category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	41/1650	110/9376	2.11799449035813	ID3/ID1/PPP2CB/GREM2/THBS1/SMAD9/LEFTY2/BMPR2/FST/ACVR1C/SKIL/ZFYVE9/NCOR1/ZFYVE16/CHRD/SKI/RGMB/TGFBR2/RGMA/ACVR1/ACVR2A/RPS6KB2/SMAD2/TFRC/TGIF2/NEO1/TFDP1/BMPR1A/TGFBR1/BAMBI/LTBP1/SMAD4/LEMD3/SP1/SMURF1/SMAD6/ID2/E2F5/RBL1/TGFB2/ID4	5.45054734418929
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	37/1650	98/9376	2.14540507111936	DGKB/INPP4B/ITPR1/PIP4K2A/INPP5A/PTEN/PIK3C2A/MTM1/PIK3CA/PIK3R1/INPP5B/PIP5K1B/PIKFYVE/ITPKB/DGKD/PIK3C3/DGKE/PIP5K1A/PPIP5K2/INPP4A/PI4KA/DGKH/IMPA1/PRKCA/CALML4/PI4KB/PIK3C2G/CDS2/IMPA2/MTMR14/SYNJ1/ITPR3/MTMR4/PIK3CB/INPP5F/ITPKC/PPIP5K1	5.26738683204955
NA	NA	hsa04517	IgSF CAM signaling	84/1650	299/9376	1.59640012161751	SORBS1/UNC5C/ACTN1/MYLK/MPDZ/NCAM1/CD96/LRFN5/VCL/SLIT3/FOXO1/VAV3/TRPC6/NECTIN2/MBP/NLGN4X/PARD3/PPFIA2/LCP2/ACTN4/ERC1/EZR/RASA1/RAPGEF6/DOK2/ANK3/PIK3CA/PIK3R1/PTPRZ1/NRP1/PTPRS/NCAM2/PAK1/ABL1/CABLES1/PTK2/IQGAP1/MAPK8/NCK1/TJP2/CD2/CLMP/NFASC/TJP1/MYL12A/MAPK10/PMP22/ROBO2/ACTB/UNC5B/GRB2/PTPN6/PRKCA/MTSS2/NCK2/MYH10/ITGA5/ACTR3C/JAM3/CNTNAP2/SPTAN1/ITGAL/SLITRK4/CTNNB1/TUBA4A/ITGA4/LRRC4C/AFDN/KIRREL1/CD86/ACTR3B/NRP2/TUBA1A/MAGI2/IGSF5/SCN8A/PARD6G/PIK3CB/CD84/ANK2/CNTNAP1/GRIP1/VAV2/MAPK12	4.84342309372078
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	57/1650	184/9376	1.7603162055336	WNT5A/UNC5C/WNT4/SLIT3/SEMA3A/SEMA3B/PPP3CA/RAC2/TRPC6/PLXNC1/PARD3/BMPR2/RASA1/PIK3CA/SEMA6D/PIK3R1/EFNA5/NRP1/PAK1/ABL1/EPHA6/NFATC3/ARHGEF12/PTK2/RGMA/TRPC1/SEMA5A/NEO1/NCK1/ROCK2/RYK/MYL12A/LIMK2/SSH2/ROBO2/EPHA7/CFL2/UNC5B/FZD3/LRIG2/PRKCA/DPYSL2/NCK2/ENAH/CAMK2G/ABLIM1/CDK5/SEMA6A/LRRC4C/RGS3/SEMA4C/SEMA4B/PARD6G/PIK3CB/EPHB6/ABLIM2/EPHA2	4.8133607173265
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	38/1650	108/9376	1.99937149270483	KPNA1/RANBP2/RANBP17/NUP98/XPO4/POM121/NUP214/IPO11/NUP160/KPNA6/RBM8A/PNN/NCBP1/ALYREF/NXT1/NUP210/NMD3/MAGOH/NUP42/UPF3A/DDX19A/SEH1L/XPO1/XPO7/NUP54/NUP210L/UPF3B/NUP93/POM121C/DDX19B/XPO6/IPO7/NUP155/CSE1L/THOC3/NUP205/NUP85/NUP133	4.82720875523642
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	30/1650	78/9376	2.18554778554779	INPP4B/PIP4K2A/INPP5A/PTEN/PIK3C2A/MTM1/PIK3CA/INPP5B/PIP5K1B/PIKFYVE/ITPKB/PIK3C3/PIP5K1A/PPIP5K2/INPP4A/ALDH6A1/PI4KA/IMPA1/PI4KB/PIK3C2G/IMPA2/MTMR14/SYNJ1/MTMR4/PIK3CB/PLCH2/INPP5F/ITPKC/PPIP5K1/FIG4	4.85871978036343
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	33/1650	93/9376	2.01634408602151	SORBS1/ACTN1/CTNNA3/PTPRM/VCL/RAC2/NECTIN2/PARD3/CTNND1/ACTN4/NLK/TCF7L1/TGFBR2/IGF1R/IQGAP1/INSR/ROCK2/PTPN1/TJP1/MYL12A/CTNNA1/ACTB/TGFBR1/PTPN6/LEF1/SMAD4/HEG1/MAP3K7/WASF1/CTNNB1/EGFR/SMURF1/AFDN	4.55185398088072
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	38/1650	116/9376	1.86148380355277	ACTN1/CTNNA3/CLDN10/MMP9/VCL/VAV3/RHOH/RAC2/ITK/ARHGAP5/CTNND1/ACTN4/EZR/PIK3CA/PIK3R1/OCLN/TXK/CLDN5/CLDN4/CLDN3/PTK2/PTK2B/ROCK2/MYL12A/CTNNA1/ACTB/PRKCA/JAM3/CLDN12/ITGAL/RAPGEF3/CTNNB1/ITGA4/AFDN/PIK3CB/VAV2/CLDN20/MAPK12	4.31440466157296
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	77/1650	300/9376	1.45848888888889	HSPA1B/PDGFRA/IGF1/HSPA1A/CACNB2/MAP4K3/MAP3K20/PPP3CA/SOS1/IGF2/RAC2/RASA2/MAP3K2/CACNA2D1/CSF1R/MAP3K13/MEF2C/RASA1/MAP3K4/NLK/PDGFD/MAP2K4/EFNA5/CACNA1H/NGF/PAK1/CACNA1C/NFATC3/PRKACB/AREG/STK4/STMN1/NF1/TGFBR2/IGF1R/STK3/RELB/PLA2G4C/IRAK4/MAPK8/DUSP3/INSR/PTPN7/MAPK10/DUSP8/TGFBR1/NR4A1/MAP2K5/KITLG/GRB2/PPP5C/TEK/PRKCA/FAS/MAPK8IP3/MAP2K7/CACNA1D/MAP3K14/MAP3K7/IKBKB/RASGRP1/RPS6KA5/VEGFC/CASP3/GNG12/SRF/EGFR/FASLG/CHUK/MAP3K8/HSPA6/CACNA2D3/MAP3K5/TGFB2/EPHA2/MAP3K10/MAPK12	3.7298593696582
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	66/1650	250/9376	1.50016	HSPA1B/PDGFRA/RAB11FIP1/HSPA1A/IL2RB/WIPF1/RAB31/ITCH/GRK3/PARD3/NEDD4/EPS15/GRK5/VPS45/ARFGEF2/ZFYVE9/WASHC1/VPS36/VPS37B/ZFYVE16/MVB12B/WASHC2C/PIP5K1B/SMAP2/LDLR/CAPZB/PSD/EPS15L1/ARFGEF1/TGFBR2/ARF4/WWP1/AP2B1/AGAP1/PDCD6IP/IGF1R/CBL/SMAP1/SMAD2/TFRC/PIP5K1A/DNM2/RAB11FIP3/HLA-F/EHD4/ASAP2/TGFBR1/PLD1/STAMBP/IL2RG/RAB11FIP2/RABEP1/ACTR3C/STAM2/CYTH3/MVB12A/EGFR/SMURF1/DNM3/RAB5B/ACTR3B/CHMP1B/KIF5A/PARD6G/GIT2/HSPA6	3.70415359661179
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	45/1650	157/9376	1.62872032426173	ID1/WNT5A/CTNNA3/SERPINE1/TEAD1/WNT4/PPP2CB/PPP1CB/PARD3/BTRC/BMPR2/FBXW11/WNT6/AREG/TCF7L1/NKD1/TGFBR2/STK3/DLG1/FRMD6/SMAD2/BMPR1A/WWTR1/PATJ/PPP2R2D/CTNNA1/ACTB/TGFBR1/YWHAH/FZD3/WNT9A/APC/TEAD3/LEF1/SMAD4/CSNK1E/CTNNB1/ID2/LIMD1/BIRC3/WWC1/PARD6G/CRB2/PPP2R2B/TGFB2	3.6712645173346
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	41/1650	142/9376	1.64069995731968	KLHL13/HERC1/ITCH/UBE2W/BTRC/COP1/BIRC6/NEDD4/UBE4B/UBA6/UBE2G2/UBE3C/PIAS1/FBXW11/UBE2K/HUWE1/UBE2N/FANCL/WWP1/FBXW8/ERCC8/CBL/CUL5/PIAS2/HERC2/ANAPC10/MID1/WWP2/UBE2G1/ANAPC1/UBE2E3/PRPF19/UBE4A/UBE2D3/UBE2O/SMURF1/PRKN/BIRC3/ANAPC7/CDC23/UBE2H	3.55511939423814
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	31/1650	99/9376	1.77934496479951	DGKB/PDGFRA/PLPP1/SOS1/RAC2/HIF1A/CHPT1/PDGFD/PIK3CA/PIK3R1/PIP5K1B/SLC22A3/DGKD/DGKE/RPS6KB2/PLA2G4C/MAPK8/PIP5K1A/PLPP3/LYPLA1/MAPK10/PLD1/GRB2/MTOR/DGKH/PRKCA/SP1/WASF1/EGFR/PIK3CB/SLC22A5	3.60241557195441
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	40/1650	138/9376	1.64707949055775	CCL2/WIPF1/VAV3/RAC2/GNAQ/LCP2/MAP2K4/PIK3CA/ARHGEF7/PIK3R1/PIP5K1B/NFATC3/ARHGEF12/ELMO1/PTK2/SKAP2/IRAK4/MAPK8/PIP5K1A/PTK2B/PKN2/ROCK2/ZAP70/MAPK10/ACTB/ITGA5/ACTR3C/TICAM1/MAP2K7/DOCK1/MAP3K7/IKBKB/IL18/ITGA4/CHUK/ACTR3B/PIK3CB/GIT2/VAV2/MAPK12	3.53881987358401
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	47/1650	170/9376	1.57102317290553	ACTN1/CLDN10/MPDZ/PPP2CB/PARD3/NEDD4/ACTN4/EZR/RAPGEF6/PRKAA1/OCLN/PRKACB/CLDN5/CLDN4/CLDN3/PRKAG1/PRKCE/ARHGAP17/SYMPK/DLG1/MAPK8/ROCK2/PATJ/TJP2/PPP2R2D/TJP1/MYL12A/MAPK10/ACTB/MYH10/ACTR3C/MAP2K7/JAM3/CLDN12/CACNA1D/TUBA4A/EPB41L4B/AFDN/ACTR3B/CGNL1/TUBA1A/IGSF5/PARD6G/PRKAA2/MAP3K5/PPP2R2B/CLDN20	3.47210593117034
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	47/1650	170/9376	1.57102317290553	WNT5A/WNT4/ARID1B/SOS1/IGF2/ARID2/PTEN/SMARCA2/LRP6/PIK3CA/PIK3R1/PBRM1/WNT6/RB1/TCF7L1/POLK/ARID1A/LRP5/TGFBR2/SMARCC1/IGF1R/SMARCA4/RPS6KB2/SMAD2/MGST2/ACTB/TGFBR1/FZD3/GRB2/WNT9A/SMARCB1/MTOR/APC/PRKCA/LEF1/CDK6/SMAD4/SMARCD2/CTNNB1/SMARCD1/EGFR/E2F3/CDKN2A/GSTO2/PIK3CB/TXNRD3/TGFB2	3.47210593117034
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	44/1650	157/9376	1.59252653927813	SERPINE1/IGFBP3/ITPR1/FOXO1/PPP3CA/PPP1CB/ZFP36L1/BTRC/PTEN/HIPK3/MCU/ATR/PIK3CA/PIK3R1/FBXW11/RB1/NFATC3/SQSTM1/LIN52/TGFBR2/RBBP4/SMAD2/KIR2DL4/HLA-F/NBN/TGFBR1/MTOR/TRPM7/CDK6/CALML4/CACNA1D/MRE11/E2F3/RAD9A/CDKN2A/E2F5/LIN54/ITPR3/PIK3CB/LIN37/SLC25A4/RBL1/TGFB2/MAPK12	3.45991941931453
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	36/1650	122/9376	1.67678092399404	PTPRC/PPP2CB/PPP3CA/SOS1/VAV3/ITK/LCP2/PIK3CA/PIK3R1/PAK1/NFATC3/MALT1/DLG1/PPP2R3A/MAPK8/NCK1/PPP2R5E/PPP2R2D/ZAP70/MAPK10/GRB2/PTPN6/CD3E/NCK2/MAP2K7/MAP3K14/MAP3K7/IKBKB/RASGRP1/CHUK/MAP3K8/PIK3CB/PPP2R2B/VAV2/NFKBIE/MAPK12	3.47707081047132
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	54/1650	203/9376	1.51158083296014	PDGFRA/ACTN1/IGF1/MYLK/LAMA4/VCL/ITGA1/SOS1/THBS1/PARVA/VAV3/PPP1CB/RAC2/ARHGAP5/PTEN/ACTN4/PPP1R12B/ITGA9/PDGFD/PIK3CA/PIK3R1/PAK1/LAMB1/PIP5K1B/RAPGEF1/LAMA3/FLNB/ZYX/PTK2/IGF1R/COL4A4/MAPK8/PIP5K1A/EMP1/ROCK2/DIAPH1/MYL12A/MAPK10/ACTB/GRB2/PRKCA/ITGA5/TLN2/DOCK1/ITGB7/VEGFC/CTNNB1/EGFR/ITGA4/RELN/ITGA3/BIRC3/PIK3CB/VAV2	3.40531150209735
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	35/1650	119/9376	1.67130124777184	CCL2/MMP9/TNFAIP3/ITCH/MAP2K4/TAB3/PIK3CA/PIK3R1/MMP14/CREB1/IL15/MAPK8/TRAF5/MAPK10/CASP7/ATF6B/DAB2IP/FAS/MAP2K7/MAP3K14/MAP3K7/IKBKB/RPS6KA5/CREB5/VEGFC/CASP3/TRAF1/SELE/CREB3L2/CHUK/BIRC3/MAP3K8/PIK3CB/MAP3K5/MAPK12	3.40569743031128
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	14/1650	34/9376	2.33982174688057	RORA/PER3/BTRC/CRY2/PRKAA1/FBXW11/PER1/CREB1/PRKAG1/CLOCK/NR1D1/CSNK1E/DBP/PRKAA2	3.61673599199723
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	38/1650	133/9376	1.62354978354978	IGF1/FOXO1/SOS1/PTEN/NLK/PRKAA1/PIK3CA/PIK3R1/KLF2/STAT3/STK4/DEPP1/TGFBR2/IGF1R/PRKAG1/MAPK8/SGK3/INSR/SETD7/MAPK10/TGFBR1/GRB2/HOMER1/SMAD4/CSNK1E/IKBKB/PLK3/EGFR/CDKN1B/FASLG/HOMER2/CHUK/TNFSF10/PIK3CB/PRKAA2/S1PR4/TGFB2/MAPK12	3.34688457655063
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	46/1650	169/9376	1.54669535592613	CTSD/PPP2CB/ITPR1/HIF1A/PTEN/BIRC6/VPS41/PRKAA1/HMGB1/PIK3CA/PIK3R1/VAMP8/PRKACB/SQSTM1/UVRAG/PIK3C3/STX7/DAPK3/IGF1R/STX17/RPS6KB2/DAPK2/MAPK8/RAB1A/MAPK10/MAP1LC3A/MTOR/ATG7/ATG10/ATG2B/MAP3K7/VPS39/ATG4B/EIF2AK4/ATG16L2/ATG14/ATG9A/MTMR14/RRAGB/PRKCD/MTMR4/PIK3CB/PRKAA2/ULK2/PIK3R4/ATG9B	3.3142092400064
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	53/1650	204/9376	1.47631610219846	WNT5A/IGF1/MMP9/WNT4/ESR1/ITPR1/SOS1/IGF2/THBS1/VAV3/PPP1CB/HIF1A/PPP1R12B/EZR/ANK3/PIK3CA/PIK3R1/PAK1/WNT6/PRKACB/STAT3/ARHGEF12/PTK2/IGF1R/PLAUR/CBL/IQGAP1/RPS6KB2/SMAD2/HOXD10/ROCK2/ACTB/FZD3/GRB2/WNT9A/MTOR/PTPN6/PRKCA/ITGA5/FAS/DROSHA/TWIST1/CAMK2G/CASP3/CTNNB1/EGFR/FASLG/ITPR3/PIK3CB/ANK2/VAV2/TGFB2/MAPK12	3.17854659679178
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	16/1650	44/9376	2.06633608815427	CCNH/MNAT1/TAF15/TAF3/TAF2/GTF2F2/GTF2I/GTF2H3/TAF1/GTF2H2/ERCC3/TAF11/TAF7L/TAF5L/TAF4/GTF2H2C	3.27629756407255
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	54/1650	212/9376	1.44740994854202	ID1/PDGFRA/IGF1/CNR1/SKAP1/LPAR1/EVL/THBS1/VAV3/ADCY1/RAC2/PARD3/CTNND1/GNAQ/SIPA1L1/DOCK4/LCP2/CSF1R/RAPGEF6/PDGFD/PIK3CA/PIK3R1/EFNA5/NGF/P2RY1/RAPGEF1/PRKD1/ADCY3/IGF1R/ADCY9/INSR/MAGI3/ACTB/KITLG/TEK/APBB1IP/PRKCA/ENAH/TLN2/CALML4/PRKD2/ITGAL/SIPA1L3/VEGFC/RAPGEF3/CTNNB1/EGFR/AFDN/MAGI2/PARD6G/PIK3CB/VAV2/EPHA2/MAPK12	3.04495785083982
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	29/1650	98/9376	1.68153370439085	PLPP1/PTPRC/GAB2/VAV3/RAC2/PIK3CA/PIK3R1/PAK1/PIP5K1B/PRKCE/RPS6KB2/PLA2G4C/PIP5K1A/DNM2/PLPP3/LIMK2/ASAP2/CFL2/PLD1/PRKCA/ACTR3C/DOCK1/MARCKSL1/WASF1/ACTR3B/PRKCD/PIK3CB/VAV2/SCIN	3.13417650281401
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	30/1650	103/9376	1.65507502206531	PPP2CB/CPSF6/PPP1CB/PABPN1/PAPOLA/RNGTT/SYMPK/MSI2/FIP1L1/PPP2R3A/RBM8A/PPP2R5E/PNN/PPP2R2D/NCBP1/SMG7/ALYREF/WDR33/NXT1/MAGOH/UPF3A/NUDT21/DDX19A/SMG6/CSTF3/UPF3B/DDX19B/PAPOLG/PPP2R2B/CSTF1	3.0892267088868
