category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	45/345	138/9376	8.86200378071834	NDUFA4/UQCR11/COX8A/ATP6V0E1/MT-ATP6/UQCR10/NDUFC1/NDUFB2/COX6C/ATP5MG/ATP6V0C/ATP6V1F/MT-ND4/COX7B/ATP5PF/ATP5F1E/UQCRQ/NDUFC2/ATP5MF/COX17/COX7C/COX6B1/NDUFB3/COX5B/COX7A2/ATP6V1E1/MT-ND2/ATP6V1G1/ATP6V0B/COX7A2L/COX7A1/NDUFA7/ATP5MC2/COX6A1/ATP5PD/COX5A/NDUFA1/NDUFS8/PPA1/NDUFB8/NDUFA13/NDUFB4/MT-ND3/NDUFA8/NDUFB11	18.1849066991613
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	48/345	235/9376	5.55100832562442	NDUFA4/UQCR11/RHEB/PLIN1/COX8A/MT-ATP6/UQCR10/NDUFC1/NDUFB2/COX6C/NDUFAF3/ATP5MG/MT-ND4/ACTB/CNR1/COX7B/ATP5PF/ATP5F1E/UQCRQ/NDUFC2/ATP5MF/COX17/COX7C/COX6B1/NDUFB3/COX5B/COX7A2/MT-ND2/GNAS/COX16/COX7A2L/COX7A1/NDUFA7/ATP5MC2/COX6A1/ATP5PD/COX5A/NDUFA1/NDUFS8/COX20/NDUFB8/COX14/NDUFA13/NDUFB4/MT-ND3/NDUFA8/MAP3K5/NDUFB11	13.8093097530132
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	51/345	268/9376	5.17170668397145	CALM2/MAOA/NDUFA4/MAOB/UQCR11/COX8A/MT-ATP6/UQCR10/NDUFC1/NDUFB2/COX6C/CALM3/MT-ND4/TXN/COX7B/ATP5PF/ATP5F1E/UQCRQ/NDUFC2/COX7C/COX6B1/NDUFB3/PARK7/COX5B/COX7A2/UCHL1/MT-ND2/GNAS/COX7A2L/COX7A1/NDUFA7/UBA52/ATP5MC2/COX6A1/ATP5PD/COX5A/PSMA7/NDUFA1/NDUFS8/NDUFB8/NDUFA13/NDUFB4/PSMA5/MT-ND3/PSMA2/PSMB4/PSMA6/NDUFA8/MAP3K5/GNAI2/NDUFB11	13.5424398678431
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	41/345	205/9376	5.43536231884058	MMP9/NDUFA4/TGFBR1/REN/UQCR11/COX8A/CTSD/MT-ATP6/UQCR10/NDUFC1/NDUFB2/COX6C/MT-ND4/COX7B/ATP5PF/ATP5F1E/UQCRQ/NDUFC2/COX7C/COX6B1/NDUFB3/COX5B/COX7A2/MT-ND2/COX7A2L/COX7A1/NDUFA7/ATP5MC2/COX6A1/ATP5PD/COX5A/NDUFA1/NDUFS8/NDUFB8/NDUFA13/NDUFB4/PPP1CB/MT-ND3/TBC1D4/NDUFA8/NDUFB11	12.5494574662905
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	49/345	308/9376	4.3235836627141	NDUFA4/UQCR11/COX8A/MT-ATP6/POLR2L/UQCR10/NDUFC1/NDUFB2/CLTB/COX6C/DCTN6/POLR2J/MT-ND4/POLR2K/COX7B/ATP5PF/ATP5F1E/UQCRQ/NDUFC2/COX7C/COX6B1/POLR2I/NDUFB3/SLC1A2/COX5B/COX7A2/MT-ND2/COX7A2L/COX7A1/AP2S1/NDUFA7/ATP5MC2/COX6A1/ATP5PD/COX5A/PSMA7/NDUFA1/NDUFS8/NDUFB8/NDUFA13/NDUFB4/PSMA5/MT-ND3/PSMA2/PSMB4/PSMA6/NDUFA8/MAP3K5/NDUFB11	11.5918694831812
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	45/345	275/9376	4.44711462450593	NDUFA4/IL1B/UQCR11/COX8A/MT-ATP6/UQCR10/NDUFC1/NDUFB2/COX6C/MT-ND4/COX7B/ATP5PF/ATP5F1E/UQCRQ/CSNK2B/NDUFC2/COX7C/COX6B1/NDUFB3/COX5B/COX7A2/MT-ND2/COX7A2L/COX7A1/NDUFA7/ATP5MC2/COX6A1/ATP5PD/COX5A/PSMA7/NDUFA1/NDUFS8/NDUFB8/C1QB/HSPA1B/NDUFA13/NDUFB4/PSMA5/MT-ND3/PSMA2/PSMB4/PSMA6/NDUFA8/HSPA1A/NDUFB11	11.3397839234266
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	48/345	368/9376	3.54480151228733	NDUFA4/UQCR11/COX8A/MT-ATP6/UQCR10/NDUFC1/NDUFB2/COX6C/DCTN6/MT-ND4/ACTB/COX7B/ATP5PF/ATP5F1E/PFN1/UQCRQ/NDUFC2/COX7C/COX6B1/NDUFB3/SLC1A2/COX5B/COX7A2/MT-ND2/COX7A2L/COX7A1/NDUFA7/ATP5MC2/DERL1/ANXA11/COX6A1/ATP5PD/COX5A/PSMA7/NDUFA1/ANG/NDUFS8/NDUFB8/NDUFA13/NDUFB4/PSMA5/MT-ND3/PSMA2/PSMB4/PSMA6/NDUFA8/MAP3K5/NDUFB11	9.7339900811697
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	37/345	227/9376	4.42970056821809	NDUFA4/UQCR11/COX8A/MT-ATP6/UQCR10/MGST1/NDUFC1/NDUFB2/COX6C/MT-ND4/COX7B/ATP5PF/ATP5F1E/UQCRQ/NDUFC2/COX7C/COX6B1/NDUFB3/COX5B/COX7A2/MT-ND2/COX7A2L/COX7A1/NDUFA7/ATP5MC2/COX6A1/ATP5PD/COX5A/NDUFA1/NDUFS8/NDUFB8/NDUFA13/NDUFB4/MT-ND3/NDUFA8/MAP3K5/NDUFB11	10.2237350182815
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	49/345	388/9376	3.43212311370088	CALM2/DKK1/WNT4/NDUFA4/IL1B/UQCR11/COX8A/MT-ATP6/WNT6/UQCR10/NDUFC1/NDUFB2/COX6C/CALM3/MT-ND4/COX7B/ATP5PF/ATP5F1E/UQCRQ/CSNK2B/NDUFC2/COX7C/COX6B1/NDUFB3/COX5B/COX7A2/MT-ND2/MME/COX7A2L/COX7A1/NDUFA7/ATP5MC2/COX6A1/ATP5PD/COX5A/PSMA7/NDUFA1/NDUFS8/NDUFB8/NDUFA13/NDUFB4/PSMA5/MT-ND3/PSMA2/PSMB4/PSMA6/NDUFA8/MAP3K5/NDUFB11	9.56306594508561
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	53/345	480/9376	3.0007729468599	CALM2/DKK1/WNT4/NDUFA4/IL1B/UQCR11/COX8A/MT-ATP6/WNT6/UQCR10/NDUFC1/NDUFB2/COX6C/DCTN6/CALM3/MT-ND4/COX7B/ATP5PF/ATP5F1E/UQCRQ/CSNK2B/NDUFC2/COX7C/COX6B1/NDUFB3/PARK7/COX5B/COX7A2/UCHL1/MT-ND2/COX7A2L/COX7A1/NDUFA7/UBA52/ATP5MC2/DERL1/COX6A1/ATP5PD/COX5A/PSMA7/NDUFA1/NDUFS8/NDUFB8/NDUFA13/NDUFB4/PSMA5/MT-ND3/PSMA2/PSMB4/PSMA6/NDUFA8/MAP3K5/NDUFB11	8.79525231153715
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	29/345	157/9376	5.01992061294194	NDUFA4/IL1B/UQCR11/COX8A/UQCR10/NDUFC1/NDUFB2/COX6C/COX7B/UQCRQ/NDUFC2/COX7C/COX6B1/NDUFB3/COX5B/COX7A2/COX7A2L/COX7A1/NDUFA7/COX6A1/COX5A/NDUFA1/NDUFS8/NDUFB8/NDUFA13/NDUFB4/NDUFA8/MAP3K5/NDUFB11	9.9277917782056
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/345	87/9376	4.68565717141429	UQCR11/COX8A/UQCR10/COX6C/COX7B/UQCRQ/COX7C/COX6B1/COX5B/COX7A2/COX7A2L/COX7A1/TPM3/COX6A1/COX5A	6.75021095553142
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	26/345	250/9376	2.8263884057971	NPC2/CTSL/CTSB/CTSD/LAMTOR5/ATP6V0E1/CD68/CLTB/ATP6V0C/ATP6V1F/DEPTOR/BORCS7/ATP6V1E1/KXD1/ATP6V1G1/ATP6V0B/VPS29/BLOC1S1/AP2S1/ASAH1/GPR155/CTSZ/CD63/LAMTOR1/CTSK/SNAPIN	5.7207132352305
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	19/345	149/9376	3.46549946503258	NDUFA4/NDUFC1/NDUFB2/MT-ND4/CNR1/NDUFC2/GNG5/NDUFB3/MT-ND2/NDUFA7/NDUFA1/NDUFS8/NDUFB8/NDUFA13/NDUFB4/MT-ND3/NDUFA8/GNAI2/NDUFB11	5.92918568121382
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/345	95/9376	4.00500381388253	CCL3/IL1B/CTSL/ATP6V0E1/ATP6V0C/ATP6V1F/HLA-DPA1/CCL2/ATP6V1E1/ATP6V1G1/ATP6V0B/HLA-DMA/CTSK/TNFSF13B	5.75356082169783
