category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	2/4	204/9376	22.9803921568627	VAV3/ITPR1	6.55719336986295
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	2/4	216/9376	21.7037037037037	VAV3/ITPR1	6.35955424940412
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/4	60/9376	39.0666666666667	ITPR1	6.11090072403869
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/4	63/9376	37.2063492063492	PRDM2	5.95675451915312
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/4	65/9376	36.0615384615385	ITPR1	5.85988343948957
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/4	65/9376	36.0615384615385	ITPR1	5.85988343948957
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/4	67/9376	34.9850746268657	ITPR1	5.76731414478601
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/4	69/9376	33.9710144927536	VAV3	5.67873356042585
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/4	69/9376	33.9710144927536	ITPR1	5.67873356042585
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/4	75/9376	31.2533333333333	ITPR1	5.43423650940973
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/4	76/9376	30.8421052631579	ITPR1	5.39627748539267
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/4	78/9376	30.0512820512821	ZCCHC7	5.32252030802579
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/4	89/9376	26.3370786516854	ITPR1	4.96150363666152
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/4	91/9376	25.7582417582418	VAV3	4.90285484283609
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/4	93/9376	25.2043010752688	ITPR1	4.84606616483396
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/4	93/9376	25.2043010752688	ITPR1	4.84606616483396
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/4	97/9376	24.1649484536082	ITPR1	4.73768423554816
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/4	98/9376	23.9183673469388	ITPR1	4.71160662625837
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/4	98/9376	23.9183673469388	VAV3	4.71160662625837
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/4	98/9376	23.9183673469388	ITPR1	4.71160662625837
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/4	99/9376	23.6767676767677	ITPR1	4.68591561696917
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/4	102/9376	22.9803921568627	ITPR1	4.61106740157811
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/4	105/9376	22.3238095238095	ITPR1	4.53937067172441
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/4	107/9376	21.9065420560748	ITPR1	4.49321446229236
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/4	115/9376	20.3826086956522	ITPR1	4.32047702573839
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/4	115/9376	20.3826086956522	ITPR1	4.32047702573839
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/4	115/9376	20.3826086956522	ITPR1	4.32047702573839
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/4	116/9376	20.2068965517241	VAV3	4.3001162096713
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/4	116/9376	20.2068965517241	ITPR1	4.3001162096713
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/4	122/9376	19.2131147540984	VAV3	4.18310615252147
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/4	122/9376	19.2131147540984	ITPR1	4.18310615252147
Organismal Systems	Immune system	hsa04611	Platelet activation	1/4	126/9376	18.6031746031746	ITPR1	4.1096505696617
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/4	133/9376	17.6240601503759	VAV3	3.98892563119861
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/4	133/9376	17.6240601503759	ITPR1	3.98892563119861
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/4	134/9376	17.4925373134328	ITPR1	3.97243121897426
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/4	137/9376	17.1094890510949	ITPR1	3.92400055316472
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/4	138/9376	16.9855072463768	ITPR1	3.90819729537518
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	1/4	138/9376	16.9855072463768	VAV3	3.90819729537518
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	1/4	139/9376	16.863309352518	ITPR1	3.89255910595418
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/4	140/9376	16.7428571428571	ITPR1	3.87708305091129
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/4	142/9376	16.5070422535211	ITPR1	3.84660596944626
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/4	144/9376	16.2777777777778	ITPR1	3.81674399318434
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/4	149/9376	15.7315436241611	ITPR1	3.74464475844811
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/4	154/9376	15.2207792207792	ITPR1	3.67595925872214
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/4	155/9376	15.1225806451613	ITPR1	3.66260762639953
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/4	157/9376	14.9299363057325	ITPR1	3.63627351912816
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/4	166/9376	14.1204819277108	ITPR1	3.52349378832312
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/4	169/9376	13.8698224852071	ITPR1	3.48783821125392
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/4	187/9376	12.5347593582888	ITPR1	3.29150644624789
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/4	193/9376	12.1450777202073	VAV3	3.23198218046588
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	1/4	196/9376	11.9591836734694	ITPR1	3.20320249924291
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	1/4	203/9376	11.5467980295567	VAV3	3.13842999247056
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	1/4	212/9376	11.0566037735849	VAV3	3.05968152064884
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	1/4	214/9376	10.9532710280374	ITPR1	3.04282563872134
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/4	226/9376	10.3716814159292	VAV3	2.94618953852532
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	1/4	227/9376	10.3259911894273	ITPR1	2.93846559080499
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	1/4	232/9376	10.1034482758621	VAV3	2.90055634710215
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	1/4	253/9376	9.26482213438735	ITPR1	2.75311548222969
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/4	254/9376	9.22834645669291	ITPR1	2.74652709484677
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/4	268/9376	8.74626865671642	ITPR1	2.65795690436903
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	1/4	275/9376	8.52363636363636	ITPR1	2.61606831300753
NA	NA	hsa04517	IgSF CAM signaling	1/4	299/9376	7.83946488294314	VAV3	2.48305331345673
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/4	308/9376	7.61038961038961	ITPR1	2.4369473903493
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	1/4	388/9376	6.04123711340206	ITPR1	2.09517811802263
NA	NA	hsa04519	Cadherin signaling	1/4	404/9376	5.8019801980198	VAV3	2.03828969502252
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	1/4	480/9376	4.88333333333333	ITPR1	1.804377471598