category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	74/1638	181/9376	2.34022085955788	CD74/TLR2/HLA-DMA/ATP6AP1/HLA-DQA1/STAT1/C3/HLA-DMB/SYK/HLA-DPA1/IL10RA/RIPK2/ATP6V0B/CLEC7A/IL18/CIITA/RAB5C/CYCS/FCGR2A/JAK2/CREB1/TLR1/CTSD/NFKB1/ITGB2/IL10RB/CORO1A/HLA-DRA/PLK3/HLA-DRB1/TLR4/ATP6V0A1/CAMP/MRC2/ATP6V0C/IRAK2/FCGR3A/HLA-DQA2/IL1B/HLA-DPB1/CALM2/NFYC/HLA-DOA/IFNGR2/TNF/TRAF6/HLA-DQB1/RELA/CALM3/FCER1G/TGFB1/CEBPG/TGFB2/CTSS/MRC1/IL1A/IL10/CASP10/RHOA/FCGR2B/CAMK2D/SPHK1/CAMK2G/PPP3CA/PPP3R1/HSPD1/CALML4/CR1L/CEBPB/RFX5/TLR6/IL23A/CASP9/IL6	8.37660463909428
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	41/1638	78/9376	3.00879747033593	TLR2/HLA-DMA/HLA-DQA1/STAT1/C3/HLA-DMB/HLA-DPA1/NCF4/FCGR2A/JAK2/NFKB1/ITGB2/NCF1/HLA-DRA/ITGA4/HLA-DRB1/TLR4/NFKBIB/TAB2/FCGR3A/HLA-DQA2/IL1B/HLA-DPB1/MAP3K7/HLA-DOA/IFNGR2/PTPN6/TNF/TRAF6/HLA-DQB1/RELA/TGFB1/TGFB2/PTGS2/IL1A/IL10/NFKBIA/CYBA/FOS/CR1L/JUN	8.1962822866391
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	89/1638	250/9376	2.03776312576313	CTSH/NPC2/DMXL2/CD68/ATP6AP1/GPR155/GLA/MANBA/BORCS7/TPP1/AGA/NEU1/VAMP8/ATP6V1B2/MAN2B1/CTSA/OSBPL3/M6PR/CTSZ/ATP6V0B/ACP5/ATP6V1E1/GGA1/IDS/VPS29/GAA/PPT1/AP1S2/TLR7/CTSD/DEPTOR/ASAH1/ARSB/HEXA/AP1B1/ARL8A/ACP2/ATP6V0A1/AP5Z1/ATP6V0C/WDR7/GM2A/AP2A2/CLN5/BLOC1S1/SUMF1/ATP6V1F/GNPTG/SLC29A1/MCOLN1/CLTB/OSBPL1A/MITF/ARL8B/CLCN7/NPC1/CTSK/SLC36A4/SLC17A5/AP3S2/NAGA/LAMTOR5/ZFYVE26/BORCS8/VAMP7/ROGDI/CTSS/LAMTOR4/AP2S1/LAPTM5/SMPD1/AP1S1/CTSL/VPS18/LGMN/MLST8/PSAP/SLC38A9/VPS33A/CTSC/AP4E1/TELO2/FIG4/NAGPA/TLR3/CLN8/CTSV/CTSB/CTNS	7.65166999752322
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	82/1638	224/9376	2.09541252398395	TGFBR1/HLA-DMA/ETS2/EGR2/HLA-DQA1/ZFP36/HLA-DMB/HLA-DPA1/HLA-F/SPI1/IL1R2/SLC25A5/ANAPC10/ICAM1/B2M/CREB1/NFATC2/NFKB1/ITGB2/CREB5/IKBKB/HLA-DRA/CDC27/HLA-DRB1/BUB3/CDKN2C/RANBP1/RB1/HRAS/HLA-DQA2/HLA-DPB1/MAP2K1/MAP3K3/NFKB2/PTTG1/CCND3/RELB/CD4/NRAS/MAP2K4/HLA-DOA/MAP3K1/NFATC1/TNF/TLN2/HLA-DQB1/RELA/CDKN2A/PIK3CD/BCL2L1/PIK3CB/TGFB1/CREB3/ANAPC4/ATF6B/TGFB2/HLA-A/MAD1L1/MAD2L1/E2F3/CCNA2/CCNB2/NFKBIA/BUB1B/TSPO/CHUK/CDC23/PPP3CA/PPP3R1/HLA-E/ESPL1/CREB3L1/FOS/POLB/HLA-B/CDC20/CRTC2/KAT2A/SRF/JUN/IL6/HLA-C	7.63434759419431
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	77/1638	216/9376	2.04051915163026	APOA1/MMP9/LY96/CCL2/TLR2/HSPA1B/HSPA1A/IRF7/NCF4/IL18/ATF6/OLR1/CYCS/CCL3/ICAM1/JAK2/POU2F2/PYCARD/NFATC2/NFKB1/NCF1/IKBKB/HSP90AA1/TLR4/TICAM1/TAB2/LYN/CXCL3/DDIT3/HRAS/IL1B/ABCG1/CASP1/CALM2/TNFSF10/VAV1/MAP2K3/CCL5/TRAF3/NRAS/MAP2K4/MAP3K7/NFATC1/CXCL2/TNF/TRAF6/RELA/PIK3CD/CALM3/BCL2L1/NLRP3/TNFRSF10B/PIK3CB/HSPA6/TICAM2/TANK/MIB1/NFKBIA/XBP1/MAP2K6/CYBA/RHOA/CHUK/CAMK2D/CAMK2G/PPP3CA/PPP3R1/FOS/HSPD1/CALML4/MAP3K5/PLCB2/NFE2L2/JUN/TLR6/CASP9/IL6	7.11799110804131
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	57/1638	142/9376	2.29768353712016	TREM2/TGFBR1/FOSB/STAT1/IRF9/SYK/NCF4/ACP5/SPI1/FCGR2A/CREB1/NFATC2/NFKB1/NCF1/LILRB4/IKBKB/BLNK/TYROBP/SIRPA/TAB2/LCP2/FCGR3A/IL1B/MAP2K1/NFKB2/JUND/MITF/RELB/GRB2/CYLD/MAP3K7/IFNGR2/CTSK/NFATC1/TNF/TRAF6/RELA/PIK3CD/PIK3CB/TGFB1/TGFB2/LILRB1/IL1A/NFKBIA/MAP2K6/CYBA/FCGR2B/LILRA2/TEC1/CHUK/PPP3CA/PPP3R1/JUNB/FOS/SQSTM1/JUN/ITPR2	7.1687965672705
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	61/1638	157/9376	2.22399539596992	IGFBP3/TGFBR1/HLA-F/SLC25A5/CDK1/NFATC2/NFKB1/MRAS/NBN/RB1/EIF4EBP1/CDK6/SERPINE1/HRAS/MAP2K1/CALM2/MAP2K3/CCND3/RHEB/NRAS/FBXW11/BTRC/NFATC1/CCNB1/RELA/CDKN2A/PIK3CD/GADD45G/CALM3/PIK3CB/TGFB1/MRE11/RASSF5/E2F4/TGFB2/HLA-A/GADD45B/IL1A/FOXM1/RBL1/LIN54/ZFP36L2/FOXO3/E2F3/CCNA2/CCNB2/MAP2K6/RAD1/PPP3CA/PPP3R1/ZFP36L1/HLA-E/HLA-B/MYBL2/CALML4/LIN9/RAD9A/SQSTM1/IL6/ITPR2/HLA-C	7.11567210289692
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	64/1638	173/9376	2.11756900774242	MX1/CCL2/HLA-DMA/IFIH1/HLA-DQA1/STAT1/MX2/IRF9/HLA-DMB/IRF7/HLA-DPA1/EIF2AK2/IL18/SLC25A5/CIITA/OAS2/OAS1/CYCS/ICAM1/JAK2/RSAD2/TLR7/RAB11B/PYCARD/NFKB1/PML/IKBKB/HLA-DRA/OAS3/HLA-DRB1/TLR4/NFKBIB/TICAM1/CDK6/NXT1/HLA-DQA2/IL1B/HLA-DPB1/MAP2K1/CASP1/TNFSF10/CCND3/CCL5/TRAF3/HLA-DOA/IFNGR2/TNF/DNAJB1/HLA-DQB1/PABPN1/RELA/PIK3CD/NLRP3/TNFRSF10B/PIK3CB/KPNA2/NUP98/IL1A/NFKBIA/CXCL10/CHUK/TLR3/CASP9/IL6	6.82591560272688
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	42/1638	95/9376	2.5306342780027	CCL2/TLR2/TNFSF13B/HLA-DMA/ATP6AP1/HLA-DQA1/ATP6V1B2/HLA-DMB/HLA-DPA1/CD86/ATP6V0B/ACP5/IL18/ATP6V1E1/CCL3/ICAM1/ITGB2/HLA-DRA/HLA-DRB1/TLR4/ATP6V0A1/ATP6V0C/CXCL3/TNFSF13/HLA-DQA2/IL1B/HLA-DPB1/ATP6V1F/CCL5/HLA-DOA/CTSK/CXCL2/TNF/HLA-DQB1/TGFB1/TGFB2/IL1A/CTSL/FOS/JUN/IL23A/IL6	6.89864942392882
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	65/1638	180/9376	2.06701940035273	CD74/CCL2/TLR2/BST2/HLA-DMA/IFIH1/HLA-DQA1/STAT1/C3/IRF9/HLA-DMB/IRF7/SYK/HLA-DPA1/EIF2AK2/HLA-F/OAS2/OAS1/CYCS/B2M/JAK2/POU2F2/NFKB1/PML/IKBKB/HLA-DRA/OAS3/HLA-DRB1/SP100/NECTIN2/TICAM1/TAB2/BIRC2/EIF4EBP1/HLA-DQA2/IL1B/HLA-DPB1/CCL5/RHEB/TNFRSF14/TRAF3/MAP3K7/HLA-DOA/IFNGR2/TNF/TRAF6/HLA-DQB1/RELA/PIK3CD/TAPBPL/BCL2L1/PIK3CB/PILRB/HLA-A/NFKBIA/CHUK/EIF2B5/HLA-E/SRSF7/HLA-B/C5/TLR3/CASP9/IL6/HLA-C	6.65023988402083
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	59/1638	158/9376	2.13746309948842	CCNH/ANAPC10/CDK1/CDC27/PPP2R5C/YWHAH/BUB3/CDKN2C/RB1/CDK6/CDC25B/RBX1/SMC1A/CDKN1C/AURKB/PTTG1/CCND3/BUB1/CCNB1/KNL1/CDKN2A/GADD45G/CDCA5/DBF4/TGFB1/NDC80/ANAPC4/E2F4/TGFB2/STAG2/MAD1L1/GADD45B/RBL1/MAD2L1/E2F3/ORC6/CCNA2/CDC25C/PLK1/WEE1/CCNB2/PCNA/MCM7/TTK/BUB1B/YWHAQ/MCM6/FZR1/FBXO5/CDC23/MCM5/SGO1/ESPL1/ESCO2/CDC20/PKMYT1/MTBP/CDT1/TICRR	6.63400405105716
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	46/1638	112/9376	2.35095063666492	LY96/TLR2/HLA-DMA/HSPA1B/HLA-DQA1/STAT1/HSPA1A/HLA-DMB/ALOX5/HLA-DPA1/IL10RA/CIITA/CYCS/JAK2/NFKB1/IL10RB/IKBKB/HLA-DRA/HLA-DRB1/TLR4/NFKBIB/ITGA6/TAB2/BIRC2/HLA-DQA2/HLA-DPB1/MAP2K3/PIK3CG/MAP3K7/HLA-DOA/PIK3R5/IFNGR2/TNF/TRAF6/HLA-DQB1/RELA/BCL2L1/TGFB1/HSPA6/TGFB2/LAMC3/IL10/NFKBIA/MAP2K6/CHUK/CASP9	6.61724847731234
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	58/1638	163/9376	2.03677985273077	MMP9/TLR2/TGFBR1/ATP6AP1/IFIH1/EGR2/STAT1/IRF7/CYCS/JAK2/CREB1/NFATC2/NFKB1/CREB5/IKBKB/TLR4/TICAM1/RB1/TAB2/HRAS/MAP2K1/MAP2K3/GRB2/TRAF3/NRAS/MAP2K4/DDB2/MAP3K7/EGR3/MAP3K1/NFATC1/TNF/TRAF6/RELA/PIK3CD/PIK3CB/TGFB1/CREB3/BIRC5/ATF6B/TGFB2/TICAM2/BRAF/E2F3/CCNA2/PCNA/NFKBIA/CASP10/YWHAQ/MAP2K6/CHUK/CREB3L1/FOS/TLR3/JUN/DDX3X/CASP9/IL6	6.14338934292635
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	68/1638	205/9376	1.89871050358855	ISG15/TLR2/HLA-DMA/CD58/HLA-DQA1/STAT1/SAP30/NFKBIE/IRF9/HLA-DMB/IRF7/SYK/HLA-DPA1/EIF2AK2/HLA-F/OAS2/OAS1/CYCS/ICAM1/B2M/NFKB1/IKBKB/HLA-DRA/ADRM1/OAS3/BLNK/HLA-DRB1/NFKBIB/RB1/TAB2/LYN/CDK6/HLA-DQA2/HLA-DPB1/NFKB2/TNFAIP3/MAP2K3/CCND3/RELB/TRAF3/MAP2K4/DDB2/MAP3K7/HLA-DOA/TNF/TRAF6/HLA-DQB1/RELA/PIK3CD/GADD45G/PSMD6/TAPBPL/PIK3CB/HLA-A/GADD45B/E2F3/CCNA2/NFKBIA/CXCL10/MAP2K6/ENTPD3/CHUK/HLA-E/HLA-B/JUN/CASP9/IL6/HLA-C	5.98572314195847
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	51/1638	138/9376	2.11541115888942	CCL2/FYB1/SKAP2/RHOG/IL18/FCGR2A/PYCARD/NFATC2/NFKB1/IKBKB/WIPF1/ITGA4/WAS/TLR4/ELMO1/GIT2/TICAM1/TAB2/LCP2/PKN2/IL1B/ARPC1B/MAP2K1/CASP1/VAV1/MAP2K3/CD4/RAC2/RPS6KA3/MAP2K4/MAP3K7/NFATC1/TNF/TRAF6/RELA/PIK3CD/ARHGEF7/NLRP3/PIK3CB/RPS6KA1/GNAQ/IL10/ARPC3/NFKBIA/MAP2K6/RHOA/CHUK/FOS/BAIAP2/JUN/IL6	6.07314672223551
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	42/1638	105/9376	2.28962148962149	EGR2/PAK1/STAT1/IRF9/SYK/CLEC7A/PYCARD/NFATC2/NFKB1/IKBKB/MRAS/PLK3/HRAS/BCL3/IL1B/CASP1/NFKB2/CALM2/RELB/CYLD/NRAS/EGR3/NFATC1/TNF/RELA/PIK3CD/CALM3/FCER1G/NLRP3/PIK3CB/PTGS2/IL10/NFKBIA/RHOA/CHUK/PPP3CA/PPP3R1/CALML4/JUN/IL23A/IL6/ITPR2	6.11394946324202
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	55/1638	155/9376	2.03111583756745	TLR2/HLA-DMA/ATP6AP1/MSR1/HLA-DQA1/C3/ATP6V1B2/STX7/HLA-DMB/HLA-DPA1/M6PR/NCF4/HLA-F/ATP6V0B/CLEC7A/ATP6V1E1/RAB5C/OLR1/FCGR2A/ITGB2/NCF1/CORO1A/HLA-DRA/HLA-DRB1/TLR4/ATP6V0A1/MRC2/ATP6V0C/FCGR3A/HLA-DQA2/COLEC11/HLA-DPB1/ATP6V1F/TUBB2A/HLA-DOA/TUBA1C/HLA-DQB1/STX18/SEC61G/CTSS/HLA-A/MRC1/TUBA1B/CTSL/CYBA/FCGR2B/TUBA3E/RILP/TUBB4B/HLA-E/HLA-B/TUBB/THBS1/TLR6/HLA-C	5.95542171038077
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	34/1638	82/9376	2.37338812948569	CD74/HLA-DMA/HSPA1B/HLA-DQA1/HSPA1A/HLA-DMB/HLA-DPA1/HLA-F/CIITA/B2M/CREB1/HSP90AA1/HLA-DRA/HLA-DRB1/IFI30/HLA-DQA2/HLA-DPB1/NFYC/CD4/HLA-DOA/TNF/HLA-DQB1/TAPBPL/KLRC3/HSPA6/CTSS/HLA-A/CTSL/LGMN/HLA-E/HLA-B/CTSB/RFX5/HLA-C	5.74681353177084
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	61/1638	187/9376	1.8672046907341	CCL2/STAT1/NLRP1/IRF9/IRF7/RIPK2/IL18/OAS2/OAS1/PYCARD/NFKB1/ATG5/GBP4/IKBKB/HSP90AA1/NAMPT/OAS3/TLR4/NFKBIB/TICAM1/CAMP/TAB2/BIRC2/CXCL3/GSDMD/TRPM2/PKN2/P2RX7/IL1B/GPSM3/CASP1/CARD8/TNFAIP3/CCL5/GBP2/GBP1/TRAF3/MAP3K7/CASP4/CXCL2/TNF/TRAF6/RELA/BCL2L1/NLRP3/TANK/NFKBIA/CYBA/RHOA/CHUK/DHX33/RNF31/GABARAP/PLCB2/TRPV2/CTSB/ERBIN/AIM2/JUN/IL6/ITPR2	5.51107752111934
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	41/1638	109/9376	2.15308442831379	LY96/TLR2/STAT1/IRF9/IRF7/CD86/CCL3/TLR1/TLR7/NFKB1/IKBKB/TLR4/TICAM1/TLR5/TAB2/MAP3K8/IL1B/MAP2K1/MAP2K3/CCL5/CCL4/TRAF3/MAP2K4/MAP3K7/CTSK/TNF/TRAF6/RELA/PIK3CD/PIK3CB/TICAM2/IRF5/NFKBIA/CXCL10/MAP2K6/CHUK/FOS/TLR3/JUN/TLR6/IL6	5.57099795426113
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	39/1638	103/9376	2.16736014794267	CCL2/TLR2/TGFBR1/C3/CCL3/NFKB1/IKBKB/C1QB/TLR4/GNA15/TICAM1/SERPINE1/IL1B/PPP2R2D/PPP2R2A/CCL5/MAP2K4/IFNGR2/TNF/C1QA/TRAF6/RELA/PIK3CD/PIK3CB/TGFB1/C1QC/TGFB2/GNAQ/IL10/NFKBIA/CHUK/FOS/GNAS/PLCB2/PPP2R2B/GNAL/JUN/TLR6/IL6	5.4807699036952
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	43/1638	119/9376	2.06835554734714	MMP9/CCL2/ICAM1/CREB1/NFKB1/CREB5/IKBKB/TAB2/BIRC2/ADAM17/CXCL3/MAP3K8/BCL3/IL1B/MAP2K1/TNFAIP3/RHBDF2/MAP2K3/CCL5/CYLD/TRAF3/MAP2K4/MAP3K7/CXCL2/TNF/RELA/PIK3CD/PIK3CB/CREB3/ATF6B/PTGS2/NFKBIA/CASP10/CXCL10/MAP2K6/CHUK/JUNB/CREB3L1/FOS/MAP3K5/CEBPB/JUN/IL6	5.39612973386018
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	28/1638	66/9376	2.42838642838643	TLR2/HLA-DMA/HLA-DQA1/STAT1/HLA-DMB/HLA-DPA1/IL18/NFKB1/HLA-DRA/HLA-DRB1/TLR4/TLR5/HLA-DQA2/IL1B/HLA-DPB1/HLA-DOA/IFNGR2/NFATC1/TNF/HLA-DQB1/RELA/TGFB1/TGFB2/IL1A/IL10/JUN/IL23A/IL6	5.35760963127458
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	73/1638	248/9376	1.68490291070936	LY96/TLR2/PAK1/RIPK2/M6PR/RHOG/IL18/RAB5C/CYCS/PYCARD/NFKB1/IKBKB/HSP90AA1/SNX18/DYNLRB1/TLR4/ARL8A/CSE1L/ELMO1/NCKAP1L/DYNLT3/TLR5/TAB2/BIRC2/PTPRC/GSDMD/HRAS/DYNLT1/IL1B/ARPC1B/CYTH1/MAP2K1/CASP1/TNFSF10/TUBB2A/MAP2K3/PIK3CG/ARL8B/ABI1/MAP2K4/MAP3K7/CASP4/TUBA1C/TNF/RHOB/TRAF6/RELA/PIK3CD/NLRP3/TNFRSF10B/PIK3CB/CYTH3/TUBA1B/VPS18/EXOC2/ARPC3/NFKBIA/MAP2K6/RHOA/TUBA3E/CHUK/VPS33A/RILP/TUBB4B/PODXL/FOS/TUBB/FBXO22/PFN1/MYL12A/JUN/TLR6/IL6	5.02915777810238
