category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/76	45/9376	19.1906432748538	HLA-DRB1/KLRC1/HLA-DMA/HLA-DPA1/GZMB/CD86/TNF	11.0570985272373
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/76	82/9376	12.0359435173299	B2M/HSPA1B/HLA-DRB1/KLRC1/HLA-DMA/HLA-DPA1/CD74/TNF	9.0733156816337
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/76	160/9376	7.71052631578947	HLA-DRB1/ICAM1/HLA-DMA/HLA-DPA1/CADM1/NCAM1/PTPRC/CDH2/CD86/NEGR1	7.73920413649774
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/76	39/9376	18.9797570850202	HLA-DRB1/HLA-DMA/HLA-DPA1/GZMB/CD86/TNF	10.1709941398308
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/76	44/9376	16.822966507177	HLA-DRB1/HLA-DMA/HLA-DPA1/GZMB/CD86/TNF	9.50994142656831
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/76	180/9376	6.85380116959064	B2M/HLA-DRB1/HLA-DMA/HLA-DPA1/BST2/CD74/SP100/TNF/OAS2/BIRC3	7.16845723001602
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	10/76	205/9376	6.01797175866496	B2M/HLA-DRB1/ISG15/ICAM1/HLA-DMA/HLA-DPA1/TNFAIP3/GADD45B/TNF/OAS2	6.56670877967494
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	9/76	173/9376	6.41801034377852	MX1/HLA-DRB1/ICAM1/HLA-DMA/HLA-DPA1/PYCARD/TNF/DNAJB1/OAS2	6.50203241743597
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/76	133/9376	7.42065690542145	CD48/KLRC1/ICAM1/LCP2/GZMB/VAV3/TNF/TYROBP	6.74139489114275
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/76	112/9376	7.71052631578947	HSPA1B/HLA-DRB1/HLA-DMA/HLA-DPA1/GNAI2/TNF/BIRC3	6.45828612692348
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/76	54/9376	11.4230019493177	HLA-DRB1/HLA-DMA/HLA-DPA1/GZMB/CD86	6.94362262626641
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/76	95/9376	7.79168975069252	HLA-DRB1/ICAM1/HLA-DMA/HLA-DPA1/CD86/TNF	6.01441255804788
Human Diseases	Immune disease	hsa05310	Asthma	4/76	32/9376	15.4210526315789	HLA-DRB1/HLA-DMA/HLA-DPA1/TNF	7.38680264809224
NA	NA	hsa04517	IgSF CAM signaling	10/76	299/9376	4.12603414891744	CD48/CD84/ICAM1/LCP2/CADM1/NCAM1/CDH2/VAV3/ACTR2/CD86	4.96602732020295
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/76	100/9376	7.40210526315789	HLA-DRB1/HLA-DMA/HLA-DPA1/TNF/IL1R2/CD37	5.81826369732991
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/76	105/9376	7.04962406015038	ICAM1/BCL2A1/TNFAIP3/GADD45B/TNF/BIRC3	5.63521780298443
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/76	201/9376	4.91018591254255	MMP9/BCL2A1/MEF2C/GADD45B/GZMB/CD86/IL1R2/BIRC3	5.06574540348441
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/76	70/9376	8.81203007518797	HLA-DRB1/ICAM1/HLA-DMA/HLA-DPA1/CD86	5.93037781637972
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/76	216/9376	4.56920077972709	MMP9/APOA1/HSPA1B/ICAM1/PYCARD/VAV3/TNF/CAMK2D	4.79734639420342
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/76	224/9376	4.40601503759398	B2M/HLA-DRB1/ICAM1/HLA-DMA/ZFP36/HLA-DPA1/TNF/IL1R2	4.66405351188367
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/76	181/9376	4.77115440535039	CLEC7A/HLA-DRB1/HLA-DMA/HLA-DPA1/CD74/TNF/CAMK2D	4.63114837271829
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/76	50/9376	9.86947368421053	HLA-DRB1/HLA-DMA/HLA-DPA1/CD86	5.6844193112501
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/76	142/9376	5.21275018532246	MMP9/ICAM1/MEF2C/MEF2A/TNF/IL1R2	4.57262833845777
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/76	66/9376	7.47687400318979	HLA-DRB1/HLA-DMA/HLA-DPA1/TNF	4.77324290844213
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/76	119/9376	5.18354710305175	MMP9/ICAM1/TNFAIP3/TNF/BIRC3	4.15177655403204
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/76	37/9376	10.0028449502134	APOA1/ICAM1/TNF	4.95999689993577
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/76	78/9376	6.32658569500675	HLA-DRB1/HLA-DMA/HLA-DPA1/TNF	4.27024122482486
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	5/76	137/9376	4.50249711870918	BCL2A1/GADD45B/GZMB/TNF/BIRC3	3.73315950975084
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/76	138/9376	4.4698703279939	LCP2/PYCARD/VAV3/ACTR2/TNF	3.71205813764142
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/76	143/9376	4.31358115568642	HLA-DRB1/HLA-DMA/HLA-DPA1/CD86/TNF	3.60948442980738
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/76	93/9376	5.30616864742501	HLA-DRB1/HLA-DMA/HLA-DPA1/MAML3	3.77258725918094
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	5/76	155/9376	3.97962648556876	CLEC7A/HLA-DRB1/HLA-DMA/HLA-DPA1/STX12	3.38134608911099
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/76	99/9376	4.9845826687932	HLA-DRB1/ICAM1/HLA-DMA/HLA-DPA1	3.60286194181801
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/76	56/9376	6.60902255639098	HSPA1B/PYCARD/TNF	3.80560933653968
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	7/76	300/9376	2.87859649122807	NR4A1/HSPA1B/MEF2C/DUSP2/GADD45B/TNF/STK4	2.98949513264599
