category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	41/359	138/9376	7.75939606798272	NDUFB4/COX6B1/UQCR10/COX7B/UQCR11/ATP5F1E/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/ATP6V1G1/UQCRH/NDUFB8/COX5B/COX17/ATP5PF/COX5A/ATP5MC2/NDUFC1/NDUFA1/ATP5ME/NDUFA4/ATP5MG/NDUFAB1/NDUFB7/ATP5F1C/NDUFS5/NDUFA5/NDUFA2/NDUFB1/ATP6V1F/COX4I1/NDUFS6/NDUFA3/NDUFB3/ATP5F1D/NDUFV2	15.9610069478965
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	44/359	205/9376	5.60559820639989	NDUFB4/COX6B1/UQCR10/COX7B/UQCR11/ATP5F1E/MMP9/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/MPC2/COX6A1/NDUFB2/UQCRH/GAPDH/NDUFB8/COX5B/ATP5PF/COX5A/ATP5MC2/TGFB2/NDUFC1/NDUFA1/VDAC2/PPP1CA/NDUFA4/PDK4/NDUFAB1/MPC1/NDUFB7/ATP5F1C/NDUFS5/NDUFA5/NDUFA2/NDUFB1/COX4I1/NDUFS6/NDUFA3/NDUFB3/ATP5F1D/NDUFV2	13.3032103678806
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	45/359	235/9376	5.00112605938482	NDUFB4/COX6B1/UQCR10/COX7B/UQCR11/ATP5F1E/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/COA3/UQCRH/NDUFB8/COX5B/COX17/ATP5PF/COX5A/ATP5MC2/COX20/NDUFC1/NDUFA1/NDUFAF3/ATP5ME/NDUFA4/ATP5MG/COX14/NDUFAB1/NDUFB7/ATP5F1C/NDUFS5/NDUFA5/NDUFA2/NDUFAF8/NDUFB1/PPARGC1A/COX4I1/NDUFS6/NDUFA3/NDUFB3/ATP5F1D/NDUFV2	12.3942753105704
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	44/359	227/9376	5.0623243714184	NDUFB4/COX6B1/UQCR10/COX7B/UQCR11/GSTO1/ATP5F1E/COX8A/MGST1/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/UQCRH/MGST3/NDUFB8/AKR1C3/COX5B/ATP5PF/COX5A/ATP5MC2/NDUFC1/NDUFA1/SOD2/VDAC2/NDUFA4/NDUFAB1/NDUFB7/ATP5F1C/NDUFS5/NDUFA5/NDUFA2/NDUFB1/CAT/COX4I1/NDUFS6/NDUFA3/MGST2/NDUFB3/ATP5F1D/NDUFV2	12.3623928600678
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	33/359	157/9376	5.4895587530827	NDUFB4/COX6B1/UQCR10/COX7B/UQCR11/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/UQCRH/NDUFB8/COX5B/COX5A/NDUFC1/NDUFA1/NDUFA4/NDUFAB1/NDUFB7/NDUFS5/NDUFA5/NDUFA2/NDUFB1/COX4I1/NDUFS6/GSK3A/NDUFA3/NDUFB3/LEPR/NDUFV2	11.319139328778
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	43/359	268/9376	4.19041283831539	CALM2/NDUFB4/COX6B1/UQCR10/COX7B/UQCR11/ATP5F1E/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/UQCRH/TUBA4A/NDUFB8/COX5B/ATP5PF/COX5A/ATP5MC2/NDUFC1/UBA52/NDUFA1/VDAC2/SEM1/NDUFA4/NDUFAB1/CALM1/NDUFB7/ATP5F1C/NDUFS5/SLC39A4/NDUFA5/NDUFA2/NDUFB1/COX4I1/NDUFS6/NDUFA3/NDUFB3/ATP5F1D/NDUFV2	10.573154976466
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	46/359	308/9376	3.90058966103534	GPX3/NDUFB4/COX6B1/UQCR10/POLR2J/COX7B/UQCR11/ATP5F1E/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/HAP1/UQCRH/TUBA4A/NDUFB8/POLR2I/COX5B/ATP5PF/COX5A/ATP5MC2/NDUFC1/NDUFA1/SOD2/VDAC2/SEM1/NDUFA4/NDUFAB1/NDUFB7/ATP5F1C/NDUFS5/NDUFA5/NDUFA2/NDUFB1/PPARGC1A/COX4I1/POLR2K/NDUFS6/NDUFA3/NDUFB3/ATP5F1D/NDUFV2	10.3277977565758
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	39/359	275/9376	3.7038642694353	NDUFB4/COX6B1/UQCR10/COX7B/UQCR11/ATP5F1E/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/UQCRH/TUBA4A/NDUFB8/COX5B/ATP5PF/COX5A/ATP5MC2/NDUFC1/NDUFA1/VDAC2/SEM1/NDUFA4/NDUFAB1/NDUFB7/ATP5F1C/NDUFS5/NDUFA5/NDUFA2/NDUFB1/COX4I1/NDUFS6/NDUFA3/NDUFB3/ATP5F1D/NDUFV2	9.0804736846381
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	45/359	368/9376	3.19365386944411	GPX3/NDUFB4/CHCHD10/COX6B1/UQCR10/COX7B/UQCR11/ATP5F1E/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/HAP1/UQCRH/TUBA4A/NDUFB8/COX5B/ATP5PF/COX5A/ATP5MC2/NDUFC1/NDUFA1/ANG/SEM1/NDUFA4/NDUFAB1/NDUFB7/ATP5F1C/NDUFS5/NDUFA5/PFN1/NDUFA2/MAP2K6/NDUFB1/CAT/COX4I1/NDUFS6/NDUFA3/NDUFB3/ATP5F1D/NDUFV2	8.56603117764582
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	45/359	388/9376	3.02903253596761	CALM2/NDUFB4/COX6B1/UQCR10/COX7B/UQCR11/ATP5F1E/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/UQCRH/GAPDH/TUBA4A/NDUFB8/COX5B/ATP5PF/COX5A/ATP5MC2/NDUFC1/NDUFA1/VDAC2/SEM1/NDUFA4/NDUFAB1/CALM1/NDUFB7/ATP5F1C/NDUFS5/SLC39A4/NDUFA5/APH1A/NDUFA2/NDUFB1/COX4I1/NDUFS6/NDUFA3/NDUFB3/PSENEN/ATP5F1D/NDUFV2	8.14470145215103
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	46/359	480/9376	2.50287836583101	GPX3/CALM2/NDUFB4/COX6B1/UQCR10/COX7B/UQCR11/ATP5F1E/COX8A/NDUFA7/UQCRQ/COX7A2/NDUFA6/COX7C/COX6A1/NDUFB2/HAP1/UQCRH/TUBA4A/NDUFB8/COX5B/ATP5PF/COX5A/ATP5MC2/NDUFC1/UBA52/NDUFA1/VDAC2/SEM1/NDUFA4/NDUFAB1/CALM1/NDUFB7/ATP5F1C/NDUFS5/NDUFA5/NDUFA2/MAP2K6/NDUFB1/CAT/COX4I1/NDUFS6/NDUFA3/NDUFB3/ATP5F1D/NDUFV2	6.74448653527269
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	20/359	149/9376	3.5056364622086	NDUFB4/NDUFA7/NDUFA6/NDUFB2/NDUFB8/NDUFC1/NDUFA1/GABRP/NDUFA4/GNG10/NDUFAB1/NDUFB7/NDUFS5/NDUFA5/NDUFA2/NDUFB1/NDUFS6/NDUFA3/NDUFB3/NDUFV2	6.15152455421424
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/359	61/9376	5.1377688478926	FTH1/MT1M/MT2A/FXYD2/MT1F/MT1G/MT1H/SLC40A1/SLC34A2/MT1E/SLC39A4/MT1X	6.46906539128065
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	14/359	87/9376	4.20273428745237	COX6B1/UQCR10/COX7B/UQCR11/FXYD2/COX8A/UQCRQ/COX7A2/COX7C/COX6A1/UQCRH/COX5B/COX5A/COX4I1	5.98822185218594
Genetic Information Processing	Translation	hsa03010	Ribosome	22/359	222/9376	2.58817034304499	RPLP1/RPL39/RPL36AL/RPL41/FAU/MRPL34/UBA52/RPS12/MRPL33/MRPS15/MRPS2/MRPL54/RPS27L/MRPL13/MRPL20/MRPS26/MRPL12/MRPL28/MRPL52/MRPL46/RPL38/RPS25	4.77826181926606