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	25/1638	56/9376	2.5553811268097	TLR2/HSPA1B/C3/HSPA1A/IL18/CYCS/PYCARD/NFKB1/ITGB2/TLR4/TLR5/CXCL3/IL1B/CASP1/NFKB2/CXCL2/TNF/RELA/HSPA6/NFKBIA/RAB1A/HSPD1/CR1L/CASP9/IL6	5.37094996306529
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	31/1638	78/9376	2.27494442879058	LY96/C3/SERPING1/PYCARD/NFKB1/ITGB2/C1QB/TLR4/TICAM1/IRF8/IL1B/CASP1/CALM2/TNF/C1QA/CFL2/TRAF6/RELA/CALM3/NLRP3/C1QC/TICAM2/IL1A/IL10/RHOA/FOS/CALML4/C5/JUN/IL23A/IL6	5.20201991114511
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	21/1638	44/9376	2.73193473193473	HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DPA1/CD86/HLA-F/HLA-DRA/HLA-DRB1/HLA-DQA2/IL1B/HLA-DPB1/HLA-DOA/TNF/HLA-DQB1/HLA-A/IL1A/ICA1/HLA-E/HLA-B/HSPD1/HLA-C	5.29783854762624
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	60/1638	196/9376	1.75226134409808	ATG3/STAT1/ZFP36/C3/IRF9/IRF7/SYK/CD86/EIF2AK2/HLA-F/PREX1/CYCS/ICAM1/JAK2/CREB1/NFATC2/NFKB1/IKBKB/HCK/TICAM1/RB1/LYN/CXCL3/CDK6/HRAS/MAP2K1/CALM2/PIK3CG/PDGFB/TRAF3/NRAS/MAP2K4/PIK3R5/NFATC1/CXCL2/RELA/PIK3CD/CALM3/PIK3CB/GNG7/HLA-A/GNG5/PTGS2/E2F3/NFKBIA/MAP2K6/CHUK/PPP3CA/PPP3R1/HLA-E/FOS/HLA-B/CALML4/TLR3/HIF1A/JUN/CASP9/IL6/ITPR2/HLA-C	4.89670188814279
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	34/1638	91/9376	2.13865743536073	NFKBIE/SYK/CD22/NFATC2/NFKB1/LILRB4/INPP5D/IKBKB/BLNK/NFKBIB/PIK3AP1/LYN/HRAS/DAPP1/MAP2K1/VAV1/RAC2/GRB2/NRAS/PTPN6/NFATC1/RELA/PIK3CD/PIK3CB/LILRB1/NFKBIA/FCGR2B/LILRA2/CHUK/PPP3CA/PPP3R1/FOS/CD79B/JUN	5.02170333778758
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	60/1638	200/9376	1.71721611721612	PAK1/NCK1/GNA13/IL18/MYO5A/CYCS/FCGR2A/HCLS1/PYCARD/NFKB1/IKBKB/WIPF1/MYO1F/TLR4/NFKBIB/NCKAP1L/TLR5/SEC24B/TAB2/IL1B/ARPC1B/ARHGEF11/CYTH1/CASP1/NCK2/TNFSF10/TUBB2A/CLDN4/ABI1/CLDN20/MAP3K7/CASP4/TUBA1C/PTPN6/TNF/TRAF6/RELA/NLRP3/MYH10/TNFRSF10B/TMED10/CYTH3/TUBA1B/ARPC3/TMBIM6/NFKBIA/RHOA/RAB1A/TUBA3E/LPAR5/CHUK/TUBB4B/CLDN10/FOS/CLDN1/TUBB/BAIAP2/JUN/CASP9/IL6	4.71700742680124
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	18/1638	36/9376	2.86202686202686	RNASEH2C/POLE4/RNASEH2B/RPA3/POLE3/PRIM2/PRIM1/POLD3/POLA1/RFC3/PCNA/MCM7/MCM6/MCM5/LIG1/POLE/RFC5/POLE2	5.14981915641897
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	45/1638	137/9376	1.88016363198845	CTSH/PMAIP1/CTSZ/CYCS/CTSD/NFKB1/IKBKB/PARP4/BIRC2/DDIT3/HRAS/MAP2K1/TNFSF10/NRAS/NOL3/CTSK/TUBA1C/TNF/RELA/PIK3CD/GADD45G/BCL2L1/TNFRSF10B/PIK3CB/BIRC5/CTSS/GADD45B/TUBA1B/CTSL/LMNB1/NFKBIA/CASP10/TUBA3E/CHUK/CTSC/FOS/CSF2RB/MAP3K5/CTSV/CTSB/IL3RA/LMNA/JUN/CASP9/ITPR2	4.77462693803394
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	16/1638	30/9376	3.05282865282865	NFKB1/IKBKB/FOLR2/ABCC3/TYMS/ABCC1/IL1B/DHFR/GGH/TNF/RELA/SHMT2/SHMT1/CHUK/SLC46A1/IL6	5.18117980491053
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	38/1638	109/9376	1.99554166526644	AHR/TGFBR1/HLA-DMA/HLA-DQA1/STAT1/NFKBIE/HLA-DMB/HLA-DPA1/JAK2/NFATC2/NFKB1/IKBKB/HSP90AA1/HLA-DRA/HLA-DRB1/NFKBIB/IL1RAP/RUNX1/HLA-DQA2/IL1B/HLA-DPB1/CD4/HLA-DOA/IFNGR2/NFATC1/HLA-DQB1/RELA/EBI3/TGFB1/NFKBIA/CHUK/PPP3CA/PPP3R1/FOS/HIF1A/JUN/IL23A/IL6	4.80984778251794
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	33/1638	90/9376	2.0988196988197	TLR2/STAT1/NFKBIE/JAK2/CSNK2B/NFATC2/NFKB1/IKBKB/TLR4/NFKBIB/TICAM1/HRAS/MAP2K1/MAP3K3/MAP2K3/CD4/NRAS/IFNGR2/PTPN6/NFATC1/TRAF6/RELA/PIK3CD/PIK3CB/TICAM2/NFKBIA/MAP2K6/CHUK/PPP3CA/PPP3R1/FOS/HIF1A/JUN	4.81905159184507
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	17/1638	34/9376	2.86202686202686	PER3/PER1/CREB1/NR1D2/FBXL3/BHLHE40/BHLHE41/CSNK1E/RBX1/NR1D1/PRKAG2/FBXW11/BTRC/CLOCK/DBP/PRKAG1/CRY2	5.00418887632399
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	60/1638	205/9376	1.67533279728402	EGR2/C3/PMAIP1/IRF9/GTF2A2/IRF7/SYK/EIF2AK2/HLA-F/CDK1/CREB1/RASA2/NFKB1/CREB5/SP100/YWHAH/RANBP1/RB1/LYN/CDK6/HRAS/HDAC9/MRPS18B/NFKB2/GTF2B/CCND3/GRB2/TRAF3/NRAS/SCIN/EGR3/GTF2H1/RELA/CDKN2A/PIK3CD/PIK3CB/CREB3/ATF6B/HLA-A/MAD1L1/RBL1/CCNA2/GTF2A1/NFKBIA/YWHAQ/RHOA/GTF2E1/HLA-E/CREB3L1/POLB/HLA-B/CDC20/REL/KAT2A/SCRIB/GTF2H4/SRF/JUN/DDX3X/HLA-C	4.49795027106655
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	62/1638	214/9376	1.65837070509968	TLR2/BST2/PAK1/HLA-F/CXCR4/CYCS/B2M/CDK1/AP1S2/NFATC2/NFKB1/IKBKB/AP1B1/TLR4/TAB2/LIMK2/HRAS/RBX1/MAP2K1/ELOC/CALM2/MAP2K3/CD4/RAC2/NRAS/FBXW11/BTRC/MAP3K7/SAMHD1/NFATC1/CCNB1/TNF/CFL2/TRAF6/RELA/PIK3CD/CALM3/TAPBPL/BCL2L1/PIK3CB/GNG7/HLA-A/GNG5/GNAQ/AP1S1/CDC25C/WEE1/CCNB2/NFKBIA/MAP2K6/CHUK/PPP3CA/PPP3R1/HLA-E/CUL4B/FOS/HLA-B/CALML4/JUN/CASP9/ITPR2/HLA-C	4.48239851331377
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	81/1638	300/9376	1.54549450549451	PDGFC/TGFBR1/NR4A1/MEF2C/PAK1/HSPA1B/HSPA1A/DUSP6/RASGRP2/PLA2G4C/ARRB2/DUSP1/RASA2/NFKB1/TAOK3/MAP4K3/RASA1/IKBKB/MRAS/STMN1/IL1RAP/PLA2G4A/TAB2/DDIT3/MAPKAPK3/CDC25B/MAP3K2/HRAS/MAP3K8/DUSP2/IL1B/MAP3K11/MAP2K1/MAP3K3/NFKB2/JUND/MAP2K3/RELB/PDGFB/NLK/RAC2/GRB2/NRAS/RPS6KA3/MAP2K4/MAP3K7/MAP3K1/RAPGEF2/NFATC1/TNF/TRAF6/RELA/GADD45G/CACNA2D3/TGFB1/RPS6KA1/HSPA6/TGFB2/GADD45B/BRAF/IL1A/PDGFD/ARRB1/DUSP5/MAPK7/MAP2K6/CHUK/FGFR1/PPP3CA/PPP3R1/FOS/KDR/HGF/IGF2/PTPN7/CACNB4/EFNA4/MAP3K5/RASGRF1/SRF/JUN	4.41806385467895
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	36/1638	105/9376	1.96253270538985	LY96/TNFSF13B/PLAU/SYK/EDA/ICAM1/CSNK2B/NFKB1/IKBKB/BLNK/TLR4/TICAM1/TAB2/BIRC2/LYN/CXCL3/IL1B/NFKB2/TNFAIP3/RELB/CCL4/CYLD/TRAF3/MAP3K7/CXCL2/TNF/TRAF6/RELA/GADD45G/BCL2L1/TICAM2/PTGS2/GADD45B/NFKBIA/CHUK/CCL21	4.56325857224851
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	20/1638	45/9376	2.54402387735721	HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DPA1/CD86/HLA-F/HLA-DRA/HLA-DRB1/HLA-DQA2/IL1B/HLA-DPB1/HLA-DOA/TNF/HLA-DQB1/HLA-A/IL1A/HLA-E/HLA-B/IL6/HLA-C	4.77666075881429
Human Diseases	Immune disease	hsa05330	Allograft rejection	18/1638	39/9376	2.64187094956326	HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DPA1/CD86/HLA-F/HLA-DRA/HLA-DRB1/HLA-DQA2/HLA-DPB1/HLA-DOA/TNF/HLA-DQB1/HLA-A/IL10/HLA-E/HLA-B/HLA-C	4.72711172634739
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	48/1638	157/9376	1.7500291640419	PTGER4/GPR132/SGK1/ATP11A/ALOX5/GAS6/MERTK/RAB5C/JAK2/CREB1/NFATC2/C1QB/ELMO1/SIRPA/ADAM17/UQCRFS1/DUSP2/MAP2K1/CASP1/PTPN6/NFATC1/GULP1/C1QA/ARG1/TGFB1/C1QC/XKR6/SIGLEC10/STAB1/PPARD/ATP8A1/PTGS2/IL10/VPS18/ARG2/DUSP5/PLA2G6/VPS33A/CAMK2D/SPHK1/CAMK2G/MFGE8/TGFBRAP1/P2RY6/THBS1/CEBPB/P2RY12/HIF1A	4.36027914525198
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	24/1638	63/9376	2.18059189487761	CCNH/POLR2K/POLR2J/POLE4/POLR2I/POLR2J3/RPA3/ERCC1/GTF2H5/POLR2F/POLE3/RBX1/DDB2/GTF2H1/POLD3/XPC/RFC3/PCNA/LIG1/POLE/CUL4B/RFC5/POLE2/GTF2H4	4.32567109782755
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/1638	75/9376	2.06065934065934	IGFBP3/PMAIP1/CYCS/SIVA1/CDK1/SESN1/CDK6/SERPINE1/CCND3/CD82/DDB2/MDM4/CCNB1/CDKN2A/COP1/GADD45G/RRM2B/BCL2L1/TNFRSF10B/RRM2/GTSE1/GADD45B/AIFM2/CCNB2/PERP/THBS1/CASP9	4.24296993701864
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	31/1638	93/9376	1.90801790801791	HLA-DMA/HLA-DQA1/STAT1/NFKBIE/HLA-DMB/HLA-DPA1/MAML3/JAK2/NFATC2/NFKB1/IKBKB/HLA-DRA/HLA-DRB1/NFKBIB/HLA-DQA2/HLA-DPB1/CD4/HLA-DOA/IFNGR2/NFATC1/HLA-DQB1/RELA/NOTCH1/NFKBIA/MAML1/CHUK/PPP3CA/PPP3R1/FOS/MAML2/JUN	4.0487404541932
Human Diseases	Infectious disease: viral	hsa05162	Measles	41/1638	136/9376	1.7256338432809	MX1/TLR2/IFIH1/HSPA1B/STAT1/MX2/HSPA1A/IRF9/IRF7/EIF2AK2/OAS2/OAS1/CYCS/CSNK2B/TLR7/NFKB1/IKBKB/OAS3/TLR4/NFKBIB/TAB2/CDK6/IL1B/TNFAIP3/CCND3/TRAF3/MAP3K7/TRAF6/RELA/PIK3CD/BCL2L1/PIK3CB/HSPA6/IL1A/NFKBIA/FCGR2B/CHUK/FOS/JUN/CASP9/IL6	3.9217438362295
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	61/1638	227/9376	1.53818183774131	CCL2/PTGER4/IL10RA/HLA-F/GNA13/CXCR4/CYCS/CCL3/B2M/CREB1/NFATC2/NFKB1/IL10RB/CREB5/IKBKB/RB1/EIF4EBP1/CDK6/HRAS/IL1B/ARHGEF11/MAP2K1/CALM2/CCL5/RHEB/CCL4/RAC2/GRB2/NRAS/NFATC1/TNF/RELA/CDKN2A/PIK3CD/CALM3/TAPBPL/PIK3CB/GNG7/CREB3/ATF6B/HLA-A/GNG5/PTGS2/GNAQ/E2F3/NFKBIA/MAP2K6/RHOA/CHUK/PPP3CA/PPP3R1/HLA-E/CREB3L1/HLA-B/GNAS/CALML4/PLCB2/CASP9/IL6/ITPR2/HLA-C	3.77644684638712
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	42/1638	142/9376	1.69302997472012	MMP9/KLF2/CCL2/MGST2/HMOX1/MEF2C/IL1R2/DUSP1/ICAM1/NFKB1/NCF1/IKBKB/HSP90AA1/MEF2A/IL1B/CALM2/PDGFB/RAC2/MAP2K4/MAP3K7/TNF/RELA/PIK3CD/CALM3/PIK3CB/ACVR2A/MGST1/IL1A/CTSL/MAPK7/MAP2K6/CYBA/RHOA/CHUK/FOS/KDR/CALML4/MAP3K5/NFE2L2/SQSTM1/JUN/SDC1	3.82850730680812
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	28/1638	83/9376	1.93100607558439	POLR3GL/POLR2K/IRF7/IL18/PYCARD/NFKB1/IKBKB/NFKBIB/POLR2F/GSDMD/POLR3K/IL1B/CASP1/POLR3C/CCL5/CCL4/SAMHD1/RELA/NLRP3/GSDME/NFKBIA/CXCL10/CHUK/ZBP1/ZDHHC1/POLR3B/AIM2/IL6	3.91960061333396
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	41/1638	138/9376	1.7006246571464	SPDYE2/CPEB3/ANAPC10/CDK1/CDC27/PPP2R5C/YWHAH/RBX1/MAP2K1/CPEB4/CALM2/SMC1A/PTTG1/AURKA/BUB1/RPS6KA3/FBXW11/BTRC/CCNB1/CALM3/RPS6KA1/ANAPC4/MAD1L1/CPEB2/MAD2L1/CDC25C/PLK1/CCNB2/YWHAQ/CAMK2D/FBXO5/CDC23/CAMK2G/PPP3CA/PPP3R1/SGO1/ESPL1/CDC20/CALML4/PKMYT1/ITPR2	3.81473352328892
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	37/1638	122/9376	1.73598350647531	PAK1/NCK1/NFKBIE/NFATC2/NFKB1/IKBKB/PPP2R5C/NFKBIB/PTPRC/LCP2/HRAS/MAP3K8/PPP2R2D/MAP2K1/NCK2/PPP2R2A/VAV1/CD4/GRB2/NRAS/MAP3K7/PTPN6/NFATC1/TNF/RELA/PIK3CD/PIK3CB/IL10/NFKBIA/RHOA/TEC1/CHUK/PPP3CA/PPP3R1/FOS/PPP2R2B/JUN	3.7645361662374
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	26/1638	77/9376	1.93279736136879	TGFBR1/STAT1/NFKB1/IKBKB/ARHGEF6/RALGDS/RB1/PLD1/CDK6/MAP2K1/RAC2/DDB2/BRCA2/RELA/CDKN2A/PIK3CD/GADD45G/BCL2L1/PIK3CB/TGFB1/TGFB2/GADD45B/BRAF/E2F3/CHUK/CASP9	3.78131425447686
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	24/1638	70/9376	1.96253270538985	HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DPA1/CD86/SGCE/HLA-F/CYCS/ICAM1/ITGB2/HLA-DRA/HLA-DRB1/HLA-DQA2/HLA-DPB1/RAC2/ABL2/HLA-DOA/HLA-DQB1/HLA-A/DMD/HLA-E/HLA-B/CASP9/HLA-C	3.71887186816572
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	31/1638	99/9376	1.79238045904713	CFH/HLA-DMA/HLA-DQA1/C3/C3AR1/KRT23/FPR3/HLA-DMB/HLA-DPA1/SELPLG/FPR1/FCGR2A/ICAM1/MASP1/ITGB2/HLA-DRA/HLA-DRB1/C1QB/CAMP/FCGR3A/HLA-DQA2/HLA-DPB1/C5AR1/HLA-DOA/C1QA/HLA-DQB1/C1QC/IL10/FCGR2B/KRT18/C5	3.64649649158284
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	44/1638	156/9376	1.61447669139977	MX1/STAT1/MX2/IRF9/IRF7/EIF2AK2/OAS2/OAS1/CYCS/RSAD2/NFKB1/IKBKB/IFIT1/OAS3/YWHAH/TICAM1/RB1/CDK6/HRAS/PPP2R2D/PIAS1/MAP2K1/PPP2R2A/CLDN4/GRB2/TRAF3/NRAS/CLDN20/TNF/TRAF6/RELA/PIK3CD/PIK3CB/BRAF/E2F3/NFKBIA/CXCL10/YWHAQ/CHUK/CLDN10/CLDN1/TLR3/PPP2R2B/CASP9	3.56065976040048
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	52/1638	193/9376	1.54223209145489	CCL8/CCL2/PAK1/STAT1/GRK3/RASGRP2/CXCR4/PREX1/ARRB2/CCL3/JAK2/DOCK2/GRK2/NFKB1/NCF1/IKBKB/TIAM1/WAS/NFKBIB/GRK5/ELMO1/HCK/LYN/CXCL3/HRAS/CXCL16/MAP2K1/VAV1/CCL5/PIK3CG/CCL4/RAC2/GRB2/NRAS/PIK3R5/CXCL2/RELA/PIK3CD/PIK3CB/GNG7/CCL23/GNG5/GNAQ/BRAF/FOXO3/ARRB1/NFKBIA/CXCL10/RHOA/CHUK/CCL21/PLCB2	3.50186825931991
