ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0015453 oxidoreduction-driven active transmembrane transporter activity 26/633 68/18639 0.382352941176471 11.2585726233621 4.42727721343918e-21 3.4355671176288e-18 GO:0015078 proton transmembrane transporter activity 37/633 185/18639 0.2 5.88909952606635 1.67216349873399e-18 6.48799437508789e-16 GO:0022853 active monoatomic ion transmembrane transporter activity 29/633 118/18639 0.245762711864407 7.2366053498273 2.50424325384983e-17 6.47764254995823e-15 GO:0009055 electron transfer activity 28/633 116/18639 0.241379310344828 7.10753391076973 1.48564579871329e-16 2.88215284950379e-14 GO:0008137 NADH dehydrogenase (ubiquinone) activity 17/633 41/18639 0.414634146341463 12.2091087735522 6.10585138985755e-15 9.47628135705892e-13 GO:0003954 NADH dehydrogenase activity 17/633 44/18639 0.386363636363636 11.3766695389918 2.51386533914795e-14 3.25126583863134e-12 GO:0015399 primary active transmembrane transporter activity 30/633 166/18639 0.180722891566265 5.32147547536116 5.2485216542461e-14 5.81836114813568e-12 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 18/633 58/18639 0.310344827586207 9.13825788527537 3.60324606647018e-13 3.49514868447607e-11 GO:0016651 oxidoreductase activity, acting on NAD(P)H 18/633 88/18639 0.204545454545455 6.02294269711331 7.48125556083967e-10 6.45050479467954e-08 GO:0003735 structural constituent of ribosome 22/633 175/18639 0.125714285714286 3.70171970209885 1.28305641051079e-07 9.95651774556369e-06 GO:0004129 cytochrome-c oxidase activity 7/633 15/18639 0.466666666666667 13.7412322274882 2.55822008682131e-07 1.80470798852122e-05 GO:0016675 oxidoreductase activity, acting on a heme group of donors 7/633 16/18639 0.4375 12.8824052132701 4.41471799484721e-07 2.85485097000119e-05 GO:0022804 active transmembrane transporter activity 36/633 457/18639 0.0787746170678337 2.31955780020119 2.72299243636764e-06 0.000162541702355483 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 6/633 18/18639 0.333333333333333 9.81516587677725 1.96136180244013e-05 0.00108715482763824 GO:0004602 glutathione peroxidase activity 6/633 23/18639 0.260869565217391 7.68143416443437 9.22497054271044e-05 0.00459156558991702 GO:0031386 protein tag activity 5/633 15/18639 0.333333333333333 9.81516587677725 0.000100588421428595 0.00459156558991702 GO:0141047 molecular tag activity 5/633 15/18639 0.333333333333333 9.81516587677725 0.000100588421428595 0.00459156558991702 GO:0016783 sulfurtransferase activity 4/633 10/18639 0.4 11.7781990521327 0.000234980179319199 0.00984057669125708 GO:0015252 proton channel activity 6/633 27/18639 0.222222222222222 6.5434439178515 0.000240941955069439 0.00984057669125708 GO:0048306 calcium-dependent protein binding 10/633 80/18639 0.125 3.68068720379147 0.000367924745834808 0.0142754801383905 GO:0004601 peroxidase activity 8/633 57/18639 0.140350877192982 4.13270142180095 0.000644038330999994 0.0232726960554572 GO:0016209 antioxidant activity 10/633 86/18639 0.116279069767442 3.42389507329439 0.000659792929407291 0.0232726960554572 GO:0019855 calcium channel inhibitor activity 4/633 13/18639 0.307692307692308 9.06015311702516 0.000737461649000682 0.0248813147662839 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 8/633 59/18639 0.135593220338983 3.99260984818058 0.000814460657213793 0.0263342279165793 GO:0044548 S100 protein binding 4/633 14/18639 0.285714285714286 8.41299932295193 0.00100485336387478 0.0311906484146733 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/633 15/18639 0.266666666666667 7.8521327014218 0.00133367697930976 0.039805128305553 GO:0004364 glutathione transferase activity 5/633 27/18639 0.185185185185185 5.45286993154292 0.00192964683231876 0.0554594793288651 GO:0098632 cell-cell adhesion mediator activity 7/633 55/18639 0.127272727272727 3.74760878931495 0.00248466955344227 0.0688608419096858 GO:0098641 cadherin binding involved in cell-cell adhesion 4/633 18/18639 0.222222222222222 6.5434439178515 0.00275723338466642 0.0737797622931427 GO:0003713 transcription coactivator activity 18/633 256/18639 0.0703125 2.0703865521327 0.00296894147277868 0.0767966194292086 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/633 33/18639 0.151515151515152 4.46143903489875 0.00479872897199389 0.120123022008621 GO:0060590 ATPase regulator activity 6/633 49/18639 0.122448979591837 3.60557113840797 0.00605680765758095 0.142602151616752 GO:0003712 transcription coregulator activity 28/633 495/18639 0.0565656565656566 1.6656039063622 0.00606426675689797 0.142602151616752 GO:0044325 transmembrane transporter binding 11/633 136/18639 0.0808823529411765 2.38162113186507 0.0067163635162838 0.153291120254007 GO:0016860 intramolecular oxidoreductase activity 6/633 53/18639 0.113207547169811 3.33345256192435 0.00887571649269857 0.196787314238117 GO:0050661 NADP binding 6/633 54/18639 0.111111111111111 3.27172195892575 0.00970611427345514 0.209220685450033 GO:0045296 cadherin binding 20/633 334/18639 0.0598802395209581 1.76320345091807 0.01051514675035 0.219036776374805 GO:0098847 sequence-specific single stranded DNA binding 3/633 14/18639 0.214285714285714 6.30974949221395 0.0107260277090755 0.219036776374805 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 10/633 128/18639 0.078125 2.30042950236967 0.0119790339711023 0.238352060553215 GO:0016846 carbon-sulfur lyase activity 3/633 15/18639 0.2 5.88909952606635 0.013074115391517 0.253637838595429 GO:0048487 beta-tubulin binding 5/633 42/18639 0.119047619047619 3.5054163845633 0.0134056236447101 0.253725949958415 GO:0098631 cell adhesion mediator activity 7/633 76/18639 0.0921052631578947 2.71208530805687 0.0145798032598935 0.266317042309626 GO:0008200 ion channel inhibitor activity 5/633 43/18639 0.116279069767442 3.42389507329439 0.0147572587877757 0.266317042309626 GO:0016248 channel inhibitor activity 5/633 44/18639 0.113636363636364 3.34607927617406 0.0161971958996662 0.285659636775931 GO:0141110 transporter inhibitor activity 5/633 45/18639 0.111111111111111 3.27172195892575 0.0177276333881453 0.302377688069457 GO:0043021 ribonucleoprotein complex binding 12/633 177/18639 0.0677966101694915 1.99630492409029 0.0179244505814369 0.302377688069457 GO:0017128 phospholipid scramblase activity 3/633 18/18639 0.166666666666667 4.90758293838863 0.0217472299742171 0.359060648084946 GO:0022884 macromolecule transmembrane transporter activity 4/633 32/18639 0.125 3.68068720379147 0.0222962487970646 0.360456022219211 GO:0051117 ATPase binding 7/633 84/18639 0.0833333333333333 2.45379146919431 0.0240183163899328 0.380371704460977 GO:0016782 transferase activity, transferring sulphur-containing groups 6/633 70/18639 0.0857142857142857 2.52389979688558 0.0314069248466256 0.47264246059787 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/633 36/18639 0.111111111111111 3.27172195892575 0.0328653905100536 0.47264246059787 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/633 36/18639 0.111111111111111 3.27172195892575 0.0328653905100536 0.47264246059787 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/633 36/18639 0.111111111111111 3.27172195892575 0.0328653905100536 0.47264246059787 GO:0072542 protein phosphatase activator activity 3/633 21/18639 0.142857142857143 4.20649966147596 0.0328900681343879 0.47264246059787 GO:0140313 molecular sequestering activity 5/633 55/18639 0.0909090909090909 2.67686342093925 0.0384032607192824 0.487560174028388 GO:0042562 hormone binding 7/633 94/18639 0.074468085106383 2.19274982353534 0.0408303556232366 0.487560174028388 GO:0005319 lipid transporter activity 11/633 178/18639 0.0617977528089888 1.81966558389691 0.0408515394967263 0.487560174028388 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/633 39/18639 0.102564102564103 3.02005103900839 0.0424158291613259 0.487560174028388 GO:0005345 purine nucleobase transmembrane transporter activity 2/633 10/18639 0.2 5.88909952606635 0.0432511694882137 0.487560174028388 GO:0005528 FK506 binding 2/633 10/18639 0.2 5.88909952606635 0.0432511694882137 0.487560174028388 GO:0019911 structural constituent of myelin sheath 2/633 10/18639 0.2 5.88909952606635 0.0432511694882137 0.487560174028388 GO:0031996 thioesterase binding 2/633 10/18639 0.2 5.88909952606635 0.0432511694882137 0.487560174028388 GO:0070513 death domain binding 2/633 10/18639 0.2 5.88909952606635 0.0432511694882137 0.487560174028388 GO:0016853 isomerase activity 11/633 180/18639 0.0611111111111111 1.79944707740916 0.0436938302054005 0.487560174028388 GO:0017022 myosin binding 6/633 76/18639 0.0789473684210526 2.32464454976303 0.0442998821147957 0.487560174028388 GO:0035035 histone acetyltransferase binding 3/633 24/18639 0.125 3.68068720379147 0.0464635657162776 0.487560174028388 GO:0005126 cytokine receptor binding 15/633 275/18639 0.0545454545454545 1.60611805256355 0.0491227441844054 0.487560174028388 GO:0017080 sodium channel regulator activity 4/633 41/18639 0.0975609756097561 2.87273147612993 0.0495620939570898 0.487560174028388 GO:0140318 protein transporter activity 4/633 41/18639 0.0975609756097561 2.87273147612993 0.0495620939570898 0.487560174028388 GO:0019211 phosphatase activator activity 3/633 25/18639 0.12 3.53345971563981 0.0515112569262708 0.487560174028388 GO:0120020 cholesterol transfer activity 3/633 25/18639 0.12 3.53345971563981 0.0515112569262708 0.487560174028388 GO:0010854 adenylate cyclase regulator activity 2/633 11/18639 0.181818181818182 5.3537268418785 0.0516969663290607 0.487560174028388 GO:0015205 nucleobase transmembrane transporter activity 2/633 11/18639 0.181818181818182 5.3537268418785 0.0516969663290607 0.487560174028388 GO:0050786 RAGE receptor binding 2/633 11/18639 0.181818181818182 5.3537268418785 0.0516969663290607 0.487560174028388 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 5/633 60/18639 0.0833333333333333 2.45379146919431 0.0526482075199996 0.487560174028388 GO:0016859 cis-trans isomerase activity 4/633 42/18639 0.0952380952380952 2.80433310765064 0.0533680382004983 0.487560174028388 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/633 61/18639 0.0819672131147541 2.41356537953539 0.0558201587389302 0.487560174028388 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/633 122/18639 0.0655737704918033 1.93085230362831 0.0562698300113132 0.487560174028388 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/633 26/18639 0.115384615384615 3.39755741888443 0.0568121804200715 0.487560174028388 GO:0033192 calmodulin-dependent protein phosphatase activity 6/633 81/18639 0.0740740740740741 2.18114797261717 0.0572455661141484 0.487560174028388 GO:0140791 histone H2AXS140 phosphatase activity 6/633 81/18639 0.0740740740740741 2.18114797261717 0.0572455661141484 0.487560174028388 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 6/633 81/18639 0.0740740740740741 2.18114797261717 0.0572455661141484 0.487560174028388 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 6/633 81/18639 0.0740740740740741 2.18114797261717 0.0572455661141484 0.487560174028388 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 6/633 81/18639 0.0740740740740741 2.18114797261717 0.0572455661141484 0.487560174028388 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 6/633 81/18639 0.0740740740740741 2.18114797261717 0.0572455661141484 0.487560174028388 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 6/633 81/18639 0.0740740740740741 2.18114797261717 0.0572455661141484 0.487560174028388 GO:1990439 MAP kinase serine/threonine phosphatase activity 6/633 81/18639 0.0740740740740741 2.18114797261717 0.0572455661141484 0.487560174028388 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 6/633 82/18639 0.0731707317073171 2.15454860709745 0.0600797019745506 0.487560174028388 GO:0033549 MAP kinase phosphatase activity 6/633 82/18639 0.0731707317073171 2.15454860709745 