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/345	51/9376	4.79590792838875	SEC61G/ATP6V0E1/ATP6V0C/ATP6V1F/ACTB/ATP6V1E1/GNAS/ATP6V1G1/ATP6V0B	5.31255699395255
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/345	79/9376	3.78411300678775	ATP6V0E1/CLTB/ATP6V0C/ATP6V1F/SLC1A2/ATP6V1E1/ATP6V1G1/ATP6V0B/AP2S1/VAMP2/SLC1A1	4.85686748156694
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/345	78/9376	3.4842066146414	CALM2/IL1B/SERPING1/CFL2/CALM3/CFL1/LY96/RHOA/C1QB/GNAI2	4.30593538850729
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	14/345	142/9376	2.67940395999183	CALM2/MMP9/IL1B/CTSL/KLF2/MGST1/CALM3/TXN/ACTB/CCL2/MAPK7/IL1R2/RHOA/MAP3K5	3.94122904420991
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/345	82/9376	3.31424531636621	B2M/CTSL/CTSB/HLA-DPA1/CD74/IFI30/HLA-DMA/KLRC3/HSPA1B/HSPA1A	4.1137912507665
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	16/345	184/9376	2.36320100819156	SEMA3B/WNT4/SEMA3A/MYL12A/CFL2/CFL1/DPYSL2/SEMA3C/MYL12B/RRAS/ABLIM3/RHOA/SEMA7A/UNC5B/MYL9/GNAI2	3.64998489240811
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/345	63/9376	3.45102369450195	POLE4/POLR2L/POLR2J/GTF2H5/POLR2K/POLD4/RBX1/POLR2I	3.81505011717087
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/345	28/9376	4.85300207039337	ATP6V0E1/ATP6V0C/ATP6V1F/ATP6V1E1/ATP6V1G1	3.99067325819651
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	18/345	248/9376	1.97251051893408	IL1B/DYNLRB1/MYL12A/DCTN6/TXN/ACTB/SKP1/PFN1/DYNLT3/ANXA2/MYL12B/ARPC3/LY96/RRAS/ARPC1B/RHOA/MYL9/DYNLT1	3.03360894876669
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/345	88/9376	2.77944664031621	CFH/CD59/CLU/SERPING1/TFPI/SERPINE1/SERPINB2/F3/C1QB	3.27787559499439
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/345	34/9376	3.99658994032396	POLR2L/POLR2J/POLR2K/POLR2I/POLR3GL	3.42116569735088
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/345	116/9376	2.34282858570715	THY1/MMP9/MYL12A/RAP1B/CLDN4/ACTB/MYL12B/RHOA/MYL9/GNAI2	2.84427342572835
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/345	250/9376	1.8480231884058	RAB11FIP1/TGFBR1/RAB31/CLTB/SMAP2/CHMP5/ARPC3/VPS37A/VPS29/AP2S1/ARPC1B/RHOA/WIPF1/CAPZA2/HSPA1B/SNX3/HSPA1A	2.65622441661205
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	16/345	232/9376	1.87426286856572	RGCC/MYL12A/CFL2/ITGA1/CFL1/ACTB/PFN1/MYL12B/ARPC3/PDGFC/RRAS/ARPC1B/RHOA/PDGFD/PPP1CB/MYL9	2.63539174904574
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/345	158/9376	2.06406164006604	WNT4/CAB39L/RHEB/SGK1/LAMTOR5/WNT6/ATP6V1F/DEPTOR/ATP6V1E1/ATP6V1G1/RHOA/LAMTOR1	2.63635714334828
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/345	42/9376	3.23533471359558	FTH1/SAT1/GPX4/SLC40A1/FTL	2.83766140936404
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/345	93/9376	2.33779024466262	TGFBR1/MYL12A/RAP1B/ACTB/CSNK2B/MYL12B/RHOA/MYL9	2.53403487919998
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/345	212/9376	1.79469510527755	RASGRP2/CALM2/RAP1B/CALM3/ACTB/CNR1/PFN1/PDGFC/RRAS/GNAS/RHOA/SIPA1L2/PDGFD/GNAI2	2.28745833797851
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/345	31/9376	3.50668536699392	SEC11C/SRP14/SEC61G/SRP19	2.73223647276054
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/345	46/9376	2.95400126023945	PSMA7/PSMA5/PSMA2/PSMB4/PSMA6	2.59651118679831
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	12/345	174/9376	1.87426286856572	CRYAB/SEC61G/SSR4/SKP1/RBX1/UBE2D1/DERL1/HSPA1B/RPN2/KRTCAP2/HSPA1A/MAP3K5	2.27511213992125
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/345	155/9376	1.92867695184666	CTSL/SEC61G/ATP6V0E1/ATP6V0C/ATP6V1F/ACTB/HLA-DPA1/ATP6V1E1/ATP6V1G1/ATP6V0B/HLA-DMA	2.27860355133234
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/345	49/9376	2.77314404022479	MAOA/MAOB/GNAS/GPSM1/GNAI2	2.43219467273491
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/345	103/9376	2.11082031799634	CCL3/TGFBR1/IL1B/SERPINE1/CCL2/GNAS/C1QB/GNAI2	2.21553982943922
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/345	50/9376	2.71768115942029	SAT1/MAOA/MAOB/ARG1/SMOX	2.38016526642667
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/345	69/9376	2.36320100819156	CALM2/REN/CTSB/CALM3/GNAS/GNAI2	2.22129813322849
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/345	69/9376	2.36320100819156	CALM2/MAOA/MAOB/CALM3/GNAS/PPP1CB	2.22129813322849
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/345	52/9376	2.61315496098105	APOA1/NPC2/APOC1/TSPO/APOC3	2.27983749566513
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/345	36/9376	3.01964573268921	POLE4/RNASEH2C/POLD4/SSBP1	2.37290457207506
Organismal Systems	Immune system	hsa04611	Platelet activation	9/345	126/9376	1.94120082815735	RASGRP2/MYL12A/RAP1B/ACTB/MYL12B/GNAS/RHOA/PPP1CB/GNAI2	2.07885391364082
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/345	89/9376	2.1375020354991	GJA1/HTR2B/PDGFC/GNAS/MAPK7/PDGFD/GNAI2	2.10735027204868
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/345	71/9376	2.29663196570729	ATP6V0E1/ATP6V0C/ATP6V1F/ATP6V1E1/ATP6V1G1/ATP6V0B	2.1434579806847
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	15/345	253/9376	1.61127341467606	IL1B/MYL12A/ACTB/SKP1/PFN1/RBX1/UBE2D1/MYL12B/ARPC3/CAST/UBA52/ARPC1B/RHOA/SEPTIN7/MYL9	1.92643427126913
