAMTOR2/DEPTOR/SLC3A2/RPS6/SGK1/EIF4EBP1/AKT1S1/HRAS/RPS6KB2/MAPK3/FZD3	1.4818356900156
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/869	51/9376	1.69245695976895	ACTB/SEC61G/KDELR1/ATP6V0C/ATP6V1G1/ATP6V1F/TJP2/ATP6AP1	1.58475000741302
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/869	20/9376	2.15788262370541	SC5D/TM7SF2/HSD17B7/EBP	1.65669185786715
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/869	44/9376	1.71649754158385	KRTCAP2/DDOST/TMEM258/RPN1/ALG3/B4GALT3/HEXB	1.52251292377289
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/869	28/9376	1.92668091402269	PCBD1/PTS/MOCS2/DHFR/AKR1B1	1.56948508241801
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	29/869	250/9376	1.25157192174914	HSPA1B/HSPA1A/RAB11FIP1/RAB31/CHMP1B/PSD/CLTB/TGFBR1/CAPZB/SMAP1/WIPF1/CHMP5/MVB12A/PDGFRA/CAPZA2/ARF6/RAB11B/WASHC1/HLA-F/GRK5/RAB5C/ARPC1B/SPG21/EHD4/HRAS/ARPC3/SMAP2/CAV2/RAB5B	1.28854398947918
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/869	37/9376	1.74963455976114	MAOB/MIF/COMT/MAOA/ADH5/ADH1C	1.46018399752406
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/869	37/9376	1.74963455976114	MYC/LEF1/HRAS/CCDC6/MAPK3/BAX	1.46018399752406
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/869	99/9376	1.41679162162476	SGCE/ACTB/TPM1/ITGA1/IGF1/TPM2/DMD/ITGA6/ITGA3/SGCZ/PRKAG1/RYR2/DES	1.33241682839059
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/869	155/9376	1.32257322098073	ACTB/SEC61G/C1R/TUBA1A/ATP6V0C/ATP6V1G1/ATP6V1F/C3/THBS1/TUBA1B/STX12/HLA-F/COLEC11/RAB5C/ATP6AP1/TUBB/MRC2/RAB5B/STX7	1.29423296938506
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/869	14/9376	2.31201709682722	B4GALT3/B3GNT2/CHST1	1.57009707239057
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	40/869	362/9376	1.19220034458862	PRL/PDGFD/IGF2/ITGA1/IGF1/RHEB/LAMA4/YWHAE/PDGFRA/THBS1/PRLR/CDC37/IFNAR2/COL4A6/NR4A1/GNG10/RPS6/CREB5/AREG/EPHA2/SGK1/EIF4EBP1/GNB2/MYC/GNG5/VTN/GHR/VEGFB/GNB5/HRAS/RPS6KB2/CREB1/NGF/ITGA6/MAPK3/FGFR1/ITGA3/G6PC3/PPP2R3C/CDKN1B	1.19194709738392
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	19/869	157/9376	1.30572515447143	IGFBP3/CALM2/PPP1CB/TGFBR1/RHEB/SLC25A5/SERPINE1/HLA-F/EIF4EBP1/MYC/HRAS/MAPK3/ZFP36L1/MRAS/NBN/E2F4/E2F5/PPID/SLC25A4	1.23465722406955
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	13/869	101/9376	1.38873634198863	CCL2/F3/TGFBR1/SERPINE1/COL4A6/PIM1/VEGFB/SELE/HRAS/MAPK3/BAX/CDKN1B/THBD	1.25535391522673
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	23/869	196/9376	1.26610460064348	ZFP36/CALM2/MAP1LC3A/RPS27A/CYCS/C3/UBC/IFNAR2/GNG10/UBB/HLA-F/UBA52/IRF9/IRF7/GNB2/MYC/GNG5/GNB5/LEF1/HRAS/CREB1/MAPK3/BAX	1.20327914087256
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/869	75/9376	1.43858841580361	IGFBP3/RPRM/IGF1/CYCS/THBS1/EI24/SERPINE1/AIFM2/STEAP3/BAX	1.21879391208231
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/869	15/9376	2.15788262370541	ST6GALNAC3/ST3GAL5/HEXB	1.43435401518177
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/869	15/9376	2.15788262370541	AK2/AK1/AK4	1.43435401518177
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/869	76/9376	1.41965962085882	APOA1/FABP5/PLTP/SORBS1/UBC/ANGPTL4/SLC27A5/PLIN1/APOC3/DBI	1.17400464661455
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/869	41/9376	1.5789385051503	BABAM2/POLD2/POLD4/RAD51C/RPA3/NBN	1.18733839727074
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/869	144/9376	1.27375015982611	ID1/ID3/WNT4/LEFTY2/WNT5A/WNT6/IGF1/SMAD9/ID2/MYC/HRAS/TBX3/MAPK3/ACVR1C/FGFR1/BMP4/FZD3	1.05802283138917
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/869	16/9376	2.02301495972382	MAOB/MIF/MAOA	1.30891474926713
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	18/869	154/9376	1.26110023463303	NME1/DHRS3/PTS/MTHFD2/MOCS2/AK2/AK6/CMPK1/COQ2/DHFR/HSD17B6/AK1/GMPPB/MMAB/NAPRT/AK4/BCAT2/PNPO	1.04414875165914
NA	NA	hsa04518	Integrin signaling	18/869	154/9376	1.26110023463303	ACTB/ACTN1/PDGFD/ITGA1/IGF1/LIMS2/LAMA4/FERMT1/PDGFRA/C3/THBS1/FREM1/COL4A6/PARVA/VTN/VEGFB/ITGA6/ITGA3	1.04414875165914
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	36/869	333/9376	1.16642303984076	ISG15/WNT4/WNT5A/WNT6/ITGA1/ATP6V0C/RHEB/HES4/ATP6V1G1/LAMA4/BCAP31/ATP6V1F/THBS1/MX1/IFNAR2/COL4A6/CREB5/HLA-F/LFNG/EIF4EBP1/IRF9/VTN/ATP6AP1/HRAS/RPS6KB2/CREB1/TUBG1/ITGA6/MAPK3/ITGA3/PPP2R3C/HES1/BAX/FZD3/NOTCH1/CDKN1B	0.988295031023647
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/869	42/9376	1.54134473121815	FTH1/GPX4/MAP1LC3A/SAT1/SLC3A2/STEAP3	1.12375586453261
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/869	80/9376	1.34867663981588	PDGFD/IGF1/PDGFRA/GAS6/RPS6/EIF4EBP1/HRAS/RPS6KB2/MAPK3/BAX	1.00098391332458
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/869	17/9376	1.90401407974007	GLUL/CA12/CA4	1.19231838768036
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/869	17/9376	1.90401407974007	PCDH7/PCDH20/NRP2	1.19231838768036
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/869	90/9376	1.31870604781997	IGF1/RHEB/CREB5/EIF4EBP1/AKT1S1/HRAS/RPS6KB2/CREB1/ADIPOR1/BAX/PRKAG1	0.970967134071262
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/869	100/9376	1.29472957422324	CCL2/CCL3/CCL8/ACKR3/LTBR/CXCL14/CCL21/CCL23/IL10RB/CCL14/CXCL13/ACKR4	0.947001477843577
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/869	110/9376	1.27511245946229	ELOB/IGF1/LTBR/SERPINE1/RBX1/PFKP/RPS6/EIF4EBP1/LDHB/RPS6KB2/MAPK3/PDHB/CDKN1B	0.927615002809999
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/869	82/9376	1.31578208762525	HSPA1B/HSPA1A/B2M/PSME2/HSPA2/KLRC3/HSPA5/TAPBPL/HLA-F/CREB1	0.917910618082789