0.0600797019745506 0.487560174028388 GO:0000340 RNA 7-methylguanosine cap binding 2/633 12/18639 0.166666666666667 4.90758293838863 0.0606726430694085 0.487560174028388 GO:0005436 sodium:phosphate symporter activity 2/633 12/18639 0.166666666666667 4.90758293838863 0.0606726430694085 0.487560174028388 GO:0005527 macrolide binding 2/633 12/18639 0.166666666666667 4.90758293838863 0.0606726430694085 0.487560174028388 GO:0010853 cyclase activator activity 2/633 12/18639 0.166666666666667 4.90758293838863 0.0606726430694085 0.487560174028388 GO:0035259 nuclear glucocorticoid receptor binding 2/633 12/18639 0.166666666666667 4.90758293838863 0.0606726430694085 0.487560174028388 GO:0042301 phosphate ion binding 2/633 12/18639 0.166666666666667 4.90758293838863 0.0606726430694085 0.487560174028388 GO:0043047 single-stranded telomeric DNA binding 2/633 12/18639 0.166666666666667 4.90758293838863 0.0606726430694085 0.487560174028388 GO:0016247 channel regulator activity 10/633 168/18639 0.0595238095238095 1.75270819228165 0.0609450217535485 0.487560174028388 GO:0008320 protein transmembrane transporter activity 3/633 27/18639 0.111111111111111 3.27172195892575 0.0623604736983233 0.493786007743964 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 6/633 83/18639 0.072289156626506 2.12859019014446 0.062995895317851 0.493786007743964 GO:0141108 transporter regulator activity 10/633 170/18639 0.0588235294117647 1.73208809590187 0.0649231279044546 0.502073298050186 GO:0140303 intramembrane lipid transporter activity 4/633 45/18639 0.0888888888888889 2.6173775671406 0.0657059495815127 0.502073298050186 GO:0017018 myosin phosphatase activity 6/633 84/18639 0.0714285714285714 2.10324983073798 0.0659941706199987 0.502073298050186 GO:0031432 titin binding 2/633 13/18639 0.153846153846154 4.53007655851258 0.0701325929146068 0.508625159829298 GO:0035673 oligopeptide transmembrane transporter activity 2/633 13/18639 0.153846153846154 4.53007655851258 0.0701325929146068 0.508625159829298 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/633 13/18639 0.153846153846154 4.53007655851258 0.0701325929146068 0.508625159829298 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/633 13/18639 0.153846153846154 4.53007655851258 0.0701325929146068 0.508625159829298 GO:0089720 caspase binding 2/633 13/18639 0.153846153846154 4.53007655851258 0.0701325929146068 0.508625159829298 GO:0043495 protein-membrane adaptor activity 4/633 47/18639 0.0851063829787234 2.50599979832611 0.0746837672030693 0.536616697681312 GO:0033218 amide binding 13/633 247/18639 0.0526315789473684 1.54976303317536 0.0793605847123642 0.54674433782696 GO:0016829 lyase activity 11/633 200/18639 0.055 1.61950236966825 0.0797395741275402 0.54674433782696 GO:0016530 metallochaperone activity 2/633 14/18639 0.142857142857143 4.20649966147596 0.0800336871155287 0.54674433782696 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 8/633 132/18639 0.0606060606060606 1.7845756139595 0.080902292635593 0.54674433782696 GO:0003777 microtubule motor activity 5/633 68/18639 0.0735294117647059 2.16511011987733 0.0810252562501294 0.54674433782696 GO:0005548 phospholipid transporter activity 5/633 68/18639 0.0735294117647059 2.16511011987733 0.0810252562501294 0.54674433782696 GO:0032934 sterol binding 5/633 68/18639 0.0735294117647059 2.16511011987733 0.0810252562501294 0.54674433782696 GO:0061134 peptidase regulator activity 12/633 226/18639 0.0530973451327434 1.5634777502831 0.0850017317894783 0.568632274729613 GO:0005164 tumor necrosis factor receptor binding 3/633 31/18639 0.0967741935483871 2.8495642868063 0.0868947312147411 0.569919381449104 GO:0043022 ribosome binding 7/633 112/18639 0.0625 1.84034360189573 0.087043491121977 0.569919381449104 GO:0003714 transcription corepressor activity 11/633 204/18639 0.053921568627451 1.58774742124338 0.0886809775339722 0.569919381449104 GO:0008017 microtubule binding 14/633 276/18639 0.0507246376811594 1.49361219864002 0.0889588493027987 0.569919381449104 GO:0032813 tumor necrosis factor receptor superfamily binding 4/633 50/18639 0.08 2.35563981042654 0.0892410814159987 0.569919381449104 GO:0000774 adenyl-nucleotide exchange factor activity 2/633 15/18639 0.133333333333333 3.9260663507109 0.0903351596884534 0.569919381449104 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/633 15/18639 0.133333333333333 3.9260663507109 0.0903351596884534 0.569919381449104 GO:0031625 ubiquitin protein ligase binding 15/633 302/18639 0.0496688741721854 1.46252471673833 0.0920264945634761 0.571779608559567 GO:0002020 protease binding 8/633 136/18639 0.0588235294117647 1.73208809590187 0.0922970127869577 0.571779608559567 GO:0043425 bHLH transcription factor binding 3/633 32/18639 0.09375 2.7605154028436 0.093577332844156 0.571779608559567 GO:0120015 sterol transfer activity 3/633 32/18639 0.09375 2.7605154028436 0.093577332844156 0.571779608559567 GO:0099106 ion channel regulator activity 9/633 160/18639 0.05625 1.65630924170616 0.0955368971980097 0.579192439262934 GO:0061135 endopeptidase regulator activity 10/633 184/18639 0.0543478260869565 1.60029878425716 0.0973745162631611 0.584886818954295 GO:0140311 protein sequestering activity 3/633 33/18639 0.0909090909090909 2.67686342093925 0.10046409614783 0.584886818954295 GO:0005521 lamin binding 2/633 16/18639 0.125 3.68068720379147 0.100998497087468 0.584886818954295 GO:0008142 oxysterol binding 2/633 16/18639 0.125 3.68068720379147 0.100998497087468 0.584886818954295 GO:0017070 U6 snRNA binding 2/633 16/18639 0.125 3.68068720379147 0.100998497087468 0.584886818954295 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/633 16/18639 0.125 3.68068720379147 0.100998497087468 0.584886818954295 GO:0004867 serine-type endopeptidase inhibitor activity 6/633 95/18639 0.0631578947368421 1.85971563981043 0.104330686838271 0.591171225295116 GO:0005246 calcium channel regulator activity 4/633 53/18639 0.0754716981132075 2.22230170794957 0.105048605364562 0.591171225295116 GO:0140296 general transcription initiation factor binding 4/633 53/18639 0.0754716981132075 2.22230170794957 0.105048605364562 0.591171225295116 GO:0015020 glucuronosyltransferase activity 3/633 34/18639 0.0882352941176471 2.5981321438528 0.107546936379468 0.591171225295116 GO:0015631 tubulin binding 18/633 385/18639 0.0467532467532468 1.37667261648304 0.107584446895933 0.591171225295116 GO:0015485 cholesterol binding 4/633 54/18639 0.0740740740740741 2.18114797261717 0.110582508484611 0.591171225295116 GO:0051287 NAD binding 4/633 54/18639 0.0740740740740741 2.18114797261717 0.110582508484611 0.591171225295116 GO:0019003 GDP binding 5/633 75/18639 0.0666666666666667 1.96303317535545 0.111312034437314 0.591171225295116 GO:0004549 tRNA-specific ribonuclease activity 2/633 17/18639 0.117647058823529 3.46417619180374 0.111987332626781 0.591171225295116 GO:0008429 phosphatidylethanolamine binding 2/633 17/18639 0.117647058823529 3.46417619180374 0.111987332626781 0.591171225295116 GO:0031489 myosin V binding 2/633 17/18639 0.117647058823529 3.46417619180374 0.111987332626781 0.591171225295116 GO:0032977 membrane insertase activity 2/633 17/18639 0.117647058823529 3.46417619180374 0.111987332626781 0.591171225295116 GO:0070402 NADPH binding 2/633 17/18639 0.117647058823529 3.46417619180374 0.111987332626781 0.591171225295116 GO:0003697 single-stranded DNA binding 7/633 121/18639 0.0578512396694215 1.7034585405977 0.118073711549348 0.617132000488262 GO:0005484 SNAP receptor activity 3/633 36/18639 0.0833333333333333 2.45379146919431 0.122267829290648 0.617132000488262 GO:0045505 dynein intermediate chain binding 3/633 36/18639 0.0833333333333333 2.45379146919431 0.122267829290648 0.617132000488262 GO:0030414 peptidase inhibitor activity 9/633 169/18639 0.0532544378698225 1.56810342410051 0.122389340682894 0.617132000488262 GO:0000400 four-way junction DNA binding 2/633 18/18639 0.111111111111111 3.27172195892575 0.123267345458351 0.617132000488262 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/633 18/18639 0.111111111111111 3.27172195892575 0.123267345458351 0.617132000488262 GO:0050811 GABA receptor binding 2/633 18/18639 0.111111111111111 3.27172195892575 0.123267345458351 0.617132000488262 GO:0070628 proteasome binding 2/633 18/18639 0.111111111111111 3.27172195892575 0.123267345458351 0.617132000488262 GO:0019209 kinase activator activity 8/633 148/18639 0.0540540540540541 1.59164852055847 0.131659279362595 0.653451416313828 GO:0008301 DNA binding, bending 2/633 19/18639 0.105263157894737 3.09952606635071 0.134806163917963 0.653451416313828 GO:0016918 retinal binding 2/633 19/18639 0.105263157894737 3.09952606635071 0.134806163917963 0.653451416313828 GO:0042577 lipid phosphatase activity 2/633 19/18639 0.105263157894737 3.09952606635071 0.134806163917963 0.653451416313828 GO:0097001 ceramide binding 2/633 19/18639 0.105263157894737 3.09952606635071 0.134806163917963 0.653451416313828 GO:0044389 ubiquitin-like protein ligase binding 15/633 322/18639 0.046583850931677 1.37168467222042 0.135574327353771 0.653451416313828 GO:0042887 amide transmembrane transporter activity 3/633 38/18639 0.0789473684210526 2.32464454976303 0.137673078100012 0.657452797722961 GO:0004722 protein serine/threonine phosphatase activity 6/633 103/18639 0.058252427184466 1.71527170662127 0.138098976841292 0.657452797722961 GO:0004879 nuclear receptor activity 4/633 59/18639 0.0677966101694915 1.99630492409029 0.140093204207988 0.662880039423162 GO:0001618 virus receptor activity 5/633 81/18639 0.0617283950617284 1.81762331051431 0.140996988562152 0.66311310984382 GO:0140272 exogenous protein binding 5/633 82/18639 0.0609756097560976 1.7954571725812 0.146251357821088 0.665151227454701 GO:0098531 ligand-modulated transcription factor activity 4/633 60/18639 0.0666666666666667 1.96303317535545 0.146339275399987 0.665151227454701 GO:0000339 RNA cap binding 2/633 20/18639 0.1 2.94454976303318 0.14657327306025 0.665151227454701 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/633 20/18639 0.1 2.94454976303318 0.14657327306025 0.665151227454701 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/633 20/18639 0.1 2.94454976303318 0.14657327306025 0.665151227454701 GO:0010851 cyclase regulator activity 2/633 20/18639 0.1 2.94454976303318 0.14657327306025 0.665151227454701 GO:0001540 amyloid-beta binding 5/633 83/18639 0.0602409638554217 1.77382515845372 0.15158824644309 0.675655559954755 GO:0019905 syntaxin binding 4/633 61/18639 0.0655737704918033 1.93085230362831 0.152691494113044 0.675655559954755 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/633 40/18639 0.075 2.20841232227488 0.153694968114216 0.675655559954755 GO:0071855 neuropeptide receptor binding 3/633 40/18639 0.075 2.20841232227488 0.153694968114216 0.675655559954755 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7/633 130/18639 0.0538461538461538 1.5855267954794 0.154061890899647 0.675655559954755 GO:0005506 iron ion binding 8/633 154/18639 0.051948051948052 1.52963624053671 0.154112157360814 0.675655559954755 GO:0019888 protein phosphatase regulator activity 6/633 107/18639 0.0560747663551402 1.65114939983169 0.156677872362328 0.683045106478465 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/633 21/18639 0.0952380952380952 2.80433310765064 0.15853992621034 0.683483237440134 GO:0070182 DNA polymerase binding 2/633 21/18639 0.0952380952380952 2.80433310765064 0.15853992621034 0.683483237440134 GO:0005496 steroid binding 6/633 108/18639 0.0555555555555556 1.63586097946288 0.16148628894664 0.692339006754657 GO:0042056 chemoattractant activity 3/633 42/18639 0.0714285714285714 2.10324983073798 0.170265826517699 0.712080380884304 GO:0008970 phospholipase A1 activity 2/633 22/18639 0.0909090909090909 2.67686342093925 0.170679060366599 0.712080380884304 GO:0034062 5'-3' RNA polymerase