category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	105/2062	158/9376	3.02176822305983	CUL1/CDK6/CCND3/TFDP1/PDS5A/CDKN2A/BUB1/KNL1/WEE1/TGFB1/GSK3B/BUB3/PCNA/PPP2R5A/EP300/CCNH/MCM3/SMC1A/DBF4/MAD2L1/CDC27/E2F3/ORC6/FZR1/PTTG1/RAD21/CCND2/WAPL/PPP2R1B/RBL1/AURKB/ANAPC10/MCM7/SMAD4/PPP2R5E/YWHAH/PPP2R5C/HDAC2/CCNB1/MAD2L2/NIPBL/ANAPC5/MCM5/PRKDC/RBX1/ATR/CHEK1/CDKN1C/CDK1/CDCA5/CDC14A/SMC3/MTBP/RBL2/TP53/NDC80/MCM6/STAG1/CDC25B/YWHAZ/ANAPC15/CDKN2D/PDS5B/CCNA2/CDC6/SGO1/STAG2/MAU2/FBXO5/DDX11/ORC4/TFDP2/TTK/BUB1B/ORC3/CDC20/PPP2CA/MDM2/ORC2/ESCO1/MCM4/CDC45/PLK1/HDAC8/ORC1/DBF4B/CDC25A/CCNB2/MAD1L1/ANAPC7/ANAPC1/MCM2/CDK2/CCNE2/E2F5/ESCO2/CDT1/ESPL1/ORC5/CDC25C/PKMYT1/ANAPC4/CDC23/ZBTB17/TRIP13	13.6079921018372
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	73/2062	108/9376	3.07346337608219	KPNA1/NUP210/IPO7/POM121/NUP214/TNPO3/KPNB1/NUP54/NUP42/RNPS1/NUP160/XPO1/NUP50/IPO11/KPNA6/AHCTF1/RANGAP1/NUP88/CSE1L/KPNA2/DDX39B/RBM8A/PNN/MAGOH/KPNA3/NUP62/NUP98/RANBP2/ALYREF/UPF3B/DDX19B/ACIN1/UPF1/UPF2/THOC2/MAGOHB/UBE2I/XPO4/TMEM33/SRRM1/NUP205/NUP155/NUP107/IPO9/NCBP1/THOC1/NXT1/UPF3A/POM121C/XPO6/CASC3/RANBP17/NUP93/TPR/SENP2/RAN/SUMO1/RAE1/PYM1/NUP37/NUP153/NUP43/IPO8/NUP133/THOC3/SEH1L/AAAS/THOC6/DDX19A/NUP85/XPO5/NXT2/NUP35	11.5071486828715
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	31/2062	36/9376	3.91550813665266	PRIM2/RNASEH2C/PCNA/RNASEH2B/RPA1/MCM3/POLA1/POLE3/RFC2/MCM7/DNA2/RFC1/MCM5/RFC3/FEN1/LIG1/MCM6/RPA2/RPA3/POLE/PRIM1/RFC4/MCM4/POLD1/POLD2/RFC5/SSBP1/MCM2/POLD3/POLA2/POLE2	9.30560386177589
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	93/2062	214/9376	1.97605083532003	BST2/CUL1/RAC2/PLCG2/PTK2B/CASP3/PPP3CC/TRAF5/SAMHD1/APOBEC3G/MAPK1/CD247/KRAS/CGAS/ITPR1/WEE1/MAP2K1/AP1S3/BCL2/NFKB1/PPP3CA/TAB2/TBK1/NFATC2/CD3E/PIK3CD/PPP3R1/CASP8/AP1S2/TAPBP/NFATC3/FASLG/CALM3/MAPK14/LIMK1/TRAF6/CUL5/RIPK1/CCNB1/APOBEC3D/RBX1/CYCS/ATR/CHEK1/HLA-F/BID/CDK1/BAX/APOBEC3C/DDB1/MAP2K3/BCL2L1/GNGT2/TNFRSF1B/CRK/MAP3K7/MAPK8/RPS6KB2/IRAK4/DCAF1/AP1B1/IKBKB/TAP1/APOBEC3H/AP1M1/GNAI2/IRF3/TAP2/CHUK/CUL4A/CALM1/PIK3CB/CFL1/IRAK1/PXN/AP1G2/MAP2K7/HLA-E/CCNB2/GNB1/GNB5/GNAI3/ITPR3/CRKL/TRAF2/GNAQ/GNG5/PAK4/RELA/PAK1/CDC25C/HLA-A/TAB1	7.66896350562727
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	69/2062	142/9376	2.20947801259546	CUL1/UBE3C/UBE2N/HERC1/UBA6/UBE4A/HUWE1/PIAS1/UBE2S/UBE2G1/UBE2J1/UBE2D2/BIRC6/CDC27/SOCS1/WWP2/UBE2C/UBE2A/MAP3K1/FZR1/UBA2/CBL/SAE1/ANAPC10/UBE2K/ITCH/BRCA1/FBXW8/TRAF6/CUL5/HERC3/ANAPC5/RBX1/UBE2I/UBA3/MGRN1/DDB2/UBE2O/DDB1/UBE3A/CUL2/COP1/FANCL/BIRC3/UBE2G2/RCHY1/ANAPC15/CUL3/UBE2H/FBXW7/FBXO4/CDC20/BIRC2/PML/MDM2/SMURF2/TRIM37/CUL4A/SMURF1/UBE2E3/PRPF19/ANAPC7/UBE3B/ANAPC1/KEAP1/ANAPC4/CDC23/RHOBTB2/UBE2D3	7.71080473490302
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	94/2062	224/9376	1.908133573507	KAT2B/IL2RB/SLC25A5/IL2RG/MAP2K4/PPP3CC/CCND3/CDKN2A/MAPK1/KRAS/TGFBR1/ETS1/PRKACB/TGFB1/MAP2K1/BUB3/RANBP1/EP300/NFKB1/ITGAL/PPP3CA/MAD2L1/XPO1/NFATC2/CD3E/CDC27/E2F3/PIK3CD/VDAC3/PPP3R1/MAP3K1/PTTG1/CCND2/NFATC3/DLG1/ANAPC10/CREB1/SMAD4/ADCY7/POLB/RELB/ANAPC5/ATR/CHEK1/HLA-F/FDPS/ICAM1/BAX/TP53/ETS2/JAK3/BCL2L1/ANAPC15/MAPK8/TBPL1/CCNA2/VDAC1/ATF2/IKBKB/BUB1B/CDC20/ELK4/RAN/CRTC3/RANBP3/VAC14/CHUK/PIK3CB/TRRAP/SLC2A1/HLA-E/TLN2/CCNB2/ATF6B/MAD1L1/TBP/NFKB2/ANAPC7/IL1R2/ADCY9/ANAPC1/NFYB/CDK2/CCNE2/MAP3K3/RELA/JAK1/TCF3/ESPL1/MAP3K14/ANAPC4/KAT5/HLA-A/CDC23	7.30412548646131
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	65/2062	138/9376	2.14172254319009	RAC2/SKAP2/WIPF1/ARPC5L/VAV3/LCP2/ZAP70/ARHGEF1/FYB1/RPS6KA3/PTK2B/MAP2K4/MAPK1/ARHGEF7/ACTR2/ACTB/GSK3B/MAP2K1/ARPC1B/WAS/NFKB1/WIPF2/TAB2/TBK1/NFATC2/PIK3CD/ARF6/NFATC3/MAPK14/LIMK1/TRAF6/ACTR3/PYCARD/GIT2/ELMO1/ROCK1/MAP2K3/CRK/IL18/MAP3K7/MAPK8/ARPC2/ITGA4/VAV1/IRAK4/WIPF3/IKBKB/IRF3/CHUK/ARPC4/PIK3CB/RPS6KA2/IRAK1/ARPC3/PXN/MAP2K7/ELMO2/LAT/RPS6KA1/CRKL/TRAF2/GNAQ/RHOA/RELA/TAB1	7.17403731289583
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	51/2062	103/9376	2.25144783554472	SMG1/WDR33/PPP1CA/PPP2R2A/FIP1L1/RNMT/CPSF6/PPP2R5A/RNGTT/RNPS1/NUDT21/PPP2R1B/PPP1CC/FUS/PPP2R5E/DDX39B/RBM8A/PPP2R5C/DAZAP1/PNN/PAPOLG/MAGOH/SMG7/ALYREF/MSI2/UPF3B/DDX19B/ACIN1/UPF1/UPF2/MAGOHB/HBS1L/SRRM1/PABPN1/NCBP1/TARDBP/NXT1/PPP2R3C/UPF3A/SYMPK/PPP2R2B/CASC3/SMG5/PPP2CA/PYM1/CPSF7/PAPOLA/CSTF3/DDX19A/CPSF4/NXT2	6.78068742236742
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	19/2062	23/9376	3.75625184497955	PCNA/RPA1/MSH3/RFC2/RFC1/RFC3/MSH2/LIG1/RPA2/RPA3/RFC4/POLD1/POLD2/RFC5/SSBP1/MLH1/PMS2/POLD3/EXO1	7.02683634647301
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	62/2062	138/9376	2.04287381042747	CUL1/RPS6KA3/PPP3CC/PPP1CA/MAPK1/BUB1/ITPR1/PRKACB/MAP2K1/PPP2R5A/SMC1A/PPP3CA/MAD2L1/CDC27/PPP3R1/SPDYE2/PTTG1/PPP2R1B/ANAPC10/CALM3/MAPK14/PPP1CC/PPP2R5E/YWHAH/ADCY7/PPP2R5C/CCNB1/MAD2L2/ANAPC5/CAMK2G/RBX1/SPDYA/CDK1/SMC3/AURKA/YWHAZ/ANAPC15/SGO1/FBXO5/CDC20/PPP2CA/CALM1/RPS6KA2/PLK1/CCNB2/CPEB3/MAD1L1/ANAPC7/ITPR3/ADCY9/ANAPC1/RPS6KA1/CDK2/CCNE2/CAMK2D/REC8/ESPL1/CDC25C/CPEB2/PKMYT1/ANAPC4/CDC23	6.55291924756441
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	28/2062	44/9376	2.89357199541487	PCNA/PARP4/PARP1/MBD4/POLE3/RFC2/POLB/RFC1/TDP1/RFC3/FEN1/HMGB1/LIG1/POLG/POLE/UNG/PNKP/RFC4/POLD1/POLD2/RFC5/NEIL3/TDG/PARG/POLD3/POLE2/SMUG1/XRCC1	6.68456708155112
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	82/2062	205/9376	1.8188166828322	CD58/RUNX3/ISG15/CDK6/SYK/PLCG2/CASP3/MAP2K4/CCND3/TRAF5/CD247/BCL2/BCL2L11/NFKB1/EIF2AK2/ITGAL/TAB2/TBK1/CD3E/E2F3/PIK3CD/NFKBIB/CASP8/CCND2/TAPBP/MAPK14/IRF9/IRF7/IFNAR2/TRAF6/HDAC2/RIPK1/RELB/CYCS/PSMD14/ADRM1/HLA-F/SNW1/BID/ICAM1/PSMD1/BAX/DDB2/TP53/MAP2K3/JAK3/MAP3K7/SIN3A/MAPK8/CCNA2/IRAK4/IKBKB/TAP1/PSMD7/RBPJ/PSMD4/OAS2/MDM2/IRF3/TAP2/CHUK/PIK3CB/IRAK1/MAP2K7/OAS3/APAF1/HLA-E/TYK2/NFKB2/OAS1/ENTPD1/CDK2/TRAF2/CCNE2/RELA/LYN/JAK1/TNFAIP3/NFKBIE/MAP3K14/HLA-A/TAB1	6.29372491624347
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	35/2062	63/9376	2.52613428171139	MNAT1/POLR2J/PCNA/POLR2G/CCNH/RPA1/POLR2K/POLR2J3/POLE3/RFC2/POLR2B/RFC1/RAD23A/RBX1/RFC3/DDB2/DDB1/LIG1/POLR2I/RPA2/RPA3/POLE/ERCC3/POLR2A/GTF2H1/XPA/XPC/RFC4/CUL4A/POLD1/POLD2/RFC5/POLR2D/POLD3/POLE2	6.45313442516088
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	66/2062	157/9376	1.91149523991919	CDK6/KIR2DL4/HIPK2/SLC25A5/PPP3CC/CCND3/PPP1CA/CDKN2A/MAPK1/KRAS/ITPR1/HIPK1/TGFBR1/ETS1/TGFB1/MAP2K1/RBBP4/TRPM7/NFKB1/PPP3CA/RASSF5/NFATC2/E2F3/RRAS2/PIK3CD/VDAC3/PPP3R1/CCND2/RBL1/NFATC3/CALM3/MAPK14/PPP1CC/CCNB1/MRE11/ATR/CHEK1/HLA-F/CDK1/RBL2/TP53/MAP2K3/CCNA2/VDAC1/LIN52/PPID/IGFBP3/LIN54/EIF4EBP1/MYBL2/MDM2/CALM1/PIK3CB/FOXM1/ZFP36L2/HLA-E/CDC25A/CCNB2/SERPINE1/FOXO3/ITPR3/CDK2/CCNE2/E2F5/RELA/HLA-A	6.11525842145795
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	40/2062	78/9376	2.33181626004128	DHX36/TENT4B/LSM5/ZCCHC7/CNOT1/LSM6/MTREX/EXOSC8/PARN/LSM8/TENT4A/PAN3/CNOT4/DCP1A/CNOT7/DDX6/EXOSC9/CNOT9/LSM3/XRN1/CNOT2/PFKP/ENO1/DCP2/NUDT16/LSM4/EXOSC1/BTG3/CNOT10/PNPT1/CNOT6/EXOSC3/CNOT6L/HSPD1/EXOSC10/BTG2/HSPA9/DIS3L/EXOSC2/CNOT3	6.27118097553781
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	26/2062	41/9376	2.88348986302666	RBBP8/TOPBP1/RPA1/BARD1/BLM/BRIP1/BRCA1/BRCA2/RAD51B/MRE11/BABAM2/RPA2/RPA3/UIMC1/BABAM1/RAD51C/POLD1/POLD2/RAD51/SSBP1/BRCC3/RAD51D/POLD3/TOP3A/XRCC3/RAD54B	6.41727344123521
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	41/2062	83/9376	2.24612903602772	MTF2/SFMBT1/TFDP1/SFMBT2/EZH2/SUZ12/RBBP4/EP300/JARID2/LCOR/DCAF7/PHF19/UBE2D2/AURKB/YAF2/RBBP7/YY1/HDAC2/L3MBTL4/OGT/CSNK2B/ASXL2/BCOR/AUTS2/KDM2A/KDM2B/MGA/FOXK2/CBX3/AEBP2/SCMH1/EED/RNF2/CBX4/MBD6/TEX10/WDR5/L3MBTL2/PCGF6/FBRSL1/UBE2D3	6.0544763056309
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	38/2062	75/9376	2.30383446492079	CDK6/CASP3/CCND3/CDKN2A/BCL2/RRM2/CASP8/CCND2/PMAIP1/CD82/SESN1/GTSE1/CCNB1/CYCS/ATR/CHEK1/BID/CDK1/BAX/DDB2/TP53/COP1/RCHY1/BCL2L1/CCNG1/PPM1D/IGFBP3/SIVA1/MDM2/ZMAT3/APAF1/CCNB2/SERPINE1/CDK2/GORAB/CCNE2/TNFRSF10A/THBS1	6.01922748519065
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	53/2062	122/9376	1.9753541842235	PTPRC/VAV3/ITK/LCP2/MAP3K8/ZAP70/CARD11/PPP3CC/MAPK1/CD247/KRAS/PPP2R2A/GSK3B/MAP2K1/PPP2R5A/PTPN6/NFKB1/PPP3CA/MALT1/FYN/NFATC2/CD3E/PIK3CD/NFKBIB/PPP3R1/PPP2R1B/NFATC3/DLG1/MAPK14/PPP2R5E/RASGRP1/PPP2R5C/SOS1/NCK1/MAP3K7/MAPK8/TEC1/PPP2R3C/VAV1/IKBKB/PPP2R2B/GRAP2/PPP2CA/CHUK/PIK3CB/MAP2K7/LAT/RHOA/PAK4/RELA/PAK1/NFKBIE/MAP3K14	5.75744780961854
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	51/2062	117/9376	1.98204382103509	DPF3/ARID1A/SMARCA2/SMARCB1/ACTB/BAZ1B/RBBP4/BRD7/ACTR6/CHD3/GATAD2B/SMARCC1/POLE3/EP400/MEAF6/ARID2/SMARCA5/UCHL5/RBBP7/YY1/HDAC2/INO80/PBRM1/RSF1/BAZ2A/SMARCD1/BPTF/DPF2/CDK2AP2/BCL7B/SMARCD2/SMARCA4/SRCAP/PHF10/ACTL6A/BAZ1A/ING3/TRRAP/CHRAC1/RUVBL2/MTA2/MCRS1/SS18L1/ARID1B/YEATS4/INO80E/MRGBP/EPC1/KAT5/INO80C/CECR2	5.6753708722851
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	91/2062	253/9376	1.63549721479971	CUL1/ARPC5L/SEPTIN6/HCLS1/ACTN4/RPS6KA5/PLCG2/UBE2N/DIAPH1/TRAF5/MAPK1/ACTR2/ACTB/CGAS/ITPR1/GSK3B/CYTH4/PFN1/BCL2/ARPC1B/NFKB1/CYTH1/RPTOR/TAB2/TBK1/UBE2D2/MALT1/PIK3CD/NFKBIB/ARF6/GLMN/MAPK14/SEPTIN9/SEPTIN7/TRAF6/RIPK1/ACTR3/PYCARD/RBX1/CYCS/ELMO1/ATG5/BAX/ROCK1/TP53/ILK/TIFA/BCL2L1/CRK/IL18/MAP3K7/PLCB1/MAPK8/ATG16L1/RPS6KB2/CBX3/ARPC2/VDAC1/IKBKB/TNIP1/PPID/GSK3A/C3/MDM2/IRF3/U2AF1/CHUK/ARPC4/PIK3CB/FNBP1L/ARPC3/MYL12A/PXN/HKDC1/TLN2/PIK3R4/CAST/FOXO3/CYTH2/ELMO2/ITPR3/FNBP1/CRKL/TRAF2/RHOA/RELA/PLCB2/NOD1/RNF31/TAB1/UBE2D3	5.44073489910285
Human Diseases	Infectious disease: viral	hsa05162	Measles	56/2062	136/9376	1.8723112911508	CDK6/CASP3/IL2RB/IL2RG/CCND3/MX1/GSK3B/BCL2/NFKB1/EIF2AK2/TAB2/TBK1/CD3E/PIK3CD/ADAR/NFKBIB/CASP8/CCND2/FASLG/CD46/IRF9/IRF7/IFNAR2/TRAF6/CYCS/CSNK2B/BID/CSNK2A1/MSN/BAX/TP53/JAK3/RCHY1/BCL2L1/MAP3K7/MAPK8/HSPA1B/IRAK4/IKBKB/OAS2/IRF3/HSPA8/CHUK/PIK3CB/IRAK1/OAS3/APAF1/IFIH1/TYK2/OAS1/EIF3H/CDK2/CCNE2/RELA/JAK1/TNFAIP3	5.4407334948497
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	55/2062	133/9376	1.88035559315359	KLRC3/KLRC1/KLRC2/LAT2/HCST/KLRK1/RAC2/TYROBP/VAV3/LCP2/ZAP70/SYK/PLCG2/KIR2DL4/PTK2B/CASP3/PPP3CC/PRF1/MAPK1/CD247/KRAS/MAP2K1/GZMB/PTPN6/FCER1G/KLRD1/ITGAL/PPP3CA/SH2D1B/FYN/NFATC2/PIK3CD/PPP3R1/FASLG/TNFSF10/IFNAR2/SOS1/BID/ICAM1/BRAF/KIR2DL3/VAV1/NCR1/NCR3/PIK3CB/KIR2DL1/HLA-E/LAT/MICB/KIR3DL1/TNFRSF10A/CD48/PAK1/SH3BP2/HLA-A	5.42912651838998
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	76/2062	205/9376	1.68573253530789	RASA2/SP100/CDK6/SYK/ACTN4/KAT2B/CASP3/CCND3/TRAF5/CDKN2A/MAPK1/KRAS/PRKACB/RANBP1/EP300/HDAC9/NFKB1/EIF2AK2/PIK3CD/REL/VDAC3/CASP8/CCND2/PMAIP1/RBL1/DLG1/CREB1/IRF9/YWHAH/IRF7/POLB/HDAC2/CHEK1/HLA-F/SNW1/CDK1/BAX/RBL2/UBR4/DDB1/TP53/UBE3A/JAK3/YWHAZ/GTF2B/TBPL1/CCNA2/ATF2/RBPJ/CDC20/GTF2H1/SND1/C3/MDM2/IRF3/VAC14/PIK3CB/HDAC8/HDAC7/PXN/HDAC5/HDAC3/HLA-E/ATF6B/MAD1L1/TBP/NFKB2/CDK2/TRAF2/CCNE2/RHOA/RELA/LYN/JAK1/HLA-A/DNAJA3	5.27079141624002
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	68/2062	180/9376	1.71777131156375	BST2/SP100/SYK/CASP3/PPP1CA/TRAF5/CGAS/POU2F1/BCL2/NFKB1/EIF2AK2/TAB2/TBK1/SRSF4/ZC3HAV1/PILRB/PIK3CD/CASP8/TAPBP/FASLG/PPP1CC/IRF9/IRF7/IFNAR2/TRAF6/JAK2/ALYREF/CYCS/HLA-F/BID/BAX/TP53/BIRC3/BCL2L1/SRSF1/MAP3K7/SRPK1/IRAK4/IKBKB/TAP1/HCFC2/SRSF2/BIRC2/PML/OAS2/EIF4EBP1/SRSF7/C3/IRF3/TAP2/CHUK/PIK3CB/IRAK1/OAS3/APAF1/HLA-E/EIF2B5/IFIH1/SRSF9/TYK2/TNFSF14/OAS1/TRAF2/RELA/JAK1/HLA-A/TAB1/TNFRSF14	5.16268179717906
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	63/2062	163/9376	1.75744556776731	MMP9/STAT4/PTK2B/CASP3/MAP2K4/MAPK1/KRAS/TGFBR1/TGFB1/MAP2K1/PCNA/BCL2/EP300/NFKB1/TAB2/TBK1/NFATC2/E2F3/PIK3CD/VDAC3/CASP8/MAP3K1/NFATC3/FASLG/MAPK14/CREB1/SMAD4/IRF7/TRAF6/JAK2/SOS1/CYCS/BID/BIRC5/BAX/BRAF/DDB2/DDB1/TP53/MAP2K3/JAK3/YWHAZ/CASP10/MAP3K7/MAPK8/CCNA2/IRAK4/ATF2/IKBKB/IRF3/CHUK/PIK3CB/IRAK1/MAP2K7/APAF1/ATF6B/IFIH1/TYK2/CDK2/CCNE2/RELA/JAK1/TAB1	5.17961149393899
