category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	32/1689	78/9376	2.27742101987217	PI4KA/ITPK1/PLCE1/ITPKC/PPIP5K2/MTMR3/IP6K3/PIP5K1A/PIK3C2A/FIG4/INPP5B/IMPA2/PLCD1/PIKFYVE/PLCD3/PIK3CB/PIP5K1C/SACM1L/PIK3C3/PLCB1/INPP4B/INPP4A/PIK3CD/MTM1/MTMR6/PTEN/PLCD4/SYNJ1/OCRL/PIK3CG/SYNJ2/PIP4K2C	5.31017227684531
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	72/1689	250/9376	1.59874955595027	GPR155/CTSD/DEPTOR/CTSW/CD68/NPC2/OSBPL3/CTSB/VPS41/VAMP8/CTSZ/ASAH1/AGA/GM2A/SLC29A1/DMXL1/BORCS7/ATP6V1H/GNPTAB/FIG4/ACP2/CLN5/IDS/SGSH/PIKFYVE/WDR7/CTSO/ATP6V1A/ATP6V0B/ACP5/SLC15A4/GALNS/DTNBP1/VPS16/ATP6AP1/HEXB/BORCS8/GNS/VPS13A/AP3S2/ATP6V0E1/GAA/MTOR/BORCS5/ARSB/GNPTG/MFSD8/SNAPIN/SNAP29/GGA2/SLC17A5/SLC38A9/AP3M1/TFEB/ATP6V0C/HEXA/MITF/VPS39/ATP6V1B2/TPP1/CLN8/ATP6V0D2/AP1B1/SORT1/VPS11/OSBPL2/ABCA5/AP3M2/AP5B1/MEAK7/TMEM175/AP4S1	4.49776746801874
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	35/1689	98/9376	1.98257633426372	PI4KA/ITPK1/PLCE1/ITPKC/PPIP5K2/MTMR3/IP6K3/PIP5K1A/CALM2/PIK3C2A/INPP5B/IMPA2/PLCD1/PIKFYVE/PLCD3/PIK3CB/DGKB/PIP5K1C/SACM1L/PIK3C3/PLCB1/INPP4B/INPP4A/PIK3CD/MTM1/MTMR6/PTEN/DGKH/PLCD4/SYNJ1/OCRL/SYNJ2/ITPR1/PIP4K2C/CALML4	4.58325663663076
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	42/1689	142/9376	1.64190828809446	HERC1/FBXW7/PIAS1/UBE2W/CBL/UBE4B/ITCH/RCHY1/FBXW11/ANAPC7/KLHL13/HERC3/UBA6/HERC4/UBE2K/UBE3C/SMURF1/ANAPC10/UBE2M/XIAP/UBE3B/ANAPC4/UBE2O/BIRC6/BTRC/CDC27/FBXW8/HUWE1/PRKN/ERCC8/NEDD4/CUL2/SKP1/BIRC3/CUL4A/TRAF6/DDB2/UBE2E3/CDC16/COP1/SYVN1/PIAS3	3.61280268254287
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	22/1689	63/9376	1.9385190823912	SETDB2/AASS/SMYD3/SETD2/NSD2/DHTKD1/ACAT2/BBOX1/KMT2E/SETD7/KMT5B/KMT2D/PLOD1/SMYD2/ALDH3A2/KMT2A/TMLHE/EZH1/NSD3/ALDH7A1/SETD1B/KMT5C	3.50340707774437
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	14/1689	34/9376	2.28579389126876	PER3/CRY2/NR1D1/RORB/PER1/CSNK1E/PRKAG1/FBXW11/CLOCK/DBP/FBXL3/BTRC/SKP1/PRKAA2	3.52056938179688
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	64/1689	250/9376	1.42111071640024	RAB11FIP1/TGFBR1/WIPF1/GRK5/PLD1/PDGFRA/GRK3/RAB31/PDCD6IP/EHD4/IL2RB/ASAP2/SMAP2/SMAD2/SNX4/SMAP1/ZFYVE16/CBL/VPS37B/PIP5K1A/WASHC1/RABEP1/ITCH/ARPC1B/RAB11FIP3/WASHC4/TFRC/FOLR2/PIP5K1C/SMURF1/VPS45/HSPA1B/GBF1/HLA-E/LDLR/VPS37A/SNX5/DNM2/GIT2/CAPZA1/CHMP5/GRK4/STAMBP/ARFGEF1/AGAP5/MVB12B/ARF4/EPN2/DNAJC6/CAV2/CYTH3/PARD6B/NEDD4/IL2RA/TRAF6/HSPA1A/ARRB2/EPS15L1/PARD3/ARFGAP1/KIF5C/EGFR/ARAP3/FOLR1	3.1633561341904
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	30/1689	100/9376	1.66536412078153	CCL3/CCL8/CCL4/XCL2/XCL1/CCL23/IL2RB/CCL2/CXCL14/CCL5/CSF1R/CCL21/IL10RB/TNFRSF1B/IL18/CCL14/LTBR/CSF1/IL18R1/IL2RA/CCL28/TNFSF10/IL20RB/TNFSF14/CXCL13/ACKR4/CCL13/IL34/CXCR3/TNFRSF10A	3.13545831011836
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	28/1689	93/9376	1.67133316780942	TGFBR1/SORBS1/NECTIN2/PTPRJ/CTNND1/ROCK2/RAC2/RAP1A/LMO7/AFDN/INSR/RAP1B/EP300/ACTN1/TJP1/SMURF1/NLK/KRIT1/CSNK2A1/WASF2/WASF1/PTPN6/MYL12A/TCF7L2/PARD3/LEF1/EGFR/WASF3	3.04970214994082
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	18/1689	52/9376	1.92157398551715	APOA1/SCARB1/NPC2/APOC3/SOAT1/APOC1/STARD3NL/SOAT2/APOC2/NCEH1/LDLR/ANGPTL4/CYP27A1/CD36/STARD3/TSPO/SORT1/LPL	3.12358097294772
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	42/1689	157/9376	1.48503806948671	TGFBR1/NKD1/WNT4/WNT6/DLG5/WNT5A/CRB2/SERPINE1/ID1/TEAD1/WNT9A/SMAD2/WNT3/DLG1/AREG/PPP1CB/PATJ/CSNK1E/APC/FBXW11/GLI2/PPP2R1B/WNT9B/MOB1B/DLG2/WNT5B/BTRC/LATS1/CCND3/WNT10B/PARD6B/BMP8A/BIRC3/CRB1/PPP2R2B/NKD2/TCF7L2/PARD3/BMP4/LEF1/WWC1/WNT1	2.87280248542027
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	31/1689	108/9376	1.59340394272307	KPNA1/RANBP2/RANGAP1/NUP160/KPNA6/AHCTF1/XPO1/XPO4/RANBP17/TMEM33/UPF2/POM121/NUP210L/XPO7/UPF3B/KPNA3/NUP210/NUP214/CASC3/NUP42/THOC2/NUP133/NUP155/NUP93/CSE1L/NDC1/ALYREF/NUP85/AAAS/KPNA5/NUP35	2.90730981986708
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	11/1689	27/9376	2.26160559612306	HACD1/TECR/ELOVL1/HACD2/HSD17B12/ACOT7/SCD5/ACOX3/ELOVL6/HACD4/ELOVL4	3.07712353128138
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	31/1689	110/9376	1.56443296194628	TGFBR1/SMAD6/ID3/SMAD9/ID1/SMAD2/SKI/ZFYVE16/CHRD/NCOR1/SKIL/TFRC/EP300/LTBP1/PPP2R1B/BAMBI/SMURF1/ACVR2A/LEMD3/DCN/NEO1/RGMB/ACVR1C/BMP8A/SKP1/LEFTY2/HFE/GREM2/ACVR1B/BMP4/FST	2.79115905117687
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	44/1689	169/9376	1.44528641645734	CTSD/DEPTOR/ATG9B/MTMR3/CTSB/VPS41/VAMP8/NBR1/MRAS/UVRAG/RAB1A/SUPT20H/ATG2B/RHEB/DAPK2/PIK3CB/STX7/VPS16/EPG5/TANK/ATG5/EIF2AK4/PIK3C3/MTOR/PIK3CD/GABARAPL2/BIRC6/PTEN/SNAP29/IRS2/HIF1A/ATG14/TRAF6/BCL2L1/VPS39/IRS1/TSC1/ATG4A/VPS11/PRKAA2/SQSTM1/ITPR1/ATG4D/WDFY3	2.73807758706588
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	7/1689	14/9376	2.77560686796921	B3GNT2/ST3GAL1/CHST1/B4GALT4/B4GALT3/B3GNT7/ST3GAL2	3.1163665783253
NA	NA	hsa04517	IgSF CAM signaling	71/1689	299/9376	1.31818118813254	UNC5B/MPDZ/NFASC/SORBS1/PPFIA1/NECTIN2/NCAM1/PTPRD/MAPK14/FOXO1/MYLK3/NCK1/KCNA4/UNC5C/SRGAP3/LCP2/CD96/VAV3/CLMP/RAP1A/PVR/CADM1/TRPC6/ROBO2/LMO7/AFDN/EZR/DOK2/CABLES1/RAP1B/MYH10/ARPC1B/TUBA3E/MTSS2/CDH2/RASA1/ERC1/ANK3/TUBA4A/PIK3CB/NLGN4X/PLXNA4/ACTN1/TJP1/MYLK/RAPGEF6/EPB41L1/LRFN4/MAGI2/CD2/PIK3CD/PARD6B/BCAR1/SH2D1B/KCNQ3/PTPN6/TRAF6/MYL12A/SCN8A/NLGN2/KDR/NRCAM/PTK2/SPTBN4/PLXNA2/PARD3/LYN/CD84/LRRTM4/IGSF5/PAK4	2.62096335023544
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	18/1689	56/9376	1.78431870083735	ST6GAL2/ST6GAL1/MGAT5/TUSC3/MAN1A2/ALG14/ALG13/ALG9/RPN2/STT3B/B4GALT3/STT3A/MGAT4A/MAN1A1/RPN1/MAN1B1/ALG6/SRD5A3	2.75931098545921
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	13/1689	36/9376	2.00460496019999	ST6GALNAC3/GALNT18/GALNT17/GCNT1/C1GALT1/GALNT15/B4GALT5/ST6GALNAC2/ST3GAL1/C1GALT1C1/GALNT6/ST3GAL2/GALNT3	2.8307085251807
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	28/1689	99/9376	1.57004024854824	PLPP3/PLD1/PDGFRA/PDGFD/CHPT1/RAC2/SLC44A2/PIP5K1A/SLC44A1/RHEB/PDGFC/PIK3CB/DGKB/PIP5K1C/LYPLA1/SLC44A3/MTOR/PIK3CD/PLPP1/WASF2/WASF1/DGKH/HIF1A/TSC1/SLC22A5/EGFR/WASF3/SLC44A5	2.67264552777119
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	50/1689	200/9376	1.38780343398461	WIPF1/MYO10/ABI1/MAPK14/MYO1D/NCK1/LPAR1/CLDN4/F2R/ROCK2/MYO1B/CLDN20/MYO5A/SEC24B/EZR/RAB1A/MYH10/ARPC1B/IKBKB/TUBA3E/TUBA4A/GNA13/IL18/IRAK4/TJP1/CLDN10/TMBIM6/TAB2/TMED10/CLDN3/WASF2/WASF1/OCLN/CLDN5/CLDN12/CYTH3/CYFIP2/ARHGEF11/PTPN6/TRAF6/FAS/CHUK/TNFSF10/SEC24C/CLDN23/WASF3/MYO1G/CASP9/TIRAP/TNFRSF10A	2.59849549519012
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	15/1689	44/9376	1.89245922816083	TUSC3/MAN1A2/ALG14/ALG13/ALG9/HEXB/RPN2/STT3B/B4GALT3/STT3A/MGAT4A/MAN1A1/RPN1/MAN1B1/HEXA	2.78130989069142
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	44/1689	174/9376	1.40375519759362	MAP3K5/AMFR/SIL1/SEC24B/DERL1/ERLEC1/HSPH1/UBE4B/WFS1/UBXN2A/TUSC3/MAN1A2/MBTPS2/SEC23A/HSPA1B/RPN2/UGGT2/SEC23B/STT3B/STT3A/RAD23A/PPP1R15A/BCAP31/MAN1A1/SEL1L/RPN1/PRKN/RAD23B/SSR1/UGGT1/MAN1B1/SKP1/DNAJC5/ATF6B/RNF185/MAP2K7/HSPA1A/SEC24C/SYVN1/SVIP/FBXO6/DERL3/SEC61A2/CRYAB	2.5198440184496
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	24/1689	83/9376	1.60517023689786	SCMH1/JARID2/ASXL2/RBBP4/EP300/MGA/FOXK2/KDM2A/PCGF6/L3MBTL1/SCML1/PHC3/EED/SKP1/MBD6/EZH1/BCORL1/L3MBTL4/SFMBT1/SCML2/L3MBTL2/USP45/CBX7/E2F6	2.59573683915759
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	48/1689	193/9376	1.38061274261681	GRK5/CCL3/RASGRP2/CCL8/CCL4/GRK3/XCL2/XCL1/CCL23/ITK/ROCK2/ADCY9/VAV3/RAC2/RAP1A/GNB5/CCL2/GNGT1/TIAM1/CXCL14/CCL5/CCL21/RAP1B/IKBKB/PIK3CB/CCL14/STAT2/GNG2/PLCB1/PIK3CD/GNG7/ADCY7/GRK4/ADCY2/PIK3R6/BCAR1/CCL28/CHUK/PIK3CG/ARRB2/PTK2/CXCL13/PARD3/LYN/JAK2/GNGT2/CCL13/CXCR3	2.50433088092431
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	50/1689	203/9376	1.36729402363015	ITGA1/LAMA4/PARVA/COL4A6/ITGA3/PDGFRA/TLN2/PDGFD/LAMC3/COL4A5/MYLK3/VTN/EMP2/ROCK2/VAV3/RAC2/ITGA6/RAP1A/PIP5K1A/PPP1CB/ITGB5/VEGFA/RAP1B/PDGFC/PIK3CB/ACTN1/MYLK/PIP5K1C/FLNB/XIAP/THBS4/PARVB/ARHGAP5/PIK3CD/COL4A4/PTEN/CCND3/CAV2/BCAR1/COL4A3/BIRC3/MYL12A/PARVG/LAMB3/KDR/PTK2/RELN/EGFR/PAK4/LAMA3	2.47986595556303
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	26/1689	93/9376	1.5519522272516	LAMA4/COL4A6/ITGA3/LAMC3/COL4A5/ITGA6/POLK/FHIT/IKBKB/PIK3CB/XIAP/PIK3CD/COL4A4/PTEN/COL4A3/BIRC3/TRAF6/BCL2L1/TRAF1/CHUK/LAMB3/DDB2/PTK2/CASP9/RARB/LAMA3	2.50738377727778
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	8/1689	19/9376	2.33735315197407	IDS/SGSH/GALNS/HEXB/GNS/ARSB/HEXA/HPSE	2.73512143960528
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	19/1689	63/9376	1.67417557115603	WNT4/WNT6/WNT5A/WNT9A/SUFU/WNT3/POLK/APC/GLI3/GLI2/WNT9B/WNT5B/WNT10B/TCF7L2/DDB2/KIF7/BMP4/LEF1/WNT1	2.51663659476441
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	40/1689	158/9376	1.40537056606036	WNT4/WNT6/CAB39L/DEPTOR/WNT5A/SGK1/RPS6KA2/WNT9A/CAB39/WNT3/ATP6V1H/INSR/IKBKB/LPIN1/RHEB/ATP6V1A/PIK3CB/PRR5L/STRADB/RICTOR/WNT9B/NPRL3/MTOR/PIK3CD/WNT5B/PTEN/DEPDC5/SLC38A9/WNT10B/PRR5/WDR59/ATP6V1B2/IRS1/CHUK/TSC1/PRKAA2/LRP5/RPS6KA1/WNT1/FLCN	2.40870949959278
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	76/1689	333/9376	1.26694367546943	MAML3/ITGA1/WNT4/WNT6/LAMA4/WNT5A/COL4A6/ITGA3/LFNG/ISG15/LAMC3/COL4A5/FOXO1/VTN/WNT9A/MX1/ITGA6/WNT3/DLG1/NFX1/ATP6V1H/ITGB5/VEGFA/PATJ/IKBKB/IFNAR2/APC/RHEB/PPP2R3C/EP300/ATP6V1A/ATP6V0B/PIK3CB/EIF2AK2/PPP2R1B/STAT2/WNT9B/ATP6AP1/HLA-E/ATP6V0E1/THBS4/DLG2/MTOR/PIK3CD/WNT5B/BCAP31/COL4A4/IRF9/PTEN/CCND3/RBL2/WNT10B/PARD6B/ATP6V0C/COL4A3/FAS/CREB3L1/ATP6V1B2/PPP2R2B/PTGER4/CHUK/TSC1/LAMB3/ATP6V0D2/PPP2R3A/OASL/TCF7L2/TUBG2/PTK2/RELN/PARD3/HES4/EGFR/HEYL/WNT1/LAMA3	2.32491730260558
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	17/1689	55/9376	1.71582970019915	PLPP3/CERK/CERS6/ASAH1/GM2A/SPTLC2/SGPL1/SPTLC1/B4GALT5/SAMD8/HEXB/PLPP1/HEXA/CERS4/B4GALT6/ACER1/GBA2	2.49563936162214