activity 2/633 22/18639 0.0909090909090909 2.67686342093925 0.170679060366599 0.712080380884304 GO:0061133 endopeptidase activator activity 2/633 22/18639 0.0909090909090909 2.67686342093925 0.170679060366599 0.712080380884304 GO:0097747 RNA polymerase activity 2/633 22/18639 0.0909090909090909 2.67686342093925 0.170679060366599 0.712080380884304 GO:0005125 cytokine activity 11/633 234/18639 0.047008547008547 1.38419005954551 0.174075935877987 0.722368589525765 GO:0120013 lipid transfer activity 4/633 65/18639 0.0615384615384615 1.81203062340503 0.179085562067593 0.739204234917297 GO:0004866 endopeptidase inhibitor activity 8/633 161/18639 0.0496894409937888 1.46313031703512 0.182438427017138 0.747268458259722 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/633 23/18639 0.0869565217391304 2.56047805481146 0.18296521529555 0.747268458259722 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/633 67/18639 0.0597014925373134 1.75794015703473 0.192819167416317 0.764322320712367 GO:0030295 protein kinase activator activity 7/633 139/18639 0.0503597122302158 1.48286678713901 0.194463506764339 0.764322320712367 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/633 24/18639 0.0833333333333333 2.45379146919431 0.195374456166393 0.764322320712367 GO:0005315 phosphate transmembrane transporter activity 2/633 24/18639 0.0833333333333333 2.45379146919431 0.195374456166393 0.764322320712367 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/633 24/18639 0.0833333333333333 2.45379146919431 0.195374456166393 0.764322320712367 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/633 24/18639 0.0833333333333333 2.45379146919431 0.195374456166393 0.764322320712367 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/633 24/18639 0.0833333333333333 2.45379146919431 0.195374456166393 0.764322320712367 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/633 24/18639 0.0833333333333333 2.45379146919431 0.195374456166393 0.764322320712367 GO:0046915 transition metal ion transmembrane transporter activity 3/633 45/18639 0.0666666666666667 1.96303317535545 0.196005337399177 0.764322320712367 GO:0043178 alcohol binding 5/633 92/18639 0.0543478260869565 1.60029878425716 0.202979116579979 0.783098138218332 GO:0019208 phosphatase regulator activity 6/633 117/18639 0.0512820512820513 1.51002551950419 0.207416893082669 0.783098138218332 GO:0003707 nuclear steroid receptor activity 2/633 25/18639 0.08 2.35563981042654 0.207884299578578 0.783098138218332 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/633 25/18639 0.08 2.35563981042654 0.207884299578578 0.783098138218332 GO:0017025 TBP-class protein binding 2/633 25/18639 0.08 2.35563981042654 0.207884299578578 0.783098138218332 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/633 25/18639 0.08 2.35563981042654 0.207884299578578 0.783098138218332 GO:0019707 protein-cysteine S-acyltransferase activity 2/633 25/18639 0.08 2.35563981042654 0.207884299578578 0.783098138218332 GO:0016410 N-acyltransferase activity 5/633 94/18639 0.0531914893617021 1.56624987395382 0.215120630345115 0.806442556269611 GO:0019955 cytokine binding 7/633 144/18639 0.0486111111111111 1.43137835703002 0.218555263217575 0.814702604024888 GO:0008157 protein phosphatase 1 binding 2/633 26/18639 0.0769230769230769 2.26503827925629 0.220473642841787 0.814702604024888 GO:0008198 ferrous iron binding 2/633 26/18639 0.0769230769230769 2.26503827925629 0.220473642841787 0.814702604024888 GO:0140297 DNA-binding transcription factor binding 20/633 488/18639 0.040983606557377 1.20678268976769 0.224060825330031 0.824034125384378 GO:0004896 cytokine receptor activity 5/633 96/18639 0.0520833333333333 1.53361966824645 0.227483569681525 0.832060184749427 GO:0042379 chemokine receptor binding 4/633 72/18639 0.0555555555555556 1.63586097946288 0.228464040729184 0.832060184749427 GO:0001671 ATPase activator activity 2/633 27/18639 0.0740740740740741 2.18114797261717 0.233122696373264 0.832060184749427 GO:0005385 zinc ion transmembrane transporter activity 2/633 27/18639 0.0740740740740741 2.18114797261717 0.233122696373264 0.832060184749427 GO:0008395 steroid hydroxylase activity 2/633 27/18639 0.0740740740740741 2.18114797261717 0.233122696373264 0.832060184749427 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/633 27/18639 0.0740740740740741 2.18114797261717 0.233122696373264 0.832060184749427 GO:0004521 RNA endonuclease activity 4/633 73/18639 0.0547945205479452 1.61345192494969 0.235785953826926 0.832060184749427 GO:0046625 sphingolipid binding 2/633 28/18639 0.0714285714285714 2.10324983073798 0.245812919082839 0.832060184749427 GO:0051537 2 iron, 2 sulfur cluster binding 2/633 28/18639 0.0714285714285714 2.10324983073798 0.245812919082839 0.832060184749427 GO:0097718 disordered domain specific binding 2/633 28/18639 0.0714285714285714 2.10324983073798 0.245812919082839 0.832060184749427 GO:0051536 iron-sulfur cluster binding 4/633 76/18639 0.0526315789473684 1.54976303317536 0.258066749020032 0.832060184749427 GO:0003785 actin monomer binding 2/633 29/18639 0.0689655172413793 2.03072397450564 0.258526956621191 0.832060184749427 GO:0016417 S-acyltransferase activity 2/633 29/18639 0.0689655172413793 2.03072397450564 0.258526956621191 0.832060184749427 GO:0051861 glycolipid binding 2/633 29/18639 0.0689655172413793 2.03072397450564 0.258526956621191 0.832060184749427 GO:0051540 metal cluster binding 4/633 77/18639 0.051948051948052 1.52963624053671 0.265585802711142 0.832060184749427 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/633 30/18639 0.0666666666666667 1.96303317535545 0.27124858237186 0.832060184749427 GO:0031210 phosphatidylcholine binding 2/633 30/18639 0.0666666666666667 1.96303317535545 0.27124858237186 0.832060184749427 GO:0035591 signaling adaptor activity 6/633 129/18639 0.0465116279069767 1.36955802931776 0.274660951201867 0.832060184749427 GO:0003925 G protein activity 3/633 54/18639 0.0555555555555556 1.63586097946288 0.27758547390243 0.832060184749427 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/633 54/18639 0.0555555555555556 1.63586097946288 0.27758547390243 0.832060184749427 GO:0017069 snRNA binding 3/633 54/18639 0.0555555555555556 1.63586097946288 0.27758547390243 0.832060184749427 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/633 54/18639 0.0555555555555556 1.63586097946288 0.27758547390243 0.832060184749427 GO:0046332 SMAD binding 4/633 79/18639 0.0506329113924051 1.49091127242186 0.280739267314639 0.832060184749427 GO:0005184 neuropeptide hormone activity 2/633 31/18639 0.0645161290322581 1.89970952453753 0.283962641072351 0.832060184749427 GO:0008327 methyl-CpG binding 2/633 31/18639 0.0645161290322581 1.89970952453753 0.283962641072351 0.832060184749427 GO:0047499 calcium-independent phospholipase A2 activity 2/633 31/18639 0.0645161290322581 1.89970952453753 0.283962641072351 0.832060184749427 GO:0000149 SNARE binding 5/633 106/18639 0.0471698113207547 1.38893856746848 0.291941530412335 0.832060184749427 GO:0001094 TFIID-class transcription factor complex binding 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0004935 adrenergic receptor activity 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0004955 prostaglandin receptor activity 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0005337 nucleoside transmembrane transporter activity 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0005381 iron ion transmembrane transporter activity 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0008401 retinoic acid 4-hydroxylase activity 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0030957 Tat protein binding 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0032052 bile acid binding 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0033204 ribonuclease P RNA binding 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0043121 neurotrophin binding 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0043295 glutathione binding 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0043422 protein kinase B binding 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0047429 nucleoside triphosphate diphosphatase activity 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0097177 mitochondrial ribosome binding 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0098505 G-rich strand telomeric DNA binding 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0141109 transporter activator activity 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:1990757 ubiquitin ligase activator activity 1/633 10/18639 0.1 2.94454976303318 0.29220172225426 0.832060184749427 GO:0030971 receptor tyrosine kinase binding 4/633 81/18639 0.0493827160493827 1.45409864841144 0.296021765521324 0.832060184749427 GO:0030515 snoRNA binding 2/633 32/18639 0.0625 1.84034360189573 0.296654994954231 0.832060184749427 GO:0047498 calcium-dependent phospholipase A2 activity 2/633 32/18639 0.0625 1.84034360189573 0.296654994954231 0.832060184749427 GO:0160041 neuropeptide activity 2/633 32/18639 0.0625 1.84034360189573 0.296654994954231 0.832060184749427 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 14/633 349/18639 0.0401146131805158 1.18119474734855 0.299702635145898 0.832060184749427 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 11/633 268/18639 0.041044776119403 1.20858385796138 0.303406383240394 0.832060184749427 GO:0051087 protein-folding chaperone binding 6/633 134/18639 0.0447761194029851 1.31845511777605 0.304099724329257 0.832060184749427 GO:0016504 peptidase activator activity 3/633 57/18639 0.0526315789473684 1.54976303317536 0.3055751557305 0.832060184749427 GO:0019239 deaminase activity 2/633 33/18639 0.0606060606060606 1.7845756139595 0.309312472296579 0.832060184749427 GO:0019956 chemokine binding 2/633 33/18639 0.0606060606060606 1.7845756139595 0.309312472296579 0.832060184749427 GO:0030296 protein tyrosine kinase activator activity 2/633 33/18639 0.0606060606060606 1.7845756139595 0.309312472296579 0.832060184749427 GO:0140416 transcription regulator inhibitor activity 2/633 33/18639 0.0606060606060606 1.7845756139595 0.309312472296579 0.832060184749427 GO:0140789 histone phosphatase activity 6/633 136/18639 0.0441176470588235 1.2990660719264 0.316034995465154 0.832060184749427 GO:0003953 NAD+ nucleosidase activity 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0004954 prostanoid receptor activity 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0005114 type II transforming growth factor beta receptor binding 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0008199 ferric iron binding 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0008503 benzodiazepine receptor activity 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0015173 aromatic amino acid transmembrane transporter activity 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0019107 myristoyltransferase activity 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0019206 nucleoside kinase activity 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0031731 CCR6 chemokine receptor binding 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0032794 GTPase activating protein binding 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0034056 estrogen response element binding 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0034511 U3 snoRNA binding 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0045294 alpha-catenin binding 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0070990 snRNP binding 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0097493 structural molecule activity conferring elasticity 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:1900750 oligopeptide binding 1/633 11/18639 0.0909090909090909 2.67686342093925 0.31625219784678 0.832060184749427 GO:0019902 phosphatase binding 8/633 190/18639 