Genetic Information Processing	Transcription	hsa03040	Spliceosome	86/2062	243/9376	1.60924109797911	DDX46/RBM25/CCDC12/LSM5/TRA2B/PRPF38B/SRSF10/BCAS2/LSM6/SNRPD1/SRSF4/SNRPD3/SNRNP70/SNRPC/AQR/LSM8/SF3B2/SNRPF/DHX15/SNRPA1/TXNL4A/FUS/EFTUD2/DDX39B/U2SURP/TCERG1/RBM8A/MAGOH/PRPF38A/USP39/CDC5L/PRPF8/U2AF2/LSM3/ALYREF/PRPF6/ACIN1/SNW1/SNRPE/THOC2/SF1/MAGOHB/PPIH/SNRPG/PRPF40A/SNRNP40/CTNNBL1/SF3B4/SRSF1/SNRPB/NCBP1/LSM4/THOC1/SNRPA/RP9/SLU7/HSPA1B/SF3A1/SNRNP200/SNU13/DDX23/DHX8/SRSF2/CASC3/CWC25/BUD13/PUF60/YJU2/SRSF7/SF3A3/RBM22/HSPA8/U2AF1/PRPF3/WBP11/PRPF18/THOC3/SRSF9/PRPF19/CRNKL1/THOC6/RBMX2/DHX16/PPIL1/SF3A2/HNRNPA3	5.10902574075763
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	46/2062	110/9376	1.90149016841548	RPS6KA3/STK10/MAPK1/KRAS/BUB1/PRKACB/MAP2K1/KIF22/MAD2L1/CDC27/PIK3CD/FZR1/SPDYE2/ANAPC10/MAPK14/ADCY7/CCNB1/MAD2L2/ANAPC5/SPDYA/CDK1/BRAF/AURKA/CDC25B/ANAPC15/MAPK8/CCNA2/GNAI2/PIK3CB/RPS6KA2/PLK1/CDC25A/CCNB2/CPEB3/MAD1L1/GNAI3/ANAPC7/ADCY9/ANAPC1/RPS6KA1/CDK2/CDC25C/CPEB2/PKMYT1/ANAPC4/CDC23	5.04967793525402
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	117/2062	368/9376	1.44566271665331	NUP210/CASP3/TUBA1B/PPP3CC/NDUFB3/ANXA11/ACTB/POM121/NDUFV1/NUP214/NDUFA7/PFN1/BCL2/NUP54/NDUFS7/NDUFS8/ATXN2L/NDUFS6/PPP3CA/NUP160/TBK1/NUP50/NDUFAB1/UQCRC2/PPP3R1/NDUFB9/NUP88/MAPK14/RAB8A/FUS/COX8A/NUP62/COX5A/NUP98/RANBP2/KLC1/ALYREF/CYCS/PSMD14/ADRM1/BID/PSMA5/PSMD1/DCTN4/BAX/SETX/TP53/MAP2K3/ATF6/ATG101/NUP205/NUP155/NUP107/TOMM40/NDUFA3/BCL2L1/PSMA3/TNFRSF1B/COX7B/PSMA4/NCBP1/TARDBP/NDUFA9/NDUFB4/VDAC1/TUBA4A/NXT1/POM121C/TUBB/NDUFB6/COX6B1/PSMD7/NUP93/PSMD4/TPR/MT-CO2/SRSF7/ATG2A/SPG11/COX7A2/RAE1/EIF2AK3/TUBA1C/PSMA6/PSMB3/UQCRQ/NUP37/SDHB/NUP153/DNAH14/NDUFB8/DCTN5/ATG2B/NUP43/APAF1/TUBB4B/PIK3R4/NUP133/SEH1L/UQCR11/COX6A1/ITPR3/SIGMAR1/COX6A2/TRAF2/UQCR10/VAPB/MT-ND4/NUP85/ATP5PF/NDUFC2/KLC2/NDUFA13/NXT2/HNRNPA3/HNRNPA2B1/NUP35	4.63093317980744
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	83/2062	248/9376	1.52179218422452	PTPRC/KPNA1/ARPC5L/CASP3/CYFIP2/MAP2K4/TUBA1B/MAPK1/ACTR2/ACTB/RHOH/MAP2K1/CYTH4/PFN1/BCL2/ARPC1B/NFKB1/PIK3CG/CYTH1/NCKAP1L/TAB2/SNX18/PIK3CD/PIK3C2A/CASP8/ABI1/ARF6/VPS41/MAPK14/CSE1L/TNFSF10/DNM2/TRAF6/KPNA3/RIPK1/LEF1/ACTR3/EXOC2/KLC1/PYCARD/CYCS/ELMO1/DCTN4/BAX/MLKL/MAP2K3/BIRC3/IL18/MAP3K7/MAPK8/ARPC2/TUBA4A/IRAK4/GSDMD/TUBB/IKBKB/BIRC2/DYNC1H1/TUBA1C/CHUK/ARPC4/PIK3CB/IRAK1/DCTN5/ARPC3/MYL12A/MAP2K7/DYNLRB1/TUBB4B/CYTH2/ELMO2/GAPDH/TRAF2/TNFRSF10A/RHOA/RELA/PAK1/NOD1/CTNNB1/KLC2/RAB5B/EXOC4/TAB1	4.42168789895304
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	26/2062	54/9376	2.18931637748321	USP1/FANCI/CENPX/RPA1/BLM/BRIP1/UBE2T/BRCA1/BRCA2/ATR/FANCB/FANCD2/FANCA/RPA2/RPA3/FANCL/FANCC/FANCM/RAD51C/POLH/RAD51/ATRIP/MLH1/PMS2/TOP3A/RMI1	4.65363396629458
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	74/2062	216/9376	1.55778280705536	MMP9/VAV3/ARHGEF1/APOA1/CASP3/MAP2K4/PPP3CC/LDLR/MAPK1/KRAS/ITPR1/GSK3B/POU2F1/BCL2/NFKB1/PPP3CA/RAP1A/TAB2/TBK1/NFATC2/PIK3CD/PPP3R1/CASP8/NFATC3/FASLG/CALM3/MAPK14/TNFSF10/IRF7/TRAF6/JAK2/PYCARD/CAMK2G/CYCS/BID/ICAM1/HSPA4/RXRA/BAX/TP53/MAP2K3/ATF6/ERO1A/BCL2L1/IL18/MAP3K7/PLCB1/MAPK8/VAV1/HSPA1B/IRAK4/IKBKB/IRF3/EIF2AK3/CCL3/HSPA8/MIB2/CHUK/CALM1/PIK3CB/IRAK1/HSPD1/MAP2K7/APAF1/TRAF2/CASP6/CAMK2D/TNFRSF10A/RHOA/RELA/LYN/PLCB2/NCF1/TAB1	4.40348734901629
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	77/2062	227/9376	1.54238859667488	RAC2/ARHGEF1/CCR1/CDK6/PTK2B/CASP3/PPP3CC/TRAF5/CDKN2A/MAPK1/KRAS/CGAS/ITPR1/PRKACB/GSK3B/MAP2K1/NFKB1/GNA13/PPP3CA/TBK1/NFATC2/E2F3/PIK3CD/PPP3R1/CASP8/TAPBP/NFATC3/FASLG/CALM3/MAPK14/CREB1/ADCY7/RIPK1/SOS1/CYCS/HLA-F/BID/BAX/ROCK1/TP53/PTGER2/GNGT2/CRK/PLCB1/RPS6KB2/ATF2/IKBKB/TAP1/EIF4EBP1/GNAI2/MDM2/IRF3/TAP2/CCL3/CHUK/CALM1/PIK3CB/PTGER4/PXN/HLA-E/GNB1/ATF6B/GNB5/GNAI3/SP1/ITPR3/ADCY9/CRKL/TRAF2/GNAQ/RHOA/GNG5/RELA/JAK1/PLCB2/CTNNB1/HLA-A	4.3922712808742
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	83/2062	250/9376	1.50961784675073	RAB11FIP1/ACAP1/ARAP2/WIPF1/ARPC5L/VPS37B/SMAP2/IL2RB/STAM/IL2RG/LDLR/GRK2/ACTR2/TGFBR1/CYTH4/ARPC1B/CYTH1/WIPF2/GBF1/SNX5/VPS36/IGF2R/CBL/ARF6/VPS26A/VTA1/RAB8A/ARFGAP3/ITCH/PLD1/DNM2/PSD4/ARFGEF1/TRAF6/ACTR3/VPS29/RAB11FIP3/GIT2/EPS15L1/HLA-F/TFRC/SMAP1/SNX4/PDCD6IP/CAPZB/ASAP1/AGAP2/RAB22A/ARPC2/IST1/HSPA1B/WIPF3/EHD4/ARFGEF2/PML/CAPZA1/TSG101/AGAP3/SH3GLB2/MDM2/SMURF2/HSPA8/ARPC4/SMURF1/ARPC3/ZFYVE27/CHMP6/VPS45/HLA-E/ACAP2/WASHC1/GRK5/HGS/CYTH2/RHOA/ARF5/CHMP1A/RAB5B/GIT1/ARRB2/HLA-A/PARD6B/AGAP4	4.33637559261762
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	46/2062	120/9376	1.74303265438086	ARHGDIB/RPS6KA5/PLCG2/RPS6KA3/MAPK1/KRAS/GSK3B/MAP2K1/BCL2/NFKB1/SH2B3/RAP1A/RAPGEF1/PIK3CD/NFKBIB/MAP3K1/FASLG/CALM3/MAPK14/MATK/ARHGDIA/TRAF6/SOS1/CAMK2G/BAX/BRAF/TP53/CRK/MAPK8/IRAK4/IKBKB/CALM1/PIK3CB/RPS6KA2/IRAK1/SORT1/MAP2K7/FOXO3/RPS6KA1/CRKL/CAMK2D/RHOA/MAP3K3/RELA/NFKBIE/PSEN2	4.34950005863286
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	33/2062	78/9376	1.92374841453406	PIP4K2A/PLCG2/SACM1L/INPP5D/PIK3CG/PI4KA/INPP4A/PIK3CD/INPP5A/PIK3C2A/ITPK1/MTMR3/PIKFYVE/PLCB1/INPP5B/IMPA1/IPPK/PI4K2B/IP6K1/PIK3CB/PLCH2/MTMR14/MTMR1/INPP5F/SYNJ2/SYNJ1/PLCB2/TPI1/ITPKB/ISYNA1/MTMR4/INPPL1/ITPKC	4.34969421624995
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	39/2062	98/9376	1.80953700587898	PIP4K2A/PLCG2/SACM1L/DGKZ/ITPR1/INPP5D/PI4KA/DGKE/INPP4A/PIK3CD/INPP5A/DGKD/PIK3C2A/CALM3/ITPK1/MTMR3/PIKFYVE/PLCB1/INPP5B/IMPA1/CDS2/IPPK/PI4K2B/IP6K1/CALM1/PIK3CB/MTMR14/DGKQ/MTMR1/INPP5F/ITPR3/SYNJ2/SYNJ1/PLCB2/ITPKB/DGKB/MTMR4/INPPL1/ITPKC	4.2773525820453
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	31/2062	73/9376	1.93093551944515	BST2/KAT2B/CCNT1/SAMHD1/MDFIC/APOBEC3G/SMARCB1/MX1/CPSF6/TNPO3/EP300/CCNT2/ELL/XPO1/PSIP1/APOBEC3D/RANBP2/PIN1/APOBEC3C/PDCD6IP/SUPT5H/APOBEC3H/RAN/TSG101/NUP153/MLLT3/NELFA/CHMP6/CPSF7/HGS/ELL2	4.2395719606969
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	67/2062	200/9376	1.52325897187197	WIPF1/ARPC5L/HCLS1/ARHGEF1/CASP3/EZR/CYFIP2/TUBA1B/MAPK1/SEC24B/ACTR2/ACTB/CYTH4/PTPN6/MYO1E/ARPC1B/NFKB1/MYO1G/GNA13/CYTH1/NCKAP1L/WIPF2/TAB2/FYN/NFKBIB/CASP8/ABI1/ARF6/FASLG/MAPK14/TNFSF10/TRAF6/RIPK1/ACTR3/PYCARD/CYCS/BAX/ROCK1/NCK1/IL18/MAP3K7/MAPK8/ARPC2/TUBA4A/MYO1F/IRAK4/TUBB/WIPF3/IKBKB/TUBA1C/CHUK/ARPC4/IRAK1/SEC24D/SEC24C/ARPC3/TUBB4B/CYTH2/MYH9/GAPDH/TRAF2/CLDN4/TNFRSF10A/RHOA/RELA/PAK1/TAB1	3.97152654465409
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	31/2062	75/9376	1.87944390559328	CASP3/CDKN2A/MAPK1/BCL2/TOP2B/GSTP1/MSH3/PIK3CD/CASP8/MGST2/PMAIP1/FASLG/TOP2A/BRCA1/CYCS/BID/BIRC5/MSH2/BAX/TP53/BIRC3/BCL2L1/BIRC2/XPA/MDM2/POLH/PIK3CB/APAF1/MLH1/SLC31A1/ATP7A	4.06000383534274
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	44/2062	119/9376	1.68125911858439	MMP9/MAP3K8/RPS6KA5/CASP3/MAP2K4/TRAF5/MAPK1/CYLD/MAP2K1/CSF1/NFKB1/TAB2/DNM1L/PIK3CD/CASP8/MAPK14/CREB1/ITCH/RIPK1/IRF1/ICAM1/MLKL/MAP2K3/BIRC3/BCL3/CASP10/TNFRSF1B/MAP3K7/MAPK8/ATF2/IKBKB/BAG4/BIRC2/CHUK/PIK3CB/MAP2K7/ATF6B/NOD2/TRAF2/FRMD8/RELA/TNFAIP3/MAP3K14/TAB1	3.97102999788073
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	49/2062	137/9376	1.62631418720398	CTSW/CASP3/LMNB1/TUBA1B/CTSD/PRF1/MAPK1/KRAS/ACTB/ITPR1/MAP2K1/GZMB/BCL2/BCL2L11/PARP4/NFKB1/CASP2/PARP1/PIK3CD/CASP8/PMAIP1/FASLG/TNFSF10/RIPK1/CYCS/BID/BIRC5/BAX/TP53/BIRC3/BCL2L1/CASP10/MAPK8/TUBA4A/IKBKB/BIRC2/EIF2AK3/TUBA1C/CHUK/PIK3CB/APAF1/LMNB2/ITPR3/TRAF2/CASP6/TNFRSF10A/RELA/DFFB/MAP3K14	3.92096115807476
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	64/2062	193/9376	1.5078273018298	RAC2/VAV3/ITK/XCL2/DOCK2/TIAM1/CCR1/PLCG2/PTK2B/XCL1/GRK2/MAPK1/KRAS/PRKACB/GSK3B/MAP2K1/WAS/PIK3R6/NFKB1/PIK3CG/CXCR3/RAP1A/FGR/PIK3CD/NFKBIB/ADCY7/JAK2/SOS1/ELMO1/ROCK1/BRAF/JAK3/GNGT2/CRK/PLCB1/VAV1/IKBKB/CCL28/RASGRP2/GSK3A/GNAI2/CCL3/CHUK/PIK3CB/PREX1/PXN/GNB1/GRK5/GNB5/FOXO3/GNAI3/CCL8/ADCY9/CRKL/GNAQ/RHOA/GNG5/RELA/LYN/PLCB2/PAK1/NCF1/CCL21/ARRB2	3.78490426296386
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	54/2062	157/9376	1.56395065084298	CASP3/NDUFB3/NDUFV1/TGFB1/GSK3B/NDUFA7/BCL2L11/NDUFS7/NFKB1/NDUFS8/NDUFS6/ADIPOR2/PIK3CD/NDUFAB1/UQCRC2/CASP8/NDUFB9/FASLG/MAPK14/COX8A/ITCH/COX5A/CYCS/BID/RXRA/BAX/NDUFA3/COX7B/MAPK8/NDUFA9/NDUFB4/ADIPOR1/IKBKB/NDUFB6/COX6B1/GSK3A/MT-CO2/PRKAA1/COX7A2/EIF2AK3/PIK3CB/UQCRQ/SDHB/NDUFB8/UQCR11/COX6A1/COX6A2/MAP3K11/TRAF2/UQCR10/RELA/NDUFC2/PRKAB1/NDUFA13	3.78356772017804
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	12/2062	20/9376	2.7282250242483	EBP/LBR/FDFT1/DHCR24/SQLE/MSMO1/SOAT1/LSS/SC5D/HSD17B7/TM7SF2/DHCR7	4.10792656391769
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	58/2062	173/9376	1.52444172838537	KPNA1/CDK6/CASP3/SLC25A5/CCND3/MAPK1/MX1/ACTB/HNRNPUL1/MAP2K1/EP300/NFKB1/EIF2AK2/TBK1/XPO1/PIK3CD/ADAR/NFKBIB/KPNA6/CASP8/FASLG/KPNA2/TNFSF10/IRF9/IRF7/IFNAR2/JAK2/NUP98/PYCARD/CYCS/FDPS/BID/ICAM1/BAX/PABPN1/IL18/VDAC1/NXT1/IRAK4/IKBKB/PML/RSAD2/OAS2/RAE1/IRF3/CHUK/PIK3CB/PRSS3/OAS3/APAF1/IFIH1/TYK2/OAS1/TNFRSF10A/RELA/JAK1/CPSF4/NXT2	3.6966477686527
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	17/2062	34/9376	2.27352085354025	POLR2J/POLR2G/POLR2K/POLR3GL/POLR3K/POLR2J3/POLR2B/CRCP/POLR2I/POLR2A/POLR3C/POLR1A/POLR2D/POLR3E/POLR3H/POLR1C/POLR3B	3.94982703922355
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	25/2062	59/9376	1.92671258774598	NT5C3A/NUDT2/UPP1/RRM2/RRM1/DCK/NT5C2/TYMS/CTPS1/CDA/NT5C/NME1/DTYMK/UCK2/UMPS/CMPK1/DUT/TK1/DCTPP1/NME7/CANT1/ENTPD1/AK9/CAD/CMPK2	3.79127695394321
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	74/2062	235/9376	1.43183440988918	DPF3/ARID1A/RPS6KA3/SMARCA2/KRAS/SMARCB1/NDUFB3/ACTB/NDUFV1/PRKACB/NDUFA7/NDUFS7/NDUFS8/NDUFS6/RPTOR/COA1/NDUFAB1/UQCRC2/SMARCC1/NDUFB9/MAPK14/CREB1/COX8A/ACSL3/ADCY7/COX5A/SOS1/NDUFAF8/COX20/MAP2K3/SMARCD1/NDUFA3/COX7B/NDUFA9/RPS6KB2/NDUFB4/COX17/ATF2/NDUFB6/COX6B1/COX14/NDUFAF4/PNPLA2/ACSL5/SMARCD2/SMARCA4/ATP5MG/MT-CO2/PRKAA1/COX7A2/COA6/ACTL6A/RPS6KA2/ATP5MF/UQCRQ/SDHB/NDUFB8/COX10/NDUFAF7/UQCR11/PLIN1/COX6A1/ADCY9/ARID1B/RPS6KA1/COX6A2/UQCR10/MT-ND4/ATP5PF/NDUFC2/PRKAB1/SLC25A20/NDUFAF6/NDUFA13	3.55964601857749
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	38/2062	105/9376	1.64559604637199	SYK/LSP1/PLCG2/PPP3CC/MAPK1/KRAS/KSR1/ITPR1/CYLD/FCER1G/NFKB1/PPP3CA/MALT1/NFATC2/RRAS2/PIK3CD/PPP3R1/CASP8/NFATC3/CALM3/MAPK14/IRF9/RELB/PYCARD/IRF1/BCL3/MAPK8/IKBKB/MDM2/CHUK/CALM1/PIK3CB/NFKB2/ITPR3/RHOA/RELA/PAK1/MAP3K14	3.53219532811743
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	32/2062	85/9376	1.71182746619501	GMPS/NT5C3A/UPP1/RRM2/HPRT1/RRM1/DCK/NT5C2/TYMS/ADK/CTPS1/CDA/NT5C/AK3/PNP/AK2/NME1/DTYMK/UCK2/NUDT16/CMPK1/DUT/TK1/DCTPP1/AMPD3/NME7/ADSL/CANT1/ENTPD1/AK9/IMPDH1/CMPK2	3.50030158729854
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	9/2062	14/9376	2.92309824026604	B3GNT7/FUT8/ST3GAL3/B4GALT1/ST3GAL1/B3GNT2/B4GALT4/B4GALT3/ST3GAL2	3.82325848100325
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	60/2062	187/9376	1.45894386323439	TRAF5/MAPK1/ITPR1/BCL2/TRPM7/NFKB1/GPSM3/TAB2/DNM1L/TBK1/NEK7/VDAC3/NFKBIB/CASP8/PSTPIP1/MAPK14/IRF9/IRF7/IFNAR2/TRAF6/RIPK1/PYCARD/ATG5/CARD8/BIRC3/BCL2L1/IL18/MAP3K7/PLCB1/MAPK8/ATG16L1/VDAC1/IRAK4/GSDMD/IKBKB/GABARAPL1/TRPV2/BIRC2/OAS2/IRF3/CARD16/CHUK/OAS3/IFI16/TYK2/OAS1/ITPR3/BRCC3/NOD2/TRAF2/GBP4/RHOA/RELA/JAK1/PLCB2/TNFAIP3/NOD1/RNF31/DHX33/TAB1	3.36588082732663
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	34/2062	93/9376	1.66235933377137	RAC2/HEG1/ACTN4/MAPK1/ACTB/PTPN1/LMO7/TGFBR1/EP300/PTPN6/WAS/RAP1A/YES1/FYN/IQGAP1/PDCD10/SMAD4/LEF1/CSNK2B/CSNK2A1/ROCK1/PTPRJ/MAP3K7/NECTIN3/FER/NLK/SMURF2/CCM2/SMURF1/MYL12A/AFDN/RHOA/CTNNB1/SORBS1	3.40834422951962