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/76	168/9376	3.67167919799499	TNFAIP3/PYCARD/TNF/CAMK2D/BIRC3	3.15869181196469
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/76	115/9376	4.29107551487414	MEF2C/GNAI2/MEF2A/SGK1	3.2100277410014
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/76	116/9376	4.2540834845735	MMP9/ICAM1/GNAI2/VAV3	3.18788871284465
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/76	122/9376	4.04486626402071	LCP2/PTPRC/VAV3/TNF	3.06009106082321
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/76	187/9376	3.2986208837602	TNFAIP3/PYCARD/TNF/OAS2/BIRC3	2.87015258540864
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/76	69/9376	5.36384439359268	LCP2/VAV3/TNF	3.28881848343968
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/76	133/9376	3.71032845271072	GADD45B/SGK1/CAT/STK4	2.84572040736128
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/76	136/9376	3.62848297213622	HSPA1B/MX1/TNFAIP3/OAS2	2.79119126004139
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/76	78/9376	4.74493927125506	LSM6/NUDT16/BTG2	3.00225979196579
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/76	78/9376	4.74493927125506	GNAI2/PYCARD/TNF	3.00225979196579
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/76	139/9376	3.55017039000379	MMP9/HSPA1B/GNAI2/FKBP5	2.73818058784813
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/76	298/9376	2.48392794065701	PRL/IL1RL1/TNFSF9/CXCL16/TNF/IL1R2	2.35329740045918
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/76	156/9376	3.16329284750337	MX1/YWHAH/TNF/OAS2	2.46299263444969
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/76	94/9376	3.93729003359462	MMP9/TNFAIP3/TNF	2.58726513713971
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/76	98/9376	3.7765843179377	PTPRC/VAV3/ACTR2	2.49774259594491
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	5/76	248/9376	2.48726655348048	PTPRC/PYCARD/ACTR2/TNF/BIRC3	2.14574345326654
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/76	105/9376	3.52481203007519	CLEC7A/PYCARD/TNF	2.35185948078818
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/76	109/9376	3.39546112988894	HLA-DRB1/HLA-DMA/HLA-DPA1	2.27396489400917
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/76	50/9376	4.93473684210526	ICAM1/TNF	2.5217611423514
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	4/76	204/9376	2.41898864809082	MMP9/VAV3/TNF/CAMK2D	1.85230688869497
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/76	62/9376	3.97962648556876	HSPA1B/CAT	2.12784757152536
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/76	12/9376	10.280701754386	NCAM1	2.90798188592921
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/76	214/9376	2.30595179537629	B2M/BST2/GNAI2/TNF	1.74698771020422
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/76	140/9376	2.64360902255639	MEF2C/GNAI2/MEF2A	1.77121602342405
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/76	142/9376	2.60637509266123	LCP2/TNF/TYROBP	1.74360119821186
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/76	72/9376	3.42690058479532	ISG15/TNF	1.86867744526823
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/76	73/9376	3.37995674116799	MX1/BST2	1.84531258188838
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/76	73/9376	3.37995674116799	GADD45B/STK4	1.84531258188838
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/76	16/9376	7.71052631578947	GLA	2.42845248687261
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/76	76/9376	3.24653739612188	GNAI2/CAMK2D	1.77758318832723
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/76	76/9376	3.24653739612188	GADD45B/CAMK2D	1.77758318832723
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	4/76	238/9376	2.0734188412207	MX1/ISG15/TNF/OAS2	1.5162928103135
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/76	154/9376	2.40328092959672	SCN7A/GNAI2/CAMK2D	1.58724286968534
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/76	154/9376	2.40328092959672	MEF2C/GNAI2/CAMK2D	1.58724286968534
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/76	17/9376	7.25696594427245	SEPHS2	2.33412703200873
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/76	155/9376	2.38777589134126	NR4A1/GNAI2/CAMK2D	1.57487879956657
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/76	157/9376	2.35735836406302	DUSP2/SGK1/CAMK2D	1.55043442333923
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/76	158/9376	2.34243837441706	YWHAH/GADD45B/CCNH	1.5383512539837
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/76	166/9376	2.22954977805961	MEF2C/GNAI2/MEF2A	1.44484515091414
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/76	174/9376	2.12704174228675	HSPA1B/PPP1R15A/DNAJB1	1.35651459588975
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/76	93/9376	2.65308432371251	GADD45B/BIRC3	1.4482490976564
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/76	97/9376	2.54367878459034	GNAI2/CAMK2D	1.38147546212015