0.0421052631578947 1.23981042654028 0.318475806114049 0.832060184749427 GO:0008376 acetylgalactosaminyltransferase activity 2/633 34/18639 0.0588235294117647 1.73208809590187 0.321922818291398 0.832060184749427 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/633 34/18639 0.0588235294117647 1.73208809590187 0.321922818291398 0.832060184749427 GO:0016831 carboxy-lyase activity 2/633 34/18639 0.0588235294117647 1.73208809590187 0.321922818291398 0.832060184749427 GO:0019825 oxygen binding 2/633 34/18639 0.0588235294117647 1.73208809590187 0.321922818291398 0.832060184749427 GO:0016922 nuclear receptor binding 6/633 137/18639 0.0437956204379562 1.28958383782475 0.322030244695512 0.832060184749427 GO:0004623 phospholipase A2 activity 2/633 35/18639 0.0571428571428571 1.68259986459039 0.334474648123669 0.832060184749427 GO:0005154 epidermal growth factor receptor binding 2/633 35/18639 0.0571428571428571 1.68259986459039 0.334474648123669 0.832060184749427 GO:0016229 steroid dehydrogenase activity 2/633 35/18639 0.0571428571428571 1.68259986459039 0.334474648123669 0.832060184749427 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/633 86/18639 0.0465116279069767 1.36955802931776 0.334604310347302 0.832060184749427 GO:0003779 actin binding 17/633 443/18639 0.0383747178329571 1.12996266301499 0.337392605746996 0.832060184749427 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0003995 acyl-CoA dehydrogenase activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0004000 adenosine deaminase activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0004032 aldose reductase (NADPH) activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0004126 cytidine deaminase activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0004300 enoyl-CoA hydratase activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0004526 ribonuclease P activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0004859 phospholipase inhibitor activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0008179 adenylate cyclase binding 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0015166 polyol transmembrane transporter activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0016801 hydrolase activity, acting on ether bonds 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0016803 ether hydrolase activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0016840 carbon-nitrogen lyase activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0035197 siRNA binding 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0070008 serine-type exopeptidase activity 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0070410 co-SMAD binding 1/633 12/18639 0.0833333333333333 2.45379146919431 0.339486702826541 0.832060184749427 GO:0016874 ligase activity 7/633 167/18639 0.0419161676646707 1.23424241564265 0.339900874440165 0.832060184749427 GO:0016836 hydro-lyase activity 3/633 61/18639 0.0491803278688525 1.44813922772123 0.343030147493445 0.835892600697523 GO:0001217 DNA-binding transcription repressor activity 11/633 278/18639 0.039568345323741 1.16510961846636 0.345644995066362 0.835892600697523 GO:0004033 aldo-keto reductase (NADPH) activity 2/633 36/18639 0.0555555555555556 1.63586097946288 0.34695740217267 0.835892600697523 GO:0016409 palmitoyltransferase activity 2/633 36/18639 0.0555555555555556 1.63586097946288 0.34695740217267 0.835892600697523 GO:0020037 heme binding 6/633 142/18639 0.0422535211267606 1.2441759562112 0.352217678886887 0.835892600697523 GO:0001221 transcription coregulator binding 5/633 115/18639 0.0434782608695652 1.28023902740573 0.352291098034469 0.835892600697523 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/633 89/18639 0.0449438202247191 1.32339315192502 0.357875593698085 0.835892600697523 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/633 89/18639 0.0449438202247191 1.32339315192502 0.357875593698085 0.835892600697523 GO:0015294 solute:monoatomic cation symporter activity 5/633 116/18639 0.0431034482758621 1.26920248406602 0.359056674206177 0.835892600697523 GO:0019213 deacetylase activity 2/633 37/18639 0.0540540540540541 1.59164852055847 0.359361303244957 0.835892600697523 GO:0030280 structural constituent of skin epidermis 2/633 37/18639 0.0540540540540541 1.59164852055847 0.359361303244957 0.835892600697523 GO:0005507 copper ion binding 3/633 63/18639 0.0476190476190476 1.40216655382532 0.36171423329071 0.835892600697523 GO:0005172 vascular endothelial growth factor receptor binding 1/633 13/18639 0.0769230769230769 2.26503827925629 0.361932878652536 0.835892600697523 GO:0008035 high-density lipoprotein particle binding 1/633 13/18639 0.0769230769230769 2.26503827925629 0.361932878652536 0.835892600697523 GO:0031994 insulin-like growth factor I binding 1/633 13/18639 0.0769230769230769 2.26503827925629 0.361932878652536 0.835892600697523 GO:0071837 HMG box domain binding 1/633 13/18639 0.0769230769230769 2.26503827925629 0.361932878652536 0.835892600697523 GO:0140333 glycerophospholipid flippase activity 1/633 13/18639 0.0769230769230769 2.26503827925629 0.361932878652536 0.835892600697523 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/633 13/18639 0.0769230769230769 2.26503827925629 0.361932878652536 0.835892600697523 GO:1901338 catecholamine binding 1/633 13/18639 0.0769230769230769 2.26503827925629 0.361932878652536 0.835892600697523 GO:0140793 histone H2AXY142 phosphatase activity 4/633 90/18639 0.0444444444444444 1.3086887835703 0.36563361279075 0.837743568806261 GO:0005501 retinoid binding 2/633 38/18639 0.0526315789473684 1.54976303317536 0.371677315753009 0.837743568806261 GO:0019840 isoprenoid binding 2/633 38/18639 0.0526315789473684 1.54976303317536 0.371677315753009 0.837743568806261 GO:0042162 telomeric DNA binding 2/633 38/18639 0.0526315789473684 1.54976303317536 0.371677315753009 0.837743568806261 GO:0019843 rRNA binding 3/633 65/18639 0.0461538461538462 1.35902296755377 0.38031488259101 0.837743568806261 GO:0008195 phosphatidate phosphatase activity 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0008474 palmitoyl-(protein) hydrolase activity 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0008494 translation activator activity 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0019992 diacylglycerol binding 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0032036 myosin heavy chain binding 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0034236 protein kinase A catalytic subunit binding 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0042043 neurexin family protein binding 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0070742 C2H2 zinc finger domain binding 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0098599 palmitoyl hydrolase activity 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:1901474 azole transmembrane transporter activity 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:1901612 cardiolipin binding 1/633 14/18639 0.0714285714285714 2.10324983073798 0.38361743184769 0.837743568806261 GO:0000217 DNA secondary structure binding 2/633 39/18639 0.0512820512820513 1.51002551950419 0.383897106757051 0.837743568806261 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/633 39/18639 0.0512820512820513 1.51002551950419 0.383897106757051 0.837743568806261 GO:0004721 phosphoprotein phosphatase activity 7/633 175/18639 0.04 1.17781990521327 0.384325657854419 0.837743568806261 GO:0004540 RNA nuclease activity 5/633 121/18639 0.0413223140495868 1.21675610042693 0.392904372959349 0.845865514980126 GO:0015036 disulfide oxidoreductase activity 2/633 40/18639 0.05 1.47227488151659 0.396013008790884 0.845865514980126 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/633 40/18639 0.05 1.47227488151659 0.396013008790884 0.845865514980126 GO:0050997 quaternary ammonium group binding 2/633 40/18639 0.05 1.47227488151659 0.396013008790884 0.845865514980126 GO:0004953 icosanoid receptor activity 1/633 15/18639 0.0666666666666667 1.96303317535545 0.40456616557335 0.845865514980126 GO:0005523 tropomyosin binding 1/633 15/18639 0.0666666666666667 1.96303317535545 0.40456616557335 0.845865514980126 GO:0008020 G protein-coupled photoreceptor activity 1/633 15/18639 0.0666666666666667 1.96303317535545 0.40456616557335 0.845865514980126 GO:0015250 water channel activity 1/633 15/18639 0.0666666666666667 1.96303317535545 0.40456616557335 0.845865514980126 GO:0017081 chloride channel regulator activity 1/633 15/18639 0.0666666666666667 1.96303317535545 0.40456616557335 0.845865514980126 GO:0034483 heparan sulfate sulfotransferase activity 1/633 15/18639 0.0666666666666667 1.96303317535545 0.40456616557335 0.845865514980126 GO:0048531 beta-1,3-galactosyltransferase activity 1/633 15/18639 0.0666666666666667 1.96303317535545 0.40456616557335 0.845865514980126 GO:0050700 CARD domain binding 1/633 15/18639 0.0666666666666667 1.96303317535545 0.40456616557335 0.845865514980126 GO:0120283 protein serine/threonine kinase binding 1/633 15/18639 0.0666666666666667 1.96303317535545 0.40456616557335 0.845865514980126 GO:0046906 tetrapyrrole binding 6/633 152/18639 0.0394736842105263 1.16232227488152 0.413024640550436 0.845865514980126 GO:0051015 actin filament binding 8/633 209/18639 0.0382775119617225 1.12710038776389 0.416156740933544 0.845865514980126 GO:0003774 cytoskeletal motor activity 6/633 153/18639 0.0392156862745098 1.15472539726791 0.419093444326237 0.845865514980126 GO:0031492 nucleosomal DNA binding 2/633 42/18639 0.0476190476190476 1.40216655382532 0.419905592289705 0.845865514980126 GO:0051879 Hsp90 protein binding 2/633 42/18639 0.0476190476190476 1.40216655382532 0.419905592289705 0.845865514980126 GO:0005543 phospholipid binding 18/633 497/18639 0.0362173038229376 1.06643653389532 0.423868174752194 0.845865514980126 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0004708 MAP kinase kinase activity 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0005159 insulin-like growth factor receptor binding 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0016722 oxidoreductase activity, acting on metal ions 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0019841 retinol binding 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0030275 LRR domain binding 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0034450 ubiquitin-ubiquitin ligase activity 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0043023 ribosomal large subunit binding 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0055102 lipase inhibitor activity 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0070411 I-SMAD binding 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0097027 ubiquitin-protein transferase activator activity 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0140327 flippase activity 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0140328 floppase activity 1/633 16/18639 0.0625 1.84034360189573 0.424804010139075 0.845865514980126 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/633 70/18639 0.0428571428571429 1.26194989844279 0.426215398834081 0.845865514980126 GO:0004725 protein tyrosine phosphatase activity 4/633 98/18639 0.0408163265306122 1.20185704613599 0.427292889010579 0.845865514980126 GO:0042626 ATPase-coupled transmembrane transporter activity 4/633 98/18639 0.0408163265306122 1.20185704613599 0.427292889010579 0.845865514980126 GO:0008375 acetylglucosaminyltransferase activity 2/633 43/18639 0.0465116279069767 1.36955802931776 0.431669955101592 0.847839997990739 GO:0005539 glycosaminoglycan binding 9/633 242/18639 0.0371900826446281 1.09508049038424 0.438618865974366 0.847839997990739 GO:0016790 thiolester hydrolase activity 2/633 44/18639 0.0454545454545455 1.33843171046963 0.443305728604303 0.847839997990739 GO:0004857 enzyme inhibitor activity 15/633 416/18639 0.0360576923076923 