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	51/1689	212/9376	1.33543349307953	CNR1/RASGRP2/PDGFRA/TLN2/PDGFD/SIPA1L2/DOCK4/MAPK14/SKAP1/LPAR1/PLCE1/CTNND1/LCP2/ID1/F2R/ADCY9/VAV3/RAC2/SIPA1L1/RAP1A/PRKD1/TIAM1/EPHA2/MRAS/FYB1/AFDN/INSR/CALM2/VEGFA/CSF1R/RAP1B/PDGFC/PIK3CB/RAPGEF6/ANGPT1/MAGI2/PLCB1/TEK/PIK3CD/ADCY7/KRIT1/ADCY2/CSF1/PARD6B/BCAR1/KDR/PARD3/RGS14/EGFR/ARAP3/CALML4	2.31554826313285
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	21/1689	73/9376	1.59692449937955	BST2/MDFIC/PDCD6IP/BICD1/SMARCB1/RANBP2/MX1/KAT2B/XPO1/SAMHD1/PIN1/EP300/CCNT2/SERINC5/SERINC3/CPSF6/NELFA/APOBEC3G/BICD2/MLLT3/MAP1S	2.39989005419028
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	42/1689	170/9376	1.37147633476126	MPDZ/MAP3K5/CLDN4/ROCK2/CLDN20/RAP1A/DLG1/RUNX1/TIAM1/SYNPO/AFDN/EZR/MYH10/PATJ/ARPC1B/PRKAG1/TUBA3E/TUBA4A/PPP2R1B/ACTN1/TJP1/CLDN10/RAPGEF6/DLG2/CLDN3/CD1D/OCLN/CLDN5/CLDN12/PARD6B/NEDD4/PRKCE/ARHGAP17/MYL12A/PPP2R2B/WHAMM/CGN/MAP2K7/PRKAA2/PARD3/CLDN23/IGSF5	2.29108999982292
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/1689	20/9376	2.22048549437537	TM7SF2/SOAT1/SOAT2/FDFT1/HSD17B7/LSS/DHCR7/DHCR24	2.56108820402637
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	15/1689	48/9376	1.73475429248076	HIBADH/AUH/MCCC1/HIBCH/ACAT2/MCEE/OXCT1/ACADM/ALDH3A2/ACSF3/BCAT2/DBT/ALDH7A1/PCCB/ACADSB	2.39216154347183
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	30/1689	116/9376	1.43565872481166	MMP9/THY1/MAPK14/CTNND1/CLDN4/ITK/ROCK2/CLDN20/VAV3/RAC2/RAP1A/RHOH/AFDN/EZR/RAP1B/TXK/PIK3CB/ACTN1/CLDN10/ARHGAP5/PIK3CD/CLDN3/OCLN/CLDN5/CLDN12/BCAR1/MYL12A/CYBA/PTK2/CLDN23	2.21305363584775
NA	NA	hsa04518	Integrin signaling	38/1689	154/9376	1.36978001276403	ITGA1/LAMA4/PARVA/COL4A6/ITGA3/FERMT2/PDGFRA/TLN2/PDGFD/LAMC3/COL4A5/ITGAD/LIMS2/VTN/C3/FREM1/RAC2/ITGA6/ITGB5/VEGFA/PDGFC/PIK3CB/ACTN1/FLNB/THBS4/PARVB/MTOR/PIK3CD/COL4A4/CCND3/COL4A3/PARVG/LAMB3/KDR/PTK2/RELN/EGFR/LAMA3	2.16876880096887
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	43/1689	178/9376	1.34102354295142	LGR4/NKD1/WNT4/WNT6/DAAM1/WNT5A/TLE2/ROCK2/WNT9A/RAC2/WNT3/MCC/TLE6/CSNK1E/APC/FBXW11/EP300/CAMK2G/DAAM2/CCDC88C/BAMBI/WNT9B/NLK/PPP3CB/DKK1/PLCB1/INVS/WNT5B/CSNK2A1/BTRC/CHD8/PPP3CC/CELSR1/CCND3/WNT10B/CTNNBIP1/SKP1/TBL1X/NKD2/TCF7L2/LRP5/LEF1/WNT1	2.15312717865414
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	48/1689	204/9376	1.30616793786786	WNT4/WNT6/MMP9/WNT5A/ESR1/MAPK14/PLCE1/VTN/PLAUR/ROCK2/WNT9A/VAV3/ERBB3/SMAD2/WNT3/TIMP3/LUM/CBL/TIAM1/MRAS/PPP1CB/EZR/ITGB5/VEGFA/SDC1/ANK3/PIK3CB/CAMK2G/WNT9B/IGF2/DROSHA/MTOR/DCN/PIK3CD/WNT5B/SDC2/CAV2/WNT10B/HIF1A/PTPN6/FAS/KDR/HOXD10/PTK2/ITPR1/HPSE/EGFR/WNT1	2.07235804906044
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	28/1689	109/9376	1.42599985877317	FOXO1/TBC1D4/RPS6KA2/ACACB/PPP1CB/INSR/PRKAG1/IKBKB/PYGL/OGA/PIK3CB/GFPT1/SLC27A6/MTOR/PIK3CD/PTEN/IRS2/CD36/PRKCE/CREB3L1/IRS1/PRKAA2/G6PC3/PYGM/SLC27A2/RPS6KA1/GYS1/PPP1R3C	2.09688756883383
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/1689	30/9376	1.85040457864614	ABCC1/MTR/ABCC3/IKBKB/FPGS/FOLR2/CHUK/SLC46A1/FOLR1/TYMS	2.18673094730557
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	79/1689	362/9376	1.21145272137883	PRL/PRLR/ITGA1/LAMA4/COL4A6/ITGA3/PDGFRA/PDGFD/LAMC3/COL4A5/SGK1/LPAR1/VTN/NTRK1/IL2RB/CSF3R/F2R/ERBB3/ITGA6/GHR/AREG/GNB5/GNGT1/EPHA2/INSR/ITGB5/VEGFA/CSF1R/IKBKB/IFNAR2/RHEB/IL7/PPP2R3C/PDGFC/PIK3CB/PPP2R1B/IGF2/ANGPT1/GNG2/MAGI2/THBS4/OSM/MTOR/TEK/PIK3AP1/PIK3CD/GNG7/RET/COL4A4/PIK3R6/CSF1/PTEN/CCND3/RBL2/COL4A3/IL2RA/ATF6B/BCL2L1/CREB3L1/PPP2R2B/IRS1/CHUK/PHLPP2/TSC1/LAMB3/PIK3CG/KDR/PPP2R3A/PRKAA2/MTCP1/PTK2/RELN/G6PC3/JAK2/EGFR/GNGT2/GYS1/CASP9/LAMA3	1.92322816164872
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	16/1689	56/9376	1.58606106741098	GRK3/SUFU/GAS1/DISP1/CSNK1E/GLI3/FBXW11/GLI2/SMURF1/BTRC/GPR161/ARRB2/IQCE/KIF7/SPOPL/CDON	2.06182096605703
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	36/1689	149/9376	1.34123284895157	PLPP3/PLD1/PDGFRA/PDGFD/GRM7/LPAR1/FCER1G/F2R/ADCY9/MRAS/PIP5K1A/INSR/RHEB/MS4A2/PDGFC/PIK3CB/DGKB/GNA13/PIP5K1C/PLCB1/DNM2/MTOR/PIK3CD/AGPAT2/ADCY7/ADCY2/PIK3R6/PLPP1/DGKH/CYTH3/GAB2/TSC1/PIK3CG/AVPR1A/EGFR/PTGFR	1.96804818996969
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	43/1689	184/9376	1.29729451437691	SEMA3A/SEMA3B/WNT4/UNC5B/SEMA6D/WNT5A/ABLIM3/ABLIM2/NCK1/SEMA3C/SEMA4D/DPYSL2/UNC5C/SEMA6A/SEMA7A/SRGAP3/ROCK2/RAC2/TRPC6/ROBO2/EPHA2/RASA1/PIK3CB/CAMK2G/PLXNA4/LIMK2/PPP3CB/SSH1/PIK3CD/WNT5B/NEO1/PPP3CC/SEMA4A/PARD6B/LRIG2/MYL12A/PTK2/SEMA3G/PLXNA2/PARD3/EPHB6/PAK4/SEMA3E	1.90903030146029
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/1689	15/9376	2.22048549437537	ST6GALNAC3/ST3GAL5/ST3GAL1/HEXB/HEXA/ST3GAL2	2.21737502435077
NA	NA	hsa03272	Virion - Hepatitis viruses	14/1689	48/9376	1.61910400631537	SCARB1/PDCD6IP/CLDN4/CLDN20/CD81/CLDN10/LDLR/CLDN3/OCLN/CLDN5/CLDN12/SLC10A1/CLDN23/EGFR	2.01563544503656
NA	NA	hsa04981	Folate transport and metabolism	10/1689	31/9376	1.79071410836723	ABCC1/MTR/ABCC3/FPGS/MTHFS/BHMT2/FOLR2/SLC46A1/FOLR1/TYMS	2.06696300839958
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	22/1689	85/9376	1.43678473165465	UPP1/CDA/PNP/NUDT16/ENPP1/ENPP3/ENTPD1/ENTPD3/CMPK1/AK3/AK9/ENTPD5/AK6/AMPD3/AK1/ADA2/NT5C3A/ADK/NME7/CMPK2/AK5/TYMS	1.89612822906186
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	14/1689	49/9376	1.58606106741098	LFNG/ST6GAL2/GALNT18/GALNT17/ST6GAL1/C1GALT1/EOGT/GALNT15/GXYLT1/B4GALT3/POMT2/C1GALT1C1/GALNT6/GALNT3	1.92793303866973
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	17/1689	63/9376	1.49794656366592	CCNH/MNAT1/POLR2K/XPC/POLR2A/POLE4/POLR2J/RAD23A/POLR2J3/GTF2H5/ERCC8/RAD23B/CUL4A/ERCC3/DDB2/RFC3/GTF2H2C	1.8587896061111
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/1689	28/9376	1.78431870083735	HACD1/TECR/ELOVL1/HACD2/HSD17B12/ACOT7/ELOVL6/HACD4/ELOVL4	1.94820321840814
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	16/1689	59/9376	1.50541389449178	UPP1/CDA/NUDT2/ENPP1/ENPP3/ENTPD1/ENTPD3/CMPK1/AK9/CDADC1/ENTPD5/DPYD/NT5C3A/NME7/CMPK2/TYMS	1.82539626512391
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/1689	50/9376	1.55433984606276	SAT1/MAOB/MAOA/ARG1/SMOX/P4HA3/PYCR2/ODC1/ALDH3A2/CKB/CKMT2/ALDH7A1/ALDH18A1/GOT2	1.842194222576
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	30/1689	125/9376	1.33229129662522	CTSD/MAP3K5/PLD1/MAPK14/FCER1G/CERS6/ABCC1/ROCK2/RAC2/ASAH1/SPTLC2/SGPL1/SPTLC1/MS4A2/ORMDL1/PPP2R3C/ORMDL2/PIK3CB/GNA13/PPP2R1B/PLCB1/PIK3CD/PTEN/PRKCE/GAB2/CERS4/PPP2R2B/PPP2R3A/ACER1/SPTSSB	1.75307967599901
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	36/1689	155/9376	1.28931415802441	WNT4/WNT6/WNT5A/SCARB1/KCNA4/WNT9A/ADCY9/WNT3/RAP1A/CACNA1G/CDKN2C/PDE8A/RAP1B/APC/CAMK2G/WNT9B/NCEH1/LDLR/PLCB1/WNT5B/KMT2D/ADCY7/ADCY2/ARNT/KCNK3/WNT10B/KMT2A/ATF6B/RBBP5/CREB3L1/TCF7L2/ARMC5/ITPR1/LEF1/EGFR/WNT1	1.70242719244501
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	38/1689	166/9376	1.27075977087747	ATP2B4/KCNMA1/MYLK3/KCNMB4/ROCK2/EDNRB/ADCY9/TRPC6/MEF2A/PPP1CB/INSR/CALM2/PDE3A/SLC25A4/GNA13/MYLK/ATP2B3/PPP3CB/PLCB1/KCNJ8/ADCY7/ADCY2/PIK3R6/KCNMB2/FXYD2/NPR1/PPP3CC/ATP1B3/IRS2/PRKCE/ATF6B/CREB3L1/IRS1/PIK3CG/PLN/ITPR1/RGS2/CALML4	1.6497965431705
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	29/1689	122/9376	1.31955080608372	CAB39L/FOXO1/CAB39/ACACB/INSR/LEPR/PRKAG1/ADIPOR1/RHEB/PPP2R3C/PIK3CB/STRADB/PPP2R1B/MTOR/PIK3CD/IRS2/CD36/EEF2K/SCD5/CREB3L1/PPP2R2B/IRS1/TSC1/PPP2R3A/PRKAA2/G6PC3/FBP1/MLYCD/GYS1	1.6652410478742
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	17/1689	65/9376	1.45185590016851	PLPP3/LCLAT1/LPIN1/PNPLA2/DGKB/PLPP5/AGPAT2/PLPP1/GK/DGKH/ALDH3A2/MBOAT2/AGK/ALDH7A1/DGAT2/LPL/GPAM	1.71348574186088
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	11/1689	38/9376	1.60693029198218	BST1/PNP/ENPP1/ENPP3/NUDT12/NMNAT3/NMRK1/SIRT7/NADSYN1/SIRT6/SIRT2	1.75721822820238
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	6/1689	17/9376	1.9592519068018	MTR/KYAT1/TXNRD2/PAPSS1/TXNRD3/INMT	1.85551483390488
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1689	34/9376	1.63270992233483	POLR2K/POLR3GL/POLR2A/POLR3B/POLR2J/POLR1A/POLR2J3/POLR3A/POLR3E/POLR3C	1.73239210052016
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	31/1689	133/9376	1.29389192341422	KLRD1/KLRC1/GZMB/TYROBP/KLRC2/FCER1G/CD247/KLRC3/HCST/LCP2/PRF1/VAV3/RAC2/KLRK1/IFNAR2/KIR2DL4/PIK3CB/PPP3CB/HLA-E/ZAP70/PIK3CD/KIR2DL1/IFNGR1/PPP3CC/SH2D1B/PTPN6/FAS/TNFSF10/ULBP2/NCR1/TNFRSF10A	1.60003328629685
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	38/1689	168/9376	1.25563167836702	PRL/PRLR/PDGFRA/STAT4/IL2RB/CSF3R/PIAS1/GHR/LEPR/IL15/IFNAR2/IL7/IL10RB/EP300/PIK3CB/IL13RA1/STAT2/OSM/MTOR/PIK3CD/IRF9/IFNGR1/SOCS5/CSF2RB/CCND3/CLCF1/CISH/LIFR/IL2RA/PTPN6/BCL2L1/SOCS7/IL20RB/JAK2/EGFR/PIAS3/IL21R/CSF2RA	1.56714318864441
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	15/1689	57/9376	1.4608457199838	HACD1/CBR4/TECR/ACAT2/ACADM/ELOVL1/HACD2/ACSF3/HSD17B12/SCD5/ACOX3/ELOVL6/ACADSB/HACD4/ELOVL4	1.63580056115618
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	16/1689	62/9376	1.43257128669379	FOXO1/ADCY9/INSR/PRKAG1/PIK3CB/ATG5/HSPA1B/MTOR/PIK3CD/ADCY7/ADCY2/IRS2/IRS1/PRKAA2/HSPA1A/CRYAB	1.60179686291909
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	32/1689	140/9376	1.26884885392878	TGFBR1/SERPINE1/PLIN1/MYLK3/KLF2/ADCY9/SMAD2/GNB5/MEF2A/GNGT1/HDAC4/MRAS/CALM2/PRKAG1/GNA13/MYLK/GNG2/PIK3C3/PLCB1/ACTA2/MTOR/GNG7/ADCY7/ADCY2/PIK3R6/PRKCE/PIK3CG/RYR2/PRKAA2/ITPR1/GNGT2/CALML4	1.5022847810712
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	27/1689	116/9376	1.2920928523305	SLC1A1/PLD1/HOMER2/GRK3/GRM7/SLC38A1/ADCY9/SLC1A2/GNB5/GRIK2/GNGT1/HOMER1/GRIK1/GLUL/SLC38A2/PPP3CB/GNG2/PLCB1/GNG7/ADCY7/ADCY2/PPP3CC/GRIN2D/SHANK2/GRIA4/ITPR1/GNGT2	1.48376954721748