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	26/1650	86/9376	1.71794221282593	CTNNA3/SGCE/CACNB2/ITGA1/DMD/CACNA2D1/ITGA9/DSG2/CACNA1C/TCF7L1/PKP2/RYR2/SLC8A1/SGCZ/CTNNA1/ACTB/LEF1/ITGA5/ITGB7/CACNA1D/CTNNB1/ITGA4/SNTB1/ITGA3/DES/CACNA2D3	3.09087268317026
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	51/1650	200/9376	1.44901818181818	CLDN10/LPAR1/WIPF1/SEC24D/EZR/ARHGEF11/SEC24B/TAB3/PAK1/ABL1/OCLN/ARHGEF12/ABI1/MYO6/CLDN5/CLDN4/CLDN3/IRAK4/MAPK8/NCK1/ROCK2/TJP1/RAB1A/MAPK10/ACTB/CASP7/MYO1D/PTPN6/NCK2/MYH10/ACTR3C/FAS/CYTH3/CLDN12/MAP3K7/IKBKB/IL18/CASP3/WASF1/TUBA4A/CYFIP2/FASLG/MYO1F/CHUK/ACTR3B/MYO1E/TUBA1A/TNFSF10/MYO1G/CLDN20/MAPK12	2.96621400276496
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	56/1650	224/9376	1.42060606060606	HLA-DRB1/IL2RB/B2M/PPP3CA/ADCY1/CDKN2C/PTEN/CRTC3/ATR/ETS2/MAP2K4/PIK3CA/PIK3R1/NRP1/STAT5B/ZFP36/LTBR/RB1/NFATC3/PRKACB/ADCY3/CREB1/IL15/TGFBR2/HLA-DMA/ADCY9/RELB/DLG1/SMAD2/MAPK8/POLB/HLA-F/MAPK10/TGFBR1/ATF6B/IL2RG/ANAPC10/CD3E/SMAD4/XPO1/TLN2/ANAPC1/MAP3K14/ITGAL/IKBKB/CREB5/SRF/E2F3/CDKN2A/CREB3L2/CHUK/ANAPC7/PIK3CB/CDC23/SLC25A4/TGFB2	2.94436595934355
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	46/1650	178/9376	1.46849165815458	WNT5A/WNT4/TBL1X/INVS/PPP3CA/LGR4/RAC2/BTRC/LRP6/NLK/MCC/DKK1/FBXW11/WNT6/NFATC3/DAAM1/PRKACB/TCF7L1/NKD1/LRP5/MAPK8/PRICKLE2/ROCK2/RYK/MAPK10/BAMBI/FZD3/WNT9A/APC/PRKCA/LEF1/SFRP1/SMAD4/CBY1/CTNNBIP1/CAMK2G/MAP3K7/CSNK1E/CTNNB1/PRICKLE1/GPC4/DAAM2/RSPO1/CELSR1/ZNRF3/TLE6	2.91618733367104
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	28/1650	97/9376	1.64028741018432	ITPR1/ADCY1/PER3/GNAQ/PRKG2/NOS1AP/CACNA1H/CACNA1C/PRKACB/PER1/GNB5/PRKG1/RYR2/ADCY3/CREB1/ADCY9/GRIA4/RASD1/PRKCA/GRIN2D/CALML4/CACNA1D/CAMK2G/RPS6KA5/GNG12/GNG7/GUCY1A1/ITPR3	2.92927739811086
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	57/1650	232/9376	1.39611285266458	PDGFRA/ACTN1/RGCC/ITGAD/MYLK/LPAR1/VCL/ITGA1/SOS1/VAV3/PIP4K2A/PPP1CB/RAC2/SPATA13/ACTN4/PPP1R12B/EZR/ITGA9/PDGFD/PIK3CA/ARHGEF7/PIK3R1/PAK1/PIP5K1B/ARHGEF12/C7/PIKFYVE/PTK2/IQGAP1/ABI2/PIP5K1A/ROCK2/DIAPH1/FGD3/MYL12A/LIMK2/SSH2/ACTB/CFL2/APC/MYH10/ENAH/ITGA5/ACTR3C/DOCK1/ITGB7/ITGAL/GNG12/WASF1/EGFR/ITGA4/CYFIP2/ITGA3/ACTR3B/PIK3CB/VAV2/SCIN	2.82322230370534
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	27/1650	93/9376	1.64973607038123	ITPR1/SOS1/ADCY1/GNAQ/MAP3K2/MAP3K4/MAP2K4/CACNA1C/PRKACB/ADCY3/MMP14/ADCY9/PLA2G4C/MAPK8/PTK2B/MAPK10/PLD1/GRB2/PRKCA/MAP2K7/CALML4/CACNA1D/CAMK2G/EGFR/ITPR3/PRKCD/MAPK12	2.90994335399127
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	38/1650	144/9376	1.49952861952862	ID3/MEIS1/ID1/WNT5A/IGF1/WNT4/JARID2/SMAD9/LEFTY2/BMPR2/ACVR1C/SKIL/PIK3CA/SMARCAD1/PIK3R1/WNT6/STAT3/IGF1R/PCGF5/ACVR1/ACVR2A/SMAD2/BMPR1A/KAT6A/FZD3/GRB2/WNT9A/APC/PCGF3/SMAD4/JAK2/SETDB1/TBX3/CTNNB1/ID2/PIK3CB/ID4/MAPK12	2.7915408140326
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	50/1650	201/9376	1.41353836876225	MITF/MEIS1/IGF1/GZMB/MMP9/IGFBP3/IL2RB/NR4A3/AFF1/FOXO1/RUNX1T1/ZBTB16/CDKN2C/TAF15/CSF1R/MEF2C/NCOR1/NUPR1/FLI1/POLK/FUT8/TGFBR2/PTK2/IGF1R/MAF/SUPT3H/ETV6/CCNT2/JMJD1C/ZEB1/WT1/KLF3/MLLT3/ITGB7/REL/NSD2/SS18L1/SP1/CDKN1B/TRAF1/MLF1/ID2/RARA/CD86/BIRC3/ERG/CDK9/PPARG/LDB1/ELANE	2.73880467778931
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	28/1650	99/9376	1.60715029078665	IGF1/MMP9/ESR1/SOS1/ADCY1/CDKN2C/PIK3CA/NCOR1/PIK3R1/RB1/PRKACB/ADCY3/PTK2/IGF1R/ADCY9/RPS6KB2/MAPK8/NOTCH2/MAPK10/GRB2/MTOR/SP1/EGFR/CDKN1B/E2F3/CDKN2A/PIK3CB/MAPK12	2.80646922843616
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	23/1650	77/9376	1.69734750098386	RAC2/PIK3CA/PIK3R1/RB1/STAT3/POLK/TGFBR2/RPS6KB2/SMAD2/MAPK8/MAPK10/TGFBR1/PLD1/MTOR/CDK6/SMAD4/IKBKB/EGFR/E2F3/CDKN2A/CHUK/PIK3CB/TGFB2	2.83940109862245
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	16/1650	48/9376	1.89414141414141	ACAT2/HIBADH/HIBCH/AUH/OXCT1/BCKDHB/PCCA/DLD/MCCC1/ALDH6A1/IVD/ACADSB/ACADM/DBT/ACSF3/ALDH7A1	2.87000609499403
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	55/1650	227/9376	1.37679882525697	PDGFRA/CCL3/CCL2/B2M/ITPR1/AKAP13/PPP3CA/SOS1/ADCY1/RAC2/GNAQ/ARHGEF11/PIK3CA/PIK3R1/RB1/NFATC3/PRKACB/STAT3/ARHGEF12/GNB5/ADCY3/CREB1/PTK2/ADCY9/RPS6KB2/TRAF5/PTK2B/ROCK2/HLA-F/GRB2/ATF6B/MTOR/PRKCA/CDK6/FAS/PTGER4/CALML4/IKBKB/CREB5/SP1/CASP3/GNG12/CTNNB1/EGFR/E2F3/FASLG/IL10RB/GNG7/CDKN2A/CREB3L2/CHUK/ITPR3/PIK3CB/PTGER3/MAPK12	2.65574219212899
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	20/1650	65/9376	1.74843822843823	ITPR1/ADCY1/PDE8A/GNAQ/CACNA1H/CACNA1C/LDLR/PRKACB/ADCY3/CREB1/ADCY9/NR4A1/ATF6B/CACNA1D/NCEH1/CREB5/SP1/SCARB1/CREB3L2/ITPR3	2.79810969032291
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	23/1650	78/9376	1.67558663558664	HSPD1/MTREX/PAN3/ZCCHC7/PARN/BTG2/LSM5/XRN1/PNPT1/PATL1/CNOT9/EXOSC8/TENT4B/PFKP/BTG3/DCP1A/NUDT16/CNOT10/LSM6/EXOSC10/DIS3L/EXOSC9/CNOT3	2.76875060599711
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	25/1650	87/9376	1.63288052943225	SOS1/RAC2/PIK3CA/PIK3R1/AREG/TCF7L1/POLK/TGFBR2/RPS6KB2/SMAD2/MAPK8/MAPK10/TGFBR1/GRB2/MTOR/APC/MSH3/LEF1/SMAD4/CASP3/CTNNB1/EGFR/PMAIP1/PIK3CB/TGFB2	2.74060936911937
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	35/1650	133/9376	1.49537480063796	KLRC1/GZMB/TYROBP/KLRC3/FCER1G/HCST/KLRC2/KLRD1/PPP3CA/SOS1/VAV3/KLRK1/RAC2/LCP2/PIK3CA/PIK3R1/PAK1/IFNAR2/KIR2DL4/PTK2B/ZAP70/GRB2/PTPN6/PRKCA/FAS/ITGAL/LAT2/CASP3/FASLG/KIR2DL1/TNFSF10/NCR3/PIK3CB/KIR3DL1/VAV2	2.6589092380539
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	29/1650	106/9376	1.55462550028588	PDGFRA/IGF1/MMP9/FOXO1/SOS1/PTEN/PDGFD/PIK3CA/PIK3R1/RB1/TCF7L1/CREB1/IGF1R/ZEB1/GRB2/MTOR/LEF1/HSP90AA1/IKBKB/CREB5/CTNNB1/EGFR/CDKN1B/E2F3/CREB3L2/CHUK/ERG/PIK3CB/SLC19A1	2.65376924967242
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	19/1650	62/9376	1.7413880742913	HSPA1B/IGF1/HSPA1A/FOXO1/ADCY1/PRKAA1/PIK3CA/PIK3R1/PRKACB/ADCY3/IGF1R/PRKAG1/ADCY9/RPS6KB2/INSR/MTOR/PIK3CB/HSPA6/PRKAA2	2.70659691328414
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	35/1650	134/9376	1.48421528720036	CALD1/PRKCH/ACTA2/MYLK/KCNMA1/ITPR1/PLA2G2A/CALCRL/ADCY1/PPP1CB/AVPR1A/GNAQ/KCNMB1/PPP1R12B/ARHGEF11/PPP1R14A/RAMP3/CACNA1C/PRKACB/ARHGEF12/RAMP1/PRKG1/ADCY3/PRKCE/ADCY9/PLA2G4C/ROCK2/PRKCA/MYH10/CALML4/CACNA1D/GUCY1A1/ITPR3/PRKCD/KCNMB3	2.60890444050107
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	27/1650	98/9376	1.56556586270872	ITPR1/NR4A2/ADCY1/GNAQ/CACNA1H/ATP2B4/CACNA1C/LDLR/PRKACB/PRKD1/ADCY3/CREB1/PRKCE/ADCY9/ATP1B3/NR4A1/ATF6B/ATP1A1/PRKCA/CALML4/CACNA1D/PRKD2/CAMK2G/CREB5/SCARB1/CREB3L2/ITPR3	2.60087392050513
NA	NA	hsa04518	Integrin signaling	39/1650	154/9376	1.43905548996458	PDGFRA/ACTN1/IGF1/ITGAD/FREM1/LAMA4/C3/VCL/ITGA1/THBS1/PARVA/FERMT1/RAC2/ACTN4/LIMS2/ITGA9/PDGFD/PIK3CA/PIK3R1/LAMB1/LAMA3/FLNB/PTK2/IGF1R/COL4A4/ACTB/MTOR/NCK2/ITGA5/TLN2/ITGB7/ITGAL/VEGFC/CTNNB1/EGFR/ITGA4/RELN/ITGA3/PIK3CB	2.53873559288886
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	19/1650	63/9376	1.71374699374699	ACAT2/SMYD3/NSD1/CAMKMT/SETD2/ASH1L/KMT2C/KMT5B/SMYD2/KMT5A/DLD/SETD7/PLOD1/TMLHE/NSD2/SETDB1/DLST/SETMAR/ALDH7A1	2.62675775855826
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	32/1650	122/9376	1.49047193243915	IGF1/PPP2CB/FOXO1/CAB39/PRKAA1/CAB39L/PIK3CA/PIK3R1/EEF2K/ACACA/CREB1/IGF1R/PRKAG1/RPS6KB2/PPP2R3A/PPP2R5E/INSR/PPP2R2D/TBC1D1/ACACB/PFKP/MTOR/MAP3K7/LEPR/CREB5/SREBF1/ADIPOR2/CREB3L2/PIK3CB/PRKAA2/PPP2R2B/PPARG	2.5198784114291
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	32/1650	122/9376	1.49047193243915	IGF1/IGFBP3/ITPR1/SOS1/ADCY1/GNAQ/GHR/MAP2K4/PIK3CA/PIK3R1/SOCS2/STAT5B/CACNA1C/PRKACB/STAT3/ADCY3/CREB1/PTK2/ADCY9/MAPK8/MAPK10/GRB2/ATF6B/MTOR/PRKCA/JAK2/CACNA1D/CREB5/CREB3L2/ITPR3/PIK3CB/MAPK12	2.5198784114291
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	39/1650	155/9376	1.42977126099707	WNT5A/WNT4/ITPR1/ADCY1/PDE8A/CDKN2C/GNAQ/CACNA1H/CACNA1C/WNT6/RB1/LDLR/PRKACB/TCF7L1/ADCY3/CREB1/ARNT/ADCY9/NR4A1/FZD3/ATF6B/WNT9A/RASD1/APC/LEF1/CDK6/CACNA1D/CAMK2G/NCEH1/CREB5/SP1/CTNNB1/EGFR/CDKN1B/SCARB1/E2F3/CDKN2A/CREB3L2/ITPR3	2.49324218901742
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	24/1650	86/9376	1.58579281183932	SOS1/MAP2K4/PIK3CA/PIK3R1/STAT5B/PAK1/ABL1/AREG/PTK2/CBL/RPS6KB2/MAPK8/NCK1/MAPK10/GRB2/MTOR/PRKCA/NCK2/MAP2K7/CAMK2G/EGFR/CDKN1B/PIK3CB/NRG2	2.52194531504815
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	41/1650	166/9376	1.40349032493611	MYLK/KCNMA1/MEF2A/ITPR1/PPP3CA/ADCY1/PPP1CB/TRPC6/GNAQ/KCNMB1/PRKG2/MEF2C/KCNJ8/ATP2B4/CACNA1C/NFATC3/RGS2/FXYD2/PDE3A/PRKG1/ADCY3/CREB1/GTF2I/PDE3B/PRKCE/ADCY9/SLC8A1/INSR/ROCK2/ATP1B3/ATF6B/ATP1A1/CALML4/CACNA1D/CREB5/SRF/CREB3L2/GUCY1A1/ITPR3/KCNMB3/SLC25A4	2.42386045236605
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	34/1650	133/9376	1.45264980633402	MAOB/PPP2CB/ITPR1/PPP3CA/PPP1CB/GNAQ/CACNA1C/PRKACB/GNB5/CREB1/GRIA4/PPP2R3A/MAPK8/PPP2R5E/MAOA/PPP2R2D/MAPK10/CLOCK/ATF6B/PRKCA/SLC18A2/GSK3A/CALML4/CACNA1D/CAMK2G/CREB5/GNG12/GNG7/CREB3L2/KIF5A/ITPR3/PPP2R2B/TH/MAPK12	2.42958412522165
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	27/1650	101/9376	1.51906390639064	SERPINE1/CCL2/FOXO1/F3/PIK3CA/PIK3R1/STAT5B/STAT3/TGFBR2/PRKCE/SMAD2/COL4A4/MAPK8/DIAPH1/MAPK10/TGFBR1/PRKCA/SMAD4/JAK2/VEGFC/CASP3/CDKN1B/SELE/PRKCD/PIK3CB/TGFB2/MAPK12	2.42367742108261
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	39/1650	158/9376	1.40262370540852	WNT5A/IGF1/WNT4/RICTOR/SOS1/PTEN/RNF152/CAB39/LRP6/PRKAA1/CAB39L/PIK3CA/PIK3R1/CLIP1/WNT6/GRB10/WDR59/LRP5/IGF1R/RPS6KB2/PRR5/INSR/LPIN1/DEPDC5/FZD3/GRB2/WNT9A/MTOR/PRKCA/SLC38A9/SEH1L/IKBKB/ATP6V1C1/CHUK/RRAGB/PIK3CB/PRKAA2/LPIN3/ULK2	2.35862985473284
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	35/1650	139/9376	1.43082624809243	HSPA1B/HSPA1A/MMP9/CTSD/ESR1/ITPR1/SOS1/ADCY1/NCOA1/NCOA2/GNAQ/FKBP5/KRT23/PIK3CA/PIK3R1/PRKACB/ADCY3/CREB1/PGR/ADCY9/GRB2/ATF6B/HSP90AA1/CALML4/CREB5/SP1/EGFR/KRT18/OPRM1/RARA/CREB3L2/ITPR3/PRKCD/PIK3CB/HSPA6	2.36479959068742
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	32/1650	125/9376	1.45470060606061	FCER1G/CTSD/CERS6/PPP2CB/GAB2/RAC2/GNAQ/PTEN/PIK3CA/PIK3R1/ABCC1/SPTLC3/PRKCE/SPTLC1/PPP2R3A/MAPK8/PPP2R5E/CERS4/ROCK2/ORMDL1/PPP2R2D/MAPK10/PLD1/PRKCA/SGPP1/SGPL1/PIK3CB/S1PR4/MAP3K5/PPP2R2B/MAPK12/S1PR2	2.36502892957399
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	36/1650	144/9376	1.42060606060606	C3/FOXO1/TRA2A/TRA2B/PRKAA1/MAP2K4/TAB3/ACACA/TCF7L1/PRKAG1/IRAK4/MAPK8/LPIN1/ACACB/MAPK10/IL17RA/LEF1/FAS/TICAM1/MAP2K7/MAP3K14/MAP3K7/IKBKB/CASP3/SREBF1/CTNNB1/FASLG/ADIPOR2/ACADM/CHUK/C4A/PRKAA2/MAP3K5/LPIN3/ALDH7A1/MAPK12	2.35049392348984