1.06173669340139 0.443441723029781 0.847839997990739 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/633 17/18639 0.0588235294117647 1.73208809590187 0.444355052483594 0.847839997990739 GO:0005092 GDP-dissociation inhibitor activity 1/633 17/18639 0.0588235294117647 1.73208809590187 0.444355052483594 0.847839997990739 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/633 17/18639 0.0588235294117647 1.73208809590187 0.444355052483594 0.847839997990739 GO:0009881 photoreceptor activity 1/633 17/18639 0.0588235294117647 1.73208809590187 0.444355052483594 0.847839997990739 GO:0015278 intracellularly gated calcium channel activity 1/633 17/18639 0.0588235294117647 1.73208809590187 0.444355052483594 0.847839997990739 GO:0016018 cyclosporin A binding 1/633 17/18639 0.0588235294117647 1.73208809590187 0.444355052483594 0.847839997990739 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/633 17/18639 0.0588235294117647 1.73208809590187 0.444355052483594 0.847839997990739 GO:0048038 quinone binding 1/633 17/18639 0.0588235294117647 1.73208809590187 0.444355052483594 0.847839997990739 GO:0070403 NAD+ binding 1/633 17/18639 0.0588235294117647 1.73208809590187 0.444355052483594 0.847839997990739 GO:0016791 phosphatase activity 10/633 273/18639 0.0366300366300366 1.07858965678871 0.449138212571664 0.847839997990739 GO:0043539 protein serine/threonine kinase activator activity 3/633 73/18639 0.0410958904109589 1.21008894371226 0.453185507842714 0.847839997990739 GO:0008009 chemokine activity 2/633 45/18639 0.0444444444444444 1.3086887835703 0.454808072381286 0.847839997990739 GO:0051539 4 iron, 4 sulfur cluster binding 2/633 45/18639 0.0444444444444444 1.3086887835703 0.454808072381286 0.847839997990739 GO:0003684 damaged DNA binding 3/633 74/18639 0.0405405405405405 1.19373639041885 0.462059699498885 0.847839997990739 GO:0000900 mRNA regulatory element binding translation repressor activity 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0005372 water transmembrane transporter activity 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0008308 voltage-gated monoatomic anion channel activity 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0016854 racemase and epimerase activity 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0017075 syntaxin-1 binding 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0022851 GABA-gated chloride ion channel activity 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0030228 lipoprotein particle receptor activity 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0031690 adrenergic receptor binding 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0035615 clathrin adaptor activity 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0070064 proline-rich region binding 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:1901611 phosphatidylglycerol binding 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:1990381 ubiquitin-specific protease binding 1/633 18/18639 0.0555555555555556 1.63586097946288 0.463242564661549 0.847839997990739 GO:0005253 monoatomic anion channel activity 4/633 103/18639 0.0388349514563107 1.14351447108084 0.465068493061325 0.847839997990739 GO:0004180 carboxypeptidase activity 2/633 46/18639 0.0434782608695652 1.28023902740573 0.466172621865683 0.847839997990739 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/633 46/18639 0.0434782608695652 1.28023902740573 0.466172621865683 0.847839997990739 GO:0005179 hormone activity 5/633 132/18639 0.0378787878787879 1.11535975872469 0.466530514358306 0.847839997990739 GO:0008083 growth factor activity 6/633 162/18639 0.037037037037037 1.09057398630858 0.473208715506565 0.849171564415346 GO:0001784 phosphotyrosine residue binding 2/633 47/18639 0.0425531914893617 1.25299989916305 0.477395461692599 0.849171564415346 GO:0005504 fatty acid binding 2/633 47/18639 0.0425531914893617 1.25299989916305 0.477395461692599 0.849171564415346 GO:0003756 protein disulfide isomerase activity 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0004890 GABA-A receptor activity 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0005520 insulin-like growth factor binding 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0008381 mechanosensitive monoatomic ion channel activity 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0015245 fatty acid transmembrane transporter activity 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0031420 alkali metal ion binding 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0042834 peptidoglycan binding 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0046624 sphingolipid transporter activity 1/633 19/18639 0.0526315789473684 1.54976303317536 0.481489031369526 0.849171564415346 GO:0004497 monooxygenase activity 4/633 106/18639 0.0377358490566038 1.11115085397478 0.487306206262641 0.857482122584602 GO:0005326 neurotransmitter transmembrane transporter activity 1/633 20/18639 0.05 1.47227488151659 0.499116176543698 0.86503637929503 GO:0016505 peptidase activator activity involved in apoptotic process 1/633 20/18639 0.05 1.47227488151659 0.499116176543698 0.86503637929503 GO:0043024 ribosomal small subunit binding 1/633 20/18639 0.05 1.47227488151659 0.499116176543698 0.86503637929503 GO:0052745 inositol phosphate phosphatase activity 1/633 20/18639 0.05 1.47227488151659 0.499116176543698 0.86503637929503 GO:0001222 transcription corepressor binding 2/633 49/18639 0.0408163265306122 1.20185704613599 0.499402445778574 0.86503637929503 GO:0016763 pentosyltransferase activity 2/633 49/18639 0.0408163265306122 1.20185704613599 0.499402445778574 0.86503637929503 GO:0035254 glutamate receptor binding 2/633 49/18639 0.0408163265306122 1.20185704613599 0.499402445778574 0.86503637929503 GO:0015370 solute:sodium symporter activity 3/633 79/18639 0.0379746835443038 1.1181834543164 0.505431743555152 0.86862596433699 GO:0016835 carbon-oxygen lyase activity 3/633 79/18639 0.0379746835443038 1.1181834543164 0.505431743555152 0.86862596433699 GO:0033293 monocarboxylic acid binding 3/633 79/18639 0.0379746835443038 1.1181834543164 0.505431743555152 0.86862596433699 GO:0005201 extracellular matrix structural constituent 6/633 168/18639 0.0357142857142857 1.05162491536899 0.508493297740249 0.86862596433699 GO:0019207 kinase regulator activity 10/633 287/18639 0.0348432055749129 1.02597552718926 0.512394716282892 0.86862596433699 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/633 21/18639 0.0476190476190476 1.40216655382532 0.516144989060366 0.86862596433699 GO:0005123 death receptor binding 1/633 21/18639 0.0476190476190476 1.40216655382532 0.516144989060366 0.86862596433699 GO:0008373 sialyltransferase activity 1/633 21/18639 0.0476190476190476 1.40216655382532 0.516144989060366 0.86862596433699 GO:0015174 basic amino acid transmembrane transporter activity 1/633 21/18639 0.0476190476190476 1.40216655382532 0.516144989060366 0.86862596433699 GO:0036122 BMP binding 1/633 21/18639 0.0476190476190476 1.40216655382532 0.516144989060366 0.86862596433699 GO:0140312 cargo adaptor activity 1/633 21/18639 0.0476190476190476 1.40216655382532 0.516144989060366 0.86862596433699 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 8/633 229/18639 0.0349344978165939 1.02866367267535 0.518107164652924 0.86862596433699 GO:0003743 translation initiation factor activity 2/633 51/18639 0.0392156862745098 1.15472539726791 0.52080575052706 0.86862596433699 GO:0016830 carbon-carbon lyase activity 2/633 51/18639 0.0392156862745098 1.15472539726791 0.52080575052706 0.86862596433699 GO:0005085 guanyl-nucleotide exchange factor activity 8/633 230/18639 0.0347826086956522 1.02419122192458 0.523068673721123 0.86862596433699 GO:1902936 phosphatidylinositol bisphosphate binding 4/633 111/18639 0.036036036036036 1.06109901370565 0.523491984499248 0.86862596433699 GO:0005080 protein kinase C binding 2/633 52/18639 0.0384615384615385 1.13251913962814 0.531275322144327 0.86862596433699 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/633 52/18639 0.0384615384615385 1.13251913962814 0.531275322144327 0.86862596433699 GO:0030159 signaling receptor complex adaptor activity 2/633 52/18639 0.0384615384615385 1.13251913962814 0.531275322144327 0.86862596433699 GO:0008201 heparin binding 6/633 172/18639 0.0348837209302326 1.02716852198832 0.531528188924681 0.86862596433699 GO:0008093 cytoskeletal anchor activity 1/633 22/18639 0.0454545454545455 1.33843171046963 0.532595747569593 0.86862596433699 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/633 22/18639 0.0454545454545455 1.33843171046963 0.532595747569593 0.86862596433699 GO:0016881 acid-amino acid ligase activity 1/633 22/18639 0.0454545454545455 1.33843171046963 0.532595747569593 0.86862596433699 GO:0050321 tau-protein kinase activity 1/633 22/18639 0.0454545454545455 1.33843171046963 0.532595747569593 0.86862596433699 GO:0070034 telomerase RNA binding 1/633 22/18639 0.0454545454545455 1.33843171046963 0.532595747569593 0.86862596433699 GO:0140784 metal ion sensor activity 1/633 22/18639 0.0454545454545455 1.33843171046963 0.532595747569593 0.86862596433699 GO:0005254 chloride channel activity 3/633 83/18639 0.036144578313253 1.06429509507223 0.538786972856464 0.86862596433699 GO:0004864 protein phosphatase inhibitor activity 2/633 53/18639 0.0377358490566038 1.11115085397478 0.541587784527273 0.86862596433699 GO:0005544 calcium-dependent phospholipid binding 2/633 53/18639 0.0377358490566038 1.11115085397478 0.541587784527273 0.86862596433699 GO:0017046 peptide hormone binding 2/633 53/18639 0.0377358490566038 1.11115085397478 0.541587784527273 0.86862596433699 GO:0034212 protein N-acetyltransferase activity 2/633 53/18639 0.0377358490566038 1.11115085397478 0.541587784527273 0.86862596433699 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/633 53/18639 0.0377358490566038 1.11115085397478 0.541587784527273 0.86862596433699 GO:0003887 DNA-directed DNA polymerase activity 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0005212 structural constituent of eye lens 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0008171 O-methyltransferase activity 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0016493 C-C chemokine receptor activity 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0016917 GABA receptor activity 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0017134 fibroblast growth factor binding 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0031681 G-protein beta-subunit binding 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0042171 lysophosphatidic acid acyltransferase activity 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0071617 lysophospholipid acyltransferase activity 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0140103 catalytic activity, acting on a glycoprotein 1/633 23/18639 0.0434782608695652 1.28023902740573 0.548488044491141 0.86862596433699 GO:0008194 UDP-glycosyltransferase activity 5/633 145/18639 0.0344827586206897 1.01536198725282 0.549612259748326 0.868633632514667 GO:0015293 symporter activity 5/633 146/18639 0.0342465753424658 1.00840745309355 0.55575007024658 0.874382698376812 GO:0001664 G protein-coupled receptor binding 10/633 297/18639 0.0336700336700337 0.991430896644167 0.55623676407899 0.874382698376812 GO:0016757 glycosyltransferase activity 9/633 267/18639 0.0337078651685393 0.992544863943767 0.556630222935754 0.874382698376812 GO:0004622 lysophospholipase activity 1/633 24/18639 0.0416666666666667 1.22689573459716 0.563840809200912 0.875080935879816 GO:0015295 solute:proton symporter activity 1/633 24/18639 0.0416666666666667 1.22689573459716 0.563840809200912 0.875080935879816 GO:0019957 C-C chemokine binding 1/633 24/18639 0.0416666666666667 1.22689573459716 0.563840809200912 0.875080935879816 GO:0048027 mRNA 5'-UTR binding 1/633 24/18639 