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	13/345	216/9376	1.63564143853999	APOA1/CALM2/MMP9/CCL3/IL1B/RAP1B/CALM3/CCL2/LY96/RHOA/HSPA1B/HSPA1A/MAP3K5	1.84721992817309
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/345	133/9376	1.83903236351749	CALM2/MAOA/MAOB/CALM3/COMT/GNG5/GNAS/PPP1CB/GNAI2	1.90469447273081
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/345	134/9376	1.82530824140169	CALM2/CALD1/ADM/CALM3/KCNMB4/GNAS/RHOA/PPP1CB/MYL9	1.88067115520543
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/345	59/9376	2.30311962662736	CDA/UPP1/NME1/NUDT2/CMPK1	1.96245410336847
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/345	181/9376	1.65162943390183	CALM2/IL1B/CTSD/CALM3/ATP6V0C/HLA-DPA1/CD74/CAMP/ATP6V0B/HLA-DMA/RHOA	1.7301803616816
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/345	139/9376	1.75964967156709	CALM2/MMP9/KRT23/CTSD/CALM3/GNAS/HSPA1B/HSPA1A/GNAI2	1.76352876282175
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	12/345	203/9376	1.60651103019919	MYL12A/RAP1B/ITGA1/ACTB/MYL12B/COL4A6/PDGFC/EMP2/RHOA/PDGFD/PPP1CB/MYL9	1.70749047728672
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/345	140/9376	1.74708074534161	CALM2/TGFBR1/PLIN1/KLF2/SERPINE1/CALM3/GNG5/RRAS/GNAI2	1.74067168049726
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	12/345	204/9376	1.59863597612958	DCN/LUM/TIMP3/MMP9/WNT4/CTSL/WNT6/ACTB/RRAS/RHOA/CD63/PPP1CB	1.6895581293481
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/345	100/9376	1.9023768115942	CD59/IL1B/ITGA1/HLA-DPA1/MME/HLA-DMA/IL1R2	1.7731064977052
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/345	142/9376	1.72247397428047	SKP1/RBX1/UBE2D1/ELOB/UBE2M/UBA52/ELOC/ANAPC11/UBE2B	1.69550357088224
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/345	85/9376	1.9183631713555	CDA/NUDT16/UPP1/NME1/DGUOK/CMPK1	1.66234038786098
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	12/345	214/9376	1.52393336042259	B2M/CALM2/CFL2/CALM3/CFL1/SKP1/RBX1/BST2/ELOB/GNG5/ELOC/GNAI2	1.51535734976948
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/345	15/9376	3.62357487922705	ST6GALNAC3/ST3GAL5	1.98749129595198
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/345	154/9376	1.58825522303783	CALM2/CALM3/ACTB/GNAS/MAPK7/RHOA/PPP1CB/MYL9/GNAI2	1.43860265667977
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/345	16/9376	3.39710144927536	MAOA/MAOB	1.87558066069938
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/345	178/9376	1.52678716821365	DKK1/LGR4/WNT4/NKD1/WNT6/SKP1/RBX1/CSNK2B/DAAM1/RHOA	1.38683805664755
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/345	157/9376	1.55790639711991	WNT4/TGFBR1/NKD1/WNT6/SERPINE1/ACTB/YWHAH/AREG/PPP1CB	1.37783281702219
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/345	73/9376	1.86142545165773	MX1/BST2/MDFIC/PIN1/SUPT4H1	1.44409207104894
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/345	115/9376	1.65424070573409	MAOA/MAOB/KCND2/GNG5/HTR2B/GNAS/GNAI2	1.37970044497553
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	12/345	227/9376	1.43665964374641	B2M/CALM2/CCL3/IL1B/RHEB/CCL4/CALM3/GNG5/CCL2/GNAS/RHOA/GNAI2	1.30165663212982
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/345	116/9376	1.639980009995	GLUL/HOMER2/GNG5/SLC1A2/GNAS/SLC1A1/GNAI2	1.35555509824627
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/345	138/9376	1.57546733879437	CALM2/CPEB4/CALM3/SKP1/RBX1/YWHAH/ANAPC11/PPP1CB	1.33106268532399
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/345	76/9376	1.78794813119756	CALM2/CALM3/ACTB/GNAS/GNAI2	1.34800100594255
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/345	233/9376	1.39966411643963	DCN/FBN2/NID2/PDLIM1/ITGA1/ACTB/COL4A6/SGCE/TPM3/DAAM1/CAPZA2/MYL9	1.20741348625272
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/345	37/9376	2.20352526439483	MAOA/MAOB/COMT	1.43361702667211
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/345	99/9376	1.64707949055775	CALM2/IL1B/CALM3/HTR2B/GNAS/PPP1CB	1.26502386452061
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/345	99/9376	1.64707949055775	CFH/KRT23/HLA-DPA1/CAMP/HLA-DMA/C1QB	1.26502386452061
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/345	78/9376	1.7421033073207	CLTB/ACTB/ARPC3/ARPC1B/RHOA	1.28630560521302
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/345	101/9376	1.61446405510116	CALM2/WNT4/WNT6/CALM3/GNAS/GNAI2	1.21346561605496
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/345	101/9376	1.61446405510116	TGFBR1/IL1B/SERPINE1/F3/COL4A6/CCL2	1.21346561605496
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/345	169/9376	1.44728582454335	CTSL/RHEB/CTSB/CTSD/GABARAP/DEPTOR/GABARAPL2/RRAS/UBA52	1.14682375436495
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/345	193/9376	1.40812495306751	RASGRP2/CCL3/CXCL14/CCL4/CCL8/RAP1B/GNG5/CCL2/RHOA/GNAI2	1.11971314224731
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	9/345	170/9376	1.43877237851662	MYL12A/CLDN4/ACTB/MYL12B/ARPC3/ARPC1B/RHOA/MYL9/MAP3K5	1.128380364503
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/345	194/9376	1.40086657702077	DYNLRB1/MYL12A/DCTN6/ACTB/DYNLT3/MYL12B/TPM3/CAPZA2/MYL9/DYNLT1	1.10270497261387
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/345	103/9376	1.58311523849726	CPB1/COL14A1/COL4A6/MME/SLC7A8/SLC1A1	1.16302791289768