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	37/1650	149/9376	1.41107179174293	GRM7/DGKB/PDGFRA/PLPP1/FCER1G/LPAR1/GAB2/SOS1/ADCY1/AVPR1A/PDGFD/PIK3CA/PIK3R1/PIP5K1B/LPAR6/ADCY3/DGKD/DGKE/ADCY9/PLA2G4C/PIP5K1A/DNM2/INSR/PTK2B/PLPP3/PLD1/KITLG/GRB2/MTOR/DGKH/PRKCA/CYTH3/RAPGEF3/AGPAT1/EGFR/DNM3/PIK3CB	2.33738799036133
NA	NA	hsa04519	Cadherin signaling	88/1650	404/9376	1.23775577557756	WNT5A/PDGFRA/CDH13/ACTN1/CTNNA3/CDH3/PCDH7/TEAD1/MPDZ/WNT4/EVL/VCL/VAV3/PPP1CB/RAC2/LIMA1/CTNND1/ACTN4/KRT81/RERE/KRT23/LRP6/FAT1/DSG2/ADAM10/WNT6/DAAM1/TCF7L1/PCDH18/PKP2/LRP5/KRT86/PTK2/IGF1R/STK3/ABI2/PCDHB16/MAPK8/WWTR1/PTK2B/PRICKLE2/ROCK2/TJP1/RYK/MAPK10/CDH26/CTNNA1/ACTB/FAT4/YWHAH/FZD3/WNT9A/APC/MYO1D/TEAD3/TMC8/LEF1/ENAH/ACTR3C/TMC6/IKBKB/DSG3/WASF1/CTNNB1/PRICKLE1/EGFR/CYFIP2/KRT18/DAAM2/AFDN/LIMD1/LHFPL5/MYO1F/CHUK/DES/ACTR3B/MYO1E/WWC1/CDH23/SCN5A/MYO1G/CELSR1/PSENEN/PSEN2/VAV2/PCDHGB7/CDH20/MAPK12	2.2574980515603
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/1650	32/9376	1.95333333333333	HIBCH/ACACA/SUCLG2/BCKDHB/PCCA/DLD/ACSS3/ACACB/ALDH6A1/ACSS1/DBT	2.49633928380999
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	11/1650	32/9376	1.95333333333333	PPP2CB/PIK3C3/MTOR/ATG7/ATG10/ATG2B/ATG4B/ATG9A/ULK2/PIK3R4/ATG9B	2.49633928380999
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	57/1650	248/9376	1.30604105571848	KPNA1/PTPRC/ARHGEF26/RHOH/VPS41/PIK3C2A/MAP2K4/TAB3/PIK3CA/DCTN4/PAK1/TCF7L1/ABI1/ELMO1/MYO6/PIK3C3/IRAK4/MAPK8/DNM2/ROCK2/GSDMD/MYL12A/MAPK10/ACTB/CASP7/LEF1/DYNC2H1/ACTR3C/KLC1/MAP2K7/CYTH3/HSP90AA1/EXOC4/NOD1/MAP3K7/IKBKB/PIK3C2G/VPS39/IL18/CASP3/CTNNB1/TUBA4A/EXOC2/CYFIP2/RAB5B/RHOJ/CHUK/BIRC3/FYCO1/ACTR3B/TUBA1A/TNFSF10/KIF5A/CSE1L/FBXO22/PIK3CB/MAPK12	2.25718925674042
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	27/1650	103/9376	1.48956751985878	CCL3/SERPINE1/CCL2/C3/PPP2CB/ADCY1/GNAQ/MAP2K4/PIK3CA/PIK3R1/TGFBR2/SMAD2/IRAK4/MAPK8/PPP2R2D/MAPK10/TGFBR1/CD3E/FAS/TICAM1/IKBKB/FASLG/CHUK/PIK3CB/PPP2R2B/TGFB2/MAPK12	2.30872038653373
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	26/1650	99/9376	1.49235384144475	TPM1/IGF1/SGCE/CACNB2/ITGA1/DMD/CACNA2D1/ITGA9/PRKAA1/CACNA1C/RYR2/PRKAG1/SLC8A1/SGCZ/ACTB/ITGA5/ITGB7/CACNA1D/TPM2/ITGA4/SNTB1/ITGA3/DES/PRKAA2/CACNA2D3/TGFB2	2.27583833275733
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	24/1650	90/9376	1.51531313131313	IGF1/FOXO1/ADCY1/PRKAA1/PIK3CA/PIK3R1/PRKACB/ADCY3/CREB1/IGF1R/PRKAG1/ADCY9/RPS6KB2/SESN1/INSR/SESN3/ATF6B/MTOR/CREB5/ADIPOR2/CREB3L2/PIK3CB/PRKAA2/PPARG	2.27001320125465
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	28/1650	109/9376	1.45970530998054	FOXO1/PPP1CB/PTEN/PRKAA1/PIK3CA/PIK3R1/STAT3/CREB1/PRKAG1/PRKCE/RPS6KB2/MAPK8/INSR/PTPN1/ACACB/MAPK10/MTOR/GFPT1/IKBKB/PYGL/CREB5/SREBF1/SLC27A5/CREB3L2/PRKCD/PIK3CB/PPP1R3B/PRKAA2	2.23086580237391
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1650	29/9376	1.9594566353187	TEAD1/PAK1/STK3/FRMD6/WWTR1/FAT4/TEAD3/CSNK1E/LIMD1/WWC1	2.39132435287874
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	23/1650	86/9376	1.51971811134602	KCNMA1/ADCY1/GNAQ/KCNMB1/ABCC8/CACNA1C/PRKACB/FXYD2/RYR2/ADCY3/CREB1/ADCY9/ATP1B3/ATF6B/ATP1A1/PRKCA/CACNA1D/CAMK2G/CREB5/CREB3L2/ITPR3/VAMP2/KCNMB3	2.23748163098709
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	34/1650	138/9376	1.40001756697409	SORBS1/FOXO1/SOS1/INPP5A/PPP1CB/PRKAR2A/PRKAA1/PIK3CA/PIK3R1/SOCS2/ACACA/RAPGEF1/PRKACB/PDE3B/PRKAG1/CBL/RPS6KB2/MAPK8/INSR/PTPN1/ACACB/MAPK10/GRB2/MTOR/CALML4/IKBKB/PYGL/SREBF1/PHKA1/PRKAR2B/PIK3CB/PPP1R3B/PRKAA2/PRKAR1B	2.18766030518207
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	21/1650	77/9376	1.5497520661157	GAB2/SOS1/PIK3CA/PIK3R1/STAT5B/ABL1/RB1/POLK/TGFBR2/CBL/TGFBR1/GRB2/CDK6/SMAD4/IKBKB/CDKN1B/E2F3/CDKN2A/CHUK/PIK3CB/TGFB2	2.23843437926797
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	27/1650	105/9376	1.46119480519481	TPM1/IGF1/SGCE/CACNB2/ITGA1/DMD/ADCY1/CACNA2D1/ITGA9/CACNA1C/PRKACB/RYR2/ADCY3/ADCY9/SLC8A1/SGCZ/ACTB/ITGA5/ITGB7/CACNA1D/TPM2/ITGA4/SNTB1/ITGA3/DES/CACNA2D3/TGFB2	2.1961703515558
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	39/1650	163/9376	1.35959843837144	STAT4/MMP9/SOS1/MAP2K4/PIK3CA/PIK3R1/STAT5B/RB1/NFATC3/STAT3/CREB1/TGFBR2/IRAK4/MAPK8/PTK2B/MAPK10/TGFBR1/GRB2/ATF6B/PRKCA/SMAD4/FAS/TICAM1/MAP2K7/JAK2/MAP3K7/IKBKB/CREB5/CASP3/IRF7/E2F3/FASLG/EGR3/SLC10A1/CREB3L2/CHUK/PIK3CB/TGFB2/MAPK12	2.14023431070995
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	29/1650	115/9376	1.43295915678524	MEF2A/ITPR1/AKAP13/OXSR1/NR4A2/ADCY1/PDE4B/GNAQ/PDE4D/STK39/MEF2C/LRP6/ARHGEF11/PRKACB/LRP5/ADCY3/MMP14/CREB1/ADCY9/PLD1/ATF6B/BGLAP/PRKCA/CREB5/SP1/EGFR/CREB3L2/ITPR3/WNK3	2.15882364228796
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	53/1650	233/9376	1.29256860449993	TPM1/SGCE/CSRP1/SYNPO2/NID1/FBN2/VCL/ITGA1/DMD/PDLIM7/THBS1/FMNL2/LBR/ITGA9/DSG2/ANK3/NID2/NEB/FHL2/DAAM1/SDC3/PKP2/CAPZB/ZYX/PDLIM5/COL4A4/DIAPH1/ATP1B3/SGCZ/ACTB/ATP1A1/TMOD2/LMOD1/MYH10/ITGA5/TLN2/ITGB7/ELN/SPTAN1/TPM2/ITGA4/COL5A2/COL27A1/SNTB1/DAAM2/ITGA3/ANKRD23/COL24A1/DES/NEBL/FHL1/ANK2/TMOD1	2.08983298320487
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	21/1650	78/9376	1.52988344988345	CTNNA3/ARHGAP10/VCL/ARHGEF26/PIK3CA/PIK3R1/ELMO1/PTK2/CBL/DNM2/CTNNA1/ACTB/ITGA5/ACTR3C/DOCK1/WASF1/CTNNB1/DNM3/ACTR3B/SEPTIN1/PIK3CB	2.17161655617817
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	34/1650	140/9376	1.38001731601732	ACTA2/SERPINE1/MYLK/HDAC4/MEF2A/ITPR1/ADCY1/GNAQ/MEF2C/PRKAA1/KLF2/PRKACB/GNB5/RYR2/ADCY3/PDE3B/PIK3C3/PRKAG1/PRKCE/ADCY9/RPS6KB2/SMAD2/SLC8A1/TGFBR1/MAP1LC3A/MTOR/SMAD4/CALML4/PLIN1/GNG12/GNG7/ITPR3/PRKAA2/PIK3R4	2.09351318492673
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	22/1650	83/9376	1.50618473895582	SCMH1/JARID2/KDM2A/FOXK2/PCGF5/RBBP4/MGA/TFDP1/FOXK1/PCGF3/MBD5/KDM2B/YAF2/DCAF7/L3MBTL1/UBE2D3/L3MBTL3/MTF2/SFMBT1/USP45/SCML2/L3MBTL4	2.14052538903769
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	14/1650	47/9376	1.69263700838169	ABCC8/PIK3CA/PIK3R1/SOCS2/CACNA1C/PRKCE/MAPK8/INSR/MAPK10/MTOR/CACNA1D/IKBKB/PRKCD/PIK3CB	2.19982094887462
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/1650	30/9376	1.89414141414141	ABCC1/FPGS/DHFR/ABCC4/IKBKB/GART/CHUK/ABCC3/SLC19A1/ABCG2	2.26675304642027
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	16/1650	56/9376	1.62354978354978	GRK3/BTRC/FBXW11/PRKACB/MOSMO/DISP1/CSNK1G1/GLI3/KIF7/CSNK1E/EVC/SUFU/SMURF1/CSNK1G3/EFCAB7/SPOPL	2.16275561658642
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	24/1650	93/9376	1.46643206256109	FHIT/LAMA4/PTEN/PIK3CA/PIK3R1/CKS2/LAMB1/RB1/LAMA3/POLK/PTK2/COL4A4/TRAF5/CDK6/TRAF4/IKBKB/CASP3/CDKN1B/TRAF1/E2F3/ITGA3/CHUK/BIRC3/PIK3CB	2.08898804054654
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	37/1650	156/9376	1.34775446775447	CLDN10/PPP2CB/SOS1/PIAS1/PIK3CA/PIK3R1/OCLN/IFIT1/IFNAR2/RB1/LDLR/STAT3/CLDN5/CLDN4/CLDN3/PPP2R2D/RSAD2/YWHAH/GRB2/MX1/CDK6/FAS/TICAM1/CLDN12/IKBKB/OAS1/CASP3/CTNNB1/IRF7/EGFR/SCARB1/E2F3/FASLG/CHUK/PIK3CB/PPP2R2B/CLDN20	2.02404337583955
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	23/1650	89/9376	1.46849165815458	PDGFRA/LPAR1/ITPR1/SOS1/ADCY1/GNAQ/PRKG2/MAP3K2/PDGFD/HTR2A/PRKACB/PRKG1/ADCY3/ADCY9/TJP1/MAP2K5/GRB2/PRKCA/TUBA4A/EGFR/TUBA1A/GUCY1A1/ITPR3	2.05215141451499
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	34/1650	142/9376	1.36058045241144	CCL2/MMP9/MEF2A/RAC2/BMPR2/MEF2C/PRKAA1/MAP2K4/PIK3CA/PIK3R1/KLF2/SQSTM1/PTK2/ACVR1/ACVR2A/MGST2/MAPK8/BMPR1A/MAPK10/ACTB/MAP2K5/MAP2K7/HSP90AA1/CALML4/MAP3K7/IKBKB/CTNNB1/SELE/GSTO2/CHUK/PIK3CB/PRKAA2/MAP3K5/MAPK12	2.00079076782498
NA	NA	hsa03272	Virion - Hepatitis viruses	14/1650	48/9376	1.65737373737374	CLDN10/OCLN/LDLR/CLDN5/PDCD6IP/CLDN4/CLDN3/EPCAM/CLDN12/EGFR/SCARB1/SLC10A1/CHMP1B/CLDN20	2.11003159356316
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	25/1650	99/9376	1.4349556167738	PRKCH/IGF1/ITPR1/ADCY1/PPP1CB/GNAQ/HTR2A/PIK3CA/PIK3R1/NGF/PRKACB/ADCY3/PRKCE/ADCY9/PLA2G4C/MAPK8/MAPK10/PRKCA/PTGER4/CALML4/CAMK2G/ITPR3/PRKCD/PIK3CB/MAPK12	2.01052288491792
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	19/1650	71/9376	1.52064874093043	ADAM10/MAP2K4/PTPRZ1/PAK1/MAPK8/TJP1/MAPK10/ATP6V0A1/JAM3/MAP3K14/NOD1/IKBKB/ATP6V1C1/CASP3/EGFR/CHUK/IGSF5/ATP6V0A2/MAPK12	2.03500774536205
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	53/1650	238/9376	1.26541380188439	PDGFRA/IGF1/RALGAPA1/GAB2/PLA2G2A/SOS1/IGF2/RAC2/RASA2/CSF1R/RASA1/ETS2/PDGFD/PIK3CA/PIK3R1/EFNA5/NGF/PAK1/ABL1/PRKACB/STK4/GNB5/NF1/RALGAPB/IGF1R/PLA2G4C/MAPK8/RASAL3/INSR/ZAP70/RGL1/MAPK10/PLD1/KITLG/GRB2/TEK/PRKCA/REL/CALML4/IKBKB/RASGRP1/VEGFC/RASA3/GNG12/EGFR/EXOC2/FASLG/RAB5B/AFDN/GNG7/CHUK/PIK3CB/EPHA2	1.91662285702833
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	44/1650	193/9376	1.29547495682211	CCL3/CCL2/XCL1/CCL21/SOS1/VAV3/XCL2/ADCY1/RAC2/ITK/GRK3/PARD3/CCL8/CXCL13/GNAQ/GRK5/PIK3CA/PIK3R1/STAT5B/PAK1/PRKACB/STAT3/CCL14/GNB5/ELMO1/ADCY3/PTK2/ADCY9/PTK2B/ROCK2/CCL23/GRB2/PREX1/JAK2/GSK3A/CXCR3/IKBKB/GNG12/GNG7/CHUK/PRKCD/PIK3CB/VAV2/CCL28	1.91671392754152
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	36/1650	154/9376	1.32835891381346	TPM1/CACNB2/PPP2CB/ADCY1/PPP1CB/GNAQ/CREM/CACNA2D1/ATP2B4/CACNA1C/PRKACB/FXYD2/RYR2/ADCY3/CREB1/ADCY9/PPP2R3A/SLC8A1/PPP2R5E/PPP2R2D/ATP1B3/ATF6B/ATP1A1/PRKCA/CALML4/CACNA1D/CAMK2G/TPM2/RPS6KA5/CREB5/RAPGEF3/CREB3L2/SCN5A/CACNA2D3/PPP2R2B/MAPK12	1.89865855408801
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	31/1650	130/9376	1.35503962703963	ACTA2/MMP9/SOS1/ADCY1/MAP2K4/PIK3CA/PIK3R1/PRKACB/GNB5/ADCY3/CREB1/TGFBR2/ADCY9/SMAD2/COL4A4/MAPK8/MAPK10/TGFBR1/RXFP1/GRB2/ATF6B/PRKCA/MAP2K7/CREB5/VEGFC/GNG12/EGFR/GNG7/CREB3L2/PIK3CB/MAPK12	1.88374372519399
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	71/1650	333/9376	1.21156793156793	WNT5A/ISG15/MAML3/LAMA4/WNT4/PPP2CB/ITGA1/FOXO1/SOS1/THBS1/PARD3/PTEN/ATR/ITGA9/HES4/PIK3CA/PIK3R1/LAMB1/IFNAR2/WNT6/NFX1/RB1/LAMA3/PRKACB/TCF7L1/CREB1/PTK2/RPS6KB2/DLG1/COL4A4/PPP2R3A/NOTCH2/PPP2R5E/PATJ/PPP2R2D/HLA-F/FZD3/GRB2/WNT9A/MX1/MTOR/APC/LFNG/CDK6/ATP6V0A1/ITGA5/FAS/TICAM1/PTGER4/ITGB7/IKBKB/ATP6V1C1/UBR4/CREB5/CASP3/CTNNB1/OASL/EGFR/CDKN1B/ITGA4/FASLG/RELN/ITGA3/CREB3L2/CHUK/CHD4/PARD6G/PIK3CB/ATP6V0A2/PPP2R2B/RBL1	1.81662777451474