0.0416666666666667 1.22689573459716 0.563840809200912 0.875080935879816 GO:0050699 WW domain binding 1/633 24/18639 0.0416666666666667 1.22689573459716 0.563840809200912 0.875080935879816 GO:0070300 phosphatidic acid binding 1/633 24/18639 0.0416666666666667 1.22689573459716 0.563840809200912 0.875080935879816 GO:1990782 protein tyrosine kinase binding 4/633 117/18639 0.0341880341880342 1.00668367966946 0.56522822759416 0.875483242740655 GO:0019212 phosphatase inhibitor activity 2/633 56/18639 0.0357142857142857 1.05162491536899 0.571569702675167 0.881785465757316 GO:0170055 lipid transmembrane transporter activity 2/633 56/18639 0.0357142857142857 1.05162491536899 0.571569702675167 0.881785465757316 GO:0051082 unfolded protein binding 4/633 121/18639 0.0330578512396694 0.973404880341545 0.591905053157386 0.897014065654182 GO:0001637 G protein-coupled chemoattractant receptor activity 1/633 26/18639 0.0384615384615385 1.13251913962814 0.593000277938912 0.897014065654182 GO:0004950 chemokine receptor activity 1/633 26/18639 0.0384615384615385 1.13251913962814 0.593000277938912 0.897014065654182 GO:0005112 Notch binding 1/633 26/18639 0.0384615384615385 1.13251913962814 0.593000277938912 0.897014065654182 GO:0005160 transforming growth factor beta receptor binding 1/633 26/18639 0.0384615384615385 1.13251913962814 0.593000277938912 0.897014065654182 GO:0030507 spectrin binding 1/633 26/18639 0.0384615384615385 1.13251913962814 0.593000277938912 0.897014065654182 GO:0051139 metal cation:proton antiporter activity 1/633 26/18639 0.0384615384615385 1.13251913962814 0.593000277938912 0.897014065654182 GO:0070412 R-SMAD binding 1/633 26/18639 0.0384615384615385 1.13251913962814 0.593000277938912 0.897014065654182 GO:0097602 cullin family protein binding 1/633 26/18639 0.0384615384615385 1.13251913962814 0.593000277938912 0.897014065654182 GO:0120014 phospholipid transfer activity 1/633 26/18639 0.0384615384615385 1.13251913962814 0.593000277938912 0.897014065654182 GO:0001786 phosphatidylserine binding 2/633 59/18639 0.0338983050847458 0.998152462045144 0.600102301204672 0.900733821537381 GO:0031593 polyubiquitin modification-dependent protein binding 2/633 59/18639 0.0338983050847458 0.998152462045144 0.600102301204672 0.900733821537381 GO:0045309 protein phosphorylated amino acid binding 2/633 59/18639 0.0338983050847458 0.998152462045144 0.600102301204672 0.900733821537381 GO:0070888 E-box binding 2/633 59/18639 0.0338983050847458 0.998152462045144 0.600102301204672 0.900733821537381 GO:0072341 modified amino acid binding 3/633 91/18639 0.032967032967033 0.970730691109838 0.6014335727114 0.900989290393912 GO:0023026 MHC class II protein complex binding 1/633 27/18639 0.037037037037037 1.09057398630858 0.606841723383744 0.902306807678089 GO:0035255 ionotropic glutamate receptor binding 1/633 27/18639 0.037037037037037 1.09057398630858 0.606841723383744 0.902306807678089 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/633 27/18639 0.037037037037037 1.09057398630858 0.606841723383744 0.902306807678089 GO:0052689 carboxylic ester hydrolase activity 3/633 92/18639 0.0326086956521739 0.960179270554296 0.608859440937475 0.902306807678089 GO:0001098 basal transcription machinery binding 2/633 60/18639 0.0333333333333333 0.981516587677725 0.609289648483658 0.902306807678089 GO:0001099 basal RNA polymerase II transcription machinery binding 2/633 60/18639 0.0333333333333333 0.981516587677725 0.609289648483658 0.902306807678089 GO:0042277 peptide binding 8/633 249/18639 0.0321285140562249 0.946040084508651 0.613284252817687 0.904671828214544 GO:0140375 immune receptor activity 5/633 156/18639 0.032051282051282 0.94376594969012 0.614715935574131 0.904671828214544 GO:0019789 SUMO transferase activity 1/633 28/18639 0.0357142857142857 1.05162491536899 0.620213160580074 0.904671828214544 GO:0036408 histone H3K14 acetyltransferase activity 1/633 28/18639 0.0357142857142857 1.05162491536899 0.620213160580074 0.904671828214544 GO:0045499 chemorepellent activity 1/633 28/18639 0.0357142857142857 1.05162491536899 0.620213160580074 0.904671828214544 GO:0046966 nuclear thyroid hormone receptor binding 1/633 28/18639 0.0357142857142857 1.05162491536899 0.620213160580074 0.904671828214544 GO:0050698 proteoglycan sulfotransferase activity 1/633 28/18639 0.0357142857142857 1.05162491536899 0.620213160580074 0.904671828214544 GO:0051959 dynein light intermediate chain binding 1/633 28/18639 0.0357142857142857 1.05162491536899 0.620213160580074 0.904671828214544 GO:0004519 endonuclease activity 4/633 127/18639 0.031496062992126 0.927417248199425 0.63005151253383 0.913214288857936 GO:0004181 metallocarboxypeptidase activity 1/633 29/18639 0.0344827586206897 1.01536198725282 0.633130525007177 0.913214288857936 GO:0010484 histone H3 acetyltransferase activity 1/633 29/18639 0.0344827586206897 1.01536198725282 0.633130525007177 0.913214288857936 GO:0035250 UDP-galactosyltransferase activity 1/633 29/18639 0.0344827586206897 1.01536198725282 0.633130525007177 0.913214288857936 GO:0099604 ligand-gated calcium channel activity 1/633 29/18639 0.0344827586206897 1.01536198725282 0.633130525007177 0.913214288857936 GO:0106222 lncRNA binding 1/633 29/18639 0.0344827586206897 1.01536198725282 0.633130525007177 0.913214288857936 GO:0019887 protein kinase regulator activity 8/633 255/18639 0.0313725490196078 0.92378031781433 0.639863751082825 0.915891680151706 GO:0005178 integrin binding 5/633 161/18639 0.031055900621118 0.914456448146949 0.642416216474799 0.915891680151706 GO:0001965 G-protein alpha-subunit binding 1/633 30/18639 0.0333333333333333 0.981516587677725 0.645609212684257 0.915891680151706 GO:0001968 fibronectin binding 1/633 30/18639 0.0333333333333333 0.981516587677725 0.645609212684257 0.915891680151706 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/633 30/18639 0.0333333333333333 0.981516587677725 0.645609212684257 0.915891680151706 GO:0016769 transferase activity, transferring nitrogenous groups 1/633 30/18639 0.0333333333333333 0.981516587677725 0.645609212684257 0.915891680151706 GO:0043995 histone H4K5 acetyltransferase activity 1/633 30/18639 0.0333333333333333 0.981516587677725 0.645609212684257 0.915891680151706 GO:0043996 histone H4K8 acetyltransferase activity 1/633 30/18639 0.0333333333333333 0.981516587677725 0.645609212684257 0.915891680151706 GO:0043997 histone H4K12 acetyltransferase activity 1/633 30/18639 0.0333333333333333 0.981516587677725 0.645609212684257 0.915891680151706 GO:0008236 serine-type peptidase activity 6/633 194/18639 0.0309278350515464 0.910685493721601 0.648773765851304 0.918701537044913 GO:0160215 deacylase activity 2/633 65/18639 0.0307692307692308 0.906015311702515 0.652811971676528 0.922529686328991 GO:0016411 acylglycerol O-acyltransferase activity 1/633 31/18639 0.032258064516129 0.949854762268766 0.657664098404654 0.922529686328991 GO:0070325 lipoprotein particle receptor binding 1/633 31/18639 0.032258064516129 0.949854762268766 0.657664098404654 0.922529686328991 GO:0072349 modified amino acid transmembrane transporter activity 1/633 31/18639 0.032258064516129 0.949854762268766 0.657664098404654 0.922529686328991 GO:0015103 inorganic anion transmembrane transporter activity 5/633 165/18639 0.0303030303030303 0.89228780697975 0.663661774703964 0.922529686328991 GO:0043130 ubiquitin binding 3/633 100/18639 0.03 0.883364928909953 0.664886424492293 0.922529686328991 GO:0017171 serine hydrolase activity 6/633 198/18639 0.0303030303030303 0.89228780697975 0.668070673455221 0.922529686328991 GO:0000287 magnesium ion binding 7/633 230/18639 0.0304347826086957 0.89616731918401 0.6684443938019 0.922529686328991 GO:0008378 galactosyltransferase activity 1/633 32/18639 0.03125 0.920171800947867 0.669309553354667 0.922529686328991 GO:0015106 bicarbonate transmembrane transporter activity 1/633 32/18639 0.03125 0.920171800947867 0.669309553354667 0.922529686328991 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/633 32/18639 0.03125 0.920171800947867 0.669309553354667 0.922529686328991 GO:0042910 xenobiotic transmembrane transporter activity 1/633 32/18639 0.03125 0.920171800947867 0.669309553354667 0.922529686328991 GO:0051059 NF-kappaB binding 1/633 32/18639 0.03125 0.920171800947867 0.669309553354667 0.922529686328991 GO:0071813 lipoprotein particle binding 1/633 32/18639 0.03125 0.920171800947867 0.669309553354667 0.922529686328991 GO:0071814 protein-lipid complex binding 1/633 32/18639 0.03125 0.920171800947867 0.669309553354667 0.922529686328991 GO:0030145 manganese ion binding 2/633 68/18639 0.0294117647058824 0.866044047950934 0.677020209292621 0.929854305152343 GO:0140223 general transcription initiation factor activity 2/633 68/18639 0.0294117647058824 0.866044047950934 0.677020209292621 0.929854305152343 GO:0019838 growth factor binding 4/633 136/18639 0.0294117647058824 0.866044047950934 0.682818663343261 0.936161276951185 GO:0008080 N-acetyltransferase activity 2/633 69/18639 0.0289855072463768 0.853492684937152 0.684778409352779 0.937192320384051 GO:0003924 GTPase activity 10/633 331/18639 0.0302114803625378 0.88959207342392 0.69117247249819 0.93767777684664 GO:0015035 protein-disulfide reductase activity 1/633 34/18639 0.0294117647058824 0.866044047950934 0.691427239223985 0.93767777684664 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/633 34/18639 0.0294117647058824 0.866044047950934 0.691427239223985 0.93767777684664 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/633 34/18639 0.0294117647058824 0.866044047950934 0.691427239223985 0.93767777684664 GO:0090482 vitamin transmembrane transporter activity 1/633 34/18639 0.0294117647058824 0.866044047950934 0.691427239223985 0.93767777684664 GO:0097110 scaffold protein binding 2/633 70/18639 0.0285714285714286 0.841299932295193 0.6923832037798 0.93767777684664 GO:0140299 molecular sensor activity 2/633 71/18639 0.028169014084507 0.829450637474134 0.699836046073628 0.943713855058965 GO:0010485 histone H4 acetyltransferase activity 1/633 35/18639 0.0285714285714286 0.841299932295193 0.701925844844583 0.943713855058965 GO:0034061 DNA polymerase activity 1/633 35/18639 0.0285714285714286 0.841299932295193 0.701925844844583 0.943713855058965 GO:0043015 gamma-tubulin binding 1/633 35/18639 0.0285714285714286 0.841299932295193 0.701925844844583 0.943713855058965 GO:0008013 beta-catenin binding 3/633 106/18639 0.0283018867924528 0.833363140481087 0.702920886886704 0.943713855058965 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/633 36/18639 0.0277777777777778 0.817930489731438 0.712067800349495 0.94943626705822 GO:0055106 ubiquitin-protein transferase regulator activity 1/633 36/18639 0.0277777777777778 0.817930489731438 0.712067800349495 0.94943626705822 GO:0046982 protein heterodimerization activity 11/633 369/18639 0.029810298102981 0.877779062150811 0.712508667917259 0.94943626705822 GO:0004518 nuclease activity 6/633 209/18639 0.0287081339712919 0.845325290822921 0.717577463567828 0.94943626705822 GO:0004252 serine-type endopeptidase activity 5/633 176/18639 0.0284090909090909 0.836519819043516 0.717737384249753 0.94943626705822 GO:1901681 sulfur compound binding 8/633 275/18639 0.0290909090909091 0.85659629470056 0.72056324232472 0.94943626705822 GO:0004620 phospholipase activity 3/633 109/18639 0.0275229357798165 0.81042654028436 0.720664893451385 0.94943626705822 GO:0031491 nucleosome binding 2/633 74/18639 0.027027027027027 0.795824260279237 0.72129852728885 0.94943626705822 GO:0022829 wide pore channel activity 1/633 37/18639 0.027027027027027 0.795824260279237 0.721865203046843 0.94943626705822 GO:0023023 MHC protein complex binding 1/633 37/18639 0.027027027027027 0.795824260279237 0.721865203046843 0.94943626705822 GO:0030551 cyclic nucleotide binding 1/633 37/18639 0.027027027027027 0.795824260279237 