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	63/1689	298/9376	1.17357874283262	PRL/TGFBR1/PRLR/IL1RL1/TNFRSF21/CCL3/CCL8/TNFRSF8/IL1R2/CCL4/XCL2/XCL1/CCL23/TNFRSF18/IL2RB/CSF3R/GHR/CCL2/CXCL14/CCL5/INHA/LEPR/CSF1R/CCL21/IL15/IFNAR2/IL7/IL10RB/TNFRSF1B/IL18/IL13RA1/CCL14/LTBR/TNFSF13B/ACVR2A/OSM/TNFRSF4/IFNGR1/CSF2RB/CSF1/CLCF1/ACVR1C/BMP8A/TNFRSF19/LIFR/IL18R1/IL2RA/FAS/CCL28/TNFSF10/IL20RB/TNFSF14/ACVR1B/CXCL13/BMP4/ACKR4/CCL13/IL34/CXCR3/TNFRSF10A/IL21R/CSF2RA/IL36G	1.42735369584376
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	26/1689	112/9376	1.28867461727142	LAMA4/HLA-DRB1/LAMC3/MAPK14/HLA-DMA/ITGA6/IKBKB/IL10RB/IRAK4/HSPA1B/LDLR/XIAP/TAB2/PIK3R6/IFNGR1/BIRC3/TRAF6/BCL2L1/CHUK/LAMB3/PIK3CG/HSPA1A/JAK2/HLA-DMB/CASP9/LAMA3	1.44058987904301
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	35/1689	157/9376	1.23753172457226	GULP1/ARG1/MAPK14/SGK1/ATP11A/XKR6/VPS41/ADAM10/C1QB/MFGE8/ITGB5/ADAM9/MERTK/CAMK2G/VPS16/PROS1/ATP8A2/VPS8/AXL/ODC1/ARNT/TYRO3/CD36/BCAR1/HIF1A/PTPN6/VPS39/PTGER4/GPR132/VPS11/ATP8A1/PTK2/ANO4/JAK2/XKR8	1.40686220658819
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	32/1689	142/9376	1.25097774331007	MMP9/MAP3K5/MAPK14/IL1R2/MGST2/KLF2/RAC2/MAPK7/MEF2A/CCL2/CALM2/VEGFA/IKBKB/SDC1/PIK3CB/MGST1/ACVR2A/GSTA1/PIK3CD/SDC2/CAV2/CHUK/MAP2K7/ASS1/KDR/PRKAA2/CYBA/PTK2/SQSTM1/BMP4/CALML4/SELE	1.41255858680505
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	7/1689	23/9376	1.68949983267691	LARGE1/CRPPA/B4GALT3/POMT2/B3GAT2/B3GALNT2/POMGNT2	1.5518317687691
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	29/1689	128/9376	1.25769686204855	PDE4B/ADCY9/PNP/NUDT2/NUDT16/ENPP1/FHIT/ENPP3/PDE8A/ENTPD1/ENTPD3/PDE3A/PDE1A/AK3/AK9/ENTPD5/AK6/ADCY7/ADCY2/AMPD3/AK1/PAPSS1/NPR1/ADA2/ENPP4/NUDT5/ADK/NME7/AK5	1.37598033432337
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	39/1689	180/9376	1.20276297611999	BST2/NECTIN2/HLA-DRB1/CD74/HLA-DMA/C3/B2M/CCL2/PPP1CB/CCL5/IFIH1/IKBKB/IFNAR2/RHEB/OAS3/PIK3CB/EIF2AK2/IRAK4/STAT2/HLA-E/MTOR/TAB2/PIK3CD/IRF9/IFNGR1/IRF7/HCFC2/BIRC3/TRAF6/FAS/BCL2L1/CHUK/TSC1/TNFSF14/ALYREF/JAK2/HLA-DMB/PILRB/CASP9	1.28750063171681
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	46/1689	216/9376	1.18220292524615	APOA1/MMP9/CCL3/MAP3K5/MAPK14/ROCK2/VAV3/RAP1A/CCL2/CCL5/CALM2/HSPA2/RAP1B/IKBKB/PIK3CB/IL18/CAMK2G/IRAK4/TANK/HSPA1B/PPP3CB/LDLR/PLCB1/TAB2/PIK3CD/MIB1/IRF7/PPP3CC/CD36/TRAF6/FAS/BCL2L1/CHUK/MAP2K7/TNFSF10/HSPA1A/CYBA/PTK2/ITPR1/LYN/JAK2/CALML4/SELE/CASP9/TIRAP/TNFRSF10A	1.26986193886934
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	35/1689	160/9376	1.21432800473653	NFASC/NECTIN2/NCAM1/HLA-DRB1/PTPRD/PTPRC/HLA-DMA/CLDN4/CLDN20/ITGA6/PVR/CADM1/SDC1/CDH2/NRXN1/NLGN4X/CLDN10/SPN/HLA-E/CD2/SELPLG/CLDN3/ALCAM/NEO1/OCLN/CLDN5/SDC2/CLDN12/CD58/NLGN2/NRCAM/SIGLEC1/CLDN23/HLA-DMB/SELE	1.28170979038237
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	22/1689	95/9376	1.28554423358574	CCL3/HLA-DRB1/HLA-DMA/CCL2/ATP6V1H/CCL5/VEGFA/IL15/ATP6V1A/ATP6V0B/ACP5/IL18/TNFSF13B/ATP6AP1/ANGPT1/ATP6V0E1/TEK/CSF1/ATP6V0C/ATP6V1B2/ATP6V0D2/HLA-DMB	1.31117250320106
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	24/1689	105/9376	1.26884885392878	ATG9B/CITED2/CCZ1B/AMFR/USP15/NBR1/MRAS/MTX2/SMURF1/GABARAPL2/RHOT1/CSNK2A1/MFN2/FUNDC1/HUWE1/PRKN/TFEB/HIF1A/MITF/BCL2L1/USP30/MON1A/SQSTM1/CCZ1	1.29855865418384
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/1689	33/9376	1.51396738252866	VAMP8/VAMP2/VAMP4/STX7/SNAP23/STX16/SNAP29/VAMP1/STX6	1.38634517923735
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	17/1689	71/9376	1.32916385226695	MAPK14/ADAM10/ATP6V1H/CCL5/IKBKB/ATP6V1A/ATP6V0B/TJP1/ATP6AP1/ATP6V0E1/ATP6V0C/ATP6V1B2/CHUK/ATP6V0D2/LYN/EGFR/IGSF5	1.30498387208731
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	50/1689	238/9376	1.16622137309631	RASGRP2/RGL1/PLD1/PDGFRA/PDGFD/ETS2/PLCE1/NTRK1/RALGAPB/RAC2/RAP1A/RASA2/GNB5/GNGT1/TIAM1/EPHA2/MRAS/AFDN/INSR/CALM2/VEGFA/CSF1R/RAP1B/IKBKB/RASA1/PDGFC/PIK3CB/RALGAPA1/IGF2/ANGPT1/GNG2/TEK/RASA3/ZAP70/PIK3CD/STK4/GNG7/RALBP1/RASAL3/CSF1/GAB2/BCL2L1/CHUK/EXOC2/KDR/PLA2G2A/EGFR/GNGT2/CALML4/PAK4	1.21750790497722
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	20/1689	86/9376	1.29097993859033	ITGA1/SGCE/ITGA3/PKP2/ITGA6/SGCZ/ITGB5/CACNA2D3/CDH2/GJA1/DES/DMD/SGCB/DAG1/RYR2/TCF7L2/LEF1/SGCG/CACNB4/JUP	1.27065145752369
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	49/1689	233/9376	1.16742263116302	FBN2/NID2/ITGA1/SGCE/DAAM1/COL24A1/COL4A6/ITGA3/PKP2/TLN2/FMNL2/COL4A5/ITGA6/NEBL/SGCZ/SUN2/NEB/ITGB5/MYH10/FHL2/SDC1/ANK3/DAAM2/THBS4/COL27A1/DCN/CAPZA1/AMPD3/COL4A4/NID1/DES/ATP1B3/CAPN3/SDC2/CSRP1/DMD/SGCB/FMNL3/COL4A3/INF2/DAG1/PDLIM5/TPM1/SPTBN4/ACTG2/SGCG/JUP/SYNE3/COL5A1	1.21302509596285
Organismal Systems	Immune system	hsa04611	Platelet activation	28/1689	126/9376	1.23360305243076	RASGRP2/TLN2/MAPK14/MYLK3/FCER1G/LCP2/F2R/ROCK2/ADCY9/VAMP8/RAP1A/PPP1CB/RAP1B/PIK3CB/GNA13/MYLK/PTGIR/TBXAS1/SNAP23/PLCB1/PIK3CD/ADCY7/ADCY2/PIK3R6/MYL12A/PIK3CG/ITPR1/LYN	1.23741376250796
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	24/1689	106/9376	1.25687858172191	MMP9/PDGFRA/PDGFD/IL1R2/FOXO1/KLK3/IKBKB/INSRR/EP300/PDGFC/PIK3CB/FOLR2/MTOR/PIK3CD/PTEN/CREB3L1/CHUK/TCF7L2/SLC46A1/LEF1/EGFR/FOLR1/CASP9/SPINT1	1.24670293744064
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/1689	82/9376	1.28625684125403	KLRD1/KLRC1/HLA-DRB1/CD74/KLRC2/KLRC3/HLA-DMA/CTSB/B2M/HSPA2/KIR2DL4/HSPA1B/HLA-E/KIR2DL1/NFYA/KLRC4/HSPA1A/HLA-DMB/RFXAP	1.22034742541695
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	27/1689	122/9376	1.22854730221588	WNT4/ESR1/FOXO1/TBC1D4/PLCE1/KAT2B/NCOR1/MED14/NCOA1/RHEB/PLCD1/EP300/PLCD3/PIK3CB/SLC16A10/PLCB1/MTOR/PIK3CD/MED12L/FXYD2/ATP1B3/PLCD4/HIF1A/RCAN2/PLN/BMP4/CASP9	1.1910041902103
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	29/1689	133/9376	1.21041502512943	TGFBR1/DEPP1/HOMER2/MAPK14/SGK1/FOXO1/KLF2/HOMER1/INSR/CSNK1E/PRKAG1/IKBKB/EP300/PIK3CB/SETD7/NLK/PLK3/PIK3CD/STK4/GABARAPL2/PTEN/IRS2/RBL2/IRS1/CHUK/TNFSF10/PRKAA2/G6PC3/EGFR	1.14556072257067
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	29/1689	133/9376	1.21041502512943	MAOB/MAOA/MAPK14/GNB5/GNGT1/PPP1CB/CALM2/PPP2R3C/CLOCK/COMT/PPP2R1B/CAMK2G/PPP3CB/GNG2/PLCB1/GNG7/PPP3CC/ATF6B/CREB3L1/PPP2R2B/SLC18A2/PPP2R3A/ARRB2/GRIA4/ITPR1/KIF5C/GNGT2/CALML4/TH	1.14556072257067
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	23/1689	103/9376	1.23959141676295	COL24A1/COL4A6/SLC1A1/COL14A1/COL4A5/COL26A1/SLC7A8/CPA1/CPB1/MME/KCNE3/SLC38A2/SLC16A10/PRCP/COL27A1/COL13A1/COL4A4/FXYD2/ATP1B3/COL4A3/COL23A1/COL5A1/SLC7A7	1.14604523694538
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	20/1689	88/9376	1.26163948544055	CFH/SERPING1/F3/CLU/SERPINE1/VTN/SERPINB2/PLAUR/C3/F2R/CD46/TFPI/MASP1/C1QB/F12/PROS1/SERPINA5/CD59/F2RL2/C7	1.15586081660208
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	22/1689	98/9376	1.24619083868005	ATP2B4/SCARB1/ADCY9/PRKD1/CACNA1G/DAGLB/CALM2/CAMK2G/ATP2B3/DAGLA/LDLR/PLCB1/ADCY7/ADCY2/KCNK3/NPR1/ATP1B3/PRKCE/ATF6B/CREB3L1/ITPR1/CALML4	1.14836451470569
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1689	30/9376	1.48032366291691	GPLD1/PIGC/PIGL/PIGP/PIGU/PIGX/PIGB/PIGS	1.23510461349554
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	31/1689	144/9376	1.1950529570423	WNT4/WNT6/WNT5A/MAPK14/MEIS1/ID3/SMAD9/JARID2/ID1/WNT9A/SMAD2/WNT3/SKIL/APC/SMARCAD1/PIK3CB/KAT6A/WNT9B/PCGF6/ACVR2A/PIK3CD/WNT5B/TBX3/ACVR1C/WNT10B/LIFR/LEFTY2/ACVR1B/BMP4/JAK2/WNT1	1.105625150275
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1689	21/9376	1.58606106741098	CHSY1/CHST3/CSGALNACT2/CHST7/CHST13/CHPF	1.26023821727199
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1689	21/9376	1.58606106741098	ENPP1/ENPP3/DPYD/CSAD/ALDH3A2/BCAT2	1.26023821727199
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/1689	59/9376	1.3172371576803	PLIN1/ADCY9/INSR/PNPLA2/PIK3CB/ABHD5/PIK3CD/ADCY7/ADCY2/NPR1/IRS2/IRS1/PTGER3/FABP4	1.14576098737937
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	26/1689	119/9376	1.21287022802016	MMP9/MAP3K5/MAPK14/DAB2IP/CCL2/CCL5/ITCH/IKBKB/IL15/MMP14/TNFRSF1B/BAG4/PIK3CB/XIAP/TAB2/PIK3CD/CSF1/IL18R1/BIRC3/FAS/ATF6B/TRAF1/CREB3L1/CHUK/MAP2K7/SELE	1.095406457113
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	51/1689	248/9376	1.14158024408411	ABI1/PTPRC/MAPK14/KPNA1/ROCK2/ARHGEF26/VPS41/DCTN4/RHOH/KLC1/PODXL/PIK3C2A/ARPC1B/IKBKB/TUBA3E/DYNC2H1/SNX18/RHOB/TUBA4A/PIK3CB/IL18/IRAK4/VPS16/DCTN6/DYNLT3/PIK3C3/DNM2/TAB2/PIK3CD/KPNA3/DYNLRB1/CYTH3/SKP1/BIRC3/CYFIP2/TRAF6/MYL12A/VPS39/CHUK/EXOC2/MAP2K7/TNFSF10/PIK3CG/VPS11/TCF7L2/CSE1L/KIF5C/LEF1/WASF3/TIRAP/TNFRSF10A	1.05916276302041
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	28/1689	130/9376	1.19564603543289	TGFBR1/MMP9/COL4A6/RXFP1/COL4A5/MAPK14/EDNRB/ADCY9/SMAD2/GNB5/GNGT1/VEGFA/PIK3CB/GNG2/PLCB1/ACTA2/PIK3CD/GNG7/ADCY7/ADCY2/COL4A4/COL4A3/ATF6B/CREB3L1/MAP2K7/ARRB2/EGFR/GNGT2	1.05290164897177
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	12/1689	50/9376	1.33229129662522	KLRB1/KLRK1/CCL2/CD81/SDC1/ACKR1/IL18/THBS4/SDC2/CD36/HBB/SELE	1.10427765783586
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1689	17/9376	1.63270992233483	PCDH20/MYH10/TFRC/DAG1/PCDH7	1.22387314335947
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	20/1689	90/9376	1.23360305243076	MAPK14/CD247/IKBKB/PIK3CB/PPP3CB/MTOR/ZAP70/PIK3CD/CSNK2A1/IFNGR1/PTEN/PPP3CC/HIF1A/PTPN6/TRAF6/CHUK/NFKBIE/JAK2/EGFR/TIRAP	1.04377634629424
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1689	31/9376	1.43257128669379	H6PD/PGD/RBKS/DERA/ALDOC/RGN/SHPK/FBP1	1.13076121777837
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	8/1689	31/9376	1.43257128669379	SMOX/HIBCH/DPYD/CSAD/ALDH3A2/ALDH7A1/ACOX3/MLYCD	1.13076121777837
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	33/1689	157/9376	1.16681562602527	TGFBR1/SERPINE1/IGFBP3/MAPK14/FOXO1/SMAD2/HIPK2/MRAS/PPP1CB/CALM2/KIR2DL4/RHEB/RBBP4/FBXW11/SLC25A4/NBN/PIK3CB/LIN52/PPP3CB/HLA-E/MCU/MTOR/PIK3CD/BTRC/PTEN/PPP3CC/CCND3/RBL2/TRPM7/TSC1/SQSTM1/ITPR1/CALML4	0.988022126921885