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	21/1650	82/9376	1.45525498891353	HSPA1B/KLRC1/HLA-DRB1/HSPA1A/CD74/KLRC3/B2M/KLRC2/KLRD1/PSME2/CREB1/HLA-DMA/KIR2DL4/HLA-F/HSPA5/HSP90AA1/RFXAP/KIR2DL1/NFYA/HSPA6/KIR3DL1	1.91342112403474
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	18/1650	68/9376	1.50417112299465	SOS1/RUNX1T1/ZBTB16/CSF1R/PIK3CA/PIK3R1/STAT5B/TCF7L1/STAT3/RPS6KB2/GRB2/MTOR/LEF1/IKBKB/RARA/PIM2/CHUK/PIK3CB	1.92821072775501
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/1650	50/9376	1.59107878787879	MAOB/CKB/OAT/MAOA/ARG1/PYCR2/SMS/AZIN2/ALDH18A1/SMOX/ARG2/CKMT2/SAT1/ALDH7A1	1.93656879281472
Organismal Systems	Immune system	hsa04611	Platelet activation	30/1650	126/9376	1.35295815295815	MYLK/FCER1G/ITPR1/ADCY1/PPP1CB/GNAQ/LCP2/PRKG2/PIK3CA/PIK3R1/VAMP8/P2RY1/PRKACB/TBXAS1/ARHGEF12/PRKG1/ADCY3/ADCY9/PLA2G4C/STIM1/ROCK2/MYL12A/ACTB/APBB1IP/TLN2/RASGRP1/GUCY1A1/ITPR3/PIK3CB/MAPK12	1.84326544954398
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	48/1650	216/9376	1.26276094276094	HSPA1B/APOA1/CCL3/CCL2/HSPA1A/MMP9/HSPD1/ITPR1/PPP3CA/VAV3/POU2F1/MAP2K4/PIK3CA/PIK3R1/NFATC3/LDLR/STAT3/PTK2/IRAK4/MAPK8/MIB1/ROCK2/MAPK10/HSPA5/CASP7/PRKCA/FAS/TICAM1/MAP2K7/HSP90AA1/JAK2/CALML4/CAMK2G/MAP3K7/IKBKB/IL18/CASP3/IRF7/SELE/FASLG/CHUK/TNFSF10/PIK3CB/HSPA6/MAP3K5/PPARG/VAV2/MAPK12	1.80546971746609
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	18/1650	69/9376	1.48237154150198	FCER1G/GAB2/SOS1/VAV3/RAC2/LCP2/MAP2K4/PIK3CA/PIK3R1/PLA2G4C/MAPK8/MAPK10/GRB2/PRKCA/MAP2K7/PIK3CB/VAV2/MAPK12	1.85845318093261
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	18/1650	69/9376	1.48237154150198	MAOB/PPP3CA/PPP1CB/CACNA1C/PRKACB/CREB1/GRIA4/MAOA/ATF6B/PRKCA/SLC18A2/GRIN2D/CALML4/CACNA1D/CAMK2G/CREB5/CREB3L2/TH	1.85845318093261
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	29/1650	122/9376	1.35074018877298	WNT4/ESR1/FOXO1/NCOA1/HIF1A/NCOA2/MED13L/PIK3CA/NCOR1/PIK3R1/MED14/PRKACB/FXYD2/NOTCH2/ATP1B3/PFKP/ACTB/MTOR/ATP1A1/PRKCA/RCAN1/MED30/CTNNB1/MED17/SLC16A2/THRA/PIK3CB/DIO3/MED12L	1.80198411214743
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	55/1650	253/9376	1.23530961791831	ACTN1/C3/VCL/ITPR1/FOXO1/BTRC/ACTN4/TAB3/PIK3CA/PIK3R1/GLMN/FBXW11/FNBP1L/SQSTM1/ELMO1/UBE2N/MALT1/PIK3C3/PTK2/PRKCE/RPS6KB2/MAPK8/TRAF5/ROCK2/DIAPH1/MYL12A/MAPK10/ACTB/MAP1LC3A/MTOR/ITGA5/ACTR3C/TLN2/CYTH3/GSK3A/DOCK1/NOD1/MAP3K7/IKBKB/RPS6KA5/IL18/UBE2D3/WASF1/EGFR/ATG14/CHUK/ACTR3B/RRAGB/RNF31/ITPR3/PRKCD/PIK3CB/PIK3R4/TECPR1/MAPK12	1.75340144536144
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	32/1650	137/9376	1.32728157487282	GZMB/CTSD/CTSW/PTPN13/ITPR1/PIK3CA/PIK3R1/NGF/MAPK8/MAPK10/ACTB/CASP7/CTSC/PARP4/DAB2IP/FAS/SPTAN1/MAP3K14/IKBKB/CTSK/CASP3/TUBA4A/TRAF1/FASLG/CHUK/BIRC3/TUBA1A/PMAIP1/TNFSF10/ITPR3/PIK3CB/MAP3K5	1.78328031156317
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	36/1650	158/9376	1.29472957422324	PPP2CB/CCNH/CDC7/CDKN2C/HDAC8/ATR/WEE1/ABL1/RB1/PDS5B/ORC3/SMAD2/RAD21/PDS5A/NIPBL/TFDP1/PPP2R5E/CDC14B/YWHAH/ORC4/ANAPC10/SMC1A/CDK6/SMAD4/ORC5/ANAPC1/MTBP/CDKN1B/E2F3/CDKN2A/E2F5/ANAPC7/SMC1B/CDC23/RBL1/TGFB2	1.72656990509368
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	54/1650	250/9376	1.22740363636364	MITF/CTSD/CTSW/LAPTM4A/OSBPL3/ACP5/GPR155/VPS13C/VPS41/GNPTAB/AP3B1/VAMP8/BORCS7/NPC2/PIKFYVE/SUMF1/BORCS5/AP2B1/STX17/PPT1/CD68/DMXL1/ACP2/CLN6/HGSNAT/TPCN1/CTSC/MTOR/OSBPL5/WDR7/OSBPL1A/ATP6V0A1/DTNBP1/GLB1/SLC38A9/ATP6V1C1/AGA/VPS39/SLC17A5/CTSK/OSTM1/ABCB9/SGSH/MFSD8/AP3M1/RRAGB/AP4E1/ATP6V0A2/AP3B2/NCOA7/SLC29A1/CLN8/LAMP5/FIG4	1.68413707117515
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	26/1650	109/9376	1.35544064498193	HLA-DRB1/IL2RB/RORA/PPP3CA/HIF1A/STAT5B/NFATC3/STAT3/TGFBR2/HLA-DMA/SMAD2/MAPK8/ZAP70/MAPK10/TGFBR1/IL2RG/MTOR/CD3E/SMAD4/HSP90AA1/JAK2/IKBKB/RARA/CHUK/NFKBIE/MAPK12	1.72488845016274
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	39/1650	174/9376	1.27364681295716	HSPA1B/HSPA1A/HSPH1/UGGT2/SEC24D/UBE4B/UBE2G2/SEC24B/PDIA6/PPP1R15A/SIL1/RPN1/BAG2/MAPK8/MAN1A2/SEC62/MAPK10/HSPA5/RRBP1/ATF6B/SEC61G/BCAP29/DNAJC10/DNAJB1/GANAB/MBTPS2/UBE2G1/MAP2K7/HSP90AA1/NGLY1/SEC61A2/STT3A/UBE2D3/PRKN/ERO1B/HSPA6/RNF5/MOGS/MAP3K5	1.68373663929566
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1650	154/9376	1.29146005509642	MYLK/CACNB2/ITPR1/PPP3CA/ADCY1/PPP1CB/GNAQ/PPP1R12B/CACNA2D1/MEF2C/PRKAA1/EEF2K/CACNA1C/NFATC3/PRKACB/RGS2/RYR2/ADCY3/PRKAG1/ADCY9/PLA2G4C/CD38/ROCK2/ACTB/MAP2K5/PRKCA/RCAN1/CALML4/CACNA1D/CAMK2G/EGFR/GUCY1A1/ITPR3/PRKAA2/CACNA2D3	1.6852995411544
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	33/1650	144/9376	1.30222222222222	RORA/ATXN1/ITPR1/DAB1/PUM2/GNAQ/MCU/PIK3CA/PIK3R1/OPA1/ATXN2/PIK3C3/MAPK8/MAPK10/MTOR/KCND3/PRKCA/ATXN2L/GRIN2D/AFG3L2/ATG2B/OMA1/SP1/RELN/ATG14/ITPR3/PIK3CB/NFYA/MAP3K5/SLC25A4/ULK2/PIK3R4/BEAN1	1.6889235876757
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	22/1650	90/9376	1.38903703703704	PPP3CA/HIF1A/PTEN/PIK3CA/PIK3R1/EML4/NFATC3/STAT3/RPS6KB2/ZAP70/MTOR/PTPN6/CD3E/TICAM1/JAK2/IKBKB/RASGRP1/EGFR/CHUK/PIK3CB/NFKBIE/MAPK12	1.71375258301819
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/1650	76/9376	1.42060606060606	PDGFRA/IGF1/SOS1/PTEN/PIK3CA/PIK3R1/RB1/POLK/IGF1R/GRB2/MTOR/PRKCA/CDK6/CALML4/CAMK2G/EGFR/E2F3/CDKN2A/PIK3CB	1.70133997546017
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	28/1650	120/9376	1.32589898989899	SOS1/ARHGDIB/PIK3CA/PIK3R1/NGF/ABL1/RAPGEF1/MATK/IRAK4/MAPK8/MAGED1/MAPK10/MAP2K5/GRB2/MAP2K7/PRDM4/CALML4/CAMK2G/IKBKB/RPS6KA5/FASLG/SH2B3/PRKCD/PIK3CB/MAP3K5/PSEN2/NFKBIE/MAPK12	1.66039808132174
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	75/1650	362/9376	1.17729784028127	PRL/PDGFRA/IGF1/LAMA4/IL2RB/PPP2CB/LPAR1/ITGA1/SOS1/IGF2/THBS1/PTEN/PRLR/CSF1R/GHR/ITGA9/PDGFD/PRKAA1/PIK3CA/PIK3R1/EFNA5/NGF/LAMB1/IFNAR2/LAMA3/AREG/GNB5/LPAR6/CREB1/PTK2/IGF1R/RPS6KB2/COL4A4/PPP2R3A/SGK3/PPP2R5E/INSR/PKN2/PPP2R2D/NR4A1/YWHAH/KITLG/GRB2/ATF6B/IL2RG/MTOR/TEK/PRKCA/CDK6/ITGA5/HSP90AA1/JAK2/ITGB7/IKBKB/CREB5/THEM4/VEGFC/GNG12/EGFR/CDKN1B/ITGA4/FASLG/RELN/OSM/IL7/PHLPP2/ITGA3/GNG7/CREB3L2/CHUK/MAGI2/PIK3CB/PRKAA2/PPP2R2B/EPHA2	1.58982459797862
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	43/1650	196/9376	1.24665429808287	C3/ITPR1/PPP3CA/HIF1A/MAP2K4/PIK3CA/PIK3R1/ZFP36/IFNAR2/RB1/NFATC3/TCF7L1/STAT3/GNB5/CREB1/PIK3C3/MAPK8/HLA-F/MAPK10/MAP1LC3A/MTOR/LEF1/CDK6/RCAN1/FAS/PREX1/TICAM1/MAP2K7/JAK2/CALML4/IKBKB/CASP3/GNG12/CTNNB1/IRF7/E2F3/GNG7/ATG14/CHUK/CD86/ITPR3/PIK3CB/MAPK12	1.61267049824668
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	27/1650	116/9376	1.32263322884013	GRM7/SLC38A1/ITPR1/PPP3CA/ADCY1/GRK3/GNAQ/CACNA1C/PRKACB/GNB5/ADCY3/GRIK1/ADCY9/GRIA4/TRPC1/PLA2G4C/SLC1A1/PLD1/HOMER1/PRKCA/GRIN2D/CACNA1D/GNG12/HOMER2/GNG7/GRIK2/ITPR3	1.61578232898363
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	41/1650	187/9376	1.24587911197537	ANTXR2/CCL2/GBP1/TNFAIP3/ITPR1/ANTXR1/TXNIP/MCU/GBP2/TAB3/NAMPT/TP53BP1/IFNAR2/GBP3/IRAK4/MAPK8/TRAF5/PKN2/GSDMD/MAPK10/MAP1LC3A/TRPM7/NEK7/GPSM3/TICAM1/HSP90AA1/CARD8/NOD1/MAP3K7/IKBKB/OAS1/IL18/BRCC3/IRF7/CAMP/CHUK/BIRC3/RNF31/ITPR3/PRKCD/MAPK12	1.56949006833375
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	12/1650	44/9376	1.5497520661157	ARHGDIB/DCTN4/PRKACB/ADCY3/CREB1/ADCY9/DYNC2H1/AQP3/CREB5/RAB5B/CREB3L2/VAMP2	1.68910287766435
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	32/1650	142/9376	1.28054630815194	MITF/TYROBP/GAB2/ITPR1/ACP5/PPP3CA/FOSL2/LCP2/CSF1R/PIK3CA/PIK3R1/FHL2/IFNAR2/SQSTM1/CREB1/TGFBR2/RELB/MAPK8/MAPK10/TGFBR1/GRB2/MAP2K7/MAP3K14/MAP3K7/IKBKB/CTSK/CHUK/ITPR3/PIK3CB/PPARG/TGFB2/MAPK12	1.55669687456408
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	13/1650	49/9376	1.50758194186766	GALNT17/GXYLT2/ST6GAL2/B4GALT1/GALNT13/ST6GAL1/LFNG/GALNT7/EOGT/GALNT18/B4GALT3/XXYLT1/GXYLT1	1.64620331890292
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	18/1650	73/9376	1.40114570361146	FHIT/SOS1/PIK3CA/PIK3R1/STAT5B/EML4/RB1/STAT3/POLK/STK4/GRB2/PRKCA/CDK6/EGFR/E2F3/CDKN2A/KIF5A/PIK3CB	1.59001903351399
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1650	31/9376	1.64973607038123	SEC11C/IMMP2L/IMMP1L/TMEM208/SEC62/HSPA5/SEC61G/SEC61A2/SGTA	1.67447408259184
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1650	18/9376	1.89414141414141	CBR4/ACACA/ACSL4/ACACB/ACSF3/MECR	1.75469323284021
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	50/1650	235/9376	1.20902643455835	CNR1/MT-ATP6/MT-CO2/ARID1B/SOS1/ADCY1/ZNF516/MT-ND4/COA1/SMARCA2/KDM3B/PRKG2/PRKAA1/NDUFA4/PRKACB/MT-ND5/ARID1A/NDUFAF8/PRKG1/ADCY3/NDUFS8/CREB1/SMARCC1/PRKAG1/SMARCA4/ADCY9/RPS6KB2/NDUFS2/ACSL4/KDM1A/NDUFA5/ACTB/NDUFS4/GRB2/SMARCB1/MTOR/ATP5MC3/NDUFA3/COX10/SMARCD2/PLIN1/CREB5/COX20/SMARCD1/CREB3L2/PRKAA2/MAP3K5/NDUFAF6/PPARG/MAPK12	1.49964528971973
Organismal Systems	Digestive system	hsa04970	Salivary secretion	22/1650	93/9376	1.344229390681	KCNMA1/ITPR1/ADCY1/GNAQ/PRKG2/ATP2B4/PRKACB/FXYD2/PRKG1/ADCY3/ADCY9/CD38/ATP1B3/ATP1A1/PRKCA/BST1/CALML4/PRH1/CAMP/GUCY1A1/ITPR3/VAMP2	1.54168449825005
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	14/1650	55/9376	1.44643526170799	PLPP1/CERS6/ACER3/B4GALT5/SPTLC3/SPTLC1/SAMD8/CERS4/PLPP3/B4GALT6/GLB1/UGCG/SGPP1/SGPL1	1.53447154450837
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	24/1650	104/9376	1.31132867132867	DGKB/PLPP1/PLA2G2A/LCLAT1/CHPT1/SELENOI/CEPT1/DGKD/DGKE/PLA2G4C/SAMD8/PLPP3/LYPLA1/LPIN1/MBOAT2/PLD1/DGKH/CDS2/MBOAT1/AGPAT1/LPCAT1/GPD2/LPIN3/CRLS1	1.47536451852286
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	35/1650	160/9376	1.2430303030303	HLA-DRB1/CLDN10/CDH3/PTPRC/NCAM1/PTPRM/NECTIN2/NLGN4X/ITGA9/PTPRS/NCAM2/OCLN/SDC3/CLDN5/CLDN4/HLA-DMA/CLDN3/NEO1/CD2/NFASC/HLA-F/JAM3/ITGB7/CNTNAP2/CLDN12/ITGAL/SLITRK4/NRXN1/ITGA4/SELE/LRRC4C/CD86/CNTNAP1/CLDN20/CD22	1.43284576730042
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1650	75/9376	1.36378181818182	IGF1/SERPINE1/IGFBP3/THBS1/RPRM/COP1/PTEN/ATR/MDM4/SESN1/SESN3/CDK6/FAS/CASP3/CDKN2A/PMAIP1/PERP/STEAP3	1.46169599543009
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	13/1650	51/9376	1.44846108140226	KDELR1/PRKACB/ADCY3/ADCY9/TJP2/TJP1/ACTB/SEC61G/PRKCA/ATP6V0A1/ATP6V1C1/SEC61A2/ATP6V0A2	1.48400609976181
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	23/1650	100/9376	1.30695757575758	CCL3/CCL2/IL2RB/XCL1/CCL21/XCL2/CCL8/CXCL13/ACKR3/CSF1R/LTBR/CCL14/CCL23/IL2RG/CXCR3/IL18/IL10RB/ACKR4/TNFSF10/IL20RB/TNFSF14/CCL28/IL34	1.4260943022292