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/359	31/9376	5.8973852098122	SEC61G/SEC61B/SEC11A/SEC11C/SRP9/SRP14/SRP19	5.44950790667714
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/359	10/9376	10.4467966573816	TST/MPST/ETHE1/SQOR	5.96361115165267
NA	NA	hsa04382	Cornified envelope formation	18/359	217/9376	2.16638640360448	S100A10/S100A11/S100A1/S100A13/KRT8/KRT7/CLDN1/CLDN4/PPP2R5A/KRT18/KRT10/KRT23/HAL/S100A14/JUP/DSG2/OCLN/KDSR	3.46856720500857
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/359	20/9376	5.22339832869081	CYP24A1/EBP/LBR/SC5D	3.77253921274774
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/359	105/9376	2.48733253747181	FIS1/UBA52/ATG9B/BNIP3/FKBP8/GABARAPL2/GABARAPL1/TOMM7/TBC1D15/CITED2	3.05802664731731
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/359	59/9376	3.09862612718946	GPX3/GSTO1/MGST1/GPX4/MGST3/IDH1/MGST2	3.2264494192988
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/359	63/9376	2.90188796038378	GTF2H5/POLR2J/POLR2I/RBX1/RPA3/RAD23A/POLR2K	3.02212365422815
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/359	42/9376	3.10916567183977	FTH1/GPX4/SLC40A1/VDAC2/PCBP1	2.73340049570877
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/359	82/9376	2.22949928663632	CDA/GSTO1/UGT2B7/MGST1/MGST3/UPP1/MGST2	2.23118561295559
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/359	142/9376	1.83922476362352	CALM2/GSTO1/MMP9/MGST1/MGST3/SDC4/EDN1/CALM1/MAP2K6/MGST2	2.01061702274394
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/359	70/9376	2.23859928372463	GSTO1/UGT2B7/MGST1/MGST3/CYP3A5/MGST2	2.07539204661371
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/359	55/9376	2.37427196758673	PLPP2/SGPP2/CERS2/KDSR/CERK	2.03950421055297
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/359	73/9376	2.14660205288663	GSTO1/UGT2B7/MGST1/MGST3/CYP3A5/MGST2	1.96229574544978
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/359	75/9376	2.08935933147632	GAPDH/IDH1/ARG2/TALDO1/PYCR2/ACO2	1.88989986976841
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	14/359	238/9376	1.53629362608553	RPLP1/RPL39/RPL36AL/FGB/FGA/RPL41/FAU/ISG15/UBA52/RPS12/RPS27L/RPL38/HBEGF/RPS25	1.67211970440639
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/359	79/9376	1.98356898557879	GSTO1/UGT2B7/MGST1/MGST3/CYP3A5/MGST2	1.75165584942725
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/359	44/9376	2.37427196758673	AQP3/RAB11A/VAMP2/RAB11B	1.82311258353802
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/359	28/9376	2.79824910465579	PCBD1/AKR1C3/MOCOS	1.9013906072909
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/359	63/9376	2.07277711455984	PLAAT3/GPX4/AKR1C3/HPGD/LTC4S	1.70465619487475
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/359	30/9376	2.6116991643454	IDH1/MDH2/ACO2	1.76414203167903
NA	NA	hsa03272	Virion - Hepatitis viruses	4/359	48/9376	2.17641597028784	CLDN1/CLDN4/CD9/OCLN	1.63038093869861
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/359	31/9376	2.52745080420523	MDH2/CAT/ACO2	1.69965295315129
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/359	32/9376	2.44846796657382	ATG9B/GABARAPL2/GABARAPL1	1.63764324058269
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/359	194/9376	1.4808603509175	DYNLT3/DYNLRB1/CAPZA2/TUBA4A/DYNLT1/MYO1C/KIF12/KIF22/MYL12A/KIFC3/KIF9	1.35037073501232
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/359	110/9376	1.66199037731071	ID1/TGFB2/GREM2/RBX1/TGIF1/ID3/SMAD9	1.39348949436833
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/359	51/9376	2.04839150144738	SEC61G/ATP6V1G1/SEC61B/ATP6V1F	1.49791092130272
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	10/359	174/9376	1.50097653123299	SEC61G/KRTCAP2/SEC61B/TMEM258/RBX1/SVIP/CRYAB/SSR4/RAD23A/BAG1	1.33092235160427
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/359	33/9376	2.37427196758673	VAMP8/VAMP2/BET1	1.57793209949495
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/359	52/9376	2.00899935718877	APOA1/VDAC2/VAPA/TSPO	1.45577164670492
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/359	133/9376	1.57094686577167	DEPP1/TGFB2/SOD2/BNIP3/GADD45A/GABARAPL2/CAT/GABARAPL1	1.32317371457302
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/359	34/9376	2.3044404391283	POLR2J/POLR2I/POLR2K	1.52035710723483
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/359	34/9376	2.3044404391283	RORC/RBX1/NR1D1	1.52035710723483
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/359	54/9376	1.93459197358919	MDH2/TST/MPST/LDHA	1.37425145415974
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	13/359	248/9376	1.36903585227783	S100A10/DYNLT3/DYNLRB1/GAPDH/TUBA4A/DYNLT1/TRADD/ANXA2/ARPC3/PFN1/MAP2K6/MYL12A/ARF6	1.17519088087194
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/359	116/9376	1.57602535779464	GAPDH/IDH1/MDH2/TALDO1/CAT/ESD/ACO2	1.24556653466856
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/359	116/9376	1.57602535779464	MMP9/CXCR4/CLDN1/CLDN4/MYL12A/F11R/OCLN	1.24556653466856
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/359	138/9376	1.5140285010698	CALM2/PPP2R5A/ANAPC16/PPP1CA/RBX1/YWHAH/CALM1/REC8	1.21377892262502
