category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/343	155/9376	4.40891563998871	HLA-B/ATP6V0D2/HLA-A/HLA-C/ATP6V1A/CTSS/ATP6V1C1/HLA-DRA/ITGAV/ATP6V0C/ATP6V1F/CYBA/ATP6AP1/ATP6V1B2/ATP6V1H/TCIRG1/ATP6V1G1/HLA-F/HLA-E/CLEC7A/ITGB2/MRC1/ITGB5/ATP6V0B/ITGA2	8.33891957155775
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	32/343	250/9376	3.49891545189504	ACP5/LAPTM5/ATP6V0D2/CTSK/MAN2B1/ATP6V1A/CD68/MITF/GNPTAB/CTSS/ATP6V1C1/ATP6V0C/ATP6V1F/ATP6AP1/CTSD/ATP6V1B2/WDR7/TPP1/GLA/ATP6V1H/GNS/PSAP/TCIRG1/SUMF1/MANBA/ATP6V1G1/IDS/OSBPL3/AP1S3/ATP6V0B/OSBPL1A/AP1S2	7.80365440251269
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	19/343	95/9376	5.46705539358601	ACP5/ATP6V0D2/TNFRSF11A/CTSK/ATP6V1A/ATP6V1C1/HLA-DRA/ATP6V0C/ATP6V1F/CXCL3/ATP6AP1/ATP6V1B2/CCL3/ATP6V1H/TCIRG1/ATP6V1G1/VEGFA/ITGB2/ATP6V0B	8.52712142608467
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/343	138/9376	4.35779777749609	ATP6V0D2/ATP6V1A/ATP6V1C1/ATP6V0C/ATP6V1F/ATP6AP1/ATP6V1B2/ATP6V1H/MT-ND2/TCIRG1/ATP6V1G1/MT-ND5/MT-ND4/MT-ATP6/MT-CO2/NDUFB5/UQCRB/MT-ND1/ATP6V0B/ATP5ME/MT-CO1/MT-CO3	7.74322349588559
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	15/343	71/9376	5.77505851435141	ATP6V0D2/ATP6V1A/ATP6V1C1/ATP6V0C/ATP6V1F/NFKB1/CXCL3/ATP6AP1/NFKBIA/ATP6V1B2/ATP6V1H/TCIRG1/ATP6V1G1/MAPK8/ATP6V0B	7.86984858385732
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/343	51/9376	5.89584405190648	ATP6V0D2/ATP6V1A/ATP6V1C1/ATP6V0C/ATP6V1F/ATP6AP1/ATP6V1B2/ATP6V1H/TCIRG1/ATP6V1G1/ATP6V0B	6.83132483094873
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	23/343	216/9376	2.91070078825181	APOA1/MMP9/NFE2L2/HSPA1A/LY96/HSPA1B/NFATC1/NFKB1/CXCL3/CYBA/ATF6/NFKBIA/TANK/HSPD1/HSP90AA1/CCL3/PYCARD/ERN1/HSPA8/TAB2/CAMK2D/RAP1A/MAPK8	5.53590354561354
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	8/343	28/9376	7.81007913369429	ATP6V0D2/ATP6V1A/ATP6V1C1/ATP6V0C/ATP6V1F/ATP6V1B2/TCIRG1/ATP6V1G1	7.03215630633314
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/343	82/9376	4.33364147052549	HLA-B/HLA-A/HSPA1A/HLA-C/HSPA1B/CTSS/HLA-DRA/IFI30/HSP90AA1/CD74/HLA-F/HLA-E/HSPA8	5.90800936879005
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	23/343	227/9376	2.76965361349071	PTPRJ/NFE2L2/ABL2/NFKB1/CYBA/NFKBIA/MT-ND2/AHR/SLC25A6/HIF1A/PTPN1/MT-ND5/MT-ND4/MT-ATP6/MT-CO2/NDUFB5/UQCRB/VEGFA/MT-ND1/MAPK8/MT-CO1/PPIF/MT-CO3	5.25933791245251
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	21/343	196/9376	2.92877967513536	HLA-B/HLA-A/HLA-C/GNG2/GNB4/NFATC1/NFKB1/CXCL3/NFKBIA/CLEC2B/ZFP36/PIK3R5/SYK/HLA-F/HIF1A/PREX1/HLA-E/ITPR2/VEGFA/MAPK8/PIK3CG	5.31748176314703
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/343	181/9376	3.02047259314144	ATP6V0D2/CTSS/HLA-DRA/ATP6V0C/NFKB1/ATP6AP1/HSPD1/CTSD/ATP6V1H/CD74/CLEC4E/TCIRG1/FCER1G/SYK/CAMK2D/CLEC7A/ITGB2/MRC1/MAPK8/ATP6V0B	5.34851326872054
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	20/343	187/9376	2.92355903400321	TXNIP/NAMPT/NFKB1/CXCL3/CYBA/IFI16/NFKBIA/TANK/BIRC3/ANTXR2/HSP90AA1/PYCARD/GBP2/TNFAIP3/GPSM3/TAB2/ITPR2/PSTPIP1/CARD8/MAPK8	5.17736626941591
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	17/343	142/9376	3.27253315813247	TYROBP/ACP5/TNFRSF11A/CTSK/MITF/NFATC1/CSF1R/NFKB1/CYBA/NFKBIA/TEC1/LCP2/SYK/SPI1/TAB2/ITPR2/MAPK8	5.31711629029723
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/343	44/9376	5.59130665253114	HLA-B/HLA-A/HLA-C/HLA-DRA/ICA1/HSPD1/HLA-F/HLA-E/GZMB	5.9482877089377
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	23/343	250/9376	2.51484548104956	HLA-B/HLA-A/HSPA1A/HLA-C/HSPA1B/DNM1/RAB11FIP1/RAB31/AGAP3/SMAP2/CYTH4/HLA-F/CXCR4/HLA-E/HSPA8/ARRB1/SMURF2/EHD4/ARAP2/CHMP1B/SH3KBP1/CYTH1/EPS15	4.73058446149277
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	20/343	205/9376	2.66685628955415	MMP9/RAC2/NFKB1/CYBA/CTSD/TBC1D4/MT-ND2/SLC25A6/MT-ND5/MT-ND4/MT-ATP6/MT-CO2/NDUFB5/UQCRB/CAMK2D/MT-ND1/MAPK8/MT-CO1/PPIF/MT-CO3	4.70200877218139
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	20/343	214/9376	2.55469878204954	HLA-B/HLA-A/BST2/HLA-C/RAC2/GNG2/GNB4/NFATC1/NFKB1/NFKBIA/HLA-F/CXCR4/HLA-E/SAMHD1/TAB2/AP1S3/ITPR2/FBXW11/MAPK8/AP1S2	4.48306147631991
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/343	79/9376	3.80617780566114	ATP6V0D2/ATP6V1A/ATP6V1C1/ATP6V0C/ATP6V1F/DNM1/ATP6V1B2/ATP6V1H/TCIRG1/ATP6V1G1/ATP6V0B	4.88060891303696
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/343	56/9376	4.39316951270304	HSPA1A/HSPA1B/NFKB1/CXCL3/NFKBIA/HSPD1/PYCARD/HSPA8/ITGB2	4.96258897857747
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/343	112/9376	3.17284464806331	HSPA1A/LY96/HSPA1B/HLA-DRA/NFKB1/NFKBIA/BIRC3/PIK3R5/HSPA8/TAB2/MAPK8/PIK3CG/PPIF	4.5077010699705
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/343	160/9376	2.733527696793	HLA-B/CADM1/CD58/HLA-A/PTPRC/HLA-C/HLA-DRA/ITGAV/PTPRM/NRXN1/SELPLG/HLA-F/HLA-E/NCAM1/ITGB2/ALCAM	4.30959279258919
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	14/343	133/9376	2.87739757557158	HLA-B/TYROBP/HLA-A/HLA-C/RAC2/NFATC1/LAT2/FCER1G/LCP2/SYK/HLA-E/ITGB2/GZMB/LAT	4.24905438464835
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/343	105/9376	3.12403165347772	TNFRSF11A/LY96/NFKB1/CXCL3/NFKBIA/BIRC3/CFLAR/CCL4/SYK/TNFAIP3/TAB2/LAT	4.26490180716068