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1650	19/9376	1.79444976076555	BCKDHB/DLD/OGDH/DLST/DBT/DLAT	1.60186230884734
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	14/1650	56/9376	1.42060606060606	ST6GAL2/ALG13/MGAT5/B4GALT1/FUT8/RPN1/ST6GAL1/MAN1A2/ALG8/GANAB/STT3A/ALG9/B4GALT3/MOGS	1.45885403851386
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/1650	28/9376	1.62354978354978	MOCOS/GPHN/PTS/MOCS2/FPGS/DHFR/PCBD1/TH	1.52700709527408
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1650	15/9376	1.89414141414141	ST6GALNAC3/ST8SIA1/ST6GALNAC5/GLB1/ST3GAL5	1.60155174866407
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	34/1650	157/9376	1.23058868944219	GULP1/XKR6/THBS1/ATP11A/HIF1A/VPS41/ANO4/VPS8/ADAM10/NFATC3/DNMT3A/ELMO1/CREB1/ARNT/PTK2/ATP11B/MFGE8/DUSP8/CASP7/PTPN6/ATP11C/ARG1/JAK2/DOCK1/PTGER4/CAMK2G/VPS39/CASP3/ATP8A1/RAB5B/ARG2/GPR132/PPARG/MAPK12	1.3464684391138
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	43/1650	205/9376	1.19192313377679	ACTN1/HDAC4/C3/RASA2/ACTN4/HDAC8/PIK3CA/PIK3R1/STAT5B/MRPS18B/LTBR/RB1/PRKACB/STAT3/CREB1/DLG1/GTF2H3/TRAF5/POLB/SP100/HLA-F/YWHAH/GRB2/ATF6B/GTF2H2/CDK6/REL/UBR4/CREB5/CASP3/SRF/IRF7/CDKN1B/TRAF1/EGR3/CDKN2A/CREB3L2/CHD4/PMAIP1/PIK3CB/SCIN/RBL1/GTF2H2C	1.28394425538602
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/1650	20/9376	1.70472727272727	UGP2/GMDS/CYB5R4/TGDS/UAP1/CYB5R2	1.45794529450742
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1650	53/9376	1.3938021726701	ESR1/GNAQ/ATP2B4/PRKACB/FXYD2/AP2B1/ADCY9/SLC8A1/DNM2/ATP1B3/ATP1A1/PRKCA/DNM3	1.32858228992202
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	9/1650	34/9376	1.50417112299465	POLR2K/POLR2A/POLR3GL/POLR2J3/POLR1A/POLR3C/POLR3B/POLR3A/POLR3E	1.36096749504616
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/1650	59/9376	1.34837185413457	ADCY1/PRKG2/PIK3CA/PIK3R1/PRKACB/PRKG1/ADCY3/PDE3B/ADCY9/INSR/FABP4/PLIN1/PIK3CB/PTGER3	1.24045574967097
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	14/1650	59/9376	1.34837185413457	CTNNA3/SOS1/PTEN/PIK3CA/PIK3R1/TCF7L1/POLK/CTNNA1/GRB2/APC/LEF1/CTNNB1/EGFR/PIK3CB	1.24045574967097
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1650	30/9376	1.51531313131313	PIGL/PIGU/PIGF/PGAP1/PIGM/PIGG/PIGB/GPLD1	1.30637904898527
Organismal Systems	Endocrine system	hsa04924	Renin secretion	16/1650	69/9376	1.3176635924462	KCNMA1/REN/ITPR1/PPP3CA/GNAQ/PRKG2/CACNA1C/PRKACB/PDE3A/CREB1/PDE3B/PTGER4/CALML4/CACNA1D/GUCY1A1/ITPR3	1.22387591939999
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	23/1650	105/9376	1.2447215007215	FCER1G/ITPR1/PPP3CA/PIK3CA/PIK3R1/PAK1/NFATC3/ARHGEF12/MALT1/RELB/MAPK8/MAPK10/CALML4/MAP3K14/IKBKB/PLK3/EGR3/CHUK/CLEC7A/ITPR3/PRKCD/PIK3CB/MAPK12	1.16534292715155
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/1650	45/9376	1.38903703703704	KLRC1/HLA-DRB1/GZMB/KLRD1/HLA-DMA/HLA-F/FAS/FASLG/KIR2DL1/CD86/KIR3DL1	1.20888049249111
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1650	80/9376	1.27854545454545	PDGFRA/IGF1/SOS1/PTEN/PDGFD/PIK3CA/PIK3R1/STAT3/NF1/IGF1R/RPS6KB2/GRB2/MTOR/PRKCA/JAK2/EGFR/PIK3CB/NRG2	1.15622743516902
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	17/1650	75/9376	1.28801616161616	GPX3/ITPR1/ADCY1/GNAQ/PRKACB/FXYD2/ADCY3/CREB1/ADCY9/ATP1B3/HSPA5/ATF6B/ATP1A1/PRKCA/CREB5/CREB3L2/ITPR3	1.15726528653248
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	31/1650	148/9376	1.19023751023751	WNT5A/IGF1/WNT4/ESR1/SOS1/NCOA1/PTEN/LRP6/PIK3CA/PIK3R1/WNT6/RB1/TCF7L1/POLK/LRP5/IGF1R/PGR/RPS6KB2/NOTCH2/FZD3/GRB2/WNT9A/MTOR/APC/LEF1/CDK6/SP1/CTNNB1/EGFR/E2F3/PIK3CB	1.07801170541345
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	37/1650	180/9376	1.16805387205387	BST2/HLA-DRB1/CCL2/CD74/C3/B2M/PPP1CB/POU2F1/NECTIN2/PIK3CA/PIK3R1/IFNAR2/HLA-DMA/IRAK4/TRAF5/SP100/HLA-F/ALYREF/SRSF1/MTOR/ZC3HAV1/ITGA5/FAS/TICAM1/JAK2/MAP3K7/IKBKB/OAS1/CASP3/IRF7/FASLG/CHUK/BIRC3/SRSF7/PIK3CB/PILRB/TNFSF14	1.05204799485739
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	29/1650	138/9376	1.19413263065437	SPDYE2/IGF1/PPP2CB/ITPR1/PPP3CA/ADCY1/PPP1CB/BTRC/FBXW11/PRKACB/ADCY3/IGF1R/PGR/ADCY9/PPP2R5E/SPDYA/YWHAH/ANAPC10/SMC1A/SPDYE5/ANAPC1/CALML4/CAMK2G/ANAPC7/ITPR3/SPDYE3/SMC1B/CDC23/MAPK12	1.06169399818045
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	16/1650	71/9376	1.28054630815194	PRL/ESR1/SOS1/PRLR/PIK3CA/PIK3R1/SOCS2/STAT5B/STAT3/MAPK8/MAPK10/GRB2/JAK2/PIK3CB/TH/MAPK12	1.096543341297
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	12/1650	51/9376	1.33704099821747	PLA2G7/PLPP1/PLA2G2A/CHPT1/SELENOI/CEPT1/AGPS/PLA2G4C/PLPP3/PLD1/ENPP2/LPCAT1	1.1153050241519
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	43/1650	214/9376	1.14179552534693	BST2/B2M/ITPR1/PPP3CA/RAC2/BTRC/GNAQ/ATR/WEE1/PIK3CA/PIK3R1/PAK1/FBXW11/NFATC3/GNB5/PTK2/CUL5/RPS6KB2/IRAK4/MAPK8/TRAF5/PTK2B/HLA-F/LIMK2/MAPK10/CFL2/MTOR/PRKCA/CD3E/FAS/MAP2K7/CALML4/MAP3K7/IKBKB/CASP3/GNG12/FASLG/GNG7/CHUK/ITPR3/TRIM5/PIK3CB/MAPK12	0.969671267966583
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	20/1650	93/9376	1.22202671880091	HLA-DRB1/STAT4/MAML3/IL2RB/PPP3CA/STAT5B/NFATC3/HLA-DMA/MAF/MAPK8/NOTCH2/ZAP70/MAPK10/IL2RG/CD3E/JAK2/IKBKB/CHUK/NFKBIE/MAPK12	0.994380955953566
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1650	18/9376	1.57845117845118	LMBRD1/MMAB/CD320/ZNF76/TCN2	1.13517207938676
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	6/1650	23/9376	1.48237154150198	B4GALT1/LARGE1/FKTN/CRPPA/B4GALT3/B3GAT2	1.07033662641422
Human Diseases	Infectious disease: viral	hsa05162	Measles	28/1650	136/9376	1.16991087344029	HSPA1B/HSPA1A/IL2RB/TNFAIP3/PIK3CA/PIK3R1/STAT5B/IFNAR2/ADAR/STAT3/IRAK4/MAPK8/MAPK10/IL2RG/MX1/CD3E/CDK6/FAS/MAP3K7/IKBKB/OAS1/CASP3/IRF7/CDKN1B/FASLG/CHUK/PIK3CB/HSPA6	0.922369427133267
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1650	63/9376	1.26276094276094	CCNH/MNAT1/POLR2K/POLR2A/ERCC8/POLR2J3/GTF2H3/GTF2H2/RFC3/ERCC3/LIG1/UVSSA/POLE2/GTF2H2C	0.9670224198353
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	23/1650	110/9376	1.18814325068871	SPDYE2/IGF1/ADCY1/PIK3CA/PIK3R1/PRKACB/ADCY3/PDE3B/IGF1R/PGR/ADCY9/MAPK8/MAPK10/SPDYA/ANAPC10/SPDYE5/HSP90AA1/ANAPC1/ANAPC7/PIK3CB/SPDYE3/CDC23/MAPK12	0.917252906174849
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/1650	33/9376	1.37755739210285	VAMP8/VAMP1/VTI1A/STX7/STX17/VAMP2/VAMP4/STX19	1.00403079067476
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9/1650	38/9376	1.34583732057416	IGF1/PIK3CA/PIK3R1/FXYD2/INSR/ATP1B3/ATP1A1/PRKCA/PIK3CB	0.987158705242744
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1650	14/9376	1.62354978354978	B4GALT1/FUT8/B3GNT2/B4GALT3	1.07894943181501
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	21/1650	101/9376	1.18149414941494	MITF/WNT5A/WNT4/ADCY1/GNAQ/WNT6/PRKACB/TCF7L1/ADCY3/CREB1/ADCY9/FZD3/KITLG/WNT9A/PRKCA/LEF1/CALML4/CAMK2G/CTNNB1/CREB3L2/ASIP	0.84745494067264
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1650	49/9376	1.2756462585034	MAOB/PRKACB/CREB1/MAOA/ATF6B/SLC18A2/GRIN2D/CREB5/CDK5/CREB3L2/TH	0.893983312175799
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	24/1650	117/9376	1.16562548562549	CECR2/ARID1B/ARID2/SMARCA2/MORF4L2/PBRM1/BAZ2B/ARID1A/SMARCC1/GATAD2B/EP400/SMARCA4/RBBP4/GATAD2A/ACTB/SMARCB1/SMARCD2/SMARCA1/SS18L1/TFPT/SMARCD1/CHD4/INO80E/CHRAC1	0.833083075963751
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/1650	44/9376	1.29146005509642	ALG13/B4GALT1/FUT8/RPN1/MAN1A2/HEXD/STT3A/B4GALNT3/ALG9/B4GALT3	0.895505534460255
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/1650	24/9376	1.42060606060606	EXT2/HS6ST2/HS2ST1/HS6ST3/NDST1/GLCE	0.953408800566273
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	15/1650	70/9376	1.21766233766234	PRKAA1/STAT3/PRKAG1/ACSL4/MAPK8/ACACB/MAPK10/MTOR/JAK2/IKBKB/LEPR/ADIPOR2/CHUK/PRKAA2/NFKBIE	0.844697178305335
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/1650	70/9376	1.21766233766234	HLA-DRB1/SGCE/DMD/RAC2/ABL1/CD55/HLA-DMA/EIF4G3/HLA-F/SGCZ/ACTB/ITGAL/CASP3/SNTB1/CD86	0.844697178305335
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1650	65/9376	1.22390675990676	DGKB/PLPP1/LCLAT1/DGKD/DGKE/AGK/PLPP3/LPIN1/MBOAT2/DGKH/MBOAT1/AGPAT1/LPIN3/ALDH7A1	0.837097372659952
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	30/1650	150/9376	1.13648484848485	WNT5A/CTNNA3/WNT4/SOS1/LRP6/PIK3CA/PIK3R1/WNT6/RB1/TCF7L1/POLK/LRP5/TGFBR2/RPS6KB2/SMAD2/CTNNA1/TGFBR1/FZD3/GRB2/WNT9A/MTOR/APC/LEF1/SMAD4/CTNNB1/EGFR/CDKN1B/E2F3/PIK3CB/TGFB2	0.778706150206898
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	10/1650	45/9376	1.26276094276094	ABCC9/ABCC8/ABCC1/ABCD3/ABCB7/ABCC4/ABCB10/ABCB9/ABCC3/ABCG2	0.816494440507564
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/1650	20/9376	1.42060606060606	LBR/HSD17B7/SC5D/MSMO1/EBP	0.870153108348942
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/1650	56/9376	1.21766233766234	HSPA1B/HSPA1A/HSPD1/C3/RAB1A/CASP7/CLK1/HSF1/IL18/CASP3/CR1/HSPA6	0.754952460441302
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/1650	41/9376	1.24736141906874	BABAM2/RBBP8/UIMC1/RAD51B/NBN/MRE11/BRCC3/TOP3B/SYCP3	0.733528495028555
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/1650	41/9376	1.24736141906874	MMP9/THBS1/RB1/DAPK3/DAPK2/RPS6KA5/EGFR/E2F3/CDKN2A	0.733528495028555
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	22/1650	110/9376	1.13648484848485	IGF1/SERPINE1/HIF1A/PIK3CA/PIK3R1/LTBR/STAT3/ARNT/IGF1R/RPS6KB2/TFRC/INSR/EGLN1/PFKP/MTOR/TEK/PRKCA/EPAS1/CAMK2G/EGFR/CDKN1B/PIK3CB	0.665403215174047
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1650	73/9376	1.16762141967621	MITF/PDGFRA/IGF1/PTEN/PDGFD/PIK3CA/PIK3R1/RB1/POLK/IGF1R/CDK6/EGFR/E2F3/CDKN2A/PIK3CB	0.664400105274378
NA	NA	hsa04981	Folate transport and metabolism	7/1650	31/9376	1.28312805474096	ABCC1/FPGS/DHFR/ABCC4/ABCC3/SLC19A1/ABCG2	0.72966641584206
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	11/1650	52/9376	1.20205128205128	IGF1/ADCY1/LDLR/PRKACB/ADCY3/IGF1R/ADCY9/PLA2G4C/INSR/HSD17B7/SCARB1	0.675168867182931
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/1650	26/9376	1.31132867132867	APOA1/ABCC1/LMBRD1/SCARB1/SLC19A1/TCN2	0.734598851723313
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1650	63/9376	1.17256373256373	WNT5A/WNT4/WNT6/TCF7L1/POLK/FZD3/WNT9A/APC/LEF1/GLI3/KIF7/CTNNB1/SUFU	0.635075352090709