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/345	82/9376	1.6571226581831	CDA/MGST1/UPP1/NME1/CMPK1	1.16809805027874
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/345	61/9376	1.78208600617724	FTH1/SLC40A1/FTL/ATOX1	1.19771990623462
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/345	105/9376	1.55296066252588	CITED2/GABARAP/GABARAPL2/CSNK2B/RRAS/UBA52	1.11366061358788
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/345	83/9376	1.63715732495198	IL1B/CCL4/POLR2L/POLR2K/POLR3GL	1.13955429535562
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/345	22/9376	2.47061923583663	MAOA/MAOB	1.34970906430714
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/345	23/9376	2.36320100819156	GLUL/ARG1	1.27930946798826
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/345	23/9376	2.36320100819156	POLD4/SSBP1	1.27930946798826
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/345	23/9376	2.36320100819156	REN/MME	1.27930946798826
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/345	133/9376	1.43035850495805	DEPP1/TGFBR1/KLF2/SGK1/GABARAP/GABARAPL2/HOMER2	0.976960486064973
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/345	180/9376	1.35884057971015	B2M/IL1B/RHEB/BST2/HLA-DPA1/CD74/CCL2/HLA-DMA/PPP1CB	0.95009183421226
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/345	44/9376	1.85296442687747	RPN2/KRTCAP2/B4GALT3	1.10840163299349
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/345	44/9376	1.85296442687747	GTF2H5/GTF2A2/TAF10	1.10840163299349
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/345	44/9376	1.85296442687747	POLE4/POLD4/UNG	1.10840163299349
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/345	44/9376	1.85296442687747	IL1B/HLA-DPA1/HLA-DMA	1.10840163299349
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/345	44/9376	1.85296442687747	DCTN6/GNAS/VAMP2	1.10840163299349
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/345	157/9376	1.38480568632881	CALM2/IGFBP3/TGFBR1/RHEB/SERPINE1/CALM3/RRAS/PPP1CB	0.950334868963022
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/345	45/9376	1.81178743961353	IL1B/HLA-DPA1/HLA-DMA	1.06687061680319
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/345	89/9376	1.52678716821365	GLUL/GABARAP/GABARAPL2/GNG5/GNAI2	0.975932391856941
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/345	112/9376	1.45590062111801	HLA-DPA1/LY96/HLA-DMA/HSPA1B/HSPA1A/GNAI2	0.948652567865025
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/345	67/9376	1.62249621457928	CALM2/RAP1B/CALM3/PPP1CB	0.999424210118569
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/345	46/9376	1.77240075614367	FTH1/FTL/BLVRB	1.02637968809331
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/345	137/9376	1.38859621284248	CTSL/CTSB/CTSD/ACTB/CTSZ/CTSK/MAP3K5	0.89551657463934
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/345	138/9376	1.37853392144507	IL1B/ACTB/ARPC3/CCL2/ARPC1B/RHOA/WIPF1	0.875553387652707
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	9/345	187/9376	1.30797488956057	IL1B/CTSB/GABARAP/TXN/GABARAPL2/TXNIP/CAMP/CCL2/RHOA	0.831436814306786
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/345	70/9376	1.55296066252588	RAP1B/RBX1/ELOB/ELOC	0.907588527142223
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/345	70/9376	1.55296066252588	ACTB/HLA-DPA1/SGCE/HLA-DMA	0.907588527142223
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/345	93/9376	1.46111890291413	CALM2/CALM3/CAMP/GNAS/VAMP2	0.873448874444092
NA	NA	hsa03272	Virion - Hepatitis viruses	3/345	48/9376	1.69855072463768	CD81/CLDN4/CD63	0.948312689780458
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/345	28/9376	1.94120082815735	PCBD1/MOCS2	0.974830770110765
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/345	50/9376	1.63060869565217	HLA-DPA1/HLA-DMA/TNFSF13B	0.873825101862615
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/345	50/9376	1.63060869565217	IL1B/CD81/CCL2	0.873825101862615
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/345	120/9376	1.35884057971015	CALM2/RAP1B/CALM3/MAPK7/RHOA/MAP3K5	0.773228341880078
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/345	73/9376	1.48914036132619	MAOA/MAOB/MGST1/CYP3A5	0.819994018126381
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/345	97/9376	1.40086657702077	CALM2/CALM3/GNG5/GNAS/GNAI2	0.775643919068591
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/345	29/9376	1.87426286856572	CALM2/CALM3	0.921578163549486
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/345	98/9376	1.38657202011239	PLPP3/CFL2/CFL1/ARPC3/ARPC1B	0.751871347895273
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/345	75/9376	1.44942995169082	IGFBP3/CD82/SERPINE1/TP53I3	0.763756793340697
Genetic Information Processing	Translation	hsa03010	Ribosome	10/345	222/9376	1.22418070244157	MRPL33/MRPS6/RPL36AL/MRPL54/MRPL50/UBA52/MRPS18A/RPLP1/RPS15/MRPL34	0.660688159089011
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/345	298/9376	1.18556560645852	PRL/IL1RL1/PRLR/CCL3/TGFBR1/IL1B/TNFRSF21/CXCL14/CCL4/CCL8/CCL2/IL1R2/TNFSF13B	0.636264646541701
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/345	76/9376	1.43035850495805	APOA1/PLIN1/FABP5/APOC3	0.736246047969782
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/345	100/9376	1.35884057971015	CCL3/CXCL14/CCL4/CCL8/CCL2	0.705096313811845