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/343	39/9376	4.90633176347462	HLA-B/HLA-A/HLA-C/HLA-DRA/HLA-F/HLA-E/GZMB	4.76337137208178
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/343	109/9376	3.00938829004734	NFATC1/HLA-DRA/NFKB1/NFKBIA/HSP90AA1/RUNX1/AHR/HIF1A/NFKBIE/IL6R/MAPK8/LAT	4.1117265818074
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/343	227/9376	2.28797472418798	HLA-B/HLA-A/HLA-C/RAC2/GNG2/GNB4/NFATC1/ITGAV/NFKB1/GNA13/NFKBIA/CCL3/CCL4/HLA-F/CXCR4/HLA-E/ITPR2/IL6R/VEGFA	3.82780802161652
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/343	70/9376	3.51453561016243	HLA-B/HLA-A/HLA-C/RAC2/ABL2/HLA-DRA/HLA-F/HLA-E/ITGB2	4.11473602947269
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/343	45/9376	4.25215419501134	HLA-B/HLA-A/HLA-C/HLA-DRA/HLA-F/HLA-E/GZMB	4.26118102041128
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/343	275/9376	2.08742115027829	HSPA1A/RAC2/HSPA1B/CYBA/C1QB/MT-ND2/SLC25A6/MT-ND5/MT-ND4/HSPA8/MT-ATP6/MT-CO2/NCAM1/NDUFB5/UQCRB/ITPR2/MT-ND1/MAPK8/MT-CO1/PPIF/MT-CO3	3.5664509755733
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	17/343	205/9376	2.26682784612103	HLA-B/CD58/HLA-A/HLA-C/HLA-DRA/NFKB1/VIM/NFKBIA/CD44/SYK/TNFAIP3/HLA-F/HLA-E/TAB2/NFKBIE/RUNX3/MAPK8	3.57357480823857
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	16/343	193/9376	2.26613695070923	RAC2/GNG2/GNB4/NFKB1/CXCL3/NFKBIA/CCL3/CCL4/DOCK2/PIK3R5/CXCR4/PREX1/ARRB1/TIAM1/RAP1A/PIK3CG	3.46324916987374
Organismal Systems	Immune system	hsa04611	Platelet activation	12/343	126/9376	2.60335971123143	TBXAS1/GNA13/FERMT3/FCER1G/LCP2/PIK3R5/SYK/ITPR2/RAP1A/APBB1IP/PIK3CG/ITGA2	3.53071014832675
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	15/343	180/9376	2.2779397473275	HLA-B/HLA-A/BST2/HLA-C/HLA-DRA/TNFRSF14/NFKB1/NFKBIA/BIRC3/CD74/SYK/HLA-F/HLA-E/SP100/TAB2	3.37336894417376
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	23/343	333/9376	1.88802213292009	HLA-B/ATP6V0D2/HLA-A/HLA-C/ATP6V1A/ATP6V1C1/SPP1/ITGAV/ATP6V0C/ATP6V1F/NFKB1/ATP6AP1/ATP6V1B2/ATP6V1H/TCIRG1/ATP6V1G1/HLA-F/HLA-E/MAML3/VEGFA/ITGB5/ATP6V0B/ITGA2	3.21518772134656
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/343	201/9376	2.17594244520836	MMP9/SUPT3H/MITF/BMP2K/CSF1R/NFKB1/NR4A3/JMJD1C/DUSP6/BIRC3/RUNX1/SPI1/AFF1/ID2/PBX3/GZMB	3.28395919174167
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	21/343	300/9376	1.9134693877551	HSPA1A/MAP4K4/RAC2/HSPA1B/NFATC1/DUSP1/CSF1R/NFKB1/DUSP6/DUSP2/MAP3K2/RPS6KA2/NR4A1/HSPA8/RASA2/TAB2/ARRB1/VEGFA/RAP1A/RASGRP3/MAPK8	3.13345941973344
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/343	54/9376	3.54346182917611	HLA-B/HLA-A/HLA-C/HLA-DRA/HLA-F/HLA-E/GZMB	3.65244973670197
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/343	69/9376	3.16930747454261	RAC2/ALOX5AP/INPP5D/FCER1G/LCP2/SYK/MAPK8/LAT	3.52417522828348
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/343	137/9376	2.39433082930774	CTSK/CTSS/NFKB1/NFKBIA/CTSD/BIRC3/CFLAR/MCL1/ERN1/ITPR2/GZMB/MAPK8	3.20354126884452
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/343	268/9376	1.9379487402637	NFE2L2/DUSP1/ATF6/MT-ND2/SLC25A6/ERN1/MT-ND5/MT-ND4/MT-ATP6/MT-CO2/NDUFB5/UQCRB/CAMK2D/ITPR2/MT-ND1/MAPK8/MT-CO1/PPIF/MT-CO3	3.03564990314758
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	12/343	138/9376	2.37698060590696	RAC2/NFATC1/NFKB1/NFKBIA/SKAP2/PYCARD/LCP2/RPS6KA2/TAB2/MAPK8/BAIAP2/LAT	3.1753754357978
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	10/343	105/9376	2.60335971123143	NFATC1/NFKB1/NFKBIA/PYCARD/CLEC4E/FCER1G/SYK/CLEC7A/ITPR2/MAPK8	3.21943023719222
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/343	93/9376	2.64534938399323	NFATC1/HLA-DRA/NFKB1/NFKBIA/NFKBIE/MAML3/RUNX3/MAPK8/LAT	3.10722086908126
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/343	94/9376	2.6172073692699	MMP9/NFKB1/CXCL3/NFKBIA/HSP90AA1/TNFAIP3/TAB2/USP25/MAPK8	3.07061628957998
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/343	149/9376	2.20149881620913	DGKI/GNA13/DNM1/RALA/FCER1G/PIK3R5/CYTH4/SYK/AGPAT3/CYTH1/PIK3CG/AGPAT4	2.88073238032649
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	17/343	248/9376	1.8737891469952	PTPRC/NCKAP1L/LY96/ABI1/NFKB1/NFKBIA/BIRC3/HSP90AA1/RALA/PYCARD/SNX9/CYTH4/S100A10/TAB2/MAPK8/CYTH1/PIK3CG	2.71744876124849
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	10/343	120/9376	2.2779397473275	MATK/NFKB1/NFKBIA/IRAK3/RPS6KA2/NFKBIE/CAMK2D/KIDINS220/RAP1A/MAPK8	2.74540247724147
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	16/343	238/9376	1.8376656785163	RAC2/GNG2/ABL2/GNB4/CSF1R/NFKB1/RALA/RALGAPA1/RASA3/RASA2/VEGFA/TIAM1/RAP1A/RASGRP3/MAPK8/LAT	2.55064675506188
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	11/343	142/9376	2.11752145526219	MMP9/NFE2L2/RAC2/MEF2A/DUSP1/ITGAV/NFKB1/CYBA/HSP90AA1/VEGFA/MAPK8	2.61469959778905
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/343	200/9376	1.9134693877551	MYO5A/NCKAP1L/ABI1/MYO1D/NFKB1/GNA13/NFKBIA/PYCARD/MYO1F/CYTH4/TAB2/MAPK8/CYTH1/BAIAP2	2.54447967609891