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	34/2062	93/9376	1.66235933377137	MAML3/STAT4/RUNX3/ZAP70/IL2RB/IL2RG/PPP3CC/MAPK1/CD247/GATA3/NFKB1/PPP3CA/NFATC2/CD3E/NFKBIB/PPP3R1/NFATC3/MAPK14/JAK2/MAML1/NOTCH2/JAK3/MAPK8/IKBKB/RBPJ/CHUK/TYK2/LAT/IL4R/NOTCH1/RELA/JAK1/NFKBIE/IL12RB1	3.40834422951962
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	91/2062	308/9376	1.34344414072833	CASP3/SLC25A5/TUBA1B/NDUFB3/ITPR1/POLR2J/NDUFV1/NDUFA7/EP300/POLR2G/NDUFS7/NDUFS8/POLR2K/NDUFS6/HIP1/NRF1/NDUFAB1/UQCRC2/VDAC3/RCOR1/CASP8/POLR2J3/NDUFB9/POLR2B/CREB1/COX8A/HDAC2/COX5A/KLC1/CYCS/PSMD14/ADRM1/HTT/PSMA5/PSMD1/DCTN4/BAX/TP53/POLR2I/ATG101/NDUFA3/PSMA3/COX7B/PSMA4/SIN3A/PLCB1/MAPK8/TBPL1/NDUFA9/NDUFB4/VDAC1/TUBA4A/TUBB/NDUFB6/COX6B1/POLR2A/PSMD7/PSMD4/MT-CO2/ATG2A/COX7A2/TUBA1C/PSMA6/PSMB3/UQCRQ/SDHB/DNAH14/NDUFB8/DCTN5/TFAM/ATG2B/MAP2K7/APAF1/TUBB4B/PIK3R4/TBP/UQCR11/SP1/POLR2D/COX6A1/COX6A2/TRAF2/UQCR10/GNAQ/MT-ND4/PLCB2/ATP5PF/NDUFC2/KLC2/NDUFA13/TAF4	3.25407984346266
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	62/2062	196/9376	1.43834992774996	CCR1/CDK6/SYK/PLCG2/CASP3/MAP2K4/PPP3CC/MAPK1/KRAS/ITPR1/GSK3B/MAP2K1/EP300/PIK3R6/NFKB1/PIK3CG/EIF2AK2/PPP3CA/TBK1/NFATC2/E2F3/PIK3CD/PPP3R1/CASP8/NFATC3/CALM3/MAPK14/CREB1/IRF9/IRF7/IFNAR2/JAK2/LEF1/CYCS/HLA-F/BID/ICAM1/BAX/TP53/GNGT2/MAPK8/IKBKB/C3/IRF3/CHUK/CALM1/PIK3CB/PREX1/MAP2K7/HLA-E/GNB1/TYK2/GNB5/ITPR3/MICB/TRAF2/GNG5/RELA/LYN/JAK1/CTNNB1/HLA-A	3.29291200232549
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	51/2062	156/9376	1.48653286577632	CDK6/CASP3/LDLR/MAPK1/KRAS/MX1/PPP2R2A/PIAS1/GSK3B/MAP2K1/NFKB1/EIF2AK2/TBK1/E2F3/PIK3CD/CASP8/PPP2R1B/FASLG/IRF9/YWHAH/IRF7/IFNAR2/TRAF6/RIPK1/SOS1/CYCS/BID/RXRA/BAX/BRAF/TP53/YWHAZ/IKBKB/PPP2R2B/PSME3/RSAD2/OAS2/PPP2CA/IRF3/CHUK/PIK3CB/OAS3/APAF1/TYK2/OAS1/CDK2/TRAF2/CLDN4/RELA/JAK1/CTNNB1	3.25358016613558
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	64/2062	205/9376	1.41956424025928	MMP9/RAC2/SLC25A5/PPP1CA/CTSD/NDUFB3/NDUFV1/TGFBR1/TGFB1/GSK3B/NDUFA7/NDUFS7/NFKB1/NDUFS8/NDUFS6/PARP1/PIK3CD/NDUFAB1/UQCRC2/VDAC3/MPC1/NDUFB9/MAPK14/PPP1CC/TBC1D4/GFPT1/COX8A/G6PD/COX5A/CAMK2G/REN/MPC2/NDUFA3/COX7B/PLCB1/MAPK8/NDUFA9/NDUFB4/VDAC1/GSR/NDUFB6/COX6B1/MT-CO2/COX7A2/PIK3CB/UQCRQ/SDHB/NDUFB8/SLC2A1/PDK3/UQCR11/SP1/COX6A1/GAPDH/COX6A2/UQCR10/CAMK2D/MT-ND4/RELA/PLCB2/ATP5PF/NDUFC2/NCF1/NDUFA13	3.22492441623313
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	37/2062	105/9376	1.60229088725694	ZAP70/SYK/CARD11/PLCG2/TRAF5/CYLD/BCL2/NFKB1/TAB2/MALT1/PARP1/TRAF6/RIPK1/RELB/CSNK2B/ICAM1/UBE2I/CSNK2A1/BIRC3/BCL2L1/MAP3K7/IRAK4/IKBKB/BIRC2/CHUK/IRAK1/TNFSF14/NFKB2/LAT/TRAF2/RELA/LYN/TNFAIP3/CCL21/MAP3K14/TAB1/TNFSF13B	3.29526345474373
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	29/2062	77/9376	1.71252220136798	RAC2/ARHGEF6/CDK6/CDKN2A/MAPK1/KRAS/TGFBR1/TGFB1/MAP2K1/NFKB1/RALBP1/E2F3/PIK3CD/SMAD4/PLD1/BRCA2/BAX/BRAF/DDB2/TP53/BCL2L1/MAPK8/RPS6KB2/IKBKB/CHUK/PIK3CB/RAD51/RELA/JAK1	3.33332861401943
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	29/2062	77/9376	1.71252220136798	CDK6/CDKN2A/MAPK1/KRAS/TGFBR1/TGFB1/MAP2K1/NFKB1/CTBP2/BCR/RUNX1/E2F3/PIK3CD/CBL/SMAD4/HDAC2/SOS1/BAX/BRAF/DDB2/TP53/BCL2L1/CRK/IKBKB/MDM2/CHUK/PIK3CB/CRKL/RELA	3.33332861401943
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	35/2062	98/9376	1.62394346681447	PTPRC/RAC2/ARPC5L/VAV3/SYK/PLCG2/MAPK1/ACTR2/MAP2K1/INPP5D/ARPC1B/WAS/VASP/PIK3CD/ARF6/PLD1/DNM2/LIMK1/ACTR3/CRK/ASAP1/RPS6KB2/PLA2G6/ARPC2/VAV1/ARPC4/PIK3CB/CFL1/ARPC3/LAT/CRKL/LYN/PAK1/NCF1/INPPL1	3.29673156316234
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	15/2062	32/9376	2.13142580019399	CASP3/BCL2/BCL2L11/BIRC6/CASP8/PMAIP1/CYCS/BID/BIRC5/BAX/BIRC3/BCL2L1/MAPK8/BIRC2/APAF1	3.40398112130615
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	42/2062	125/9376	1.52780601357905	RAC2/SGMS1/CTSD/MAPK1/KRAS/PPP2R2A/MAP2K1/BCL2/PPP2R5A/FCER1G/NFKB1/GNA13/FYN/PIK3CD/PPP2R1B/S1PR4/MAPK14/PLD1/PPP2R5E/PPP2R5C/ORMDL2/BID/BAX/ROCK1/TP53/ABCC1/PLCB1/MAPK8/PPP2R3C/PPP2R2B/NSMAF/PPP2CA/GNAI2/PIK3CB/CERS6/GNAI3/TRAF2/ORMDL3/GNAQ/RHOA/RELA/PLCB2	3.15418738713482
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	32/2062	90/9376	1.61672594029529	ZAP70/EML4/PPP3CC/MAPK1/CD247/KRAS/MAP2K1/PTPN6/NFKB1/PPP3CA/NFATC2/CD3E/PIK3CD/NFKBIB/PPP3R1/NFATC3/MAPK14/RASGRP1/TRAF6/JAK2/CSNK2B/CSNK2A1/MAP2K3/RPS6KB2/IKBKB/CHUK/PIK3CB/LAT/MAP3K3/RELA/JAK1/NFKBIE	3.12141577966172
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	31/2062	87/9376	1.62021026344248	RAC2/CASP3/MAPK1/KRAS/AREG/TGFBR1/TGFB1/GSK3B/MAP2K1/BCL2/BCL2L11/MSH3/PIK3CD/PMAIP1/SMAD4/LEF1/SOS1/CYCS/BIRC5/MSH2/BAX/BRAF/DDB2/TP53/MAPK8/RPS6KB2/PIK3CB/MLH1/RHOA/AXIN1/CTNNB1	3.08579154216813
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	46/2062	142/9376	1.4729853417303	TYROBP/LCP2/SYK/PLCG2/PPP3CC/MAPK1/ITPR1/CYLD/TGFBR1/TGFB1/MAP2K1/CSF1/NFKB1/PPP3CA/TAB2/FYN/NFATC2/PIK3CD/SOCS1/PPP3R1/MAPK14/CREB1/IRF9/IFNAR2/TRAF6/RELB/ACP5/MAP3K7/MAPK8/TEC1/FOSL2/IKBKB/CHUK/PIK3CB/MAP2K7/TYK2/NFKB2/ITPR3/JUND/TRAF2/TMEM64/RELA/JAK1/NCF1/MAP3K14/TAB1	3.01543109884845
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	80/2062	275/9376	1.32277576933251	RAC2/NCAM1/CASP3/SLC25A5/TUBA1B/PPP3CC/MAPK1/NDUFB3/ITPR1/NDUFV1/PRKACB/GSK3B/NDUFA7/STIP1/NDUFS7/NDUFS8/NDUFS6/PPP3CA/FYN/PIK3CD/NDUFAB1/UQCRC2/VDAC3/PPP3R1/NDUFB9/MAPK14/CREB1/COX8A/COX5A/KLC1/CYCS/PSMD14/CSNK2B/ADRM1/PSMA5/PSMD1/CSNK2A1/BAX/NDUFA3/PSMA3/COX7B/PSMA4/MAPK8/NDUFA9/NDUFB4/VDAC1/TUBA4A/HSPA1B/TUBB/ATF2/NDUFB6/COX6B1/PSMD7/PSMD4/MT-CO2/COX7A2/EIF2AK3/TUBA1C/PSMA6/HSPA8/PSMB3/PIK3CB/UQCRQ/SDHB/NDUFB8/APAF1/TUBB4B/ATF6B/UQCR11/COX6A1/ITPR3/COX6A2/NOTCH1/UQCR10/MT-ND4/ATP5PF/NDUFC2/NCF1/KLC2/NDUFA13	2.88453096456246
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	108/2062	388/9376	1.26567140300179	CASP3/SLC25A5/TUBA1B/PPP3CC/MAPK1/KRAS/NDUFB3/ITPR1/NDUFV1/APH1B/GSK3B/MAP2K1/NDUFA7/CSF1/NDUFS7/NFKB1/NDUFS8/EIF2AK2/NDUFS6/PPP3CA/SLC39A11/PIK3CD/NDUFAB1/UQCRC2/VDAC3/PPP3R1/CASP8/WNT6/NDUFB9/CALM3/COX8A/COX5A/SLC39A4/SLC39A8/KLC1/CYCS/PSMD14/CSNK2B/ADRM1/BID/PSMA5/PSMD1/SLC39A9/CSNK2A1/BRAF/ADAM10/ATF6/ATG101/NDUFA3/CSNK1E/PSMA3/COX7B/PSMA4/PLCB1/MAPK8/NDUFA9/NDUFB4/VDAC1/TUBA4A/PSENEN/TUBB/IKBKB/NDUFB6/NAE1/COX6B1/PSMD7/PPID/PSMD4/MT-CO2/ATG2A/COX7A2/EIF2AK3/TUBA1C/PSMA6/PSMB3/CHUK/CALM1/PIK3CB/UQCRQ/SDHB/NDUFB8/ATG2B/MAP2K7/APAF1/TUBB4B/PIK3R4/APH1A/UQCR11/DVL3/COX6A1/ITPR3/WNT4/GAPDH/COX6A2/TRAF2/UQCR10/GNAQ/MT-ND4/RELA/AXIN1/PLCB2/NCSTN/ATP5PF/NDUFC2/CTNNB1/KLC2/NDUFA13/PSEN2	2.83779899687825
Organismal Systems	Immune system	hsa04611	Platelet activation	41/2062	126/9376	1.47959293643096	LCP2/ARHGEF1/SYK/PLCG2/VAMP8/PPP1CA/MAPK1/ACTB/ITPR1/PRKACB/FERMT3/FCER1G/PIK3R6/PIK3CG/PPP1R12A/GNA13/RAP1A/VASP/FYN/PIK3CD/MAPK14/PPP1CC/STIM1/RASGRP1/ADCY7/ROCK1/PLCB1/GP6/RASGRP2/GNAI2/PIK3CB/TBXAS1/MYL12A/TLN2/GNAI3/ITPR3/ADCY9/GNAQ/RHOA/LYN/PLCB2	2.87766129122166
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	29/2062	83/9376	1.58872541572692	CASP3/SAMHD1/CGAS/NFKB1/POLR2K/TBK1/ADAR/NFKBIB/POLR3GL/CASP8/POLR3K/IRF7/G3BP1/RIPK1/PYCARD/MLKL/IL18/GSDMD/IKBKB/POLR3C/IRF3/ZBP1/CHUK/IFI16/POLR3E/POLR3H/POLR1C/RELA/POLR3B	2.86039725982444
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	14/2062	32/9376	1.98933074684772	RPTOR/ATG10/ATG5/ATG101/ATG4B/ATG7/ATG16L1/GABARAPL1/ATG2A/PPP2CA/ATG2B/PIK3R4/ATG4A/ATG4D	2.97647727709582
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	77/2062	268/9376	1.30642616210895	CASP3/SLC25A5/TUBA1B/NDUFB3/ITPR1/NDUFV1/PRKACB/NDUFA7/NDUFS7/NDUFS8/NDUFS6/UBE2G1/UBE2J1/SLC39A11/NDUFAB1/UQCRC2/VDAC3/NDUFB9/CALM3/COX8A/COX5A/SLC39A4/SLC39A8/KLC1/CAMK2G/CYCS/PSMD14/ADRM1/PSMA5/PSMD1/SLC39A9/BAX/TP53/ATF6/UBE2G2/NDUFA3/BCL2L1/PSMA3/COX7B/PSMA4/MAPK8/NDUFA9/NDUFB4/VDAC1/TUBA4A/TUBB/NDUFB6/COX6B1/PSMD7/PSMD4/MT-CO2/GNAI2/COX7A2/EIF2AK3/TUBA1C/PSMA6/PSMB3/CALM1/UQCRQ/SDHB/NDUFB8/APAF1/TUBB4B/UQCR11/GNAI3/COX6A1/ITPR3/COX6A2/UQCR10/CAMK2D/MT-ND4/ATP5PF/NDUFC2/KEAP1/KLC2/MAOA/NDUFA13	2.70230408989817
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	31/2062	91/9376	1.54899222988457	RAC2/VAV3/SYK/CARD11/PLCG2/PIK3AP1/PPP3CC/MAPK1/KRAS/GSK3B/MAP2K1/INPP5D/PTPN6/NFKB1/PPP3CA/MALT1/NFATC2/PIK3CD/NFKBIB/PPP3R1/NFATC3/SOS1/VAV1/IKBKB/CHUK/PIK3CB/DAPP1/RELA/LYN/NFKBIE/INPPL1	2.79414172392134
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	24/2062	67/9376	1.62879105925272	RPS6KA3/PPP3CC/PPP1CA/MAPK1/KRAS/ITPR1/PRKACB/MAP2K1/EP300/PPP3CA/RAP1A/PPP3R1/CALM3/PPP1CC/CAMK2G/BRAF/PLCB1/CALM1/RPS6KA2/ITPR3/RPS6KA1/GNAQ/CAMK2D/PLCB2	2.74248799228946
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	54/2062	181/9376	1.356575978908	CORO1A/SYK/LSP1/CASP3/PPP3CC/CTSD/MAPK1/KSR1/TGFB1/BCL2/EP300/FCER1G/ITGAX/NFKB1/PPP3CA/ITGAM/MALT1/TCIRG1/PPP3R1/CASP8/CALM3/MAPK14/ATP6V1H/ATP6V0A2/CREB1/TRAF6/JAK2/CAMK2G/NFYC/CYCS/BID/BAX/CASP10/IL18/MAPK8/ATP6V0B/IRAK4/C3/CEBPG/CALM1/IRAK1/ATP6V0C/HSPD1/APAF1/VDR/HSPA9/NOD2/NFYB/CAMK2D/RFXAP/RHOA/RELA/JAK1/RAB5B	2.57198241226743
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	51/2062	170/9376	1.36411251212415	ARPC5L/PATJ/HCLS1/TIAM1/ACTN4/RAPGEF6/EZR/TUBA1B/PPP2R2A/RAB8B/ACTR2/ACTB/PRKACB/PCNA/ARPC1B/WAS/RAP1A/VASP/WHAMM/RUNX1/MAP3K1/PPP2R1B/DLG1/RAB8A/ACTR3/HSPA4/MSN/ROCK1/MAPK8/ARPC2/TUBA4A/SYMPK/PPP2R2B/NF2/PRKAA1/PPP2CA/TUBA1C/ARHGAP17/ARPC4/ARPC3/MYL12A/MAP2K7/AFDN/ARHGEF18/MYH9/MPDZ/F11R/CLDN4/RHOA/PRKAB1/PARD6B	2.54376547778983
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	25/2062	72/9376	1.57883392606962	ISG15/CYLD/RNF125/NFKB1/TBK1/ADAR/NFKBIB/CASP8/MAP3K1/MAPK14/IRF7/TRAF6/RIPK1/PIN1/ATG5/CASP10/MAP3K7/MAPK8/IKBKB/IRF3/CHUK/IFIH1/TRAF2/TKFC/RELA	2.6178084527293
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	35/2062	109/9376	1.46005926374145	ZAP70/IL2RB/IL2RG/PPP3CC/MAPK1/CD247/GATA3/TGFBR1/TGFB1/NFKB1/PPP3CA/RUNX1/NFATC2/CD3E/NFKBIB/PPP3R1/NFATC3/MAPK14/SMAD4/JAK2/RXRA/JAK3/MAPK8/IL21R/IKBKB/CHUK/IL27RA/AHR/TYK2/LAT/IL4R/RELA/JAK1/NFKBIE/IL12RB1	2.56513329747111
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	38/2062	122/9376	1.41629167925458	KAT2B/PLCG2/MAPK1/KRAS/ATP1B3/ACTB/PRKACB/GSK3B/MAP2K1/NCOA1/EP300/MED14/PIK3CD/ATP1B1/NCOA2/TBC1D4/MED17/MED27/HDAC2/NCOA3/NOTCH2/RXRA/PFKP/TP53/NCOR1/MED30/SIN3A/PLCB1/MED1/ATP1A1/MDM2/PIK3CB/SLC2A1/HDAC3/WNT4/NOTCH1/PLCB2/CTNNB1	2.45734078517831
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	66/2062	232/9376	1.29355496839359	IQGAP2/ITGAD/RAC2/ARPC5L/VAV3/TIAM1/ARHGEF1/ARHGEF6/PIP4K2A/ACTN4/EZR/CYFIP2/DIAPH1/SSH2/PPP1CA/MAPK1/KRAS/ARHGEF7/ACTR2/ACTB/SPATA13/MAP2K1/DIAPH3/PFN1/ARPC1B/ITGAX/PPP1R12A/GNA13/ITGAL/NCKAP1L/FGD3/ITGAM/RRAS2/PIK3CD/ITGA1/IQGAP1/PPP1CC/SSH1/LIMK1/ACTR3/SOS1/RGCC/MSN/ROCK1/BRAF/PIKFYVE/CRK/ARPC2/ITGA4/VAV1/ITGAE/PPP1R12B/ARPC4/PIK3CB/CFL1/ARPC3/MYL12A/PXN/ITGB7/MYH9/ITGA3/CRKL/RHOA/PAK4/PAK1/GIT1	2.40390781645609
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	7/2062	13/9376	2.44840707304335	XRCC4/MRE11/PRKDC/FEN1/XRCC5/DCLRE1C/NHEJ1	2.77464414755789
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	42/2062	138/9376	1.38388225867668	NDUFB3/NDUFV1/NDUFA7/NDUFS7/NDUFS8/NDUFS6/NDUFAB1/TCIRG1/UQCRC2/NDUFB9/ATP6V1H/ATP6V0A2/COX8A/COX5A/CYCS/PPA2/NDUFA3/COX7B/NDUFA9/NDUFB4/ATP6V0B/COX17/NDUFB6/COX6B1/ATP5MG/MT-CO2/COX7A2/ATP5MF/UQCRQ/ATP6V0C/SDHB/NDUFB8/COX10/UQCR11/COX6A1/COX6A2/UQCR10/MT-ND4/ATP6V1B2/ATP5PF/NDUFC2/NDUFA13	2.41213214535492
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	36/2062	115/9376	1.42342175178172	STK39/ARHGEF1/PDE4A/MAPK1/MEF2A/ITPR1/GATA3/PRKACB/MAP2K1/BCL2/BGLAP/GNA13/OXSR1/CREB1/PLD1/MEF2D/ADCY7/PDE4B/RXRA/BRAF/NR4A2/PLCB1/ATF2/GNAI2/VDR/ATF6B/GNAI3/SP1/ITPR3/ADCY9/JUND/GNAQ/RHOA/PLCB2/ARRB2/PDE4D	2.42574772827766
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	26/2062	78/9376	1.51568056902683	ARPC5L/SEPTIN6/HCLS1/ACTR2/ACTB/ARPC1B/PIK3CD/CBL/SEPTIN9/DNM2/ACTR3/MAD2L2/ELMO1/ILK/CRK/ARPC2/CD2AP/ARHGAP10/ARPC4/PIK3CB/ARPC3/PXN/ELMO2/CRKL/RHOA/CTNNB1	2.42820745696208