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/359	56/9376	1.86549940310386	KRTCAP2/SRD5A3/TMEM258/DPM3	1.29614818985917
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/359	37/9376	2.11759391703681	MIF/FAHD1/HGD	1.3590534309196
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/359	21/9376	2.48733253747181	CHPF/CSGALNACT1	1.36143734049923
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/359	21/9376	2.48733253747181	VNN1/PPCS	1.36143734049923
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	9/359	170/9376	1.38266426347698	CLDN1/CLDN4/TUBA4A/ARPC3/MARVELD2/MYL12A/PARD6B/F11R/OCLN	1.00463593620274
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/359	22/9376	2.37427196758673	HNMT/HAL	1.28761839708207
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/359	41/9376	1.91099938854542	SEM1/RPA3/SSBP1	1.16641925519806
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/359	62/9376	1.68496720280349	SOD2/CRYAB/CAT/FOXA2	1.07969063138524
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/359	23/9376	2.2710427516047	RPA3/SSBP1	1.21772840557935
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/359	85/9376	1.53629362608553	CDA/DCTPP1/ADA2/PNP/UPP1	0.991020631295562
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/359	43/9376	1.82211569605493	APOA1/PLPP2/AGPAT2	1.07809830311806
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/359	66/9376	1.58284797839115	UGT2B7/AKR1C3/SRD5A3/CYP3A5	0.948100224451329
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	12/359	250/9376	1.25361559888579	CAPZA2/CXCR4/RAB11A/CHMP2A/ARPC3/VPS29/CHMP5/RAB11FIP1/PARD6B/WWP1/ARF6/RAB11B	0.810975177664106
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/359	89/9376	1.46724672154236	HAP1/GABRP/GNG10/GABARAPL2/GABARAPL1	0.883701049997859
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/359	46/9376	1.70328206370352	FTH1/UGT2B7/BLVRA	0.954046325195143
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/359	26/9376	2.00899935718877	FOXA2/HNF1B	1.02795377500816
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	12/359	253/9376	1.23875059178438	UBA52/BNIP3/TRADD/CAPNS1/RBX1/ARPC3/PFN1/MYL12A/RBCK1/BCL10/GSK3A/ARF6	0.768135271297926
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/359	139/9376	1.3152441834833	CALM2/MMP9/KRT18/KRT10/KRT23/CALM1/HBEGF	0.747120818520273
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/359	71/9376	1.47137981089882	ATP6V1G1/ATP6V1F/F11R/HBEGF	0.795506607244599
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/359	28/9376	1.86549940310386	ATP6V1G1/ATP6V1F	0.915141529289159
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/359	29/9376	1.80117183747959	CALM2/CALM1	0.862164983105953
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/359	51/9376	1.53629362608553	PLAAT3/PLPP2/CHPT1	0.766240548907078
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/359	168/9376	1.24366626873591	FTH1/PPIA/VDAC2/TRADD/CHMP2A/CHMP5/HMGB1/RBCK1	0.63587130383272
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/359	75/9376	1.39290622098422	GSTO1/MGST1/MGST3/MGST2	0.681642314352734
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/359	99/9376	1.31903998199263	HLA-DMA/KRT18/KRT10/KRT23/DEFB1	0.636737985039268
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/359	78/9376	1.33933290479251	DCPS/LSM4/LSM5/LSM3	0.600454816575506
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/359	200/9376	1.17526462395543	CLDN1/CLDN4/GAPDH/TUBA4A/TRADD/MYO1C/ARPC3/ARF6/OCLN	0.49990144073753
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/359	79/9376	1.32237932371919	ATP6V1G1/ATP6V1F/VAMP2/NAPA	0.574131185922687
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/359	33/9376	1.58284797839115	IDH1/ACO2	0.669223091149969
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/359	201/9376	1.16941753627406	NUPR1/MMP9/LMO2/HPGD/SPINT1/GADD45A/PAX8/JUP/ELK4	0.484456940003539
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/359	104/9376	1.25562459824298	PLAAT3/PLPP2/GPD1L/AGPAT2/CHPT1	0.523039428384919
NA	NA	hsa04519	Cadherin signaling	17/359	404/9376	1.09898232163049	KRT8/KRT7/KRT18/WWC1/GABRP/KRT10/PPP1CA/KRT23/YWHAH/PCDH17/MYO1C/ARPC3/TMC5/JUP/APH1A/DSG2/PSENEN	0.405793899444459
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/359	83/9376	1.25865019968453	IDH1/SOD2/PMVK/CAT	0.472254085040028
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/359	59/9376	1.32798262593834	CDA/DCTPP1/UPP1	0.504243866636718
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/359	157/9376	1.16445185671451	CALM2/TGFB2/VDAC2/PPP1CA/CALM1/GADD45A/MAP2K6	0.414618358151489
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/359	133/9376	1.17821014932875	CALM2/PPP2R5A/PPP1CA/GNG10/CALM1/GSK3A	0.413003379821057
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/359	36/9376	1.45094398019189	GCNT3/ST6GALNAC1	0.540881632432675
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/359	36/9376	1.45094398019189	RPA3/SSBP1	0.540881632432675
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/359	110/9376	1.18713598379337	GAPDH/RBX1/EDN1/LDHA/ELOC	0.393921175249863