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/76	98/9376	2.51772287862513	NR4A1/CAMK2D	1.36530378648749
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/76	26/9376	4.74493927125506	APOA1	1.72852875274091
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/76	101/9376	2.44293903074518	GNAI2/CAMK2D	1.31796133276368
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/76	101/9376	2.44293903074518	ICAM1/TNF	1.31796133276368
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/76	103/9376	2.39550332141032	GNAI2/TNF	1.28733126516437
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/76	103/9376	2.39550332141032	TNF/IL1R2	1.28733126516437
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/76	193/9376	1.91764385055904	CXCL16/GNAI2/VAV3	1.16442489252475
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/76	106/9376	2.32770605759682	MMP9/IL1R2	1.24269903855004
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/76	196/9376	1.88829215896885	ICAM1/ZFP36/CD86	1.13609195297845
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/76	30/9376	4.11228070175439	TNF	1.54339631466192
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	3/76	200/9376	1.85052631578947	PYCARD/ACTR2/TNF	1.09907419419883
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/76	109/9376	2.2636407532593	CD86/TNF	1.19954971328805
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/76	31/9376	3.97962648556876	CAT	1.50211775720421
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	3/76	203/9376	1.82317863624579	PARVG/VAV3/BIRC3	1.07185829442694
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/76	32/9376	3.85526315789474	GLA	1.46253300605476
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/76	32/9376	3.85526315789474	BIRC3	1.46253300605476
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	3/76	205/9376	1.80539152759949	SP100/HDAC9/YWHAH	1.05396599855924
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/76	115/9376	2.14553775743707	GNAI2/CAMK2D	1.11732713610437
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	3/76	212/9376	1.74577954319762	LCP2/GNAI2/VAV3	0.992857262064837
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/76	37/9376	3.33428165007112	GADD45B	1.2860412249636
NA	NA	hsa04081	Hormone signaling	3/76	219/9376	1.68997837058399	PRL/GNAI2/THRB	0.933967764702201
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/76	38/9376	3.24653739612188	SGK1	1.25438102515844
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/76	38/9376	3.24653739612188	PTPRC	1.25438102515844
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/76	125/9376	1.97389473684211	GNAI2/TNF	0.990885891604079
Organismal Systems	Immune system	hsa04611	Platelet activation	2/76	126/9376	1.95822890559733	LCP2/GNAI2	0.978891672044117
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/76	226/9376	1.6376339077783	GNAI2/VAV3/CAMK2D	0.877134182943804
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	3/76	227/9376	1.63041966148852	B2M/GNAI2/TNF	0.869174195553644
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	4/76	333/9376	1.48190295558717	MX1/ISG15/MAML3/TNF	0.809424603700494
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/76	130/9376	1.89797570850202	MMP9/GNAI2	0.931987913464648
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/76	41/9376	3.00898587933248	MMP9	1.1653667198359
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/76	42/9376	2.93734335839599	CAT	1.13749188025049
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	3/76	232/9376	1.59528130671506	RGCC/VAV3/ACTR2	0.829944571554465
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/76	133/9376	1.85516422635536	GNAI2/CAMK2D	0.897883165470539
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/76	43/9376	2.86903304773562	APOA1	1.11043089247274
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/76	44/9376	2.80382775119617	MGAT4A	1.08413907402971
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/76	44/9376	2.80382775119617	CCNH	1.08413907402971
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/76	138/9376	1.78794813119756	YWHAH/CAMK2D	0.842944835388786
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/76	47/9376	2.62486002239642	TNF	1.00948134118345
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/76	49/9376	2.51772287862513	GNAI2	0.96287628967578
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/76	250/9376	1.48042105263158	LAPTM5/VPS13C/GLA	0.69598962008673
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	3/76	253/9376	1.462866652798	PYCARD/ACTR2/TNF	0.674680683776061
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	4/76	362/9376	1.36318697295725	PRL/NR4A1/YWHAH/SGK1	0.637054710064071
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/76	52/9376	2.37246963562753	APOA1	0.897127654766415
NA	NA	hsa04518	Integrin signaling	2/76	154/9376	1.60218728639781	ICAM1/PARVG	0.681130525179143
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/76	55/9376	2.24306220095694	GLA	0.835783727815641