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	22/1650	112/9376	1.11619047619048	HSPA1B/HLA-DRB1/HSPA1A/LAMA4/LAMB1/LAMA3/LDLR/STAT3/HLA-DMA/IRAK4/MAPK8/MAPK10/JAK2/MAP3K7/IKBKB/CASP3/IL10RB/CHUK/BIRC3/HSPA6/TGFB2/MAPK12	0.571650421632338
Cellular Processes	Cell motility	hsa04814	Motor proteins	37/1650	194/9376	1.08376132458607	TPM1/ACTA2/DNAH14/MYO9B/KIF13A/KIF26B/KIF18A/DCTN4/CAPZB/MYO6/HOOK3/KIF21A/MYL12A/ACTB/MYO9A/MYO1D/KIF16B/DYNC2H1/MYH10/STARD9/KIF7/KLC1/DNAH6/TPM2/MYO19/TUBA4A/MYO1F/MYO1E/KIF20B/KIF6/TUBA1A/KIF9/KIF5A/KIF27/MYO1G/KIF3B/DNAL1	0.544786096907181
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1650	37/9376	1.22863226863227	GALK2/UGP2/GMDS/FPGT/GFPT1/GNPNAT1/TGDS/UAP1	0.643929702824289
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/1650	37/9376	1.22863226863227	APOA1/LAMA4/GNAQ/PRKCA/FAS/IL18/SELE/FASLG	0.643929702824289
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	21/1650	107/9376	1.11524214103653	SIK2/ITPR1/FOXO1/PPP3CA/GNAQ/PRKAA1/ACACA/PRKACB/CREB1/PDE3B/PRKAG1/ACACB/PFKP/CALML4/CAMK2G/PYGL/CREB5/PHKA1/CREB3L2/ITPR3/PRKAA2	0.554034774440666
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1650	32/9376	1.2430303030303	BIRC6/MAPK8/MAPK10/CASP7/CASP3/BIRC3/PMAIP1	0.636384013228103
Human Diseases	Substance dependence	hsa05032	Morphine addiction	18/1650	91/9376	1.123996003996	ADCY1/PDE8A/GRK3/PDE4B/PDE4D/GRK5/PRKACB/PDE7A/GNB5/PDE3A/ADCY3/PDE3B/ADCY9/PRKCA/GNG12/OPRM1/PDE7B/GNG7	0.549272289896573
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	33/1650	173/9376	1.08393063583815	HLA-DRB1/CCL2/KPNA1/PABPN1/NUP98/PIK3CA/PIK3R1/IFNAR2/ADAR/KPNA6/HLA-DMA/IRAK4/RSAD2/NXT1/ACTB/MX1/PRKCA/DNAJB1/CDK6/XPO1/FAS/TICAM1/JAK2/IKBKB/OAS1/IL18/CASP3/IRF7/FASLG/CHUK/TNFSF10/PIK3CB/SLC25A4	0.514907374920142
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1650	75/9376	1.13648484848485	REV3L/PIK3CA/PIK3R1/MGST2/MSH3/FAS/CASP3/FASLG/POLH/CDKN2A/GSTO2/BIRC3/PMAIP1/PIK3CB/MAP3K5	0.548403868737264
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	32/1650	168/9376	1.08236652236652	PRL/PDGFRA/STAT4/IL2RB/SOS1/PRLR/GHR/PIAS1/PIK3CA/PIK3R1/SOCS2/IL13RA1/STAT5B/IFNAR2/CLCF1/STAT3/IL15/PIAS2/GRB2/IL2RG/MTOR/PTPN6/STAM2/JAK2/LEPR/EGFR/IL10RB/OSM/IL7/PIK3CB/IL20RB/FHL1	0.497820725946991
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1650	22/9376	1.29146005509642	MAOB/HNMT/MAOA/CARNMT1/ALDH7A1	0.632472953821719
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1650	17/9376	1.33704099821747	PCDH7/TFRC/MYH10/NRP2	0.642750950911704
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	20/1650	103/9376	1.10338334804354	ACTN1/LAMA4/VCL/ADCY1/GNAQ/ACTN4/PIK3CA/PIK3R1/LAMB1/LAMA3/PRKACB/PTK2/COL4A4/PRKCA/ARG1/CASP3/RAB5B/PIK3CB/ARG2/TGFB2	0.487538967709882
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/1650	76/9376	1.12153110047847	MYLK/ITPR1/ADCY1/GNAQ/EZR/PRKACB/ADCY3/ADCY9/ATP1B3/ACTB/ATP1A1/PRKCA/CALML4/CAMK2G/ITPR3	0.491589967124469
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	34/1650	181/9376	1.06741670852168	HLA-DRB1/CD74/FCER1G/HSPD1/C3/CTSD/CORO1A/PPP3CA/ARHGEF12/MALT1/CREB1/PIK3C3/HLA-DMA/IRAK4/MAPK8/MAPK10/ATP6V0A1/JAK2/CALML4/CAMK2G/MRC2/PLK3/IL18/CASP3/CR1/CAMP/RFXAP/IL10RB/RAB5B/CLEC7A/NFYA/ATP6V0A2/TGFB2/MAPK12	0.423234658085631
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/1650	44/9376	1.16231404958678	HLA-DRB1/GZMB/HSPD1/HLA-DMA/HLA-F/FAS/CPE/FASLG/CD86	0.498706862858206
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	22/1650	115/9376	1.08707246376812	KCNQ5/ITPR1/ADCY1/GNAQ/PIK3CA/PIK3R1/CACNA1C/PRKACB/GNB5/ADCY3/CREB1/ADCY9/PRKCA/JAK2/CACNA1D/CAMK2G/CREB5/GNG12/GNG7/CREB3L2/ITPR3/PIK3CB	0.434161260777098
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1650	28/9376	1.21766233766234	PPT1/THEM4/ELOVL5/MECR/HACD2/ACOT7	0.533031913012919
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1650	39/9376	1.16562548562549	AHCYL2/MTHFD2/DLD/MTHFD1L/DHFR/GART/MTHFD2L/ALDH7A1	0.478967501661435
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/1650	23/9376	1.23530961791831	MME/REN/ENPEP/PREP/NLN	0.522129688292308
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/1650	149/9376	1.06783811267033	CNR1/ITPR1/ADCY1/MT-ND4/GNAQ/CACNA1C/NDUFA4/PRKACB/MT-ND5/GNB5/ADCY3/NDUFS8/ADCY9/GRIA4/NDUFS2/MAPK8/MAPK10/NDUFA5/NDUFS4/PRKCA/NDUFA3/CACNA1D/GNG12/GNG7/ITPR3/NAPEPLD/ABHD6/MAPK12	0.385733083683741
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/1650	50/9376	1.13648484848485	HLA-DRB1/LTBR/IL15/HLA-DMA/ITGB7/MAP3K14/ITGA4/CD86/TNFSF13B/CCL28	0.447169317674796
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/1650	50/9376	1.13648484848485	KLRB1/CCL2/THBS1/KLRK1/ACKR1/ITGAL/IL18/CR1/SELE/TGFB2	0.447169317674796
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	20/1650	105/9376	1.08236652236652	TNFAIP3/CCL21/ERC1/TAB3/LTBR/MALT1/RELB/IRAK4/TRAF5/ZAP70/TICAM1/MAP3K14/MAP3K7/IKBKB/EDARADD/TRAF1/CHUK/BIRC3/TNFSF13B/TNFSF14	0.392222358848355
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	20/1650	105/9376	1.08236652236652	MITF/CCZ1B/HIF1A/USP15/HUWE1/SQSTM1/OPA1/MTX2/MAPK8/MAPK10/MAP1LC3A/SP1/RHOT1/SMURF1/PRKN/RAB5B/MON1B/ATG9A/ARIH1/ATG9B	0.392222358848355
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	16/1650	83/9376	1.09540708287696	POLR2K/POLR3GL/ADAR/GSDMD/CASP7/POLR3C/IKBKB/IL18/CASP3/ZBP1/IRF7/POLR3B/CHUK/POLR3A/ZDHHC1/POLR3E	0.403452074855984
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	38/1650	205/9376	1.05332742054693	MT-ATP6/MMP9/REN/CTSD/MT-CO2/PPP1CB/RAC2/MT-ND4/PTEN/PIK3CA/PIK3R1/NDUFA4/MT-ND5/RYR2/NDUFS8/TGFBR2/SMAD2/NDUFS2/MAPK8/INSR/PDK4/MAPK10/NDUFA5/NDUFS4/TGFBR1/MTOR/ATP5MC3/PRKCA/PDK3/NDUFA3/GFPT1/CAMK2G/SP1/PRKCD/PIK3CB/SLC25A4/TGFB2/MAPK12	0.356754466845143
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	19/1650	100/9376	1.07966060606061	MME/HLA-DRB1/ITGA1/CD7/CSF1R/CD55/CD37/HLA-DMA/TFRC/CD38/CD2/KITLG/CD3E/ITGA5/CR1/ITGA4/IL7/ITGA3/CD22	0.370095235912585
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	13/1650	67/9376	1.10255992763455	ITPR1/PPP3CA/ADCY1/PPP1CB/GNAQ/CACNA1C/PRKACB/PRKCA/GRIN2D/CALML4/CAMK2G/RAPGEF3/ITPR3	0.389326396741035
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1650	13/9376	1.31132867132867	XRCC4/MRE11/DCLRE1C	0.519079097723145
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/1650	62/9376	1.09982404692082	MAML3/ATXN1/ITCH/SPEN/NUMB/NOTCH2/LFNG/DTX3L/DTX3/PSENEN/PSEN2/TLE6	0.3644291925328
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	29/1650	157/9376	1.04961976452422	MT-CO2/ITCH/PRKAA1/PIK3CA/PIK3R1/NDUFA4/NDUFS8/PRKAG1/NDUFS2/MAPK8/INSR/MAPK10/NDUFA5/CASP7/NDUFS4/NDUFA3/FAS/GSK3A/IKBKB/LEPR/CASP3/SREBF1/FASLG/ADIPOR2/PIK3CB/PRKAA2/MAP3K5/PPARG/MAPK12	0.28974294901344
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/1650	57/9376	1.0966081871345	ACAT2/CBR4/ACACA/PPT1/ACSL4/ACADSB/ACADM/ELOVL5/ACSF3/MECR/HACD2	0.338078040826166
NA	NA	hsa04081	Hormone signaling	40/1650	219/9376	1.03788570637886	PRL/IGF1/ESR1/IGF2/SMAD9/ADCY1/AVPR1A/GNAQ/PRLR/PRKG2/GHR/RAMP3/PIK3CA/PIK3R1/STAT5B/PRKACB/STAT3/RAMP1/GNB5/PRKG1/ADCY3/IGF1R/ACVR1/ADCY9/PENK/BMPR1A/INSR/VIPR2/SMAD4/JAK2/NPR3/LEPR/GNG12/RAPGEF3/OPRM1/ADIPOR2/GNG7/SLC16A2/THRA/PIK3CB	0.262162818699396
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	54/1650	298/9376	1.02970103721782	PRL/CCL3/CCL2/IL1RL1/IL2RB/XCL1/CCL21/XCL2/TNFRSF18/TNFRSF4/CCL8/CXCL13/PRLR/ACKR3/BMPR2/CSF1R/GHR/ACVR1C/IL13RA1/NGF/LTBR/IFNAR2/CLCF1/CCL14/IL15/TGFBR2/ACVR1/ACVR2A/BMPR1A/CCL23/TGFBR1/IL2RG/IL17RA/RELL1/TNFRSF21/FAS/CXCR3/LEPR/IL18/FASLG/IL10RB/OSM/IL7/TNFSF13B/ACKR4/TNFSF10/TNFRSF8/IL20RB/GDF11/TNFSF14/TGFB2/IL16/CCL28/IL34	0.240788043113038
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/1650	52/9376	1.09277389277389	APOA1/NPC2/LDLR/OSBPL5/APOC2/NCEH1/SCARB1/APOC1/APOC3/ANGPTL4	0.310010624294886
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	17/1650	91/9376	1.06155178155178	PPP3CA/SOS1/VAV3/RAC2/PIK3CA/PIK3R1/NFATC3/MALT1/BANK1/GRB2/PTPN6/IKBKB/CHUK/PIK3CB/VAV2/CD22/NFKBIE	0.272659496359658
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1650	30/9376	1.13648484848485	SUCLG2/ACLY/DLD/OGDH/DLST/DLAT	0.346005051550278
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1650	47/9376	1.08812379110251	ACAT2/ACACA/DLD/ACACB/ME1/ME2/ACSS1/DLAT/ALDH7A1	0.279881899776764
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	66/1650	368/9376	1.01913043478261	GPX3/MT-ATP6/DNAH14/MT-CO2/PPP3CA/RANBP2/MT-ND4/MCU/NUP98/POM121/NUP214/DCTN4/NDUFA4/MT-ND5/SQSTM1/NUP160/ATXN2/NDUFS8/PIK3C3/SETX/NDUFS2/NCBP1/RAB1A/ALYREF/HSPA5/NDUFA5/NXT1/ALS2/ACTB/NDUFS4/MAP1LC3A/NUP210/MTOR/ATP5MC3/NDUFA3/ATXN2L/KLC1/SEH1L/NUP54/GRIN2D/DNAH6/NUP210L/ATG2B/NUP93/POM121C/CASP3/TUBA4A/PRKN/NUP155/ATG14/TUBA1A/KIF5A/ITPR3/SRSF7/HAP1/MAP3K5/NUP205/NRG2/ULK2/PIK3R4/DNAL1/NUP85/ANG/FIG4/NUP133/MAPK12	0.173015423228076
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/1650	59/9376	1.05943502824859	NUDT2/NME7/UPP1/ENTPD5/NT5C3A/CTPS2/CDA/CTPS1/DCK/CMPK2/ENPP1	0.2116316850739
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	23/1650	128/9376	1.02106060606061	FHIT/NUDT2/ADCY1/PDE8A/PDE4B/NME7/PDE4D/PDE7A/PDE3A/ADCY3/ENTPD5/PDE3B/ADCY9/AK4/AK3/ADA2/NUDT16/GART/PDE7B/GUCY1A1/DCK/PDE6D/ENPP1	0.110866974850356
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	17/1650	94/9376	1.0276724693746	CCL2/MMP9/TNFAIP3/TAB3/USP25/MAPK8/TRAF5/MAPK10/SRSF1/IL17RA/HSP90AA1/MAP3K7/TRAF4/IKBKB/CASP3/CHUK/MAPK12	0.124606678203515
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1650	60/9376	1.04177777777778	IGF1/PPP2CB/ITPR1/GNAQ/PRKG2/PRKG1/IGF1R/PLA2G4C/PRKCA/GUCY1A1/ITPR3	0.150022527914499
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1650	83/9376	1.02694414019715	SLC25A17/AGPS/PEX6/FAR1/ACSL4/PEX14/ABCD3/PEX3/PEX11B/NUDT12/NUDT19/MPV17L/CROT/PECR/FAR2	0.113939855825699
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	40/1650	226/9376	1.00573880396889	VAV3/ADCY1/PPP1CB/RAC2/PDE4B/PDE4D/PIK3CA/PIK3R1/PAK1/ATP2B4/CACNA1C/PRKACB/FXYD2/PDE3A/RYR2/ADCY3/CREB1/PDE3B/ADCY9/GRIA4/MAPK8/ROCK2/ATP1B3/VIPR2/MAPK10/PLD1/ATP1A1/GLI3/GRIN2D/ABCC4/CALML4/CACNA1D/CAMK2G/CREB5/RAPGEF3/AFDN/CREB3L2/PIK3CB/PTGER3/VAV2	0.0403566697553421
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/1650	38/9376	1.04676236044657	GALK2/UGP2/FPGT/GFPT1/GNPNAT1/GNPDA2/UAP1	0.13347857054841
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1650	38/9376	1.04676236044657	NAMPT/CD38/BST1/NUDT12/NNT/NADK2/ENPP1	0.13347857054841