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/345	149/9376	1.27676296080148	PLPP3/RHEB/PDGFC/RRAS/GNAS/RHOA/PDGFD	0.665576694518885
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/345	53/9376	1.5383100902379	CLTB/GNAS/AP2S1	0.768103736401222
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/345	125/9376	1.30448695652174	CTSD/ORMDL2/ASAH1/RHOA/MAP3K5/GNAI2	0.669817706546037
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/345	10/9376	2.71768115942029	TST	1.06216684239033
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/345	200/9376	1.22295652173913	IL1B/TMBIM6/CLDN4/ACTB/TMED10/ARPC3/ARPC1B/RHOA/WIPF1	0.622924970749021
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/345	31/9376	1.75334268349696	PGD/RBKS	0.821128324854776
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/345	31/9376	1.75334268349696	HSD17B14/UGDH	0.821128324854776
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/345	31/9376	1.75334268349696	GLUL/MCEE	0.821128324854776
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/345	226/9376	1.20251378735411	CALM2/RAP1B/CALM3/FXYD1/RRAS/GNAS/RHOA/PPP1CB/MYL9/GNAI2	0.602317571268309
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/345	103/9376	1.31926269874771	IL1B/ARG1/COL4A6/GNAS/IL1R2	0.636771954626908
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/345	32/9376	1.69855072463768	GABARAP/GABARAPL2	0.773630861823202
Human Diseases	Immune disease	hsa05310	Asthma	2/345	32/9376	1.69855072463768	HLA-DPA1/HLA-DMA	0.773630861823202
NA	NA	hsa04518	Integrin signaling	7/345	154/9376	1.23530961791831	FERMT2/ITGA1/ACTB/COL4A6/PDGFC/LIMS2/PDGFD	0.575459474429207
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/345	56/9376	1.45590062111801	RPN2/KRTCAP2/B4GALT3	0.668780352405927
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/345	56/9376	1.45590062111801	IL1B/HSPA1B/HSPA1A	0.668780352405927
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	14/345	333/9376	1.14256865561213	ISG15/WNT4/RHEB/MX1/ATP6V0E1/WNT6/ATP6V0C/ATP6V1F/ITGA1/COL4A6/ATP6V1E1/GNAS/ATP6V1G1/ATP6V0B	0.517746498264902
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/345	105/9376	1.29413388543823	IL1B/CCL4/CSNK2B/LY96/TNFSF13B	0.592384495920267
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/345	105/9376	1.29413388543823	CALM2/IL1B/CALM3/RRAS/RHOA	0.592384495920267
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/345	105/9376	1.29413388543823	ITGA1/ACTB/SGCE/GNAS/TPM3	0.592384495920267
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/345	130/9376	1.2543143812709	MMP9/TGFBR1/COL4A6/GNG5/GNAS/GNAI2	0.570680346247844
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/345	34/9376	1.59863597612958	SKP1/RBX1	0.683454495783723
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/345	59/9376	1.38187177597642	GPX4/MGST1/PGD	0.5750859847496
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/345	59/9376	1.38187177597642	PLIN1/GNAS/GNAI2	0.5750859847496
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/345	109/9376	1.24664273367903	CCL3/IL1B/CCL4/LY96/CTSK	0.506219950857426
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/345	238/9376	1.14188284009256	RASGRP2/CALM2/RAP1B/CALM3/ETS2/GNG5/PDGFC/RRAS/RHOA/PDGFD	0.433331279804183
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/345	110/9376	1.23530961791831	DCN/TGFBR1/SKP1/RBX1/RHOA	0.485195917387418
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/345	36/9376	1.50982286634461	ST6GALNAC3/GALNT15	0.598996641300401
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/345	86/9376	1.26403774856758	GJA1/ITGA1/ACTB/SGCE	0.480767004662141
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/345	37/9376	1.46901684292989	NAGK/UGDH	0.558684185294924
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/345	37/9376	1.46901684292989	APOA1/IL1B	0.558684185294924
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/345	37/9376	1.46901684292989	CCDC6/TPM3	0.558684185294924
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/345	62/9376	1.31500701262272	CRYAB/HSPA1B/HSPA1A	0.486379447009423
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/345	191/9376	1.13829577357918	CALM2/MAOA/MAOB/CALM3/GNG5/GNAS/PPP1CB/GNAI2	0.377409889320697
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/345	14/9376	1.94120082815735	B4GALT3	0.688793856152983
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/345	38/9376	1.43035850495805	NAGK/UGDH	0.519544220763173
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/345	166/9376	1.14601012746639	CALM2/CALM3/KCNMB4/RHOA/PPP1CB/MYL9/GNAI2	0.370966312973362
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/345	39/9376	1.39368264585656	HLA-DPA1/HLA-DMA	0.481506505956357
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/345	300/9376	1.08707246376812	RASGRP2/TGFBR1/IL1B/RAP1B/PDGFC/RRAS/AREG/MAPK7/PDGFD/HSPA1B/HSPA1A/MAP3K5	0.299585977367855
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/345	144/9376	1.13236714975845	PSMA7/PSMA5/PSMA2/PSMB4/PSMA6/MAP3K5	0.312853364685451
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/345	66/9376	1.23530961791831	HSD11B1/CYP3A5/COMT	0.374941981768268
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/345	66/9376	1.23530961791831	IL1B/HLA-DPA1/HLA-DMA	0.374941981768268