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/869	18/9376	1.79823551975451	AGA/FUCA2/HEXB	1.08338568081582
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/869	10/9376	2.15788262370541	ETHE1/MPST	1.17083250202956
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/869	36/9376	1.49852959979542	RNASEH2C/POLE4/POLD2/POLD4/RPA3	0.957802732257972
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/869	122/9376	1.2381293742572	IGF1/RHEB/CAB39L/RAB11B/PFKP/CREB5/EIF4EBP1/AKT1S1/RPS6KB2/CREB1/G6PC3/PPP2R3C/ADIPOR1/PRKAG1	0.846126795195482
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	27/869	253/9376	1.15143934466494	ACTB/ACTN1/MYL9/MYL12A/PFN1/MAP1LC3A/SKP1/RPS27A/CYCS/C3/UBC/ARF6/UBE2N/RBX1/UBB/UBA52/ARPC1B/AKT1S1/CBX3/TIFA/RPS6KB2/ARPC3/MAPK3/UBE2V2/SHARPIN/BAX/PPID	0.780436288304344
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/869	133/9376	1.21685110359328	DEPP1/KLF2/IGF1/TGFBR1/GABARAPL2/PRMT1/GABARAP/PLK3/SGK1/HRAS/MAPK3/G6PC3/HOMER2/PRKAG1/CDKN1B	0.804985932018264
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	22/869	204/9376	1.16356415984115	WNT4/ACTB/WNT5A/WNT6/IGF2/PLAUR/IGF1/PPP1CB/MMP9/THBS1/TWIST1/RPS6/LUM/MYC/VTN/HRAS/RPS6KB2/MAPK3/FGFR1/MRAS/CAV2/FZD3	0.754881040656588
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/869	105/9376	1.23307578497452	SGCE/ACTB/TPM1/ITGA1/IGF1/TPM2/DMD/ITGA6/ITGA3/SGCZ/RYR2/DES	0.767601517384071
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/869	166/9376	1.16993636224992	MYLK/MYL9/CALM2/RGS2/PPP1CB/ADRA2C/KCNMA1/KCNJ8/SLC25A5/KCNMB1/CREB5/MYLK3/PRKG2/CREB1/KCNMB4/MAPK3/PPIF/SLC25A4	0.706021385689216
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/869	156/9376	1.17576937830102	CLDN10/CLDN4/YWHAE/CD81/CYCS/EIF3E/MX1/IFNAR2/OCLN/IRF9/IRF7/MYC/HRAS/MAPK3/IFIT1/BAX/RSAD2	0.707534082943846
NA	NA	hsa03272	Virion - Hepatitis viruses	6/869	48/9376	1.34867663981588	CLDN10/CHMP1B/CLDN4/EPCAM/CD81/OCLN	0.774027716166296
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	17/869	157/9376	1.16828040136917	GULP1/MFGE8/THBS1/GAS6/DUSP5/CEBPB/ODC1/BSG/RAB5C/SGK1/SPHK1/DUSP8/CREB1/MAPK3/NR1H2/RAB5B/ARG1	0.679592798240577
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	19/869	178/9376	1.1516789283821	WNT4/WNT5A/WNT6/BAMBI/LGR4/DKK1/SKP1/NKD1/CSNK2B/RBX1/TLE2/DAAM1/MYC/NKD2/LEF1/CTNNBIP1/CBY1/FZD3/SFRP1	0.652973956838107
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/869	68/9376	1.26934271982671	PIM1/EIF4EBP1/MYC/LEF1/HRAS/RPS6KB2/MAPK3/RARA	0.712424457548501
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/869	49/9376	1.32115262675841	MAOB/CDK5/CREB5/MAOA/CREB1/GPSM1	0.720353781231352
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/869	30/9376	1.43858841580361	MDH2/SDHC/IDH3B/PDHB	0.768974973408225
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	18/869	169/9376	1.14916826114489	CTSD/RHEB/MAP1LC3A/RPS27A/GABARAPL2/UBC/GABARAP/DEPTOR/UBB/UBA52/HMGB1/AKT1S1/HRAS/RPS6KB2/MAPK3/MRAS/RAB33B/STX7	0.625414603627675
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/869	59/9376	1.28009986152016	NUDT2/UPP1/NME1/CDA/CMPK1/NT5C3B/ENTPD3	0.689776131374353
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/869	89/9376	1.21229360882326	PDGFD/TUBA1A/PDGFRA/TUBA1B/HTR2A/PRKG2/HRAS/TUBB/MAPK3/MAPK7	0.643134060248324
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/869	99/9376	1.19882367983634	PDGFD/RHEB/PLPP3/PDGFRA/CHPT1/DGKB/EIF4EBP1/HRAS/RPS6KB2/MAPK3/DGKE	0.635607826913044
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/869	50/9376	1.29472957422324	CCL2/KLRB1/ACKR1/CD81/THBS1/SELE	0.667833688990244
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/869	31/9376	1.39218233787446	RBKS/PFKP/PGD/RPIA	0.699015064248237
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/869	31/9376	1.39218233787446	ACAT2/MDH2/GLUL/MCEE	0.699015064248237
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/869	41/9376	1.31578208762525	MMP9/THBS1/MYC/HRAS/MAPK3	0.647633892843993
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	11/869	101/9376	1.1750845970673	WNT4/CALM2/WNT5A/WNT6/MITF/ASIP/LEF1/HRAS/CREB1/MAPK3/FZD3	0.565404133042856
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/869	22/9376	1.47128360707187	MAOB/HNMT/MAOA	0.70729779041181
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/869	71/9376	1.21570852039741	PDGFRA/PFKP/LDHB/MYC/HRAS/MAPK3/FGFR1/PDHB	0.583103429268075
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/869	142/9376	1.13972673787257	ELOB/UBE2M/UBE2L6/SKP1/RPS27A/UBC/UBE2N/RBX1/ANAPC15/UBB/UBA52/ANAPC13/UBE2S/ANAPC10/UBE2A	0.536211429715289
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/869	142/9376	1.13972673787257	ACTB/CCL2/CALM2/KLF2/MMP9/DUSP1/GSTP1/GSTT2B/SELE/MAPK7/CAV2/BMP4/TXN/IL1R2/THBD	0.536211429715289
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/869	194/9376	1.11231063077598	ACTA2/ACTB/TPM1/MYL9/MYL12A/DYNLT1/TUBA1A/TPM2/DYNLRB1/DYNLT3/MYL6/CAPZB/TUBA1B/CAPZA2/DCTN6/MYL6B/DCTN3/TUBB/TUBG1/ACTG2	0.505196574531838
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/869	62/9376	1.21815954564015	HSPA1B/HSPA1A/IGF1/AKT1S1/HRAS/RPS6KB2/PRKAG1	0.550819438793909
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	23/869	227/9376	1.0932004481327	CCL2/B2M/CCL3/CALM2/RHEB/CYCS/PDGFRA/IL10RB/GNG10/TAPBPL/CREB5/HLA-F/EIF4EBP1/GNB2/MYC/GNG5/GNB5/HRAS/RPS6KB2/CREB1/MAPK3/PTGER3/BAX	0.454309088894107
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/869	23/9376	1.40731475459048	ACAT2/RCE1/PDSS1	0.625066038448947