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	70/2062	250/9376	1.27317167798254	OSBPL3/CTSW/WDR7/SLC15A4/VAMP8/GNPTAB/CTSD/AP3B1/AP1S3/BORCS5/MANBA/GGA2/RPTOR/VPS13A/CD164/TCIRG1/IGF2R/FUCA1/AP1S2/VPS26A/VPS41/IDS/ATP6V1H/ATP6V0A2/CLN3/VPS29/VPS13C/LITAF/KXD1/GUSB/PIKFYVE/AP3M1/ACP5/CTSA/CLN6/ATP6V0B/AP1B1/GALC/OSTM1/AP1M1/BLOC1S2/AP3D1/SPG11/OSBPL7/ARSB/LAMTOR4/ATP6V0C/SORT1/DTNBP1/TPP1/AP1G2/BORCS8/NEU1/GPR155/HEXB/MFSD8/CD68/ATP6V1B2/SLC29A1/CLN8/AP5B1/AP4S1/AP4B1/TTI1/CLCN7/OSBPL2/AGA/NPC1/TFEB/AP3M2	2.32443782051712
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	36/2062	116/9376	1.41115087461119	MMP9/RAC2/VAV3/ITK/TXK/ACTN4/PLCG2/PTK2B/EZR/ACTB/RHOH/ITGAL/RAP1A/VASP/ITGAM/RASSF5/PIK3CD/MAPK14/PECAM1/ICAM1/MSN/ROCK1/ITGA4/VAV1/GNAI2/SIPA1/PIK3CB/MYL12A/PXN/AFDN/GNAI3/F11R/CLDN4/RHOA/NCF1/CTNNB1	2.36579554903674
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	12/2062	30/9376	1.8188166828322	NFKB1/TYMS/DHFR/FPGS/ABCC1/GART/IKBKB/CHUK/SHMT1/ABCC4/SHMT2/RELA	2.3849919209338
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	32/2062	103/9376	1.41267315171433	MAP2K4/MAPK1/CD247/PPP2R2A/TGFBR1/TGFB1/NFKB1/CD3E/PIK3CD/CASP8/PPP2R1B/FASLG/MAPK14/TRAF6/PLCB1/MAPK8/GNA15/IRAK4/IKBKB/PPP2R2B/C3/PPP2CA/GNAI2/CCL3/CHUK/PIK3CB/IRAK1/SERPINE1/GNAI3/GNAQ/RELA/PLCB2	2.23597625877879
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	41/2062	138/9376	1.35093268108914	PPP1CA/MAPK1/KRAS/PTPN1/PRKACB/GSK3B/MAP2K1/RPTOR/RAPGEF1/EIF4E/PIK3CD/INPP5A/SOCS1/CBL/CALM3/PPP1CC/SOS1/BRAF/SOCS4/PHKB/CRK/PRKAR2A/MAPK8/ACACA/RPS6KB2/PHKG2/IKBKB/EIF4EBP1/PRKAA1/PRKAR2B/CALM1/PIK3CB/PYGB/HKDC1/PHKA2/PRKAR1B/CRKL/FLOT2/PRKAB1/SORBS1/INPPL1	2.20509279024445
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	21/2062	62/9376	1.54012702981759	MAML3/KAT2B/APH1B/EP300/CTBP2/ITCH/SPEN/HDAC2/MAML1/SNW1/NOTCH2/DTX3L/TLE3/PSENEN/RBPJ/LFNG/APH1A/DVL3/NOTCH1/NCSTN/PSEN2	2.26556293033327
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	34/2062	112/9376	1.3803519467923	CASP3/LDLR/MAPK1/TGFB1/BCL2/PIK3R6/NFKB1/PIK3CG/TAB2/SOCS1/NFKBIB/CASP8/MAPK14/TRAF6/JAK2/CYCS/MAP2K3/BIRC3/BCL2L1/MAP3K7/MAPK8/HSPA1B/IRAK4/IKBKB/BIRC2/GNAI2/HSPA8/CHUK/IRAK1/TYK2/GNAI3/RELA/JAK1/TAB1	2.15004659708093
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	19/2062	56/9376	1.54274629347374	CUL1/GRK2/PRKACB/GSK3B/BCL2/CSNK1G1/CCND2/MOSMO/SPOP/MGRN1/CSNK1G3/CSNK1E/CUL3/CSNK1G2/SMURF2/SMURF1/SUFU/ARRB2/KIF7	2.16289488833209
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	23/2062	71/9376	1.4729853417303	PLCG2/CASP3/MAP2K4/CSK/NFKB1/TCIRG1/MAPK14/ATP6V1H/ATP6V0A2/ADAM10/MAPK8/ATP6V0B/IKBKB/CHUK/ATP6V0C/F11R/ATP6V1B2/RELA/LYN/PAK1/NOD1/GIT1/MAP3K14	2.12408141020266
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	17/2062	49/9376	1.57754508204834	GALNT1/GALNT2/ST3GAL3/B4GALT1/GALNT10/OGT/GXYLT1/GALNT11/GALNT7/GALNT6/LFNG/XXYLT1/B4GALT3/B3GLCT/EOGT/GALNT4/GALNT3	2.15211479131255
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	39/2062	133/9376	1.33334305696346	STK4/MAPK1/KRAS/TGFBR1/TGFB1/MAP2K1/EP300/BCL2L11/PIK3CD/CCND2/S1PR4/FASLG/MAPK14/TNFSF10/SMAD4/CCNB1/SOS1/KLF2/BRAF/RBL2/CSNK1E/AGAP2/MAPK8/CDKN2D/IKBKB/NLK/GABARAPL1/PRKAA1/DEPP1/MDM2/CHUK/PIK3CB/PLK1/CCNB2/FOXO3/PLK4/HOMER2/CDK2/PRKAB1	2.05571662673101
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	48/2062	169/9376	1.29146746709979	VAMP8/CTSD/MAPK1/KRAS/ITPR1/PRKACB/MAP2K1/BCL2/RPTOR/TBK1/BIRC6/DAPK2/RRAS2/PIK3CD/VPS41/RAB8A/GORASP2/TRAF6/EPG5/ATG10/ATG5/DDIT4/MTMR3/HMGB1/ATG101/ATG4B/BCL2L1/ATG7/MAP3K7/MAPK8/ATG16L1/RPS6KB2/GABARAPL1/UVRAG/PRKAA1/ATG2A/PPP2CA/EIF2AK3/ATG16L2/RUBCN/PIK3CB/MTMR14/ATG2B/PIK3R4/SUPT20H/ATG4A/ATG4D/MTMR4	2.0301440672096
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	11/2062	28/9376	1.78633781349591	TECR/ELOVL5/ACOT7/ELOVL1/HACD1/HACD4/HACD2/HADH/HACD3/ELOVL6/THEM4	2.21248999286014
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	88/2062	333/9376	1.20162063130055	MAML3/PATJ/ISG15/CDK6/CASP3/CCND3/MAPK1/KRAS/MX1/PPP2R2A/OASL/PRKACB/GSK3B/MAP2K1/PPP2R5A/EP300/NFKB1/EIF2AK2/HES6/TBK1/PIK3CD/TCIRG1/ITGA1/CASP8/WNT6/CCND2/PPP2R1B/RBL1/DLG1/FASLG/ATP6V1H/ATP6V0A2/CREB1/IRF9/PPP2R5E/BCAP31/IFNAR2/PPP2R5C/HDAC2/SOS1/MAML1/ATR/HLA-F/IRF1/NOTCH2/BAX/RBL2/UBR4/TP53/UBE3A/TBPL1/RPS6KB2/CCNA2/ATP6V0B/PPP2R3C/ITGA4/IKBKB/PPP2R2B/RBPJ/EIF4EBP1/PPP2CA/MDM2/IRF3/LFNG/CHUK/PIK3CB/ATP6V0C/PTGER4/PXN/ITGB7/HLA-E/TYK2/TBP/DVL3/WNT4/ITGA3/NOTCH1/CDK2/CCNE2/ATP6V1B2/RELA/JAK1/AXIN1/CTNNB1/THBS1/VTN/HLA-A/PARD6B	1.98908486225768
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	22/2062	68/9376	1.47110172876134	MAPK1/KRAS/MAP2K1/NFKB1/ITGAM/RUNX1/PIK3CD/DUSP6/PIM1/LEF1/SOS1/BRAF/PER2/RPS6KB2/CCNA2/IKBKB/PML/EIF4EBP1/CHUK/PIK3CB/RELA/PIM2	2.07011016377117
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	16/2062	46/9376	1.58157972420191	PSME2/PSMB8/PSME4/PSMD14/ADRM1/PSMA5/PSMD1/PSMA3/PSMA4/PSMD7/PSMB9/PSME3/PSMF1/PSMD4/PSMA6/PSMB3	2.09942247332733
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	22/2062	69/9376	1.44978141385175	RAC2/VAV3/LCP2/SYK/PLCG2/MAP2K4/MAPK1/KRAS/MAP2K1/INPP5D/FCER1G/FYN/PIK3CD/MAPK14/SOS1/MAP2K3/MAPK8/VAV1/PIK3CB/MAP2K7/LAT/LYN	1.99101111429007
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	13/2062	36/9376	1.6419872831124	B4GALT5/GALNT1/GALNT2/ST3GAL1/GALNT10/GCNT1/ST6GALNAC3/GALNT11/GALNT7/GALNT6/GALNT4/GALNT3/ST3GAL2	2.0490696856023
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	31/2062	104/9376	1.355368201149	CHKA/SGMS1/LPIN1/DGKZ/GPD2/DGKE/LYPLA1/LCLAT1/DGKD/SELENOI/ETNK1/AGPAT5/PLD1/PLAAT3/AGPAT4/CDS2/PLA2G6/LYPLA2/PISD/GPCPD1/PTDSS1/LPCAT1/CRLS1/CEPT1/DGKQ/GNPAT/PNPLA6/GPAT4/DGKB/PCYT2/GPD1L	1.93491108541557
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	41/2062	144/9376	1.29464381937709	SLC25A5/PUM2/ITPR1/ATXN10/ATXN2L/NOP56/PIK3CD/VDAC3/AFG3L2/CYCS/PSMD14/ADRM1/PSMA5/PSMD1/OPA1/ATG101/GTF2B/PSMA3/PSMA4/PLCB1/MAPK8/TBPL1/VDAC1/PSMD7/RBPJ/PUM1/PSMD4/ATG2A/PSMA6/PSMB3/PIK3CB/ATG2B/PIK3R4/TBP/SP1/ITPR3/TRAF2/GNAQ/PLCB2/DAB1/KAT5	1.89183464466321
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	28/2062	93/9376	1.3690018042823	CDK6/CKS2/CASP3/TRAF5/BCL2/NFKB1/CKS1B/E2F3/PIK3CD/TRAF6/CYCS/RXRA/BAX/DDB2/TP53/BIRC3/BCL2L1/IKBKB/BIRC2/CHUK/PIK3CB/APAF1/ITGA3/CDK2/TRAF2/CCNE2/RELA/ZBTB17	1.8987958743585
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	15/2062	44/9376	1.55012785468654	MNAT1/TAF15/GTF2F2/CCNH/TAF3/TAF2/GTF2B/TBPL1/TAF5L/GTF2F1/ERCC3/GTF2H1/TAF1/TBP/TAF4	1.94202626411164
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/2062	23/9376	1.77927718972715	IDI1/HMGCS1/PDSS2/ACAT2/FDPS/DHDDS/PDSS1/ZMPSTE24/RCE1	1.98670280828156
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/2062	56/9376	1.46154912013302	CASP3/NFKB1/ITGAM/HSF1/RAB1B/CASP8/PYCARD/CYCS/HBS1L/IL18/HSPA1B/C3/SAR1B/HSPA8/HSPD1/APAF1/NFKB2/RELA	1.83931653638862
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	78/2062	300/9376	1.18223084384093	RASA2/RAC2/PTPN7/MAP3K8/STMN1/RPS6KA5/RPS6KA3/STK4/CASP3/MAP2K4/PPP3CC/DUSP10/MAPK1/KRAS/AREG/TGFBR1/PRKACB/TGFB1/MAP2K1/CSF1/NFKB1/PPM1B/DUSP5/TAOK3/PPP3CA/RAP1A/TAB2/RRAS2/PPP3R1/MAP3K1/NFATC3/FASLG/DUSP2/MAPK14/DUSP6/RASGRP1/NR4A1/TRAF6/SOS1/RELB/BRAF/TP53/MAP2K3/CDC25B/CRK/MAP3K7/MAPK8/HSPA1B/IRAK4/MAP4K3/ATF2/IKBKB/NLK/RASGRP2/ELK4/MAP3K2/HSPA8/CHUK/RPS6KA2/IRAK1/MAP2K7/MAPKAPK5/PPP5C/NFKB2/MAP3K21/RPS6KA1/JUND/MAP3K11/CRKL/TRAF2/MAP3K9/MAP3K3/RELA/PAK1/TAOK2/MAP3K14/ARRB2/TAB1	1.70328672110583
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	33/2062	116/9376	1.29355496839359	IDH2/PGP/SUCLG2/ACAT2/G6PD/CS/ADPGK/HIBCH/ME2/PGK1/PFKP/ENO1/GLUD1/OGDH/PGD/IDH3B/MDH2/MDH1/RPIA/SHMT1/SDHB/HKDC1/SHMT2/GOT2/GAPDH/ACSS1/ACADS/TKFC/PRPS1/DLAT/TPI1/GOT1/IDH1	1.68913914698572
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	37/2062	133/9376	1.26496648993969	PPP3CC/PPP1CA/PPP2R2A/ITPR1/PRKACB/GSK3B/PPP2R5A/PPP3CA/PPP2R1B/CALM3/MAPK14/PPP1CC/CREB1/PPP2R5E/PPP2R5C/CAMK2G/GNGT2/PLCB1/MAPK8/PPP2R3C/ATF2/PPP2R2B/GSK3A/PPP2CA/GNAI2/CALM1/GNB1/ATF6B/GNB5/GNAI3/ITPR3/GNAQ/CAMK2D/GNG5/PLCB2/MAOA/ARRB2	1.63404039027364
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	31/2062	109/9376	1.29319534788528	MAP3K8/MAP2K4/MAPK1/MAP2K1/NFKB1/TAB2/TBK1/PIK3CD/CASP8/MAPK14/IRF9/IRF7/IFNAR2/TRAF6/RIPK1/MAP2K3/MAP3K7/MAPK8/IRAK4/IKBKB/IRF3/CCL3/CHUK/PIK3CB/IRAK1/MAP2K7/TYK2/RELA/JAK1/IRF5/TAB1	1.63475710369965
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	10/2062	28/9376	1.62394346681447	GCH1/DHFR/FPGS/AKR1B1/PTS/PCBD2/MOCS2/PCBD1/GPHN/QDPR	1.75556694940074
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	21/2062	70/9376	1.36411251212415	MAPK1/KRAS/ETS1/TGFB1/MAP2K1/EP300/EPAS1/RAP1A/RAPGEF1/PIK3CD/SOS1/RBX1/BRAF/CUL2/CRK/PRCC/PIK3CB/SLC2A1/CRKL/PAK4/PAK1	1.62351232362966
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	24/2062	82/9376	1.33084147524307	KLRC3/KLRC1/KLRC2/KLRC4/KIR2DL4/KLRD1/TAPBP/CREB1/PSME2/NFYC/HLA-F/HSPA4/KIR2DL3/HSPA1B/TAP1/PSME3/TAP2/HSPA8/KIR2DL1/HLA-E/NFYB/KIR3DL1/RFXAP/HLA-A	1.59763671160523
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	26/2062	90/9376	1.31358982648992	KRAS/PRKACB/NFKB1/RPTOR/EIF4E/ADIPOR2/PIK3CD/SESN1/CREB1/ADCY7/EHMT1/ATG5/BAX/TP53/ATG101/RPS6KB2/ADIPOR1/ATF2/EIF4EBP1/PRKAA1/PIK3CB/ATF6B/FOXO3/ADCY9/RELA/PRKAB1	1.58716241492673
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	42/2062	155/9376	1.23210162385407	CDK6/LDLR/CDKN2A/MAPK1/ITPR1/PRKACB/GSK3B/MAP2K1/RAP1A/E2F3/WNT6/CREB1/ADCY7/NR4A1/LEF1/CAMK2G/BRAF/KMT2A/ARMC5/PLCB1/ATF2/GNAI2/ASH2L/RBBP5/NCEH1/KMT2D/ATF6B/AHR/GNAI3/SP1/DVL3/ITPR3/ADCY9/WNT4/CDK2/WDR5/GNAQ/CCNE2/CAMK2D/AXIN1/PLCB2/CTNNB1	1.54706124784173
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	7/2062	18/9376	1.76829399719797	MANBA/FUCA1/HEXD/NEU1/HEXB/AGA/NEU3	1.73230621212519
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	59/2062	227/9376	1.18183022342621	PRKD3/SLC25A5/MAP2K4/MAPK1/KRAS/NDUFB3/PTPN1/NDUFV1/MAP2K1/NDUFA7/PRKD2/NDUFS7/NFKB1/NDUFS8/NDUFS6/PIK3CD/NDUFAB1/UQCRC2/VDAC3/MGST2/NDUFB9/MAPK14/COX8A/PLD1/COX5A/SOS1/BRAF/PTPRJ/NDUFA3/COX7B/MAPK8/NDUFA9/NDUFB4/VDAC1/IKBKB/NDUFB6/COX6B1/MT-CO2/COX7A2/CHUK/PIK3CB/UQCRQ/SDHB/NDUFB8/MAP2K7/AHR/FOXO3/UQCR11/COX6A1/COX6A2/UQCR10/MT-ND4/RELA/ATP5PF/NDUFC2/KEAP1/NCF1/MAP3K14/NDUFA13	1.47246397370077
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	118/2062	480/9376	1.11781441965729	CASP3/SLC25A5/TUBA1B/PPP3CC/MAPK1/KRAS/NDUFB3/ITPR1/NDUFV1/GSK3B/MAP2K1/NDUFA7/BCL2/CSF1/NDUFS7/NFKB1/NDUFS8/ATXN2L/NDUFS6/PPP3CA/HIP1/UBE2G1/TBK1/UBE2J1/NDUFAB1/UQCRC2/VDAC3/PPP3R1/CASP8/WNT6/NDUFB9/FASLG/CALM3/MAPK14/RAB8A/FUS/COX8A/COX5A/KLC1/CAMK2G/CYCS/PSMD14/CSNK2B/ADRM1/HTT/BID/PSMA5/PSMD1/DCTN4/CSNK2A1/BAX/BRAF/MAP2K3/ATF6/ATG101/TOMM40/UBE2G2/NDUFA3/BCL2L1/CSNK1E/PSMA3/TNFRSF1B/COX7B/PSMA4/PLCB1/MAPK8/TARDBP/NDUFA9/NDUFB4/VDAC1/TUBA4A/TUBB/NDUFB6/COX6B1/PSMD7/PPID/PSMD4/MT-CO2/ATG2A/SPG11/COX7A2/EIF2AK3/TUBA1C/PSMA6/PSMB3/CALM1/UQCRQ/SDHB/DNAH14/NDUFB8/DCTN5/ATG2B/MAP2K7/APAF1/TUBB4B/PIK3R4/UQCR11/DVL3/COX6A1/ITPR3/WNT4/SIGMAR1/COX6A2/TRAF2/UQCR10/GNAQ/VAPB/CAMK2D/MT-ND4/RELA/AXIN1/PLCB2/ATP5PF/NDUFC2/CTNNB1/KLC2/NDUFA13/PSEN2	1.40693544357575
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/2062	15/9376	1.8188166828322	ST3GAL1/SLC33A1/ST6GALNAC3/HEXB/ST3GAL5/ST3GAL2	1.68509224573598
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	12/2062	37/9376	1.47471622932341	MAPK1/KRAS/MAP2K1/TPM3/LEF1/RXRA/BAX/BRAF/DDB2/TP53/TPR/CTNNB1	1.53616280154875
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	13/2062	41/9376	1.44174493151333	MMP9/RPS6KA5/CDKN2A/MAPK1/KRAS/RASSF1/MAP2K1/DAPK2/E2F3/BRAF/TP53/MDM2/THBS1	1.5050773951315