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/343	91/9376	2.40310127190594	RAC2/NFATC1/NFKB1/NFKBIA/INPP5D/SYK/NFKBIE/RASGRP3	2.62080949525465
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/343	109/9376	2.25704121753551	CTSK/LY96/SPP1/NFKB1/NFKBIA/CCL3/CCL4/TAB2/MAPK8	2.57223047141701
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/343	168/9376	1.95251978342357	GLUD1/FTL/BIRC3/HSP90AA1/GLUL/CFLAR/PYCARD/TNFAIP3/SLC25A6/CAMK2D/CHMP1B/MAPK8	2.42751925390502
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/343	212/9376	1.80515979976896	RAC2/DOCK4/CSF1R/RALA/LCP2/SIPA1L1/VEGFA/ITGB2/TIAM1/RAP1A/RASGRP3/APBB1IP/LAT/SIPA1L2	2.31059679445086
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/343	157/9376	1.91521048819892	HLA-B/HLA-A/HLA-C/NFATC1/NFKB1/ZFP36L2/HLA-F/SLC25A6/HLA-E/ITPR2/FBXW11	2.25343793076391
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/343	119/9376	2.06737388833084	MMP9/NFKB1/CXCL3/NFKBIA/BIRC3/CFLAR/TNFAIP3/TAB2/MAPK8	2.28334542268
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/343	83/9376	2.30538480452422	NFKB1/IFI16/NFKBIA/PYCARD/CCL4/G3BP1/SAMHD1	2.32764274309595
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/343	122/9376	2.01653682550304	PTPRC/NFATC1/NFKB1/NFKBIA/TEC1/LCP2/NFKBIE/MAPK8/LAT	2.2021909677799
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	14/343	224/9376	1.70845481049563	HLA-B/HLA-A/HLA-C/NFATC1/HLA-DRA/NFKB1/NFKBIA/ZFP36/HLA-F/SLC25A6/HLA-E/SPI1/ITGB2/MAPK8	2.09119653244169
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/343	205/9376	1.7334565882102	HLA-B/ATP6V0D2/HLA-A/HLA-C/HDAC9/NFKB1/NFKBIA/GSN/SYK/HLA-F/HLA-E/SP100/RASA2	2.06899618964815
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/343	87/9376	2.19939010086793	ATP1B3/ATP1B1/SLC9A7/MT-CO2/UQCRB/MT-CO1/MT-CO3	2.19004126556728
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/343	166/9376	1.81137377498332	ATP1B3/MEF2A/NFATC1/GNA13/ATP1B1/PIK3R5/SLC25A6/ITPR2/ATP2B1/PIK3CG/PPIF	2.05523689884623
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/343	232/9376	1.64954257565095	NCKAP1L/RAC2/RGCC/ITGAV/GNA13/GSN/CXCR4/IQGAP2/PIP4K2A/ITGB2/TIAM1/ITGB5/BAIAP2/ITGA2	1.95209163281374
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/343	109/9376	2.00625886003156	NFKB1/NFKBIA/TBC1D4/RPS6KA2/PTPN1/PPARGC1B/MAPK8/MLX	2.05906510128687
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/343	130/9376	1.89244225162593	MMP9/GNG2/GNA15/GNB4/NFKB1/NFKBIA/ARRB1/VEGFA/MAPK8	1.99660221219118
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/343	10/9376	5.46705539358601	PAPSS2/SQOR	2.75398109292667
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/343	23/9376	3.56547090886044	ATP1B3/GLUD1/ATP1B1	2.40033710317297
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/343	73/9376	2.24673509325452	BST2/MDFIC/RANBP2/CXCR4/ELL2/SAMHD1	2.08372689326555
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/343	93/9376	2.05749396532807	PTPRJ/RAC2/PTPRM/PTPN1/SMURF2/RAP1A/BAIAP2	1.99706357200568
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/343	157/9376	1.7411004438172	NFATC1/ITGAV/C1QB/DUSP2/HIF1A/CAMK2D/ATP11B/SGK1/ITGB5/PROS1	1.8247429112074
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/343	157/9376	1.7411004438172	NFKB1/ERN1/MT-CO2/NDUFB5/UQCRB/IL6R/MAPK8/MLX/MT-CO1/MT-CO3	1.8247429112074
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	10/343	158/9376	1.73008082075507	ATP6V1A/STRADB/ATP6V1C1/ATP6V1F/ATP6V1B2/ATP6V1H/RPS6KA2/ATP6V1G1/CAB39/SGK1	1.80342391434637
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/343	78/9376	2.10271361291769	LY96/NFKB1/C1QB/PYCARD/ITGB2/MAPK8	1.90560094482044
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/343	78/9376	2.10271361291769	HLA-DRA/NFKB1/CYBA/NFKBIA/TAB2/ITGB2	1.90560094482044
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/343	98/9376	1.95251978342357	ATP1B3/ATP1B1/NR4A2/NR4A1/CAMK2D/ITPR2/ATP2B1	1.84704106608421
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	12/343	204/9376	1.60795746870177	MMP9/LUM/ITGAV/CD44/DCN/HIF1A/CAMK2D/ITPR2/VEGFA/TIAM1/ITGB5/ITGA2	1.71069644111222
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/343	226/9376	1.57238318842075	RAC2/ATP1B3/NFATC1/NFKB1/ATP1B1/NFKBIA/CAMK2D/PDE4B/SUCNR1/ATP2B1/TIAM1/RAP1A/MAPK8	1.69725554095972
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	19/343	362/9376	1.43472448174218	PRL/GNG2/GNB4/SPP1/CSF1R/ITGAV/SGK3/NFKB1/HSP90AA1/MCL1/PIK3R5/SYK/NR4A1/IL6R/VEGFA/SGK1/ITGB5/PIK3CG/ITGA2	1.64371417305987
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/343	100/9376	1.9134693877551	CSF1R/TNFRSF14/CXCL3/CCL3/CCL4/CXCR4/IL6R	1.78949430643357
NA	NA	hsa04517	IgSF CAM signaling	16/343	299/9376	1.46275729594274	CADM1/SRGAP1/CD84/MBP/MTSS1/EPB41L2/NRP2/INPP5D/LCP2/PLXNA2/NCAM1/ITGB2/RAP1A/MAPK8/DOK2/BAIAP2	1.58465379197671
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/343	103/9376	1.85773726966515	GNA15/NFKB1/C1QB/NFKBIA/CFLAR/CCL3/MAPK8	1.70560891221717
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/343	65/9376	2.10271361291769	DGKI/GLA/GK/AGPAT3/AGPAT4	1.73835289044212
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	13/343	235/9376	1.51216425780038	ARID1B/MT-ND2/RPS6KA2/MT-ND5/MT-ND4/MT-ATP6/MT-CO2/NDUFB5/UQCRB/MT-ND1/ATP5ME/MT-CO1/MT-CO3	1.54939816408627