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	13/1638	30/9376	2.48042328042328	PIGT/PIGF/PIGP/PIGS/PIGK/PIGV/PIGL/GPLD1/PIGB/PIGW/PGAP1/PIGG/B3GALT4	3.73647317942455
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	32/1638	106/9376	1.72801621858226	MMP9/PDGFC/PLAU/IL1R2/CREB1/NFKB1/CREB5/IKBKB/HSP90AA1/FOLR2/ETV5/RB1/HRAS/MAP2K1/PDGFB/GRB2/NRAS/RELA/PIK3CD/PIK3CB/CREB3/BRAF/PDGFD/E2F3/NFKBIA/CHUK/FGFR1/CREB3L1/SPINT1/SLC46A1/KLK3/CASP9	3.46802599654482
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	35/1638	120/9376	1.66951566951567	SH2B3/NFKBIE/RIPK2/ARHGDIB/NFKB1/IKBKB/NFKBIB/RAPGEF1/IRAK2/HRAS/MAP2K1/IRAK3/MAP3K3/CALM2/GRB2/NRAS/RPS6KA3/MAP3K1/TRAF6/RELA/PIK3CD/CALM3/PIK3CB/RPS6KA1/ZNF274/BRAF/FOXO3/NFKBIA/MAPK7/RHOA/CAMK2D/CAMK2G/CALML4/MAP3K5/JUN	3.39600186501254
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	18/1638	50/9376	2.06065934065934	TNFSF13B/HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DPA1/CD86/CXCR4/HLA-DRA/ITGA4/HLA-DRB1/TNFSF13/HLA-DQA2/HLA-DPB1/HLA-DOA/HLA-DQB1/TGFB1/IL10/IL6	3.45972390023436
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	18/1638	50/9376	2.06065934065934	CCL2/TLR2/IL18/ICAM1/ITGB2/TLR4/IL1B/GYPC/TNF/TGFB1/TGFB2/ACKR1/IL10/HGF/THBS1/CR1L/SDC1/IL6	3.45972390023436
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	20/1638	59/9376	1.94035719459448	NUDT2/UPP1/CDA/DCK/TYMS/RRM1/NT5C3A/DTYMK/TK1/RRM2B/CMPK2/ENTPD6/DPYD/RRM2/TK2/AK9/CANT1/NME7/ENTPD5/ENTPD3	3.33356581560391
Human Diseases	Immune disease	hsa05310	Asthma	13/1638	32/9376	2.32539682539683	HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DPA1/HLA-DRA/HLA-DRB1/HLA-DQA2/HLA-DPB1/HLA-DOA/TNF/HLA-DQB1/FCER1G/IL10	3.4552758482163
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	43/1638	160/9376	1.53833943833944	SIGLEC1/HLA-DMA/CD58/HLA-DQA1/CADM1/HLA-DMB/HLA-DPA1/CD86/ALCAM/HLA-F/SELPLG/ICAM1/CD22/NFASC/ITGB2/HLA-DRA/ITGA4/HLA-DRB1/ITGA6/NECTIN2/PTPRC/HLA-DQA2/HLA-DPB1/CLDN4/CD4/CLDN20/HLA-DOA/HLA-DQB1/F11R/PTPRD/HLA-A/PVR/ICAM2/ITGA9/JAML/CLDN10/HLA-E/HLA-B/CLDN1/SPN/SDC1/HLA-C/CDH3	3.15989884071827
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/1638	85/9376	1.75088702147526	NUDT16/HPRT1/UPP1/ADA2/CDA/AK2/DCK/TYMS/RRM1/NT5C3A/DTYMK/TK1/RRM2B/CMPK2/GMPR/ENTPD6/RRM2/TK2/LACC1/AK9/CANT1/NME7/ENTPD5/ENTPD3/AK5/ADSL	3.19949219431138
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	29/1638	98/9376	1.69385263262814	PAK1/SYK/PLA2G4C/FCGR2A/NCF1/INPP5D/WAS/HCK/PLA2G4A/PLD1/LYN/PTPRC/LIMK2/FCGR3A/ARPC1B/MAP2K1/VAV1/RAC2/SCIN/CFL2/PIK3CD/PLPP3/PIK3CB/PRKCE/ARPC3/PLA2G6/FCGR2B/SPHK1/ASAP1	3.17673741733938
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	28/1638	94/9376	1.70503727950536	MMP9/CCL2/FOSB/IL17RA/NFKB1/IKBKB/HSP90AA1/USP25/TAB2/CXCL3/IL1B/JUND/TNFAIP3/TRAF3/MAP3K7/CXCL2/TNF/TRAF6/RELA/PTGS2/NFKBIA/CXCL10/MAPK7/CHUK/FOS/CEBPB/JUN/IL6	3.16070126535074
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	24/1638	77/9376	1.7841206412635	TGFBR1/NFKB1/IKBKB/RB1/RUNX1/CDK6/HRAS/MAP2K1/GRB2/NRAS/DDB2/RELA/CDKN2A/PIK3CD/GADD45G/BCL2L1/PIK3CB/TGFB1/TGFB2/GADD45B/BRAF/E2F3/NFKBIA/CHUK	3.17861808023164
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	15/1638	41/9376	2.09416599660502	RBBP8/RPA3/RAD51C/NBN/TOPBP1/BRIP1/BRCA2/POLD3/MRE11/RAD51B/BABAM2/BLM/ABRAXAS1/BRCA1/RAD54L	3.23032490349083
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	29/1638	100/9376	1.65997557997558	HLA-DMA/CSF2RA/HLA-DQA1/CD37/HLA-DMB/HLA-DPA1/IL1R2/CD22/HLA-DRA/ITGA4/HLA-DRB1/ITGA6/HLA-DQA2/ITGA1/IL1B/HLA-DPB1/CD4/HLA-DOA/ITGA3/TNF/HLA-DQB1/MME/IL1A/CD9/CR1L/IL3RA/CD59/ANPEP/IL6	3.05264091311152
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	31/1638	110/9376	1.61314241314241	SPDYE2/CPEB3/PDE3B/ANAPC10/CDK1/HSP90AA1/CDC27/KIF22/CDC25B/STK10/MAP2K1/CPEB4/AURKA/BUB1/RPS6KA3/CCNB1/PIK3CD/PIK3CB/RPS6KA1/ANAPC4/MAD1L1/BRAF/CPEB2/MAD2L1/CCNA2/CDC25C/PLK1/CCNB2/FZR1/CDC23/PKMYT1	2.97604694530272
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	38/1638	142/9376	1.53178902474677	UBE2N/UBA6/ANAPC10/UBE2W/UBE2D1/PML/UBE2S/CDC27/UBE2C/UBE4B/UBE2E3/BIRC2/UBE2D2/RBX1/WWP1/PIAS1/ELOC/WWP2/DDB2/FBXW11/BTRC/MAP3K1/TRAF6/COP1/PRPF19/ANAPC4/NEDD4L/HERC2/UBE2J2/UBE2E1/UBE3B/FZR1/BRCA1/CDC23/FBXO4/CUL4B/CDC20/UBA7	2.93776350401815
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/1638	71/9376	1.77365044970679	ATP6AP1/PAK1/ATP6V1B2/ATP6V0B/ATP6V1E1/NFKB1/IKBKB/CSK/ATP6V0A1/LYN/ADAM17/ATP6V0C/CXCL3/ATP6V1F/CCL5/MAP2K4/CXCL2/RELA/F11R/NFKBIA/CHUK/JUN	3.01053715969922
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	18/1638	55/9376	1.87332667332667	SGMS1/GLA/SPTLC1/NEU1/ASAH1/HEXA/GM2A/SAMD8/CERK/PLPP3/KDSR/CERS6/SMPD1/PSAP/SPTLC3/SGPL1/SPHK1/GBA2	2.98851224514403
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	22/1638	72/9376	1.74901641568308	ISG15/IFIH1/IRF7/AZI2/PIN1/NFKB1/ATG5/IKBKB/NFKBIB/CYLD/TRAF3/MAP3K7/MAP3K1/TNF/TRAF6/RELA/TANK/NFKBIA/CASP10/CXCL10/CHUK/DDX3X	2.93528961138071
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	60/1638	250/9376	1.37377289377289	RAB11FIP1/TGFBR1/SMAP2/HSPA1B/GRK3/HSPA1A/HLA-F/CHMP1B/CHMP5/CXCR4/RAB5C/ARRB2/VPS36/VPS29/SMAP1/RAB11B/GRK2/PML/AGAP3/WIPF1/SNX5/FOLR2/WASHC1/RAB31/GRK5/GIT2/PLD1/WASHC4/VPS37A/VPS37B/WASHC2C/HRAS/AP2A2/ARPC1B/WWP1/CYTH1/MVB12B/CLTB/SH3KBP1/WASHC2A/GBF1/EPS15/TRAF6/NEDD4L/HSPA6/HLA-A/CYTH3/CHMP1A/ARFGAP2/AP2S1/STAMBP/IQSEC2/ARPC3/ARRB1/RHOA/ASAP1/HLA-E/HLA-B/AGAP5/HLA-C	2.75591487707407
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	21/1638	69/9376	1.7421033073207	ALOX5AP/ALOX5/SYK/PLA2G4C/INPP5D/PLA2G4A/LYN/LCP2/HRAS/MAP2K1/VAV1/MAP2K3/RAC2/GRB2/NRAS/MAP2K4/TNF/PIK3CD/FCER1G/PIK3CB/MAP2K6	2.84650715463342
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	15/1638	44/9376	1.95138195138195	POLE4/MBD4/PARP4/POLE3/POLD3/UNG/NEIL3/RFC3/TDP1/PCNA/LIG1/POLE/RFC5/POLB/POLE2	2.91019510297407
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	35/1638	133/9376	1.50632992738256	KLF2/DEPP1/TGFBR1/SGK1/SGK3/IKBKB/PLK3/CSNK1E/HRAS/BCL6/MAP2K1/TNFSF10/PRKAG2/NLK/GRB2/NRAS/CCNB1/PIK3CD/GADD45G/PIK3CB/TGFB1/PRKAG1/TGFB2/GADD45B/BRAF/HOMER2/IL10/FOXO3/PLK1/CCNB2/CHUK/GABARAP/G6PC3/PLK4/IL6	2.70570949659783
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	35/1638	133/9376	1.50632992738256	PAK1/SYK/ICAM1/LAT2/NFATC2/ITGB2/TYROBP/LCP2/FCGR3A/HRAS/HCST/MAP2K1/TNFSF10/VAV1/CD48/RAC2/GRB2/NRAS/IFNGR2/PTPN6/NFATC1/TNF/PIK3CD/FCER1G/TNFRSF10B/PIK3CB/KLRC3/HLA-A/BRAF/ICAM2/PPP3CA/PPP3R1/HLA-E/HLA-B/HLA-C	2.70570949659783
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	40/1638	157/9376	1.45835763670159	NDUFS7/NDUFB3/COX8A/ADIPOR1/CYCS/NDUFC1/NDUFS6/NFKB1/NDUFB5/IKBKB/NDUFA3/UQCR10/DDIT3/UQCRFS1/IL1B/MAP3K11/PRKAG2/UQCR11/UQCRQ/NDUFC2/COX7B/TNF/RELA/PIK3CD/COX6B1/PIK3CB/COX6A1/TGFB1/CEBPA/PRKAG1/IL1A/COX7A2/XBP1/FOS/NDUFB2/MT-CO2/NDUFA13/MAP3K5/JUN/IL6	2.66465270977816
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	31/1638	115/9376	1.54300578648405	MEF2C/SGK1/GNA13/PDE4B/ARRB2/CREB1/CREB5/OXSR1/NR4A2/MEF2A/PLD1/MAFB/ARHGEF11/MAP2K1/JUND/CREB3/ATF6B/GNAQ/BRAF/ARRB1/RHOA/STK39/FGFR1/BGLAP/CREB3L1/WNK2/FOS/GNAS/PLCB2/WNK3/ITPR2	2.69558269674452
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	8/1638	18/9376	2.54402387735721	MANBA/AGA/NEU1/MAN2B1/HEXA/MAN2B2/MAN2C1/GBA2	3.01666419384406
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	16/1638	49/9376	1.86907876703795	B4GALT1/ST6GAL1/C1GALT1/LFNG/GALNT1/GALNT2/ST3GAL3/POGLUT1/GALNT7/GALNT10/GALNT18/GXYLT1/ST6GAL2/EOGT/B3GLCT/FUT10	2.8061728302102
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	33/1638	125/9376	1.51115018315018	SGMS1/SPTLC1/GNA13/ORMDL2/CTSD/NFKB1/ASAH1/PPP2R5C/PLD1/ABCC1/HRAS/PPP2R2D/MAP2K1/PPP2R2A/RAC2/NRAS/TNF/ADORA3/RELA/PIK3CD/FCER1G/PIK3CB/CERS6/PRKCE/GNAQ/SMPD1/SPTLC3/SGPL1/RHOA/SPHK1/MAP3K5/PLCB2/PPP2R2B	2.64689925060427
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	64/1638	275/9376	1.33214341214341	NDUFS7/HSPA1B/NDUFB3/HSPA1A/COX8A/NCF4/SLC25A5/CYCS/NDUFC1/CREB1/NDUFS6/CSNK2B/NCF1/CREB5/NDUFB5/ADRM1/NDUFA3/C1QB/ATP5F1C/PSMA1/UQCR10/DDIT3/UQCRFS1/IL1B/PSMA4/TUBB2A/UQCR11/CCL5/RAC2/UQCRQ/NDUFC2/COX7B/TUBA1C/TNF/C1QA/PIK3CD/PSMD6/COX6B1/PIK3CB/COX6A1/C1QC/NOTCH1/CREB3/HSPA6/ATF6B/RYR1/IL1A/TUBA1B/COX7A2/ATP5PF/CYBA/TUBA3E/TUBB4B/PPP3CA/PPP3R1/CREB3L1/NDUFB2/MT-CO2/C5/NDUFA13/TUBB/CASP9/IL6/ITPR2	2.57202779091066
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	26/1638	93/9376	1.60027308414405	CKS2/CYCS/NFKB1/IKBKB/ITGA6/CKS1B/RB1/BIRC2/CDK6/TRAF3/DDB2/ITGA3/TRAF6/RELA/PIK3CD/GADD45G/BCL2L1/PIK3CB/PTGS2/GADD45B/LAMC3/E2F3/NFKBIA/CHUK/FHIT/CASP9	2.67654403935986
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	17/1638	54/9376	1.80201691312802	HLA-DMA/HLA-DQA1/HLA-DMB/HLA-DPA1/CD86/HLA-F/HLA-DRA/HLA-DRB1/HLA-DQA2/HLA-DPB1/HLA-DOA/HLA-DQB1/HLA-A/IL10/HLA-E/HLA-B/HLA-C	2.71928095929943
Human Diseases	Cancer: specific types	hsa05214	Glioma	22/1638	76/9376	1.65696292012082	CAMK1D/RB1/CDK6/HRAS/MAP2K1/CALM2/CAMK1/PDGFB/GRB2/NRAS/DDB2/CDKN2A/PIK3CD/GADD45G/CALM3/PIK3CB/GADD45B/BRAF/E2F3/CAMK2D/CAMK2G/CALML4	2.64566227186069
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	43/1638	174/9376	1.4145650007719	HSPA1B/HSPA1A/ATF6/DERL1/UBE2D1/HSP90AA1/KRTCAP2/UBE4B/ERP29/GANAB/SEC24B/RNF5/DDIT3/UBE2D2/RBX1/SEC13/SIL1/EDEM1/NGLY1/SEC23B/DNAJB1/ERO1B/SEC23A/UBXN2A/RPN2/HSPA6/SEC61G/ATF6B/FBXO6/WFS1/UBE2J2/HSPH1/UBQLN2/PPP1R15A/XBP1/RNF185/SVIP/SEL1L2/MAN1A1/MAP3K5/NFE2L2/UBXN8/DERL3	2.53953596868434
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	75/1638	333/9376	1.28920128920129	ISG15/MX1/ATP6AP1/PTGER4/WNT6/STAT1/MX2/ATP6V1B2/IRF9/WNT4/EIF2AK2/HLA-F/ATP6V0B/TUBG1/ATP6V1E1/MAML3/CREB1/NFKB1/CREB5/IKBKB/ITGA4/PPP2R5C/ITGA6/ATP6V0A1/TICAM1/VTN/RB1/ATP6V0C/EIF4EBP1/CDK6/HRAS/OASL/ITGA1/PPP2R2D/MAP2K1/ATP6V1F/PPP2R2A/CCND3/LFNG/RHEB/GRB2/TRAF3/NRAS/ITGA3/TNF/RELA/PIK3CD/PIK3CB/NOTCH1/CREB3/HLA-A/PTGS2/RBL1/LAMC3/ITGA9/FZD3/CCNA2/MAML1/FZD2/CHUK/FZD1/DLG2/HLA-E/CREB3L1/WNT2B/HLA-B/GNAS/MAML2/TLR3/THBS1/AXIN1/PPP2R2B/SCRIB/DVL2/HLA-C	2.47226089908465
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	17/1638	56/9376	1.73765916623059	MGAT4A/MGAT1/B4GALT1/ST6GAL1/KRTCAP2/SRD5A3/GANAB/ALG2/DHRSX/ALG3/MAN2A1/RPN2/ALG6/ST6GAL2/ALG14/MAN2A2/MAN1A1	2.54724093235428
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	39/1638	158/9376	1.41289933694997	WNT6/SGK1/ATP6V1B2/WNT4/ATP6V1E1/DEPTOR/IKBKB/EIF4EBP1/HRAS/SEC13/MAP2K1/ATP6V1F/RHEB/GRB2/NRAS/RPS6KA3/FNIP2/TNF/EIF4E/PIK3CD/LAMTOR5/PIK3CB/RPS6KA1/STRADA/SLC7A5/LAMTOR4/BRAF/MLST8/FZD3/MIOS/FZD2/RHOA/CHUK/SLC38A9/FZD1/GRB10/WNT2B/TELO2/DVL2	2.40814482266447
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	36/1638	144/9376	1.43101343101343	LY96/C3/C3AR1/ADIPOR1/IL17RA/ALDH2/NFKB1/IKBKB/TRA2B/C1QB/TLR4/TICAM1/TAB2/CXCL3/IL1B/C5AR1/PRKAG2/MAP2K3/TRAF3/MAP2K4/MAP3K7/CXCL2/TNF/C1QA/TRAF6/RELA/C1QC/PRKAG1/FOXO3/ACOX3/NFKBIA/MAP2K6/CHUK/C5/MAP3K5/IL6	2.39801765386413
