category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Cellular Processes Transport and catabolism hsa04148 Efferocytosis 6/96 157/9376 3.73248407643312 ATP11A/GULP1/ATP8A1/ARG2/VPS41/DUSP5 3.51166294616183 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 6/96 170/9376 3.44705882352941 MAP3K5/PATJ/CLDN10/MAGI1/TJP1/RAPGEF6 3.27476885447658 Human Diseases Cancer: specific types hsa05219 Bladder cancer 3/96 41/9376 7.14634146341463 DAPK1/VEGFA/MMP9 4.01142537966514 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 4/96 93/9376 4.20071684587814 MET/SMAD3/LMO7/TJP1 3.15494520822721 Organismal Systems Digestive system hsa04974 Protein digestion and absorption 4/96 103/9376 3.79288025889968 SLC1A1/COL14A1/DPP4/SLC3A1 2.89873200338646 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 6/96 212/9376 2.76415094339623 PRKD1/VEGFA/MET/MAGI1/RAPGEF5/RAPGEF6 2.6424598548971 NA NA hsa04382 Cornified envelope formation 6/96 217/9376 2.70046082949309 PPP2R5A/LAMB3/CLDN10/KRT7/TJP1/SPTLC3 2.57762500642759 NA NA hsa04517 IgSF CAM signaling 7/96 299/9376 2.28651059085842 LRRC4C/SRGAP1/GRIP1/LMO7/MAGI1/TJP1/RAPGEF6 2.29945576196972 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 7/96 300/9376 2.27888888888889 MAP4K3/MAP3K5/VEGFA/MET/TGFB2/DUSP5/PPM1B 2.28977845430001 Human Diseases Cancer: specific types hsa05211 Renal cell carcinoma 3/96 70/9376 4.18571428571429 VEGFA/MET/TGFB2 2.7209564172625 Cellular Processes Transport and catabolism hsa04142 Lysosome biogenesis 6/96 250/9376 2.344 TPCN1/MITF/DEPTOR/VPS41/SLC15A4/GNPTAB 2.1906667040057 Human Diseases Cancer: specific types hsa05212 Pancreatic cancer 3/96 77/9376 3.80519480519481 VEGFA/SMAD3/TGFB2 2.51383941486477 Organismal Systems Nervous system hsa04721 Synaptic vesicle cycle 3/96 79/9376 3.70886075949367 SLC1A1/SLC18A2/UNC13B 2.45909937164729 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 7/96 323/9376 2.11661506707946 VEGFA/MET/CYP24A1/FOXP1/TGFB2/MDM4/MMP9 2.07709208741155 NA NA hsa04518 Integrin signaling 4/96 154/9376 2.53679653679654 LAMB3/VEGFA/MET/FLNB 1.95574145428526 Environmental Information Processing Signal transduction hsa04390 Hippo signaling pathway 4/96 157/9376 2.48832271762208 WWC1/PATJ/SMAD3/TGFB2 1.91272395125054 Human Diseases Endocrine and metabolic disease hsa04933 AGE-RAGE signaling pathway in diabetic complications 3/96 101/9376 2.9009900990099 VEGFA/SMAD3/TGFB2 1.95357842018107 NA NA hsa03272 Virion - Hepatitis viruses 2/96 48/9376 4.06944444444444 CLDN10/DPP4 2.16837001886708 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 3/96 103/9376 2.84466019417476 LAMB3/ARG2/TGFB2 1.91457386086939 Human Diseases Infectious disease: parasitic hsa05144 Malaria 2/96 50/9376 3.90666666666667 MET/TGFB2 2.0959445721953 Cellular Processes Transport and catabolism hsa04140 Autophagy - animal 4/96 169/9376 2.31163708086785 DEPTOR/DAPK1/VPS41/WDFY3 1.7500289508569 Environmental Information Processing Signal transduction hsa04340 Hedgehog signaling pathway 2/96 56/9376 3.48809523809524 EVC/GLI3 1.89932954512579 Environmental Information Processing Signal transduction hsa04668 TNF signaling pathway 3/96 119/9376 2.46218487394958 MAP3K5/DAB2IP/MMP9 1.63263048803361 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 6/96 333/9376 1.75975975975976 PPP2R5A/LAMB3/VEGFA/PATJ/MAML3/MAGI1 1.43578497941367 Environmental Information Processing Signal transduction hsa04071 Sphingolipid signaling pathway 3/96 125/9376 2.344 PPP2R5A/MAP3K5/SPTLC3 1.5385343656269 Human Diseases Immune disease hsa05321 Inflammatory bowel disease 2/96 66/9376 2.95959595959596 SMAD3/TGFB2 1.62484122459998 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 4/96 201/9376 1.94361525704809 MITF/MET/PAX8/MMP9 1.37542594761523 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 4/96 203/9376 1.92446633825944 LAMB3/VEGFA/MET/FLNB 1.35434931066243 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 4/96 204/9376 1.91503267973856 