category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	71/1655	158/9376	2.5457799533443	CDKN2A/CCND3/CUL1/NIPBL/CDKN1C/PPP2R5A/PDS5A/ATRX/CCNH/PDS5B/TFDP1/CDK6/ATR/CDC27/PPP2R5E/STAG1/GSK3B/ESCO1/EP300/RBX1/SMAD4/BUB3/SMC1A/ANAPC5/PCNA/TFDP2/HDAC8/RBL1/ANAPC10/YWHAZ/WEE1/BUB1/MCM3/YWHAH/MCM6/KNL1/HDAC2/E2F3/RB1/ORC4/FZR1/ORC3/DBF4/MAD2L1/CDKN1B/MTBP/ANAPC4/ORC6/ORC2/ANAPC15/MCM5/PTTG1/E2F5/CDC6/ORC5/DBF4B/CDK2/SGO1/MCM7/CDCA5/AURKB/CDC20/CDK1/CCNB1/BUB1B/CDC14A/CDC23/CHEK1/MCM2/ORC1/CCNA2	9.07205602157159
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	60/1655	142/9376	2.39377047785201	BIRC6/HERC1/ITCH/CUL1/PIAS1/UBA6/FBXW8/COP1/UBE2W/MAP3K1/CDC27/UBE2J1/HERC3/UBE3C/FBXW7/UBE2K/UBE2H/CBL/HUWE1/SMURF2/RBX1/UBE2G1/WWP1/UBE2N/UBE4A/UBE3A/UBE2O/ANAPC5/TRIP12/UBR5/HERC4/ANAPC10/UBA3/FANCL/SOCS1/WWP2/BTRC/CUL3/UBE2E3/PML/UBE2D2/CUL2/DDB2/FBXW11/SMURF1/TRAF6/FZR1/CBLB/ANAPC4/RCHY1/UBE2C/PPIL2/TRIM37/ANAPC15/FBXO4/PIAS2/CDC20/BRCA1/CDC23/SYVN1	7.74797765201476
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	55/1655	138/9376	2.25789220193529	VAV3/RPS6KA3/FYB1/LCP2/ARPC5L/SKAP2/ACTB/ZAP70/RAC2/WIPF3/ARF6/ACTR2/GNAQ/WAS/NFKB1/PIK3R1/ARHGEF7/WIPF1/MAP2K4/ARHGEF1/ACTR3/NFATC3/PTK2B/GSK3B/MAPK14/PIK3CB/LIMK1/PKN2/GIT2/IRAK4/MAPK8/ROCK1/ARPC4/ELMO1/MAPK1/ARPC1B/ITGB1/ARPC2/ITGA4/TBK1/IL18/MAP3K7/PYCARD/TAB2/IKBKB/MAP2K1/ARPC3/LAT/TRAF6/ARHGEF12/CASP1/RPS6KA1/ARHGEF28/ACTR3C/MAP2K6	6.89194574748693
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	21/1655	36/9376	3.30473313192346	PRIM2/RNASEH2B/RNASEH2C/PCNA/RPA1/POLA1/MCM3/MCM6/RFC2/POLE4/LIG1/DNA2/RFC3/MCM5/POLE/PRIM1/MCM7/FEN1/POLD3/POLD1/MCM2	6.41425643270618
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	50/1655	138/9376	2.05262927448662	RPS6KA3/PRKACB/PPP3CA/CUL1/PPP2R5A/CAMK2G/CAMK2D/CDC27/PPP2R5E/SPDYE2/PPP3CC/MAPK14/ADCY7/SPDYA/RBX1/SLK/MAPK1/PPP3R1/CALM3/ADCY9/PPP1CA/ITPR1/SMC1A/ANAPC5/ANAPC10/YWHAZ/BUB1/BTRC/YWHAH/CPEB3/MAP2K1/ITPR2/FBXW11/ITPR3/MAD2L1/PPP1CB/REC8/RPS6KA1/ANAPC4/ANAPC15/CPEB2/PTTG1/CDK2/SGO1/CDC20/CDK1/SPDYE5/CCNB1/CDC23/AURKA	5.76731761339877