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/869	23/9376	1.40731475459048	POLD2/POLD4/RPA3	0.625066038448947
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/869	73/9376	1.1824014376468	PDGFD/IGF1/PDGFRA/MITF/HRAS/MAPK3/FGFR1/BAX	0.500017824955959
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/869	63/9376	1.19882367983634	WNT4/WNT5A/WNT6/LEF1/BMP4/BAX/FZD3	0.506058694447853
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/869	43/9376	1.25458292075896	APOA1/PLA2G2A/ACAT2/PLPP3/AGPAT2	0.534761545321031
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/869	44/9376	1.22606967255989	HMGB1/POLE4/POLD2/POLD4/SMUG1	0.48038406019466
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	12/869	116/9376	1.11614618467521	ACAT2/MDH2/ESD/PFKP/PGD/SDHC/ADH5/MCEE/IDH3B/RPIA/PDHB/ACADS	0.402286778532638
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/869	75/9376	1.15087073264288	PFKP/GLUL/IDH3B/RPIA/PYCR1/ARG1/BCAT2/PYCR2	0.419254872748132
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	18/869	180/9376	1.0789413118527	BST2/CCL2/B2M/PPP1CB/RHEB/NECTIN2/CYCS/C3/IFNAR2/TAPBPL/SRSF2/HLA-F/ALYREF/EIF4EBP1/IRF9/IRF7/SRSF9/BAX	0.341781396959378
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	17/869	170/9376	1.0789413118527	ACTB/CLDN10/ACTN1/MYL9/MYL12A/TUBA1A/CLDN4/MYL6/MPDZ/TUBA1B/TJP2/OCLN/MYL6B/ARPC1B/ARPC3/SYNPO/PRKAG1	0.331971365382576
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	17/869	170/9376	1.0789413118527	WNT4/ACTB/WNT5A/WNT6/IGF2/TGFBR1/SMARCB1/GSTP1/MYC/GSTT2B/LEF1/HRAS/RPS6KB2/ACTL6A/MAPK3/BAX/FZD3	0.331971365382576
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/869	35/9376	1.23307578497452	PFKP/HSD17B14/GMPPB/AKR1B1	0.441511278001358
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	14/869	139/9376	1.08670347956387	HSPA1B/HSPA1A/CTSD/CALM2/KRT23/MMP9/KRT18/CREB5/KRT10/HRAS/CREB1/MAPK3/RARA/KRT17	0.329143865451107
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/869	87/9376	1.11614618467521	TGFBR1/CYCS/AREG/MYC/LEF1/HRAS/RPS6KB2/MAPK3/BAX	0.347846311852999
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/869	98/9376	1.10096052229868	MARCKSL1/CFL2/PLPP3/ARF6/CFL1/ARPC1B/SPHK1/RPS6KB2/ARPC3/MAPK3	0.321103287840146
NA	NA	hsa04517	IgSF CAM signaling	29/869	299/9376	1.046464817516	MYLK/ACTB/ACTN1/MYL9/MYL12A/TUBA1A/SORBS1/UNC5B/MYL6/UNC5C/NECTIN2/MPDZ/PMP22/TUBA1B/ARF6/TJP2/MYL6B/MYLK3/ARPC1B/ROBO2/TUBB/ARPC3/MAPK3/FGFR1/NRP2/NFASC/CNTNAP2/PTPRZ1/NCAM2	0.260973236952851
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/869	130/9376	1.0789413118527	ACTA2/TGFBR1/MMP9/COL4A6/GNG10/CREB5/GNB2/GNG5/VEGFB/GNB5/HRAS/CREB1/MAPK3	0.289671908629003
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/869	99/9376	1.08983970894213	CFH/C1R/KRT23/CAMP/KRT18/C3/CFI/MASP1/KRT10/KRT17	0.287203326174272
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/869	78/9376	1.10660647369508	ACTB/CLTB/CTNNA3/ARHGEF26/ARPC1B/ARPC3/SEPTIN1/CAV2	0.302164485330815
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/869	154/9376	1.05091686219419	MYLK/ACTB/MYL9/CALM2/RGS2/PPP1CB/MYL6/MYL6B/MYLK3/HRAS/MAPK3/CD38/MAPK7/PRKAG1/RYR2	0.203618270099176
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/869	48/9376	1.12389719984657	ACAT2/HIBADH/MCEE/ACADS/BCAT2	0.275039551509036
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/869	59/9376	1.09722845273156	CTNNA3/MYC/LEF1/HRAS/MAPK3/BAX	0.239435555664727
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/869	38/9376	1.13572769668706	BST1/PNP/CD38/NAPRT	0.267941912338601
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/869	70/9376	1.0789413118527	SGCE/ACTB/CD55/CYCS/DMD/HLA-F/SGCZ	0.211874721744811
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/869	17/9376	1.26934271982671	CYP39A1/SLC27A5	0.355240349275939
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/869	28/9376	1.15600854841361	ATP6V0C/ATP6V1G1/ATP6V1F	0.264225890227904
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/869	103/9376	1.0475158367502	RBM8A/PPP1CB/NXT1/PABPN1/DDX39B/ALYREF/SAP18/MAGOHB/PPP2R3C/NUDT21	0.154972334054881
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	22/869	232/9376	1.02313400261894	RGCC/MYLK/ACTB/ACTN1/MYL9/PDGFD/MYL12A/CFL2/ITGA1/PFN1/PPP1CB/PDGFRA/CFL1/MYLK3/ARPC1B/HRAS/ARPC3/ITGA6/MAPK3/FGFR1/ITGA3/MRAS	0.114033899102591
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/869	93/9376	1.04413675340584	LAMA4/CYCS/COL4A6/MYC/TRAF4/ITGA6/ITGA3/BAX/CDKN1B	0.136711482685299
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/869	298/9376	1.01377036013006	PRL/IL1RL1/CCL2/CCL3/CCL8/ACKR3/LTBR/TGFBR1/CXCL14/CLCF1/CCL21/CCL23/PRLR/IL10RB/TNFRSF4/IFNAR2/CCL14/TNFRSF8/CXCL13/IL13RA1/TNFRSF18/TNFRSF21/GHR/NGF/ACVR1C/ACKR4/BMP4/IL1R2	0.0772085953020828
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	15/869	158/9376	1.02431137201206	CDKN2C/CDKN1C/YWHAE/SKP1/CDC7/RBX1/ANAPC15/ANAPC13/MYC/ANAPC10/ORC3/WEE1/E2F4/E2F5/CDKN1B	0.0984978998222169
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/869	18/9376	1.19882367983634	CD320/MMAB	0.269848587805319
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/869	137/9376	1.02381292365585	ACTB/CTSD/TUBA1A/CTSC/CTSH/CYCS/TUBA1B/CTSK/HRAS/NGF/MAPK3/BAX/DAB2IP	0.0897362319992945
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/869	148/9376	1.02062015986067	WNT4/WNT5A/WNT6/IGF1/MYC/LEF1/HRAS/RPS6KB2/MAPK3/FGFR1/HES1/BAX/FZD3/NOTCH1	0.0808121018802683
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	21/869	224/9376	1.01150747986191	B2M/ZFP36/CDKN2C/LTBR/TGFBR1/ETS2/RANBP1/SLC25A5/ANAPC15/CREB5/HLA-F/ANAPC13/MYC/ANAPC10/HRAS/CREB1/MAPK3/TSPO/BAX/IL1R2/SLC25A4	0.0557126141617101