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/359	160/9376	1.14261838440111	HLA-DMA/CLDN1/CLDN4/SDC4/LRRC4C/F11R/OCLN	0.363049713472207
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/359	37/9376	1.41172927802454	GADD45A/PAX8	0.500684622007362
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/359	38/9376	1.37457850755021	NMRK1/PNP	0.461646498747879
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/359	214/9376	1.09837815322938	CALM2/CXCR4/TRADD/RBX1/GNG10/CALM1/AP1M2/MAP2K6/ELOC	0.290477324829913
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/359	16/9376	1.63231197771588	MIF	0.505074337934597
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/359	66/9376	1.18713598379337	HLA-DMA/RORC/TGFB2	0.304408138683359
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/359	117/9376	1.11611075399376	CDK2AP2/MEAF6/MBD2/BCL7A/CHRAC1	0.252165205852805
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/359	41/9376	1.27399959236361	MMP9/HBEGF	0.350821750780356
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/359	169/9376	1.08176888464011	VAMP8/UBA52/ATG9B/BNIP3/GABARAPL2/HMGB1/GABARAPL1	0.21402976873867
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/359	67/9376	1.16941753627406	CALM2/PPP1CA/CALM1	0.277680943079259
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/359	93/9376	1.12331146853566	CALM2/CALM1/MAP2K6/HBEGF	0.238452893407155
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/359	93/9376	1.12331146853566	CALM2/FXYD2/CALM1/VAMP2	0.238452893407155
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/359	119/9376	1.09735259006109	MMP9/TRADD/EDN1/LIF/MAP2K6	0.213249335660986
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/359	68/9376	1.15222021956415	UGT2B7/CYP3A5/DHRS3	0.25136247315191
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/359	69/9376	1.13552137580235	CALM2/EDN1/CALM1	0.225439139462339
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/359	69/9376	1.13552137580235	CALM2/PPP1CA/CALM1	0.225439139462339
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/359	95/9376	1.09966280604017	HLA-DMA/ATP6V1G1/TGFB2/ATP6V1F	0.194804665865946
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/359	70/9376	1.11929964186232	TRADD/PPARGC1A/LEPR	0.199898006674417
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/359	70/9376	1.11929964186232	TGFB2/RBX1/ELOC	0.199898006674417
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/359	44/9376	1.18713598379337	KRTCAP2/TMEM258	0.248255057902082
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/359	44/9376	1.18713598379337	GTF2H5/GTF2A2	0.248255057902082
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/359	45/9376	1.16075518415351	ABCA6/DEFB1	0.215679554156252
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/359	125/9376	1.04467966573816	PPP2R5A/TRADD/SGPP2/CERS2/ORMDL2	0.100339610085047
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/359	99/9376	1.0552319855941	CALM2/PPP1CA/CALM1/MAP2K6	0.110231648702009
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/359	46/9376	1.13552137580235	SEM1/POMP	0.183843264662195
Organismal Systems	Immune system	hsa04611	Platelet activation	5/359	126/9376	1.03638855727992	VAMP8/FGB/FGA/PPP1CA/MYL12A	0.0820504696046146
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/359	73/9376	1.07330102644332	CXCR4/PPIA/MAP1S	0.125447440081501
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/359	100/9376	1.04467966573816	CD24/HLA-DMA/CSF2RA/CD9	0.0896254549136592
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/359	47/9376	1.11136134652996	MDH2/LDHA	0.152710072616709
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/359	181/9376	1.01004940057557	CALM2/HLA-DMA/TGFB2/TRADD/CLEC4E/CALM1/BCL10	0.0272398935531074
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/359	155/9376	1.01098032168209	SEC61G/HLA-DMA/ATP6V1G1/SEC61B/TUBA4A/ATP6V1F	0.0275038650989663
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/359	75/9376	1.04467966573816	GPX3/FXYD2/PAX8	0.0775135366448945
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/359	157/9376	0.998101591469581	CD24/ARG2/DUSP5/ATP8A1/DUSP4/RAB17	-0.00478629456491625
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/359	157/9376	0.998101591469581	ID1/TGFB2/WWC1/PPP1CA/YWHAH/PARD6B	-0.00478629456491625
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/359	76/9376	1.03093388066266	CALM2/CALM1/GADD45A	0.0540258433852673
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/359	158/9376	0.991784492789394	PPP2R5A/TGFB2/ANAPC16/RBX1/YWHAH/GADD45A	-0.0207800410136971
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/359	212/9376	0.985546854469964	CALM2/ID1/VEGFB/CALM1/RGS14/PFN1/MAP2K6/PARD6B	-0.042470717058743
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/359	105/9376	0.994933014988725	CALM2/CLEC4E/CALM1/BCL10	-0.0104179628937415
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/359	50/9376	1.04467966573816	ARG2/PYCR2	0.0632046512944349
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/359	50/9376	1.04467966573816	HLA-DMA/CXCR4	0.0632046512944349
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/359	107/9376	0.976336136203889	CALM2/CALM1/LDHA/PPARGC1A	-0.0491205173629106