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/345	41/9376	1.32569812654648	MAOA/MAOB	0.408486108808133
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/345	41/9376	1.32569812654648	POLD4/SSBP1	0.408486108808133
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/345	93/9376	1.16889512233131	CALM2/CALM3/GNAS/MAPK7	0.319920206192128
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/345	94/9376	1.15646006783842	MMP9/IL1B/CCL2/MAPK7	0.297970948615001
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/345	42/9376	1.29413388543823	MAOA/MAOB	0.373390334260868
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/345	17/9376	1.59863597612958	GLUL	0.482836190402182
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/345	17/9376	1.59863597612958	PCDH20	0.482836190402182
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/345	43/9376	1.26403774856758	APOA1/PLPP3	0.339169569656753
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/345	70/9376	1.16472049689441	HSD11B1/MGST1/CYP3A5	0.270359979105269
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/345	98/9376	1.10925761608991	CALM2/IMPA2/CALM3/IP6K3	0.212502888991977
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/345	99/9376	1.09805299370517	PLPP3/RHEB/PDGFC/PDGFD	0.191691096433624
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/345	99/9376	1.09805299370517	ITGA1/ACTB/SGCE/TPM3	0.191691096433624
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/345	154/9376	1.05883681535855	CALM2/CALM3/GNAS/TPM3/PPP1CB/GNAI2	0.143887883303927
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	9/345	238/9376	1.0276945560833	ISG15/IL1B/RPL36AL/MX1/CCL2/UBA52/RPLP1/RPS15/C1QB	0.0845832901523359
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/345	102/9376	1.06575731741972	CPB1/RAP1B/GNAS/RHOA	0.130508227845025
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/345	20/9376	1.35884057971015	UGDH	0.313977628933612
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/345	243/9376	1.00654857756307	SNRPG/RBM8A/LSM3/RP9/BCAS2/ZMAT2/HSPA1B/CWC15/HSPA1A	0.0202148558303898
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/345	49/9376	1.10925761608991	GALNT15/B4GALT3	0.149867007857928
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/345	106/9376	1.0255400601586	MMP9/PDGFC/IL1R2/PDGFD	0.0516847293073838
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/345	78/9376	1.04526198439242	NUDT16/DHX36/LSM3	0.0784536918953161
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/345	78/9376	1.04526198439242	IL1B/HLA-DPA1/HLA-DMA	0.0784536918953161
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/345	107/9376	1.01595557361506	CALM2/CALM3/PHKG1/GNAS	0.0324425613362972
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/345	79/9376	1.03203082003302	HSD11B1/MGST1/CYP3A5	0.0558775623859455
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/345	136/9376	0.999147485080989	IL1B/MX1/CSNK2B/HSPA1B/HSPA1A	-0.0019573239989196
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/345	51/9376	1.06575731741972	PLPP3/PLA2G7	0.092030550569751
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/345	109/9376	0.997314186943226	TGFBR1/IL1B/HLA-DPA1/HLA-DMA	-0.00551247601472784
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/345	138/9376	0.984667086746482	CALM2/RHEB/CALM3/PHKG1/PPP1CB	-0.0354652076898501
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/345	23/9376	1.18160050409578	B4GALT3	0.170424789070082
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/345	110/9376	0.988247694334651	SERPINE1/RBX1/ELOB/ELOC	-0.0242326292446573
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/345	224/9376	0.970600414078675	B2M/TGFBR1/TSPO/ETS2/HLA-DPA1/HLA-DMA/IL1R2/ANAPC11	-0.0870431264247108
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/345	83/9376	0.982294394971189	SKP1/UBE2D1/CSNK2B	-0.0316664306793807
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/345	54/9376	1.00654857756307	TST/CISD1	0.00943227753606217
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/345	54/9376	1.00654857756307	HLA-DPA1/HLA-DMA	0.00943227753606217
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/345	142/9376	0.95692998571137	TGFBR1/IL1B/FOSL2/TYROBP/CTSK	-0.101076807779893
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/345	55/9376	0.988247694334651	PLPP3/ASAH1	-0.017084427645112
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/345	115/9376	0.945280403276623	SGK1/GNAS/RHOA/GNAI2	-0.115395834111872
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	6/345	173/9376	0.942548378989696	IL1B/MX1/ACTB/HLA-DPA1/CCL2/HLA-DMA	-0.14906919014553
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/345	86/9376	0.948028311425682	KCNMB4/GNAS/VAMP2	-0.0946314425822085
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/345	26/9376	1.04526198439242	APOA1	0.0451691297877114
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/345	87/9376	0.937131434282859	TGFBR1/AREG/RHOA	-0.115142581451641
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/345	119/9376	0.913506272074047	MMP9/IL1B/CCL2/MAP3K5	-0.185588144299297
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/345	28/9376	0.970600414078675	B4GALT3	-0.0304500592511502
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/345	60/9376	0.905893719806763	GNAS/GNAI2	-0.142924524803699