VEGFA/MET/TGFB2/MMP9 1.34389993259307 Metabolism Energy metabolism hsa00910 Nitrogen metabolism 1/96 17/9376 5.74509803921569 CA12 1.99160034824932 Human Diseases Infectious disease: bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection 2/96 71/9376 2.75117370892019 MET/TJP1 1.5064248826483 Cellular Processes Cell growth and death hsa04210 Apoptosis 3/96 137/9376 2.13868613138686 MAP3K5/DAB2IP/TNFRSF10B 1.36552324623989 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 6/96 362/9376 1.61878453038674 PRL/PPP2R5A/LAMB3/VEGFA/MET/MAGI1 1.22118714168821 Human Diseases Cancer: specific types hsa05218 Melanoma 2/96 73/9376 2.67579908675799 MITF/MET 1.46190494657457 Human Diseases Cancer: specific types hsa05223 Non-small cell lung cancer 2/96 73/9376 2.67579908675799 MET/EML4 1.46190494657457 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 3/96 142/9376 2.06338028169014 MAP3K5/VEGFA/MMP9 1.29862902877652 Cellular Processes Cell growth and death hsa04115 p53 signaling pathway 2/96 75/9376 2.60444444444444 MDM4/TNFRSF10B 1.41885416673345 Organismal Systems Endocrine system hsa04918 Thyroid hormone synthesis 2/96 75/9376 2.60444444444444 GPX3/PAX8 1.41885416673345 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 4/96 216/9376 1.80864197530864 APOA1/MAP3K5/TNFRSF10B/MMP9 1.22287674558733 Metabolism Lipid metabolism hsa00100 Steroid biosynthesis 1/96 20/9376 4.88333333333333 CYP24A1 1.76816108684112 Human Diseases Cancer: specific types hsa05220 Chronic myeloid leukemia 2/96 77/9376 2.53679653679654 SMAD3/TGFB2 1.37718054363734 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 5/96 298/9376 1.63870246085011 PRL/LEPR/IL6ST/TGFB2/TNFRSF10B 1.13961694694493 Metabolism Glycan biosynthesis and metabolism hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/96 21/9376 4.65079365079365 CSGALNACT1 1.70342220665092 Human Diseases Drug resistance: antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance 2/96 80/9376 2.44166666666667 VEGFA/MET 1.31707061285951 Human Diseases Cancer: specific types hsa05226 Gastric cancer 3/96 150/9376 1.95333333333333 MET/SMAD3/TGFB2 1.19710142950682 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 4/96 227/9376 1.72099853157122 PRKD1/MAP3K5/VEGFA/MET 1.11842730585866 Genetic Information Processing Chromosome hsa03083 Polycomb repressive complex 2/96 83/9376 2.35341365461847 L3MBTL4/SCMH1 1.25961811572978 Metabolism Amino acid metabolism hsa00220 Arginine biosynthesis 1/96 23/9376 4.2463768115942 ARG2 1.5853846357209 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 4/96 233/9376 1.67668097281831 PDLIM5/NID2/SNTB1/SYNE2 1.06381187089956 Metabolism Glycan biosynthesis and metabolism hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1/96 24/9376 4.06944444444444 HS6ST3 1.53130046937996 Cellular Processes Cell growth and death hsa04110 Cell cycle 3/96 158/9376 1.85443037974684 PPP2R5A/SMAD3/TGFB2 1.10162590455582 Human Diseases Cancer: specific types hsa05210 Colorectal cancer 2/96 87/9376 2.24521072796935 SMAD3/TGFB2 1.18676646324943 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 4/96 238/9376 1.64145658263305 VEGFA/MET/ETS2/RAPGEF5 1.01947700521198 Organismal Systems Nervous system hsa04727 GABAergic synapse 2/96 89/9376 2.19475655430712 GABRP/HAP1 1.15181828558674 NA NA hsa04519 Cadherin signaling 6/96 404/9376 1.45049504950495 GABRP/WWC1/ERBIN/MET/KRT7/TJP1 0.94141982473182 Human Diseases Infectious disease: viral hsa05161 Hepatitis B 3/96 163/9376 1.79754601226994 SMAD3/TGFB2/MMP9 1.04471127331354 Human Diseases Endocrine and metabolic disease hsa04950 Maturity onset diabetes of the young 1/96 26/9376 3.75641025641026 HNF1B 1.43143618803609 Organismal Systems Digestive system hsa04977 Vitamin digestion and absorption 1/96 26/9376 3.75641025641026 APOA1 1.43143618803609 Metabolism Lipid metabolism hsa01040 Biosynthesis of unsaturated fatty acids 1/96 27/9376 3.61728395061728 ELOVL7 1.38515192798492 