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/359	23/9376	1.13552137580235	ARG2	0.129836882881686
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/359	23/9376	1.13552137580235	PMVK	0.129836882881686
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/359	23/9376	1.13552137580235	FXYD2	0.129836882881686
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/359	298/9376	0.964050027107364	CXCL14/PRL/CXCR4/IL1RL1/TGFB2/CLCF1/LIF/CSF2RA/IL20RA/TNFSF12/LEPR	-0.125838472443192
NA	NA	hsa04517	IgSF CAM signaling	11/359	299/9376	0.960825779525065	FGB/FGA/TUBA4A/ARPC3/MYL12A/PARD6B/LRRC4C/F11R/ARF6/CABLES1/LMO7	-0.137362003721544
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/359	300/9376	0.957623026926648	TGFB2/VEGFB/TRADD/DUSP5/GADD45A/DUSP4/MAP2K6/JUND/DUSP3/MAP4K3/ELK4	-0.148848733537426
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/359	53/9376	0.985546854469964	FXYD2/RAB11A	-0.0210534995801664
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/359	24/9376	1.08820798514392	HS6ST3	0.0863302704455834
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/359	138/9376	0.946267813168625	CALM2/PPP1CA/FLOT1/CALM1/PPARGC1A	-0.126878170581474
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/359	166/9376	0.943987649763399	CALM2/FXYD2/VDAC2/PPP1CA/ADRA2A/CALM1	-0.145281345149854
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	9/359	250/9376	0.940211699164345	VAMP8/ATP6V1G1/SLC15A4/VPS29/AP1M2/LAMTOR2/SLC29A1/ATP6V1F/BLOC1S2	-0.191182356706159
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/359	168/9376	0.93274970155193	PRL/CLCF1/LIF/CSF2RA/IL20RA/LEPR	-0.175496326098633
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/359	26/9376	1.00449967859439	PLAAT3	0.00458420668404576
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/359	26/9376	1.00449967859439	APOA1	0.00458420668404576
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/359	170/9376	0.921776175651319	GSTO1/MGST1/MGST3/TGFB2/GADD45A/MGST2	-0.205366616401125
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/359	142/9376	0.919612381811762	UBA52/ANAPC16/RBX1/ELOC/WWP1	-0.192592879229692
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/359	115/9376	0.90841710064188	SLC34A2/CYP24A1/JUND/HBEGF	-0.197167892412502
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/359	144/9376	0.906839987619932	ID1/LIF/ID3/DLX5/SMAD9	-0.224783647117444
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/359	27/9376	0.967295986794594	TECR	-0.0339548783860069
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/359	28/9376	0.93274970155193	TECR	-0.0711075487125829
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/359	28/9376	0.93274970155193	B3GNT5	-0.0711075487125829
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/359	90/9376	0.870566388115135	SOD2/CAT/PPARGC1A	-0.246181726530084
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/359	29/9376	0.900585918739794	WWC1	-0.10698246703209
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/359	30/9376	0.870566388115135	PLAAT3	-0.141676114308133
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/359	122/9376	0.8562948079821	PPP2R5A/PPARGC1A/LEPR/RAB11B	-0.318778817086343
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/359	62/9376	0.842483601401743	APH1A/PSENEN	-0.248287770801303
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/359	63/9376	0.829110845823938	GADD45A/GLI3	-0.271544994155336
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/359	31/9376	0.842483601401743	TALDO1	-0.175274523611637
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/359	31/9376	0.842483601401743	UGT2B7	-0.175274523611637
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/359	94/9376	0.833521009897469	MMP9/TRADD/JUND	-0.323671458720738
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/359	154/9376	0.847954274138118	CALM2/FXYD2/PPP2R5A/PPP1CA/CALM1	-0.379597938643408
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/359	32/9376	0.816155988857939	LDHA	-0.207854718997034
Human Diseases	Immune disease	hsa05310	Asthma	1/359	32/9376	0.816155988857939	HLA-DMA	-0.207854718997034
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/359	65/9376	0.803599742875509	PLPP2/AGPAT2	-0.317031484782082
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/359	156/9376	0.837083065495322	CLDN1/CLDN4/TRADD/YWHAH/OCLN	-0.40941608019036
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/359	97/9376	0.807742009591362	CALM2/GNG10/CALM1	-0.379770744459112
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/359	158/9376	0.826487077324495	ATP6V1G1/CASTOR1/FNIP2/LAMTOR2/ATP6V1F	-0.438878033598295
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/359	98/9376	0.799499744187369	CALM2/IMPA2/CALM1	-0.398109565345601
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/359	98/9376	0.799499744187369	PLPP2/ARPC3/ARF6	-0.398109565345601
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/359	67/9376	0.779611690849374	GAPDH/LDHA	-0.361223724972552
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/359	130/9376	0.803599742875509	MMP9/VEGFB/GNG10/EDN1	-0.449923431459476