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	54/1655	157/9376	1.94855966286297	PPP3CA/CDKN2A/CCND3/RRAS2/SERPINE1/KIR2DL4/HIPK1/KRAS/NFKB1/PIK3R1/CDK6/ATR/NFATC3/PPP3CC/MAPK14/HIPK2/IGFBP3/PIK3CB/ZFP36L2/MAPK1/PPP3R1/CALM3/MRE11/PPP1CA/ITPR1/TGFBR1/ETS1/HLA-A/RBL1/BTRC/VDAC3/HIPK3/FOXO3/MAP2K1/MTOR/E2F3/ITPR2/RB1/FBXW11/LIN52/ITPR3/PPP1CB/PPID/MCU/HLA-C/LIN54/E2F5/CDK2/CDK1/CCNB1/MAP2K6/CHEK1/CCNA2/MYBL2	5.54907292460129
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	76/1655	250/9376	1.72223806646526	VPS37B/RAB11FIP1/LDLR/SMAP2/ARPC5L/ARAP2/ITCH/PLD1/EPS15/STAM/WIPF3/ARF6/ACTR2/ACAP2/PDCD6IP/WIPF1/CYTH1/IL2RB/ARFGAP3/ACTR3/CAPZA1/ARFGEF1/SMAP1/CYTH4/RABEP1/CBL/GIT2/SMURF2/ARPC4/WWP1/ARPC1B/IL2RG/CHMP5/TGFBR1/GRK2/ARPC2/ACAP1/VTA1/ASAP1/VPS36/VPS45/HLA-A/WASHC4/AP2B1/SNX3/WASHC1/RAB10/GBF1/VPS26A/USP8/PML/VPS37A/AGAP3/IGF2R/ZFYVE16/STAM2/SNX5/ARAP1/ARPC3/SMURF1/SNX4/TRAF6/SNX1/CYTH2/RAB8A/AGAP2/RAB11FIP3/CBLB/EPS15L1/TSG101/WASHC2C/HLA-C/ZFYVE27/RAB5B/ACTR3C/RBSN	5.35868227619861
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	76/1655	253/9376	1.70181627121073	SEPTIN7/BCL2/ARPC5L/PFN1/ACTB/CUL1/PLCG2/HCLS1/ARF6/ACTR2/ACTN4/SEPTIN6/NFKB1/PIK3R1/MALT1/CYTH1/PLCB1/ACTR3/CAST/RPS6KA5/GLMN/CYTH4/GSK3B/MAPK14/DIAPH1/PIK3CB/BAX/MYL12A/MAPK8/ROCK1/ARPC4/ELMO1/RBX1/MAPK1/TLN1/UBE2N/ARPC1B/ITGB1/ITPR1/ARPC2/HKDC1/TBK1/TRAF5/ATG16L1/IL18/MAP3K7/PYCARD/BTRC/TAB2/RPTOR/IKBKB/UBE2D2/UBE2V1/TIFA/FOXO3/BCL2L1/MTOR/ARPC3/ITPR2/FBXW11/RPS6KB2/PLCB2/TRAF6/CYTH2/BCL10/RNF31/U2AF1/CASP1/ITPR3/SEPTIN11/PPID/NOD1/FNBP1L/U2AF1L4/TLN2/ACTR3C	5.23917273163957
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	46/1655	133/9376	1.95941212547986	KLRC3/KLRC1/KLRC2/TYROBP/KLRK1/HCST/VAV3/PPP3CA/LCP2/LAT2/SOS1/CASP3/BRAF/KLRD1/ZAP70/SYK/PLCG2/RAC2/FCER1G/KIR2DL4/KRAS/PRF1/PIK3R1/FYN/ITGAL/SOS2/PTK2B/CD247/GZMB/PPP3CC/PIK3CB/SH2D1B/TNFRSF10A/NCR1/PTPN6/MAPK1/PPP3R1/IFNAR2/HLA-A/TNFSF10/MAP2K1/LAT/HLA-C/KIR3DL1/SH3BP2/PAK1	5.15908172952401
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	43/1655	122/9376	1.9967708384924	PTPRC/VAV3/PPP3CA/LCP2/ITK/SOS1/PPP2R2B/ZAP70/DLG1/MAP3K8/PPP2R5A/KRAS/NFKB1/PIK3R1/FYN/MALT1/NFATC3/PPP2R5E/SOS2/CD247/GSK3B/PPP3CC/MAPK14/PIK3CB/PPP2R2A/NCK1/PTPN6/MAPK8/MAPK1/PPP3R1/PAK2/CARD11/MAP3K7/TEC1/RASGRP1/IKBKB/PPP2R3C/MAP2K1/LAT/BCL10/CBLB/PAK1/NFKBIE	5.13048417747324