Environmental Information Processing Signal transduction hsa04630 JAK-STAT signaling pathway 3/96 168/9376 1.74404761904762 PRL/LEPR/IL6ST 0.989737404183957 Metabolism Lipid metabolism hsa00062 Fatty acid elongation 1/96 28/9376 3.48809523809524 ELOVL7 1.34101591017873 Human Diseases Cancer: specific types hsa05225 Hepatocellular carcinoma 3/96 170/9376 1.72352941176471 MET/SMAD3/TGFB2 0.968260983414952 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 2/96 95/9376 2.05614035087719 VEGFA/TGFB2 1.05228485170468 Environmental Information Processing Signal transduction hsa04392 Hippo signaling pathway - multiple species 1/96 29/9376 3.36781609195402 WWC1 1.29884734803709 Genetic Information Processing Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum 3/96 174/9376 1.68390804597701 MAP3K5/PRKN/UGGT2 0.926143940056506 Human Diseases Drug resistance: antineoplastic hsa01522 Endocrine resistance 2/96 99/9376 1.97306397306397 NCOA3/MMP9 0.98992542577921 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 2/96 99/9376 1.97306397306397 TGFB2/SNTB1 0.98992542577921 Environmental Information Processing Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor 2/96 100/9376 1.95333333333333 IL6ST/TNFRSF10B 0.974791368636689 Genetic Information Processing Folding, sorting and degradation hsa03060 Protein export 1/96 31/9376 3.1505376344086 IMMP2L 1.21979123342088 Organismal Systems Development and regeneration hsa04360 Axon guidance 3/96 184/9376 1.59239130434783 LRRC4C/SRGAP1/MET 0.825391220751492 Cellular Processes Transport and catabolism hsa04137 Mitophagy - animal 2/96 105/9376 1.86031746031746 MITF/PRKN 0.901648703808093 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 2/96 105/9376 1.86031746031746 TGFB2/SNTB1 0.901648703808093 Organismal Systems Immune system hsa04659 Th17 cell differentiation 2/96 109/9376 1.79204892966361 SMAD3/IL6ST 0.84594659265895 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 2/96 110/9376 1.77575757575758 SMAD3/TGFB2 0.832383545822741 Metabolism Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism 1/96 37/9376 2.63963963963964 RIMKLB 1.01635715794651 Human Diseases Infectious disease: parasitic hsa05143 African trypanosomiasis 1/96 37/9376 2.63963963963964 APOA1 1.01635715794651 Human Diseases Cancer: specific types hsa05216 Thyroid cancer 1/96 37/9376 2.63963963963964 PAX8 1.01635715794651 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 2/96 112/9376 1.74404761904762 LAMB3/TGFB2 0.805671008295235 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 5/96 368/9376 1.32699275362319 MAP3K5/GPX3/HAP1/PRKN/DNAH14 0.650871290773362 NA NA hsa04082 Neuroactive ligand signaling 3/96 199/9376 1.47236180904523 GABRP/SLC1A1/SLC18A2 0.685012057805789 Organismal Systems Immune system hsa04670 Leukocyte transendothelial migration 2/96 116/9376 1.68390804597701 CLDN10/MMP9 0.753821432378147 Organismal Systems Nervous system hsa04724 Glutamatergic synapse 2/96 116/9376 1.68390804597701 SLC1A1/DLGAP1 0.753821432378147 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 3/96 200/9376 1.465 CLDN10/TNFRSF10B/TJP1 0.676065096307656 Genetic Information Processing Chromosome hsa03082 ATP-dependent chromatin remodeling 2/96 117/9376 1.66951566951567 CECR2/INO80 0.741171824326881 Human Diseases Substance dependence hsa05033 Nicotine addiction 1/96 41/9376 2.38211382113821 GABRP 0.90204009860195 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 3/96 205/9376 1.42926829268293 SMAD3/TGFB2/MMP9 0.632040141318768 Environmental Information Processing Signal transduction hsa04152 AMPK signaling pathway 2/96 122/9376 1.60109289617486 PPP2R5A/LEPR 0.679679278626042 Organismal Systems Endocrine system hsa04919 Thyroid hormone signaling pathway 2/96 122/9376 1.60109289617486 THRB/NCOA3 0.679679278626042 Organismal Systems Digestive system hsa04975 Fat digestion and absorption 1/96 43/9376 2.27131782945736 APOA1 0.849816187221866 Metabolism Glycan biosynthesis