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/343	30/9376	2.733527696793	NFKB1/ABCC3/ABCC5	1.85308447227022
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	9/343	149/9376	1.65112411215685	GNG2/GNB4/MT-ND2/MT-ND5/MT-ND4/NDUFB5/ITPR2/MT-ND1/MAPK8	1.56114536959734
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/343	68/9376	2.00994683587721	CSF1R/NFKB1/DUSP6/RUNX1/SPI1	1.62870142011196
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	10/343	174/9376	1.57099292919138	NFE2L2/HSPA1A/HSPA1B/ATF6/HSP90AA1/HSPH1/DNAJB1/ERN1/HSPA8/MAPK8	1.481429310492
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/343	90/9376	1.822351797862	NFATC1/NFKB1/NFKBIA/HIF1A/NFKBIE/LAT	1.52750012478279
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/343	16/9376	3.41690962099125	GLA/GBGT1	1.88538119285336
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	19/343	388/9376	1.33858315049142	APOE/NFKB1/ATF6/DKK1/MT-ND2/SLC25A6/ERN1/MT-ND5/MT-ND4/MT-ATP6/MT-CO2/NDUFB5/UQCRB/ITPR2/MT-ND1/MAPK8/MT-CO1/PPIF/MT-CO3	1.32729166077734
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/343	93/9376	1.76356625599549	CST3/ATP1B3/ATP1B1/LYZ/ITPR2/ATP2B1	1.44198492346789
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/343	93/9376	1.76356625599549	FHIT/ITGAV/NFKB1/NFKBIA/BIRC3/ITGA2	1.44198492346789
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/343	136/9376	1.60795746870177	HSPA1A/HSPA1B/NFKB1/NFKBIA/TNFAIP3/HSPA8/TAB2/MAPK8	1.39162864558196
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/343	17/9376	3.21591493740353	GLUD1/GLUL	1.78188435699249
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/343	53/9376	2.06303977116453	ATP1B3/ATP1B1/DNM1/ATP2B1	1.51225942102586
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/343	115/9376	1.66388642413487	MEF2A/GNA13/NR4A2/ARRB1/ITPR2/PDE4B/SGK1	1.39582334955253
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/343	139/9376	1.57325335067223	MMP9/HSPA1A/FKBP5/HSPA1B/CTSD/HSP90AA1/HSPA8/ITPR2	1.32679926812373
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/343	18/9376	3.03725299643667	MAN2B1/MANBA	1.68580132355995
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/343	140/9376	1.56201582673886	GNG2/MEF2A/GNB4/SPP1/GNA13/PIK3R5/ITPR2/PIK3CG	1.30553131841965
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/343	98/9376	1.67358838579163	PTPRC/RAC2/GSN/INPP5D/SYK/LAT	1.30616227803981
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/343	77/9376	1.77501798493052	RAC2/NFKB1/RALA/VEGFA/MAPK8	1.33062510367352
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/343	19/9376	2.87739757557158	GNS/IDS	1.59617840748229
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/343	99/9376	1.65668345260182	GPCPD1/RAC2/DGKI/HIF1A/SLC44A1/MAPK8	1.2799310800371
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/343	144/9376	1.51862649821834	LY96/NFKB1/CXCL3/C1QB/NFKBIA/SCD5/TAB2/MAPK8	1.22209437086656
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/343	122/9376	1.56841753094681	SLC16A10/ATP1B3/ITGAV/THRB/ATP1B1/TBC1D4/HIF1A	1.23140049742848
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/343	100/9376	1.6401166180758	ANPEP/HLA-DRA/CSF1R/CD44/IL6R/ITGA2	1.25399390374236
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/343	38/9376	2.15804818167869	ATP1B3/ATP1B1/SGK1	1.39382479376954
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/343	195/9376	1.40180907527846	RAC2/HDAC9/NFKB1/CYBA/SYK/SELPLG/SLC25A6/CLEC7A/ITGB2/PPIF	1.10486380539546
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/343	104/9376	1.57703520968827	GPCPD1/DGKI/PLD3/MBOAT7/AGPAT3/AGPAT4	1.15305219040666
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/343	61/9376	1.79247717822492	ATP1B3/FTL/ATP1B1/ATP2B1	1.20997652689274
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/343	41/9376	2.00014221716561	MMP9/VEGFA/DAPK1	1.25058501376762
NA	NA	hsa04518	Integrin signaling	8/343	154/9376	1.42001438794442	RAC2/SPP1/ITGAV/FERMT3/VEGFA/ITGB2/ITGB5/ITGA2	1.02406768592593
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/343	23/9376	2.37698060590696	GLUD1/GLUL	1.28834734679421
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/343	23/9376	2.37698060590696	ANPEP/ATP6AP2	1.28834734679421
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	12/343	253/9376	1.29653487594925	NFKB1/NFKBIA/CD44/PYCARD/CAST/CYTH4/TAB2/FNBP1/ITPR2/FBXW11/MAPK8/CYTH1	0.931716732684401
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/343	89/9376	1.53568971729944	SPP1/ITGAV/CD44/ITGB5/ITGA2	0.989435033719161
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	21/343	480/9376	1.19591836734694	NFKB1/ATF6/ATXN1/TANK/DKK1/MT-ND2/SLC25A6/ERN1/MT-ND5/MT-ND4/MT-ATP6/MT-CO2/NDUFB5/UQCRB/CAMK2D/ITPR2/MT-ND1/MAPK8/MT-CO1/PPIF/MT-CO3	0.858647831953192
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/343	67/9376	1.63195683390627	RPS6KA2/CAMK2D/ITPR2/RAP1A	1.01155614789002
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/343	184/9376	1.33705159082266	SRGAP1/RAC2/CXCR4/PLXNA2/SEMA4D/CAMK2D/DPYSL2/SEMA4A/SEMA3B	0.899739895538959