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	65/1655	214/9376	1.72075556935935	BST2/PPP3CA/BCL2/CASP3/CUL1/PLCG2/RAC2/SAMHD1/GNAQ/KRAS/NFKB1/PIK3R1/ATR/CASP8/NFATC3/AP1S2/PTK2B/CD247/TAPBP/APOBEC3D/PPP3CC/MAPK14/PIK3CB/LIMK1/BAX/IRAK4/GNAI2/MAPK8/RBX1/MAPK1/PPP3R1/CALM3/CFL1/ITPR1/PAK2/AP1S3/TNFRSF1B/TBK1/HLA-A/TRAF5/WEE1/MAP3K7/BTRC/TAB2/IKBKB/MAP2K1/BCL2L1/MTOR/ITPR2/FBXW11/RPS6KB2/TRAF6/ITPR3/GNB1/TAP2/APOBEC3H/CASP9/HLA-C/CDK1/CCNB1/MAP2K6/PAK1/GNGT2/BAK1/CHEK1	4.93796049227565
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	39/1655	108/9376	2.045787176905	KPNA1/IPO11/RANBP2/NUP210/UPF2/XPO6/POM121/THOC2/KPNA3/NUP214/NUP50/KPNB1/ACIN1/NUP160/NUP42/NUP54/XPO1/RANBP17/DDX19B/IPO7/NUP107/NUP155/NUP133/NUP43/PNN/UPF3A/ALYREF/NUP205/UPF3B/MAGOH/PYM1/KPNA6/POM121C/NCBP1/KPNA5/CSE1L/DDX19A/NUP37/GLE1	5.06069353993677
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	67/1655	224/9376	1.69451877427708	PRKACB/PPP3CA/KAT2B/CDKN2A/CCND3/DLG1/KRAS/NFKB1/PIK3R1/ATR/IL2RB/MAP2K4/MAP3K1/NFATC3/CDC27/ITGAL/PPP3CC/ETS2/PIK3CB/BAX/EP300/ADCY7/TSPO/MAPK8/MAPK1/PPP3R1/ADCY9/TLN1/IL2RG/TGFBR1/SMAD4/ETS1/BUB3/ANAPC5/CREB1/HLA-A/RANBP1/ANAPC10/IL1R2/XPO1/VDAC3/ATF6B/CRTC3/IKBKB/ELK4/TBPL1/POLB/MAP2K1/BCL2L1/E2F3/RB1/ZFP36/MAD2L1/ANAPC4/JAK3/NFYB/TBP/ANAPC15/HLA-C/PTTG1/CDK2/CDC20/TLN2/BUB1B/CDC23/CHEK1/CCNA2	4.87077260319454
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	20/1655	41/9376	2.76353990126004	RAD51B/BABAM2/RBBP8/TOPBP1/MRE11/BARD1/RPA1/UIMC1/BLM/BRIP1/BRCC3/BRCA2/SYCP3/RAD51D/RAD51C/XRCC3/BRCA1/POLD3/RAD54B/POLD1	5.23923548116796
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	36/1655	98/9376	2.0811147419693	PIP4K2A/PLCG2/SACM1L/PIK3R1/DGKE/INPP4A/PI4KA/PLCB1/PIKFYVE/PIK3C2A/INPP5B/DGKD/DGKZ/PIK3CB/PPIP5K2/CALM3/MTMR1/ITPR1/MTMR3/IMPA1/MTM1/PI4K2B/INPP5A/ITPR2/SYNJ1/PLCB2/IPPK/ITPR3/ITPK1/SYNJ2/INPP5F/PIP4P1/INPP1/DGKQ/DGKB/IMPA2	4.9808734098192