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/1650	78/9376	1.0199222999223	C3/SERPING1/IRAK4/MAPK8/MAPK10/CASP7/CFL2/ITGA5/TICAM1/CALML4/NOD1/CASP3/C4A/MAPK12	0.0816473818118486
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1650	61/9376	1.02469945355191	ATP2B4/FXYD2/SLC8A1/ATP1B3/ATP1A1/TRPM7/MT1X/STEAP2/HMOX2/SLC39A4/MT1A	0.0894357372481158
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	8/1650	44/9376	1.03316804407713	HMGB1/POLB/RFC3/PARP4/POLG2/LIG1/POLE2/TDP1	0.101908191256157
Organismal Systems	Digestive system	hsa04976	Bile secretion	16/1650	90/9376	1.01020875420875	ADCY1/LDLR/PRKACB/FXYD2/ADCY3/ADCY9/ATP1B3/ATP1A1/ABCC4/NCEH1/SCARB1/SLC27A5/SLC10A1/ABCC3/UGT2B7/ABCG2	0.0449707283087927
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	36/1650	205/9376	0.997889135254989	HLA-DRB1/ISG15/B2M/TNFAIP3/NEDD4/MAP2K4/PIK3CA/PIK3R1/IFNAR2/RB1/STAT3/POLK/HLA-DMA/RELB/IRAK4/MAPK8/TRAF5/HLA-F/MAPK10/CD3E/CDK6/FAS/MAP2K7/MAP3K14/MAP3K7/ITGAL/IKBKB/OAS1/CASP3/IRF7/CDKN1B/E2F3/CHUK/PIK3CB/NFKBIE/MAPK12	-0.0141214485712072
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	18/1650	102/9376	1.0027807486631	KCNMA1/ITPR1/PLA2G2A/ADCY1/GNAQ/ATP2B4/FXYD2/RYR2/ADCY3/ADCY9/TRPC1/CD38/ATP1B3/ATP1A1/PRKCA/BST1/ITPR3/CPA1	0.0130490391948278
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1650	33/9376	1.03316804407713	BCKDHB/DLD/OGDH/DLST/DBT/DLAT	0.0882031135304316
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/1650	39/9376	1.0199222999223	HLA-DRB1/GZMB/HLA-DMA/HLA-F/FAS/FASLG/CD86	0.0576127169384463
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	19/1650	109/9376	0.990514317486795	CCL3/MAP2K4/PIK3CA/PIK3R1/IFNAR2/IRAK4/MAPK8/MAPK10/TICAM1/MAP2K7/MAP3K7/IKBKB/CTSK/IRF7/CHUK/CD86/MAP3K8/PIK3CB/MAPK12	-0.0460322825763795
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1650	28/9376	1.01471861471861	B4GALT1/B3GNT5/ST8SIA1/B3GNT2/B4GALT3	0.0360443218823374
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1650	70/9376	0.97412987012987	SOS1/HIF1A/PIK3CA/PIK3R1/PAK1/RAPGEF1/ARNT/EGLN1/GRB2/EPAS1/PIK3CB/TGFB2	-0.100395989211469
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	39/1650	227/9376	0.976275530636764	MT-ATP6/MT-CO2/SOS1/HIF1A/MT-ND4/PTEN/MAP2K4/PIK3CA/PIK3R1/ABL1/NDUFA4/MT-ND5/PRKD1/NDUFS8/ARNT/PTK2/MGST2/NDUFS2/MAPK8/PTPN1/MAPK10/NDUFA5/NDUFS4/PLD1/GRB2/ATP5MC3/NDUFA3/MAP2K7/PRKD2/MAP3K14/IKBKB/EGFR/GSTO2/CHUK/PRKCD/PIK3CB/MAP3K5/SLC25A4/MAPK12	-0.167214094234098
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1650	23/9376	0.988247694334651	ACAT2/PDSS2/PDSS1/ZMPSTE24	-0.0260772498296048
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1650	23/9376	0.988247694334651	GLUD1/FXYD2/ATP1B3/ATP1A1	-0.0260772498296048
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1650	17/9376	1.0027807486631	CYP7B1/CYP39A1/SLC27A5	0.00530300128740345
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1650	65/9376	0.961641025641026	ITPR1/GNAQ/PIK3CA/PIK3R1/CACNA1H/CACNA1C/TRPC1/PRKCA/CACNA1D/ITPR3/PIK3CB	-0.143408786171526
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/1650	95/9376	0.957039872408293	HLA-DRB1/CCL3/CCL2/ACP5/IL15/HLA-DMA/TEK/ATP6V0A1/ITGAL/ATP6V1C1/CTSK/IL18/CD86/TNFSF13B/ATP6V0A2/TGFB2	-0.194482369550237
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1650	42/9376	0.947070707070707	TFRC/ACSL4/CP/MAP1LC3A/ATG7/STEAP3/SAT1	-0.158868244907489
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1650	36/9376	0.947070707070707	GALNT17/ST6GALNAC3/GALNT13/B4GALT5/GALNT7/GALNT18	-0.147036163694579
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1650	36/9376	0.947070707070707	PRIM2/POLA1/RFC3/RNASEH2B/LIG1/POLE2	-0.147036163694579
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/1650	54/9376	0.947070707070707	AHCYL2/DNMT3A/MTAP/CISD1/DNMT1/SMS/MPST/MRI1/CDO1	-0.180255564959428
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1650	54/9376	0.947070707070707	REV3L/ATR/POLK/FANCL/FANCM/FANCC/REV1/POLH/TOP3B	-0.180255564959428
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1650	18/9376	0.947070707070707	HEXD/GLB1/AGA	-0.103870227520139
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/1650	73/9376	0.934097135740971	BST2/CPSF6/RANBP2/SERINC5/PDCD6IP/CCNT2/SMARCB1/MX1/XPO1/MLLT3/TRIM5/CDK9	-0.261218822965231
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1650	12/9376	0.947070707070707	NCAM1/NCAM2	-0.0847825102965016
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/1650	43/9376	0.925045806906272	APOA1/ACAT2/PLPP1/PLA2G2A/PLPP3/AGPAT1/SCARB1	-0.227651117475932
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/1650	85/9376	0.935928698752228	NME7/UPP1/ENTPD5/AK4/AK3/NT5C3A/CTPS2/CDA/ADA2/NUDT16/CTPS1/DCK/CMPK2/ENPP1	-0.274215522703139
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1650	37/9376	0.921474201474202	TCF7L1/POLK/CCDC6/LEF1/CTNNB1/PPARG	-0.221163418494028
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	19/1650	115/9376	0.938835309617918	MAOB/ITPR1/GNAQ/HTR2A/CACNA1C/PRKACB/GNB5/KCND2/TRPC1/PLA2G4C/MAOA/PRKCA/SLC18A2/CACNA1D/CASP3/GNG12/RAPGEF3/GNG7/ITPR3	-0.304979759870415
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1650	19/9376	0.897224880382775	HGSNAT/GLB1/SGSH	-0.207227188593356
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/1650	38/9376	0.897224880382775	PTPRC/ZAP70/IL2RG/CD3E/DCLRE1C/RFXAP	-0.293361496798757
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	81/1650	480/9376	0.958909090909091	WNT5A/SNCAIP/GPX3/MT-ATP6/DNAH14/WNT4/MT-CO2/ATXN1/ITPR1/PPP3CA/MT-ND4/GNAQ/MCU/UBE2G2/LRP6/HIP1/DCTN4/DKK1/CACNA1C/WNT6/NDUFA4/MT-ND5/SQSTM1/ATXN2/RYR2/LRP5/NDUFS8/PIK3C3/GRIA4/NDUFS2/MAPK8/RAB1A/MAPK10/HSPA5/HTT/NDUFA5/ALS2/CASP7/NDUFS4/MAP1LC3A/FZD3/WNT9A/MTOR/APC/ATP5MC3/PRKCA/NDUFA3/ATXN2L/KLC1/FAS/UBE2G1/MAP2K7/GRIN2D/LRRK2/DNAH6/CALML4/CACNA1D/CAMK2G/ATG2B/CSNK1E/CASP3/CTNNB1/TUBA4A/PRKN/CDK5/FASLG/ATG14/TUBA1A/SNCA/KIF5A/ITPR3/HAP1/MAP3K5/PSEN2/SLC25A4/ULK2/PIK3R4/DNAL1/FIG4/MAP3K10/MAPK12	-0.427089839474102
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1650	32/9376	0.887878787878788	B4GALT1/UGP2/GALM/PFKP/GLB1	-0.293593622062841
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	65/1650	388/9376	0.951952514839113	MME/WNT5A/MT-ATP6/WNT4/MT-CO2/ITPR1/PPP3CA/MT-ND4/GNAQ/MCU/LRP6/ADAM10/PIK3CA/PIK3R1/DKK1/CACNA1C/WNT6/NDUFA4/MT-ND5/BACE2/LRP5/NDUFS8/PIK3C3/NDUFS2/MAPK8/INSR/IDE/MAPK10/NDUFA5/CASP7/NDUFS4/SLC39A11/FZD3/WNT9A/MTOR/APC/ATP5MC3/NDUFA3/KLC1/FAS/MAP2K7/GRIN2D/CALML4/CACNA1D/ATG2B/CSNK1E/IKBKB/CASP3/CTNNB1/TUBA4A/CDK5/ATG14/CHUK/SLC39A4/TUBA1A/SNCA/KIF5A/ITPR3/PIK3CB/PSENEN/MAP3K5/PSEN2/SLC25A4/ULK2/PIK3R4	-0.44668899261599
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/1650	88/9376	0.904022038567493	CFH/SERPINE1/MASP1/C3/SERPING1/F3/F2RL2/TFPI/CD55/C7/PLAUR/CFI/CR1/C4A	-0.418024765971529
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1650	76/9376	0.897224880382775	SORBS1/APOA1/FABP5/ACSL4/ME1/FABP4/PLIN1/SLC27A5/ACADM/APOC3/PPARG/ANGPTL4	-0.415722539127307
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/1650	155/9376	0.916520039100684	HLA-DRB1/C3/STX12/CORO1A/THBS1/PIKFYVE/PIK3C3/HLA-DMA/STX7/TFRC/HLA-F/ACTB/SEC61G/DYNC2H1/ATP6V0A1/ITGA5/MRC2/ATP6V1C1/SEC61A2/TUBA4A/SCARB1/RAB5B/TUBA1A/CLEC7A/ATP6V0A2	-0.484294273118273
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1650	89/9376	0.893864487572353	PLCL1/SLC38A1/ADCY1/CACNA1C/PRKACB/GNB5/ADCY3/GPHN/ADCY9/PRKCA/CACNA1D/GNG12/GNG7/HAP1	-0.464909327983818
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1650	27/9376	0.841840628507295	ACAT2/OXCT1/BDH1/ACSM6	-0.380315907505937
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	27/1650	168/9376	0.913246753246753	STAT4/TNFAIP3/HMGB1/STAT5B/IFNAR2/STAT3/GLUD1/SQSTM1/PLA2G4C/MAPK8/TRAF5/MAPK10/TRPM7/FAS/TICAM1/HSP90AA1/JAK2/CAMK2G/PYGL/ZBP1/FASLG/SPATA2L/BIRC3/RNF31/CHMP1B/TNFSF10/SLC25A4	-0.524333953117258
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	45/1650	275/9376	0.929851239669422	HSPA1B/HSPA1A/MT-ATP6/NCAM1/MT-CO2/ITPR1/PPP3CA/RAC2/MT-ND4/MCU/PIK3CA/PIK3R1/NCAM2/CACNA1C/NDUFA4/PRKACB/C7/MT-ND5/RYR2/NDUFS8/CREB1/NDUFS2/MAPK8/MAPK10/HSPA5/NDUFA5/NDUFS4/ATF6B/ATP5MC3/NDUFA3/KLC1/GRIN2D/CACNA1D/CREB5/CASP3/TUBA4A/CREB3L2/TUBA1A/KIF5A/ITPR3/PRKCD/PIK3CB/HSPA6/SLC25A4/MAPK12	-0.545622220539489
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/1650	78/9376	0.874219114219114	HLA-DRB1/C3/HLA-DMA/IRAK4/PTPN6/JAK2/MARCKSL1/MAP3K7/CR1/ITGA4/TGFB2/MAPK12	-0.515486668007099
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1650	21/9376	0.811774891774892	CHST11/CHSY3/CSGALNACT1	-0.399039203909132
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/1650	66/9376	0.860973370064279	HLA-DRB1/STAT4/RORA/STAT3/HLA-DMA/SMAD2/MAF/IL2RG/IL18/TGFB2	-0.523775742393769
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1650	103/9376	0.882706678434834	MME/FXYD2/COL4A4/SLC8A1/COL19A1/SLC7A8/SLC1A1/ATP1B3/ATP1A1/ELN/COL5A2/COL27A1/COL24A1/COL26A1/COL25A1/CPA1	-0.553136128760886
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1650	60/9376	0.852363636363636	PPP3CA/RAC2/PIK3CA/PIK3R1/PTK2/PLA2G4C/PRKCA/PIK3CB/MAPK12	-0.530156979690117
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1650	79/9376	0.863153049482163	SYT1/AP2B1/DNM2/SLC1A1/UNC13B/ATP6V0A1/SLC18A2/STXBP1/ATP6V1C1/DNM3/VAMP2/ATP6V0A2	-0.564452645243647
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	18/1650	116/9376	0.881755485893417	ACAT2/HIBCH/SUCLG2/GLUD1/PCCA/DLD/PFKP/ME1/ALDH6A1/OGDH/H6PD/RGN/ME2/ACSS1/DLST/ADPGK/DLAT/ENO4	-0.59218139768036
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1650	48/9376	0.828686868686869	PIK3CA/PIK3R1/FXYD2/ATP1B3/ATP1A1/CACNA1D/PIK3CB	-0.549879161444856
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1650	15/9376	0.757656565656566	AK4/TPK1	-0.434076248914917
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1650	42/9376	0.811774891774892	ACAT2/MAOB/DLD/MAOA/DLST/ALDH7A1	-0.564961119567418
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	24/1650	154/9376	0.885572609208973	NME7/UGP2/MTHFD2/GPHN/AK4/AK3/PTS/DLD/MTHFD1L/MMAB/MOCS2/CTPS2/FPGS/COX10/DHFR/RGN/CTPS1/NADK2/UGT2B7/COQ2/PNPO/MTHFD2L/TPK1/CMPK2	-0.661649601115382
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/1650	87/9376	0.849097875304772	TPM1/CACNB2/MT-CO2/CACNA2D1/CACNA1C/FXYD2/RYR2/SLC8A1/ATP1B3/ATP1A1/CACNA1D/TPM2/CACNA2D3	-0.653462632403564
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1650	23/9376	0.741185770750988	GLUD1/ARG1/ARG2	-0.574284187951517