0.721865203046843 0.94943626705822 GO:0043394 proteoglycan binding 1/633 37/18639 0.027027027027027 0.795824260279237 0.721865203046843 0.94943626705822 GO:0003725 double-stranded RNA binding 2/633 75/18639 0.0266666666666667 0.78521327014218 0.728159558523181 0.954479421307412 GO:0044183 protein folding chaperone 2/633 75/18639 0.0266666666666667 0.78521327014218 0.728159558523181 0.954479421307412 GO:0000146 microfilament motor activity 1/633 38/18639 0.0263157894736842 0.774881516587678 0.731329740541271 0.955407203131357 GO:0043531 ADP binding 1/633 38/18639 0.0263157894736842 0.774881516587678 0.731329740541271 0.955407203131357 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 5/633 181/18639 0.0276243093922652 0.813411536749496 0.740176102064611 0.964105400604801 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/633 39/18639 0.0256410256410256 0.755012759752096 0.740472704588224 0.964105400604801 GO:0004532 RNA exonuclease activity 1/633 40/18639 0.025 0.736137440758294 0.749305004480463 0.967502863639142 GO:0015144 carbohydrate transmembrane transporter activity 1/633 40/18639 0.025 0.736137440758294 0.749305004480463 0.967502863639142 GO:0030331 nuclear estrogen receptor binding 1/633 40/18639 0.025 0.736137440758294 0.749305004480463 0.967502863639142 GO:0071949 FAD binding 1/633 40/18639 0.025 0.736137440758294 0.749305004480463 0.967502863639142 GO:0008509 monoatomic anion transmembrane transporter activity 4/633 149/18639 0.0268456375838926 0.790483157861255 0.749316006504026 0.967502863639142 GO:0001530 lipopolysaccharide binding 1/633 41/18639 0.024390243902439 0.718182869032482 0.75783717998258 0.972035787878483 GO:0001727 lipid kinase activity 1/633 41/18639 0.024390243902439 0.718182869032482 0.75783717998258 0.972035787878483 GO:0008227 G protein-coupled amine receptor activity 1/633 41/18639 0.024390243902439 0.718182869032482 0.75783717998258 0.972035787878483 GO:0140828 metal cation:monoatomic cation antiporter activity 1/633 41/18639 0.024390243902439 0.718182869032482 0.75783717998258 0.972035787878483 GO:0000049 tRNA binding 2/633 80/18639 0.025 0.736137440758294 0.760347154000413 0.973645860568186 GO:0031406 carboxylic acid binding 5/633 187/18639 0.0267379679144385 0.787312770864485 0.765342549253821 0.977759251860375 GO:0004402 histone acetyltransferase activity 1/633 42/18639 0.0238095238095238 0.701083276912661 0.766079413828748 0.977759251860375 GO:0043177 organic acid binding 5/633 189/18639 0.0264550264550265 0.778981418791845 0.773309607241631 0.980853362177614 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/633 43/18639 0.0232558139534884 0.684779014658878 0.774041543798442 0.980853362177614 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/633 43/18639 0.0232558139534884 0.684779014658878 0.774041543798442 0.980853362177614 GO:0048156 tau protein binding 1/633 43/18639 0.0232558139534884 0.684779014658878 0.774041543798442 0.980853362177614 GO:0008135 translation factor activity, RNA binding 2/633 83/18639 0.0240963855421687 0.709530063381488 0.778034622851823 0.980853362177614 GO:0030165 PDZ domain binding 2/633 83/18639 0.0240963855421687 0.709530063381488 0.778034622851823 0.980853362177614 GO:0032182 ubiquitin-like protein binding 3/633 120/18639 0.025 0.736137440758294 0.778704117466066 0.980853362177614 GO:0001046 core promoter sequence-specific DNA binding 1/633 44/18639 0.0227272727272727 0.669215855234813 0.781733074384352 0.980853362177614 GO:0019205 nucleobase-containing compound kinase activity 1/633 44/18639 0.0227272727272727 0.669215855234813 0.781733074384352 0.980853362177614 GO:0043014 alpha-tubulin binding 1/633 44/18639 0.0227272727272727 0.669215855234813 0.781733074384352 0.980853362177614 GO:0015108 chloride transmembrane transporter activity 3/633 121/18639 0.0247933884297521 0.730053660256159 0.783453246219677 0.980853362177614 GO:0180051 translation factor activity 2/633 84/18639 0.0238095238095238 0.701083276912661 0.783671500708918 0.980853362177614 GO:0042605 peptide antigen binding 1/633 45/18639 0.0222222222222222 0.65434439178515 0.78916318806624 0.98613628653688 GO:0042578 phosphoric ester hydrolase activity 10/633 363/18639 0.0275482093663912 0.811170733617955 0.792298512879748 0.988462453367659 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/633 46/18639 0.0217391304347826 0.640119513702864 0.79634075620403 0.990321196817833 GO:0030291 protein serine/threonine kinase inhibitor activity 1/633 46/18639 0.0217391304347826 0.640119513702864 0.79634075620403 0.990321196817833 GO:0016758 hexosyltransferase activity 5/633 197/18639 0.0253807106598985 0.747347655592177 0.803116653665323 0.992581043409026 GO:0061733 protein-lysine-acetyltransferase activity 1/633 47/18639 0.0212765957446809 0.626499949581527 0.803274349562974 0.992581043409026 GO:0099095 ligand-gated monoatomic anion channel activity 1/633 47/18639 0.0212765957446809 0.626499949581527 0.803274349562974 0.992581043409026 GO:0140359 ABC-type transporter activity 1/633 47/18639 0.0212765957446809 0.626499949581527 0.803274349562974 0.992581043409026 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/633 48/18639 0.0208333333333333 0.613447867298578 0.809972248483297 0.997680102893712 GO:0038187 pattern recognition receptor activity 1/633 48/18639 0.0208333333333333 0.613447867298578 0.809972248483297 0.997680102893712 GO:0031490 chromatin DNA binding 3/633 128/18639 0.0234375 0.6901288507109 0.814381511986938 0.999991843059779 GO:0019210 kinase inhibitor activity 2/633 90/18639 0.0222222222222222 0.65434439178515 0.814916712038391 0.999991843059779 GO:0016298 lipase activity 3/633 130/18639 0.0230769230769231 0.679511483776887 0.822501232608491 0.999991843059779 GO:0048020 CCR chemokine receptor binding 1/633 50/18639 0.02 0.588909952606635 0.822692690868598 0.999991843059779 GO:0031072 heat shock protein binding 3/633 131/18639 0.0229007633587786 0.674324373213704 0.826446338652767 0.999991843059779 GO:0005048 signal sequence binding 1/633 51/18639 0.0196078431372549 0.577362698633956 0.828730429675429 0.999991843059779 GO:0016597 amino acid binding 1/633 51/18639 0.0196078431372549 0.577362698633956 0.828730429675429 0.999991843059779 GO:0030544 Hsp70 protein binding 1/633 51/18639 0.0196078431372549 0.577362698633956 0.828730429675429 0.999991843059779 GO:0051213 dioxygenase activity 2/633 93/18639 0.021505376344086 0.633236508179178 0.828975728507746 0.999991843059779 GO:0051219 phosphoprotein binding 2/633 93/18639 0.021505376344086 0.633236508179178 0.828975728507746 0.999991843059779 GO:0005516 calmodulin binding 5/633 207/18639 0.0241545893719807 0.711243904114294 0.83591942599905 0.999991843059779 GO:0005216 monoatomic ion channel activity 12/633 448/18639 0.0267857142857143 0.788718686526743 0.836781340396366 0.999991843059779 GO:0004842 ubiquitin-protein transferase activity 12/633 449/18639 0.0267260579064588 0.786962074752742 0.838889750395365 0.999991843059779 GO:0008146 sulfotransferase activity 1/633 53/18639 0.0188679245283019 0.555575426987392 0.840197019268832 0.999991843059779 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/633 53/18639 0.0188679245283019 0.555575426987392 0.840197019268832 0.999991843059779 GO:0051018 protein kinase A binding 1/633 53/18639 0.0188679245283019 0.555575426987392 0.840197019268832 0.999991843059779 GO:0016407 acetyltransferase activity 2/633 96/18639 0.0208333333333333 0.613447867298578 0.842065878603308 0.999991843059779 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 13/633 484/18639 0.0268595041322314 0.790891465277506 0.842144944594807 0.999991843059779 GO:0051020 GTPase binding 8/633 315/18639 0.0253968253968254 0.747822162040171 0.84300754963638 0.999991843059779 GO:0016779 nucleotidyltransferase activity 3/633 136/18639 0.0220588235294118 0.6495330359632 0.845063460855305 0.999991843059779 GO:0140463 chromatin-protein adaptor activity 1/633 54/18639 0.0185185185185185 0.545286993154292 0.845639572093691 0.999991843059779 GO:0030594 neurotransmitter receptor activity 2/633 97/18639 0.0206185567010309 0.607123662481067 0.846223348950156 0.999991843059779 GO:0008374 O-acyltransferase activity 1/633 55/18639 0.0181818181818182 0.53537268418785 0.850897045909386 0.999991843059779 GO:0061630 ubiquitin protein ligase activity 9/633 353/18639 0.0254957507082153 0.750735067062283 0.851190753860235 0.999991843059779 GO:0030695 GTPase regulator activity 13/633 489/18639 0.0265848670756646 0.782804640479167 0.851895737846116 0.999991843059779 GO:0060589 nucleoside-triphosphatase regulator activity 13/633 490/18639 0.026530612244898 0.781207079988393 0.853788992168397 0.999991843059779 GO:0070851 growth factor receptor binding 3/633 139/18639 0.0215827338129496 0.63551433734529 0.855382686673554 0.999991843059779 GO:0001216 DNA-binding transcription activator activity 13/633 491/18639 0.0264765784114053 0.779616026872327 0.855663475490838 0.999991843059779 GO:0030170 pyridoxal phosphate binding 1/633 56/18639 0.0178571428571429 0.525812457684496 0.855975724877281 0.999991843059779 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/633 57/18639 0.0175438596491228 0.516587677725118 0.860881680113394 0.999991843059779 GO:0070279 vitamin B6 binding 1/633 57/18639 0.0175438596491228 0.516587677725118 0.860881680113394 0.999991843059779 GO:0008238 exopeptidase activity 2/633 102/18639 0.0196078431372549 0.577362698633956 0.86555488946784 0.999991843059779 GO:0061980 regulatory RNA binding 1/633 58/18639 0.0172413793103448 0.50768099362641 0.865620776899973 0.999991843059779 GO:0019903 protein phosphatase binding 3/633 144/18639 0.0208333333333333 0.613447867298578 0.871249411916744 0.999991843059779 GO:1901981 phosphatidylinositol phosphate binding 4/633 185/18639 0.0216216216216216 0.636659408223389 0.877889033467872 0.999991843059779 GO:0015026 coreceptor activity 1/633 61/18639 0.0163934426229508 0.482713075907078 0.878892626562488 0.999991843059779 GO:0015179 L-amino acid transmembrane transporter activity 1/633 62/18639 0.0161290322580645 0.474927381134383 0.883019064682089 0.999991843059779 GO:0046943 carboxylic acid transmembrane transporter activity 4/633 188/18639 0.0212765957446809 0.626499949581527 0.885437817545366 0.999991843059779 GO:0022824 transmitter-gated monoatomic ion channel activity 1/633 63/18639 0.0158730158730159 0.467388851275107 0.887005119053421 0.999991843059779 GO:0022835 transmitter-gated channel activity 1/633 63/18639 0.0158730158730159 0.467388851275107 0.887005119053421 0.999991843059779 GO:1901682 sulfur compound transmembrane transporter activity 1/633 63/18639 0.0158730158730159 0.467388851275107 0.887005119053421 0.999991843059779 GO:0005342 organic acid transmembrane transporter activity 4/633 189/18639 0.0211640211640212 0.623185135033476 0.887862211281663 0.999991843059779 GO:0019842 vitamin binding 3/633 150/18639 0.02 0.588909952606635 0.888244369843152 0.999991843059779 GO:0061659 ubiquitin-like protein ligase activity 9/633 372/18639 0.0241935483870968 0.712391071701575 0.888838437889873 0.999991843059779 GO:0019787 ubiquitin-like protein transferase activity 12/633 479/18639 0.0250521920668058 0.737674262137747 0.892897052644606 0.999991843059779 GO:0038024 cargo receptor activity 1/633 65/18639 0.0153846153846154 0.453007655851258 0.894574989351638 0.999991843059779 GO:0005200 structural constituent of cytoskeleton 2/633 112/18639 0.0178571428571429 0.525812457684496 0.897688553029974 0.999991843059779 GO:0008514 organic anion transmembrane transporter activity 6/633 269/18639 0.0223048327137546 0.656776898817809 0.898021861358787 0.999991843059779 GO:0008235 metalloexopeptidase activity 1/633 66/18639 0.0151515151515152 0.446143903489875 0.898167862816719 0.999991843059779 GO:0016500 protein-hormone receptor activity 1/633 67/18639 0.0149253731343284 