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	9/1689	36/9376	1.38780343398461	ENPP1/ENPP3/PYGL/GAA/AGL/PGM2L1/G6PC3/PYGM/GYS1	1.09272652451969
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	22/1689	101/9376	1.20917526921431	WNT4/WNT6/WNT5A/WNT9A/EDNRB/ADCY9/WNT3/CALM2/EP300/CAMK2G/WNT9B/PLCB1/WNT5B/ADCY7/ADCY2/WNT10B/MITF/CREB3L1/TCF7L2/LEF1/CALML4/WNT1	0.990686139275076
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/1689	101/9376	1.20917526921431	TGFBR1/COL4A6/F3/SERPINE1/COL4A5/MAPK14/FOXO1/PLCE1/SMAD2/CCL2/VEGFA/PLCD1/PLCD3/PIK3CB/PLCB1/PIK3CD/COL4A4/PLCD4/PRKCE/COL4A3/JAK2/SELE	0.990686139275076
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	29/1689	137/9376	1.17507444045412	CTSD/MAP3K5/GZMB/PTPN13/CTSW/PARP4/NTRK1/PRF1/DAB2IP/CTSB/CTSZ/IKBKB/TUBA3E/CTSO/TUBA4A/PIK3CB/XIAP/PIK3CD/CSF2RB/BIRC3/FAS/BCL2L1/TRAF1/CHUK/TNFSF10/NOL3/ITPR1/CASP9/TNFRSF10A	0.967592669483035
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	23/1689	107/9376	1.19325155071574	FOXO1/SIK2/ACACB/CALM2/PRKAG1/PYGL/EP300/PPP4R3A/PHKA1/CAMK2G/PPP3CB/PLCB1/ADCY2/PHKB/PPP3CC/CREB3L1/PRKAA2/ITPR1/G6PC3/PYGM/FBP1/GYS1/CALML4	0.942367842451017
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	29/1689	138/9376	1.16655940827692	SORBS1/FOXO1/ACACB/CBL/PPP1CB/INSR/CALM2/PRKAG1/IKBKB/PYGL/RHEB/MKNK1/PRKAR2B/PIK3CB/PHKA1/PRKAR2A/MTOR/PIK3CD/PHKB/IRS2/IRS1/TSC1/PRKAA2/G6PC3/PYGM/FBP1/GYS1/CALML4/PPP1R3C	0.923935716634954
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	47/1689	232/9376	1.1245993344358	RGCC/ITGA1/ITGA3/PDGFRA/PDGFD/ITGAD/MYLK3/LPAR1/IQGAP2/F2R/ROCK2/VAV3/RAC2/ITGA6/TIAM1/MRAS/PIP5K1A/PPP1CB/EZR/ITGB5/MYH10/ARPC1B/APC/PIKFYVE/INSRR/PDGFC/PIK3CB/GNA13/ACTN1/MYLK/PIP5K1C/LIMK2/SSH1/ABI2/PIK3CD/WASF2/WASF1/BCAR1/CYFIP2/MYL12A/PTK2/EGFR/FGD3/C7/PIP4K2C/PAK4/CHRM5	0.900769408983381
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1689	32/9376	1.38780343398461	ACSS1/ACACB/HIBCH/MCEE/DBT/PCCB/ACOX3/MLYCD	1.03001191160729
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/1689	32/9376	1.38780343398461	ATG9B/ATG2B/ATG5/PIK3C3/MTOR/GABARAPL2/ATG4A/ATG4D	1.03001191160729
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	28/1689	134/9376	1.15995510900206	CALD1/PRKCH/KCNMA1/MYLK3/KCNMB4/ROCK2/ADCY9/PPP1CB/ADM/CALM2/MYH10/GNA13/MYLK/PTGIR/PLCB1/ACTA2/ADCY7/ADCY2/KCNMB2/NPR1/RAMP3/PRKCE/ARHGEF11/ITPR1/ACTG2/AVPR1A/PLA2G2A/CALML4	0.874157233529616
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	21/1689	98/9376	1.18954580055823	PLPP3/PLD1/MYO10/PTPRC/ASAP2/VAV3/RAC2/PIP5K1A/ARPC1B/PIK3CB/PIP5K1C/LIMK2/DNM2/PIK3CD/PLPP1/WASF2/WASF1/PRKCE/GAB2/LYN/WASF3	0.884142043788374
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/1689	23/9376	1.44814271372307	ARG1/GLUL/ASL/ASS1/GOT2/GLUD1	1.00861822895282
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1689	28/9376	1.38780343398461	PCBD1/PTS/FPGS/PCBD2/MOCS2/TH/MOCOS	0.963281759560155
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	10/1689	43/9376	1.29097993859033	APOA1/PLPP3/SCARB1/ACAT2/AGPAT2/PLPP1/CD36/GOT2/DGAT2/PLA2G2A	0.896414071375171
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	19/1689	89/9376	1.18509057284079	ITGA1/LAMA4/COL4A6/ITGA3/LAMC3/COL4A5/VTN/FREM1/ITGA6/ITGB5/SDC1/THBS4/COL4A4/CD36/COL4A3/DAG1/LAMB3/RELN/LAMA3	0.822363076401764
Cellular Processes	Cell motility	hsa04814	Motor proteins	39/1689	194/9376	1.11596564794638	KIF26B/MYO10/MYO1D/DNAH14/MYO1B/MYO5A/DNAH11/DCTN4/KLC1/MYH10/TUBE1/TUBA3E/DYNC2H1/TUBA4A/KIF21A/KIF13A/DCTN6/DYNLT3/ACTA2/CAPZA1/MYO9B/DYNLRB1/MYL12A/KIF27/DNAI1/TPM1/DNAH5/MYO18A/TUBG2/KIF7/KIF5C/ACTG2/KIF21B/DNALI1/MYO1G/KIFC3/KIF6/KIFC1/DNAH6	0.765039047594591
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	35/1689	173/9376	1.12307792345575	HLA-DRB1/KPNA1/HLA-DMA/MX1/CCL2/KPNA6/CCL5/ADAR/IFIH1/XPO1/IKBKB/IFNAR2/RSAD2/SLC25A4/EP300/OAS3/PIK3CB/EIF2AK2/IL18/IRAK4/STAT2/PIK3CD/IRF9/IFNGR1/IRF7/TMPRSS11D/CCND3/FAS/CHUK/TNFSF10/JAK2/HLA-DMB/CASP9/TNFRSF10A/KPNA5	0.765879637956642
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	21/1689	100/9376	1.16575488454707	ITGA1/ITGA3/HLA-DRB1/IL1R2/HLA-DMA/CD7/CSF3R/ITGA6/MME/CSF1R/IL7/TFRC/CD37/CD2/CD1D/CSF1/CD36/IL2RA/CD59/HLA-DMB/CSF2RA	0.781102427923772
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	19/1689	90/9376	1.17192289980922	FOXO1/ADCY9/SESN1/INSR/PRKAG1/ADIPOR1/RHEB/PIK3CB/ATG5/MTOR/PIK3CD/ADCY7/ADCY2/IRS2/ATF6B/CREB3L1/IRS1/TSC1/PRKAA2	0.768179415208494
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1689	44/9376	1.26163948544055	CCNH/MNAT1/TAF2/TAF4/GTF2E2/TAF3/GTF2H5/ERCC3/TAF6L/GTF2H2C	0.815387936713768
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	45/1689	227/9376	1.10046087276312	CCL3/PDGFRA/MAPK14/CCL4/AKAP13/ROCK2/ADCY9/RAC2/B2M/GNB5/CCL2/GNGT1/CCL5/CALM2/VEGFA/IKBKB/RHEB/IL10RB/PIK3CB/GNA13/PPP3CB/GNG2/HLA-E/PLCB1/MTOR/PIK3CD/GNG7/ADCY7/ADCY2/PPP3CC/BCAR1/ARHGEF11/FAS/ATF6B/CREB3L1/PTGER4/CHUK/TSC1/PTK2/PTGER3/ITPR1/EGFR/GNGT2/CALML4/CASP9	0.718199476223911
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1689	10/9376	1.66536412078153	PAPSS1/SUOX/SQOR	0.986743612870214
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1689	75/9376	1.18425893033353	CD82/SERPINE1/IGFBP3/AIFM2/SESN1/RCHY1/PTEN/CCND3/ZMAT3/FAS/BCL2L1/PERP/DDB2/COP1/CASP9/TNFRSF10A	0.750959261227723
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	15/1689	70/9376	1.18954580055823	ACACB/LEPR/PRKAG1/IKBKB/ADIPOR1/TNFRSF1B/MTOR/IRS2/CD36/IRS1/CHUK/PRKAA2/NFKBIE/G6PC3/JAK2	0.746111416471959
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	28/1689	138/9376	1.12633322178461	CPEB4/SPDYE2/MAPK14/RPS6KA2/ADCY9/SPDYA/PPP1CB/CALM2/FBXW11/ANAPC7/PPP2R1B/CAMK2G/PGR/PPP3CB/ANAPC10/ANAPC4/ADCY7/ADCY2/BTRC/CDC27/PPP3CC/SKP1/SPDYE5/CDC16/ITPR1/CPEB1/RPS6KA1/CALML4	0.700793650817393
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	28/1689	138/9376	1.12633322178461	WIPF1/MAPK14/RPS6KA2/LCP2/ROCK2/VAV3/RAC2/SKAP2/CCL2/PIP5K1A/FYB1/ARPC1B/IKBKB/PIK3CB/IL18/IRAK4/PIP5K1C/TAB2/ZAP70/PIK3CD/GIT2/WASF2/BCAR1/TRAF6/CHUK/MAP2K7/PTK2/RPS6KA1	0.700793650817393
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	14/1689	65/9376	1.19564603543289	SCARB1/KCNA4/ADCY9/CACNA1G/PDE8A/NCEH1/LDLR/PLCB1/ADCY7/ADCY2/KCNK3/ATF6B/CREB3L1/ITPR1	0.741910622481301
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	36/1689	181/9376	1.10410880935792	CTSD/CAMP/HLA-DRB1/CD74/MAPK14/FCER1G/CORO1A/PLA2R1/HLA-DMA/C3/ATP6V1H/MRC2/CALM2/IL10RB/EP300/ATP6V0B/IL18/CAMK2G/IRAK4/ATP6AP1/PPP3CB/PLK3/PIK3C3/IFNGR1/CLEC7A/PPP3CC/ATP6V0C/NFYA/TRAF6/ATP6V0D2/JAK2/HLA-DMB/RFXAP/CALML4/CASP9/TIRAP	0.662938013798337
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	10/1689	45/9376	1.23360305243076	ABCC1/ABCC3/ABCB7/ABCB8/ABCA8/ABCA3/ABCD3/ABCC9/ABCA5/ABCA7	0.736279481683708
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/1689	45/9376	1.23360305243076	KLRD1/KLRC1/GZMB/HLA-DRB1/HLA-DMA/PRF1/HLA-E/KIR2DL1/FAS/HLA-DMB	0.736279481683708
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1689	20/9376	1.38780343398461	UGDH/CYB5R1/CYB5R3/NPL/TGDS	0.813773539166234
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	16/1689	76/9376	1.16867657598704	APOA1/SORBS1/PLIN1/APOC3/FABP5/SLC27A6/ACADM/ANGPTL4/CYP27A1/GK/CD36/SCD5/ACOX3/LPL/FABP4/SLC27A2	0.692057406485582
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	31/1689	155/9376	1.11024274718769	HLA-DRB1/SCARB1/CORO1A/PLA2R1/HLA-DMA/C3/ATP6V1H/MRC2/ITGB5/TUBA3E/DYNC2H1/TFRC/PIKFYVE/ATP6V1A/TUBA4A/STX12/ATP6V0B/STX7/ATP6AP1/HLA-E/ATP6V0E1/THBS4/PIK3C3/CLEC7A/CD36/ATP6V0C/ATP6V1B2/ATP6V0D2/CYBA/HLA-DMB/SEC61A2	0.648707453045978
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/1689	97/9376	1.14458015173988	NOS1AP/PER3/ADCY9/GNB5/GNGT1/CACNA1G/CALM2/PER1/CAMK2G/GNG2/PLCB1/GNG7/ADCY7/ADCY2/GRIN2D/RYR2/GRIA4/ITPR1/GNGT2/CALML4	0.670912646750872
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	37/1689	187/9376	1.09836849320707	CAMP/ERBIN/MAPK14/CTSB/CCL2/CCL5/IKBKB/IFNAR2/ANTXR1/OAS3/IL18/ANTXR2/IRAK4/STAT2/TANK/ATG5/GPSM3/XIAP/MCU/PLCB1/TAB2/CARD8/GABARAPL2/DHX33/IRF9/MFN2/IRF7/PSTPIP1/TP53BP1/TRPM7/BIRC3/TRAF6/BCL2L1/CHUK/CYBA/RNF31/ITPR1	0.636890423802321
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	58/1689	300/9376	1.07323465561476	TGFBR1/RASGRP2/MAP3K5/PDGFRA/PDGFD/MAPK14/RPS6KA2/NTRK1/MAP3K2/MAP4K3/ERBB3/RAC2/RAP1A/MAPK7/AREG/RASA2/STMN1/MAP3K4/EPHA2/CACNA1G/MRAS/INSR/VEGFA/CACNA2D3/CSF1R/RAP1B/IKBKB/MAP3K13/MKNK1/MAP3K20/RASA1/PDGFC/IRAK4/TAOK1/IGF2/HSPA1B/NLK/ANGPT1/PPP3CB/TAB2/TEK/CDC25B/STK4/RET/CSF1/PPP3CC/TRAF6/MAPKAPK3/FAS/CHUK/PPP5C/MAP2K7/KDR/HSPA1A/ARRB2/EGFR/RPS6KA1/CACNB4	0.604299242480609
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	21/1689	103/9376	1.13180085878356	TGFBR1/CCL3/SERPINE1/MAPK14/CD247/C3/SMAD2/C1QB/CCL2/CCL5/IKBKB/PIK3CB/PPP2R1B/IRAK4/PLCB1/PIK3CD/IFNGR1/TRAF6/FAS/PPP2R2B/CHUK	0.630447235860956
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	31/1689	156/9376	1.10312580650058	SCARB1/CLDN4/CLDN20/MX1/PIAS1/CD81/IKBKB/IFNAR2/RSAD2/OAS3/PIK3CB/EIF2AK2/PPP2R1B/STAT2/CLDN10/LDLR/PIK3CD/CLDN3/IRF9/IFIT1/IRF7/OCLN/CLDN5/CLDN12/TRAF6/FAS/PPP2R2B/CHUK/CLDN23/EGFR/CASP9	0.608816226676251
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/1689	51/9376	1.19732060971221	ADCY9/ATP6V1H/ATP6V1A/ATP6V0B/TJP1/ATP6AP1/ATP6V0E1/ATP6V0C/ATP6V1B2/ATP6V0D2/SEC61A2	0.662300585533876
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	16/1689	77/9376	1.15349895811708	TGFBR1/PLD1/SMAD2/RAC2/POLK/VEGFA/IKBKB/PIK3CB/MTOR/PIK3CD/RALBP1/BCL2L1/CHUK/DDB2/EGFR/CASP9	0.633949543147732
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	22/1689	109/9376	1.12042846046464	TGFBR1/HLA-DRB1/MAPK14/CD247/HLA-DMA/IL2RB/SMAD2/RUNX1/IKBKB/GATA3/PPP3CB/MTOR/ZAP70/IFNGR1/PPP3CC/HIF1A/IL2RA/CHUK/NFKBIE/JAK2/HLA-DMB/IL21R	0.592781749762389