Organismal Systems	Immune system	hsa04611	Platelet activation	43/1655	126/9376	1.93338128806407	PRKACB/LCP2/ACTB/STIM1/SYK/PLCG2/VAMP8/FCER1G/PPP1R12A/GNAQ/PIK3R1/FYN/LYN/PLCB1/ARHGEF1/RAP1A/FERMT3/MAPK14/PIK3CB/ADCY7/RASGRP2/GNAI2/MYL12A/ROCK1/MAPK1/ADCY9/TLN1/PPP1CA/ITGB1/ITPR1/RAP1B/PIK3CG/GNA13/RASGRP1/TBXAS1/SNAP23/ITPR2/PLCB2/ARHGEF12/ITPR3/PPP1CB/PIK3R5/TLN2	4.88338941317069
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	31/1655	83/9376	2.11593928584428	SFMBT2/AUTS2/L3MBTL4/SFMBT1/MBD5/TFDP1/LCOR/JARID2/ASXL2/DCAF7/YAF2/EP300/SUZ12/AEBP2/MTF2/CBX4/PHC3/UBE2D2/YY1/HDAC2/SCMH1/KDM2A/RNF2/RYBP/TEX10/MBD6/L3MBTL2/USP45/AURKB/L3MBTL1/PCGF6	4.72769559421103
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	12/1655	20/9376	3.39915407854985	MSMO1/SQLE/FDFT1/DHCR24/CYP51A1/EBP/SOAT1/LBR/DHCR7/LSS/HSD17B7/TM7SF2	4.97251260182901
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	50/1655	163/9376	1.73780883361444	MMP9/STAT4/BCL2/SOS1/CASP3/BRAF/IRF7/KRAS/NFKB1/PIK3R1/MAP2K4/MAP3K1/CASP8/NFATC3/JAK2/SOS2/PTK2B/MAPK14/PIK3CB/BAX/EP300/IRAK4/MAPK8/MAPK1/TGFBR1/SMAD4/PCNA/TBK1/CREB1/CASP10/YWHAZ/MAP3K7/TAB2/VDAC3/ATF6B/IKBKB/IFIH1/MAP2K1/APAF1/DDB2/E2F3/RB1/TRAF6/JAK3/ATP6AP1/BIRC5/CASP9/CDK2/MAP2K6/CCNA2	4.39931417756465
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	29/1655	78/9376	2.10631342474243	PIP4K2A/PLCG2/SACM1L/INPP4A/PI4KA/PLCB1/PIKFYVE/PIK3C2A/INPP5B/PIK3CB/PPIP5K2/MTMR1/MTMR3/PIK3CG/IMPA1/MTM1/PI4K2B/PLCH2/INPP5A/SYNJ1/PLCB2/FIG4/IPPK/ITPK1/SYNJ2/INPP5F/INPP1/ISYNA1/IMPA2	4.5423288640768
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	31/1655	87/9376	2.01865472097788	AREG/BCL2/SOS1/CASP3/LEF1/BRAF/RAC2/KRAS/PIK3R1/CTNNB1/MSH3/SOS2/GSK3B/PIK3CB/BAX/MAPK8/MAPK1/TGFBR1/SMAD4/POLK/MAP2K1/MSH2/DDB2/MTOR/RPS6KB2/APPL1/EREG/APC/BIRC5/CASP9/BAK1	4.41926462839943
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	28/1655	77/9376	2.0600933809393	CDKN2A/PLD1/BRAF/RAC2/ARHGEF6/KRAS/NFKB1/PIK3R1/CDK6/PIK3CB/BAX/MAPK8/MAPK1/TGFBR1/SMAD4/RALBP1/IKBKB/POLK/MAP2K1/DDB2/BCL2L1/MTOR/E2F3/RB1/RPS6KB2/BRCA2/CASP9/BAK1	4.32433392320285