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/76	157/9376	1.57157224270868	YWHAH/BIRC3	0.652874954752629
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/76	56/9376	2.20300751879699	MGAT4A	0.816216479686795
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/76	158/9376	1.5616255829447	SGK1/TNF	0.64358814248549
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/76	163/9376	1.513722957701	MMP9/TNF	0.598099171713967
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/76	59/9376	2.09099018733274	GNAI2	0.759905805765214
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/76	59/9376	2.09099018733274	GADD45B	0.759905805765214
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	3/76	275/9376	1.34583732057416	HSPA1B/NCAM1/TNF	0.526192444175627
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/76	60/9376	2.05614035087719	GNAI2	0.741879688441631
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/76	62/9376	1.98981324278438	MAML3	0.706857626324381
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/76	63/9376	1.95822890559733	CCNH	0.689835755314544
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/76	63/9376	1.95822890559733	GADD45B	0.689835755314544
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/76	65/9376	1.89797570850202	GLA	0.656710656402575
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/76	65/9376	1.89797570850202	NR4A1	0.656710656402575
NA	NA	hsa04519	Cadherin signaling	4/76	404/9376	1.22146951537259	CDH2/YWHAH/VAV3/ACTR2	0.41134949216251
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/76	67/9376	1.84131971720346	CAMK2D	0.624737986351972
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/76	68/9376	1.81424148606811	CYP2S1	0.609158705732838
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/76	68/9376	1.81424148606811	BCL2A1	0.609158705732838
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/76	69/9376	1.78794813119756	GNAI2	0.593838401222372
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/76	69/9376	1.78794813119756	CAMK2D	0.593838401222372
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/76	70/9376	1.76240601503759	TNF	0.578768345121178
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/76	71/9376	1.73758339510749	PRL	0.563940229550125
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/76	184/9376	1.34096109839817	GNAI2/CAMK2D	0.422240313348215
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/76	73/9376	1.68997837058399	GADD45B	0.534978534040346
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/76	75/9376	1.64491228070175	BIRC3	0.506894310482664
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/76	75/9376	1.64491228070175	GADD45B	0.506894310482664
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/76	191/9376	1.29181592725269	GNAI2/HDAC9	0.368329967989154
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/76	76/9376	1.62326869806094	APOA1	0.493164263099417
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/76	77/9376	1.60218728639781	GADD45B	0.479633800724959
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/76	77/9376	1.60218728639781	GADD45B	0.479633800724959
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/76	78/9376	1.58164642375169	ACTR2	0.46629692624766
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/76	195/9376	1.26531713900135	CLEC7A/HDAC9	0.338445370254413
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/76	79/9376	1.5616255829447	CYP2S1	0.453147900944784
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/76	83/9376	1.4863665187064	CAT	0.402323784897143
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/76	83/9376	1.4863665187064	PYCARD	0.402323784897143
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	2/76	205/9376	1.20359435173299	MMP9/CAMK2D	0.266431315542708
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/76	85/9376	1.45139318885449	NUDT16	0.377906354402205
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/76	86/9376	1.43451652386781	CAMK2D	0.365930513595306
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/76	86/9376	1.43451652386781	CAMK2D	0.365930513595306
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/76	86/9376	1.43451652386781	CDH2	0.365930513595306
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/76	87/9376	1.41802782819117	GADD45B	0.354104380044467
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/76	89/9376	1.38616203429923	GNAI2	0.330885559641311
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/76	89/9376	1.38616203429923	GNAI2	0.330885559641311
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/76	90/9376	1.37076023391813	CAT	0.319485404605958
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/76	91/9376	1.3556969346443	VAV3	0.308220006088872
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/76	91/9376	1.3556969346443	GNAI2	0.308220006088872
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/76	93/9376	1.32654216185625	CAMK2D	0.286080016894126