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	14/1638	44/9376	1.82128982128982	CCNH/GTF2A2/TAF9/GTF2H5/TAF3/GTF2B/GTF2H1/GTF2A1/TAF6/TAF8/GTF2E1/TAF4/TAF5L/GTF2H4	2.51225452886538
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/1638	20/9376	2.28962148962149	FDFT1/SOAT1/LBR/SQLE/TM7SF2/MSMO1/EBP/DHCR24	2.65619758114929
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	41/1638	169/9376	1.38867575553966	C9orf72/ATG3/DAPK1/VAMP8/STX7/CTSD/DEPTOR/ATG5/MRAS/NRBF2/ATG4C/ATG10/WDR45B/HRAS/MAP2K1/RHEB/UVRAG/ATG2B/NRAS/MAP3K7/ATG16L2/TRAF6/PIK3CD/BCL2L1/PIK3CB/EPG5/ATG7/ATG9B/TANK/CTSL/VPS18/MLST8/RAB1A/VPS33A/GABARAP/ATG2A/VMP1/ATG4D/CTSB/SQSTM1/HIF1A	2.34584847515621
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	26/1638	98/9376	1.51862649821834	NR4A1/CAMK1D/ATP1A1/CREB1/CREB5/NR4A2/CALM2/CAMK1/ATP1B3/DAGLB/CALM3/CREB3/ATF6B/PRKCE/ORAI1/GNAQ/ATP2B1/ATP2B3/CAMK2D/CAMK2G/CREB3L1/GNAS/CALML4/PLCB2/DAGLA/ITPR2	2.37448144611544
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	11/1638	32/9376	1.96764346764347	ATG3/ATG5/ATG4C/ATG10/ATG2B/ATG7/ATG9B/MLST8/GABARAP/ATG2A/ATG4D	2.5226219343265
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/1638	227/9376	1.31123697643521	AHR/MGST2/HMOX1/NDUFS7/NDUFB3/COX8A/SLC25A5/NDUFC1/AKR1A1/NDUFS6/NFKB1/NCF1/NDUFB5/IKBKB/NDUFA3/ATP5F1C/UQCR10/PLD1/HRAS/UQCRFS1/MAP2K1/PTPN1/UQCR11/GRB2/UQCRQ/NDUFC2/NRAS/MAP2K4/ABL2/COX7B/RELA/PIK3CD/COX6B1/PIK3CB/COX6A1/MGST1/BRAF/FOXO3/COX7A2/NFKBIA/ATP5PF/CYBA/CHUK/FOS/HGF/NDUFB2/MT-CO2/NDUFA13/MAP3K5/NFE2L2/HIF1A/JUN	2.18396425838287
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/1638	68/9376	1.59936795230913	DUSP6/SPI1/NFKB1/PML/IKBKB/RUNX1/EIF4EBP1/HRAS/MAP2K1/GRB2/NRAS/RELA/PIK3CD/PIK3CB/CEBPA/PPARD/BRAF/CCNA2/CHUK	2.28217010004558
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	23/1638	87/9376	1.5132555822211	TGFBR1/PMAIP1/CYCS/RALGDS/HRAS/MAP2K1/RAC2/GRB2/NRAS/DDB2/PIK3CD/GADD45G/PIK3CB/TGFB1/BIRC5/TGFB2/GADD45B/BRAF/RHOA/FOS/AXIN1/JUN/CASP9	2.21277395279952
Organismal Systems	Endocrine system	hsa04924	Renin secretion	19/1638	69/9376	1.57618870662349	REN/PTGER4/PDE3B/CREB1/CALM2/KCNMA1/CALM3/ORAI1/GNAQ/ADRB2/PPP3CA/PPP3R1/GNAS/CALML4/PDE3A/PLCB2/CTSB/PDE1B/ITPR2	2.21010371419078
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	27/1638	107/9376	1.44438738831262	PPP4C/PDE3B/CREB1/CREB5/SIK2/PHKB/CALM2/PRKAG2/CALM3/PRKAG1/CREB3/PDHB/PHKG2/GNAQ/GYS1/CAMK2D/CAMK2G/PPP3CA/PPP3R1/G6PC3/CREB3L1/GNAS/CALML4/PLCB2/CRTC2/PHKA2/ITPR2	2.12698975068521
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	24/1638	93/9376	1.47717515459451	PLA2G4C/PLA2G4A/PLD1/MAP3K2/HRAS/MAP2K1/MAP3K3/CALM2/MAP2K3/GRB2/NRAS/MAP2K4/MAP3K1/CALM3/GNAQ/MAPK7/MAP2K6/CAMK2D/CAMK2G/GNAS/CALML4/PLCB2/JUN/ITPR2	2.12766547342653
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	26/1638	103/9376	1.44490676529511	TLR2/IL1R2/RAB5C/NFKB1/ITGB2/TLR4/GNA15/CXCL3/IL1B/SERPINB9/CXCL2/TNF/RELA/PIK3CD/ARG1/PIK3CB/TGFB1/TGFB2/GNAQ/LAMC3/IL10/ARG2/GNAS/PLCB2/GNAL/IL6	2.08884260224
NA	NA	hsa04517	IgSF CAM signaling	65/1638	299/9376	1.24435950522907	PAK1/SRGAP1/NCK1/MBP/CD84/CADM1/CD86/UNC5B/EPB41L3/ICAM1/NFASC/ITGB2/RASA1/INPP5D/ITGA4/SRGAP2/RAPGEF6/IL1RAP/NECTIN2/CSK/NRP2/LYN/LCP2/LMO7/ARPC1B/MAP2K1/PPFIA1/NCK2/VAV1/CD48/TUBB2A/CABLES1/GRB2/RAPGEF2/TUBA1C/PTPN6/TRAF6/PIK3CD/MYH10/PIK3CB/RDX/F11R/DOK1/MPDZ/PTPRD/LRFN4/PVR/TUBA1B/ICAM2/ARPC3/IQGAP1/EPB41L2/TRIO/RHOA/JAML/TUBA3E/FGFR1/TUBB4B/KDR/TUBB/BAIAP2/PLXNA4/MYLK3/MYL12A/KCNA4	1.97570403937299
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	82/1638	388/9376	1.20972269425878	NDUFS7/WNT6/NDUFB3/COX8A/WNT4/EIF2AK2/SLC25A5/ATF6/CYCS/NDUFC1/NDUFS6/PSENEN/CSNK2B/NFKB1/NDUFB5/IKBKB/ADRM1/NDUFA3/SLC39A11/NRBF2/ATP5F1C/PSMA1/UQCR10/ADAM17/DDIT3/SNCA/CSNK1E/NCSTN/HRAS/UQCRFS1/IL1B/SLC39A4/MAP2K1/CALM2/PSMA4/TUBB2A/UQCR11/ATG2B/UQCRQ/NDUFC2/NRAS/COX7B/TUBA1C/TNF/RELA/PIK3CD/PSMD6/CALM3/COX6B1/PIK3CB/COX6A1/MME/PTGS2/GNAQ/BRAF/IL1A/TUBA1B/FZD3/COX7A2/ATP5PF/XBP1/FZD2/TUBA3E/CHUK/TUBB4B/FZD1/PPP3CA/PPP3R1/ATG2A/WNT2B/NDUFB2/MT-CO2/CALML4/NDUFA13/TUBB/MAP3K5/PLCB2/AXIN1/DVL2/CASP9/IL6/ITPR2	1.94114502634055
NA	NA	hsa04981	Folate transport and metabolism	10/1638	31/9376	1.84646894324314	SLCO2B1/FOLR2/ABCC3/TYMS/ABCC1/DHFR/SHMT2/SHMT1/MTHFD1/SLC46A1	2.17185309894312
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	13/1638	44/9376	1.69119769119769	MGAT4A/MGAT1/B4GALT1/HEXA/KRTCAP2/ALG2/ST3GAL3/ALG3/MAN2A1/RPN2/ALG14/MAN2A2/MAN1A1	2.11431395475669
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	46/1638	204/9376	1.29071799660035	MMP9/TLR2/PAK1/WNT6/PLAU/PLAUR/WNT4/HCLS1/TIAM1/MRAS/TLR4/VTN/HRAS/MAP2K1/VAV1/GRB2/NRAS/PTPN6/TNF/PIK3CD/PIK3CB/RDX/TGFB1/PPP1R12B/ESR1/TGFB2/BRAF/CTSL/FZD3/IQGAP1/FZD2/RHOA/CAMK2D/FGFR1/FZD1/HPSE/CAMK2G/KDR/WNT2B/HGF/IGF2/THBS1/TFAP4/HIF1A/SDC1/ITPR2	1.93144880874517
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	36/1638	154/9376	1.33809048094762	TPK1/PTS/AKR1A1/ALDH2/KYNU/KMO/AK2/MTHFD2/NADK/DHFR/GGH/DHRS3/CMPK2/GMPPB/GCH1/GCLC/UGDH/SHMT2/NADSYN1/MAT2B/ALAS1/MTHFD1L/AK9/SHMT1/NME7/ALAD/HSD17B6/RDH13/FLAD1/BCAT2/AK5/ADSL/PPOX/MTHFD2L/MTHFD1/COQ3	1.94629635330077
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	36/1638	154/9376	1.33809048094762	MEF2C/CAMK1D/PLA2G4C/NFATC2/PLA2G4A/TRPM2/HRAS/MAP2K1/CALM2/CAMK1/PRKAG2/PIK3CG/NRAS/PIK3R5/NFATC1/CALM3/CACNA2D3/PPP1R12B/PRKAG1/PTGS2/RYR1/GNAQ/MAPK7/RHOA/CAMK2D/CAMK2G/PPP3CA/PPP3R1/FOS/GNAS/CALML4/CACNB4/PLCB2/MYLK3/JUN/ITPR2	1.94629635330077
Human Diseases	Cancer: specific types	hsa05218	Melanoma	19/1638	73/9376	1.48982220215097	PDGFC/RB1/CDK6/HRAS/MAP2K1/MITF/PDGFB/NRAS/DDB2/CDKN2A/PIK3CD/GADD45G/PIK3CB/GADD45B/BRAF/PDGFD/E2F3/FGFR1/HGF	1.93293215285541
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	19/1638	73/9376	1.48982220215097	RB1/CDK6/HRAS/MAP2K1/GRB2/NRAS/DDB2/CDKN2A/PIK3CD/GADD45G/PIK3CB/RASSF5/GADD45B/BRAF/FOXO3/E2F3/FHIT/HGF/CASP9	1.93293215285541
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	38/1638	166/9376	1.31032555128941	MEF2C/ATP1A1/GNA13/SLC25A5/PDE3B/CREB1/NFATC2/CREB5/MEF2A/MAP2K1/CALM2/KCNMA1/ATP1B3/PIK3CG/KCNMB1/PIK3R5/NFATC1/ADORA3/CALM3/CREB3/ATF6B/PRKCE/GNAQ/ATP2B1/ADRB2/RHOA/KCNMB4/ATP2B3/PPP3CA/PPP3R1/CREB3L1/CALML4/PDE3A/PLCB2/MYLK3/SRF/ITPR2/KCNJ8	1.85596588349592
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/1638	28/9376	1.83987441130298	TECR/ELOVL1/HACD4/PPT1/ACOT7/HADH/HACD2/ELOVL5/MECR	2.04768070360078
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	55/1638	253/9376	1.24435950522907	UBE2N/C3/RIPK2/IL18/CYCS/HCLS1/PYCARD/UBE2D1/NFKB1/ATG5/IKBKB/TLR4/NFKBIB/ELMO1/TLR5/TAB2/UBE2D2/RBX1/IL1B/ARPC1B/CYTH1/CASP1/CCL5/FBXW11/BTRC/MAP3K7/CASP4/TNF/DIAPH1/TLN2/TRAF6/RELA/PIK3CD/TIFA/BCL2L1/NLRP3/PIK3CB/PRKCE/GLMN/CYTH3/FOXO3/ARPC3/NFKBIA/RHOA/CHUK/RNF31/U2AF1/U2AF1L4/PLCB2/HK3/PFN1/SQSTM1/MYL12A/JUN/ITPR2	1.81279579236923
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	18/1638	69/9376	1.49323140627488	FOSB/MAOA/CREB1/CREB5/CALM2/CALM3/CREB3/ATF6B/MAOB/CAMK2D/CAMK2G/PPP3CA/PPP3R1/CREB3L1/FOS/GNAS/CALML4/JUN	1.89190199396946
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	16/1638	60/9376	1.52641432641433	PLA2G4C/NFATC2/PLA2G4A/MAPKAPK3/HRAS/MAP2K1/RAC2/NRAS/PIK3CD/PIK3CB/PTGS2/SPHK1/PPP3CA/PPP3R1/KDR/CASP9	1.88198782525462
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/1638	33/9376	1.73456173456173	STX11/VAMP8/STX7/SNAP23/VAMP2/STX8/STX6/STX18/VAMP7/STX3	1.94477928835999
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	18/1638	70/9376	1.47189952904239	PAK1/EGLN2/RAPGEF1/HRAS/RBX1/MAP2K1/ELOC/PDGFB/GRB2/NRAS/PIK3CD/PIK3CB/TGFB1/TGFB2/BRAF/HGF/HIF1A/JUN	1.823245977336
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	24/1638	99/9376	1.38764938764939	PDGFC/PLA2G4C/LYPLA1/WAS/RALGDS/PLA2G4A/PLD1/EIF4EBP1/HRAS/MAP2K1/SLC44A2/RHEB/PDGFB/RAC2/GRB2/NRAS/PIK3CD/PLPP3/PIK3CB/PDGFD/FOS/DGKG/HIF1A/JUN	1.78394370518375
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	34/1638	149/9376	1.30615991018676	PDGFC/SYK/GNA13/PLA2G4C/LPAR6/AGPAT1/MRAS/AGPAT3/RALGDS/PLA2G4A/PLD1/HRAS/CYTH1/MAP2K1/PIK3CG/RHEB/PDGFB/GRB2/NRAS/PIK3R5/AGPAT4/PIK3CD/PLPP3/FCER1G/PIK3CB/CYTH3/PDGFD/RHOA/LPAR5/SPHK1/GRM7/GNAS/DGKG/PLCB2	1.73316304350342
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	32/1638	139/9376	1.31776776381093	MMP9/HSPA1B/KRT23/HSPA1A/FKBP5/CREB1/CTSD/CREB5/HSP90AA1/NCOA3/NCOA2/HRAS/MAP2K1/CALM2/GRB2/NRAS/PIK3CD/CALM3/PIK3CB/CREB3/HSPA6/ATF6B/ESR1/GNAQ/CREB3L1/FOS/KRT18/GNAS/CALML4/PLCB2/JUN/ITPR2	1.73652080266277
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	57/1638	268/9376	1.21742933683232	NDUFS7/NDUFB3/COX8A/MAOA/SLC25A5/ATF6/CYCS/DUSP1/NDUFC1/NDUFS6/NDUFB5/ADRM1/NDUFA3/SLC39A11/ATP5F1C/PSMA1/UQCR10/DDIT3/SNCA/UQCRFS1/SLC39A4/CALM2/PSMA4/TUBB2A/UQCR11/UQCRQ/NDUFC2/COX7B/TUBA1C/PSMD6/CALM3/BCL2L1/COX6B1/COX6A1/TUBA1B/UBE2J2/MAOB/COX7A2/ATP5PF/XBP1/TUBA3E/CAMK2D/TUBB4B/CAMK2G/LRRK2/NDUFB2/GNAS/MT-CO2/CALML4/NDUFA13/TUBB/MAP3K5/UBA7/NFE2L2/GNAL/CASP9/ITPR2	1.66150729147294
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1638	34/9376	1.68354521295698	POLR3GL/POLR2K/POLR2J/POLR2I/POLR2J3/POLR2F/POLR3K/POLR3C/POLR1E/POLR3B	1.83702470727003
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	24/1638	101/9376	1.36017118195336	CCL2/TGFBR1/STAT1/ICAM1/JAK2/NFKB1/SERPINE1/HRAS/IL1B/NRAS/NFATC1/TNF/DIAPH1/RELA/PIK3CD/F3/PIK3CB/TGFB1/PRKCE/TGFB2/IL1A/PLCB2/JUN/IL6	1.67432943792725
Organismal Systems	Immune system	hsa04611	Platelet activation	29/1638	126/9376	1.31744093648856	TBXAS1/VAMP8/SYK/RASGRP2/GNA13/SNAP23/PLA2G4C/FCGR2A/PLA2G4A/LYN/LCP2/PIK3CG/PTGS1/FERMT3/PIK3R5/TLN2/PIK3CD/FCER1G/PIK3CB/ORAI1/GNAQ/GP6/RHOA/GNAS/PLCB2/MYLK3/P2RY12/MYL12A/ITPR2	1.65046212334903
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	13/1638	49/9376	1.51862649821834	FOSB/MAOA/CREB1/NFKB1/CREB5/GPSM1/RELA/CREB3/ATF6B/MAOB/CREB3L1/GNAS/JUN	1.67459572541116
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	14/1638	54/9376	1.48401392845837	RPA3/RAD51C/ERCC1/CENPX/BRIP1/USP1/BRCA2/FANCB/FANCD2/BLM/UBE2T/BRCA1/FANCA/TELO2	1.64107494262091
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/1638	83/9376	1.37929005398885	L3MBTL4/SUZ12/CSNK2B/UBE2D1/SFMBT1/UBE2D2/SCMH1/AURKB/PHF19/CBX4/FOXK2/RING1/PHF1/FBRSL1/EZH2/FBRS/KDM2B/RNF2/WDR5/BAP1	1.59683762247522
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1638	31/9376	1.66182204891882	SEC11C/SRP19/OXA1L/GET3/SPCS3/BAG6/SEC61G/UBL4A/IMMP2L	1.69808978742456
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	21/1638	88/9376	1.36596736596737	CFH/C3/C3AR1/PLAU/PLAUR/CLU/MASP1/SERPING1/ITGB2/C1QB/VTN/SERPINE1/C5AR1/C1QA/F3/C1QC/F12/SERPINB2/C5/CR1L/CD59	1.5869045930974