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	17/869	181/9376	1.01337029290033	CTSD/CALM2/ATP6V0C/CAMP/CYCS/C3/IL10RB/PLK3/CEBPB/RAB5C/SPHK1/ATP6AP1/CREB1/MAPK3/MRC2/RAB5B/BAX	0.0580512602029867
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/869	51/9376	1.05778559985559	PLA2G7/PLA2G2A/PLPP3/CHPT1/PAFAH1B3	0.132247540453737
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/869	62/9376	1.04413675340584	PSENEN/TLE2/LFNG/APH1A/HES1/NOTCH1	0.111438542236848
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	20/869	214/9376	1.00835636621748	BST2/B2M/CALM2/ELOB/CFL2/SKP1/CYCS/RBX1/GNG10/TAPBPL/CFL1/HLA-F/GNB2/GNG5/GNB5/HRAS/RPS6KB2/WEE1/MAPK3/BAX	0.0395217819414256
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/869	149/9376	1.01377036013006	GRM7/PDGFD/AVPR1A/RHEB/PLPP3/PDGFRA/ARF6/DGKB/AGPAT2/SPHK1/HRAS/MAPK3/MRAS/DGKE	0.054152122339017
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/869	73/9376	1.03460125794095	MAOB/CYP3A5/GSTP1/GSTT2B/MAOA/ADH5/ADH1C	0.0948525733107192
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/869	107/9376	1.00835636621748	CALM2/PRMT1/PPP4C/PFKP/CREB5/LDHB/CREB1/G6PC3/PDHB/PRKAG1	0.0277843488035761
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	22/869	238/9376	0.997340708435273	PLA2G2A/CALM2/PDGFD/IGF2/IGF1/ETS2/RASGRP2/PDGFRA/ARF6/GNG10/EPHA2/RAB5C/GNB2/GNG5/VEGFB/GNB5/HRAS/NGF/MAPK3/FGFR1/MRAS/RAB5B	-0.0132811648606243
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	16/869	173/9376	0.997864797089206	ACTB/CCL2/SLC25A5/NXT1/CYCS/RAB11B/MX1/IFNAR2/PABPN1/IRF9/IRF7/KPNA1/MAPK3/BAX/RSAD2/SLC25A4	-0.00905951197529432
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/869	86/9376	1.00366633660717	KCNMA1/VAMP2/KCNMB1/CREB5/ABCC8/CREB1/KCNMB4/RYR2	0.0109164395393192
NA	NA	hsa04519	Cadherin signaling	37/869	404/9376	0.98813932026114	WNT4/ACTB/ACTN1/WNT5A/KRT23/WNT6/PCDH7/PPP1CB/CDH3/YWHAE/KRT18/MPDZ/PCDHB16/PDGFRA/PSENEN/CTNNA3/DSG2/PKP2/CDH13/DAAM1/KRT10/LIMA1/PCDH20/ARPC1B/KRT81/PCDH17/APH1A/LEF1/HRAS/ARPC3/MAPK3/FGFR1/MRAS/KRT17/CDH26/FZD3/DES	-0.0778866347015296
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/869	142/9376	0.987763172822898	FHL2/JUNB/JUND/TGFBR1/FOSL2/ACP5/MITF/IFNAR2/IRF9/CTSK/CREB1/MAPK3/LILRB3	-0.0469597064650321
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/869	20/9376	1.0789413118527	CYB5R2/GMPPB	0.112948779019764
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/869	65/9376	0.995945826325573	PLPP3/LCLAT1/DGKB/AGPAT2/DGKE/AKR1B1	-0.0104825797289423
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/869	43/9376	1.00366633660717	ACAT2/ADH5/ACADS/ADH1C	0.00770128578881322
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/869	99/9376	0.980855738047913	CDKN2C/IGF1/MMP9/HRAS/RPS6KB2/MAPK3/BAX/NOTCH1/CDKN1B	-0.0612011745645004
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/869	32/9376	1.01150747986191	PFKP/G6PC3/AKR1B1	0.0208399228974682
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/869	32/9376	1.01150747986191	LDHB/MCEE/ACADS	0.0208399228974682
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/869	66/9376	0.980855738047913	CYP3A5/COMT/HSD17B1/HSD17B7/HSD17B6/HSD11B1	-0.0498819089635652
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/869	133/9376	0.97348088287462	MAOB/CALM2/PPP1CB/GNG10/CREB5/COMT/GNB2/MAOA/GNG5/GNB5/CREB1/PPP2R3C	-0.0984431984054572
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/869	122/9376	0.972815936916373	WNT4/ACTB/RHEB/PFKP/DIO3/MED30/MYC/HRAS/MAPK3/BMP4/NOTCH1	-0.0965910411056557
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/869	55/9376	0.980855738047913	PLPP3/DEGS1/CERS4/SPHK1/HEXB	-0.0455088675833417
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/869	89/9376	0.969834887058611	ITGA1/LAMA4/THBS1/FREM1/COL4A6/VTN/ITGA6/ITGA3	-0.091383870062692
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/869	78/9376	0.968280664483196	SERPING1/CALM2/C1R/CFL2/C3/CFL1/MAPK3	-0.0899050157018064
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/869	67/9376	0.966216100166601	PFKP/LDHB/ADH5/G6PC3/PDHB/ADH1C	-0.0886957840207211
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/869	33/9376	0.980855738047913	IDH3B/PDHB/BCAT2	-0.0352094899338062
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/869	33/9376	0.980855738047913	VAMP2/USE1/STX7	-0.0352094899338062
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/869	79/9376	0.956023947211257	ATP6V0C/CLTB/ATP6V1G1/VAMP2/ATP6V1F/SLC1A1/NAPA	-0.125448561437191
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/869	136/9376	0.952007039870033	HSPA1B/HSPA1A/CYCS/CSNK2B/TNFAIP3/MX1/IFNAR2/IRF9/RAB9A/IRF7/BAX/CDKN1B	-0.180184868003879
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/869	69/9376	0.938209836393656	MAOB/CALM2/PPP1CB/CREB5/MAOA/CREB1	-0.164644164873998
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/869	115/9376	0.938209836393656	MAOB/DUSP1/GNG10/HTR2A/GNB2/MAOA/GNG5/GNB5/HRAS/MAPK3	-0.213081935619292
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	12/869	138/9376	0.938209836393656	CALM2/SORBS1/PPP1CB/RHEB/SOCS2/RPS6/EIF4EBP1/HRAS/RPS6KB2/MAPK3/G6PC3/PRKAG1	-0.233709959092837
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/869	104/9376	0.933699212180225	PLA2G2A/PLPP3/CHPT1/LCLAT1/DGKB/AGPAT2/DGKE/CRLS1/GDPD5	-0.217298114090818
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/869	93/9376	0.928121558582972	CALM2/KCNMA1/CAMP/VAMP2/BST1/SLC4A2/PRKG2/CD38	-0.222640034460023
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/869	23/9376	0.938209836393656	GLUL/ARG1	-0.0948233088667794