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	10/2062	30/9376	1.51568056902683	IDH2/SUCLG2/CS/OGDH/IDH3B/MDH2/MDH1/SDHB/DLAT/IDH1	1.50203826655982
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	26/2062	93/9376	1.27121596111928	PTK2B/MAP2K4/MAPK1/KRAS/ITPR1/PRKACB/MAP2K1/MAP3K1/CALM3/MAPK14/PLD1/ADCY7/SOS1/CAMK2G/MAP2K3/PLCB1/MAPK8/MAP3K2/CALM1/MAP2K7/ITPR3/ADCY9/GNAQ/CAMK2D/MAP3K3/PLCB2	1.39561308930479
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	21/2062	73/9376	1.30805309381768	EML4/CDK6/PLCG2/STK4/CDKN2A/MAPK1/KRAS/RASSF1/MAP2K1/RASSF5/E2F3/PIK3CD/SOS1/RXRA/BAX/BRAF/DDB2/TP53/JAK3/PIK3CB/FOXO3	1.40290410203037
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	52/2062	201/9376	1.17634909834919	FLI1/MMP9/NSD2/IL2RB/TAF15/CCNT1/EWSR1/NR4A3/GZMB/ID2/NFKB1/CCNT2/FUT8/ITGAM/RUNX1/REL/CCND2/DUSP6/FUS/HDAC2/RXRA/BAX/DDB2/KMT2A/TP53/NCOR1/DOT1L/PER2/BIRC3/BCL2L1/SIN3A/CCNA2/PRCC/KDM6A/PBX3/ETV6/BIRC2/PML/IGFBP3/ELK4/MDM2/MLLT3/ITGB7/SUPT3H/SS18L1/ATF1/SP1/IL1R2/SIX4/RELA/TCF3/ZBTB17	1.34190177216118
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/2062	34/9376	1.47110172876134	CUL1/BHLHE40/CREB1/RBX1/PER2/CSNK1E/PER1/PRKAA1/CRY2/PRKAB1/NR1D1	1.46112279301415
NA	NA	hsa04517	IgSF CAM signaling	75/2062	299/9376	1.14056230110715	CABLES1/CD96/NCAM1/ARPC5L/VAV3/LCP2/ACTN4/DOK2/MBP/RAPGEF6/PLCG2/EZR/TUBA1B/SRGAP3/CASK/MAPK1/ACTR2/ACTB/LMO7/CSK/GSK3B/MAP2K1/INPP5D/PTPN6/ARPC1B/ITGAX/ITGAL/RAP1A/SH2D1B/ITGAM/FYN/PIK3CD/ARF6/MAPK14/IQGAP1/ICAM3/TRAF6/ACTR3/ICAM1/MSN/NCK1/MAPK8/CRTAM/SRGAP2/ARPC2/NECTIN3/TUBA4A/ITGA4/VAV1/CD2AP/TUBB/CD2/TUBA1C/ARPC4/PIK3CB/ARPC3/MYL12A/PXN/TUBB4B/NFASC/AFDN/MYH9/MPDZ/F11R/RHOA/PAK4/LYN/CD48/PAK1/CABLES2/UNC5B/CTNNB1/SORBS1/GIT1/PARD6B	1.3115527892242
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	30/2062	110/9376	1.24010228374923	CUL1/TFDP1/MAPK1/TGFBR1/SKI/ID3/TGFB1/EP300/ID2/PPP2R1B/RBL1/SMAD4/HDAC2/LEMD3/RBX1/TFRC/ROCK1/NCOR1/SMAD7/SIN3A/RPS6KB2/PPP2CA/ID1/TGIF2/SMURF2/SMURF1/SP1/RHOA/E2F5/THBS1	1.34492781722028
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	22/2062	78/9376	1.28249894302271	CASP3/IRF8/MAPK1/NFKB1/ITGAM/CALM3/MAPK14/TRAF6/PYCARD/IRF1/MAPK8/IRAK4/C3/GNAI2/IRF3/CALM1/CFL1/IRAK1/GNAI3/RHOA/RELA/NOD1	1.3302150230833
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/2062	27/9376	1.51568056902683	TECR/ELOVL5/ACOT7/ELOVL1/HACD1/HACD4/HACD2/HACD3/ELOVL6	1.42472997073531
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	37/2062	140/9376	1.2017181654427	MAPK1/KRAS/MEF2A/ITPR1/TGFBR1/PRKACB/MAP2K1/PIK3R6/PIK3CG/GNA13/NRF1/RRAS2/CALM3/SMAD4/MEF2D/ADCY7/KLF2/GNGT2/PLCB1/RPS6KB2/PRKAA1/GNAI2/CALM1/TFAM/HDAC5/PIK3R4/SERPINE1/GNB1/GNB5/GNAI3/PLIN1/ITPR3/ADCY9/GNAQ/GNG5/PLCB2/PRKAB1	1.2767902456926
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	29/2062	107/9376	1.23237578976948	SIK2/PPP4C/PPP3CC/PPP4R3A/ITPR1/PRKACB/EP300/PPP3CA/PPP3R1/CALM3/CREB1/CAMK2G/PPP4R3B/PFKP/PHKB/PLCB1/ACACA/PHKG2/ATF2/PRKAA1/CALM1/SLC2A1/PYGB/ITPR3/PHKA2/GNAQ/CAMK2D/PLCB2/PRKAB1	1.28356781045162
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	41/2062	157/9376	1.18744401267707	ATP11B/CASP3/ATP8A1/XKR6/MAPK1/TGFB1/MAP2K1/PTPN6/VPS8/DUSP5/CD47/NFATC2/ATP11C/VPS41/NFATC3/DUSP2/MAPK14/CREB1/JAK2/PECAM1/CAMK2G/ELMO1/RXRA/ADAM10/RAB14/PTGER2/DNMT3A/CRK/PLA2G6/HAVCR2/ATP11A/PTGER4/SLC2A1/ANO6/CRKL/CAMK2D/ARG1/TGFBRAP1/GULP1/THBS1/RAB5B	1.25756946045815
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	45/2062	174/9376	1.17595906217599	CUL1/STT3B/SEC24B/BCL2/SEC23B/UBE2G1/UBE2J1/UBE2D2/PLAA/BCAP31/NGLY1/RAD23A/RPN1/EDEM1/RBX1/BAX/DNAJB11/ATF6/MOGS/MAGT1/ERO1A/UBE2G2/UGGT1/MAPK8/ERP29/HSPA1B/DNAJC5/MAN1A1/BAG2/SAR1B/EIF2AK3/HSPA8/DNAJC1/SVIP/SEC24D/SEC24C/UBXN4/FBXO6/MAP2K7/ATF6B/HYOU1/DERL3/TRAF2/DNAJB2/UBE2D3	1.24393486090571
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	44/2062	170/9376	1.17688138300907	DPF3/ARID1A/CDK6/PLCG2/SMARCA2/CDKN2A/MAPK1/KRAS/SMARCB1/ACTB/TGFBR1/TGFB1/GSK3B/MAP2K1/BRD7/GSTP1/E2F3/PIK3CD/SMARCC1/WNT6/MGST2/SMAD4/ARID2/LEF1/SOS1/PBRM1/BAX/BRAF/DDB2/TP53/SMARCD1/BCL2L1/RPS6KB2/SMARCD2/SMARCA4/PHF10/ACTL6A/PIK3CB/DVL3/WNT4/ARID1B/AXIN1/KEAP1/CTNNB1	1.23573000317215
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	18/2062	63/9376	1.29915477345157	NSD2/SMYD3/EZH2/GCDH/NSD3/PRDM2/ASH1L/ACAT2/SETD2/KMT2E/EHMT1/KMT2A/KMT5A/DOT1L/KMT2C/HADH/KMT2D/SUV39H2	1.26495157742392
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	17/2062	59/9376	1.31016455966726	MAPK1/KRAS/GSK3B/MAP2K1/PIK3CD/LEF1/SOS1/BAX/BRAF/DDB2/TP53/ILK/PIK3CB/MLH1/FOXO3/AXIN1/CTNNB1	1.26891526299066
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	13/2062	44/9376	1.34344414072833	STT3B/FUT8/ST3GAL3/B4GALT1/RPN1/MAGT1/HEXD/MAN1A1/B4GALNT3/B4GALT3/HEXB/ALG2/MGAT2	1.21240459989018
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	32/2062	122/9376	1.19266667726702	PLCG2/MAP2K4/MAPK1/KRAS/ITPR1/PRKACB/GSK3B/MAP2K1/EP300/PIK3CD/SOCS1/MAP3K1/MAPK14/CREB1/ADCY7/JAK2/SOS1/MAP2K3/CRK/PLCB1/MAPK8/ATF2/IGFBP3/GNAI2/PIK3CB/ATF6B/GNAI3/ITPR3/ADCY9/CRKL/GNAQ/PLCB2	1.13729797540222
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	26/2062	98/9376	1.20635800391932	PRKD3/LDLR/ATP1B3/ITPR1/PRKACB/PRKD2/CALM3/ATP1B1/CREB1/ADCY7/NR4A1/CAMK2G/NR4A2/PLCB1/ATP1A1/ATF2/CALM1/ATF6B/ATF1/DAGLB/ITPR3/ADCY9/GNAQ/CAMK2D/PLCB2/CAMK1D	1.09033427067566
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	40/2062	157/9376	1.15848196358739	PATJ/CCND3/PPP1CA/PPP2R2A/ACTB/AREG/TGFBR1/TGFB1/RASSF1/GSK3B/ID2/WNT6/CCND2/PPP2R1B/DLG1/PPP1CC/SMAD4/YWHAH/LEF1/LATS1/MOB1A/BIRC5/SMAD7/BIRC3/YWHAZ/CSNK1E/PPP2R2B/NF2/BIRC2/NKD1/PPP2CA/ID1/TP53BP2/SERPINE1/DVL3/WNT4/LIMD1/AXIN1/CTNNB1/PARD6B	1.06326190201816
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	10/2062	33/9376	1.37789142638803	IDH2/CS/OGDH/IDH3B/BCKDHB/GOT2/DLAT/GOT1/DBT/IDH1	1.15460471036885
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/2062	33/9376	1.37789142638803	VAMP8/VTI1A/GOSR1/STX2/STX18/STX11/STX3/BNIP1/STX6/VAMP1	1.15460471036885
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	11/2062	37/9376	1.35182321021312	ASL/GFPT1/GLUD1/NIT2/ADSL/GOT2/PPAT/GLS/GOT1/ASRGL1/CAD	1.13848588876171
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	11/2062	37/9376	1.35182321021312	GMDS/GFPT1/GALE/UGP2/HKDC1/PGM1/PGM2/GNPNAT1/FPGT/GALK1/TGDS	1.13848588876171
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	23/2062	86/9376	1.21606929375409	PLCG2/MAP2K4/MAPK1/KRAS/AREG/GSK3B/MAP2K1/PIK3CD/CBL/SOS1/CAMK2G/BRAF/NCK1/CRK/MAPK8/RPS6KB2/EIF4EBP1/PIK3CB/MAP2K7/CRKL/CAMK2D/PAK4/PAK1	1.06877653843877
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	33/2062	128/9376	1.17228419010669	PDE7A/GMPS/PDE4A/NUDT2/RRM2/HPRT1/RRM1/DCK/NT5C2/ADK/ADCY7/NT5C/AK3/PNP/AK2/PDE4B/NME1/NUDT16/GART/AMPD3/PGM1/PGM2/NME7/ADSL/PPAT/ADCY9/CANT1/ENTPD1/PRPS1/AK9/PFAS/IMPDH1/PDE4D	1.0420270443418
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	26/2062	99/9376	1.19417256953629	MMP9/CDKN2A/MAPK1/KRAS/PRKACB/MAP2K1/BCL2/E2F3/PIK3CD/MAPK14/ADCY7/SOS1/NCOA3/NOTCH2/BAX/BRAF/TP53/NCOR1/MAPK8/MED1/RPS6KB2/MDM2/PIK3CB/SP1/ADCY9/NOTCH1	1.03122679125783
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/2062	18/9376	1.51568056902683	LMBRD1/MMADHC/CD320/MMAB/ZNF76/THAP11	1.16272762309146
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/2062	54/9376	1.2630671408557	DNMT1/SMS/MAT2A/MPST/CISD1/KYAT3/DNMT3A/APIP/ENOPH1/MDH2/MDH1/GSS/DNMT3B/GOT2/GOT1	1.02934610611578
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	22/2062	83/9376	1.20523997055146	IDH2/AGPS/PEX14/ACSL3/FAR2/ECI2/FAR1/SLC27A2/ACSL5/PXMP2/HACL1/GNPAT/ACOT8/PEX3/PEX26/PECR/PEX1/PEX6/IDH1/PEX11B/PEX11A/PEX16	0.997184483104004
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	20/2062	75/9376	1.21254445522147	IDH2/MAT2A/ASL/CS/PYCR2/PGK1/PFKP/ENO1/IDH3B/ALDH18A1/RPIA/SHMT1/SHMT2/GOT2/GAPDH/PRPS1/TPI1/GOT1/ARG1/IDH1	0.981223814153168
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	19/2062	71/9376	1.21681397795112	PRL/MAPK1/KRAS/GSK3B/MAP2K1/NFKB1/PIK3CD/SOCS1/CCND2/MAPK14/JAK2/SOS1/IRF1/SOCS4/MAPK8/PIK3CB/FOXO3/RELA/CISH	0.973667679326645
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	52/2062	212/9376	1.11531211683107	RAC2/PRKD3/VAV3/SKAP1/LCP2/TIAM1/FYB1/RAPGEF6/SIPA1L1/MAPK1/KRAS/EVL/ACTB/MAP2K1/PFN1/PRKD2/CSF1/ITGAL/RAP1A/VASP/RAPGEF1/ITGAM/RASSF5/PIK3CD/CALM3/MAPK14/ADCY7/BRAF/MAP2K3/CRK/PLCB1/VAV1/RASGRP2/GNAI2/ID1/SIPA1/CALM1/PIK3CB/LPAR3/TLN2/AFDN/GNAI3/ADCY9/LAT/RGS14/CRKL/GNAQ/RHOA/PLCB2/CTNNB1/THBS1/PARD6B	0.901680807295832
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	44/2062	178/9376	1.12398783770529	CUL1/RAC2/CCDC88C/TBL1XR1/PPP3CC/CCND3/CACYBP/PRKACB/GSK3B/EP300/PPP3CA/CTBP2/NFATC2/PPP3R1/WNT6/CCND2/NFATC3/SMAD4/LEF1/CAMK2G/RBX1/CSNK2B/INVS/CSNK2A1/TP53/LGR4/CSNK1E/TLE3/MAP3K7/PLCB1/MAPK8/RYK/NLK/CHD8/SENP2/NKD1/DVL3/WNT4/CAMK2D/RHOA/AXIN1/PLCB2/CTNNB1/VANGL1	0.88673709217807
Human Diseases	Cancer: specific types	hsa05214	Glioma	20/2062	76/9376	1.19658992291592	CDK6/PLCG2/CDKN2A/MAPK1/KRAS/MAP2K1/E2F3/PIK3CD/CALM3/SOS1/CAMK2G/BAX/BRAF/DDB2/TP53/MDM2/CALM1/PIK3CB/CAMK2D/CAMK1D	0.913648330387126
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	7/2062	23/9376	1.38388225867668	ASL/GLUD1/GOT2/GLS/GOT1/ARG1/CAD	0.978676100643275
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	8/2062	27/9376	1.34727161691274	OXCT1/HMGCS1/ACAT2/AACS/BDH1/HADH/L2HGDH/ACADS	0.959447204952853
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/2062	56/9376	1.21795760011085	MGAT5/STT3B/FUT8/B4GALT1/RPN1/MOGS/MAGT1/DPM2/MAN1A1/ALG6/B4GALT3/DPAGT1/ALG2/MGAT2/SRD5A3	0.868581480558178
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	38/2062	154/9376	1.12199730434454	MTHFD2/GCH1/MAT2A/DHFR/FPGS/CTPS1/AK3/AK2/PDXK/PTS/NME1/GUSB/PANK2/UGP2/UMPS/CMPK1/MOCS2/PPCDC/ALAS1/VKORC1L1/MTHFD1/MMAB/COQ4/SHMT1/HMBS/GSS/COX10/PANK3/NME7/SHMT2/ADSL/NADSYN1/MTHFD2L/GPHN/COQ2/AK9/CAD/CMPK2	0.810495348516112
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	14/2062	52/9376	1.22420353652167	APOA1/STARD3NL/LDLR/APOC2/VDAC3/SOAT1/VDAC1/STARD3/NCEH1/SORT1/APOC1/VAPA/VAPB/NPC1	0.860786582497693
Organismal Systems	Endocrine system	hsa04924	Renin secretion	18/2062	69/9376	1.18618479315144	PPP3CC/ITPR1/PRKACB/PPP3CA/PPP3R1/CALM3/CREB1/REN/PTGER2/PLCB1/GNAI2/CALM1/PTGER4/KCNMA1/GNAI3/ITPR3/GNAQ/PLCB2	0.824169209887552
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	17/2062	65/9376	1.18922629262106	LPIN1/DGKZ/DGKE/LCLAT1/DGKD/AGPAT5/AKR1B1/AGPAT4/PNPLA2/AGK/DGKQ/DGAT1/GK/TKFC/GPAT4/ABHD16A/DGKB	0.812816453544341
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	25/2062	99/9376	1.14824285532336	PRKCH/PLCG2/PPP1CA/ITPR1/PRKACB/PIK3CD/CALM3/MAPK14/PPP1CC/ADCY7/CAMK2G/MAP2K3/PTGER2/PLCB1/MAPK8/PLA2G6/TRPV2/CALM1/PIK3CB/PTGER4/ITPR3/ADCY9/GNAQ/CAMK2D/PLCB2	0.787299691130848
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	41/2062	168/9376	1.10969470232322	STAT4/SLC25A5/TRAF5/CYLD/BCL2/TRPM7/EIF2AK2/DNM1L/PARP1/VDAC3/CASP8/FASLG/TNFSF10/IRF9/IFNAR2/JAK2/RIPK1/PYCARD/CAMK2G/BID/BAX/MLKL/HMGB1/JAK3/BIRC3/GLUD1/MAPK8/VDAC1/PPID/BIRC2/ZBP1/CHMP6/PYGB/TYK2/TRAF2/CAMK2D/TNFRSF10A/JAK1/TNFAIP3/CHMP1A/RNF31	0.761745908422103
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/2062	32/9376	1.27885548011639	B4GALT1/AKR1B1/GALE/PFKP/UGP2/HKDC1/PGM1/PGM2/GALK1	0.838958056044166
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	18/2062	70/9376	1.16923929610642	NFKB1/ADIPOR2/NFKBIB/ACSL3/JAK2/RXRA/TNFRSF1B/MAPK8/ADIPOR1/IKBKB/ACSL5/PRKAA1/CHUK/SLC2A1/TRAF2/RELA/PRKAB1/NFKBIE	0.754607638359566
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	16/2062	62/9376	1.17343011795626	KRAS/PRKACB/RPTOR/PIK3CD/ADCY7/HDAC2/ATG5/EIF4EBP2/RPS6KB2/HSPA1B/PRKAA1/HSPA8/PIK3CB/FOXO3/ADCY9/PRKAB1	0.727452663085055