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	44/1638	205/9376	1.22857738467495	REN/MMP9/TGFBR1/NDUFS7/TBC1D4/NDUFB3/COX8A/NCF4/SLC25A5/NDUFC1/NDUFS6/CTSD/NFKB1/NCF1/NDUFB5/NDUFA3/ATP5F1C/UQCR10/UQCRFS1/UQCR11/RAC2/UQCRQ/NDUFC2/COX7B/RELA/PIK3CD/COX6B1/PIK3CB/COX6A1/TGFB1/PDHB/TGFB2/COX7A2/ATP5PF/PDK4/GYS1/CYBA/PDK2/CAMK2D/CAMK2G/NDUFB2/MT-CO2/NDUFA13/PLCB2	1.52240452928272
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	25/1638	108/9376	1.32501243612355	TMEM33/MAGOH/UPF3B/CSE1L/RANGAP1/NXT1/SEC13/UPF1/RANBP2/XPO6/KPNA2/THOC1/EIF4A3/NUP98/XPO7/NUP35/NUP93/NUP37/XPO4/IPO11/THOC6/THOC3/NUP85/NUP210/IPO13	1.56295713836565
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1638	59/9376	1.45526789594586	MGST2/PGD/SMS/GGT5/RRM1/HPGDS/IDH1/IDH2/RRM2B/GCLC/LAP3/RRM2/MGST1/GPX4/ANPEP	1.61392447847599
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	43/1638	201/9376	1.22454880663836	MMP9/IGFBP3/MEF2C/BMP2K/ETV6/PLAU/NR4A3/DUSP6/CD86/SPI1/IL1R2/FLI1/CDK14/NFKB1/KLF3/PML/ETV5/CDKN2C/MLF1/BIRC2/RUNX1/DDIT3/LYL1/BCL6/NSD2/MITF/PBX3/HHEX/DDB2/LMO2/RELA/GADD45G/BCL2L1/CEBPA/GADD45B/ID2/CCNA2/CDK9/REL/SPINT1/CEBPB/LDB1/IL6	1.48058712270915
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	21/1638	89/9376	1.35061941803515	PDGFC/CDK1/MAP3K2/HRAS/MAP2K1/TUBB2A/PDGFB/GRB2/HTR2B/NRAS/TUBA1C/GNAQ/TUBA1B/PDGFD/MAPK7/TUBA3E/TUBB4B/GNAS/TUBB/PLCB2/ITPR2	1.52904923329675
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	45/1638	212/9376	1.21501140369065	PDGFC/FYB1/SIPA1L1/RASGRP2/FPR1/ID1/ITGB2/TIAM1/MRAS/CNR1/RAPGEF6/RALGDS/RAPGEF1/LCP2/HRAS/MAP2K1/CALM2/VAV1/MAP2K3/PDGFB/RAC2/NRAS/RAPGEF2/SIPA1L3/TLN2/PIK3CD/CALM3/DOCK4/PIK3CB/RASSF5/GNAQ/BRAF/PDGFD/MAP2K6/RHOA/LPAR5/FGFR1/KDR/HGF/GNAS/CALML4/EFNA4/THBS1/PLCB2/PFN1	1.4568509077081
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/1638	23/9376	1.7421033073207	RPA3/POLD3/RFC3/PCNA/LIG1/RFC5/EXO1	1.6393853211978
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/1638	23/9376	1.7421033073207	REN/CTSA/PRCP/LNPEP/MME/THOP1/ANPEP	1.6393853211978
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1638	80/9376	1.35946275946276	PDGFC/GAS6/JAK2/EIF4EBP1/HRAS/MAP2K1/PDGFB/GRB2/NRAS/EIF4E/PIK3CD/BCL2L1/PIK3CB/BRAF/FOXO3/PDGFD/KDR/HGF/IL6	1.48552191851783
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	13/1638	51/9376	1.45907251789605	AGPS/PLA2G4C/PLD4/LPCAT2/PLA2G7/PLA2G4A/PLD1/PLD3/PLPP3/PLA2G2A/PLA2G6/PLB1/TMEM86B	1.51241225158635
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	10/1638	37/9376	1.54704154704155	APOA1/IL18/ICAM1/IL1B/TNF/GNAQ/IL10/PLCB2/THOP1/IL6	1.53390763871598
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	49/1638	235/9376	1.19352609565376	NDUFS7/NDUFB3/COX8A/NDUFAF3/NDUFC1/CREB1/NDUFS6/CREB5/NDUFB5/COX20/ATP5MF/NDUFA3/PLIN1/CNR1/ATP5F1C/COX19/UQCR10/HRAS/UQCRFS1/ACSL1/PNPLA2/PRKAG2/MAP2K3/UQCR11/RHEB/GRB2/UQCRQ/NDUFC2/NRAS/RPS6KA3/COX7B/COX6B1/COX6A1/RPS6KA1/PRKAG1/CREB3/MLST8/SMARCD1/COX7A2/ATP5PF/FGFR1/CREB3L1/NDUFAF1/NDUFB2/GNAS/MT-CO2/ARID1B/NDUFA13/MAP3K5	1.38230804557206
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/1638	28/9376	1.63544392115821	PCBD1/AKR1B1/PTS/PCBD2/QDPR/DHFR/GGH/GCH1	1.5492628874803
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	17/1638	71/9376	1.37054807477343	PRL/STAT1/JAK2/NFKB1/HRAS/MAP2K1/GRB2/CISH/NRAS/RELA/PIK3CD/SOCS6/PIK3CB/ESR1/FOXO3/PRLR/FOS	1.44192865005533
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	36/1638	168/9376	1.22658294086866	STAT1/IRF9/EIF2AK2/CHMP1B/CHMP5/SLC25A5/PLA2G4C/JAK2/PYCARD/HSP90AA1/TLR4/TICAM1/PLA2G4A/BIRC2/FTH1/IL1B/CASP1/TNFSF10/TNFAIP3/GLUL/CYLD/IFNGR2/TNF/NLRP3/TNFRSF10B/GLUD1/TICAM2/CHMP1A/IL1A/SMPD1/CAMK2D/CAMK2G/RNF31/ZBP1/TLR3/SQSTM1	1.36341296369424
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	48/1638	232/9376	1.18428697739043	RGCC/PDGFC/PAK1/GNA13/CXCR4/IQGAP2/ITGB2/TIAM1/ITGA4/MRAS/ARHGEF6/ITGA6/NCKAP1L/LIMK2/HRAS/ITGA1/ARPC1B/MAP2K1/VAV1/PDGFB/RAC2/NRAS/SCIN/ITGA3/DIAPH1/CFL2/PIK3CD/ARHGEF7/SSH2/MYH10/PIK3CB/RDX/DIAPH3/PPP1R12B/SPATA13/BRAF/ITGA9/PDGFD/ARPC3/IQGAP1/RHOA/LPAR5/FGFR1/C5/BAIAP2/MYLK3/PFN1/MYL12A	1.30767178996231
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1638	67/9376	1.3669382027591	HRAS/MAP2K1/CALM2/NRAS/RPS6KA3/CALM3/RPS6KA1/GNAQ/BRAF/CAMK2D/CAMK2G/PPP3CA/PPP3R1/CALML4/PLCB2/ITPR2	1.38677830832334
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	30/1638	138/9376	1.24435950522907	NDUFS7/ATP6AP1/NDUFB3/ATP6V1B2/COX8A/ATP6V0B/ATP6V1E1/CYCS/NDUFC1/NDUFS6/NDUFB5/ATP5MF/NDUFA3/ATP5F1C/ATP6V0A1/UQCR10/ATP6V0C/UQCRFS1/ATP6V1F/UQCR11/UQCRQ/NDUFC2/COX7B/COX6B1/COX6A1/COX7A2/ATP5PF/NDUFB2/MT-CO2/NDUFA13	1.33047900444767
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	29/1638	133/9376	1.24810193983126	MAOA/ARRB2/CREB1/CREB5/COMT/PPP2R5C/PPP2R2D/CALM2/PPP2R2A/CLOCK/CALM3/GNG7/CREB3/ATF6B/GNG5/GNAQ/MAOB/ARRB1/CAMK2D/CAMK2G/PPP3CA/CREB3L1/FOS/GNAS/CALML4/PLCB2/PPP2R2B/GNAL/ITPR2	1.32579912508035
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	36/1638	170/9376	1.21215255332902	HCLS1/TIAM1/WAS/RAPGEF6/RUNX1/PPP2R2D/ARPC1B/PPP2R2A/PRKAG2/ARHGEF18/CLDN4/CLDN20/MAP3K1/RAPGEF2/TUBA1C/MYH10/RDX/PRKAG1/F11R/MPDZ/NEDD4L/PRKCE/SYMPK/TUBA1B/ARPC3/PCNA/RHOA/TUBA3E/CLDN10/DLG2/CLDN1/MAP3K5/PPP2R2B/SCRIB/MYL12A/JUN	1.28429698392539
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/1638	20/9376	1.71721611721612	CYB5R1/GMPPB/GMDS/UGDH/CYB5RL/UAP1L1	1.47723012608132
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	72/1638	362/9376	1.1384858235687	PRL/PDGFC/TLR2/NR4A1/SGK1/SYK/LPAR6/SGK3/JAK2/CREB1/NFKB1/CREB5/IKBKB/HSP90AA1/ITGA4/PPP2R5C/TLR4/ITGA6/PIK3AP1/YWHAH/VTN/EIF4EBP1/CDK6/HRAS/PKN2/ITGA1/PPP2R2D/MAP2K1/PPP2R2A/CCND3/PIK3CG/RHEB/PDGFB/GRB2/NRAS/PIK3R5/ITGA3/EIF4E/RELA/PIK3CD/BCL2L1/PIK3CB/GNG7/CREB3/ATF6B/GNG5/OSM/LAMC3/MLST8/FOXO3/ITGA9/PDGFD/PRLR/GYS1/YWHAQ/LPAR5/CHUK/BRCA1/FGFR1/PHLPP1/G6PC3/CREB3L1/KDR/HGF/IGF2/EFNA4/THBS1/CRTC2/PPP2R2B/IL3RA/CASP9/IL6	1.23631475007933
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	17/1638	73/9376	1.33299881245087	MX1/BST2/MX2/MDFIC/CXCR4/PSIP1/PIN1/CPSF6/BICD1/ELL2/CD4/RANBP2/SAMHD1/BICD2/NELFCD/CDK9/KAT2A	1.31407704392004
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	33/1638	155/9376	1.21866950254047	AHR/NR4A1/WNT6/NCEH1/WNT4/CREB1/CREB5/CDKN2C/RB1/CDK6/MAP2K1/CDKN2A/CREB3/ATF6B/ORAI1/GNAQ/BRAF/E2F3/FZD3/FZD2/WDR5/CAMK2D/FZD1/CAMK2G/CREB3L1/WNT2B/GNAS/PLCB2/ARMC5/AXIN1/DVL2/KCNA4/ITPR2	1.26297071132174
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	10/1638	39/9376	1.4677060830907	MTHFD2/TYMS/DHFR/SHMT2/MAT2B/MTHFD1L/SHMT1/AHCYL2/MTHFD2L/MTHFD1	1.3465728901837
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	24/1638	109/9376	1.2603421043788	TBC1D4/CREB1/NFKB1/CREB5/IKBKB/PTPN1/PRKAG2/RPS6KA3/TNF/RELA/PIK3CD/PIK3CB/RPS6KA1/PRKAG1/CREB3/PRKCE/NFKBIA/GYS1/G6PC3/CREB3L1/CRTC2/IL6/PPARGC1B/SLC27A6	1.2578136477164
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	23/1638	104/9376	1.26589649666573	SGMS1/PLA2G4C/PLPP5/LYPLA1/AGPAT1/PLD4/LPCAT2/GPD2/AGPAT3/PLA2G4A/PLD1/PLD3/AGPAT4/SAMD8/PLPP3/MBOAT7/PLA2G2A/CDS2/LCLAT1/PLA2G6/LYPLA2/DGKG/PLB1	1.25450038140498
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	22/1638	99/9376	1.27201193867861	PTGER4/PLA2G4C/IL1RAP/PLA2G4A/IL1B/CALM2/MAP2K3/HTR2B/PIK3CD/CALM3/PIK3CB/PRKCE/GNAQ/PLA2G6/MAP2K6/CAMK2D/CAMK2G/GNAS/CALML4/PLCB2/TRPV2/ITPR2	1.25178576621258
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	22/1638	100/9376	1.25929181929182	CCL8/CCL2/IL10RA/IL18/CXCR4/CCL3/IL10RB/CXCL3/TNFSF10/CCL5/TNFRSF14/CCL4/CXCL2/TNF/TNFRSF10B/CCL23/IL10/CXCL10/ACKR3/IL20RB/CCL21/IL6	1.19932439929765
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/1638	35/9376	1.47189952904239	AKR1B1/HSD17B14/PFKFB3/GMPPB/GMDS/TIGAR/FPGT/PFKFB2/HK3	1.28681200611599
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	20/1638	90/9376	1.27201193867861	ADIPOR1/CREB1/NFKB1/ATG5/CREB5/SESN1/EIF4EBP1/HRAS/PRKAG2/RHEB/NRAS/EIF4E/RELA/PIK3CD/PIK3CB/PRKAG1/CREB3/ATF6B/FOXO3/CREB3L1	1.19295237198427
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	48/1638	238/9376	1.1544310031705	PDGFC/ETS2/PAK1/RGL1/RASGRP2/RAB5C/PLA2G4C/RASA2/NFKB1/RASA1/IKBKB/TIAM1/MRAS/RALGDS/PLA2G4A/PLD1/HRAS/MAP2K1/CALM2/PDGFB/RAC2/GRB2/RASA3/NRAS/ABL2/RELA/PIK3CD/CALM3/BCL2L1/PIK3CB/GNG7/RASSF5/GNG5/PLA2G2A/EXOC2/PDGFD/PLA2G6/RHOA/CHUK/FGFR1/KDR/HGF/IGF2/CALML4/REL/EFNA4/RASGRF1/BRAP	1.11026236466486
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	22/1638	101/9376	1.24682358345725	WNT6/WNT4/CREB1/HRAS/MAP2K1/CALM2/MITF/NRAS/CALM3/CREB3/GNAQ/FZD3/FZD2/CAMK2D/FZD1/CAMK2G/CREB3L1/WNT2B/GNAS/CALML4/PLCB2/DVL2	1.14740993300979
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	35/1638	170/9376	1.17848164906988	MGST2/TGFBR1/HMOX1/WNT6/WNT4/RB1/CDK6/HRAS/MAP2K1/GRB2/NRAS/PBRM1/DDB2/CDKN2A/PIK3CD/GADD45G/BCL2L1/PIK3CB/TGFB1/TGFB2/MGST1/GADD45B/BRAF/SMARCD1/E2F3/FZD3/FZD2/FZD1/WNT2B/HGF/IGF2/ARID1B/AXIN1/NFE2L2/DVL2	1.0804651652294
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	27/1638	128/9376	1.20741758241758	NUDT2/NUDT16/PDE4B/PDE3B/HPRT1/ADA2/AK2/DCK/RRM1/PGM2/RRM2B/GMPR/PDE7A/ENTPD6/RRM2/LACC1/AK9/CANT1/NME7/ENTPD5/ENTPD3/FHIT/AK5/ADSL/PDE3A/PDE1B/PDE7B	1.08706338153338
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1638	41/9376	1.39611066440335	MMP9/DAPK1/RB1/HRAS/MAP2K1/NRAS/CDKN2A/BRAF/E2F3/THBS1	1.1694442595828
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1638	27/9376	1.48401392845837	TECR/ELOVL1/HACD4/ACOT7/ACOX3/HACD2/ELOVL5	1.1587383637532
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/1638	32/9376	1.43101343101343	GLA/AKR1B1/GALM/GAA/B4GALT1/PGM2/G6PC3/HK3	1.1236410634918
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/1638	37/9376	1.39233739233739	NCOA4/CCDC6/HRAS/MAP2K1/NRAS/DDB2/GADD45G/GADD45B/BRAF	1.10011630069942
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	27/1638	130/9376	1.18884192730347	MMP9/TGFBR1/ARRB2/CREB1/NFKB1/CREB5/GNA15/HRAS/MAP2K1/GRB2/NRAS/MAP2K4/RELA/PIK3CD/PIK3CB/GNG7/TGFB1/CREB3/ATF6B/GNG5/ARRB1/NFKBIA/CREB3L1/FOS/GNAS/PLCB2/JUN	0.99751946722452
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	71/1638	368/9376	1.1043690608908	C9orf72/NDUFS7/NDUFB3/COX8A/ATF6/CYCS/NDUFC1/NDUFS6/DERL1/NDUFB5/ADRM1/NDUFA3/NRBF2/ATP5F1C/PSMA1/ANXA11/UQCR10/DDIT3/NXT1/UQCRFS1/SEC13/CASP1/SLC1A2/PSMA4/TUBB2A/MAP2K3/UQCR11/ATG2B/UQCRQ/NDUFC2/RANBP2/COX7B/TUBA1C/TNF/ANG/PSMD6/BCL2L1/COX6B1/COX6A1/ATXN2L/NUP98/TARDBP/TANK/NUP35/NUP93/NUP37/TUBA1B/COX7A2/UBQLN2/ATP5PF/XBP1/MAP2K6/RAB1A/TUBA3E/TUBB4B/NUP85/PPP3CA/PPP3R1/NUP210/ATG2A/SRSF7/FIG4/NDUFB2/MT-CO2/ALS2/NDUFA13/TUBB/MAP3K5/PFN1/SQSTM1/CASP9	0.939744343993555
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	47/1638	238/9376	1.13038035727111	ISG15/MX1/CCL2/TLR2/IFIH1/STAT1/C3/C3AR1/MX2/IRF9/SYK/EIF2AK2/OAS2/OAS1/FCGR2A/MASP1/TLR7/NFKB1/IKBKB/OAS3/C1QB/TLR4/NFKBIB/TAB2/ADAM17/IL1B/C5AR1/CASP1/TRAF3/MAP3K7/TNF/C1QA/TRAF6/RELA/PIK3CD/NLRP3/PIK3CB/C1QC/NFKBIA/CXCL10/CHUK/FOS/C5/TLR3/RPL36AL/JUN/IL6	0.937353256780039