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/869	23/9376	0.938209836393656	MME/REN	-0.0948233088667794
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/869	150/9376	0.935082470272344	WNT4/WNT5A/WNT6/TGFBR1/CTNNA3/MYC/LEF1/HRAS/RPS6KB2/MAPK3/BAX/FZD3/CDKN1B	-0.256158162879683
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/869	116/9376	0.930121820562676	ACTB/CLDN10/ACTN1/MYL9/MYL12A/CLDN4/MMP9/THY1/CTNNA3/OCLN	-0.242031778953186
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/869	116/9376	0.930121820562676	GRM7/GNG10/SLC1A1/GLUL/GNB2/GNG5/GNB5/MAPK3/HOMER2/SHANK3	-0.242031778953186
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/869	82/9376	0.921047461337674	UPP1/NME1/CDA/GSTP1/GSTT2B/CMPK1/HPRT1	-0.229498050721437
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/869	128/9376	0.927215189873418	NUDT2/PDE4B/NME1/NUDT16/AK2/AK6/HPRT1/PNP/ENTPD3/AK1/AK4	-0.264989787999343
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/869	94/9376	0.918247924981025	CCL2/JUND/MMP9/TNFAIP3/CEBPB/TRAF4/MAPK3/MAPK7	-0.25459463019269
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	10/869	117/9376	0.922172061412568	ACTB/MORF4L2/SMARCB1/CECR2/MEAF6/INO80C/DMAP1/TFPT/ACTL6A/CDK2AP2	-0.270740811546927
NA	NA	hsa04081	Hormone signaling	19/869	219/9376	0.936067804803716	PRL/RAMP1/IGF2/AVPR1A/RAMP3/IGF1/ADRA2C/VIPR2/SMAD9/PRLR/GNG10/GNB2/GNG5/GHR/PRKG2/GNB5/NPR3/ADIPOR1/PENK	-0.305965442205571
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/869	95/9376	0.908582157349646	CCL2/CCL3/ATP6V0C/ATP6V1G1/ATP6V1F/ACP5/CTSK/ATP6AP1	-0.286221790765354
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/869	24/9376	0.899117759877254	B3GAT3/HS6ST2	-0.158152258815144
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/869	187/9376	0.923158341692153	CCL2/GBP1/CAMP/YWHAE/MAP1LC3A/GABARAPL2/TXNIP/TNFAIP3/GABARAP/IFNAR2/IRF9/IRF7/GPSM3/MAPK3/TXN/SHARPIN	-0.33922723793787
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	26/869	300/9376	0.935082470272344	HSPA1B/HSPA1A/PDGFD/IGF2/IGF1/JUND/TGFBR1/STMN1/RASGRP2/DUSP1/PDGFRA/NR4A1/DUSP5/AREG/EPHA2/MYC/VEGFB/DUSP8/HRAS/HSPB1/NGF/MAPK3/FGFR1/MRAS/MAPK7/CACNA1H	-0.365243654279053
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/869	119/9376	0.906673371304794	CCL2/JUNB/MMP9/TNFAIP3/CEBPB/CREB5/SELE/CREB1/MAPK3/DAB2IP	-0.3274547062875
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/869	49/9376	0.880768417838942	ST6GAL2/LFNG/GXYLT2/B4GALT3	-0.267439572015471
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/869	61/9376	0.88437812446943	FTH1/MT1X/HMOX2/SLC39A4/MT1A	-0.289548158899352
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/869	37/9376	0.874817279880571	APOA1/LAMA4/SELE	-0.24383855080423
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	9/869	108/9376	0.899117759877254	RBM8A/NXT1/DDX39B/ALYREF/SAP18/KPNA1/AAAS/MAGOHB/THOC6	-0.337008529316448
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/869	73/9376	0.886801078235099	BST2/PIN1/SMARCB1/SUPT4H1/MX1/MDFIC	-0.310312678334521
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/869	12/9376	0.899117759877254	COQ2	-0.111758856078591
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/869	12/9376	0.899117759877254	NCAM2	-0.111758856078591
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/869	155/9376	0.904918519618397	WNT4/WNT5A/CDKN2C/WNT6/RASD1/NR4A1/CREB5/LEF1/CREB1/MAPK3/CACNA1H/FZD3/CDKN1B	-0.381487298647024
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/869	86/9376	0.878208044531271	AREG/EIF4EBP1/MYC/HRAS/RPS6KB2/MAPK3/CDKN1B	-0.362632966010528
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/869	38/9376	0.851795772515293	IGF1/SGK1/MAPK3	-0.292572003343399
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/869	26/9376	0.829954855271311	APOA1/SLC19A1	-0.277493244419854
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/869	39/9376	0.829954855271311	MTHFD2/AHCY/DHFR	-0.340094939824946
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	16/869	193/9376	0.894459118634366	CCL2/CCL3/CCL8/RASGRP2/CXCL14/CCL21/CCL23/CCL14/GNG10/CXCL13/GRK5/GNB2/GNG5/GNB5/HRAS/MAPK3	-0.473493900666376
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/869	76/9376	0.851795772515293	CALM2/IGF1/PDGFRA/HRAS/MAPK3/BAX	-0.414603748053947
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/869	100/9376	0.863153049482163	MME/ITGA1/CD55/ITGA6/ITGA3/CD38/IL1R2/CD34	-0.439705668222545
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/869	27/9376	0.799215786557559	ACAT2/ACADS	-0.333915190018599
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/869	27/9376	0.799215786557559	TECR/HACD1	-0.333915190018599
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/869	89/9376	0.848605526176284	GABARAPL2/GABARAP/GNG10/GLUL/GNB2/GNG5/GNB5	-0.4586428352182
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/869	77/9376	0.840733489755354	TGFBR1/MYC/HRAS/MAPK3/BAX/CDKN1B	-0.448496453202905
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/869	160/9376	0.876639815880322	CLDN10/CLDN4/CDH3/NECTIN2/HLA-F/OCLN/SELE/ITGA6/NFASC/CNTNAP2/NTNG2/NCAM2/CD34	-0.503003581356072
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/869	125/9376	0.863153049482163	CTSD/DEGS1/CERS4/SPHK1/SPTSSA/HRAS/MAPK3/ORMDL2/PPP2R3C/BAX	-0.492269694409228
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/869	138/9376	0.860025683360851	CALM2/SPDYE2/IGF1/PPP1CB/YWHAE/SKP1/RBX1/ANAPC15/ANAPC13/ANAPC10/MAPK3	-0.529427175888307
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/869	28/9376	0.770672365609074	TECR/HACD1	-0.38840370586715