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	61/1655	216/9376	1.59991048450263	APOA1/MMP9/VAV3/LDLR/PPP3CA/BCL2/CASP3/NFE2L2/POU2F1/IRF7/KRAS/CAMK2G/NFKB1/PIK3R1/CAMK2D/MAP2K4/LYN/PLCB1/ARHGEF1/ERN1/CASP8/NFATC3/HSPA4/JAK2/RAP1A/GSK3B/CCL3/PPP3CC/MAPK14/PIK3CB/TNFRSF10A/BAX/IRAK4/MAPK8/MAPK1/PPP3R1/CALM3/ITPR1/RAP1B/TBK1/IL18/ATF6/TNFSF10/MAP3K7/PYCARD/TAB2/IKBKB/ERO1A/RXRA/APAF1/BCL2L1/NCF1/PLCB2/MIB2/TRAF6/CASP1/MIB1/CASP9/CASP6/MAP2K6/LY96	4.12965196227574
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	64/1655	232/9376	1.56282946140223	IQGAP2/ITGAD/VAV3/ITGA1/PIP4K2A/SSH2/ARPC5L/SOS1/RRAS2/PFN1/ACTB/IQGAP1/ITGAM/BRAF/TIAM1/CYFIP2/RGCC/RAC2/ARHGEF6/PPP1R12A/ACTR2/ACTN4/KRAS/PIK3R1/ARHGEF7/ARHGEF1/ACTR3/PIKFYVE/ITGAL/SOS2/ITGAX/DIAPH1/FGD3/PIK3CB/LIMK1/NCKAP1L/PPP1R12B/MYL12A/ROCK1/ARPC4/MAPK1/CFL1/ARPC1B/PPP1CA/ITGB1/PAK2/ARPC2/ITGA4/GNA13/SPATA13/MAP2K1/MSN/ARPC3/SSH1/ARHGEF12/PDGFC/PPP1CB/APC/DIAPH3/CHRM5/ITGB5/ITGA3/ACTR3C/PAK1	4.01883862268449
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/1655	75/9376	2.03949244712991	BCL2/CDKN2A/CCND3/CASP3/SERPINE1/COP1/CDK6/ATR/CASP8/SESN1/IGFBP3/TNFRSF10A/BAX/ZMAT3/CCNG1/APAF1/DDB2/BCL2L1/THBS1/RCHY1/CASP9/RRM2B/CDK2/CDK1/CCNB1/CHEK1/GTSE1	4.18441748978736
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	67/1655	248/9376	1.53053308644382	PTPRC/BCL2/ARPC5L/KPNA1/PFN1/CASP3/ACTB/LEF1/CYFIP2/ABI1/ARF6/ACTR2/NFKB1/CYTH1/MAP2K4/CTNNB1/ACTR3/CASP8/VPS41/PIK3C2A/CYTH4/EXOC4/MAPK14/PIK3CB/TNFRSF10A/BAX/NCKAP1L/MLKL/SNX18/IRAK4/MYL12A/MAPK8/ARPC4/ELMO1/MAPK1/KPNA3/ARPC1B/DYNLRB1/EXOC2/ARPC2/PIK3CG/IL18/TNFSF10/MAP3K7/PYCARD/TAB2/IKBKB/MAP2K1/KLC1/ARPC3/TRAF6/CYTH2/CASP1/VPS39/NOD1/CSE1L/TUBA1B/ACTR1A/FBXO22/RAB5B/ACTR3C/MAP2K6/PAK1/VPS33A/ARL8A/BAK1/LY96	3.92011095411683
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	56/1655	200/9376	1.58627190332326	ARPC5L/MYO1F/CASP3/ACTB/CYFIP2/SEC24B/ABI1/MYO1E/HCLS1/WIPF3/ARF6/ACTR2/NFKB1/WIPF1/FYN/CYTH1/ARHGEF1/ACTR3/CASP8/CYTH4/MAPK14/TMED10/MYO1G/TNFRSF10A/NCK1/BAX/NCKAP1L/IRAK4/PTPN6/MAPK8/ROCK1/ARPC4/SEC24D/MAPK1/ARPC1B/ITGB1/PAK2/ARPC2/IL18/TNFSF10/GNA13/MAP3K7/PYCARD/TAB2/IKBKB/SEC24C/ARPC3/TRAF6/ARHGEF12/CYTH2/CASP1/CASP9/TUBA1B/ACTR3C/PAK1/BAK1	3.88003137858149