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	14/1689	67/9376	1.15995510900206	RPS6KA2/RAP1A/PPP1CB/CALM2/RAP1B/EP300/CAMK2G/PPP3CB/PLCB1/PPP3CC/GRIN2D/ITPR1/RPS6KA1/CALML4	0.615894073052094
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	21/1689	104/9376	1.12091815821834	PLPP3/PLD1/LCLAT1/CHPT1/PISD/LPIN1/SAMD8/LPCAT2/DGKB/PLPP5/CEPT1/LYPLA1/AGPAT2/PLPP1/PGS1/DGKH/MBOAT2/MBOAT7/PLA2G2A/GPAM/GPD1L	0.581223953432376
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	24/1689	120/9376	1.11024274718769	MAP3K5/MAPK14/RPS6KA2/NTRK1/ARHGDIB/RAP1A/MAPK7/MATK/CALM2/RAP1B/IKBKB/PIK3CB/CAMK2G/IRAK4/MAGED1/PIK3CD/TRAF6/IRS1/MAP2K7/SORT1/NFKBIE/RPS6KA1/PSEN2/CALML4	0.569706270513819
Human Diseases	Infectious disease: viral	hsa05162	Measles	27/1689	136/9376	1.10207919757601	IL2RB/CD46/MX1/ADAR/IFIH1/IKBKB/RCHY1/IFNAR2/OAS3/PIK3CB/EIF2AK2/IRAK4/STAT2/HSPA1B/TAB2/PIK3CD/CSNK2A1/IRF9/IRF7/CCND3/IL2RA/TRAF6/FAS/BCL2L1/CHUK/HSPA1A/CASP9	0.56207301901554
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	17/1689	83/9376	1.13699558446932	PEX11A/NUDT12/PEX3/HACL1/ABCD3/PEX11B/PEX7/PEX6/SLC25A17/FAR1/PEX14/NUDT19/ACOX3/CROT/MLYCD/SLC27A2/DECR2	0.587610665110995
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	49/1689	254/9376	1.07090343724796	ATP2B4/PDGFRA/PDGFD/MYLK3/PLCE1/ITPKC/NTRK1/F2R/EDNRB/ADCY9/ERBB3/HTR2B/CACNA1G/CALM2/VEGFA/PLCD1/SLC25A4/PDE1A/PDGFC/TACR1/PLCD3/PHKA1/CAMK2G/MYLK/ATP2B3/PPP3CB/MCU/PLCB1/ADCY7/RET/ADCY2/PHKB/PPP3CC/GRIN2D/PLCD4/TFEB/CYSLTR1/KDR/RYR2/PLN/HTR2A/PTGER3/ITPR1/AVPR1A/EGFR/OXTR/CALML4/PTGFR/CHRM5	0.536983741014562
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1689	16/9376	1.38780343398461	ST3GAL1/HEXB/HEXA/ST3GAL2	0.727705638233627
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	23/1689	115/9376	1.11024274718769	PLD1/SGK1/AKAP13/PDE4B/ADCY9/WNK3/MEF2A/MMP14/GATA3/OXSR1/GNA13/PLCB1/ADCY7/ADCY2/BGLAP/ARHGEF11/ATF6B/CREB3L1/ARRB2/ITPR1/LRP5/EGFR/WNK2	0.5575605368752
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	16/1689	78/9376	1.13871050993609	DHX36/PARN/NUDT16/TENT4B/CNOT2/PNPT1/EXOSC8/PAN3/CNOT9/MTREX/DCP1B/CNOT10/DIS3L/CNOT6/EXOSC9/EDC3	0.576612325076185
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	28/1689	142/9376	1.09460552539631	TGFBR1/TYROBP/MAPK14/FOSL2/LCP2/LILRB3/CSF1R/FHL2/IKBKB/IFNAR2/ACP5/PIK3CB/STAT2/PPP3CB/TAB2/PIK3CD/IRF9/IFNGR1/CSF1/PPP3CC/GAB2/TRAF6/MITF/CHUK/MAP2K7/CYBA/SQSTM1/ITPR1	0.532460948509929
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/1689	89/9376	1.12271738479654	PDGFRA/PDGFD/LPAR1/MAP3K2/ADCY9/HTR2B/MAPK7/TUBA3E/GJA1/PDGFC/TUBA4A/TJP1/PLCB1/ADCY7/ADCY2/HTR2A/ITPR1/EGFR	0.545237094144533
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	38/1689	196/9376	1.07625572431459	MAPK14/C3/GNB5/GNGT1/CALM2/VEGFA/IKBKB/IFNAR2/EP300/PIK3CB/EIF2AK2/STAT2/PPP3CB/GNG2/HLA-E/PIK3C3/MTOR/PIK3CD/GNG7/PIK3R6/IRF9/IFNGR1/IRF7/PPP3CC/HIF1A/ATG14/FAS/CHUK/MAP2K7/PIK3CG/TCF7L2/ITPR1/LYN/JAK2/LEF1/GNGT2/CALML4/CASP9	0.505709565162538
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1689	42/9376	1.18954580055823	MAOB/MAOA/DHTKD1/ACAT2/KYNU/KYAT1/ALDH3A2/ALDH7A1/INMT	0.577067925810969
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	8/1689	37/9376	1.20026242939209	ALDH5A1/RIMKLB/GLUL/ASL/GFPT1/ASS1/GOT2/GLUD1	0.572100302090275
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1689	37/9376	1.20026242939209	CCDC6/NTRK1/TFG/POLK/RET/TCF7L2/DDB2/LEF1	0.572100302090275
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	33/1689	170/9376	1.07758854874099	TGFBR1/WNT4/WNT6/WNT5A/MGST2/SMARCB1/WNT9A/SMAD2/WNT3/POLK/APC/DPF3/BRD7/PBRM1/PIK3CB/WNT9B/MGST1/IGF2/GSTA1/MTOR/PIK3CD/TXNRD2/WNT5B/PTEN/WNT10B/TXNRD3/BCL2L1/TCF7L2/DDB2/LRP5/LEF1/EGFR/WNT1	0.478529401436828
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	43/1689	224/9376	1.06563477966675	TGFBR1/TLN2/HLA-DRB1/IL1R2/ETS2/HLA-DMA/IL2RB/ADCY9/SMAD2/KAT2B/B2M/DLG1/CRTC1/CDKN2C/XPO1/IKBKB/IL15/ANAPC7/SLC25A4/EP300/PIK3CB/LTBR/PPP3CB/HLA-E/ANAPC10/XIAP/ANAPC4/PIK3CD/ADCY7/ADCY2/CDC27/PTEN/PPP3CC/CCND3/IL2RA/ATF6B/BCL2L1/CREB3L1/CHUK/TSPO/POLB/CDC16/HLA-DMB	0.466038780942025
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	45/1689	235/9376	1.06299837496693	CNR1/MAP3K5/PLIN1/MAPK14/RPS6KA2/SMARCB1/ADCY9/ZNF516/PRKAG1/RHEB/COX17/DPF3/NDUFS4/PNPLA2/SDHC/NDUFS8/COA1/COX20/NDUFA4/MTOR/KDM3B/UQCR10/NDUFA7/ADCY7/ADCY2/NDUFC2/NDUFB3/NPR1/MT-CO2/NDUFAF6/BMP8A/NDUFAF8/ATP5MG/CREB3L1/COX7B/NDUFA13/TSC1/UQCR11/PRKAA2/SLC25A29/NDUFS2/SIRT6/RPS6KA1/NDUFAF5/COX18	0.458446272716289
NA	NA	hsa04519	Cadherin signaling	76/1689	404/9376	1.04428773250327	KRT23/WNT4/WNT6/DAAM1/WNT5A/MPDZ/LIMA1/PKP2/PDGFRA/ERBIN/MAPK14/PCDH20/MYO1D/CDH11/CTNND1/TEAD1/ROCK2/WNT9A/MYO1B/VAV3/RAC2/WNT3/ADAM10/KRT81/MRAS/PPP1CB/AFDN/ARPC1B/IKBKB/PCDHB16/APC/CDH20/CDH2/KRT18/GJA1/PCDH19/RERE/APH1B/EP300/KRT86/DAAM2/ACTN1/TJP1/WNT9B/TAOK1/MOB1B/ABI2/NCSTN/WNT5B/CELSR1/DES/WASF1/ATN1/LATS1/WNT10B/TMIE/CYFIP2/CHUK/PCDH7/KDR/TCF7L2/DSG3/PTK2/CDH23/LRP5/LEF1/WWC1/EGFR/LHFPL6/MYO1G/PSEN2/JUP/DCHS2/WNT1/CDH26/FAT1	0.426531900585462
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/1689	69/9376	1.12633322178461	REN/KCNMA1/CTSB/CALM2/PDE3A/PDE1A/PPP3CB/PLCB1/NPR1/PPP3CC/PTGER4/AQP1/ITPR1/CALML4	0.493695629555934
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	14/1689	69/9376	1.12633322178461	MAOB/MAOA/PPP1CB/CALM2/CAMK2G/PPP3CB/PPP3CC/GRIN2D/ATF6B/CREB3L1/SLC18A2/GRIA4/CALML4/TH	0.493695629555934
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	73/1689	388/9376	1.04442938846264	WNT4/WNT6/WNT5A/MAP3K5/WNT9A/WNT3/ADAM10/MME/KLC1/SLC39A10/INSR/CALM2/CSNK1E/IKBKB/TUBA3E/ATG2B/APC/SLC39A11/SLC25A4/APH1B/TUBA4A/NDUFS4/PIK3CB/SLC39A6/EIF2AK2/SDHC/NDUFS8/WNT9B/IDE/PPP3CB/NDUFA4/DKK1/MCU/PIK3C3/PLCB1/MTOR/PIK3CD/NCSTN/WNT5B/UQCR10/NDUFA7/CSNK2A1/BACE1/NDUFC2/NDUFB3/CSF1/PPP3CC/GRIN2D/IRS2/SLC39A2/MT-CO2/WNT10B/PSMD3/SLC39A4/ATG14/FAS/COX7B/IRS1/CHUK/NDUFA13/PSMD1/MAP2K7/UQCR11/ITPR1/NDUFS2/LPL/KIF5C/LRP5/PSEN2/CALML4/CASP9/WNT1/CHRM5	0.418963982286368
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1689	38/9376	1.16867657598704	UGDH/GFPT1/HEXB/UXS1/PMM2/HEXA/GALE/AMDHD2	0.48836177384913
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1689	70/9376	1.11024274718769	SGCE/HLA-DRB1/HLA-DMA/PRF1/RAC2/SGCZ/EIF4G3/HLA-E/DMD/SGCB/DAG1/HLA-DMB/SGCG/CASP9	0.433949852846743
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	18/1689	93/9376	1.07442846502034	MAML3/STAT4/HLA-DRB1/MAPK14/CD247/HLA-DMA/IL2RB/IKBKB/GATA3/PPP3CB/ZAP70/IFNGR1/PPP3CC/IL2RA/CHUK/NFKBIE/JAK2/HLA-DMB	0.338110286625619
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1689	18/9376	1.23360305243076	AGA/HEXB/HEXA/GBA2	0.464991771701335
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/1689	110/9376	1.05977716777006	SERPINE1/EPAS1/EGLN3/INSR/VEGFA/TFRC/MKNK1/EP300/PIK3CB/CAMK2G/LTBR/ANGPT1/MTOR/TEK/PIK3CD/IFNGR1/ARNT/ALDOC/HIF1A/CUL2/EGFR	0.2956021248295
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	14/1689	72/9376	1.07940267087692	ISG15/MAPK14/RNF125/ADAR/IFIH1/IKBKB/PIN1/TANK/ATG5/IRF7/TRAF6/CHUK/DHX58/DDX3X	0.317021364496111
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	16/1689	83/9376	1.07011349126524	CCL4/POLR2K/CCL5/ADAR/POLR3GL/IKBKB/SAMHD1/IL18/POLR3B/IRF7/POLR3A/CHUK/POLR3E/ZDHHC1/ZBP1/POLR3C	0.300735497390053
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1689	29/9376	1.14852697984933	TEAD1/CSNK1E/MOB1B/LATS1/WWC1/DCHS2	0.375482975055981
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	20/1689	105/9376	1.05737404494065	CCL4/CCL21/IKBKB/ERC1/LTBR/IRAK4/TNFSF13B/XIAP/TAB2/ZAP70/CSNK2A1/BIRC3/TRAF6/BCL2L1/TRAF1/CHUK/TNFSF14/LYN/CCL13/TIRAP	0.277120625565145
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	23/1689	122/9376	1.04654029448019	PTPRC/MAPK14/NCK1/CD247/LCP2/ITK/VAV3/DLG1/IKBKB/PPP2R3C/PIK3CB/PPP2R1B/PPP3CB/ZAP70/PIK3CD/PPP3CC/PTPN6/PPP2R2B/CHUK/MAP2K7/PPP2R3A/NFKBIE/PAK4	0.242530474882508
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	27/1689	144/9376	1.04085257548845	MAP3K5/MAPK14/FOXO1/C3/ACACB/C1QB/PRKAG1/IKBKB/ADIPOR1/LPIN1/IRAK4/ACADM/TAB2/TRA2B/ALDH3A2/SCD5/TRAF6/FAS/CHUK/ALDH7A1/MAP2K7/TCF7L2/PRKAA2/ACOX3/LEF1/MLYCD/TIRAP	0.231566009551696
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/1689	62/9376	1.07442846502034	MAML3/LFNG/TLE2/KAT2B/TLE6/ITCH/APH1B/EP300/NCSTN/ATXN1/HEYL/PSEN2	0.275606091871415
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	15/1689	79/9376	1.05402792454527	SYT1/SLC1A1/SLC1A2/ATP6V1H/UNC13B/VAMP2/ATP6V1A/ATP6V0B/STXBP1/ATP6V0E1/DNM2/ATP6V0C/ATP6V1B2/SLC18A2/ATP6V0D2	0.226038510741377
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	37/1689	201/9376	1.02186521507324	MMP9/GZMB/IGFBP3/IL1R2/FOXO1/MEIS1/NTRK1/IL2RB/RUNX1/NR4A3/POLK/AFF1/NCOR1/CDKN2C/CSF1R/SS18/NSD2/CDK14/WT1/HOXA9/FLI1/CCNT2/SUPT3H/SLC45A3/SS18L1/KMT2A/BIRC3/MITF/BCL2L1/TRAF1/LDB1/DDB2/PTK2/MLLT3/SIX4/JUP/SPINT1	0.146882740964626
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1689	80/9376	1.04085257548845	PDGFRA/PDGFD/NRG2/ERBB3/VEGFA/PDGFC/PIK3CB/AXL/MTOR/PIK3CD/PTEN/BCL2L1/KDR/JAK2/EGFR	0.172003941751601
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1689	47/9376	1.06299837496693	CACNA1G/INSR/IKBKB/PIK3CB/MTOR/PIK3CD/IRS2/PRKCE/IRS1	0.20294705422678
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	67/1689	368/9376	1.01068293561922	MAP3K5/MAPK14/DNAH14/GPX3/NRG2/RANBP2/SLC1A2/DNAH11/DCTN4/ANG/KLC1/NUP160/DERL1/FIG4/RAB1A/TUBA3E/ATG2B/TNFRSF1B/TUBA4A/NDUFS4/SDHC/NDUFS8/TANK/POM121/ALS2/DCTN6/NUP210L/PPP3CB/NDUFA4/MCU/PIK3C3/ATXN2/MTOR/ANXA11/UQCR10/GPX8/NDUFA7/NDUFC2/NDUFB3/PPP3CC/GRIN2D/PRKN/NUP210/NUP214/MT-CO2/PSMD3/ATG14/BCL2L1/COX7B/NDUFA13/DNAI1/PSMD1/NUP133/UQCR11/NUP155/NUP93/DNAH5/NDC1/ALYREF/SQSTM1/NDUFS2/NUP85/KIF5C/DNALI1/CASP9/DNAH6/NUP35	0.0979991602267681
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	16/1689	86/9376	1.03278395087227	KCNMA1/KCNMB4/ADCY9/VAMP2/CAMK2G/PLCB1/ADCY7/ADCY2/RIMS2/KCNMB2/FXYD2/ATP1B3/ATF6B/CREB3L1/RYR2/TRPM4	0.143160986152648