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/343	308/9376	1.24251258945136	MT-ND2/SLC25A6/ERN1/MT-ND5/MT-ND4/MT-ATP6/MT-CO2/NDUFB5/UQCRB/MT-ND1/MAPK8/MT-CO1/PPIF/MT-CO3	0.843277639196121
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/343	91/9376	1.50193829494121	GNG2/GNB4/PDE7A/ARRB1/PDE4B	0.937555025965398
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/343	115/9376	1.42618836354418	GNG2/GNB4/PIK3R5/CAMK2D/ITPR2/PIK3CG	0.896062409948737
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/343	116/9376	1.41389363627224	MMP9/RAC2/CYBA/CXCR4/ITGB2/RAP1A	0.874035240481792
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/343	70/9376	1.56201582673886	NFKB1/NFKBIA/NFKBIE/MAPK8	0.919671513924943
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	11/343	238/9376	1.26339515397996	NFKB1/C1QB/NFKBIA/SYK/F13A1/TAB2/IL6R/RPL36A/RPS9/MAPK8/RPL23	0.802024019878631
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/343	71/9376	1.54001560382704	PRL/TNFRSF11A/NFKB1/MAPK8	0.890008158489836
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/343	72/9376	1.51862649821834	NFKB1/NFKBIA/TANK/MAPK8	0.860801059563938
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	7/343	144/9376	1.32879818594104	ATXN1/SLC25A6/ERN1/PUM2/ITPR2/MAPK8/PPIF	0.774781877844824
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/343	76/9376	1.43869878778579	ATP1B3/ATP1B1/CAMK2D/ITPR2	0.748252969989055
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/343	125/9376	1.31209329446064	RAC2/NFKB1/GNA13/CTSD/FCER1G/MAPK8	0.684481629487135
NA	NA	hsa04981	Folate transport and metabolism	2/343	31/9376	1.76356625599549	ABCC3/ABCC5	0.829764049710229
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/343	102/9376	1.33996455725147	ATP1B3/ATP1B1/ITPR2/ATP2B1/RAP1A	0.67269294903819
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	9/343	203/9376	1.21190883109049	RAC2/SPP1/ITGAV/BIRC3/VEGFA/RAP1A/ITGB5/MAPK8/ITGA2	0.594782348238905
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/343	55/9376	1.49101510734164	GLA/PSAP/ACER3	0.711642109506327
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	8/343	178/9376	1.22855177383955	RAC2/NFATC1/DKK1/CTNNBIP1/CAMK2D/FBXW11/MAPK8/BAMBI	0.599880283343353
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/343	32/9376	1.70845481049563	BIRC3/MAPK8	0.782235318792301
Human Diseases	Immune disease	hsa05310	Asthma	2/343	32/9376	1.70845481049563	HLA-DRA/FCER1G	0.782235318792301
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/343	56/9376	1.46438983756768	ARRB1/SMURF2/FBXW11	0.679180890034845
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/343	105/9376	1.30167985561572	MITF/HIF1A/SMURF2/MAPK8/ARIH1	0.60575131227108
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/343	133/9376	1.23317038953068	GNG2/GNB4/ARRB1/CAMK2D/ITPR2/MAPK8	0.527727146821233
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/343	12/9376	2.2779397473275	NCAM1	0.863151424641772
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/343	83/9376	1.31736274544241	L3MBTL4/FOXK2/SFMBT2/JARID2	0.565892209559829
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	15/343	368/9376	1.11420965901889	ATF6/TANK/RANBP2/MT-ND2/NUP98/ERN1/MT-ND5/MT-ND4/MT-ATP6/MT-CO2/NDUFB5/UQCRB/MT-ND1/MT-CO1/MT-CO3	0.435541205268315
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/343	110/9376	1.24251258945136	NFKB1/HIF1A/CAMK2D/IL6R/VEGFA	0.498541339939558
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/343	110/9376	1.24251258945136	EMP3/DCN/ID2/SMURF2/BAMBI	0.498541339939558
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/343	110/9376	1.24251258945136	CPEB4/HSP90AA1/CPEB3/RPS6KA2/MAPK8	0.498541339939558
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/343	86/9376	1.27140823106651	ITGAV/ACTN2/ITGB5/ITGA2	0.49269831408964
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/343	163/9376	1.17390759984976	MMP9/NFATC1/NFKB1/ATP6AP1/NFKBIA/TAB2/MAPK8	0.436443993578897
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/343	138/9376	1.18849030295348	CPEB4/CPEB3/RPS6KA2/CAMK2D/ITPR2/FBXW11	0.434666599745129
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/343	37/9376	1.47758253880703	GLUD1/GLUL	0.567173338312937
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/343	62/9376	1.32267469199661	HSPA1A/HSPA1B/HSPA8	0.496717344696756
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/343	88/9376	1.24251258945136	C1QB/F13A1/ITGB2/PROS1	0.445380516602543
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/343	169/9376	1.13223040695568	TANK/CTSD/CFLAR/ERN1/HIF1A/MAPK8/DAPK1	0.338012147587098
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/343	65/9376	1.26162816775062	SPP1/ARRB1/ITPR2	0.412438983524462
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/343	15/9376	1.822351797862	ST6GALNAC3	0.621096162956288
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/343	15/9376	1.822351797862	AK5	0.621096162956288
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/343	66/9376	1.24251258945136	NFATC1/HLA-DRA/NFKB1	0.385254845087848
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/343	93/9376	1.17571083733032	MAP3K2/CAMK2D/ITPR2/MAPK8	0.331827626392312