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	27/1655	77/9376	1.98651861733433	CDKN2A/SOS1/BRAF/KRAS/NFKB1/PIK3R1/CDK6/SOS2/BCR/PIK3CB/BAX/CBL/MAPK1/RUNX1/TGFBR1/SMAD4/CTBP2/IKBKB/POLK/MAP2K1/HDAC2/DDB2/BCL2L1/E2F3/RB1/CDKN1B/BAK1	4.02420767784632
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	35/1655	110/9376	1.80258170832189	RPS6KA3/PRKACB/BRAF/STK10/KRAS/PIK3R1/CDC27/SPDYE2/MAPK14/PIK3CB/ADCY7/GNAI2/MAPK8/SPDYA/MAPK1/ADCY9/ANAPC5/ANAPC10/BUB1/CPEB3/MAP2K1/FZR1/MAD2L1/RPS6KA1/ANAPC4/KIF22/ANAPC15/CPEB2/CDK2/CDK1/SPDYE5/CCNB1/CDC23/AURKA/CCNA2	3.92001124782333
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	23/1655	63/9376	2.06826835467319	MNAT1/POLR2J/CCNH/POLR2K/POLR2J3/RBX1/PCNA/RPA1/POLR2G/RFC2/POLE4/DDB2/POLR2I/LIG1/ERCC5/GTF2H5/ERCC3/POLR2L/RFC3/GTF2H2/POLE/POLD3/POLD1	3.93870720733663
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	37/1655	120/9376	1.74678751258812	RPS6KA3/BCL2/SOS1/ARHGDIB/BRAF/PLCG2/MATK/KRAS/CAMK2G/NFKB1/PIK3R1/CAMK2D/MAP3K1/RPS6KA5/SOS2/RAP1A/GSK3B/MAPK14/PIK3CB/BAX/IRAK4/MAPK8/MAPK1/CALM3/SH2B3/RAP1B/IKBKB/MAP2K5/FOXO3/MAP2K1/ARHGDIA/SORT1/TRAF6/RPS6KA1/PRDM4/GAB1/NFKBIE	3.81174516736764
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	24/1655	67/9376	2.02934571853722	RPS6KA3/PRKACB/PPP3CA/BRAF/GNAQ/KRAS/CAMK2G/CAMK2D/PLCB1/RAP1A/PPP3CC/EP300/MAPK1/PPP3R1/CALM3/PPP1CA/ITPR1/RAP1B/MAP2K1/ITPR2/PLCB2/ITPR3/PPP1CB/RPS6KA1	3.91466866621379
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	61/1655	227/9376	1.52238178261043	PRKACB/PPP3CA/CCR1/CDKN2A/SOS1/CASP3/RAC2/GNAQ/KRAS/NFKB1/PIK3R1/CDK6/PLCB1/ARHGEF1/CTNNB1/CASP8/NFATC3/SOS2/PTK2B/TAPBP/GSK3B/CCL3/PPP3CC/MAPK14/PIK3CB/BAX/ADCY7/GNAI2/ROCK1/MAPK1/PPP3R1/CALM3/ADCY9/ITPR1/TBK1/CREB1/HLA-A/TRAF5/GNA13/ATF6B/IKBKB/MAP2K1/MTOR/E2F3/ITPR2/RB1/RPS6KB2/PTGER4/PLCB2/ARHGEF12/ITPR3/SP1/PTGER2/GNB1/TAP2/AKAP13/CASP9/HLA-C/MAP2K6/GNGT2/BAK1	3.68860371141716
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	36/1655	117/9376	1.74315593771787	DPF3/SMARCA2/ACTB/ARID1B/ARID2/CHD3/PHF6/RSF1/MEAF6/SMARCB1/ARID1A/BPTF/BRD7/BAZ2A/ACTR6/BAZ1B/GATAD2A/GATAD2B/SMARCA5/EP400/SMARCD1/YY1/SMARCE1/HDAC2/EPC1/SMARCC1/MTA3/CDK2AP2/DPF2/INO80E/UCHL5/SS18L1/CHRAC1/SMARCD2/MCRS1/MTA2	3.74488686484275