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1650	23/9376	0.741185770750988	MSH3/RFC3/LIG1	-0.574284187951517
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1650	16/9376	0.71030303030303	MAOB/MAOA	-0.535940130613971
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	49/1650	308/9376	0.904022038567493	GPX3/MT-ATP6/DNAH14/MT-CO2/ITPR1/MT-ND4/GNAQ/POLR2K/HIP1/POLR2A/DCTN4/NDUFA4/MT-ND5/NDUFS8/CREB1/AP2B1/PIK3C3/GRIA4/POLR2J3/NDUFS2/MAPK8/MAPK10/HTT/NDUFA5/NDUFS4/MTOR/ATP5MC3/NDUFA3/KLC1/MAP2K7/DNAH6/ATG2B/CREB5/SP1/CASP3/TUBA4A/ATG14/CREB3L2/TUBA1A/KIF5A/HAP1/TAF4/MAP3K5/SLC25A4/ULK2/PPARG/PIK3R4/DNAL1/MAP3K10	-0.791482619093914
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	40/1650	254/9376	0.894869959436889	PDGFRA/MYLK/ITPR1/PPP3CA/ADCY1/AVPR1A/GNAQ/MCU/PDGFD/HTR2A/CACNA1H/NGF/ATP2B4/CACNA1C/NFATC3/PRKACB/ITPKB/RYR2/ADCY3/ORAI2/STIM2/ADCY9/STIM1/SLC8A1/PTK2B/CD38/TPCN1/PRKCA/GRIN2D/CALML4/CACNA1D/CAMK2G/VEGFC/PHKA1/EGFR/P2RX4/ITPR3/PTGER3/SLC25A4/ITPKC	-0.784962509114627
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/1650	89/9376	0.830017024174328	FREM1/LAMA4/ITGA1/THBS1/ITGA9/LAMB1/LAMA3/COL4A4/ITGA5/ITGB7/ITGA4/RELN/ITGA3	-0.744582743817019
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1650	31/9376	0.733216031280547	RBKS/PFKP/H6PD/RGN	-0.687545084282609
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1650	31/9376	0.733216031280547	HIBCH/ALDH6A1/SMOX/ALDH7A1	-0.687545084282609
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1650	31/9376	0.733216031280547	ACAT2/PCCA/DLD/ACSS1	-0.687545084282609
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1650	17/9376	0.668520499108734	CA5B/GLUD1	-0.632144948336897
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1650	46/9376	0.741185770750988	MMAB/CP/COX10/HMOX2/UGT2B7/FXN	-0.8131609263378
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	33/1650	217/9376	0.864147465437788	KPNA1/ESR1/SOS1/ADCY1/PIK3CA/PIK3R1/STAT5B/CACNA1C/RB1/PRKACB/STAT3/KPNA6/ADCY3/CREB1/ARNT/PGR/ADCY9/RPS6KB2/MGST2/NOTCH2/GRB2/ATF6B/MTOR/PRKCA/HSP90AA1/JAK2/CACNA1D/CREB5/EGFR/GSTO2/CREB3L2/UGT2B7/PIK3CB	-0.935672447599301
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1650	10/9376	0.568242424242424	MPST	-0.631267089300165
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/1650	54/9376	0.736610549943883	HLA-DRB1/GZMB/HLA-DMA/HLA-F/FAS/FASLG/CD86	-0.896996946240001
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1650	27/9376	0.631380471380471	ELOVL5/HACD2/ACOT7	-0.88639622950078
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/1650	35/9376	0.649419913419913	GMDS/FPGT/PFKP/ENOSF1	-0.960229045261906
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1650	28/9376	0.608831168831169	ATP6V0A1/ATP6V1C1/ATP6V0A2	-0.957930860378827
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/1650	43/9376	0.660747004933051	ACAT2/ACSL4/ACADSB/ACADM/ALDH7A1	-1.03038029290066
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/1650	71/9376	0.720307298335467	PDGFRA/HIF1A/PTEN/PIK3CA/PIK3R1/PFKP/MTOR/EGFR/PIK3CB	-1.09320693485479
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1650	36/9376	0.631380471380471	UGP2/CRPPA/XYLB/UGT2B7	-1.02401521636658
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1650	12/9376	0.473535353535353	COQ2	-0.843294739819401
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/1650	72/9376	0.71030303030303	ISG15/ADAR/MAPK8/MAPK10/MAP3K7/IKBKB/IRF7/CHUK/MAPK12	-1.1403170243248
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/1650	67/9376	0.67849841700588	DLD/GALM/PFKP/ACSS1/ADPGK/DLAT/ENO4/ALDH7A1	-1.22044794434379
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	39/1650	268/9376	0.826919945725916	SNCAIP/MAOB/MT-ATP6/MT-CO2/ITPR1/MT-ND4/MCU/UBE2G2/NDUFA4/PRKACB/MT-ND5/NDUFS8/NDUFS2/MAPK8/MAOA/MAPK10/HSPA5/NDUFA5/NDUFS4/SLC39A11/ATP5MC3/NDUFA3/SLC18A2/KLC1/UBE2G1/LRRK2/CALML4/CAMK2G/CASP3/TUBA4A/PRKN/SLC39A4/TUBA1A/SNCA/KIF5A/ITPR3/MAP3K5/SLC25A4/TH	-1.32847433050856
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1650	31/9376	0.549912023460411	RGN/UGT2B7/ALDH7A1	-1.1599489176575
Human Diseases	Immune disease	hsa05310	Asthma	3/1650	32/9376	0.532727272727273	HLA-DRB1/FCER1G/HLA-DMA	-1.22357125735378
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1650	41/9376	0.554382852919438	MAOB/DLD/MAOA/ALDH7A1	-1.32143838957397
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1650	16/9376	0.355151515151515	ST8SIA1	-1.19297133676415
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1650	26/9376	0.437109557109557	PLA2G2A/PLA2G4C	-1.32817408441259
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1650	17/9376	0.334260249554367	CDO1	-1.2695928979612
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1650	17/9376	0.334260249554367	TXNRD3	-1.2695928979612
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1650	36/9376	0.473535353535353	UGP2/PYGL/ENPP1	-1.46250474270257
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1650	37/9376	0.460737100737101	RIMKLB/GLUD1/GFPT1	-1.5188031004715
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1650	37/9376	0.460737100737101	MAOB/MAOA/TH	-1.5188031004715
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/1650	99/9376	0.631380471380471	CFH/HLA-DRB1/MASP1/C3/KRT23/HLA-DMA/CFI/ITGAL/CAMP/KRT18/C4A	-1.70389338483389
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1650	29/9376	0.391891327063741	CALML4/GUCA1B	-1.51563397996222
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1650	30/9376	0.378828282828283	PLA2G2A/PLA2G4C	-1.57474294331971
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	31/1650	238/9376	0.740147695441813	ISG15/RPL36AL/CCL2/MASP1/C3/RPS10/RPL35/RPS12/RPS24/PIK3CA/PIK3R1/NRP1/IFNAR2/ADAR/STAT3/C7/RPL36A/IRAK4/MAPK8/RSL24D1/MAPK10/MX1/PRKCA/MAP3K7/IKBKB/OAS1/EGFR/CHUK/PIK3CB/C4A/MAPK12	-1.87646182237594
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	44/1650	323/9376	0.774076367389061	PDGFRA/TPM1/MMP9/HDAC4/SOS1/THBS1/PTEN/BMPR2/EZR/DICER1/PIK3CA/PIK3R1/EFNA5/ABL1/ABCC1/MDM4/FOXP1/DNMT3A/STAT3/STMN1/PRKCE/NOTCH2/ZFPM2/HOXD10/ZEB1/FZD3/GRB2/MTOR/APC/PRKCA/CDK6/ITGA5/DNMT1/SPRY2/IKBKB/RPS6KA5/FSCN1/CASP3/EGFR/CDKN1B/E2F3/CDKN2A/PIK3CB/TGFB2	-1.9094879488563
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1650	21/9376	0.270591630591631	ENPP1	-1.54635339460279
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	24/1650	195/9376	0.699375291375291	HDAC4/C3/RAC2/HDAC8/HAT1/HMGB1/PIK3CA/PIK3R1/CLCN3/GSDMD/ACTB/MTOR/ATG7/PRKCA/MAP3K7/ITGAL/CR1/CAMP/CLCN5/CLEC7A/PIK3CB/SLC25A4/ELANE/MAPK12	-1.96041150769147
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/1650	59/9376	0.481561376476631	GPX3/MGST2/SMS/GSTO2/LANCL1	-1.84601644412024
NA	NA	hsa04382	Cornified envelope formation	27/1650	217/9376	0.707029744449099	CLDN10/PPP2CB/KRT81/KAZN/KRT23/DSG2/OCLN/S100A1/LAMA3/SPTLC3/PKP2/KRT86/CLDN5/CLDN4/CLDN3/SPTLC1/COL4A4/PPP2R3A/PPP2R5E/PPP2R2D/TJP1/CLDN12/UGCG/DSG3/KRT18/PPP2R2B/CLDN20	-2.01780700646091
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/1650	138/9376	0.617654808959157	MT-ATP6/MT-CO2/MT-ND4/NDUFA4/MT-ND5/NDUFS8/NDUFS2/NDUFA5/NDUFS4/ATP5MC3/NDUFA3/COX10/ATP6V0A1/ATP6V1C1/ATP6V0A2	-2.09101166142408
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1650	63/9376	0.450986050986051	PLA2G2A/TBXAS1/PLA2G4C/LTC4S/PTGIS	-2.02050118986602
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/1650	73/9376	0.467048567870486	MAOB/MGST2/MAOA/CYP3A5/GSTO2/UGT2B7	-2.11245667944445
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/1650	82/9376	0.485084996304509	NME7/UPP1/CES1/MGST2/CDA/GSTO2/UGT2B7	-2.16417012256076
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/1650	75/9376	0.454593939393939	PFKP/ARG1/PYCR2/ALDH18A1/ENO4/ARG2	-2.1914725113412
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1650	68/9376	0.417825311942959	ALDH1A2/ALDH1A3/CYP3A5/CYP27C1/UGT2B7	-2.22653664151035
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/1650	191/9376	0.624769157544027	MAOB/HDAC4/SOS1/PPP1CB/HDAC8/HAT1/PRKACB/GNB5/CREB1/MAOA/GRB2/ATF6B/SLC18A2/GRIN2D/CALML4/CREB5/GNG12/GNG7/CREB3L2/SLC29A1/TH	-2.4211733788008
NA	NA	hsa04082	Neuroactive ligand signaling	22/1650	199/9376	0.62820770519263	GRM7/ADCY1/GNAQ/HTR2A/P2RY1/PRKACB/GNB5/ADCY3/GRIK1/ADCY9/GRIA4/PENK/SLC1A1/PRKCA/SLC18A2/GRIN2D/P2RY14/GNG12/OPRM1/GNG7/P2RX4/GRIK2	-2.4497784827659
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1650	41/9376	0.277191426459719	GRIA4/GRIN2D	-2.14342514341498
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1650	70/9376	0.405887445887446	MGST2/SULT1A1/CYP3A5/GSTO2/UGT2B7	-2.30561338008401
Genetic Information Processing	Transcription	hsa03040	Spliceosome	28/1650	243/9376	0.654764933283452	HSPA1B/HSPA1A/SF1/HNRNPU/TRA2A/TRA2B/DDX46/LSM5/BCAS2/SNRPD1/RBM8A/NCBP1/ALYREF/SRSF1/MAGOH/RP9/SNRPA1/PRPF38A/AQR/U2AF2/PRPF19/LSM6/SF3A2/PRPF3/SRSF7/PRPF18/HSPA6/THOC3	-2.51977387262892
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1650	66/9376	0.344389348025712	CYP7B1/HSD17B7/CYP3A5/UGT2B7	-2.46997971624475
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/1650	46/9376	0.247061923583663	PSME2/PSMF1	-2.3656343218465
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	17/1650	183/9376	0.527875476072197	MDN1/NOP58/XRN1/WDR75/NVL/RBM28/FBLL1/NXT1/LSG1/NMD3/HEATR1/XPO1/DROSHA/REXO1/GNL2/DKC1/EFL1	-2.98060024708956
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/1650	79/9376	0.287717683160721	MGST2/CYP3A5/GSTO2/UGT2B7	-2.93795102031011
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1650	86/9376	0.264298801973221	CACNA1C/P2RY1/PRKACB/ITPR3	-3.16732836617302
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/1650	143/9376	0.397372324645052	HLA-DRB1/ACTN1/C3/ACTN4/C7/HLA-DMA/SNRPD1/CD86/C4A/ELANE	-3.35579893506916
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	35/1650	370/9376	0.537526617526618	PRL/GRM7/CNR1/C3/GAL/LPAR1/CALCRL/AVPR1A/PRLR/GHR/HTR2A/F2RL2/TMEM97/P2RY1/LPAR6/GRIK1/GRIA4/NR3C1/PENK/VIPR2/RXFP1/GRIN2D/PTGER4/P2RY14/LEPR/PTGDR/LYNX1/OPRM1/P2RX4/GRIK2/THRA/PTGER3/S1PR4/UTS2/S1PR2	-4.19441976519601
Genetic Information Processing	Translation	hsa03010	Ribosome	16/1650	222/9376	0.40954408954409	RPL36AL/RPS10/RPL35/RPS12/RPS24/MRPS18B/MRPL42/MRPL33/RPL36A/RSL24D1/MRPS27/MRPS28/MRPL12/MRPL52/MRPL1/MRPL28	-4.11442135875507
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	12/1650	449/9376	0.151868799352096	NCALD/GRK3/PRKG2/PRKACB/RGS2/PRKG1/ADCY3/SLC8A1/CALML4/CAMK2G/GNG7/OR3A2	-8.5110609698521