and metabolism hsa00513 Various types of N-glycan biosynthesis 1/96 44/9376 2.21969696969697 B4GALNT3 0.824780120356578 Environmental Information Processing Membrane transport hsa02010 ABC transporters 1/96 45/9376 2.17037037037037 ABCA6 0.800410444801783 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 2/96 130/9376 1.5025641025641 VEGFA/MMP9 0.586858585537244 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 4/96 308/9376 1.26839826839827 MAP3K5/GPX3/HAP1/DNAH14 0.487131909324167 NA NA hsa04081 Hormone signaling 3/96 219/9376 1.337899543379 PRL/LEPR/THRB 0.514612489050811 Environmental Information Processing Signal transduction hsa04068 FoxO signaling pathway 2/96 133/9376 1.468671679198 SMAD3/TGFB2 0.55365002189372 Organismal Systems Nervous system hsa04728 Dopaminergic synapse 2/96 133/9376 1.468671679198 SLC18A2/PPP2R5A 0.55365002189372 Human Diseases Substance dependence hsa05030 Cocaine addiction 1/96 49/9376 1.99319727891156 SLC18A2 0.708940584981888 Metabolism Amino acid metabolism hsa00330 Arginine and proline metabolism 1/96 50/9376 1.95333333333333 ARG2 0.687431361981485 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 3/96 224/9376 1.30803571428571 SMAD3/ETS2/TGFB2 0.474585365983753 Human Diseases Infectious disease: bacterial hsa05110 Vibrio cholerae infection 1/96 51/9376 1.91503267973856 TJP1 0.666414655440443 Organismal Systems Digestive system hsa04979 Cholesterol metabolism 1/96 52/9376 1.87820512820513 APOA1 0.645868010655885 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 2/96 139/9376 1.4052757793765 NCOA3/MMP9 0.489598236190014 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 2/96 142/9376 1.37558685446009 MITF/TGFB2 0.458676919656165 Metabolism Lipid metabolism hsa00600 Sphingolipid metabolism 1/96 55/9376 1.77575757575758 SPTLC3 0.586844965026883 Cellular Processes Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells 2/96 144/9376 1.35648148148148 SMAD3/IL6ST 0.438447490583965 Metabolism Global and overview maps hsa01212 Fatty acid metabolism 1/96 57/9376 1.71345029239766 ELOVL7 0.549495017517394 Metabolism Metabolism of other amino acids hsa00480 Glutathione metabolism 1/96 59/9376 1.65536723163842 GPX3 0.513594007159962 Environmental Information Processing Signal transduction hsa04370 VEGF signaling pathway 1/96 60/9376 1.62777777777778 VEGFA 0.496151250456385 Environmental Information Processing Signal transduction hsa04330 Notch signaling pathway 1/96 62/9376 1.5752688172043 MAML3 0.462216908003566 Human Diseases Cancer: specific types hsa05217 Basal cell carcinoma 1/96 63/9376 1.55026455026455 GLI3 0.445701683995679 Cellular Processes Cell growth and death hsa04218 Cellular senescence 2/96 157/9376 1.24416135881104 SMAD3/TGFB2 0.313784956339247 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 2/96 157/9376 1.24416135881104 MAP3K5/LEPR 0.313784956339247 Environmental Information Processing Signal transduction hsa04150 mTOR signaling pathway 2/96 158/9376 1.23628691983122 DEPTOR/FNIP2 0.304647163729017 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 3/96 254/9376 1.15354330708661 TPCN1/VEGFA/MET 0.252319015453082 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 2/96 160/9376 1.22083333333333 LRRC4C/CLDN10 0.286550158349493 Metabolism Lipid metabolism hsa00140 Steroid hormone biosynthesis 1/96 66/9376 1.47979797979798 CYP3A5 0.397834835920098 Metabolism Metabolism of cofactors and vitamins hsa00830 Retinol metabolism 1/96 68/9376 1.43627450980392 CYP3A5 0.367225960034871 Human Diseases Substance dependence hsa05031 Amphetamine addiction 1/96 69/9376 1.41545893719807 SLC18A2 0.352285737455608 Organismal Systems Endocrine system hsa04920 Adipocytokine signaling pathway 1/96 70/9376 1.3952380952381 LEPR 0.337577552515377 Human Diseases Cancer: overview hsa05204 Chemical carcinogenesis - DNA adducts 1/96 70/9376 1.3952380952381 CYP3A5 0.337577552515377 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 