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	53/1655	193/9376	1.55574409467307	VAV3/PRKACB/XCL1/CCR1/ITK/SOS1/XCL2/BRAF/TIAM1/PLCG2/RAC2/GNAQ/KRAS/WAS/NFKB1/PIK3R1/DOCK2/LYN/PLCB1/JAK2/SOS2/PTK2B/RAP1A/GSK3B/CCL3/PIK3CB/ADCY7/RASGRP2/GNAI2/FGR/ROCK1/ELMO1/MAPK1/ADCY9/GRK2/PREX1/RAP1B/CXCR3/PIK3CG/CCL8/IKBKB/CCL28/FOXO3/MAP2K1/NCF1/PLCB2/JAK3/GNB1/PIK3R5/CCL23/CCL21/PAK1/GNGT2	3.61167846756209
Human Diseases	Infectious disease: viral	hsa05162	Measles	40/1655	136/9376	1.66625199928914	MX1/EIF2AK2/BCL2/CCND3/CASP3/IRF7/NFKB1/PIK3R1/CDK6/IL2RB/ADAR/IRF9/CASP8/OAS2/OAS1/GSK3B/PIK3CB/BAX/IRAK4/CD46/MAPK8/IL2RG/IFNAR2/TBK1/OAS3/MAP3K7/TAB2/IKBKB/IFIH1/APAF1/BCL2L1/MSN/TRAF6/CBLB/CDKN1B/RCHY1/JAK3/CASP9/CDK2/BAK1	3.6234298260076
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	20/1655	54/9376	2.0982432583641	ATR/USP1/FANCC/RPA1/FANCL/BLM/CENPX/POLK/FANCI/BRIP1/BRCA2/REV1/FANCM/RAD51C/FANCA/FANCB/POLH/BRCA1/FANCD2/RMI1	3.74704352354586
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	17/1655	44/9376	2.18884921724801	MNAT1/CCNH/TAF15/GTF2I/GTF2F2/TAF3/TAF2/TAF1/TBPL1/GTF2A2/GTF2H5/ERCC3/TBP/TAF5L/GTF2H2/TAF6/TAF5	3.65943140113733
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	32/1655	105/9376	1.72655445259675	PPP3CA/RRAS2/SYK/PLCG2/FCER1G/LSP1/KRAS/NFKB1/PIK3R1/MALT1/IRF9/CASP8/NFATC3/PPP3CC/MAPK14/PIK3CB/KSR1/MAPK8/MAPK1/PPP3R1/CALM3/ITPR1/PYCARD/IKBKB/ITPR2/CYLD/ARHGEF12/BCL10/CASP1/CBLB/ITPR3/PAK1	3.46615028322548
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	54/1655	205/9376	1.49231154668042	ISG15/EIF2AK2/BCL2/CCND3/CASP3/CD58/SYK/PLCG2/IRF7/NFKB1/PIK3R1/CDK6/MAP2K4/LYN/IRF9/CASP8/ITGAL/OAS2/OAS1/CD247/TAPBP/MAPK14/PIK3CB/BAX/IRAK4/MAPK8/RBPJ/IFNAR2/TBK1/OAS3/HLA-A/TRAF5/MAP3K7/TAB2/RUNX3/IKBKB/PSMD1/POLK/APAF1/HDAC2/DDB2/E2F3/RB1/TRAF6/CDKN1B/JAK3/TAP2/CASP9/HLA-C/CDK2/MAP2K6/BAK1/NFKBIE/CCNA2	3.29956331697951