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/343	173/9376	1.1060516692226	HLA-DRA/NFKB1/NFKBIA/PYCARD/DNAJB1/NUP98/SLC25A6	0.274342152768666
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/343	254/9376	1.07619200661142	GNA15/NFATC1/CYSLTR1/SLC25A6/CXCR4/CAMK2D/ITPR2/VEGFA/ATP2B1/PPIF	0.239882147913864
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/343	17/9376	1.60795746870177	HSD3B7	0.488877025426699
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/343	17/9376	1.60795746870177	PAPSS2	0.488877025426699
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/343	17/9376	1.60795746870177	NRP2	0.488877025426699
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/343	70/9376	1.17151187005414	HIF1A/VEGFA/RAP1A	0.280658610815393
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/343	98/9376	1.11572559052776	DGKI/INPP5D/PIP4K2A/ITPR2	0.224404701951014
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/343	99/9376	1.10445563506788	PRKCH/CAMK2D/ITPR2/MAPK8	0.203592786263581
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/343	99/9376	1.10445563506788	HLA-DRA/C1QB/SELPLG/ITGB2	0.203592786263581
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/343	45/9376	1.21490119857467	ABCC3/ABCC5	0.281577334197347
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/343	154/9376	1.06501079095831	ATP1B3/ATP1B1/PIK3R5/CAMK2D/ATP2B1/PIK3CG	0.15850754680743
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/343	128/9376	1.06778425655977	PAPSS2/FHIT/AK5/PDE7A/PDE4B	0.150461921784977
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/343	46/9376	1.18849030295348	FTL/BLVRA	0.249714522178404
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/343	101/9376	1.08258522645267	NFATC1/NFKB1/VEGFA/MAPK8	0.162600839997266
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/343	157/9376	1.04466026629032	BIRC3/WWC1/ID2/TP53BP2/ITGB2/FBXW11	0.109962832981378
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/343	75/9376	1.0934110787172	GLUL/MAT2A/TKT	0.158263545207658
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/343	75/9376	1.0934110787172	ATP1B3/ATP1B1/ITPR2	0.158263545207658
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/343	103/9376	1.06156415409437	SLC16A10/ATP1B3/ATP1B1/COL18A1	0.122420202094589
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/343	103/9376	1.06156415409437	GNA15/NFKB1/CXCL3/ITGB2	0.122420202094589
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/343	48/9376	1.13896987366375	ATP1B3/ATP1B1	0.188089133529945
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/343	76/9376	1.07902409083934	APOA1/GK/SCD5	0.134784987598588
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/343	298/9376	1.00902029076252	PRL/TNFRSF11A/IL13RA1/CSF1R/TNFRSF14/CXCL3/IL1RL1/CCL3/CCL4/CXCR4/IL6R	0.0308354487325561
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/343	77/9376	1.06501079095831	NFKB1/NFKBIA/RUNX1	0.111616752308732
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/343	21/9376	1.30167985561572	UST	0.269681252223792
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/343	21/9376	1.30167985561572	DPYD	0.269681252223792
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/343	106/9376	1.03151988558227	MMP9/NFKB1/NFKBIA/HSP90AA1	0.0635937435201331
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/343	78/9376	1.05135680645885	INPP5D/PIP4K2A/PIK3CG	0.0887497694455724
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/343	78/9376	1.05135680645885	HSPD1/ZCCHC7/BTG2	0.0887497694455724
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/343	50/9376	1.0934110787172	HLA-DRA/CXCR4	0.12904832653033
NA	NA	hsa04081	Hormone signaling	8/343	219/9376	0.998548930335343	PRL/SLC16A10/GNG2/GNA15/GNB4/ITGAV/GNA13/THRB	-0.00423399564024349
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/343	22/9376	1.24251258945136	HNMT	0.221903238059077
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/343	52/9376	1.05135680645885	APOA1/APOE	0.0723627799091131
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/343	24/9376	1.13896987366375	EXT1	0.132828334626282
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/343	115/9376	0.950792242362784	GNG2/GNB4/DUSP1/ITPR2	-0.103459469258848
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/343	86/9376	0.953556173299885	ABL2/CAMK2D/MAPK8	-0.0843113527732709
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/343	86/9376	0.953556173299885	ATP1B3/ATP1B1/CAMK2D	-0.0843113527732709
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/343	116/9376	0.942595757514829	GNG2/GNB4/GLUL/ITPR2	-0.12122276471098
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/343	26/9376	1.05135680645885	APOA1	0.0510970198835966
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/343	87/9376	0.942595757514829	RAC2/RALA/MAPK8	-0.104817990218679
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/343	233/9376	0.938550282160688	ATP1B3/ITGAV/VIM/ATP1B1/DCN/ACTN2/ITGB5/ITGA2	-0.185084558276504
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/343	27/9376	1.01241766547889	SCD5	0.0125908761333658