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	14/1689	75/9376	1.03622656404184	MAP3K5/MGST2/REV3L/PIK3CB/MGST1/XIAP/GSTA1/PIK3CD/BIRC3/FAS/BCL2L1/POLH/ATP7B/CASP9	0.147643719196865
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1689	31/9376	1.07442846502034	SEC11C/SRP19/IMMP1L/TMEM208/SEC61A2/SPCS3	0.19455942715715
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	39/1689	214/9376	1.01166979299812	BST2/MAPK14/CD247/RAC2/B2M/GNB5/GNGT1/CALM2/IKBKB/SAMHD1/TNFRSF1B/FBXW11/PIK3CB/IRAK4/LIMK2/PPP3CB/GNG2/HLA-E/MTOR/TAB2/PIK3CD/GNG7/BTRC/PPP3CC/SKP1/CUL4A/TRAF6/FAS/BCL2L1/CHUK/APOBEC3G/MAP2K7/AP1B1/PTK2/ITPR1/GNGT2/CALML4/CASP9/PAK4	0.0809462842782123
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/1689	70/9376	1.03093969381714	EPAS1/RAP1A/EGLN3/VEGFA/RAP1B/EP300/PIK3CB/PIK3CD/ARNT/HIF1A/CUL2/FLCN/PAK4	0.121788289221527
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1689	37/9376	1.05022962571808	APOA1/LAMA4/IL18/PLCB1/FAS/HBB/SELE	0.143493635498312
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1689	26/9376	1.06754110306508	APOA1/SCARB1/ABCC1/BTD/SLC46A1	0.16164826222291
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/1689	93/9376	1.01473799474143	ATP2B4/CAMP/KCNMA1/BST1/ADCY9/CALM2/VAMP2/SLC4A2/ATP2B3/PLCB1/ADCY7/ADCY2/FXYD2/ATP1B3/ITPR1/CST2/CALML4	0.0669511002940982
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	20/1689	110/9376	1.00931158835244	CPEB4/SPDYE2/MAPK14/RPS6KA2/ADCY9/SPDYA/ANAPC7/PIK3CB/PGR/ANAPC10/CDC25B/ANAPC4/PIK3CD/ADCY7/ADCY2/CDC27/SPDYE5/CDC16/CPEB1/RPS6KA1	0.0460464321947626
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	37/1689	205/9376	1.0019263816084	TGFBR1/MMP9/REN/CTSD/MAPK14/TBC1D4/SMAD2/RAC2/PPP1CB/INSR/SLC25A4/NDUFS4/PIK3CB/GFPT1/SDHC/CAMK2G/NDUFS8/NDUFA4/PLCB1/MTOR/PIK3CD/UQCR10/NDUFA7/NDUFC2/NDUFB3/PTEN/CD36/MT-CO2/COX7B/IRS1/NDUFA13/UQCR11/RYR2/PLN/CYBA/NDUFS2/GYS1	0.0130717258081624
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	18/1689	99/9376	1.00931158835244	PRKCH/MAPK14/NTRK1/ADCY9/HTR2B/PPP1CB/CALM2/PIK3CB/CAMK2G/PLCB1/PIK3CD/ADCY7/ADCY2/PRKCE/PTGER4/HTR2A/ITPR1/CALML4	0.0436575751097892
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1689	15/9376	1.11024274718769	AK1/TPK1/AK5	0.200288750137825
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1689	60/9376	1.01772251825538	MAPK14/RAC2/VEGFA/PIK3CB/PPP3CB/PIK3CD/PPP3CC/MAPKAPK3/KDR/PTK2/CASP9	0.0645517975023561
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	19/1689	105/9376	1.00450534269362	ITGA1/SGCE/ITGA3/ADCY9/ITGA6/SGCZ/ITGB5/CACNA2D3/ADCY7/ADCY2/DES/DMD/SGCB/DAG1/TPM1/RYR2/PLN/SGCG/CACNB4	0.0217611184104719
NA	NA	hsa04382	Cornified envelope formation	39/1689	217/9376	0.997683574661745	KRT23/COL4A6/PKP2/COL4A5/KAZN/S100A1/CLDN4/CLDN20/ITGA6/KRT81/SPTLC2/SPTLC1/PPP2R3C/KRT18/KRT86/PPP2R1B/TJP1/ABHD5/CLDN10/CLDN3/COL4A4/ELOVL1/OCLN/CLDN5/CLDN12/COL4A3/TGM1/PPP2R2B/CDSN/LAMB3/PPP2R3A/DSG3/TCHH/CLDN23/GBA2/DST/JUP/ELOVL4/LAMA3	-0.016182520531156
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1689	38/9376	1.02259200398866	SGK1/INSR/PIK3CB/PIK3CD/FXYD2/ATP1B3/IRS1	0.0654096223980454
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1689	61/9376	1.00103854254627	ATP2B4/SLC40A1/ATP2B3/HMOX2/FXYD2/ATP1B3/TRPM7/SLC39A4/SLC46A1/SLC26A6/ATP7B	0.00381434352338796
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1689	27/9376	1.0280025436923	ALDH5A1/ACAT2/OXCT1/ACSM6/BDH1	0.0682997019005844
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1689	39/9376	0.996371696194076	MTR/MTHFS/BHMT2/MTHFD2L/DMGDH/ALDH7A1/TYMS	-0.0106427605446532
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/1689	39/9376	0.996371696194076	GZMB/HLA-DRB1/HLA-DMA/PRF1/HLA-E/FAS/HLA-DMB	-0.0106427605446532
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1689	16/9376	1.04085257548845	MAOB/MAOA/GOT2	0.0766590672337714
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1689	22/9376	1.00931158835244	MAOB/MAOA/ALDH3A2/ALDH7A1	0.0204954967351843
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	18/1689	102/9376	0.979625953400899	ATP2B4/KCNMA1/BST1/CPA1/CPB1/ADCY9/RAP1A/RAP1B/SLC4A2/ATP2B3/PLCB1/ADCY7/ADCY2/FXYD2/ATP1B3/RYR2/ITPR1/PLA2G2A	-0.0969763552679714
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/1689	51/9376	0.979625953400899	PLPP3/PLD1/PLA2G7/CHPT1/LPCAT2/CEPT1/ENPP2/PLPP1/PLA2G2A	-0.0683848636589958
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1689	28/9376	0.991288167131862	ATP6V1A/ATP6V0E1/ATP6V0C/ATP6V1B2/ATP6V0D2	-0.0216396992878291
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1689	91/9376	0.976037579945218	GRK5/GRK3/PDE4B/ADCY9/GNB5/GNGT1/PDE8A/PDE3A/PDE1A/GNG2/GNG7/ADCY7/GRK4/ADCY2/ARRB2/GNGT2	-0.1076669576967
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	27/1689	154/9376	0.973264745911282	DHRS3/VKORC1L1/PTS/FPGS/CMPK1/UGDH/MOCS2/KYNU/ALAD/AK3/NMNAT3/AK9/MTHFD2L/AK6/AK1/PMM2/HSD17B6/RGN/ALDH3A2/BCAT2/NME7/TPK1/PPOX/CMPK2/PHOSPHO2/NADSYN1/AK5	-0.156802917821812
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	27/1689	154/9376	0.973264745911282	ATP2B4/MAPK14/ADCY9/PPP1CB/CALM2/CACNA2D3/PPP2R3C/PPP2R1B/CAMK2G/ATP2B3/PLCB1/CREM/ADCY7/ADCY2/PIK3R6/FXYD2/ATP1B3/ATF6B/CREB3L1/PPP2R2B/PIK3CG/TPM1/RYR2/PPP2R3A/PLN/CACNB4/CALML4	-0.156802917821812
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	27/1689	154/9376	0.973264745911282	MYLK3/ROCK2/ADCY9/MAPK7/PPP1CB/CALM2/CACNA2D3/PRKAG1/CAMK2G/MYLK/PPP3CB/PLCB1/ADCY7/ADCY2/PIK3R6/NPR1/PPP3CC/EEF2K/PIK3CG/RYR2/PRKAA2/ITPR1/RGS2/EGFR/CACNB4/OXTR/CALML4	-0.156802917821812
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/1689	69/9376	0.965428475815378	MAPK14/FCER1G/LCP2/VAV3/RAC2/MS4A2/PIK3CB/PIK3CD/ALOX5AP/GAB2/MAP2K7/LYN	-0.135101520850429
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	20/1689	115/9376	0.965428475815378	KCNQ5/ADCY9/GNB5/GNGT1/PIK3CB/CAMK2G/GNG2/PLCB1/PIK3CD/GNG7/ADCY7/ADCY2/PIK3R6/KCNQ3/CREB3L1/PIK3CG/ITPR1/JAK2/GNGT2/CHRM5	-0.174847943077428
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/1689	75/9376	0.962210380895994	ARG1/MTR/PC/GLUL/ASL/PYCR2/ENO4/ALDOC/BCAT2/ALDH18A1/ASS1/GOT2/SDSL	-0.154014051818564
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/1689	75/9376	0.962210380895994	GPX3/ADCY9/PLCB1/GPX8/ADCY7/ADCY2/FXYD2/ATP1B3/ATF6B/CREB3L1/ITPR1/TG/TTF1	-0.154014051818564
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	24/1689	138/9376	0.965428475815378	ATP6V1H/COX17/ATP6V1A/NDUFS4/ATP6V0B/SDHC/NDUFS8/ATP6AP1/NDUFA4/ATP6V0E1/UQCR10/NDUFA7/NDUFC2/NDUFB3/PPA2/MT-CO2/ATP6V0C/ATP5MG/COX7B/ATP6V1B2/NDUFA13/UQCR11/ATP6V0D2/NDUFS2	-0.191774612452848
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1689	17/9376	0.979625953400899	CYP39A1/CYP7B1/CYP27A1	-0.0394102377313421
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1689	17/9376	0.979625953400899	GLUL/CA12/GLUD1	-0.0394102377313421
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1689	23/9376	0.965428475815378	REN/MME/NLN/PRCP	-0.0778088506797427
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1689	23/9376	0.965428475815378	FXYD2/ATP1B3/AQP1/GLUD1	-0.0778088506797427
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/1689	93/9376	0.955047524462525	PLD1/MAPK14/MAP3K2/ADCY9/MAPK7/MAP3K4/CALM2/MMP14/CAMK2G/PLCB1/ADCY7/ADCY2/MAP2K7/ITPR1/EGFR/CALML4	-0.204208086037422
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	17/1689	99/9376	0.953238722332861	ITGA1/SGCE/ITGA3/ITGA6/SGCZ/ITGB5/CACNA2D3/PRKAG1/DES/DMD/SGCB/DAG1/TPM1/RYR2/PRKAA2/SGCG/CACNB4	-0.219241220156351
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1689	76/9376	0.949549717989468	MYLK3/ADCY9/EZR/CALM2/SLC4A2/CAMK2G/MYLK/PLCB1/ADCY7/ADCY2/ATP1B3/ITPR1/CALML4	-0.206990752096833
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	44/1689	253/9376	0.965428475815378	TLN2/MAPK14/FOXO1/PLCE1/C3/ROCK2/SEPTIN6/CCL5/FNBP1L/ARPC1B/IKBKB/PLCD1/FBXW11/SEPTIN9/PLCD3/PIK3CB/IL18/ACTN1/ATG5/PIK3C3/PLCB1/MTOR/TAB2/PIK3CD/WASF2/BTRC/GLMN/WASF1/PLCD4/CYTH3/BCAR1/PRKCE/SKP1/ATG14/TRAF6/MYL12A/BCL2L1/CHUK/RNF31/PTK2/SQSTM1/ITPR1/TIFA/EGFR	-0.261295525427764
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1689	47/9376	0.944887444415051	ACSS1/ACACB/HAGH/PC/ACAT2/DLAT/ALDH3A2/ALDH7A1	-0.177543163815669
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1689	59/9376	0.94088368405736	GGT5/PGD/MGST2/GPX3/LANCL1/MGST1/GSTA1/ODC1/GPX8/CHAC2	-0.213509568109698
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1689	59/9376	0.94088368405736	POLK/APC/PIK3CB/PIK3CD/PTEN/TCF7L2/DDB2/LEF1/EGFR/CASP9	-0.213509568109698
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	27/1689	157/9376	0.954667330384315	MAP3K5/MAPK14/INSR/LEPR/ITCH/PRKAG1/IKBKB/ADIPOR1/NDUFS4/PIK3CB/SDHC/NDUFS8/NDUFA4/PIK3CD/UQCR10/NDUFA7/NDUFC2/NDUFB3/IRS2/MT-CO2/FAS/COX7B/IRS1/NDUFA13/UQCR11/PRKAA2/NDUFS2	-0.268498112077042
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	39/1689	226/9376	0.957952812838932	ATP2B4/PLD1/PDE4B/VIPR2/PLCE1/F2R/ROCK2/ADCY9/VAV3/RAC2/RAP1A/TIAM1/PPP1CB/AFDN/CALM2/RAP1B/GLI3/PDE3A/EP300/PIK3CB/CAMK2G/ATP2B3/FXYD1/PIK3CD/ADCY7/ADCY2/FXYD2/NPR1/GRIN2D/ATP1B3/CREB3L1/RYR2/PLN/GRIA4/ACOX3/PTGER3/ARAP3/OXTR/CALML4	-0.299918077123837
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1689	18/9376	0.925202289323071	ACACB/CBR4/ACSF3	-0.148886410708087
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1689	12/9376	0.925202289323071	NCAM1/CD46	-0.121526292473174
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	35/1689	205/9376	0.947768198818756	ISG15/HLA-DRB1/MAPK14/CD247/HLA-DMA/B2M/POLK/ENTPD1/IKBKB/IFNAR2/ENTPD3/OAS3/PIK3CB/EIF2AK2/IRAK4/STAT2/HLA-E/TAB2/PIK3CD/IRF9/IRF7/CCND3/CD58/NEDD4/PSMD3/TRAF6/FAS/CHUK/PSMD1/MAP2K7/DDB2/NFKBIE/LYN/HLA-DMB/CASP9	-0.354426028846516
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/1689	78/9376	0.925202289323071	ARHGEF26/SEPTIN6/CBL/ARPC1B/SEPTIN9/PIK3CB/DNM2/PIK3CD/WASF2/WASF1/CAV2/BCAR1/PTK2	-0.310930165880526