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/869	28/9376	0.770672365609074	B4GALT3/B3GNT2	-0.38840370586715
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/869	54/9376	0.799215786557559	CENPX/RAD51C/RPA3/HES1	-0.472910769541707
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/869	103/9376	0.838012669400159	MME/COL4A6/COL27A1/SLC1A1/SLC3A2/ELN/CPA1/COL26A1	-0.528319744054014
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/869	103/9376	0.838012669400159	ACTN1/LAMA4/COL4A6/RAB5C/HSPB1/RAB5B/ARG1/IL1R2	-0.528319744054014
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/869	115/9376	0.84438885275429	PDE4B/JUND/CREB5/SGK1/GATA3/CREB1/MAPK3/FGFR1/BGLAP	-0.536621405800098
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/869	79/9376	0.819449097609649	CYP3A5/GSTP1/GSTT2B/ADH5/HSD11B1/ADH1C	-0.515049658500822
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/869	42/9376	0.770672365609074	MAOB/ACAT2/MAOA	-0.4760520592235
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/869	68/9376	0.793339199891694	DHRS3/CYP3A5/ADH5/HSD17B6/ADH1C	-0.546627762979536
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/869	200/9376	0.863153049482163	ACTB/CLDN10/RPS3/TUBA1A/CLDN4/WIPF1/CYCS/TUBA1B/ARF6/OCLN/TMBIM6/ARPC1B/TUBB/ARPC3/MAPK3/BAX	-0.625216929852962
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	17/869	212/9376	0.865188787806414	ID1/ACTB/CNR1/CALM2/PDGFD/PFN1/IGF1/RASGRP2/PDGFRA/THBS1/EPHA2/VEGFB/HRAS/NGF/MAPK3/FGFR1/MRAS	-0.634539575943612
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/869	56/9376	0.770672365609074	HSPA1B/HSPA1A/CYCS/C3	-0.550110277134227
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/869	69/9376	0.781841530328047	REN/CALM2/KCNMA1/PRKG2/CREB1	-0.581298332177264
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/869	30/9376	0.719294207901803	DHFR/SLC19A1	-0.492160123788822
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/869	57/9376	0.757151797791371	ACAT2/TECR/HACD1/ACADS	-0.58775316271747
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/869	44/9376	0.735641803535935	GTF2H5/TAF10/TAF9	-0.561744803383575
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/869	16/9376	0.67433831990794	HEXB	-0.416673649091787
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	11/869	144/9376	0.824191279887483	SLC25A5/CYCS/PSMB3/PSMB4/PSMA2/PSMA4/XBP1/PSMA1/PSMA5/PPIF/SLC25A4	-0.679486872097203
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/869	168/9376	0.834895062743164	CHMP1B/FTH1/SLC25A5/CHMP5/TNFAIP3/IFNAR2/HMGB1/GLUL/IRF9/SHARPIN/BAX/PPID/SLC25A4	-0.690143426986706
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	13/869	168/9376	0.834895062743164	PRL/CLCF1/PDGFRA/PRLR/IL10RB/SOCS2/IFNAR2/IL13RA1/PIM1/IRF9/MYC/GHR/HRAS	-0.690143426986706
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/869	120/9376	0.809205983889528	CALM2/YWHAE/ARHGDIA/NFKBIE/HRAS/NGF/MAPK3/MAPK7/BAX	-0.67228126693161
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/869	83/9376	0.77995757483328	POLR3GL/POLR2K/POLR2L/POLR2F/IRF7/POLR3C	-0.643538909808711
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/869	31/9376	0.696091168937229	SMOX/ACADS	-0.541678781921468
NA	NA	hsa04981	Folate transport and metabolism	2/869	31/9376	0.696091168937229	DHFR/SLC19A1	-0.541678781921468
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/869	71/9376	0.759817825248383	PRL/PRLR/SOCS2/HRAS/MAPK3	-0.64926062952315
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/869	71/9376	0.759817825248383	ATP6V0C/ATP6V1G1/ATP6V1F/ATP6AP1/PTPRZ1	-0.64926062952315
NA	NA	hsa04382	Cornified envelope formation	17/869	217/9376	0.84525356228092	CLDN10/S100A11/KRT23/S100A6/CLDN4/S100A1/KRT18/S100A10/COL4A6/DSG2/PKP2/KRT10/OCLN/KRT81/ITGA6/PPP2R3C/KRT17	-0.73711255376859
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/869	109/9376	0.791883531635012	PPP1CB/CREB5/SLC27A5/RPS6KB2/CREB1/NR1H2/G6PC3/PRKAG1	-0.698485548353432
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/869	17/9376	0.634671359913355	GGT5	-0.481837689128485
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/869	122/9376	0.795940312022487	IGFBP3/IGF1/JUNB/SOCS2/CREB5/GHR/HRAS/CREB1/MAPK3	-0.725069598639747
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/869	32/9376	0.67433831990794	GABARAPL2/GABARAP	-0.589769817998349
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/869	32/9376	0.67433831990794	CYCS/BAX	-0.589769817998349
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/869	46/9376	0.703657377295242	FTH1/HMOX2/MMAB	-0.643931282972622
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/869	98/9376	0.770672365609074	CALM2/IMPA2/DGKB/IMPA1/IP6K3/DGKE/ITPK1	-0.729372785708079
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/869	60/9376	0.719294207901803	SPHK1/HRAS/HSPB1/MAPK3	-0.697139305219405
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/869	60/9376	0.719294207901803	IGF1/PRKG2/HRAS/MAPK3	-0.697139305219405
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/869	47/9376	0.688685943735769	SOCS2/ABCC8/MAPK3	-0.683813109663226
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	8/869	112/9376	0.770672365609074	HSPA1B/HSPA1A/LAMA4/CYCS/IL10RB/ITGA6/MAPK3/PPIF	-0.780321259640672
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/869	75/9376	0.719294207901803	CYCS/GSTP1/GSTT2B/MAPK3/BAX	-0.780053686253135
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/869	19/9376	0.567863848343529	HEXB	-0.602610085363327
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/869	19/9376	0.567863848343529	PDHB	-0.602610085363327