1/96 70/9376 1.3952380952381 SNTB1 0.337577552515377 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 1/96 71/9376 1.37558685446009 PRL 0.323093808610895 Human Diseases Cancer: overview hsa05230 Central carbon metabolism in cancer 1/96 71/9376 1.37558685446009 MET 0.323093808610895 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 3/96 268/9376 1.09328358208955 SLC18A2/MAP3K5/PRKN 0.157582638297144 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 4/96 370/9376 1.05585585585586 PRL/GABRP/LEPR/THRB 0.111493838621387 Metabolism Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450 1/96 73/9376 1.337899543379 CYP3A5 0.294771024649913 Metabolism Global and overview maps hsa01230 Biosynthesis of amino acids 1/96 75/9376 1.30222222222222 ARG2 0.267263388747575 Human Diseases Drug resistance: antineoplastic hsa01524 Platinum drug resistance 1/96 75/9376 1.30222222222222 MAP3K5 0.267263388747575 Organismal Systems Endocrine system hsa03320 PPAR signaling pathway 1/96 76/9376 1.28508771929825 APOA1 0.25379969632306 Environmental Information Processing Signal transduction hsa04310 Wnt signaling pathway 2/96 178/9376 1.09737827715356 LGR4/SMAD3 0.133405167279848 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 5/96 480/9376 1.01736111111111 MAP3K5/GPX3/HAP1/PRKN/DNAH14 0.0397144008308312 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 1/96 78/9376 1.25213675213675 MET 0.227423820646295 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 1/96 78/9376 1.25213675213675 TGFB2 0.227423820646295 Metabolism Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 1/96 79/9376 1.23628691983122 CYP3A5 0.214500879769857 Metabolism Global and overview maps hsa01232 Nucleotide metabolism 1/96 85/9376 1.14901960784314 ADK 0.140368259730404 Human Diseases Substance dependence hsa05034 Alcoholism 2/96 191/9376 1.02268760907504 SLC18A2/HDAC7 0.0322190774077474 Human Diseases Cardiovascular disease hsa05412 Arrhythmogenic right ventricular cardiomyopathy 1/96 86/9376 1.13565891472868 SNTB1 0.128539608736752 Cellular Processes Cell motility hsa04814 Motor proteins 2/96 194/9376 1.00687285223368 KIF12/DNAH14 0.00983821918705709 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 2/96 196/9376 0.996598639455782 VEGFA/IL6ST -0.00489448082336314 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 1/96 89/9376 1.09737827715356 LAMB3 0.0938786063487621 Cellular Processes Cellular community - eukaryotes hsa04540 Gap junction 1/96 89/9376 1.09737827715356 TJP1 0.0938786063487621 Human Diseases Cancer: overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 1/96 90/9376 1.08518518518519 EML4 0.0825882480557907 Human Diseases Substance dependence hsa05032 Morphine addiction 1/96 91/9376 1.07326007326007 GABRP 0.0714240310451983 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 1/96 93/9376 1.05017921146953 MAML3 0.0494616270046819 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 1/96 93/9376 1.05017921146953 LAMB3 0.0494616270046819 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 1/96 94/9376 1.03900709219858 MMP9 0.0386575199075541 Human Diseases Cancer: overview hsa05203 Viral carcinogenesis 2/96 205/9376 0.952845528455284 IL6ST/HDAC7 -0.0694286518872889 Organismal Systems Endocrine system hsa04925 Aldosterone synthesis and secretion 1/96 98/9376 0.996598639455782 PRKD1 -0.00344259386092273 Human Diseases Cancer: overview hsa05231 Choline metabolism in cancer 1/96 99/9376 0.986531986531987 SLC44A1 -0.0137013899761828 Organismal Systems Endocrine system hsa04916 Melanogenesis 1/96 101/9376 0.966996699669967 MITF -0.0339162920170326 Genetic Information Processing Translation hsa03015 mRNA surveillance pathway 1/96 103/9376 0.948220064724919 PPP2R5A -0.0537424241647547 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 1/96 103/9376 0.948220064724919 TGFB2 -0.0537424241647547 Human Diseases Cancer: specific types hsa05215 Prostate cancer 1/96 106/9376 