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1689	43/9376	0.903685957013232	ACAT2/ACADM/ALDH3A2/ALDH7A1/ECI1/ACOX3/ACADSB	-0.296712082017192
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1689	37/9376	0.900196822044069	MAOB/MAOA/COMT/FAH/GOT2/TH	-0.285113031093651
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1689	37/9376	0.900196822044069	UGDH/GFPT1/UXS1/PMM2/GALE/TGDS	-0.285113031093651
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1689	49/9376	0.906320609949131	MAOB/MAOA/GPSM1/GRIN2D/ATF6B/CREB3L1/SLC18A2/TH	-0.308171965627001
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1689	31/9376	0.895357054183617	HSD17B14/UGDH/RGN/ALDH3A2/ALDH7A1	-0.273541468153458
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1689	31/9376	0.895357054183617	ACSS1/GLUL/ACAT2/MCEE/PCCB	-0.273541468153458
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	83/1689	480/9376	0.959897375172686	WNT4/WNT6/WNT5A/MAP3K5/MAPK14/DNAH14/GPX3/WNT9A/WNT3/DNAH11/DCTN4/KLC1/DERL1/HIP1/CALM2/FIG4/RAB1A/CSNK1E/TUBA3E/ATG2B/APC/TNFRSF1B/SLC25A4/TUBA4A/NDUFS4/SDHC/CAMK2G/NDUFS8/WNT9B/TANK/ALS2/DCTN6/HTT/PPP3CB/NDUFA4/DKK1/MCU/PIK3C3/PLCB1/ATXN2/MTOR/WNT5B/UQCR10/GPX8/NDUFA7/CSNK2A1/MFN2/NDUFC2/NDUFB3/CSF1/PPP3CC/GRIN2D/PRKN/MT-CO2/WNT10B/PSMD3/ATG14/FAS/BCL2L1/ATXN1/COX7B/NDUFA13/DNAI1/PSMD1/MAP2K7/UQCR11/RYR2/DNAH5/GRIA4/GPR37/SQSTM1/ITPR1/NDUFS2/KIF5C/LRP5/DNALI1/SNCAIP/PSEN2/CALML4/CASP9/WNT1/DNAH6/CHRM5	-0.422783522988602
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	15/1689	91/9376	0.915035231198641	VAV3/RAC2/CD81/LILRB3/IKBKB/CD79B/PIK3CB/PPP3CB/PIK3AP1/PIK3CD/PPP3CC/PTPN6/CHUK/NFKBIE/LYN	-0.381760195645181
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1689	19/9376	0.876507431990278	DHTKD1/DLAT/DBT	-0.252563931895419
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	17/1689	103/9376	0.916219742824789	MSI2/PPP1CB/PPP2R3C/UPF2/PELO/PPP2R1B/SMG7/UPF3B/CPSF6/CASC3/PAPOLG/CPSF2/HBS1L/PPP2R2B/PPP2R3A/ALYREF/SMG5	-0.400748766307882
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1689	103/9376	0.916219742824789	LAMA4/COL4A6/ARG1/LAMC3/COL4A5/IL1R2/PIK3CB/ACTN1/SERPINB9/PLCB1/PIK3CD/COL4A4/CD1D/COL4A3/LAMB3/PTK2/LAMA3	-0.400748766307882
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/1689	68/9376	0.897990457284157	RUNX1/CSF1R/IKBKB/PIK3CB/MTOR/PIK3CD/CHUK/TCF7L2/PIM2/LEF1/JUP	-0.395720994847834
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/1689	44/9376	0.883147639808386	GZMB/HLA-DRB1/HLA-DMA/PRF1/HLA-E/FAS/HLA-DMB	-0.364165235672822
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1689	44/9376	0.883147639808386	ARHGDIB/ADCY9/DCTN4/VAMP2/DYNC2H1/DCTN6/CREB3L1	-0.364165235672822
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1689	32/9376	0.867377146240379	XIAP/BIRC6/BIRC3/BCL2L1/CASP9	-0.352248348396998
Human Diseases	Immune disease	hsa05310	Asthma	5/1689	32/9376	0.867377146240379	HLA-DRB1/FCER1G/HLA-DMA/MS4A2/HLA-DMB	-0.352248348396998
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1689	13/9376	0.854032882452065	XRCC4/LIG4	-0.246854596827382
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/1689	116/9376	0.909250525714052	H6PD/PGD/ACSS1/PC/HIBCH/ACAT2/MCEE/SDHC/DLAT/ENO4/ADPGK/ALDOC/RGN/PCCB/GOT2/SDSL/ACOX3/FBP1/GLUD1	-0.460988022463249
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/1689	87/9376	0.893298762105034	TGFBR1/SMAD2/RAC2/AREG/POLK/APC/PIK3CB/MTOR/PIK3CD/TCF7L2/DDB2/LEF1/EGFR/CASP9	-0.468669428508665
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	26/1689	158/9376	0.913490867939235	CCNH/SMAD2/ORC3/CDKN1C/MTBP/PDS5A/CDKN2C/MAU2/CDC7/ANAPC7/EP300/PPP2R1B/CDC14B/ORC6/ANAPC10/CDC25B/ANAPC4/CDC27/TRIP13/CCND3/RBL2/CDC14A/ORC4/SKP1/ORC5/CDC16	-0.514036749686617
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1689	33/9376	0.841092990293701	DHTKD1/DLAT/BCAT2/DBT/GOT2	-0.428626357123092
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	24/1689	148/9376	0.900196822044069	WNT4/WNT6/WNT5A/ESR1/WNT9A/WNT3/POLK/NCOA1/APC/PIK3CB/WNT9B/PGR/MTOR/PIK3CD/WNT5B/PTEN/WNT10B/TCF7L2/DDB2/LRP5/LEF1/EGFR/HEYL/WNT1	-0.573645323736098
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1689	89/9376	0.873224632619528	SLC38A1/ADCY9/GNB5/GNGT1/PLCL1/GLUL/SLC38A2/GNG2/GNG7/GABARAPL2/ADCY7/ADCY2/TRAK2/GNGT2	-0.563266834884392
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/1689	71/9376	0.860047198525671	PRL/PRLR/ESR1/MAPK14/PIK3CB/PIK3CD/SOCS5/CISH/SOCS7/JAK2/TH	-0.554848740284278
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/1689	71/9376	0.860047198525671	PDGFRA/NTRK1/PIK3CB/SLC16A3/MTOR/PIK3CD/RET/PTEN/HIF1A/EGFR/SIRT6	-0.554848740284278
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1689	53/9376	0.837919054481272	ATP2B4/ESR1/ADCY9/ATP2B3/PLCB1/DNM2/FXYD2/ATP1B3	-0.554643690187506
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1689	28/9376	0.793030533705489	B3GNT2/ST3GAL6/B4GALT4/B4GALT3	-0.514100428711821
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/1689	78/9376	0.854032882452065	HLA-DRB1/MAPK14/HLA-DMA/C3/IRAK4/TAB2/IFNGR1/PTPN6/TRAF6/CYBA/JAK2/HLA-DMB	-0.606777662866096
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1689	41/9376	0.812372741844647	BABAM2/UIMC1/NBN/RBBP8/RAD51C/SYCP3	-0.564355447958711
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	10/1689	66/9376	0.841092990293701	CYP3A5/HSD11B1/CYP7B1/DHRS9/COMT/HSD17B6/HSD17B7/HSD17B12/SRD5A3/SULT2B1	-0.607242563456453
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/1689	66/9376	0.841092990293701	STAT4/HLA-DRB1/HLA-DMA/SMAD2/GATA3/IL18/IFNGR1/IL18R1/HLA-DMB/IL21R	-0.607242563456453
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	17/1689	109/9376	0.865785628540855	CCL3/MAPK14/CCL4/CCL5/IKBKB/IFNAR2/PIK3CB/IRAK4/STAT2/TAB2/PIK3CD/IRF9/IRF7/TRAF6/CHUK/MAP2K7/TIRAP	-0.66063976613048
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/1689	54/9376	0.822402034953841	MTR/BHMT2/KYAT1/CISD1/MRI1/BCAT2/GOT2/SDSL	-0.613482725452825
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/1689	54/9376	0.822402034953841	GZMB/HLA-DRB1/HLA-DMA/PRF1/HLA-E/FAS/HLA-DMB/TG	-0.613482725452825
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1689	35/9376	0.793030533705489	HSD17B14/ENOSF1/PMM2/ALDOC/FBP1	-0.574997078847149
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	22/1689	139/9376	0.878609368278024	KRT23/MMP9/CTSD/ESR1/ADCY9/CALM2/NCOA1/FKBP5/KRT18/PIK3CB/HSPA1B/PGR/PLCB1/PIK3CD/ADCY7/ADCY2/ATF6B/CREB3L1/HSPA1A/ITPR1/EGFR/CALML4	-0.675848139018055
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	26/1689	163/9376	0.88546967567116	TGFBR1/MMP9/STAT4/MAPK14/IFIH1/IKBKB/EP300/PIK3CB/IRAK4/STAT2/ATP6AP1/TAB2/PIK3CD/IRF7/SLC10A1/TRAF6/FAS/ATF6B/CREB3L1/CHUK/MAP2K7/DDB2/JAK2/CASP9/TIRAP/DDX3X	-0.691410195971196
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/1689	73/9376	0.836484261579763	POLK/FHIT/PIK3CB/PIK3CD/STK4/RET/DDB2/KIF5C/EGFR/CASP9/RARB	-0.657402728060576
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/1689	67/9376	0.828539363572899	ACSS1/GALM/DLAT/ENO4/ADPGK/ALDOC/ALDH3A2/ALDH7A1/G6PC3/FBP1	-0.660195165981425
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/1689	122/9376	0.864533286744509	IGFBP3/MAPK14/ADCY9/GHR/EP300/PIK3CB/PLCB1/MTOR/PIK3CD/ADCY7/ADCY2/IRS2/BCAR1/ATF6B/CREB3L1/IRS1/PTK2/ITPR1/JAK2	-0.705943240445288
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/1689	86/9376	0.839136960083715	NCK1/NRG2/ERBB3/AREG/CBL/PIK3CB/CAMK2G/MTOR/PIK3CD/MAP2K7/PTK2/EGFR/PAK4	-0.702456867375634
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	16/1689	105/9376	0.845899235952522	MAPK14/FCER1G/MRAS/CALM2/IKBKB/PIK3CB/STAT2/PPP3CB/PLK3/PIK3CD/IRF9/CLEC7A/PPP3CC/CHUK/ITPR1/CALML4	-0.744317403053547
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1689	23/9376	0.724071356861534	PDSS1/ACAT2/RCE1	-0.621022390496024
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/1689	56/9376	0.793030533705489	C3/RAB1A/IL18/HSPA1B/CLK4/HBS1L/HSPA1A/CASP9	-0.728139111551675
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	50/1689	308/9376	0.901171061028965	MAP3K5/DNAH14/GPX3/SLC1A2/DNAH11/DCTN4/POLR2K/KLC1/HIP1/POLR2A/TUBA3E/ATG2B/SLC25A4/EP300/TUBA4A/NDUFS4/SDHC/NDUFS8/POLR2J/DCTN6/TAF4/HTT/NDUFA4/PIK3C3/PLCB1/MTOR/UQCR10/GPX8/NDUFA7/POLR2J3/NDUFC2/NDUFB3/MT-CO2/PSMD3/ATG14/CREB3L1/COX7B/NDUFA13/DNAI1/PSMD1/MAP2K7/UQCR11/DNAH5/GRIA4/ITPR1/NDUFS2/KIF5C/DNALI1/CASP9/DNAH6	-0.826657780677335
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1689	50/9376	0.77716992303138	HLA-DRB1/HLA-DMA/IL15/LTBR/TNFSF13B/CCL28/HLA-DMB	-0.740513754014508
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	23/1689	149/9376	0.856898764607945	CNR1/MAPK14/ADCY9/GNB5/GNGT1/DAGLB/NDUFS4/NDUFS8/GNG2/NDUFA4/DAGLA/PLCB1/GNG7/NDUFA7/ADCY7/ADCY2/NDUFC2/NDUFB3/NDUFA13/GRIA4/ITPR1/NDUFS2/GNGT2	-0.825331231037886
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1689	44/9376	0.756983691264331	PARP4/POLE4/UNG/POLG2/POLB/RFC3	-0.757349626468353
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/1689	76/9376	0.803465145991088	PDGFRA/POLK/CALM2/PIK3CB/CAMK2G/MTOR/PIK3CD/PTEN/DDB2/EGFR/CALML4	-0.806356191151776
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/1689	150/9376	0.851186106177225	TGFBR1/WNT4/WNT6/WNT5A/WNT9A/SMAD2/WNT3/POLK/APC/PIK3CB/WNT9B/MTOR/PIK3CD/WNT5B/WNT10B/TCF7L2/DDB2/LRP5/LEF1/EGFR/JUP/WNT1/RARB	-0.861200765738573
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1689	24/9376	0.693901716992303	EXT2/NDST1/NDST2	-0.703778973966701
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1689	17/9376	0.653083968933932	GGT5/CSAD	-0.67105192827675
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	11/1689	77/9376	0.793030533705489	TGFBR1/RUNX1/POLK/CBL/IKBKB/PIK3CB/PIK3CD/GAB2/BCL2L1/CHUK/DDB2	-0.854782339974327
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1689	52/9376	0.747278772145557	SCARB1/ADCY9/INSR/LDLR/ADCY7/ADCY2/HSD17B7	-0.856572810421887
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1689	32/9376	0.693901716992303	GALM/GAA/GALE/G6PC3	-0.81300176839843