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/343	89/9376	0.921413830379664	GNG2/GNB4/GLUL	-0.145151020968157
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/343	90/9376	0.911175898931001	ATP1B3/ATP1B1/ABCC3	-0.164988786817711
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/343	28/9376	0.976259891711787	GCNT2	-0.0245142749349268
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/343	28/9376	0.976259891711787	PCBD1	-0.0245142749349268
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/343	60/9376	0.911175898931001	RAC2/VEGFA	-0.134495699915788
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/343	60/9376	0.911175898931001	GNA13/ITPR2	-0.134495699915788
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/343	29/9376	0.942595757514829	WWC1	-0.0603286436075544
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/343	62/9376	0.881783127997743	ATXN1/MAML3	-0.181980093932912
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/343	154/9376	0.88750899246526	NFATC1/PIK3R5/CAMK2D/ITPR2/PIK3CG	-0.27427252275182
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/343	155/9376	0.881783127997743	AHR/NR4A1/CAMK2D/ITPR2/RAP1A	-0.289183157266756
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/343	31/9376	0.881783127997743	TKT	-0.128465748304688
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/343	31/9376	0.881783127997743	DPYD	-0.128465748304688
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/343	31/9376	0.881783127997743	GLUL	-0.128465748304688
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/343	65/9376	0.841085445167078	NR4A1/ITPR2	-0.250517969934368
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/343	97/9376	0.845420937152475	GNG2/GNB4/CAMK2D	-0.29819656945523
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/343	32/9376	0.854227405247813	GLA	-0.160953769298827
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/343	99/9376	0.82834172630091	ITGAV/ITGB5/ITGA2	-0.334576360623179
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/343	34/9376	0.803978734350883	FBXW11	-0.223120466419453
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/343	36/9376	0.759313249109168	GBE1	-0.281933504430669
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/343	36/9376	0.759313249109168	ST6GALNAC3	-0.281933504430669
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/343	105/9376	0.781007913369429	ITGAV/ITGB5/ITGA2	-0.439720257697377
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/343	37/9376	0.738791269403514	APOA1	-0.310209473107966
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/343	170/9376	0.803978734350883	RUNX1/YBX3/TIAM1/RAP1A/MAPK8	-0.502584230272343
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/343	107/9376	0.766409634614861	SIK2/CAMK2D/ITPR2	-0.473529529388027
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/343	38/9376	0.719349393892895	NAMPT	-0.337790585372264
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/343	38/9376	0.719349393892895	PTPRC	-0.337790585372264
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/343	75/9376	0.728940719144801	MDM4/SESN1	-0.459247482618811
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/343	39/9376	0.700904537639232	MAT2A	-0.364716273269528
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/343	142/9376	0.770007801913522	BIRC3/UBE2W/SMURF2/FBXW11	-0.538119876803838
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/343	41/9376	0.666714072388537	BABAM2	-0.416743118345454
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/343	78/9376	0.700904537639232	ARHGAP10/DNM1	-0.516867289012716
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/343	42/9376	0.650839927807858	FTL	-0.441908153485541
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/343	80/9376	0.683381924198251	IL6R/VEGFA	-0.554178068027506
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/343	43/9376	0.635704115533256	APOA1	-0.466546088770371
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/343	44/9376	0.621256294725682	B4GALNT3	-0.490683088152859
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/343	44/9376	0.621256294725682	CCNH	-0.490683088152859
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/343	117/9376	0.700904537639232	ARID1B/PBRM1/BAZ2B	-0.634362360150663
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/343	217/9376	0.755814109712351	NFKB1/HSP90AA1/AHR/RPS6KA2/ARRB1/VEGFA	-0.709158146359853
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/343	47/9376	0.581601637615533	MAPK8	-0.560322486398851
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/343	122/9376	0.672178941834345	STRADB/SCD5/CAB39	-0.710180443274358
NA	NA	hsa03272	Virion - Hepatitis viruses	1/343	48/9376	0.569484936831876	CHMP1B	-0.582681721355005
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/343	49/9376	0.557862795263878	NFKB1	-0.60464547345648
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/343	323/9376	0.761664064121889	MMP9/NFKB1/ZEB2/VIM/CD44/MCL1/VEGFA/FOXP1/MDM4	-0.84939797941262
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/343	89/9376	0.614275886919776	MAP3K2/ITPR2	-0.712444048311815