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/869	76/9376	0.709829810429411	MYLK/ACTB/CALM2/MYLK3/SLC4A2	-0.811755846721071
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/869	102/9376	0.740449919898915	PLA2G2A/KCNMA1/BST1/SLC4A2/CPA1/CD38/RYR2	-0.842354727101798
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/869	115/9376	0.750567869114925	GNG10/CREB5/GNB2/GNG5/GNB5/HRAS/CREB1/MAPK3	-0.860160875980905
Human Diseases	Substance dependence	hsa05034	Alcoholism	14/869	191/9376	0.790847034865856	MAOB/CALM2/PPP1CB/HAT1/GNG10/CREB5/SLC29A1/GNB2/MAOA/GNG5/GNB5/HRAS/CREB1/MAPK3	-0.933358397519931
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/869	91/9376	0.711389875946838	PDE4B/GNG10/GRK5/GNB2/GNG5/GNB5	-0.884196137947251
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	16/869	216/9376	0.799215786557559	HSPA1B/APOA1/HSPA1A/CCL2/CCL3/CALM2/MMP9/HSPA2/CYCS/HSPA5/XBP1/IRF7/SELE/HRAS/MAPK3/BAX	-0.954148588995997
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/869	65/9376	0.663963884217049	NR4A1/CREB5/CREB1/CACNA1H	-0.86886395561158
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	15/869	205/9376	0.789469252575149	ISG15/B2M/CYCS/TNFAIP3/IFNAR2/TAPBPL/NFKBIE/HLA-F/IRF9/IRF7/MYC/ENTPD3/HES1/BAX/CDKN1B	-0.974072822072475
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	15/869	205/9376	0.789469252575149	ACTN1/LTBR/RANBP1/YWHAE/C3/MRPS18B/CREB5/HLA-F/IRF9/IRF7/HRAS/CREB1/MAPK3/BAX/CDKN1B	-0.974072822072475
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/869	37/9376	0.583211519920381	NIT2/GLUL	-0.811846066913661
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/869	21/9376	0.513781577072716	B3GAT3	-0.712896482400926
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/869	21/9376	0.513781577072716	BCAT2	-0.712896482400926
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/869	52/9376	0.622466141453483	IGF1/HSD17B1/HSD17B7	-0.872496625945506
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/869	38/9376	0.567863848343529	GMPPB/HEXB	-0.853085919025398
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/869	67/9376	0.644144066777734	CALM2/PPP1CB/HRAS/MAPK3	-0.934259252224361
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/869	23/9376	0.469104918196828	B4GALT3	-0.814712656182506
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/869	23/9376	0.469104918196828	CA4	-0.814712656182506
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/869	70/9376	0.61653789248726	NFKBIE/G6PC3/ADIPOR1/PRKAG1	-1.02919403569752
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/869	70/9376	0.61653789248726	CYP3A5/GSTP1/GSTT2B/HSD11B1	-1.02919403569752
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/869	70/9376	0.61653789248726	ELOB/RBX1/HRAS/MAPK3	-1.02919403569752
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	11/869	163/9376	0.728119903704279	TGFBR1/MMP9/CYCS/CREB5/IRF7/MYC/ATP6AP1/HRAS/CREB1/MAPK3/BAX	-1.11912343895788
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/869	201/9376	0.75150141124069	IGFBP3/CDKN2C/NUPR1/IGF1/MMP9/MITF/CEBPB/ID2/MYC/RARA/BAX/ERG/IL1R2/CDKN1B	-1.13822004324878
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/869	41/9376	0.5263128350501	MAOB/MAOA	-0.971479620436235
Organismal Systems	Immune system	hsa04611	Platelet activation	8/869	126/9376	0.685042102763622	MYLK/ACTB/MYL12A/PPP1CB/RASGRP2/MYLK3/PRKG2/MAPK3	-1.13755975363313
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/869	254/9376	0.764604079265696	MYLK/CALM2/PDGFD/AVPR1A/SLC25A5/PDGFRA/HTR2A/MYLK3/SPHK1/VEGFB/NGF/FGFR1/CD38/CACNA1H/PTGER3/PPIF/RYR2/SLC25A4	-1.21556466422476
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/869	154/9376	0.700611241462795	TPM1/CALM2/TPM2/PPP1CB/CREM/CREB5/CREB1/MAPK3/PPP2R3C/RYR2	-1.1972658658341
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/869	26/9376	0.414977427635656	PLA2G2A	-0.9546865447011
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/869	26/9376	0.414977427635656	HES1	-0.9546865447011
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/869	59/9376	0.548614226365782	PLIN1/PRKG2/PTGER3	-1.11158617146415
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/869	103/9376	0.628509502050119	CCL2/CCL3/TGFBR1/C3/SERPINE1/MAPK3	-1.21161182216291
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/869	183/9376	0.707502499575544	NOP10/NXT1/SNU13/CSNK2B/NHP2/EIF6/RRP7A/MDN1/FBLL1/AK6/SBDS/RPP25	-1.27710434933577
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/869	90/9376	0.599411839918169	CSNK2B/NFKBIE/HRAS/RPS6KB2/MAPK3	-1.22042848072104
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/869	45/9376	0.479529471934535	ABCC9/ABCC8	-1.11852479182874
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/869	105/9376	0.61653789248726	CALM2/PLK3/IRF9/HRAS/MAPK3/MRAS	-1.26287720373119
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/869	91/9376	0.592824896622365	CD81/NFKBIE/HRAS/MAPK3/LILRB3	-1.24743598325214
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/869	77/9376	0.560488993170236	TGFBR1/RPS6KB2/MAPK3/BAX	-1.23766840501494
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/869	78/9376	0.553303236847541	IMPA2/IMPA1/IP6K3/ITPK1	-1.26611351879967
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/869	63/9376	0.513781577072716	ACAT2/SMYD2/SETMAR	-1.23755410082751
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/869	63/9376	0.513781577072716	PLA2G2A/GGT5/GPX4	-1.23755410082751
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/869	29/9376	0.37204872822507	CALM2	-1.08242080701507