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	40/2062	166/9376	1.09567270050133	SLC25A5/PPP3CC/PPP1CA/MAPK1/ATP1B3/MEF2A/ITPR1/MAP2K1/PIK3R6/PIK3CG/PPP1R12A/GNA13/PPP3CA/VASP/NFATC2/VDAC3/PPP3R1/NFATC3/CALM3/ATP1B1/PPP1CC/CREB1/MEF2D/ADCY7/ROCK1/PLCB1/ATP1A1/VDAC1/ATF2/GNAI2/CALM1/KCNMB4/KCNMA1/ATF6B/GNAI3/ITPR3/ADCY9/GNAQ/RHOA/PLCB2	0.660335661950955
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/2062	71/9376	1.15277113700633	IDH2/MAPK1/KRAS/SLC16A3/SLC7A5/MAP2K1/PIK3CD/SLC1A5/G6PD/PFKP/TP53/PIK3CB/SLC2A1/HKDC1/TIGAR/GLS/PDK1/IDH1	0.686064246607641
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	24/2062	97/9376	1.1250412471127	RPS6KA5/MAPK1/ITPR1/PRKACB/NOS1AP/CALM3/CREB1/ADCY7/CAMK2G/PER2/GNGT2/PLCB1/PER1/GNAI2/CALM1/GNB1/GNB5/GNAI3/ITPR3/ADCY9/GNAQ/CAMK2D/GNG5/PLCB2	0.657265848520611
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	28/2062	115/9376	1.10710580694134	KCNQ5/MAPK1/KRAS/ITPR1/PRKACB/MAP2K1/BCL2/PIK3R6/PIK3CG/FYN/PIK3CD/CREB1/ADCY7/JAK2/CAMK2G/GNGT2/PLCB1/GNAI2/PIK3CB/GNB1/GNB5/GNAI3/ITPR3/ADCY9/GNAQ/CAMK2D/GNG5/PLCB2	0.61360019125148
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	19/2062	76/9376	1.13676042677013	EZR/ATP1B3/ACTB/ITPR1/PRKACB/CALM3/ATP1B1/ADCY7/CAMK2G/PLCB1/ATP1A1/GNAI2/CALM1/GNAI3/ITPR3/ADCY9/GNAQ/CAMK2D/PLCB2	0.63559176242719
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/2062	42/9376	1.19089187566394	VDAC3/ACSL3/SLC39A8/TFRC/ATG5/TP53/PCBP2/ATG7/ACSL5/GSS/SLC3A2	0.658310349557678
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/2062	38/9376	1.19658992291592	GFPT1/GALE/UGP2/HKDC1/PGM1/PGM2/HEXB/GNPNAT1/FPGT/GALK1	0.644731080284232
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	10/2062	38/9376	1.19658992291592	CD38/NT5C2/SIRT2/NT5C/PNP/NNT/SIRT7/NMRK1/NADSYN1/BST1	0.644731080284232
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	10/2062	38/9376	1.19658992291592	PTPRC/ZAP70/IL2RG/CD3E/JAK3/TAP1/UNG/TAP2/DCLRE1C/RFXAP	0.644731080284232
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	23/2062	94/9376	1.11257403471119	MMP9/CASP3/TRAF5/MAPK1/GSK3B/NFKB1/TAB2/TBK1/CASP8/ELAVL1/MAPK14/USP25/TRAF6/ANAPC5/SRSF1/MAP3K7/MAPK8/IKBKB/CHUK/JUND/TRAF2/RELA/TNFAIP3	0.582416764175279
Organismal Systems	Nervous system	hsa04730	Long-term depression	15/2062	60/9376	1.13676042677013	MAPK1/KRAS/ITPR1/MAP2K1/GNA13/PPP2R1B/BRAF/PLCB1/PPP2CA/GNAI2/GNAI3/ITPR3/GNAQ/LYN/PLCB2	0.564252930500772
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	31/2062	130/9376	1.0842945609192	MMP9/MAP2K4/MAPK1/KRAS/TGFBR1/PRKACB/TGFB1/MAP2K1/NFKB1/PIK3CD/MAPK14/CREB1/ADCY7/SOS1/GNGT2/PLCB1/MAPK8/GNA15/ATF2/GNAI2/PIK3CB/MAP2K7/GNB1/ATF6B/GNB5/GNAI3/ADCY9/GNG5/RELA/PLCB2/ARRB2	0.513862322080882
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/2062	78/9376	1.10761272351961	MAPK1/TGFB1/PTPN6/NFKB1/TAB2/ITGAM/NFKBIB/MAPK14/TRAF6/JAK2/MAP3K7/ITGA4/IRAK4/C3/IRAK1/RELA/JAK1/NCF1/TAB1	0.506720697674219
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	34/2062	144/9376	1.07360706972734	CASP3/MAP2K4/LPIN1/TRA2B/GSK3B/NFKB1/TAB2/TBK1/ADIPOR2/CASP8/FASLG/MAPK14/TRAF6/RIPK1/LEF1/MAP2K3/MAP3K7/MAPK8/ACACA/ADIPOR1/IRAK4/IKBKB/PRKAA1/C3/IRF3/CHUK/IRAK1/MAP2K7/FOXO3/RELA/PRKAB1/CTNNB1/MAP3K14/TAB1	0.472612678238835
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	29/2062	122/9376	1.08085417627323	CAB39/PPP2R2A/PPP2R5A/RPTOR/ADIPOR2/PIK3CD/PPP2R1B/ELAVL1/RAB8A/CREB1/PPP2R5E/PPP2R5C/PFKP/RAB14/MAP3K7/ACACA/RPS6KB2/CCNA2/PPP2R3C/EEF2K/ADIPOR1/PPP2R2B/EIF4EBP1/PRKAA1/PPP2CA/PIK3CB/STRADA/FOXO3/PRKAB1	0.47727657051418
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	37/2062	158/9376	1.06481356431632	CAB39/RPS6KA3/MAPK1/KRAS/LPIN1/SLC7A5/GSK3B/MAP2K1/RICTOR/RPTOR/EIF4E/PIK3CD/FNIP1/WNT6/ATP6V1H/SOS1/DDIT4/BRAF/RPS6KB2/IKBKB/EIF4EBP1/PRKAA1/LAMTOR4/CHUK/PIK3CB/RPS6KA2/SLC3A2/STRADA/SEH1L/DVL3/WNT4/RPS6KA1/ATP6V1B2/RHOA/TTI1/NPRL3/GRB10	0.436243116915536
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	25/2062	105/9376	1.08262897787631	KRAS/HUWE1/TBK1/RRAS2/CCZ1B/CSNK2B/CSNK2A1/OPA1/TP53/TOMM40/BCL2L1/MAPK8/GABARAPL1/EIF2AK3/SMURF2/SMURF1/CCZ1/FOXO3/SP1/USP15/TRAF2/RHOT2/RELA/TFEB/RAB5B	0.452080974259332
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	17/2062	70/9376	1.10428155743384	RAC2/CASP3/SNTB1/PRF1/ACTB/ITGAL/FYN/CASP8/CYCS/HLA-F/BID/ICAM1/EIF4G1/DAG1/SGCE/HLA-E/HLA-A	0.464972743269535
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	36/2062	154/9376	1.0629448146422	RPS6KA5/PPP1CA/MAPK1/PPP2R2A/ATP1B3/PRKACB/BCL2/PPP2R5A/PIK3R6/PIK3CG/CREM/PPP2R1B/CALM3/MAPK14/ATP1B1/PPP1CC/TPM3/CREB1/PPP2R5E/ADCY7/PPP2R5C/CAMK2G/PLCB1/ATP1A1/PPP2R3C/ATF2/PPP2R2B/PPP2CA/GNAI2/CALM1/ATF6B/GNAI3/ADCY9/GNAQ/CAMK2D/PLCB2	0.41817710444347
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	36/2062	154/9376	1.0629448146422	CD38/PPP3CC/PPP1CA/MAPK1/KRAS/ACTB/ITPR1/PRKACB/MAP2K1/PIK3R6/PIK3CG/PPP1R12A/PPP3CA/NFATC2/PPP3R1/NFATC3/CALM3/PPP1CC/ADCY7/CAMK2G/ROCK1/PLCB1/EEF2K/PPP1R12B/PRKAA1/GNAI2/CALM1/GNAI3/ITPR3/ADCY9/GNAQ/CAMK2D/RHOA/PLCB2/PRKAB1/CAMK1D	0.41817710444347
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/2062	57/9376	1.11681726138819	ACAT2/TECR/ACSL3/ELOVL5/ELOVL1/HACD1/ACACA/HACD4/HACD2/HADH/ACSL5/HACD3/ELOVL6/ACADS	0.469691048391126
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/2062	31/9376	1.17343011795626	G6PD/PFKP/RBKS/PGD/RPIA/PGM1/PGM2/PRPS1	0.513532819440741
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/2062	31/9376	1.17343011795626	PGP/ACAT2/CS/MDH2/MDH1/SHMT1/SHMT2/ACSS1	0.513532819440741
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/2062	31/9376	1.17343011795626	SRP54/SEC11C/SRP19/IMMP1L/GET3/SGTA/SRPRB/SEC11A	0.513532819440741
NA	NA	hsa04981	Folate transport and metabolism	8/2062	31/9376	1.17343011795626	TYMS/DHFR/FPGS/ABCC1/MTHFD1/SHMT1/ABCC4/SHMT2	0.513532819440741
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	47/2062	203/9376	1.05276335090041	RAC2/VAV3/ACTN4/DIAPH1/CCND3/PPP1CA/MAPK1/ACTB/GSK3B/MAP2K1/BCL2/PPP1R12A/RAP1A/VASP/RAPGEF1/PARVG/FYN/PIK3CD/ITGA1/CCND2/PPP1CC/SOS1/ROCK1/BRAF/ILK/BIRC3/CRK/MAPK8/ITGA4/VAV1/PPP1R12B/BIRC2/PARVB/PIK3CB/MYL12A/PXN/ITGB7/TLN2/FLNB/ITGA3/CRKL/RHOA/PAK4/PAK1/CTNNB1/THBS1/VTN	0.40353125849141
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	26/2062	110/9376	1.07475531258266	PLCG2/MAPK1/MAP2K1/BCL2/EP300/EPAS1/NFKB1/EIF4E/PIK3CD/CAMK2G/RBX1/TFRC/PGK1/PFKP/ENO1/CUL2/RPS6KB2/EIF4EBP1/PIK3CB/SLC2A1/HKDC1/SERPINE1/GAPDH/CAMK2D/RELA/PDK1	0.418740287711845
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	25/2062	106/9376	1.07241549695295	MMP9/MAPK1/KRAS/GSK3B/MAP2K1/BCL2/EP300/GSTP1/NFKB1/E2F3/PIK3CD/CREB1/LEF1/SOS1/BRAF/TP53/IKBKB/MDM2/CHUK/PIK3CB/IL1R2/CDK2/CCNE2/RELA/CTNNB1	0.398104486182881
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	47/2062	204/9376	1.04760274623914	MMP9/VAV3/HCLS1/TIAM1/ARHGEF1/PLCG2/CASP3/EZR/PPP1CA/MAPK1/KRAS/ACTB/ITPR1/PRKACB/TGFB1/MAP2K1/PTPN6/PPP1R12A/RRAS2/PIK3CD/WNT6/CBL/FASLG/MAPK14/IQGAP1/PPP1CC/SOS1/CAMK2G/MSN/ROCK1/BRAF/TP53/RPS6KB2/VAV1/PPP1R12B/MDM2/PIK3CB/PXN/ITPR3/WNT4/DROSHA/CAMK2D/RHOA/PAK1/CTNNB1/THBS1/VTN	0.364978733301976
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/2062	80/9376	1.07992240543162	PLCG2/MAPK1/KRAS/GSK3B/MAP2K1/BCL2/BCL2L11/EIF4E/PIK3CD/JAK2/SOS1/BAX/BRAF/BCL2L1/RPS6KB2/EIF4EBP1/PIK3CB/FOXO3/JAK1	0.381169351320648
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/2062	23/9376	1.18618479315144	ATP1B3/ATP1B1/GLUD1/ATP1A1/MDH1/GLS	0.47466274682413
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	21/2062	89/9376	1.07289748144596	TUBA1B/MAPK1/KRAS/ITPR1/PRKACB/MAP2K1/ADCY7/SOS1/CDK1/PLCB1/TUBA4A/TUBB/GNAI2/MAP3K2/TUBA1C/TUBB4B/GNAI3/ITPR3/ADCY9/GNAQ/PLCB2	0.366878528290618
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/2062	45/9376	1.11149908395301	KLRC1/PRF1/GZMB/KLRD1/FASLG/HLA-F/KIR2DL3/KIR2DL1/HLA-E/KIR3DL1/HLA-A	0.398075960984912
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	32/2062	139/9376	1.04680096853652	MMP9/CTSD/MAPK1/KRAS/ITPR1/PRKACB/MAP2K1/NCOA1/BCL2/PIK3CD/CALM3/NCOA2/CREB1/ADCY7/SOS1/NCOA3/FKBP5/PLCB1/HSPA1B/ATF2/KRT23/GNAI2/HSPA8/CALM1/PIK3CB/ATF6B/GNAI3/SP1/ITPR3/ADCY9/GNAQ/PLCB2	0.295154398614756
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	54/2062	238/9376	1.0316817318586	RASA2/RAC2/ZAP70/TIAM1/PLCG2/STK4/MAPK1/KRAS/KSR1/RALGAPA1/ETS1/PRKACB/RASSF1/MAP2K1/CSF1/NFKB1/RALBP1/RAP1A/TBK1/RASSF5/RRAS2/PIK3CD/REL/RASAL3/ARF6/FASLG/CALM3/PLD1/RASGRP1/SOS1/EXOC2/RALGAPB/ETS2/BCL2L1/PLAAT3/GNGT2/MAPK8/PLA2G6/IKBKB/RASGRP2/CHUK/CALM1/PIK3CB/BRAP/AFDN/GNB1/GNB5/LAT/RHOA/GNG5/PAK4/RELA/PAK1/RAB5B	0.262859880603557
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/2062	59/9376	1.07895904913775	IDH2/SMS/GSTP1/RRM2/RRM1/MGST2/G6PD/GGCT/PGD/GSR/GSS/GGT5/CHAC2/IDH1	0.323029628883455
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	34/2062	149/9376	1.03757998685058	SYK/PLCG2/PTK2B/MAPK1/KRAS/DGKZ/MAP2K1/CYTH4/FCER1G/PIK3R6/PIK3CG/GNA13/CYTH1/DGKE/FYN/RRAS2/PIK3CD/DGKD/ARF6/AGPAT5/PLD1/DNM2/ADCY7/SOS1/AGPAT4/PLCB1/PIK3CB/LPAR3/DGKQ/CYTH2/ADCY9/RHOA/PLCB2/DGKB	0.245511584039224
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	34/2062	149/9376	1.03757998685058	MAPK1/NDUFB3/ITPR1/NDUFV1/PRKACB/NDUFA7/NDUFS7/NDUFS8/NDUFS6/NDUFAB1/NDUFB9/MAPK14/ADCY7/NDUFA3/GNGT2/PLCB1/MAPK8/NDUFA9/NDUFB4/NDUFB6/GNAI2/NDUFB8/GNB1/GNB5/GNAI3/DAGLB/ITPR3/ADCY9/GNAQ/MT-ND4/GNG5/PLCB2/NDUFC2/NDUFA13	0.245511584039224
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	14/2062	60/9376	1.06097639831878	RAC2/PLCG2/PPP3CC/MAPK1/KRAS/MAP2K1/PPP3CA/NFATC2/PIK3CD/PPP3R1/MAPK14/SH2D2A/PIK3CB/PXN	0.251579438989233
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/2062	29/9376	1.09756179136426	RASSF1/LATS1/MOB1A/CSNK1E/NF2/LIMD1/PAK1	0.279379884979853
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	23/2062	101/9376	1.03546494319655	MAPK1/KRAS/PRKACB/GSK3B/MAP2K1/EP300/WNT6/CALM3/CREB1/ADCY7/LEF1/CAMK2G/PLCB1/GNAI2/CALM1/GNAI3/DVL3/ADCY9/WNT4/GNAQ/CAMK2D/PLCB2/CTNNB1	0.190263502382852
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	15/2062	65/9376	1.04931731701858	LDLR/ITPR1/PRKACB/CREB1/ADCY7/NR4A1/PLCB1/ATF2/NCEH1/ATF6B/SP1/ITPR3/ADCY9/GNAQ/PLCB2	0.211841209602085
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	17/2062	75/9376	1.03066278693825	ATP1B3/ITPR1/PRKACB/TTF1/TTF2/ATP1B1/CREB1/ADCY7/PLCB1/ATP1A1/GSR/ATF2/ATF6B/ITPR3/ADCY9/GNAQ/PLCB2	0.141556535646921
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	11/2062	48/9376	1.04203039120595	OXCT1/HMGCS1/ACAT2/HIBCH/IVD/AACS/MCCC2/HADH/BCKDHB/ACADS/DBT	0.155003774194472
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/2062	39/9376	1.04931731701858	MTHFD2/MAT2A/TYMS/DHFR/GART/MTHFD1/SHMT1/SHMT2/MTHFD2L	0.163862869839285
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/2062	30/9376	1.06097639831878	PIGK/PIGS/DPM2/PIGF/PIGU/PIGA/PIGH	0.177607784998861
Cellular Processes	Cell motility	hsa04814	Motor proteins	43/2062	194/9376	1.00784945053846	KIF13B/KIF18A/TUBA1B/ACTB/KIF20B/MYO1E/MYO1G/KIF22/CENPE/KIF11/KIFC1/TPM3/STARD9/KIF2C/KIF2A/KIF21A/KLC1/KIF21B/DCTN4/KIF4A/KIF14/CAPZB/KIF18B/TUBA4A/KIF23/KIF15/MYO1F/MYO9B/TUBB/DYNC1H1/CAPZA1/MYO19/KIFAP3/TUBA1C/DNAH14/DCTN5/MYL12A/DYNLRB1/TUBB4B/MYH9/MYO18B/KLC2/KIF7	0.0586575566375178
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/2062	12/9376	1.13676042677013	VKORC1L1/COQ4/COQ2	0.25169399756616
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/2062	12/9376	1.13676042677013	NCAM1/CD46/NPC1	0.25169399756616
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/2062	35/9376	1.03932381876126	GMDS/AKR1B1/PFKP/HKDC1/TIGAR/TKFC/FPGT/TPI1	0.123750086915643
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	22/2062	99/9376	1.01045371268456	RAC2/CHKA/MAPK1/KRAS/DGKZ/MAP2K1/SLC44A1/WAS/DGKE/PIK3CD/LYPLA1/DGKD/PLD1/SOS1/MAPK8/RPS6KB2/EIF4EBP1/GPCPD1/PIK3CB/DGKQ/SP1/DGKB	0.0555183907498919