0.921383647798742 MMP9 -0.0827891113334844 Genetic Information Processing Translation hsa03013 Nucleocytoplasmic transport 1/96 108/9376 0.904320987654321 RANBP17 -0.101714487552996 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 1/96 110/9376 0.887878787878788 VEGFA -0.120305434357193 Organismal Systems Nervous system hsa04726 Serotonergic synapse 1/96 115/9376 0.849275362318841 SLC18A2 -0.165406089114966 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 1/96 115/9376 0.849275362318841 CYP24A1 -0.165406089114966 Organismal Systems Nervous system hsa04722 Neurotrophin signaling pathway 1/96 120/9376 0.813888888888889 MAP3K5 -0.208688500541353 Organismal Systems Immune system hsa04660 T cell receptor signaling pathway 1/96 122/9376 0.800546448087432 PPP2R5A -0.225529942453186 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 2/96 248/9376 0.787634408602151 VPS41/TNFRSF10B -0.344722350806429 Metabolism Nucleotide metabolism hsa00230 Purine metabolism 1/96 128/9376 0.763020833333333 ADK -0.274560785621203 Organismal Systems Immune system hsa04650 Natural killer cell mediated cytotoxicity 1/96 133/9376 0.734335839598998 TNFRSF10B -0.313833702249916 Cellular Processes Cell growth and death hsa04114 Oocyte meiosis 1/96 138/9376 0.707729468599034 PPP2R5A -0.351789489708625 Environmental Information Processing Signal transduction hsa04371 Apelin signaling pathway 1/96 140/9376 0.697619047619048 SMAD3 -0.366626415613811 Genetic Information Processing Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis 1/96 142/9376 0.687793427230047 PRKN -0.381275189464187 Human Diseases Endocrine and metabolic disease hsa04936 Alcoholic liver disease 1/96 144/9376 0.678240740740741 MAP3K5 -0.395741566176436 Human Diseases Neurodegenerative disease hsa05017 Spinocerebellar ataxia 1/96 144/9376 0.678240740740741 MAP3K5 -0.395741566176436 Human Diseases Cancer: specific types hsa05224 Breast cancer 1/96 148/9376 0.65990990990991 NCOA3 -0.424148864386309 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 1/96 149/9376 0.655480984340045 GABRP -0.431144984388108 Organismal Systems Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes 1/96 154/9376 0.634199134199134 PPP2R5A -0.465521557428463 Human Diseases Infectious disease: viral hsa05160 Hepatitis C 1/96 156/9376 0.626068376068376 CLDN10 -0.479000868518624 Cellular Processes Cell growth and death hsa04217 Necroptosis 1/96 168/9376 0.581349206349206 TNFRSF10B -0.556892246087507 Human Diseases Infectious disease: viral hsa05164 Influenza A 1/96 173/9376 0.564547206165703 TNFRSF10B -0.587958520581207 Human Diseases Infectious disease: bacterial hsa05152 Tuberculosis 1/96 181/9376 0.539594843462247 TGFB2 -0.63613730747005 Genetic Information Processing Translation hsa03008 Ribosome biogenesis in eukaryotes 1/96 183/9376 0.533697632058288 NOP58 -0.647905702353797 Organismal Systems Immune system hsa04621 NOD-like receptor signaling pathway 1/96 187/9376 0.522281639928699 ERBIN -0.67112880137519 Organismal Systems Immune system hsa04613 Neutrophil extracellular trap formation 1/96 195/9376 0.500854700854701 HDAC7 -0.716385132207276 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 1/96 217/9376 0.450076804915515 VEGFA -0.833595078862763 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 1/96 226/9376 0.432153392330383 GLI3 -0.878864606111891 Human Diseases Infectious disease: viral hsa05163 Human cytomegalovirus infection 1/96 227/9376 0.430249632892805 VEGFA -0.883808135790553 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 2/96 388/9376 0.503436426116838 MAP3K5/BACE2 -1.01602982272687 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 1/96 235/9376 0.415602836879433 MAP3K5 -0.922767823196854 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 1/96 238/9376 0.410364145658263 IL6ST -0.937117509157741 Cellular Processes Transport and catabolism hsa04144 Endocytosis 1/96 250/9376 0.390666666666667 SMAD3 -0.993189170367661