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/359	100/9376	0.783509749303621	CXCL14/CXCR4/IL20RA	-0.434269972312318
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/359	101/9376	0.775752227033288	CALM2/EDN1/CALM1	-0.452099153740201
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/359	101/9376	0.775752227033288	TGFB2/VEGFB/EDN1	-0.452099153740201
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/359	102/9376	0.768146813042766	FXYD2/RAB11A/CPB1	-0.469765845076278
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/359	36/9376	0.725471990095946	UGT2B7	-0.329280719264092
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	7/359	224/9376	0.816155988857939	HLA-DMA/TGFB2/ETS2/VDAC2/ANAPC16/TSPO/ELK4	-0.555670470478528
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/359	134/9376	0.779611690849374	CALM2/PPP1CA/EDN1/CALM1	-0.512695844826812
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/359	103/9376	0.760689076993807	PPP2R5A/PPP1CA/SAP18	-0.487273543403233
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/359	71/9376	0.73568990544941	IDH1/LDHA	-0.446053101373855
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/359	37/9376	0.705864639012271	NIT2	-0.357684186904875
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/359	37/9376	0.705864639012271	APOA1	-0.357684186904875
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/359	196/9376	0.799499744187369	CALM2/UBA52/TRADD/GNG10/CALM1/MAP2K6	-0.566009152371869
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/359	72/9376	0.725471990095946	ISG15/TRADD	-0.466573304805601
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/359	105/9376	0.746199761241544	TRADD/GADD45A/BCL10	-0.521825397928918
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/359	38/9376	0.687289253775106	FXYD2	-0.385398035940989
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/359	137/9376	0.762539901998658	TUBA4A/TRADD/NOL3/GADD45A	-0.558650601075955
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/359	39/9376	0.669666452396257	HLA-DMA	-0.412461230646854
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/359	75/9376	0.696453110492108	GADD45A/SIVA1	-0.526615241062945
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/359	140/9376	0.746199761241544	CALM2/GNG10/CALM1/PPARGC1A	-0.60369267969474
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	7/359	232/9376	0.78801267889732	CXCR4/PPP1CA/ARPC3/PFN1/RGCC/MYL12A/SPATA13	-0.652360411629326
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/359	76/9376	0.687289253775106	CALM2/CALM1	-0.546147506828319
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	7/359	233/9376	0.784630650232525	CAPZA2/SDC4/TMOD1/FBN2/JUP/DSG2/LBR	-0.664231282419139
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/359	41/9376	0.636999796181806	GABRP	-0.464775753637352
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/359	204/9376	0.768146813042766	MMP9/GPC3/TGFB2/SDC4/PPP1CA/HBEGF	-0.668033064029384
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/359	77/9376	0.678363419310494	TGFB2/GADD45A	-0.565450383400795
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/359	77/9376	0.678363419310494	TGFB2/GADD45A	-0.565450383400795
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	6/359	205/9376	0.764399755418167	HLA-DMA/ISG15/TRADD/SEM1/GADD45A/MAP2K6	-0.680528234538769
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/359	78/9376	0.669666452396257	CALM2/CALM1	-0.584530315020357
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/359	78/9376	0.669666452396257	HLA-DMA/TGFB2	-0.584530315020357
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/359	42/9376	0.621833134367953	CAT	-0.490090234152928
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/359	112/9376	0.699562276163948	HLA-DMA/TGFB2/MAP2K6	-0.638213562211974
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/359	238/9376	0.768146813042766	CALM2/PLAAT3/VEGFB/ETS2/GNG10/CALM1/ARF6	-0.722899291700288
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/359	43/9376	0.607371898684978	ECI1	-0.514880924686675
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/359	44/9376	0.593567991896683	HMGB1	-0.539173704915887
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/359	44/9376	0.593567991896683	HLA-DMA	-0.539173704915887
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/359	45/9376	0.580377592076756	HLA-DMA	-0.562992567433666
Genetic Information Processing	Transcription	hsa03040	Spliceosome	7/359	243/9376	0.752341323062462	SNU13/LSM4/LSM5/SNRPF/LSM3/PCBP1/SNRPG	-0.780462038809481
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/359	83/9376	0.629325099842266	PCBP1/POLR2K	-0.676793352701066
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/359	216/9376	0.725471990095946	CALM2/APOA1/MMP9/SOD2/CALM1/MAP2K6	-0.814456002180694
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/359	48/9376	0.544103992571959	FXYD2	-0.631820868903724
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/359	86/9376	0.607371898684978	FXYD2/VAMP2	-0.729834814396232
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/359	86/9376	0.607371898684978	JUP/DSG2	-0.729834814396232