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/2062	17/9376	1.06989216637188	TFRC/DAG1/MYH9/PCDH20	0.153140735916863
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	24/2062	109/9376	1.00118349513699	RPS6KA3/PPP1CA/PTPN1/GSK3B/NFKB1/PIK3CD/PPP1CC/TBC1D4/GFPT1/CREB1/OGA/OGT/MAPK8/SLC27A2/RPS6KB2/IKBKB/PRKAA1/PIK3CB/RPS6KA2/SLC2A1/PYGB/RPS6KA1/RELA/PRKAB1	0.00659876459959512
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	18/2062	82/9376	0.998131106432306	GMPS/UPP1/GSTP1/RRM2/HPRT1/RRM1/MGST2/CDA/NME1/GUSB/UCK2/UMPS/CMPK1/DUT/TK1/NME7/TPMT/IMPDH1	-0.00902490527113461
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	31/2062	142/9376	0.992664034644335	MMP9/RAC2/MAP2K4/ACTB/MEF2A/BCL2/GSTP1/NFKB1/PIK3CD/MGST2/CALM3/MAPK14/PECAM1/KLF2/ICAM1/TP53/MAP3K7/MAPK8/IKBKB/SUMO1/PRKAA1/CHUK/CALM1/PIK3CB/MAP2K7/IL1R2/RHOA/RELA/KEAP1/NCF1/CTNNB1	-0.0467690985784484
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/2062	36/9376	1.01045371268456	GYG1/UGP2/AGL/GBE1/PYGB/HKDC1/PGM1/PGM2	0.0333657477763006
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/2062	101/9376	0.990444728274961	PLCG2/CASP3/DIAPH1/MAPK1/KRAS/TGFBR1/TGFB1/BCL2/NFKB1/PIK3CD/MAPK14/SMAD4/PIM1/JAK2/ICAM1/BAX/PLCB1/MAPK8/PIK3CB/SERPINE1/RELA/PLCB2	-0.0512624383620193
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	40/2062	184/9376	0.988487327626197	RAC2/SEMA4D/PLCG2/PPP3CC/SRGAP3/SSH2/MAPK1/KRAS/GSK3B/PPP3CA/FYN/NFATC2/PIK3CD/PPP3R1/NFATC3/SSH1/LIMK1/PLXNC1/CAMK2G/ROCK1/SEMA3A/SEMA3B/ILK/NCK1/SRGAP2/RGS3/RYK/GNAI2/PIK3CB/CFL1/MYL12A/GNAI3/WNT4/SEMA4A/CAMK2D/RHOA/PAK4/PAK1/UNC5B/PARD6B	-0.0837399196953283
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	15/2062	69/9376	0.988487327626197	PPP3CC/PPP1CA/PRKACB/PPP3CA/PPP3R1/CALM3/PPP1CC/CREB1/HDAC2/CAMK2G/ATF2/CALM1/ATF6B/CAMK2D/MAOA	-0.050962218414338
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/2062	32/9376	0.99466537342386	SUCLG2/HIBCH/ACACA/BCKDHB/ACSS1/ACADS/DBT	-0.0160496323764972
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/2062	51/9376	0.980734485840893	PLCG2/ACTB/PRKACB/TCIRG1/ATP6V1H/ATP6V0A2/ERO1A/ATP6V0B/ATP6V0C/ADCY9/ATP6V1B2	-0.0732476612418675
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/2062	37/9376	0.983144152882271	APOA1/FASLG/ICAM1/IL18/PLCB1/GNAQ/PLCB2/THOP1	-0.0545448495994174
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/2062	23/9376	0.988487327626197	LNPEP/PREP/REN/CTSA/THOP1	-0.0293506069950142
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/2062	47/9376	0.967455682357554	ACAT2/ME2/GLO1/ACACA/MDH2/MDH1/HAGH/ACYP1/ACSS1/DLAT	-0.118756952188436
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/2062	19/9376	0.957271938332738	IDS/GUSB/ARSB/HEXB	-0.0989860896411009
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/2062	19/9376	0.957271938332738	OGDH/BCKDHB/DLAT/DBT	-0.0989860896411009
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	18/2062	86/9376	0.951706403807547	ATP1B3/PRKACB/ATP1B1/CREB1/ADCY7/CAMK2G/PLCB1/ATP1A1/ATF2/KCNMB4/SLC2A1/KCNMA1/ATF6B/ITPR3/ADCY9/GNAQ/CAMK2D/PLCB2	-0.238881988599791
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/2062	44/9376	0.930076712811921	ARHGDIB/PRKACB/CREB1/ARHGDIA/DCTN4/DYNC1H1/DCTN5/ADCY9/RAB5B	-0.246838728552738
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	10/2062	49/9376	0.927967695322552	PRKACB/NFKB1/CREB1/ATF2/GNAI2/ATF6B/GNAI3/RELA/MAOA/RGS9	-0.268415043547533
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	24/2062	116/9376	0.940767249740794	SLC38A1/PPP3CC/GRK2/MAPK1/ITPR1/PRKACB/PPP3CA/PPP3R1/PLD1/ADCY7/GNGT2/PLCB1/GNAI2/GNB1/GNB5/GNAI3/ITPR3/ADCY9/GLS/HOMER2/GNAQ/GNG5/PLCB2/SLC1A1	-0.340830059167336
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/2062	20/9376	0.909408341416101	GMDS/UGP2/CYB5R4/TGDS	-0.215333000937205
NA	NA	hsa04518	Integrin signaling	32/2062	154/9376	0.944839835237507	ITGAD/RAC2/ARHGEF6/ACTN4/CCND3/ACTB/TGFB1/GSK3B/FERMT3/ITGAX/ITGAL/ITGAM/PARVG/PIK3CD/ITGA1/CCND2/ICAM3/ICAM1/ILK/ITGA4/ITGAE/C3/PARVB/PIK3CB/PXN/ITGB7/TLN2/FLNB/ITGA3/CTNNB1/THBS1/VTN	-0.366459383701814
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	76/2062	362/9376	0.954627540713034	PRL/CDK6/SYK/IL2RB/PIK3AP1/IL2RG/CCND3/MAPK1/KRAS/PPP2R2A/AREG/GSK3B/PHLPP1/MAP2K1/BCL2/PPP2R5A/CSF1/BCL2L11/PIK3R6/NFKB1/PIK3CG/RPTOR/EIF4E/PIK3CD/ITGA1/CCND2/PPP2R1B/FASLG/CREB1/PPP2R5E/YWHAH/BRCA1/IFNAR2/PPP2R5C/NR4A1/JAK2/SOS1/DDIT4/RXRA/OSM/RBL2/TP53/JAK3/BCL2L1/YWHAZ/GNGT2/RPS6KB2/PPP2R3C/ITGA4/ATF2/CDC37/IKBKB/PPP2R2B/EIF4EBP1/PRKAA1/PPP2CA/MDM2/CHUK/PIK3CB/ITGB7/LPAR3/GNB1/ATF6B/GNB5/FOXO3/ITGA3/IL4R/CDK2/CCNE2/PHLPP2/GNG5/RELA/JAK1/THEM4/THBS1/VTN	-0.467455548124515
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/2062	26/9376	0.874431097515482	APOA1/LMBRD1/ABCC1/BTD/SLC19A2	-0.340420305880133
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/2062	21/9376	0.866103182301048	CHST12/XYLT1/CHST11/CHSY1	-0.326144829187794
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/2062	51/9376	0.891576805309903	AGPS/SELENOI/PAFAH1B2/PLD1/PLAAT3/PLA2G6/LPCAT1/CEPT1/ENPP6/PAFAH1B1	-0.412225979012721
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/2062	16/9376	0.852570320077595	GOT2/GOT1/MAOA	-0.313371488361413
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/2062	16/9376	0.852570320077595	ST3GAL1/HEXB/ST3GAL2	-0.313371488361413
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/2062	53/9376	0.857932397562359	ATP1B3/PRKACB/ATP1B1/DNM2/PLCB1/ATP1A1/VDR/ADCY9/GNAQ/PLCB2	-0.550690563578131
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/2062	63/9376	0.866103182301048	GSK3B/WNT6/LEF1/BAX/DDB2/TP53/DVL3/WNT4/SUFU/AXIN1/CTNNB1/KIF7	-0.566171780600887
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/2062	43/9376	0.845961247828931	GCDH/ACAT2/ACSL3/ECI2/ECI1/HADH/ACSL5/ACADS	-0.537534170846878
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/2062	38/9376	0.837612946041146	MAPK1/KRAS/ATP1B3/PIK3CD/ATP1B1/ATP1A1/PIK3CB	-0.532560261330601
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/2062	28/9376	0.811971733407233	ST3GAL3/B4GALT1/B3GNT2/B4GALT4/B4GALT3	-0.529048267896249
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/2062	18/9376	0.757840284513417	ACSL3/ACACA/ACSL5	-0.54600814400972
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/2062	134/9376	0.882261823761889	PRKCH/ARHGEF1/PPP1CA/MAPK1/ITPR1/PRKACB/MAP2K1/PPP1R12A/GNA13/CALM3/PPP1CC/ADCY7/ROCK1/BRAF/PLCB1/PLA2G6/PPP1R12B/CALM1/KCNMB4/KCNMA1/ITPR3/ADCY9/MYH9/GNAQ/RHOA/PLCB2	-0.728851768800406
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/2062	55/9376	0.826734855832819	B4GALT5/SGMS1/B4GALT6/UGCG/GALC/CERS6/NEU1/HEXB/SMPD4/NEU3	-0.684248392348393
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/2062	50/9376	0.818467507274491	SMS/PYCR2/ALDH18A1/GAMT/GOT2/GOT1/ARG1/MAOA/SMOX	-0.683351510161037
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/2062	45/9376	0.808362970147645	ABCB1/ABCB10/ABCC1/TAP1/ABCB7/TAP2/ABCC4/ABCA7	-0.684185843633647
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/2062	46/9376	0.790789862100957	HMOX2/GUSB/BLVRA/ALAS1/MMAB/HMBS/COX10/HCCS	-0.755219700542155
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	16/2062	87/9376	0.83623755532515	ATP1B3/UQCRC2/ATP1B1/TPM3/COX8A/COX5A/COX7B/ATP1A1/COX6B1/MT-CO2/COX7A2/UQCRQ/UQCR11/COX6A1/COX6A2/UQCR10	-0.814782980045435
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	19/2062	102/9376	0.846997965044408	CD38/ATP1B3/ITPR1/RAP1A/ATP1B1/RAB8A/ADCY7/PLCB1/ATP1A1/PRSS3/KCNMA1/ITPR3/ADCY9/GNAQ/CPA1/RHOA/PLCB2/BST1/CPB1	-0.824928366588136
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/2062	93/9376	0.831179666885684	CD38/ATP1B3/ITPR1/PRKACB/CALM3/ATP1B1/ADCY7/PLCB1/ATP1A1/LYZ/CALM1/KCNMA1/ITPR3/ADCY9/GNAQ/PLCB2/BST1	-0.8687094434369
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/2062	47/9376	0.773964545886043	MAPK1/PIK3CD/SOCS1/SOCS4/MAPK8/IKBKB/PIK3CB/HKDC1	-0.824822382574472
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/2062	73/9376	0.809747153315706	CDK6/CDKN2A/MAPK1/KRAS/MAP2K1/E2F3/PIK3CD/BAX/BRAF/DDB2/TP53/MDM2/PIK3CB	-0.866430184902861
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	28/2062	148/9376	0.860251133771987	CDK6/MAPK1/KRAS/GSK3B/MAP2K1/NCOA1/E2F3/PIK3CD/WNT6/BRCA1/BRCA2/LEF1/SOS1/NCOA3/NOTCH2/BAX/BRAF/DDB2/TP53/RPS6KB2/PIK3CB/NFKB2/SP1/DVL3/WNT4/NOTCH1/AXIN1/CTNNB1	-0.909866863291417
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	35/2062	183/9376	0.8696527855072	MDN1/NOP58/NOP56/XPO1/GNL2/WDR43/WDR36/DKC1/RRP7A/NAT10/XRN1/LSG1/POP4/CSNK2B/BMS1/CSNK2A1/FBL/RPP30/GNL3/REXO1/RCL1/NXT1/SNU13/UTP18/UTP4/EFL1/NOP10/RAN/GAR1/UTP14A/POP7/DROSHA/POP1/NXT2/WDR3	-0.945477417426959
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/2062	48/9376	0.757840284513417	ATP1B3/PIK3CD/ATP1B1/PLCB1/ATP1A1/PIK3CB/HKDC1/PLCB2	-0.893060206705073
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	28/2062	150/9376	0.848781118655027	MAPK1/KRAS/TGFBR1/TGFB1/GSK3B/MAP2K1/BCL2/E2F3/PIK3CD/WNT6/SMAD4/LEF1/SOS1/ABCB1/RXRA/BAX/BRAF/DDB2/TP53/RPS6KB2/PIK3CB/MLH1/DVL3/WNT4/CDK2/CCNE2/AXIN1/CTNNB1	-0.991282447080088
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/2062	59/9376	0.77068503509839	PRKACB/PIK3CD/ADCY7/PLAAT3/PNPLA2/GNAI2/PIK3CB/GNAI3/PLIN1/ADCY9	-0.938151216592819
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/2062	21/9376	0.649577386725786	PANK2/PPCDC/PANK3	-0.85355668128589
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/2062	65/9376	0.769499365813624	MAPK1/KRAS/ITPR1/MAP2K1/PIK3CD/PLCB1/PIK3CB/ITPR3/GNAQ/PLCB2/ARRB2	-0.990109278282426
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/2062	91/9376	0.799479860585583	PDE7A/PDE4A/GRK2/PRKACB/ADCY7/PDE4B/GNGT2/GNAI2/GNB1/GRK5/GNB5/GNAI3/ADCY9/GNG5/ARRB2/PDE4D	-1.020563967075
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/2062	44/9376	0.723392998853717	PRF1/GZMB/FASLG/HLA-F/HSPD1/HLA-E/HLA-A	-0.976460392774196
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/2062	66/9376	0.757840284513417	STAT4/IL2RG/GATA3/TGFB1/NFKB1/IL18/IL21R/NOD2/IL4R/RELA/IL12RB1	-1.04821776470554
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/2062	39/9376	0.699544878012385	PRF1/GZMB/FASLG/HLA-F/HLA-E/HLA-A	-0.998299208536764
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/2062	50/9376	0.727526673132881	KLRB1/KLRK1/TGFB1/ITGAL/PECAM1/ICAM1/IL18/THBS1	-1.02568447443064
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	31/2062	168/9376	0.839037457854141	STAT4/PRL/IL2RB/STAM/IL2RG/CCND3/PIAS1/BCL2/EP300/PTPN6/PIK3CD/SOCS1/PTPN2/CCND2/IRF9/IFNAR2/PIM1/JAK2/SOS1/OSM/SOCS4/JAK3/BCL2L1/IL21R/PIK3CB/IL27RA/TYK2/IL4R/JAK1/CISH/IL12RB1	-1.11776189088464
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/2062	61/9376	0.745416673291886	ATP1B3/TRPM7/ATP1B1/HMOX2/SLC39A4/ATP1A1/VDR/SLC31A1/MT1X/ATP7A	-1.05914625706092
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/2062	28/9376	0.649577386725786	TCIRG1/ATP6V0A2/ATP6V0C/ATP6V1B2	-0.985971311355647
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	26/2062	144/9376	0.820993641556202	ZFHX3/MAPK1/KRAS/RIF1/ID3/GSK3B/MAP2K1/ID2/JARID2/PIK3CD/WNT6/MAPK14/SMAD4/JAK2/SMARCAD1/KAT6A/JAK3/ID1/PIK3CB/DVL3/WNT4/JAK1/TCF3/AXIN1/CTNNB1/PCGF6	-1.14935528338903
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/2062	67/9376	0.746529235490829	ADPGK/PGK1/PFKP/ENO1/HKDC1/PGM1/PGM2/GAPDH/ACSS1/DLAT/TPI1	-1.10551910341881
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	28/2062	155/9376	0.821401082569381	CORO1A/TUBA1B/ACTB/ITGAM/TCIRG1/ATP6V1H/ATP6V0A2/HLA-F/TFRC/PIKFYVE/TUBA4A/ATP6V0B/TUBB/TAP1/STX18/DYNC1H1/C3/TUBA1C/TAP2/ATP6V0C/HLA-E/TUBB4B/HGS/ATP6V1B2/NCF1/THBS1/RAB5B/HLA-A	-1.19044175338089
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/2062	29/9376	0.627178166493863	CALM3/CALM1/GNB1/RGS9	-1.06762001298266