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	14/1638	63/9376	1.27201193867861	TBXAS1/ALOX5/LTC4S/PLA2G4C/GGT5/PLA2G4A/HPGDS/PTGS1/PTGS2/PLA2G2A/PLA2G6/GPX4/PLB1/CYP2U1	0.996647687072309
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	23/1638	110/9376	1.1968475968476	TGFBR1/ID1/SKIL/SKI/ID3/TGIF1/RBX1/CHRD/TNF/TGIF2/TGFB1/ACVR2A/E2F4/TGFB2/RBL1/ID2/LTBP1/RHOA/FST/SMAD6/THBS1/BAMBI/LEFTY2	0.955451256888345
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1638	38/9376	1.3556969346443	HEXA/GNPDA1/PGM2/GMPPB/UGDH/PGM3/FPGT/HK3/UAP1L1	1.01081856622616
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	30/1638	148/9376	1.16028116028116	WNT6/WNT4/RB1/CDK6/NCOA3/HRAS/MAP2K1/NFKB2/GRB2/NRAS/DDB2/BRCA2/PIK3CD/GADD45G/PIK3CB/NOTCH1/ESR1/GADD45B/BRAF/E2F3/FZD3/FZD2/BRCA1/FGFR1/FZD1/FOS/WNT2B/AXIN1/JUN/DVL2	0.904248436760356
NA	NA	hsa04518	Integrin signaling	31/1638	154/9376	1.15224458081601	PDGFC/C3/ICAM1/ITGB2/ITGA4/ARHGEF6/ITGA6/VTN/LIMS2/ITGA1/NCK2/PARVG/CCND3/PDGFB/RAC2/FERMT3/PARVA/ITGA3/TLN2/PIK3CD/PIK3CB/TGFB1/LAMC3/ICAM2/ITGA9/PDGFD/ICAM4/FERMT2/KDR/HGF/THBS1	0.876431278459768
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	28/1638	138/9376	1.16140220488047	FLOT1/PDE3B/IKBKB/RAPGEF1/EIF4EBP1/HRAS/PHKB/MAP2K1/PTPN1/CALM2/PRKAG2/RHEB/GRB2/NRAS/EIF4E/PIK3CD/CALM3/PIK3CB/PRKAG1/PHKG2/BRAF/GYS1/FLOT2/G6PC3/PRKAR2B/CALML4/HK3/PHKA2	0.878796364658354
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	25/1638	122/9376	1.17296182869953	ADIPOR1/CREB1/RAB11B/CREB5/PPP2R5C/EIF4EBP1/PPP2R2D/PPP2R2A/PRKAG2/RHEB/MAP3K7/PIK3CD/PFKFB3/PIK3CB/PRKAG1/CREB3/STRADA/FOXO3/CCNA2/GYS1/G6PC3/CREB3L1/PFKFB2/CRTC2/PPP2R2B	0.88469517834201
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	13/1638	59/9376	1.26123217648641	HRAS/MAP2K1/GRB2/NRAS/DDB2/PIK3CD/GADD45G/PIK3CB/GADD45B/BRAF/FOXO3/AXIN1/CASP9	0.92606794362482
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1638	75/9376	1.22113146113146	MGST2/PMAIP1/CYCS/ERCC1/BIRC2/CDKN2A/PIK3CD/BCL2L1/PIK3CB/SLC31A1/BIRC5/MGST1/TOP2A/BRCA1/MAP3K5/CASP9	0.884595181263897
Organismal Systems	Nervous system	hsa04730	Long-term depression	13/1638	60/9376	1.24021164021164	GNA13/PLA2G4C/PLA2G4A/LYN/HRAS/MAP2K1/NRAS/RYR1/GNAQ/BRAF/GNAS/PLCB2/ITPR2	0.858782445079074
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	90/1638	480/9376	1.07326007326007	C9orf72/NDUFS7/WNT6/NDUFB3/COX8A/WNT4/SLC25A5/ATF6/CYCS/NDUFC1/NDUFS6/CSNK2B/DERL1/NFKB1/NDUFB5/ADRM1/NDUFA3/NRBF2/ATP5F1C/PSMA1/UQCR10/DDIT3/SNCA/CSNK1E/HRAS/UQCRFS1/IL1B/MAP2K1/CALM2/PSMA4/TUBB2A/MAP2K3/UQCR11/ATG2B/UQCRQ/NDUFC2/NRAS/COX7B/TUBA1C/TNF/RELA/PSMD6/CALM3/BCL2L1/COX6B1/COX6A1/ATXN2L/TARDBP/PTGS2/RYR1/GNAQ/BRAF/IL1A/TANK/TUBA1B/UBE2J2/FZD3/COX7A2/ATP5PF/ATXN1/XBP1/FZD2/MAP2K6/RAB1A/TUBA3E/CAMK2D/TUBB4B/FZD1/CAMK2G/PPP3CA/PPP3R1/ATG2A/WNT2B/LRRK2/FIG4/NDUFB2/MT-CO2/CALML4/ALS2/NDUFA13/TUBB/MAP3K5/PLCB2/AXIN1/UBA7/SQSTM1/DVL2/CASP9/IL6/ITPR2	0.758086572644344
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	28/1638	140/9376	1.14481074481074	KLF2/TGFBR1/MEF2C/GNA13/PDE3B/MRAS/PLIN1/MEF2A/SERPINE1/HRAS/MAP2K1/CALM2/PRKAG2/PIK3CG/NRAS/PIK3R5/CALM3/GNG7/PRKAG1/PRKCE/GNG5/RYR1/GNAQ/SPHK1/CALML4/PLCB2/MYLK3/ITPR2	0.794238741273201
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	36/1638	184/9376	1.11992355470616	SEMA3B/SEMA3A/PAK1/SRGAP1/EPHB2/NCK1/WNT4/CXCR4/UNC5B/NFATC2/PLXNC1/RASA1/SRGAP2/LIMK2/HRAS/SEMA3C/NCK2/RAC2/DPYSL2/NRAS/CFL2/PIK3CD/SEMA4A/SSH2/PIK3CB/SEMA7A/FZD3/RHOA/CAMK2D/CAMK2G/PPP3CA/PPP3R1/SEMA4C/EFNA4/PLXNA4/MYL12A	0.755851746702575
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	31/1638	157/9376	1.13022716844373	TGFBR1/WNT6/WNT4/ID1/NKD1/ITGB2/YWHAH/BIRC2/CSNK1E/SERPINE1/CRB2/PPP2R2D/MOB1B/PPP2R2A/CCND3/FBXW11/BTRC/TGFB1/BIRC5/TGFB2/ID2/FZD3/YWHAQ/FZD2/FZD1/DLG2/WNT2B/AXIN1/PPP2R2B/SCRIB/DVL2	0.757072969870121
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	20/1638	98/9376	1.16817422939872	IPMK/ITPK1/INPP5D/IMPA2/CALM2/PIK3CD/CALM3/MTMR6/IMPA1/PIK3CB/ITPKC/SYNJ1/CDS2/PIP4P1/INPP5B/CALML4/PI4K2B/DGKG/PLCB2/ITPR2	0.76996950366757
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1638	15/9376	1.52641432641433	HEXA/ST6GALNAC3/ST3GAL5/B3GALT4	0.938729424943227
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	16/1638	78/9376	1.17416486647256	LSM5/DHX36/NUDT16/LSM8/PARN/CNOT10/LSM4/BTG2/DCP1A/EXOSC9/CNOT7/CNOT1/PAN3/DIS3L/HSPD1/PAN2	0.71062634790414
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	21/1638	105/9376	1.14481074481074	RAB5C/CITED2/CSNK2B/MRAS/HRAS/OPA1/TBC1D15/MITF/RHOT1/NRAS/RELA/BCL2L1/CCZ1/ATG9B/FOXO3/TBC1D17/FIS1/GABARAP/SQSTM1/HIF1A/JUN	0.686531344764726
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1638	31/9376	1.2925282602702	GRHPR/MDH1/PGP/GLUL/SHMT2/SHMT1/PCCB	0.750563164387442
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/1638	52/9376	1.21085751854983	APOA1/NPC2/STARD3NL/NCEH1/APOC1/SOAT1/NPC1/APOC3/TSPO/APOC2/LRPAP1	0.701484137517501
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	24/1638	122/9376	1.12604335555155	IGFBP3/STAT1/JAK2/CREB1/CREB5/HRAS/MAP2K1/MAP2K3/GRB2/NRAS/MAP2K4/MAP3K1/PIK3CD/PIK3CB/CREB3/ATF6B/GNAQ/MAP2K6/JUNB/CREB3L1/FOS/GNAS/PLCB2/ITPR2	0.644708429350728
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	6/1638	26/9376	1.32093547478163	PLA2G4C/PLA2G4A/PLA2G2A/ACOX3/PLA2G6/PLB1	0.753922696071496
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1638	21/9376	1.36286993429851	CSGALNACT1/DSE/CSGALNACT2/CHPF/CHST11	0.765890992247421
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1638	42/9376	1.22658294086866	HMOX1/NCOA4/ATG5/FTH1/ACSL1/GCLC/ATG7/SAT1/GPX4	0.677089658145085
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1638	37/9376	1.23763323763324	NIT2/GLUL/ASRGL1/RIMKLB/GLUD1/ALDH5A1/GLS/ADSL	0.666324962682861
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1638	37/9376	1.23763323763324	PGM2/GMPPB/GMDS/UGDH/PGM3/FPGT/HK3/UAP1L1	0.666324962682861
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/1638	53/9376	1.1880111502753	ATP1A1/AP2A2/CLTB/ATP1B3/ESR1/AP2S1/GNAQ/ATP2B1/ATP2B3/GNAS/PLCB2	0.631497918502982
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	14/1638	70/9376	1.14481074481074	NFKBIE/ADIPOR1/JAK2/NFKB1/IKBKB/NFKBIB/ACSL1/PRKAG2/TNF/RELA/PRKAG1/NFKBIA/CHUK/G6PC3	0.559495383449527
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1638	22/9376	1.3009213009213	MAOA/ALDH2/HNMT/ALDH3B1/MAOB	0.650120427861155
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1638	38/9376	1.20506394190605	SGK1/ATP1A1/ATP1B3/PIK3CD/PIK3CB/NEDD4L/NR3C2/HSD11B2	0.582750143600305
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	13/1638	65/9376	1.14481074481074	GLA/AKR1B1/PLPP5/AKR1A1/ALDH2/AGPAT1/AGPAT3/PNPLA2/AGPAT4/PLPP3/LCLAT1/DGKG/GK	0.538998462657139
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1638	65/9376	1.14481074481074	NR4A1/NCEH1/CREB1/CREB5/CREB3/ATF6B/ORAI1/GNAQ/CREB3L1/GNAS/PLCB2/KCNA4/ITPR2	0.538998462657139
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	55/1638	298/9376	1.05645286853341	PRL/IL1RL1/CCL8/CCL2/TGFBR1/TNFSF13B/CSF2RA/IL10RA/IL1R2/IL18/EDA/CXCR4/IL17RA/CCL3/IL13RA1/IL10RB/TNFSF12/TNFRSF21/IL1RAP/CXCL3/TNFSF13/TNFSF8/CXCL16/IL1B/TNFSF10/CD4/CCL5/TNFRSF14/CCL4/IFNGR2/CXCL2/TNF/INHA/EBI3/TNFRSF10B/TGFB1/ACVR2A/CCL23/TGFB2/TNFRSF18/IL1A/OSM/IL10/PRLR/CXCL10/ACKR3/IL20RB/CLCF1/CCL21/CSF2RB/IL1RN/IL3RA/IL16/IL23A/IL6	0.455645705780869
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1638	12/9376	1.43101343101343	NPC1/FCGR2B/ASGR1	0.687351600653823
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	14/1638	71/9376	1.12868664981341	HRAS/MAP2K1/IDH1/IDH2/NRAS/PIK3CD/PIK3CB/PDHB/SLC7A5/TIGAR/FGFR1/GLS/HK3/HIF1A	0.500763544268994
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/1638	44/9376	1.17082917082917	RAB5C/ARHGDIB/CREB1/VAMP2/RAB11B/CREB5/CREB3/CREB3L1/GNAS	0.522551658321911
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1638	28/9376	1.22658294086866	B4GALT1/B3GNT2/B3GNT5/ST3GAL6/ST3GAL3/GCNT2	0.552427255239337
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	6/1638	28/9376	1.22658294086866	ATP6V1B2/ATP6V1E1/ATP6V0A1/ATP6V0C/ATP6V1F/SLC12A7	0.552427255239337
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/1638	110/9376	1.09277389277389	HMOX1/NFKB1/TLR4/EGLN2/EIF4EBP1/SERPINE1/RBX1/MAP2K1/ELOC/IFNGR2/EIF4E/RELA/PIK3CD/PFKFB3/PIK3CB/PDHB/CAMK2D/CAMK2G/HK3/HIF1A/IL6	0.450302334784752
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1638	50/9376	1.14481074481074	SMS/MAOA/SMOX/ALDH2/ARG1/LAP3/MAOB/ARG2/CKB/SAT1	0.47235259769742
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1638	23/9376	1.24435950522907	GLUL/ARG1/GLUD1/ARG2/GLS	0.539816198116708
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1638	23/9376	1.24435950522907	ATP1A1/MDH1/ATP1B3/GLUD1/GLS	0.539816198116708
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	15/1638	78/9376	1.10077956231802	IPMK/ITPK1/INPP5D/IMPA2/PIK3CG/PIK3CD/MTMR6/IMPA1/PIK3CB/ITPKC/SYNJ1/INPP5B/FIG4/PI4K2B/PLCB2	0.411200110354741
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/1638	56/9376	1.12436769579627	GRK3/ARRB2/GRK2/DISP1/CSNK1E/FBXW11/BTRC/SPOPL/GAS1/SUFU/ARRB1	0.429459159321022
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/1638	134/9376	1.06792047090555	GNA13/PLA2G4C/PLA2G4A/ARHGEF11/MAP2K1/CALM2/KCNMA1/KCNMB1/ADM/CALM3/MYH10/PPP1R12B/PRKCE/GNAQ/PLA2G2A/BRAF/PLA2G6/RHOA/KCNMB4/RAMP3/GNAS/CALML4/PLCB2/MYLK3/ITPR2	0.364332848757522
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/1638	62/9376	1.10788136594588	MAML3/PSENEN/ADAM17/NCSTN/LFNG/DTX3L/NOTCH1/MAML1/ATXN1/MAML2/KAT2A/DVL2	0.39210500768054
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	15/1638	79/9376	1.08684564380767	SLC1A3/NAPA/ATP6V1B2/ATP6V0B/ATP6V1E1/VAMP2/ATP6V0A1/ATP6V0C/AP2A2/ATP6V1F/SLC1A2/CLTB/AP2S1/SYT1/STX3	0.356630426890129
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/1638	57/9376	1.10464194674721	TECR/ELOVL1/HACD4/PPT1/ACSL1/ACSF3/HADH/ACOX3/HACD2/ELOVL5/MECR	0.364574934811008
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1638	24/9376	1.19251119251119	EXT2/GLCE/HS2ST1/NDST2/HS3ST1	0.434447777907446
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1638	46/9376	1.11992355470616	HMOX1/BLVRA/FTH1/BLVRB/HCCS/ALAS1/FXN/ALAD/PPOX	0.375120510991073
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/1638	63/9376	1.0902959474388	WNT6/WNT4/DDB2/GADD45G/SUFU/GADD45B/FZD3/FZD2/FZD1/WNT2B/AXIN1/DVL2	0.33084300492126
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1638	41/9376	1.11688853152268	MAOA/GRHPR/SHMT2/ALAS1/MAOB/SHMT1/SDS/SRR	0.345092002019583
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1638	19/9376	1.20506394190605	IDS/ARSB/HEXA/HPSE	0.411648001624108
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/1638	86/9376	1.06494022773093	PAK1/NCK1/EIF4EBP1/HRAS/MAP2K1/NCK2/GRB2/NRAS/MAP2K4/ABL2/PIK3CD/PIK3CB/BRAF/CAMK2D/CAMK2G/JUN	0.278344984469666