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/345	91/9376	0.895938843764931	GNG5/GNAS/GNAI2	-0.194960061781402
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/345	122/9376	0.89104300308862	WNT4/RHEB/ACTB/TBC1D4	-0.236754126354532
NA	NA	hsa04517	IgSF CAM signaling	10/345	299/9376	0.90892346468906	MYL12A/RAP1B/ACTB/NFASC/MYL12B/ARPC3/ARPC1B/RHOA/UNC5B/MYL9	-0.312822650974034
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/345	154/9376	0.882364012798795	DHRS3/MOCS2/NME1/UGDH/CMPK1	-0.287683707821352
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/345	30/9376	0.905893719806763	PIGP	-0.100900567925529
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/345	30/9376	0.905893719806763	IL1B	-0.100900567925529
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/345	63/9376	0.862755923625489	WNT4/WNT6	-0.213622181959355
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/345	155/9376	0.876671341748481	WNT4/RAP1B/WNT6/GNAS/GNAI2	-0.302599432573584
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/345	156/9376	0.871051653660349	CD81/MX1/CLDN4/YWHAH/IFIT1	-0.317424087850503
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/345	31/9376	0.876671341748481	SMOX	-0.134425749098107
NA	NA	hsa04981	Folate transport and metabolism	1/345	31/9376	0.876671341748481	MTHFS	-0.134425749098107
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/345	158/9376	0.860025683360851	CDKN1C/SKP1/RBX1/YWHAH/ANAPC11	-0.346805368844995
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/345	128/9376	0.849275362318841	NUDT16/NME1/NUDT2/DGUOK	-0.335577309257852
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/345	32/9376	0.849275362318841	MCEE	-0.166924501306251
NA	NA	hsa04081	Hormone signaling	7/345	219/9376	0.868665210773609	PRL/PRLR/SLC40A1/GNG5/GNAS/RHOA/GNAI2	-0.384372666332584
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/345	98/9376	0.831943212067436	CALM2/CALM3/GNAS	-0.326865569911319
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/345	33/9376	0.823539745278876	VAMP2	-0.198466843209199
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/345	68/9376	0.799317988064791	DHRS3/CYP3A5	-0.324610063814491
NA	NA	hsa04519	Cadherin signaling	13/345	404/9376	0.874501363179796	KRT23/WNT4/GJA1/PCDH20/WNT6/ACTB/YWHAH/ARPC3/RRAS/DAAM1/ARPC1B/RHOA/PPP1CB	-0.503978863903477
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/345	35/9376	0.77648033126294	HSD17B14	-0.25892879240445
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/345	36/9376	0.754911433172303	UGDH	-0.287957324086927
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/345	71/9376	0.765543988569096	PRL/PRLR	-0.387578451027116
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/345	168/9376	0.808833678398896	FTH1/GLUL/IL1B/CHMP5/FTL	-0.488664324190298
NA	NA	hsa04082	Neuroactive ligand signaling	6/345	199/9376	0.819401354599082	GNG5/HTR2B/SLC1A2/GNAS/SLC1A1/GNAI2	-0.503289564377033
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/345	72/9376	0.754911433172303	ISG15/PIN1	-0.408020246804854
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/345	37/9376	0.734508421464943	GLUL	-0.316248656082261
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/345	170/9376	0.799317988064791	WNT4/TGFBR1/WNT6/MGST1/ACTB	-0.516089099642508
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/345	73/9376	0.744570180663093	PDGFC/PDGFD	-0.428202087718728
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/345	38/9376	0.715179252479024	SGK1	-0.343845820689417
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/345	38/9376	0.715179252479024	UNG	-0.343845820689417
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/345	75/9376	0.724714975845411	GLUL/ARG1	-0.467816634187444
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/345	75/9376	0.724714975845411	MGST1/MAP3K5	-0.467816634187444
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/345	39/9376	0.696841322928279	MTHFS	-0.370788189125161
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/345	76/9376	0.715179252479024	CALM2/CALM3	-0.487263867975747
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/345	110/9376	0.741185770750988	CPEB4/ANAPC11/GNAI2	-0.533661175876733
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/345	144/9376	0.754911433172303	IL1B/LY96/C1QB/MAP3K5	-0.579273504928535
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	11/345	362/9376	0.825814716950917	PRL/PRLR/RHEB/SGK1/ITGA1/COL4A6/GNG5/YWHAH/PDGFC/AREG/PDGFD	-0.660593401906833
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/345	41/9376	0.662849063273241	MMP9	-0.422850065749075
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/345	78/9376	0.696841322928279	IMPA2/IP6K3	-0.525472264763537
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/345	80/9376	0.679420289855073	PDGFC/PDGFD	-0.562807961649929
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/345	117/9376	0.696841322928279	ACTB/ACTR6/MORF4L1	-0.644923432291167
NA	NA	hsa04382	Cornified envelope formation	6/345	217/9376	0.751432578641555	KRT23/S100A6/S100A11/S100A1/CLDN4/COL4A6	-0.724064589866906
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/345	47/9376	0.578230033919211	HAGH	-0.566544852178068
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/345	254/9376	0.748967248659135	CALM2/CALM3/PHKG1/HTR2B/PDGFC/GNAS/PDGFD	-0.792737631859809