0.439485039258683 0.901638478378934 0.999991843059779 GO:0050840 extracellular matrix binding 1/633 67/18639 0.0149253731343284 0.439485039258683 0.901638478378934 0.999991843059779 GO:1990841 promoter-specific chromatin binding 1/633 68/18639 0.0147058823529412 0.433022023975467 0.904990989857834 0.999991843059779 GO:0002039 p53 binding 1/633 69/18639 0.0144927536231884 0.426746342468576 0.908229410159379 0.999991843059779 GO:0016755 aminoacyltransferase activity 12/633 496/18639 0.0241935483870968 0.712391071701575 0.916286706803659 0.999991843059779 GO:0005518 collagen binding 1/633 72/18639 0.0138888888888889 0.408965244865719 0.917298238464137 0.999991843059779 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/633 73/18639 0.0136986301369863 0.403362981237421 0.920117768547199 0.999991843059779 GO:0015081 sodium ion transmembrane transporter activity 3/633 164/18639 0.0182926829268293 0.538637151774361 0.920338859366655 0.999991843059779 GO:0031267 small GTPase binding 6/633 283/18639 0.0212014134275618 0.624286168840956 0.921862943609464 0.999991843059779 GO:0035064 methylated histone binding 1/633 74/18639 0.0135135135135135 0.397912130139618 0.922841319797313 0.999991843059779 GO:0048029 monosaccharide binding 1/633 74/18639 0.0135135135135135 0.397912130139618 0.922841319797313 0.999991843059779 GO:0035091 phosphatidylinositol binding 6/633 284/18639 0.0211267605633803 0.6220879781056 0.9233627979374 0.999991843059779 GO:0015291 secondary active transmembrane transporter activity 6/633 287/18639 0.0209059233449477 0.615585316313556 0.927712045619967 0.999991843059779 GO:0140034 methylation-dependent protein binding 1/633 76/18639 0.0131578947368421 0.387440758293839 0.928013423869319 0.999991843059779 GO:0140104 molecular carrier activity 5/633 249/18639 0.0200803212851406 0.591275052817907 0.92843803108645 0.999991843059779 GO:0019783 ubiquitin-like protein peptidase activity 2/633 127/18639 0.015748031496063 0.463708624099713 0.932734449590044 0.999991843059779 GO:0140030 modification-dependent protein binding 3/633 173/18639 0.0173410404624277 0.510615565843903 0.936272470348491 0.999991843059779 GO:0016798 hydrolase activity, acting on glycosyl bonds 2/633 130/18639 0.0153846153846154 0.453007655851258 0.938222259190891 0.999991843059779 GO:0015101 organic cation transmembrane transporter activity 1/633 81/18639 0.0123456790123457 0.363524662102861 0.939479308527861 0.999991843059779 GO:0004527 exonuclease activity 1/633 84/18639 0.0119047619047619 0.35054163845633 0.945463735947759 0.999991843059779 GO:0004860 protein kinase inhibitor activity 1/633 84/18639 0.0119047619047619 0.35054163845633 0.945463735947759 0.999991843059779 GO:0005525 GTP binding 8/633 378/18639 0.0211640211640212 0.623185135033476 0.945972447333593 0.999991843059779 GO:0005261 monoatomic cation channel activity 7/633 341/18639 0.0205278592375367 0.604453030534669 0.946830487499676 0.999991843059779 GO:0050660 flavin adenine dinucleotide binding 1/633 86/18639 0.0116279069767442 0.342389507329439 0.949121349264071 0.999991843059779 GO:0140101 catalytic activity, acting on a tRNA 2/633 139/18639 0.0143884892086331 0.42367622489686 0.952247729880869 0.999991843059779 GO:0004197 cysteine-type endopeptidase activity 1/633 88/18639 0.0113636363636364 0.334607927617406 0.952534016906191 0.999991843059779 GO:0003727 single-stranded RNA binding 1/633 89/18639 0.0112359550561798 0.330848287981256 0.954153658289318 0.999991843059779 GO:0008234 cysteine-type peptidase activity 3/633 187/18639 0.0160427807486631 0.472387662518691 0.955308726303023 0.999991843059779 GO:0008276 protein methyltransferase activity 1/633 95/18639 0.0105263157894737 0.309952606635071 0.962776212875351 0.999991843059779 GO:0030246 carbohydrate binding 5/633 280/18639 0.0178571428571429 0.525812457684496 0.963330504203613 0.999991843059779 GO:0019001 guanyl nucleotide binding 8/633 400/18639 0.02 0.588909952606635 0.964184752541562 0.999991843059779 GO:0032561 guanyl ribonucleotide binding 8/633 400/18639 0.02 0.588909952606635 0.964184752541562 0.999991843059779 GO:0008170 N-methyltransferase activity 1/633 98/18639 0.0102040816326531 0.300464261533997 0.9664596709932 0.999991843059779 GO:0015171 amino acid transmembrane transporter activity 1/633 102/18639 0.00980392156862745 0.288681349316978 0.970811076571421 0.999991843059779 GO:0008168 methyltransferase activity 3/633 204/18639 0.0147058823529412 0.433022023975467 0.971277777677219 0.999991843059779 GO:0004843 cysteine-type deubiquitinase activity 1/633 108/18639 0.00925925925925926 0.272643496577146 0.976304309677724 0.999991843059779 GO:0004222 metalloendopeptidase activity 1/633 110/18639 0.00909090909090909 0.267686342093925 0.977895543964148 0.999991843059779 GO:0016741 transferase activity, transferring one-carbon groups 3/633 215/18639 0.013953488372093 0.410867408795327 0.978549568051706 0.999991843059779 GO:0140098 catalytic activity, acting on RNA 7/633 387/18639 0.0180878552971576 0.532605900290238 0.978869210093743 0.999991843059779 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/633 167/18639 0.0119760479041916 0.352640690183614 0.978955783639535 0.999991843059779 GO:0017124 SH3 domain binding 1/633 115/18639 0.00869565217391304 0.256047805481146 0.98142231952856 0.999991843059779 GO:0035401 histone H3Y41 kinase activity 1/633 115/18639 0.00869565217391304 0.256047805481146 0.98142231952856 0.999991843059779 GO:0101005 deubiquitinase activity 1/633 115/18639 0.00869565217391304 0.256047805481146 0.98142231952856 0.999991843059779 GO:0140801 histone H2AXY142 kinase activity 1/633 115/18639 0.00869565217391304 0.256047805481146 0.98142231952856 0.999991843059779 GO:0003823 antigen binding 2/633 174/18639 0.0114942528735632 0.33845399575094 0.982917137414114 0.999991843059779 GO:0005096 GTPase activator activity 4/633 271/18639 0.014760147601476 0.434619891222609 0.98354472469666 0.999991843059779 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/633 122/18639 0.00819672131147541 0.241356537953539 0.985436258261257 0.999991843059779 GO:0008237 metallopeptidase activity 2/633 184/18639 0.0108695652173913 0.320059756851432 0.987346554288631 0.999991843059779 GO:0042826 histone deacetylase binding 1/633 127/18639 0.0078740157480315 0.231854312049856 0.987761312682989 0.999991843059779 GO:0015276 ligand-gated monoatomic ion channel activity 2/633 186/18639 0.010752688172043 0.316618254089589 0.988087305632911 0.999991843059779 GO:0022834 ligand-gated channel activity 2/633 188/18639 0.0106382978723404 0.313249974790763 0.988785753605232 0.999991843059779 GO:0140597 protein carrier chaperone 2/633 188/18639 0.0106382978723404 0.313249974790763 0.988785753605232 0.999991843059779 GO:0016887 ATP hydrolysis activity 7/633 417/18639 0.0167865707434053 0.494288929046336 0.988869664594327 0.999991843059779 GO:0005262 calcium channel activity 1/633 131/18639 0.00763358778625954 0.224774791071235 0.989351476685339 0.999991843059779 GO:0015297 antiporter activity 1/633 135/18639 0.00740740740740741 0.218114797261717 0.990735315418099 0.999991843059779 GO:0042393 histone binding 3/633 247/18639 0.0121457489878543 0.357637623040467 0.991029356484128 0.999991843059779 GO:0099094 ligand-gated monoatomic cation channel activity 1/633 136/18639 0.00735294117647059 0.216511011987734 0.991052249342674 0.999991843059779 GO:0140767 enzyme-substrate adaptor activity 1/633 139/18639 0.00719424460431655 0.21183811244843 0.991939562963595 0.999991843059779 GO:0004713 protein tyrosine kinase activity 1/633 140/18639 0.00714285714285714 0.210324983073798 0.99221536062003 0.999991843059779 GO:0015085 calcium ion transmembrane transporter activity 1/633 147/18639 0.00680272108843537 0.200309507689332 0.993899371658486 0.999991843059779 GO:0003730 mRNA 3'-UTR binding 3/633 262/18639 0.0114503816793893 0.337162186606852 0.994098511174969 0.999991843059779 GO:0004175 endopeptidase activity 6/633 405/18639 0.0148148148148148 0.436229594523433 0.994488098474803 0.999991843059779 GO:0046873 metal ion transmembrane transporter activity 7/633 450/18639 0.0155555555555556 0.458041074249605 0.994669296343033 0.999991843059779 GO:0022836 gated channel activity 4/633 318/18639 0.0125786163522013 0.370383617991594 0.995099955903935 0.999991843059779 GO:0004674 protein serine/threonine kinase activity 6/633 433/18639 0.0138568129330254 0.40802075238335 0.997190886484528 0.999991843059779 GO:0005244 voltage-gated monoatomic ion channel activity 1/633 173/18639 0.00578034682080925 0.170205188614634 0.99753504871646 0.999991843059779 GO:0022832 voltage-gated channel activity 1/633 175/18639 0.00571428571428571 0.168259986459039 0.997701149852793 0.999991843059779 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 2/633 243/18639 0.00823045267489712 0.242349774735241 0.99793779861969 0.999991843059779 GO:0004676 3-phosphoinositide-dependent protein kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0004711 ribosomal protein S6 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0035175 histone H3S10 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0035979 histone H2AXS139 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0044022 histone H3S28 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0044023 histone H4S1 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0044024 histone H2AS1 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0044025 histone H2BS14 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0072354 histone H3T3 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0072371 histone H2AS121 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0072518 Rho-dependent protein serine/threonine kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0140823 histone H2BS36 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0140855 histone H3S57 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0140995 histone H2A kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0140997 histone H4 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0140998 histone H2B kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:1990244 histone H2AT120 kinase activity 2/633 245/18639 0.00816326530612245 0.240371409227198 0.998062897731431 0.999991843059779 GO:0004677 DNA-dependent protein kinase activity 2/633 246/18639 0.00813008130081301 0.239394289677494 0.998122615200611 0.999991843059779 GO:0140857 histone H3T45 kinase activity 2/633 246/18639 0.00813008130081301 0.239394289677494 0.998122615200611 0.999991843059779 GO:0035402 histone H3T11 kinase activity 2/633 247/18639 0.00809716599190283 0.238425082026978 0.998180519353398 0.999991843059779 GO:0035403 histone H3T6 kinase activity 2/633 247/18639 0.00809716599190283 0.238425082026978 0.998180519353398 0.999991843059779 GO:0004679 AMP-activated protein kinase activity 2/633 248/18639 0.00806451612903226 0.237463690567192 0.998236664214774 0.999991843059779 GO:0141003 histone H2AX kinase activity 3/633 354/18639 0.00847457627118644 0.249538115511286 0.999593632980297 0.999991843059779 GO:0140996 histone H3 kinase activity 3/633 357/18639 0.00840336134453781 0.24744115655741 0.999628536164711 0.999991843059779 GO:0035173 histone kinase activity 3/633 360/18639 0.00833333333333333 0.245379146919431 0.999660488000383 0.999991843059779 GO:0106310 protein serine kinase activity 3/633 361/18639 0.00831024930747922 0.244699426290846 0.999670525677742 0.999991843059779 GO:0045182 translation regulator activity 2/633 356/18639 0.00561797752808989 0.165424143990628 0.999944475299303 0.999991843059779 GO:0030371 translation repressor activity 1/633 329/18639 0.00303951367781155 0.089499992797361 0.999989564732243 0.999991843059779 GO:0140097 catalytic activity, acting on DNA 1/633 336/18639 0.00297619047619048 0.0876354096140826 0.999991843059779 0.999991843059779