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	16/1638	86/9376	1.06494022773093	ATP1A1/CREB1/VAMP2/CREB5/KCNMA1/ATP1B3/KCNMB1/CREB3/ATF6B/GNAQ/KCNMB4/CAMK2D/CAMK2G/CREB3L1/GNAS/PLCB2	0.278344984469666
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	28/1638	154/9376	1.04073704073704	ATP1A1/CREB1/CREB5/SCN1B/PPP2R5C/CREM/PPP2R2D/CALM2/PPP2R2A/ATP1B3/PIK3CG/PIK3R5/CALM3/CACNA2D3/CREB3/ATF6B/GNAQ/ATP2B1/ADRB2/ATP2B3/CAMK2D/CAMK2G/CREB3L1/GNAS/CALML4/CACNB4/PLCB2/PPP2R2B	0.234512233555165
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1638	36/9376	1.11301044634378	C1GALT1/ST6GALNAC3/GALNT1/GALNT2/GALNT7/GALNT10/GALNT18	0.312553687234755
Cellular Processes	Cell motility	hsa04814	Motor proteins	35/1638	194/9376	1.03269010485505	TUBG1/MYO5A/KIF20B/MYO1F/DYNLRB1/KIF11/DYNLT3/KIF22/KIF2C/KIF16B/DYNLT1/TUBB2A/MYO9B/KIF23/KIF4A/TUBA1C/KIF18A/KIF13B/MYH10/CENPE/KIF14/KIF15/KIF18B/TUBA1B/KIFC1/MYO19/KIF1B/TUBA3E/MYO18A/TUBB4B/KIF26B/KIFC3/MYO15B/TUBB/MYL12A	0.211678504495493
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	55/1638	308/9376	1.02215245072388	SLC1A3/NDUFS7/NDUFB3/POLR2K/POLR2J/COX8A/POLR2I/SLC25A5/CYCS/NDUFC1/CREB1/NDUFS6/CREB5/NDUFB5/POLR2J3/ADRM1/NDUFA3/NRBF2/ATP5F1C/PSMA1/UQCR10/POLR2F/UQCRFS1/AP2A2/SLC1A2/PSMA4/CLTB/TUBB2A/UQCR11/ATG2B/UQCRQ/NDUFC2/COX7B/TUBA1C/PSMD6/COX6B1/COX6A1/CREB3/AP2S1/GNAQ/TUBA1B/COX7A2/ATP5PF/TUBA3E/TUBB4B/ATG2A/CREB3L1/NDUFB2/MT-CO2/TAF4/NDUFA13/TUBB/MAP3K5/PLCB2/CASP9	0.181873575974386
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1638	14/9376	1.22658294086866	B4GALT1/B3GNT2/ST3GAL3	0.390332877302464
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	35/1638	195/9376	1.02739425816349	TLR2/C3/FPR3/HAT1/SYK/NCF4/CLEC7A/SELPLG/FPR1/SLC25A5/FCGR2A/TLR7/NFKB1/ITGB2/NCF1/TLR4/CAMP/GSDMD/FCGR3A/HDAC9/C5AR1/MAP2K1/CASP1/RAC2/MAP3K7/CASP4/RELA/PIK3CD/PIK3CB/ATG7/CLCN5/CYBA/C5/PLCB2/CR1L	0.177852543480948
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	32/1638	178/9376	1.02904336612202	LGR4/WNT6/WNT4/CSNK2B/NFATC2/NKD1/DAAM1/CTNNBIP1/CSNK1E/RBX1/CCND3/NLK/RAC2/FBXW11/BTRC/MAP3K7/NFATC1/PPARD/FZD3/FZD2/RHOA/CAMK2D/FZD1/CAMK2G/PPP3CA/PPP3R1/WNT2B/PLCB2/BAMBI/AXIN1/JUN/DVL2	0.179985895164647
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	26/1638	144/9376	1.03350970017637	KLF4/WNT6/WNT4/ID1/JAK2/SKIL/RIF1/ID3/HRAS/MAP2K1/GRB2/NRAS/ZFHX3/PIK3CD/PIK3CB/ACVR2A/ID2/FZD3/FZD2/FGFR1/FZD1/WNT2B/HESX1/AXIN1/LEFTY2/DVL2	0.186437003621165
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/1638	93/9376	1.04633240117111	ATP1A1/VAMP2/CAMP/CALM2/KCNMA1/ATP1B3/BST1/CALM3/GNAQ/ATP2B1/ADRB2/ATP2B3/GNAS/CALML4/PLCB2/AMY2B/ITPR2	0.206590492659849
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	21/1638	116/9376	1.03625110521662	MMP9/NCF4/CXCR4/ICAM1/ITGB2/NCF1/ITGA4/THY1/VAV1/CLDN4/RAC2/CLDN20/PIK3CD/PIK3CB/F11R/RASSF5/CYBA/RHOA/CLDN10/CLDN1/MYL12A	0.180747782258119
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/1638	99/9376	1.04073704073704	MMP9/CDKN2C/RB1/NCOA3/HRAS/MAP2K1/GRB2/NRAS/CDKN2A/PIK3CD/PIK3CB/NOTCH1/ESR1/BRAF/E2F3/FOS/GNAS/JUN	0.18746988827024
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1638	54/9376	1.06000994889884	SMS/MDH1/ENOPH1/GCLC/MAT2B/LACC1/BCAT2/AHCYL2/DNMT3B/SDS	0.203466920382878
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	30/1638	168/9376	1.02215245072388	PRL/CSF2RA/STAT1/IRF9/IL10RA/JAK2/IL13RA1/IL10RB/HRAS/PTPN2/PIAS1/CCND3/PDGFB/GRB2/CISH/IFNGR2/PTPN6/PIK3CD/SOCS6/BCL2L1/PIK3CB/OSM/IL10/PRLR/IL20RB/CLCF1/CSF2RB/IL3RA/IL23A/IL6	0.133297495295742
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	45/1638	254/9376	1.01410400622999	PDGFC/CAMK1D/SLC25A5/CXCR4/P2RX4/NFATC2/GNA15/P2RX7/PHKB/CALM2/CAMK1/MCOLN1/PDGFB/HTR2B/ORAI2/NFATC1/CYSLTR1/CALM3/PHKG2/STIM2/ORAI1/ITPKC/RYR1/GNAQ/ATP2B1/PDGFD/ADRB2/ATP2B3/CAMK2D/FGFR1/SPHK1/CAMK2G/PPP3CA/PPP3R1/KDR/HGF/CYSLTR2/GNAS/CALML4/PLCB2/MYLK3/PHKA2/GNAL/PDE1B/ITPR2	0.104843748435358
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1638	26/9376	1.10077956231802	APOA1/ABCC1/TCN2/PLB1/SLC46A1	0.236745406170534
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1638	83/9376	1.03446754049164	AGPS/PMVK/ACSL1/IDH1/IDH2/PEX16/PEX11B/PEX1/ACOX3/PEX10/PEX11A/NUDT19/PXMP4/MPV17L2/PXMP2	0.145110753188513
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	36/1638	203/9376	1.01510312347751	PDGFC/PAK1/ITGA4/ITGA6/VTN/RAPGEF1/BIRC2/HRAS/ITGA1/MAP2K1/VAV1/PARVG/CCND3/PDGFB/RAC2/GRB2/PARVA/ITGA3/DIAPH1/TLN2/PIK3CD/PIK3CB/PPP1R12B/BRAF/EMP2/LAMC3/ITGA9/PDGFD/RHOA/KDR/HGF/THBS1/RASGRF1/MYLK3/MYL12A/JUN	0.100089223382242
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/1638	32/9376	1.07326007326007	PMAIP1/CYCS/BIRC2/BCL2L1/BIRC5/CASP9	0.190987149602006
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1638	15/9376	1.14481074481074	TPK1/AK2/AK5	0.258234057054894
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/1638	38/9376	1.05443094916779	CIITA/BLNK/PTPRC/CD4/UNG/ORAI1/RFX5	0.154681720974446
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/1638	62/9376	1.01555791878373	HSPA1B/HSPA1A/ATG5/HRAS/PRKAG2/NRAS/PIK3CD/PIK3CB/PRKAG1/HSPA6/FOXO3	0.0565467243642986
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1638	10/9376	1.14481074481074	SQOR/ETHE1	0.210790937195872
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1638	51/9376	1.01012712777419	ATP6AP1/ATP6V1B2/ATP6V0B/ATP6V1E1/ATP6V0A1/ATP6V0C/ATP6V1F/SEC61G/GNAS	0.033363774832909
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	20/1638	115/9376	0.995487604183256	JAK2/CREB1/CREB5/HRAS/MAP2K1/PIK3CG/NRAS/PIK3R5/PIK3CD/PIK3CB/GNG7/CREB3/GNG5/GNAQ/CAMK2D/CAMK2G/CREB3L1/FOS/PLCB2/ITPR2	-0.0224003802302641
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	20/1638	115/9376	0.995487604183256	ALOX5/MAOA/PLA2G4C/DUSP1/PLA2G4A/HRAS/MAP2K1/PTGS1/HTR2B/NRAS/GNG7/KCND2/GNG5/PTGS2/GNAQ/BRAF/MAOB/GNAS/PLCB2/ITPR2	-0.0224003802302641
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1638	16/9376	1.07326007326007	MAOA/ALDH3B1/MAOB	0.134932833328765
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1638	16/9376	1.07326007326007	GLA/HEXA/NAGA	0.134932833328765
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/1638	87/9376	0.986905814492021	COX8A/ATP1A1/UQCR10/UQCRFS1/UQCR11/ATP1B3/UQCRQ/COX7B/CACNA2D3/COX6B1/COX6A1/COX7A2/MT-CO2/SLC9A6/CACNB4	-0.0564523282918693
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1638	23/9376	0.995487604183256	PMVK/PDSS2/IDI1/PDSS1	-0.00996836342383668
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1638	17/9376	1.01012712777419	PCDH20/NRP2/MYH10	0.0192275633440843
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1638	59/9376	0.970178597297241	PDE3B/PLIN1/PNPLA2/PTGS1/PIK3CD/PIK3CB/PTGS2/ABHD5/ADRB2/GNAS	-0.105716858651934
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/1638	48/9376	0.954008954008954	ATP1A1/ATP1B3/PIK3CD/PIK3CB/G6PC3/PLCB2/HK3/AMY2B	-0.146969718113148
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1638	36/9376	0.954008954008954	GAA/PGM2/GYS1/G6PC3/HK3/AMY2B	-0.12719771905472
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	24/1638	143/9376	0.96068034529573	HLA-DMA/HLA-DQA1/C3/HLA-DMB/HLA-DPA1/CD86/SNRPD3/FCGR2A/HLA-DRA/HLA-DRB1/C1QB/SNRPD1/FCGR3A/HLA-DQA2/HLA-DPB1/SNRPB/HLA-DOA/TNF/C1QA/HLA-DQB1/C1QC/IL10/TRIM21/C5	-0.217988970570916
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/1638	30/9376	0.954008954008954	MDH1/OGDH/IDH1/IDH2/PDHB	-0.116077821871385
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	5/1638	30/9376	0.954008954008954	PLA2G4C/PLA2G4A/PLA2G2A/PLA2G6/PLB1	-0.116077821871385
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	38/1638	226/9376	0.962451511124078	PAK1/ATP1A1/PDE4B/PDE3B/CREB1/FXYD1/NFKB1/CREB5/TIAM1/PLD1/MAP2K1/CALM2/VAV1/ATP1B3/RAC2/NFATC1/RELA/PIK3CD/CALM3/PIK3CB/CREB3/ORAI1/BRAF/ATP2B1/ADRB2/ACOX3/NFKBIA/RHOA/ATP2B3/CAMK2D/CAMK2G/CREB3L1/FOS/GNAS/CALML4/PDE3A/JUN/HCAR3	-0.262884124783494
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1638	18/9376	0.954008954008954	ACSL1/ACSF3/MECR	-0.0898558265278212
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1638	18/9376	0.954008954008954	CD320/TCN2/THAP11	-0.0898558265278212
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	16/1638	97/9376	0.944173810153192	PER3/PER1/CREB1/CALM2/CALM3/GNG7/NOS1AP/GNG5/RYR1/GNAQ/CAMK2D/CAMK2G/FOS/GNAS/CALML4/PLCB2	-0.254273728991381
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	17/1638	103/9376	0.944746731154498	CPSF6/MAGOH/UPF3B/PPP2R5C/NXT1/PPP2R2D/PPP2R2A/UPF1/PELO/ETF1/PABPN1/EIF4A3/SMG7/SYMPK/TARDBP/CPSF1/PPP2R2B	-0.259414760305899
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1638	31/9376	0.923234471621568	RBKS/PGD/PGM2/H6PD/IDNK	-0.196963458649673
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1638	31/9376	0.923234471621568	SMOX/ALDH2/DPYD/ALDH3B1/ACOX3	-0.196963458649673
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	19/1638	116/9376	0.93756052376742	SLC1A3/GRK3/PLA2G4C/GRK2/PLA2G4A/PLD1/SLC1A2/GLUL/GNG7/GNG5/GNAQ/HOMER2/PPP3CA/PPP3R1/GLS/GRM7/GNAS/PLCB2/ITPR2	-0.311322835178619
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/1638	122/9376	0.938369462959627	TBC1D4/STAT1/WNT4/ATP1A1/NCOA3/NCOA2/HRAS/MAP2K1/ATP1B3/RHEB/NRAS/PIK3CD/PIK3CB/NOTCH1/ESR1/PFKFB2/PLCB2/KAT2A/HIF1A/CASP9	-0.315238566614402
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1638	38/9376	0.903797956429535	NAMPT/NMRK1/NADK/BST1/NADSYN1/SIRT2	-0.273386701651412
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	16/1638	99/9376	0.925099591766258	SGCE/ITGA4/ITGA6/ITGA1/PRKAG2/ITGA3/TNF/CACNA2D3/TGFB1/PRKAG1/TGFB2/ITGA9/DMD/CACNB4/LMNA/IL6	-0.344688050700929
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/1638	93/9376	0.923234471621568	TGFBR1/CSNK2B/WAS/NECTIN2/LMO7/PTPN1/NLK/RAC2/MAP3K7/PTPN6/IQGAP1/RHOA/FGFR1/BAIAP2/MYL12A	-0.342288073273487
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1638	75/9376	0.915848595848596	ATP1A1/CREB1/CREB5/ATP1B3/CREB3/ATF6B/GNAQ/CREB3L1/GNAS/PLCB2/ASGR1/ITPR2	-0.336632002646918
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1638	13/9376	0.880623649854419	XRCC4/MRE11	-0.198157577891804
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/1638	82/9376	0.907471931862176	MGST2/HPRT1/UPP1/CDA/RRM1/TK1/RRM2B/DPYD/RRM2/MGST1/TK2/NME7/NAT1	-0.387175003647505
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1638	76/9376	0.903797956429535	ATP1A1/CALM2/ATP1B3/CALM3/GNAQ/CAMK2D/CAMK2G/GNAS/CALML4/PLCB2/MYLK3/ITPR2	-0.387416259510462
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1638	33/9376	0.867280867280867	OGDH/IDH1/IDH2/PDHB/BCAT2	-0.351378799544013
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	24/1638	150/9376	0.915848595848596	TGFBR1/WNT6/WNT4/RB1/HRAS/MAP2K1/GRB2/NRAS/DDB2/PIK3CD/GADD45G/PIK3CB/TGFB1/TGFB2/GADD45B/BRAF/E2F3/FZD3/FZD2/FZD1/WNT2B/HGF/AXIN1/DVL2	-0.478000659297332