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/345	122/9376	0.668282252316465	IGFBP3/GNAS/GNAI2	-0.720793962529869
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/345	48/9376	0.566183574879227	MCEE	-0.588924478162414
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/345	89/9376	0.610714867285458	ITGA1/COL4A6	-0.721194428430666
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/345	160/9376	0.679420289855073	CLDN4/NFASC/HLA-DPA1/HLA-DMA	-0.799377747987837
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/345	52/9376	0.52263099219621	GNAS	-0.674655435828477
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/345	93/9376	0.584447561165654	HLA-DPA1/HLA-DMA	-0.7871371303118
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/345	56/9376	0.485300207039337	GAS1	-0.755035402398336
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/345	99/9376	0.549026496852584	MMP9/GNAS	-0.88164167165336
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/345	103/9376	0.527705079499085	RBM8A/PPP1CB	-0.941995920185403
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/345	143/9376	0.570142900577683	HLA-DPA1/HLA-DMA/C1QB	-1.01239028597971
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/345	63/9376	0.431377961812744	GPX4	-0.885067565147726
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/345	183/9376	0.594028668725746	NOP10/SBDS/CSNK2B/REXO2	-1.08397569675654
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/345	65/9376	0.418104793756968	PLPP3	-0.920090526277962
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/345	65/9376	0.418104793756968	GNAS	-0.920090526277962
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/345	109/9376	0.498657093471613	PPP1CB/TBC1D4	-1.02897732975904
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/345	150/9376	0.543536231884058	WNT4/TGFBR1/WNT6	-1.10146951044238
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/345	115/9376	0.472640201638311	GNG5/GNAI2	-1.11212668683681
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/345	116/9376	0.468565717141429	PGD/MCEE	-1.12564211422387
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/345	157/9376	0.519302132373304	SGK1/ARG1/C1QB	-1.18715487133283
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	4/345	196/9376	0.554628808044957	CALM2/CALM3/GNG5/UBA52	-1.23156143706168
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/345	75/9376	0.362357487922705	GNAS	-1.08360334795152
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/345	122/9376	0.44552150154431	CAB39L/RHEB	-1.20483379870521
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/345	77/9376	0.352945605119518	TGFBR1	-1.1142824609107
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/345	77/9376	0.352945605119518	TGFBR1	-1.1142824609107
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/345	205/9376	0.530279250618593	B2M/ISG15/HLA-DPA1/HLA-DMA	-1.32903247618719
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/345	133/9376	0.408673858559442	KLRC3/TYROBP	-1.34237448059963
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/345	86/9376	0.316009437141894	AREG	-1.24542833707091
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/345	370/9376	0.587606737171955	PRL/PRLR/TSPO/PGRMC2/ADM/GAL/CNR1/HTR2B	-1.58188066218854
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/345	90/9376	0.301964573268921	RHEB	-1.30050385585756
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/345	90/9376	0.301964573268921	GNAS	-1.30050385585756
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/345	90/9376	0.301964573268921	CSNK2B	-1.30050385585756
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/345	91/9376	0.298646281254977	CD81	-1.31399620458056
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/345	93/9376	0.292223780582827	COL4A6	-1.34066579856376
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/345	144/9376	0.377455716586151	WNT4/WNT6	-1.47140037454252
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/345	148/9376	0.367254210732472	WNT4/WNT6	-1.51646919665687
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/345	104/9376	0.261315496098105	PLPP3	-1.48052658871291
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/345	201/9376	0.405624053644819	MMP9/IGFBP3/IL1R2	-1.66488209461405
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	3/345	205/9376	0.397709437963945	YWHAH/GTF2A2/RHOA	-1.70412679895686
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/345	108/9376	0.251637144390768	RBM8A	-1.52882703263706
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/345	163/9376	0.333457810971815	MMP9/TGFBR1	-1.67783084702056
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/345	168/9376	0.323533471359558	PRL/PRLR	-1.72920133780264
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/345	217/9376	0.375716289320777	MGST1/GNAS/GNAI2	-1.81850753595624
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/345	122/9376	0.222760750772155	RHOA	-1.68887363488054
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/345	195/9376	0.278736529171312	ACTB/CAMP	-1.98926899637131
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/345	323/9376	0.33655494234307	TIMP3/MMP9/MAPK7/RHOA	-2.3715769940416
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/345	449/9376	0.121054840063265	CALM2/CALM3	-3.73043473833795