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/2062	23/9376	0.593092396575718	ST3GAL3/B4GALT1/B4GALT3	-1.0373773146333
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	42/2062	226/9376	0.845025449988412	RAC2/VAV3/TIAM1/PDE4A/PPP1CA/MAPK1/ATP1B3/PRKACB/MAP2K1/EP300/NFKB1/PPP1R12A/RAP1A/RRAS2/PIK3CD/CALM3/ATP1B1/PPP1CC/CREB1/PLD1/ADCY7/CAMK2G/PDE4B/ROCK1/BRAF/PTGER2/MAPK8/ATP1A1/VAV1/GNAI2/CALM1/PIK3CB/ABCC4/AFDN/GNAI3/FXYD1/ADCY9/CAMK2D/RHOA/RELA/PAK1/PDE4D	-1.25215054597325
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/2062	100/9376	0.772997090203686	XCL2/CCR1/IL2RB/IL2RG/XCL1/CSF1/CXCR3/TNFSF10/TNFRSF1B/IL18/CCL28/CCL3/TNFSF14/CCL8/TNFRSF10A/CCL21/TNFRSF14	-1.21172353969089
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/2062	17/9376	0.534946083185942	GGT5/ADO	-1.01897970486396
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/2062	17/9376	0.534946083185942	KYAT3/SEPHS1	-1.01897970486396
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/2062	10/9376	0.45470417070805	MPST	-0.91602555560402
NA	NA	hsa03272	Virion - Hepatitis viruses	7/2062	48/9376	0.66311024894924	LDLR/CD9/PDCD6IP/IST1/TSG101/CLDN4/CHMP1A	-1.24241486700492
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/2062	76/9376	0.717953953749553	APOA1/HMGCS1/ACSL3/RXRA/ILK/SLC27A2/FABP5/ACSL5/PLIN1/GK/SORBS1/DBI	-1.31080421329236
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	38/2062	217/9376	0.796256151470319	KPNA1/RPS6KA3/CCND3/MAPK1/KRAS/PRKACB/MAP2K1/BCL2/KPNB1/NFKB1/PIK3CD/KPNA6/MGST2/KPNA2/CREB1/ADCY7/KPNA3/JAK2/SOS1/NOTCH2/RXRA/BIRC5/RPS6KB2/CDC6/ATF2/EIF4EBP1/GNAI2/PIK3CB/RPS6KA2/CDC25A/VDR/ATF6B/AHR/GNAI3/ADCY9/RPS6KA1/RELA/ARRB2	-1.61228878625384
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/2062	103/9376	0.706336575857166	ACTN4/CASP3/PRKACB/TGFB1/NFKB1/ITGAM/PIK3CD/PLCB1/GNA15/PIK3CB/IL1R2/GNAQ/RELA/PLCB2/ARG1/RAB5B	-1.59114893161163
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/2062	41/9376	0.554517281351281	ALAS1/SHMT1/GAMT/SHMT2/MAOA	-1.51781247939385
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	18/2062	115/9376	0.711710875890862	CASP3/MAPK1/KRAS/ITPR1/PRKACB/MAP2K1/BRAF/GNGT2/PLCB1/GNAI2/GNB1/GNB5/GNAI3/ITPR3/GNAQ/GNG5/PLCB2/MAOA	-1.65158423003125
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/2062	42/9376	0.541314488938155	GCDH/ACAT2/KYAT3/HADH/MAOA	-1.58182436038164
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/2062	22/9376	0.41336742791641	CARNMT1/MAOA	-1.46261937220851
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	58/2062	323/9376	0.816496653283806	MMP9/STMN1/CDK6/SPRY2/RPS6KA5/PLCG2/CASP3/EZR/DNMT1/CDKN2A/MAPK1/KRAS/EZH2/RASSF1/MAP2K1/BCL2/EP300/BCL2L11/NFKB1/RPTOR/E2F3/PIK3CD/SOCS1/CCND2/SLC7A1/BRCA1/PIM1/FOXP1/HDAC2/DICER1/SOS1/ABCB1/CDCA5/UBE2I/NOTCH2/DDIT4/ROCK1/TP53/DNMT3A/ABCC1/CDC25B/CRK/CCNG1/KIF23/IKBKB/MDM2/PIK3CB/HDAC5/CDC25A/DNMT3B/GLS/NOTCH1/CRKL/CCNE2/RHOA/PAK4/THBS1/CDC25C	-1.78197448329639
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/2062	89/9376	0.66417463137131	SLC38A1/PRKACB/ADCY7/GNGT2/GABARAPL1/GNAI2/GNB1/GNB5/GNAI3/ADCY9/GLS/GPHN/GNG5	-1.69014230068402
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/2062	36/9376	0.505226856342278	DCXR/AKR1B1/GUSB/UGP2	-1.5791974024845
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/2062	95/9376	0.670090356832916	TGFB1/CSF1/ITGAL/TCIRG1/ATP6V1H/ATP6V0A2/ICAM1/ACP5/IL18/ATP6V0B/CCL3/ATP6V0C/ATP6V1B2/TNFSF13B	-1.71597879584724
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	11/2062	79/9376	0.633132389593488	TCIRG1/ATP6V1H/ATP6V0A2/DNM2/NAPA/ATP6V0B/STX2/STX3/ATP6V0C/ATP6V1B2/SLC1A1	-1.73861728020644
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/2062	15/9376	0.303136113805367	AK2	-1.43411822887915
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/2062	50/9376	0.54564500484966	TGFB1/ITGA4/CCL28/ITGB7/MAP3K14/TNFSF13B	-1.71035040296984
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/2062	31/9376	0.440036294233597	HIBCH/ACADS/SMOX	-1.65807268077412
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	32/2062	195/9376	0.746181203213211	RAC2/SYK/PLCG2/SLC25A5/MAPK1/ACTB/MAP2K1/HDAC9/NFKB1/SELPLG/ITGAL/ITGAM/PIK3CD/VDAC3/HAT1/MAPK14/HDAC2/HMGB1/ATG7/MAP3K7/PLCB1/VDAC1/GSDMD/C3/PIK3CB/HDAC8/HDAC7/HDAC5/HDAC3/RELA/PLCB2/NCF1	-1.90172880062105
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/2062	24/9376	0.378920142256709	XYLT1/HS2ST1	-1.61753358715664
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/2062	100/9376	0.636585838991271	CD7/CD38/CD37/CSF1/ITGAM/CD3E/ITGA1/CD9/TFRC/ITGA4/CD2/IL1R2/ITGA3/IL4R	-1.93987598637576
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/2062	17/9376	0.267473041592971	ACOT8	-1.60503992525437
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/2062	17/9376	0.267473041592971	GLUD1	-1.60503992525437
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/2062	26/9376	0.349772439006193	PLAAT3/PLA2G6	-1.76278251084098
Organismal Systems	Digestive system	hsa04976	Bile secretion	12/2062	90/9376	0.606272227610734	LDLR/ATP1B3/PRKACB/ATP1B1/ADCY7/ABCB1/RXRA/ATP1A1/NCEH1/ABCC4/SLC2A1/ADCY9	-1.99276210278827
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/2062	54/9376	0.505226856342278	PRF1/GZMB/FASLG/HLA-F/HLA-E/HLA-A	-1.9359803249396
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	39/2062	238/9376	0.74510347300899	ISG15/SYK/PLCG2/MAPK1/MX1/CGAS/NFKB1/EIF2AK2/TAB2/TBK1/PIK3CD/ADAR/NFKBIB/MAPK14/IRF9/IFNAR2/TRAF6/RPL36AL/RSL24D1/MAP3K7/MAPK8/IRAK4/IKBKB/OAS2/C3/IRF3/CHUK/PIK3CB/IRAK1/RPL22L1/RPS27L/OAS3/IFIH1/TYK2/OAS1/RPL35/RELA/JAK1/RPS19	-2.11484873838822
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/2062	99/9376	0.597086284768147	SNTB1/ACTB/TGFB1/ITGA1/TPM3/ITGA4/TTN/DAG1/PRKAA1/SGCE/ITGB7/ITGA3/PRKAB1	-2.13982551039297
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/2062	105/9376	0.606272227610734	SNTB1/ACTB/PRKACB/TGFB1/ITGA1/TPM3/ADCY7/ITGA4/TTN/DAG1/SGCE/ITGB7/ADCY9/ITGA3	-2.15416963285137
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/2062	43/9376	0.422980623914466	APOA1/ACAT2/DGAT1/GOT2	-2.01356884235378
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/2062	37/9376	0.368679057330852	GOT2/GOT1/MAOA	-2.04292941353462
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/2062	52/9376	0.437215548757741	LDLR/PRKACB/ADCY7/HSD17B7/ADCY9	-2.160703225218
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2062	30/9376	0.303136113805367	PLAAT3/PLA2G6	-2.02977635093608
Genetic Information Processing	Translation	hsa03010	Ribosome	34/2062	222/9376	0.696393774958275	MRPL52/MRPL12/MRPS34/MRPS6/MRPS28/MRPL54/MRPL47/RPL36AL/MRPL1/MRPL33/MRPS35/MRPS11/RSL24D1/MRPS15/MRPL4/MRPL48/MRPL13/DAP3/MRPS31/MRPL22/MRPS18A/RPL22L1/MRPL38/RPS27L/MRPS23/MRPL37/MRPS17/MRPL39/MRPS9/RPL35/MRPL9/MRPS2/RPS19/MRPL49	-2.430715866175
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/2062	86/9376	0.528725779893082	SNTB1/ACTB/ITGA1/LEF1/ITGA4/DAG1/SGCE/ITGB7/ITGA3/CTNNB1	-2.33113563186148
Human Diseases	Substance dependence	hsa05034	Alcoholism	28/2062	191/9376	0.666582030357351	PPP1CA/MAPK1/KRAS/PRKACB/MAP2K1/HDAC9/HAT1/CALM3/PPP1CC/CREB1/HDAC2/SOS1/BRAF/GNGT2/ATF2/GNAI2/CALM1/HDAC8/HDAC7/HDAC5/HDAC3/GNB1/ATF6B/GNB5/GNAI3/SLC29A1/GNG5/MAOA	-2.47182998659796
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/2062	89/9376	0.510903562593315	CD47/ITGA1/HMMR/ITGA4/GP6/DAG1/ITGB7/ITGA3/THBS1/VTN	-2.46152511154951
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/2062	63/9376	0.433051591150524	LTC4S/PLAAT3/PLA2G6/TBXAS1/PTGIS/GGT5	-2.3972951386257
NA	NA	hsa04519	Cadherin signaling	67/2062	404/9376	0.754088599936618	RAC2/ARPC5L/VAV3/ACTN4/TMC8/PTK2B/CYFIP2/PPP1CA/MAPK1/KRAS/EVL/ACTR2/ACTB/KRT81/TMC6/APH1B/GSK3B/MAP2K1/EP300/MYO1E/ARPC1B/NFKB1/MYO1G/TAOK3/NCKAP1L/VASP/KRT86/RRAS2/WNT6/MAPK14/PPP1CC/YWHAH/LEF1/LATS1/ACTR3/MOB1A/ROCK1/ADAM10/MAP2K3/YWHAZ/MAPK8/ARPC2/PSENEN/MYO1F/VAV1/RYK/IKBKB/NF2/KRT23/CHUK/ARPC4/ARPC3/AFDN/APH1A/DVL3/WNT4/MPDZ/LIMD1/RHOA/RELA/AXIN1/NCSTN/CTNNB1/PCDH20/TAOK2/VANGL1/PSEN2	-2.682731466073
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	34/2062	233/9376	0.663516815625481	DIAPH1/LBR/LMNB1/FBN2/FMNL1/SNTB1/ATP1B3/ACTB/FMNL3/SUN2/DIAPH3/ITGA1/ATP1B1/TPM3/ENO1/CAPZB/ATP1A1/ITGA4/CSRP1/SYNE2/TTN/CAPZA1/DAG1/SGCE/PDLIM5/AMPD3/ITGB7/TLN2/LMNB2/MYH9/ITGA3/NID2/THBS1/SYNE3	-2.76152803601568
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	21/2062	160/9376	0.596799224054316	PTPRC/NCAM1/CD58/SPN/SELPLG/ITGAL/ITGAM/ICAM3/PECAM1/HLA-F/ICAM1/NECTIN3/ITGA4/CD2/GLG1/ITGB7/HLA-E/NFASC/F11R/CLDN4/HLA-A	-2.73125725661871
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/2062	31/9376	0.146678764744532	GUSB	-2.52671488086006
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/2062	66/9376	0.344472856597008	CYP3A5/HSD17B11/HSD17B7/SRD5A3/HSD11B1	-2.8375289241689
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/2062	88/9376	0.41336742791641	ITGAX/ITGAM/CD46/CLU/C3/SERPINE1/VTN/CFH	-2.93561363630795
Human Diseases	Immune disease	hsa05310	Asthma	1/2062	32/9376	0.142095053346266	FCER1G	-2.58107269763849
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/2062	103/9376	0.441460359910729	ATP1B3/SLC1A5/ATP1B1/ATP1A1/PRSS3/SLC3A2/CPA1/SLC1A1/CPB1/COL23A1	-3.02632087800804
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	35/2062	254/9376	0.626560865148888	ORAI2/PLCG2/PTK2B/CD38/SLC25A5/PPP3CC/ITPR1/STIM2/PRKACB/PPP3CA/NFATC2/VDAC3/PPP3R1/NFATC3/CALM3/STIM1/ADCY7/CAMK2G/PHKB/PLCB1/VDAC1/GNA15/PHKG2/CYSLTR1/CALM1/ITPR3/ADCY9/PHKA2/GNAQ/CAMK2D/PLCB2/ITPKB/TFEB/CAMK1D/ITPKC	-3.20364321420077
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/2062	70/9376	0.324788693362893	GSTP1/MGST2/CYP3A5/SULT1A3/HSD11B1	-3.01064599781085
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/2062	73/9376	0.249152970250987	GSTP1/MGST2/CYP3A5/MAOA	-3.41943125770274
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/2062	99/9376	0.321507999490541	SELPLG/ITGAL/ITGAM/ICAM1/KRT23/C3/CFH	-3.60338811115489
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/2062	68/9376	0.200604781194728	DHRS4L2/CYP3A5/DGAT1	-3.51269389664501
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/2062	79/9376	0.230229959852177	GSTP1/MGST2/CYP3A5/HSD11B1	-3.64800668040237
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/2062	86/9376	0.211490311957233	PRKACB/PLCB1/ITPR3/PLCB2	-3.90032586430775
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	35/2062	298/9376	0.534048522643683	TNFRSF18/XCL2/PRL/IL1RL1/CCR1/IL2RB/IL2RG/XCL1/TGFBR1/TGFB1/CSF1/RELL1/CXCR3/FASLG/TNFRSF4/TNFSF10/IFNAR2/OSM/TNFRSF1B/IL18/IL21R/CCL28/CCL3/IL27RA/RELT/TNFSF14/CCL8/IL1R2/IL4R/TNFRSF10A/TNFRSF21/CCL21/TNFSF13B/TNFRSF14/IL12RB1	-4.34016486177444
NA	NA	hsa04081	Hormone signaling	22/2062	219/9376	0.456780445460142	PRL/PRKACB/GNA13/ADIPOR2/PIK3CD/SMAD4/ADCY7/JAK2/GNGT2/PLCB1/GNA15/ADIPOR1/GNAI2/PIK3CB/GNB1/GNB5/GNAI3/ADCY9/GNAQ/RHOA/GNG5/PLCB2	-4.31890186534991
NA	NA	hsa04082	Neuroactive ligand signaling	13/2062	199/9376	0.297042925588174	PRKACB/ADCY7/GNGT2/PLCB1/GNAI2/GNB1/GNB5/GNAI3/ADCY9/GNAQ/GNG5/PLCB2/SLC1A1	-5.32178676308902
NA	NA	hsa04382	Cornified envelope formation	15/2062	217/9376	0.314311638738284	PPP2R2A/KRT81/PPP2R5A/KRT86/PPP2R1B/PPP2R5E/PPP2R5C/ELOVL1/UGCG/PPP2R3C/PPP2R2B/KRT23/PPP2CA/S100A1/CLDN4	-5.42606642460659
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/2062	143/9376	0.158987472275542	ACTN4/SNRPD1/SNRPD3/SNRPB/C3	-5.38085831579504
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/2062	370/9376	0.208918132487483	PRL/NR3C1/S1PR4/PTGDR/NMUR1/PTGER2/CYSLTR1/C3/PRSS3/UTS2/GAL/PTGER4/LPAR3/PGRMC2/LTB4R/CHRNA5/P2RY10	-8.24344626824965
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/2062	449/9376	0.0911433749748876	NCALD/GRK2/PRKACB/CALM3/CAMK2G/CALM1/GNB1/CAMK2D/ARRB2	-10.4789621357892