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1689	18/9376	0.616801526215381	MTR/CD320	-0.76276459311751
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	35/1689	227/9376	0.855914012149096	MAP3K5/PLD1/MAPK14/PTPRJ/MGST2/PRKD1/VEGFA/IKBKB/SLC25A4/NDUFS4/PIK3CB/SDHC/NDUFS8/MGST1/NDUFA4/GSTA1/PIK3CD/UQCR10/NDUFA7/NDUFC2/ARNT/NDUFB3/PTEN/MT-CO2/HIF1A/COX7B/CHUK/NDUFA13/MAP2K7/UQCR11/CYBA/PTK2/NDUFS2/EGFR/SLC26A6	-1.03007746358848
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1689	73/9376	0.760440237799784	PDGFRA/PDGFD/POLK/PDGFC/PIK3CB/PIK3CD/PTEN/MITF/DDB2/EGFR	-0.963132006285662
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/1689	54/9376	0.719601780584611	POLK/REV3L/ATRIP/FANCB/FANCC/RAD51C/POLH	-0.968589160435273
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/1689	41/9376	0.67697728487054	MAOB/MAOA/DMGDH/ALDH7A1/SDSL	-0.971605250164582
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1689	48/9376	0.693901716992303	PIK3CB/PLCB1/PIK3CD/FXYD2/ATP1B3/G6PC3	-0.996573342445555
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/1689	42/9376	0.660858778087908	SAT1/SLC40A1/TFRC/ATG5/CP	-1.03250782085083
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	41/1689	268/9376	0.849252847662222	MAOB/MAOA/MAP3K5/KLC1/SLC39A10/CALM2/TUBA3E/SLC39A11/SLC25A4/TUBA4A/NDUFS4/SLC39A6/SDHC/CAMK2G/NDUFS8/NDUFA4/MCU/UQCR10/NDUFA7/MFN2/NDUFC2/NDUFB3/PRKN/SLC39A2/MT-CO2/PSMD3/SLC39A4/BCL2L1/COX7B/SLC18A2/NDUFA13/PSMD1/UQCR11/GPR37/ITPR1/NDUFS2/KIF5C/SNCAIP/CALML4/TH/CASP9	-1.17361871255262
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	42/1689	275/9376	0.84782173421605	NCAM1/MAPK14/RAC2/KLC1/C1QB/CCL5/TUBA3E/SLC25A4/TUBA4A/NDUFS4/PIK3CB/SDHC/NDUFS8/HSPA1B/PPP3CB/NDUFA4/MCU/PIK3CD/UQCR10/NDUFA7/CSNK2A1/NDUFC2/NDUFB3/PPP3CC/GRIN2D/CAV2/MT-CO2/PSMD3/ATF6B/CREB3L1/COX7B/NDUFA13/PSMD1/UQCR11/RYR2/HSPA1A/CYBA/ITPR1/NDUFS2/KIF5C/C7/CASP9	-1.20059475787714
Organismal Systems	Digestive system	hsa04976	Bile secretion	12/1689	90/9376	0.740161831458457	SCARB1/ADCY9/ABCC3/SLC4A2/NCEH1/LDLR/ADCY7/ADCY2/FXYD2/ATP1B3/SLC10A1/AQP1	-1.16099910239172
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1689	12/9376	0.462601144661535	VKORC1L1	-0.873129536687212
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1689	29/9376	0.574263489924665	GNGT1/CALM2/CALML4	-1.07628130293366
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	20/1689	144/9376	0.771001907769226	MAP3K5/PUM2/DAB1/ATG2B/SLC25A4/PIK3CB/MCU/PIK3C3/PLCB1/ATXN2/MTOR/PIK3CD/GRIN2D/NFYA/PSMD3/ATG14/ATXN1/PSMD1/ITPR1/RELN	-1.2980374867141
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/1689	99/9376	0.728947258254541	MMP9/ESR1/MAPK14/ADCY9/NCOR1/CDKN2C/PIK3CB/MTOR/PIK3CD/ADCY7/ADCY2/PTK2/EGFR	-1.27083640122091
NA	NA	hsa04081	Hormone signaling	32/1689	219/9376	0.811136253653103	PRL/PRLR/ESR1/SMAD9/SLC40A1/VIPR2/ADCY9/GHR/GNB5/GNGT1/INSR/LEPR/ADIPOR1/NPR3/PIK3CB/SLC16A10/GNA13/IGF2/GNG2/PLCB1/PIK3CD/GNG7/ADCY7/ADCY2/NPR1/IRS2/RAMP3/IRS1/JAK2/AVPR1A/GNGT2/OXTR	-1.32561091989225
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1689	30/9376	0.555121373593843	PC/SDHC/DLAT	-1.14396122102952
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1689	38/9376	0.584338287993518	PTPRC/ZAP70/UNG/RFXAP	-1.20344683195521
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/1689	87/9376	0.701877598796812	CACNA2D3/SLC9A7/UQCR10/FXYD2/ATP1B3/MT-CO2/COX7B/UQCR11/TPM1/RYR2/CACNB4	-1.30945861691939
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	23/1689	168/9376	0.759987594801094	STAT4/IFNAR2/PYGL/GLUL/SLC25A4/EIF2AK2/CAMK2G/STAT2/XIAP/CHMP5/IRF9/IFNGR1/TRPM7/BIRC3/FAS/TNFSF10/RNF31/SQSTM1/PYGM/JAK2/ZBP1/GLUD1/TNFRSF10A	-1.47138965092421
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/1689	41/9376	0.541581827896432	MMP9/VEGFA/DAPK2/EGFR	-1.37885505237045
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/1689	78/9376	0.640524661839049	SERPING1/MAPK14/C3/C1QB/CALM2/IRAK4/TRAF6/CALML4/TIRAP	-1.49432015382281
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1689	26/9376	0.427016441226033	ACOX3/PLA2G2A	-1.3713397080421
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	14/1689	115/9376	0.675799933070765	MAOB/MAOA/KCND2/HTR2B/GNB5/GNGT1/ALOX15B/GNG2/PLCB1/GNG7/SLC18A2/HTR2A/ITPR1/GNGT2	-1.63966490298268
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1689	36/9376	0.462601144661535	CRPPA/UGDH/DCXR	-1.51424647647182
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1689	36/9376	0.462601144661535	RNASEH2C/POLE4/RFC3	-1.51424647647182
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9/1689	82/9376	0.609279556383486	UPP1/MGST2/CDA/CMPK1/MGST1/GSTA1/CDADC1/DPYD/NME7	-1.66568835642972
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	14/1689	117/9376	0.664247797462718	SMARCB1/CECR2/SS18/RBBP4/DPF3/BRD7/PBRM1/GATAD2A/BAZ1B/MEAF6/BAZ2B/INO80C/SS18L1/ACTR6	-1.71297798540664
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	29/1689	217/9376	0.741867273466426	ESR1/MGST2/KPNA1/RPS6KA2/ADCY9/KPNA6/PAQR7/VEGFA/PIK3CB/MGST1/PGR/XIAP/GSTA1/MTOR/PIK3CD/ADCY7/ADCY2/KPNA3/ARNT/CCND3/ATF6B/CREB3L1/ARRB2/PAQR5/JAK2/EGFR/RPS6KA1/WNT1/KPNA5	-1.80331223195782
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/1689	205/9376	0.731135467660183	HDAC9/C3/KAT2B/DLG1/RASA2/HDAC4/HDAC7/EP300/PIK3CB/EIF2AK2/LTBR/ACTN1/GTF2E2/HLA-E/PIK3CD/IRF9/IRF7/CCND3/RBL2/ATF6B/TRAF1/CREB3L1/ATP6V0D2/POLB/LYN/GTF2H2C/DDX3X	-1.82441704746523
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/1689	46/9376	0.482714237907689	ALAD/CP/HMOX2/PPOX	-1.64850641447302
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/1689	99/9376	0.616801526215381	CFH/KRT23/CAMP/HLA-DRB1/HLA-DMA/C3/MASP1/C1QB/KRT18/SELPLG/HLA-DMB	-1.79663399175319
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1689	70/9376	0.555121373593843	CYP3A5/MGST2/HSD11B1/SULT1A1/MGST1/GSTA1/CYP3A43	-1.75118109252977
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1689	63/9376	0.528687022470326	GGT5/ALOX15B/TBXAS1/LTA4H/LTC4S/PLA2G2A	-1.75936883148208
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/1689	65/9376	0.512419729471239	CACNA1G/PIK3CB/PLCB1/PIK3CD/ARRB2/ITPR1	-1.84895636253092
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/1689	68/9376	0.489812976700449	CYP3A5/DHRS3/DHRS9/ALDH1A2/HSD17B6/CYP26B1	-1.9791453921222
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/1689	60/9376	0.462601144661535	GNA13/PPP2R1B/PLCB1/ITPR1/LYN	-1.95740027393001
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1689	23/9376	0.241357118953845	RFC3	-1.70744947012859
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/1689	94/9376	0.531499187483466	MMP9/MAPK14/MAPK7/CCL2/IKBKB/USP25/TAB2/TRAF6/CHUK	-2.13981149214583
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1689	73/9376	0.456264142679871	MAOB/MAOA/CYP3A5/MGST2/MGST1/GSTA1	-2.18604911918601
NA	NA	hsa04082	Neuroactive ligand signaling	23/1689	199/9376	0.64159756747027	SLC1A1/GRM7/ADCY9/SLC1A2/HTR2B/GNB5/GRIK2/GNGT1/GRIK1/TACR1/GNG2/PLCB1/GNG7/ADCY7/ADCY2/GRIN2D/SLC18A2/P2RY13/GRIA4/GLRB/HTR2A/GNGT2/CHRM5	-2.39535090164934
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1689	41/9376	0.270790913948216	GRIN2D/GRIA4	-2.19335465678219
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1689	30/9376	0.185040457864614	PLA2G2A	-2.09558755483955
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1689	191/9376	0.581278925229154	HDAC9/MAOB/MAOA/GNB5/SLC29A1/GNGT1/HDAC4/PPP1CB/CALM2/HAT1/HDAC7/GNG2/GNG7/GRIN2D/ATF6B/CREB3L1/SLC18A2/GNGT2/CALML4/TH	-2.74046301840934
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/1689	46/9376	0.241357118953845	PSMD3/PSMD1	-2.41767268180813
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1689	79/9376	0.35134264151509	CYP3A5/MGST2/HSD11B1/MGST1/GSTA1	-2.71381039577985
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	24/1689	238/9376	0.559786259086228	ISG15/MAPK14/C3/MX1/MASP1/C1QB/CCL2/ADAR/IFIH1/IKBKB/IFNAR2/OAS3/PIK3CB/EIF2AK2/IRAK4/STAT2/TAB2/PIK3CD/IRF9/TRAF6/RPL36AL/CHUK/EGFR/C7	-3.22439707637102
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	17/1689	195/9376	0.483951966722837	HDAC9/CAMP/MAPK14/C3/RAC2/HDAC4/HAT1/SLC25A4/HDAC7/PIK3CB/PLCB1/SELPLG/MTOR/PIK3CD/CLEC7A/CLCN5/CYBA	-3.41337860238277
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	41/1689	370/9376	0.615134495063447	PRL/PRLR/CNR1/RXFP1/GRM7/GAL/LPAR1/VIPR2/C3/F2R/EDNRB/HTR2B/GHR/GRIK2/PGRMC2/ADM/LEPR/GRIK1/LYPD6/LYNX1/TACR1/PTGIR/GRIN2D/CYSLTR1/PTGER4/TSPO/GLRA2/P2RY13/GRIA4/GLRB/HTR2A/TMEM97/UTS2/PTGER3/PTGDR/AVPR1A/F2RL2/OXTR/UTS2B/PTGFR/CHRM5	-3.54051061398585
Genetic Information Processing	Transcription	hsa03040	Spliceosome	21/1689	243/9376	0.47973452038974	BCAS2/SF1/SNRPG/SNRNP40/HSPA1B/DDX46/CDC40/CCDC12/U2SURP/TRA2B/RP9/SNRNP27/CASC3/SF3A2/THOC2/HSPA1A/RBM22/ALYREF/USP39/SNRPA/PRPF3	-3.85162007118059
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	13/1689	183/9376	0.394348516760653	MDN1/GNL2/XPO1/EFL1/NVL/DROSHA/TCOF1/AK6/CSNK2A1/HEATR1/RCL1/REXO1/POP1	-3.87830287702972
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	29/1689	323/9376	0.498406186818001	MMP9/FOXP1/PDGFRA/ABCC1/ERBB3/WNT3/TIMP3/DICER1/MAPK7/STMN1/HDAC4/EZR/VEGFA/IKBKB/APC/EP300/PIK3CB/MTOR/CDC25B/PIK3CD/SLC45A3/PTEN/IRS2/PRKCE/IRS1/TPM1/HOXD10/EGFR/PAK4	-4.30010632920587
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1689	86/9376	0.129097993859033	PDE1A/PLCB1	-3.803055663646
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/1689	143/9376	0.271737735325657	HLA-DRB1/HLA-DMA/C3/C1QB/ACTN1/HLA-DMB/C7	-4.1134519701402
Genetic Information Processing	Translation	hsa03010	Ribosome	14/1689	222/9376	0.350076541906027	MRPL33/MRPS6/MRPS28/MRPL52/MRPS18A/MRPL53/MRPL32/MRPL48/DAP3/MRPL54/MRPL13/RPL36AL/MRPL39/MRPS9	-4.59362213793696
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/1689	449/9376	0.123635049798183	GRK3/NCALD/CALM2/PDE1A/CAMK2G/GNG7/OR3A2/ARRB2/RGS2/CALML4	-8.92025820075523