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/359	187/9376	0.698315284584333	TXNIP/VDAC2/GABARAPL2/RBCK1/GABARAPL1	-0.831460864965433
NA	NA	hsa04081	Hormone signaling	6/359	219/9376	0.715534017628878	PRL/SLC40A1/GNG10/ADRA2A/SMAD9/LEPR	-0.849919154673577
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/359	87/9376	0.600390612493196	TGFB2/GADD45A	-0.74715835028274
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/359	88/9376	0.593567991896683	FGB/FGA	-0.764310741910344
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/359	50/9376	0.522339832869081	TGFB2	-0.675706583788634
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/359	191/9376	0.683690880718692	CALM2/PPP1CA/GNG10/CALM1/SLC29A1	-0.881232780539314
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/359	90/9376	0.580377592076756	UGT2B7/FXYD2	-0.798118567263243
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/359	91/9376	0.573999816339649	GABRP/GNG10	-0.814781868720291
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/359	52/9376	0.502249839297193	AKR1C3	-0.718147703396799
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/359	226/9376	0.693371459560727	CALM2/FXYD2/PPP1CA/EDN1/CALM1/GLI3	-0.931017996524284
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/359	227/9376	0.690316959738873	CALM2/CXCR4/TRADD/GNG10/CALM1/MAP2K6	-0.942421888499149
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/359	93/9376	0.561655734267829	MYL12A/LMO7	-0.847645881713312
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/359	54/9376	0.483647993397297	RPA3	-0.759259137660835
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/359	54/9376	0.483647993397297	HLA-DMA	-0.759259137660835
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/359	56/9376	0.466374850775965	GLI3	-0.79914240119593
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/359	56/9376	0.466374850775965	BNIP3	-0.79914240119593
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/359	57/9376	0.458192835850071	TECR	-0.818652029668443
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/359	98/9376	0.532999829458246	CALM2/CALM1	-0.927266821467
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/359	99/9376	0.527615992797051	MMP9/HBEGF	-0.942781023972508
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/359	99/9376	0.527615992797051	PLPP2/CHPT1	-0.942781023972508
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/359	99/9376	0.527615992797051	TGFB2/EDN1	-0.942781023972508
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/359	59/9376	0.44266087531278	PLAAT3	-0.856858909694323
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/359	59/9376	0.44266087531278	GADD45A	-0.856858909694323
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/359	173/9376	0.603861078461365	HLA-DMA/RAB11A/TRADD/RAB11B	-1.04931935376116
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/359	138/9376	0.567760687901175	ARPC3/MAP2K6/ARF6	-1.02064956605247
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/359	103/9376	0.507126051329205	FXYD2/CPB1	-1.00356654181534
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/359	103/9376	0.507126051329205	ARG2/TGFB2	-1.00356654181534
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/359	142/9376	0.551767429087057	TGFB2/MAP2K6/JUND	-1.07387684001915
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/359	178/9376	0.586898688616945	RBX1/CTNNBIP1/CACYBP/SOX17	-1.11025234676906
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/359	106/9376	0.492773427234982	MMP9/SPINT1	-1.04789288274768
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/359	144/9376	0.544103992571959	TRADD/MAP2K6/PPARGC1A	-1.10002097077739
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/359	217/9376	0.601774001001245	GSTO1/UGT2B7/MGST1/MGST3/MGST2	-1.18423331756981
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/359	109/9376	0.479210855843193	HLA-DMA/RORC	-1.09120769000773
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/359	109/9376	0.479210855843193	PPP1CA/PPARGC1A	-1.09120769000773
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/359	184/9376	0.567760687901175	CXCR4/MYL12A/PARD6B/LRRC4C	-1.18148984904646
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/359	110/9376	0.474854393517346	ANAPC16/KIF22	-1.10543130342783
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/359	149/9376	0.525845469331289	PLPP2/AGPAT2/ARF6	-1.16408476724094
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/359	68/9376	0.384073406521383	JUP	-1.01708453883534
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/359	150/9376	0.522339832869081	TGFB2/GADD45A/JUP	-1.17668375654111
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/359	69/9376	0.37850712526745	MAP2K6	-1.03385032827605
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/359	70/9376	0.373099880620772	HLA-DMA	-1.05043135328511
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/359	71/9376	0.367844952724705	PRL	-1.06683295568308
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/359	154/9376	0.508772564482871	UGT2B7/PPCS/DHRS3	-1.22640028761333
NA	NA	hsa04518	Integrin signaling	3/359	154/9376	0.508772564482871	FGB/FGA/VEGFB	-1.22640028761333