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	6/869	109/9376	0.593912648726259	CCL3/IFNAR2/IRF9/IRF7/CTSK/MAPK3	-1.36292023626108
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/869	30/9376	0.359647103950901	DPM2	-1.12272767238734
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/869	30/9376	0.359647103950901	PLA2G2A	-1.12272767238734
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/869	65/9376	0.497972913162787	HRAS/MAPK3/CACNA1H	-1.2980546435529
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/869	110/9376	0.588513442828748	SPDYE2/IGF1/ANAPC15/ANAPC13/ANAPC10/MAPK3	-1.3874366309426
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/869	31/9376	0.348045584468614	HSD17B14	-1.16202570500632
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/869	83/9376	0.51997171655552	SLC25A17/PEX6/PEX11B/PEX3	-1.40389689838744
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/869	98/9376	0.550480261149339	CALM2/NR4A1/CREB5/CREB1/CACNA1H	-1.42969016807356
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/869	99/9376	0.544919854471063	CALM2/IGF1/PPP1CB/HTR2A/NGF	-1.45481917751959
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/869	72/9376	0.449558879938627	ISG15/PIN1/IRF7	-1.49847526065624
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/869	36/9376	0.299705919959085	AKR1B1	-1.34544384831416
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/869	36/9376	0.299705919959085	G6PC3	-1.34544384831416
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/869	36/9376	0.299705919959085	ST6GALNAC3	-1.34544384831416
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/869	73/9376	0.44340053911755	HRAS/MAPK3/BAX	-1.52580843327024
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/869	37/9376	0.29160575996019	GMPPB	-1.37985358302309
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/869	75/9376	0.431576524741082	HSPA5/CREB5/CREB1	-1.57959272558731
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/869	138/9376	0.547289071229633	ACTB/CCL2/WIPF1/ARF6/ARPC1B/ARPC3/MAPK3	-1.71229604307019
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/869	39/9376	0.27665161842377	HLA-F	-1.44671654516893
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/869	93/9376	0.464060779291486	NFKBIE/GATA3/MAPK3/NOTCH1	-1.66004610304131
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/869	93/9376	0.464060779291486	CALM2/HRAS/MAPK3/MAPK7	-1.66004610304131
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/869	109/9376	0.494927207271883	TGFBR1/NFKBIE/GATA3/MAPK3/RARA	-1.69513758021491
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/869	78/9376	0.414977427635656	MARCKSL1/C3/MAPK3	-1.65818301983229
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/869	83/9376	0.38997878741664	SKP1/CSNK2B/CBX3	-1.7840758926768
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/869	44/9376	0.245213934511978	HLA-F	-1.60387366696181
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/869	45/9376	0.239764735967268	HLA-F	-1.63379470035261
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/869	69/9376	0.312736612131219	HRAS/MAPK3	-1.83126083408706
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/869	105/9376	0.411025261658173	LTBR/CSNK2B/CCL21/TNFAIP3	-1.93970344410295
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/869	48/9376	0.224779439969313	G6PC3	-1.72091310712
NA	NA	hsa04082	Neuroactive ligand signaling	10/869	199/9376	0.542181563745078	GRM7/ADRA2C/GNG10/HTR2A/SLC1A1/GNB2/GNG5/GLRB/GNB5/PENK	-2.08630000940096
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/869	50/9376	0.215788262370541	LTBR	-1.77696119933262
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/869	144/9376	0.449558879938627	C3/ADH5/LEF1/ADIPOR1/PRKAG1/ADH1C	-2.12741162500252
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/869	53/9376	0.203573832425039	CLTB	-1.85828757709992
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/869	54/9376	0.19980394663939	HLA-F	-1.88471655660062
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/869	195/9376	0.497972913162787	ACTB/CAMP/SLC25A5/C3/HAT1/HMGB1/MAPK3/PPIF/SLC25A4	-2.26415821957652
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	21/869	370/9376	0.6123720959164	PRL/GAL/CNR1/GRM7/AVPR1A/ADRA2C/VIPR2/C3/PRLR/TMEM97/PGRMC2/PGRMC1/HTR2A/ADM/F2RL2/GHR/GLRB/TSPO/PENK/PTGER3/LYNX1	-2.43140459830647
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/869	122/9376	0.353751249787772	NFKBIE/HRAS/MAPK3/PPP2R3C	-2.29626599247498
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/869	143/9376	0.377252206941505	ACTN1/C1R/SNRPD3/SNRPD1/C3	-2.39836958543741
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/869	226/9376	0.477407660111816	MYL9/CALM2/PDE4B/PPP1CB/VIPR2/CREB5/CREB1/MAPK3/PTGER3/RYR2	-2.54163991459973
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/869	66/9376	0.163475956341319	GATA3	-2.17963044467571
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/869	90/9376	0.239764735967268	SLC27A5/SLC4A2	-2.31612628811719
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/869	217/9376	0.447487180031076	CREB5/EIF4EBP1/MYC/GSTT2B/HRAS/RPS6KB2/CREB1/KPNA1/MAPK3	-2.63181590297096
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/869	133/9376	0.324493627624873	KLRC3/IFNAR2/HRAS/MAPK3	-2.50758754620205
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/869	323/9376	0.467652580988788	TPM1/STMN1/MMP9/PDGFRA/THBS1/FSCN1/PIM1/MYC/HRAS/MAPK3/MAPK7/FZD3/NOTCH1/CDKN1B	-3.11176981572576
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/869	449/9376	0.072089619945615	CALM2/RGS2/PRKG2	-6.43996854487928