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/343	194/9376	0.704517447627063	MYO5A/MYO1D/KIF13B/KIF1B/MYO1F	-0.810365149740244
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/343	50/9376	0.546705539358601	CKB	-0.626230768069156
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/343	50/9376	0.546705539358601	ITGB2	-0.626230768069156
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/343	90/9376	0.607450599287334	NFKB1/SESN1	-0.729151757351211
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/343	51/9376	0.535985822900589	PLD3	-0.647453541478122
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/343	54/9376	0.506208832739445	MAT2A	-0.709091600337002
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	4/343	168/9376	0.650839927807858	PRL/IL13RA1/MCL1/IL6R	-0.889842723155681
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/343	133/9376	0.616585194765339	SGK3/SGK1/MAPK8	-0.867770567363936
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/343	134/9376	0.611983812714851	GNA13/PRKCH/ITPR2	-0.881527680777423
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/343	57/9376	0.479566262595264	SCD5	-0.767953470283739
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/343	99/9376	0.55222781753394	MMP9/MAPK8	-0.872745507509939
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/343	138/9376	0.59424515147674	PTPN1/PRKAR2B/MAPK8	-0.935687818281209
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/343	101/9376	0.541292613226337	MITF/CAMK2D	-0.90314223991491
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/343	59/9376	0.463309779117458	DPYD	-0.805801985564773
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/343	59/9376	0.463309779117458	ANPEP	-0.805801985564773
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/343	63/9376	0.433893285205239	SETDB2	-0.878497384012499
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/343	63/9376	0.433893285205239	TBXAS1	-0.878497384012499
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/343	63/9376	0.433893285205239	CCNH	-0.878497384012499
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/343	108/9376	0.506208832739445	RANBP2/NUP98	-1.00572414235242
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/343	66/9376	0.414170863150455	HSD17B11	-0.9306465857113
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/343	69/9376	0.396163434317827	ITPR2	-0.980970144473214
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/343	69/9376	0.396163434317827	CAMK2D	-0.980970144473214
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/343	156/9376	0.525678403229424	NFKB1/NFKBIA/CFLAR	-1.16408965859787
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/343	116/9376	0.471297878757414	GLUD1/TKT	-1.11648076990375
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/343	71/9376	0.385003900956761	HIF1A	-1.0135846847922
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/343	73/9376	0.374455848875754	MITF	-1.04550130791614
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/343	73/9376	0.374455848875754	FHIT	-1.04550130791614
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/343	75/9376	0.3644703595724	BIRC3	-1.07675851044528
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/343	122/9376	0.44811929455623	ITPR2/MAPK8	-1.19557567845007
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/343	76/9376	0.359674696946448	CAMK2D	-1.09215097718235
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/343	243/9376	0.562454258599383	HSPA1A/HSPA1B/HSPA8/HNRNPU/RP9	-1.34659365045388
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	3/343	170/9376	0.48238724061053	NFE2L2/ARID1B/PBRM1	-1.32712136816097
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/343	82/9376	0.333357036194269	DPYD	-1.18145064807506
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/343	85/9376	0.321591493740353	AK5	-1.22429537996487
NA	NA	hsa04519	Cadherin signaling	9/343	404/9376	0.608954189879629	NCKAP1L/RAC2/MYO1D/NFKB1/VIM/NFKBIA/MYO1F/WWC1/MAPK8	-1.56563449064449
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/343	143/9376	0.382311565985035	HLA-DRA/C1QB	-1.45038320951448
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/343	144/9376	0.379656624554584	ID2/JARID2	-1.46178058726388
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/343	191/9376	0.429349900019843	GNG2/GNB4/HDAC9	-1.55261470141863
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/343	154/9376	0.355003596986104	AK5/MAT2A	-1.57261273142957
Genetic Information Processing	Translation	hsa03010	Ribosome	3/343	222/9376	0.369395634701757	RPL36A/RPS9/RPL23	-1.8528689308469
NA	NA	hsa04082	Neuroactive ligand signaling	2/343	199/9376	0.274726401687739	GNG2/GNB4	-2.01509132720455
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/343	158/9376	0.173008082075506	CCNH	-2.04281082225081
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/343	370/9376	0.295516507761406	PRL/THRB/CYSLTR1/NR3C1	-2.69415392615962
NA	NA	hsa04382	Cornified envelope formation	1/343	217/9376	0.125969018285392	S100A10	-2.53833745317415
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/343	449/9376	0.121760699188998	ARRB1/CAMK2D	-3.71620757208557