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/76	93/9376	1.32654216185625	CST3	0.286080016894126
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/76	99/9376	1.2461456671983	MMP9	0.222565053910839
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/76	99/9376	1.2461456671983	CAMK2D	0.222565053910839
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/76	99/9376	1.2461456671983	TNF	0.222565053910839
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/76	100/9376	1.23368421052632	TNF	0.212373321408622
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/76	105/9376	1.1749373433584	TNF	0.162953932657351
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/76	107/9376	1.15297589768815	CAMK2D	0.14386310127792
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/76	109/9376	1.13182037662965	TNF	0.125134532566923
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/76	243/9376	1.01537795105047	LSM6/HSPA1B	0.0219556269080467
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/76	110/9376	1.12153110047847	CAMK2D	0.115901374187602
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/76	110/9376	1.12153110047847	TNF	0.115901374187602
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/76	110/9376	1.12153110047847	GNAI2	0.115901374187602
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	2/76	250/9376	0.986947368421053	HSPA1B/ACTR2	-0.018909446295082
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/76	115/9376	1.07276887871854	GNAI2	0.0709768336558506
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/76	116/9376	1.06352087114338	CAT	0.0622287255714236
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/76	116/9376	1.06352087114338	GNAI2	0.0622287255714236
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/76	254/9376	0.971404890178201	STIM2/CAMK2D	-0.0417651988274224
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/76	120/9376	1.0280701754386	CAMK2D	0.0279753183332917
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/76	122/9376	1.01121656600518	THRB	0.0112726505499296
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/76	122/9376	1.01121656600518	GNAI2	0.0112726505499296
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	2/76	268/9376	0.920659858601728	GNAI2/CAMK2D	-0.11912415039722
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/76	128/9376	0.963815789473684	NUDT16	-0.0372607108417472
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/76	142/9376	0.868791697553744	BIRC3	-0.142416895285417
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/76	144/9376	0.85672514619883	TNF	-0.156622546992883
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/76	148/9376	0.833570412517781	GADD45B	-0.184483938445699
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/76	149/9376	0.827975980219004	GNAI2	-0.191338747086449
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/76	150/9376	0.822456140350877	GADD45B	-0.198150659117647
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/76	157/9376	0.785786121354341	GADD45B	-0.244684513833976
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/76	157/9376	0.785786121354341	TNF	-0.244684513833976
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/76	168/9376	0.734335839598997	PRL	-0.314091305880166
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/76	170/9376	0.725696594427245	ACTR2	-0.326265486496507
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	1/76	170/9376	0.725696594427245	GADD45B	-0.326265486496507
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	3/76	480/9376	0.771052631578947	TNF/CAT/CAMK2D	-0.465489455565365
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/76	178/9376	0.693081017149616	CAMK2D	-0.373712830778481
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/76	194/9376	0.635919696147585	KIF26B	-0.463212601594155
NA	NA	hsa04082	Neuroactive ligand signaling	1/76	199/9376	0.619941814334832	GNAI2	-0.489865916133684
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	2/76	368/9376	0.670480549199085	TNF/CAT	-0.582963999111766
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/76	370/9376	0.666856330014225	PRL/THRB	-0.591040738625743
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	1/76	217/9376	0.568518069366966	GNAI2	-0.581325549448839
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	1/76	227/9376	0.543473220496174	CAT	-0.629424049667203
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	1/76	233/9376	0.529478201942625	FBN2	-0.657452390275899
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/76	238/9376	0.518354710305175	STK4	-0.680363770264278
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	1/76	323/9376	0.381945576014339	MMP9	-1.02183948541461
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	1/76	388/9376	0.317959848073793	TNF	-1.24035280594415
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/76	449/9376	0.274762630406752	CAMK2D	-1.42364444298251