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1638	65/9376	0.880623649854419	ARRB2/HRAS/MAP2K1/NRAS/PIK3CD/PIK3CB/GNAQ/ARRB1/PLCB2/ITPR2	-0.444329385158402
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	35/1638	217/9376	0.923234471621568	AHR/MGST2/KLF4/ARRB2/JAK2/CREB1/NFKB1/CREB5/HSP90AA1/RB1/EIF4EBP1/HRAS/BCL6/MAP2K1/CCND3/GRB2/NRAS/RPS6KA3/RELA/PIK3CD/PIK3CB/KPNA2/RPS6KA1/CREB3/BIRC5/ATF6B/ESR1/MGST1/ARRB1/ADRB2/CREB3L1/FOS/GNAS/PAQR8/JUN	-0.526381121636678
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1638	21/9376	0.817721960579103	ALDH2/DPYD/BCAT2	-0.384724925604176
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1638	47/9376	0.852518639752682	GRHPR/MDH1/AKR1A1/ALDH2/HAGH/ME1/PDHB	-0.466333635499942
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1638	91/9376	0.880623649854419	GRK3/PDE4B/PDE3B/ARRB2/GRK2/GRK5/PDE7A/GNG7/GNG5/ARRB1/GNAS/PDE3A/PDE1B/PDE7B	-0.526473193220792
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	18/1638	116/9376	0.888215233042819	ADPGK/PGD/MDH1/OGDH/PGP/ME1/IDH1/IDH2/H6PD/SHMT2/PDHB/GLUD1/SHMT1/ACOX3/IDNK/PCCB/HK3/SDS	-0.557358143896988
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1638	48/9376	0.834757834757835	ALDH2/MCCC2/ACSF3/HADH/BCAT2/PCCB/AACS	-0.528050491627769
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1638	48/9376	0.834757834757835	CHMP1B/CLDN4/CLDN20/CHMP1A/CD9/CLDN10/CLDN1	-0.528050491627769
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	18/1638	117/9376	0.880623649854419	POLE3/CDK2AP2/EPC2/BRD8/PBRM1/BAZ1A/TFPT/YEATS4/ING3/BAZ2A/MCRS1/BAZ2B/SMARCD1/DMAP1/NFRKB/VPS72/ARID1B/INO80C	-0.597802063117521
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/1638	61/9376	0.844532516663664	HMOX1/ATP1A1/FTH1/SLC39A4/ATP1B3/SLC31A1/ATP2B1/ATP2B3/SLC46A1	-0.560455687179927
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1638	42/9376	0.817721960579103	MAOA/ALDH2/KYNU/KMO/HADH/MAOB	-0.544694913596315
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1638	29/9376	0.789524651593617	PAK1/CSNK1E/MOB1B/RASSF2	-0.522266703658882
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1638	36/9376	0.795007461674128	AKR1B1/AKR1A1/DCXR/CRYL1/UGDH	-0.566949125344194
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1638	43/9376	0.798705170798194	ECI1/ALDH2/ACSL1/HADH/ACOX3/CYP2U1	-0.60867356159846
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	22/1638	144/9376	0.874508207841541	SLC25A5/CYCS/PUM2/ADRM1/NRBF2/PSMA1/OPA1/PSMA4/GTF2B/ATG2B/PIK3CD/PSMD6/PIK3CB/ATXN2L/RYR1/GNAQ/ATXN1/XBP1/ATG2A/MAP3K5/PLCB2/ITPR2	-0.698195256476021
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1638	37/9376	0.773520773520774	MAOA/COMT/FAH/ALDH3B1/MAOB	-0.63504905136682
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	15/1638	102/9376	0.841772606478489	ATP1A1/CPB1/KCNMA1/ATP1B3/BST1/CPA1/GNAQ/PLA2G2A/ATP2B1/RHOA/ATP2B3/GNAS/PLCB2/AMY2B/ITPR2	-0.739224646602715
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1638	31/9376	0.738587577297255	HSD17B14/AKR1A1/ALDH2/UGDH	-0.670726770168231
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1638	17/9376	0.673418085182791	GGT5/ADO	-0.620054826422349
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1638	17/9376	0.673418085182791	GLUL/GLUD1	-0.620054826422349
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/1638	66/9376	0.780552780552781	COMT/SRD5A3/HSD17B11/CYP3A5/HSD11B1/HSD17B6/DHRS9/RDH5/HSD11B2	-0.823105367778514
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/1638	67/9376	0.768902739051993	ADPGK/GALM/AKR1A1/ALDH2/PGM2/PDHB/ALDH3B1/G6PC3/HK3	-0.873391394479675
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1638	47/9376	0.730730262645156	IKBKB/TNF/PIK3CD/PIK3CB/PRKCE/HK3	-0.851426480880201
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/1638	75/9376	0.763207163207163	IDH1/GLUL/IDH2/ARG1/SHMT2/MAT2B/ARG2/SHMT1/BCAT2/SDS	-0.947245594602325
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1638	19/9376	0.602531970953024	OGDH/PDHB	-0.797882447522755
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1638	27/9376	0.636005969339303	ALDH5A1/HADH/AACS	-0.871408491997523
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1638	76/9376	0.753164963691279	APOA1/OLR1/PLIN1/ACSL1/ME1/APOC3/PPARD/ACOX3/GK/SLC27A6	-0.994031965784692
Genetic Information Processing	Transcription	hsa03040	Spliceosome	36/1638	243/9376	0.84800795911907	LSM5/HSPA1B/HSPA1A/SNRPD3/DDX46/PRPF38B/LSM8/PUF60/MAGOH/TRA2B/LSM4/BCAS2/SNRPG/SNRPD1/SNU13/PRPF8/SNRPB/RP9/PRPF40A/YJU2/PRPF19/THOC1/EIF4A3/HSPA6/U2AF2/PRPF3/DHX38/THOC6/THOC3/RBMXL1/SRSF7/U2AF1/U2AF1L4/HNRNPU/PRPF40B/SF3A2	-1.10444852300568
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/1638	105/9376	0.763207163207163	SGCE/ITGA4/ITGA6/ITGA1/ITGA3/TNF/CACNA2D3/TGFB1/TGFB2/ITGA9/DMD/GNAS/CACNB4/LMNA	-1.12260802806104
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1638	12/9376	0.477004477004477	COQ3	-0.834038533371259
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1638	29/9376	0.592143488695213	CALM2/CALM3/CALML4	-1.01204192005273
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1638	86/9376	0.732146406565011	SGCE/ITGA4/ITGA6/ITGA1/ITGA3/CACNA2D3/ITGA9/DSC2/DMD/CACNB4/LMNA	-1.1480665669009
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/1638	89/9376	0.707467314208887	ITGA4/ITGA6/VTN/ITGA1/ITGA3/HMMR/LAMC3/GP6/ITGA9/THBS1/SDC1	-1.27573333339541
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	33/1638	233/9376	0.810702887956107	FBN2/FMNL2/SUN2/ATP1A1/SGCE/NID2/FMNL3/ITGA4/CSRP1/ITGA6/SYNE1/DAAM1/ITGA1/ATP1B3/ITGA3/DIAPH1/TLN2/MYH10/LBR/DIAPH3/FMNL1/LMNB1/PDLIM7/ITGA9/DSC2/SYNE3/DMD/NEB/TMOD2/THBS1/COL24A1/LMNA/SDC1	-1.34618830459274
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1638	23/9376	0.497743802091628	B4GALT1/ST3GAL3	-1.10953748650493
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/1638	63/9376	0.636005969339303	ALDH2/NSD2/SMYD3/KMT2E/HADH/EZH2/SETD1B	-1.33366870045636
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/1638	78/9376	0.660467737390814	RHOG/HCLS1/ELMO1/ARPC1B/CLTB/PIK3CD/PIK3CB/ARPC3/RHOA	-1.38535731494165
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1638	43/9376	0.532470113865463	APOA1/AGPAT1/PLPP3/PLA2G2A	-1.41371282151483
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/1638	103/9376	0.666880045520822	ATP1A1/CPB1/COL14A1/PRCP/ATP1B3/SLC7A8/SLC36A4/CPA1/MME/COL26A1/COL24A1/COL23A1	-1.56400218394251
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1638	17/9376	0.336709042591396	CYP39A1	-1.25933721618878
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1638	17/9376	0.336709042591396	SEPHS1	-1.25933721618878
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/1638	52/9376	0.550389781159012	ALOX5/PLA2G4C/PLA2G4A/PTGS2/GNAS	-1.49577040814979
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7/1638	68/9376	0.589240824534942	CYP3A5/DHRS4L2/DHRS3/HSD17B6/RDH13/DHRS9/RDH5	-1.56401807095993
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1638	45/9376	0.508804775471442	ABCC3/ABCB8/ABCC1/ABCG1	-1.51958333567903
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1638	46/9376	0.497743802091628	ADRM1/PSMA1/PSMA4/PSMD6	-1.57105584527957
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1638	70/9376	0.572405372405372	MGST2/CYP3A5/HPGDS/HSD11B1/MGST1/PTGS2/NAT1	-1.65206815585181
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	18/1638	149/9376	0.691496423040047	NDUFS7/NDUFB3/NDUFC1/NDUFS6/NDUFB5/NDUFA3/CNR1/DAGLB/NDUFC2/GNG7/GNG5/PTGS2/GNAQ/NDUFB2/NDUFA13/PLCB2/DAGLA/ITPR2	-1.74643047827342
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1638	73/9376	0.548881863950357	MGST2/MAOA/CYP3A5/HPGDS/MGST1/ALDH3B1/MAOB	-1.78019850075681
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/1638	32/9376	0.357753357753358	ACOX3/PCCB	-1.67432067817759
Human Diseases	Substance dependence	hsa05034	Alcoholism	22/1638	191/9376	0.65931508863446	FOSB/HAT1/MAOA/CREB1/CREB5/HRAS/HDAC9/MAP2K1/CALM2/SLC29A1/GRB2/NRAS/CALM3/GNG7/CREB3/ATF6B/GNG5/BRAF/MAOB/CREB3L1/GNAS/CALML4	-2.18855883881554
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1638	26/9376	0.220155912463605	HHEX	-1.83196375343331
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	40/1638	323/9376	0.708861142297675	MMP9/HMOX1/PLAU/FOXP1/NFKB1/IKBKB/STMN1/CDK6/ABCC1/CDC25B/HRAS/MAP2K1/PDGFB/GRB2/KIF23/NRAS/MDM4/CDKN2A/PIK3CD/CDCA5/PIK3CB/RDX/NOTCH1/PRKCE/TGFB2/PTGS2/EZH2/E2F3/FZD3/CDC25C/MAPK7/RHOA/BRCA1/ZEB2/GLS/BMF/EFNA4/THBS1/DNMT3B/SLC7A1	-2.44981561730546
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1638	79/9376	0.434738257523068	MGST2/CYP3A5/HPGDS/HSD11B1/MGST1/ALDH3B1	-2.32123947368797
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/1638	89/9376	0.450206472678383	GLUL/GNG7/GNG5/TRAK2/GABARAP/GLS/SLC12A5	-2.39764636007228
NA	NA	hsa04382	Cornified envelope formation	22/1638	217/9376	0.580318810733557	SPTLC1/KRT23/ELOVL1/PPP2R5C/ITGA6/PPP2R2D/PPP2R2A/CLDN4/CLDN20/KDSR/TCHH/KRT81/ABHD5/S100A11/SPTLC3/S100A2/CLDN10/KRT18/S100A1/CLDN1/PPP2R2B/GBA2	-2.87775333280913
NA	NA	hsa04519	Cadherin signaling	48/1638	404/9376	0.68008559097668	WNT6/KRT23/WNT4/PSENEN/NFKB1/TAOK3/IKBKB/SCN1B/LHFPL2/MRAS/MYO1F/YWHAH/NCKAP1L/PCDH20/DAAM1/FMN1/NCSTN/HRAS/ARPC1B/MAP2K1/MOB1B/VAV1/RERE/MAP2K3/RAC2/NRAS/RELA/MPDZ/KRT81/ARPC3/DSC2/FZD3/NFKBIA/YWHAQ/FZD2/RHOA/CHUK/PCDHB16/FGFR1/FZD1/KRT18/KDR/WNT2B/AXIN1/ERBIN/PCDHB4/DVL2/CDH3	-3.0241830545241
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/1638	90/9376	0.318002984669651	NCEH1/ATP1A1/ABCC3/ATP1B3/GNAS	-2.99100826631666
NA	NA	hsa04082	Neuroactive ligand signaling	17/1638	199/9376	0.488989514115142	SLC1A3/P2RY13/P2RX4/SLC1A2/HTR2B/ADORA3/GNG7/GNG5/GNAQ/ADRB2/GRM7/P2RY11/GNAS/P2RY6/PLCB2/P2RY12/GNAL	-3.35223308829123
Genetic Information Processing	Translation	hsa03010	Ribosome	19/1638	222/9376	0.48989648989649	MRPL33/MRPS15/MRPL4/MRPS2/MRPL48/MRPL54/MRPL32/MRPL41/MRPS18A/MRPL38/MRPS18B/MRPS6/MRPL24/MRPS12/MRPL40/MRPS17/MRPS22/RPL36AL/MRPL53	-3.5388126364671
NA	NA	hsa04081	Hormone signaling	18/1638	219/9376	0.470470169100306	PRL/GNA13/ADIPOR1/JAK2/GNA15/PIK3CD/PIK3CB/GNG7/ESR1/GNG5/GNAQ/PRLR/ADRB2/RHOA/RAMP3/GNAS/IGF2/PLCB2	-3.64807791655116
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	13/1638	183/9376	0.406626767282505	TCOF1/CSNK2B/GNL2/RRP7A/POP5/POP4/NOP10/SNU13/NXT1/RIOK1/RCL1/EFL1/UTP15	-3.72952128655264
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1638	86/9376	0.133117528466366	PLCB2/PDE1B	-3.71560735936792
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	32/1638	370/9376	0.495053295053295	PRL/P2RY13/PTGER4/C3/C3AR1/FPR3/FPR1/LPAR6/P2RX4/GAL/NR3C1/CNR1/P2RX7/C5AR1/HTR2B/CYSLTR1/ADM/ADORA3/TMEM97/PRLR/ADRB2/NPW/TSPO/LYNX1/UTS2/P2RY8/GRM7/CYSLTR2/P2RY11/LYPD6/C5/P2RY6	-4.55941010559002
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	12/1638	449/9376	0.152981391288741	GRK3/ARRB2/GRK2/CALM2/CALM3/GNG7/ARRB1/CAMK2D/CAMK2G/CALML4/GNAL/PDE1B	-8.46236160210953