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/359	154/9376	0.508772564482871	CALM2/PPP1CA/CALM1	-1.22640028761333
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/359	193/9376	0.541284800900602	CXCL14/CXCR4/GNG10/GSK3A	-1.28478755238359
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/359	73/9376	0.357767008814439	GADD45A	-1.09911809683069
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/359	73/9376	0.357767008814439	GADD45A	-1.09911809683069
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/359	195/9376	0.535733161917006	FGB/FGA/VDAC2/HMGB1	-1.30719929022082
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/359	120/9376	0.435283194057567	CALM2/CALM1	-1.24225710749699
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/359	76/9376	0.343644626887553	APOA1	-1.14632085704191
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/359	370/9376	0.635278175111044	PRL/NMB/SPX/GABRP/ADRA2A/EDN1/TSPO/LEPR/NR3C1	-1.4282310502819
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/359	122/9376	0.42814740399105	PPP2R5A/BCL10	-1.26853102204394
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/359	163/9376	0.480680827793633	MMP9/TGFB2/MAP2K6	-1.33453340884276
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/359	78/9376	0.334833226198129	IMPA2	-1.17702288081829
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/359	78/9376	0.334833226198129	ARPC3	-1.17702288081829
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/359	128/9376	0.408077994428969	ADA2/PNP	-1.3453874981762
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/359	82/9376	0.318499898090903	HLA-DMA	-1.23672558344242
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/359	83/9376	0.314662549921133	MBD6	-1.25131707157161
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/359	86/9376	0.303685949342489	HBEGF	-1.29433994719437
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/359	254/9376	0.51411400872941	CALM2/CXCR4/VEGFB/VDAC2/CALM1	-1.56641931622555
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/359	89/9376	0.293449344308472	SDC4	-1.33629521091176
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/359	89/9376	0.293449344308472	TUBA4A	-1.33629521091176
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/359	90/9376	0.290188796038378	MAP2K6	-1.3500554079964
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/359	180/9376	0.435283194057567	HLA-DMA/TRADD/PPP1CA	-1.52640335318707
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/359	91/9376	0.286999908169825	BCL10	-1.36370726939008
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/359	183/9376	0.42814740399105	NOP10/SNU13/POP7	-1.55877287372151
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/359	93/9376	0.280827867133914	HLA-DMA	-1.39069526927355
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/359	93/9376	0.280827867133914	GADD45A	-1.39069526927355
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/359	144/9376	0.362735995047973	VDAC2/SEM1	-1.53763963260736
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/359	103/9376	0.253563025664602	TGFB2	-1.51985954022744
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/359	105/9376	0.248733253747181	TGFB2	-1.54464026799927
NA	NA	hsa04082	Neuroactive ligand signaling	3/359	199/9376	0.393723492112372	GABRP/GNG10/ADRA2A	-1.72483970327991
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/359	108/9376	0.241823996698648	SAP18	-1.58121427876746
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	3/359	203/9376	0.385965393745626	VEGFB/PPP1CA/MYL12A	-1.76476547152633
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/359	109/9376	0.239605427921597	MAP2K6	-1.59325211326268
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	3/359	205/9376	0.382199877709084	TRADD/YWHAH/GTF2A2	-1.78450759788766
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/359	115/9376	0.22710427516047	GNG10	-1.66395934382188
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/359	115/9376	0.22710427516047	GNG10	-1.66395934382188
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/359	116/9376	0.225146479684949	GNG10	-1.6755019568403
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	6/359	333/9376	0.470576426008181	PPP2R5A/ATP6V1G1/ISG15/TRADD/ATP6V1F/PARD6B	-1.96277697405733
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/359	122/9376	0.214073701995525	FXYD2	-1.74340712452274
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/359	122/9376	0.214073701995525	MAP2K6	-1.74340712452274
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/359	136/9376	0.192036703260691	TRADD	-1.89376867600413
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/359	143/9376	0.182636305198979	HLA-DMA	-1.96523175109677
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/359	148/9376	0.176466159753068	GADD45A	-2.01493175862138
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	5/359	362/9376	0.360731928776989	PRL/PPP2R5A/VEGFB/YWHAH/GNG10	-2.47502932987465
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/359	323/9376	0.242572677802979	MMP9/TGFB2/CYP24A1	-2.76406209778778
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/359	449/9376	0.116334038500909	CALM2/CALM1	-3.82877951084287