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	54/1655	205/9376	1.49231154668042	RASA2/SP100/PRKACB/EIF2AK2/KAT2B/CDKN2A/CCND3/CASP3/HDAC9/DLG1/SYK/ACTN4/IRF7/KRAS/NFKB1/PIK3R1/CDK6/LYN/IRF9/CASP8/PIK3CB/BAX/EP300/MAPK1/RBPJ/UBE3A/CREB1/HLA-A/REL/TRAF5/HDAC8/RBL1/RANBP1/YWHAZ/VDAC3/YWHAH/ATF6B/TBPL1/POLB/HDAC2/RB1/SND1/GTF2A2/CDKN1B/JAK3/TBP/GTF2H2/HLA-C/CDK2/CDC20/CDK1/BAK1/CHEK1/CCNA2	3.29956331697951
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	30/1655	98/9376	1.73426228497441	PTPRC/VAV3/ARPC5L/PLD1/SYK/PLCG2/RAC2/ARF6/ACTR2/WAS/PIK3R1/LYN/ACTR3/PLPP3/PIK3CB/LIMK1/ARPC4/MAPK1/CFL1/ARPC1B/ARPC2/ASAP1/PLPP1/MAP2K1/ARPC3/LAT/RPS6KB2/NCF1/ACTR3C/PAK1	3.38286709919456
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	24/1655	73/9376	1.86255018002731	EML4/CDKN2A/SOS1/BRAF/PLCG2/KRAS/PIK3R1/CDK6/STK4/SOS2/PIK3CB/BAX/MAPK1/POLK/FOXO3/MAP2K1/RXRA/DDB2/E2F3/RB1/JAK3/FHIT/CASP9/BAK1	3.42517015178403
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	31/1655	103/9376	1.70507728859297	PPP2R2B/PPP2R5A/CPSF6/PPP2R5E/RNGTT/UPF2/PAPOLG/PPP2R2A/PABPN1/WDR33/FIP1L1/PPP1CA/RNMT/ACIN1/PAPOLA/MSI2/DDX19B/PPP2R3C/SYMPK/PNN/UPF3A/ALYREF/UPF3B/NUDT21/MAGOH/PYM1/PPP1CB/CSTF3/NCBP1/DDX19A/GLE1	3.33114140963025
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	36/1655	125/9376	1.63159395770393	BCL2/SGMS1/PPP2R2B/PLD1/CTSD/RAC2/FCER1G/PPP2R5A/GNAQ/KRAS/NFKB1/PIK3R1/FYN/PLCB1/PPP2R5E/ASAH1/MAPK14/PIK3CB/PPP2R2A/BAX/GNAI2/MAPK8/ROCK1/MAPK1/GNA13/ORMDL2/CERS6/NSMAF/PPP2R3C/SGPP1/MAP2K1/ORMDL3/PLCB2/SPTSSB/S1PR4/SGPL1	3.2911410361233
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	31/1655	104/9376	1.68868231466419	ETNK1/SGMS1/CHKA/PLD1/AGPAT4/LCLAT1/SELENOI/DGKE/AGPAT5/LPIN1/LYPLA1/GPD2/DGKD/DGKZ/PLPP3/PLAAT2/GPCPD1/PLPP1/GPD1L/LYPLA2/LPIN2/PLAAT3/CEPT1/PTDSS1/CRLS1/GNPAT/PCYT1A/LPCAT4/DGKQ/PCYT2/DGKB	3.26961599786327
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	51/1655	196/9376	1.47412294222825	EIF2AK2/PPP3CA/CCR1/CASP3/LEF1/SYK/PLCG2/IRF7/KRAS/NFKB1/PIK3R1/CDK6/MAP2K4/LYN/IRF9/CTNNB1/CASP8/NFATC3/JAK2/GSK3B/PPP3CC/MAPK14/PIK3CB/BAX/EP300/MAPK8/MAPK1/PPP3R1/CALM3/ITPR1/PREX1/IFNAR2/TBK1/CREB1/HLA-A/PIK3CG/IKBKB/MAP2K1/MTOR/E2F3/ITPR2/RB1/ZFP36/ITPR3/GNB1/PIK3R5/CASP9/HLA-C/MAP2K6/GNGT2/BAK1	3.105600063408
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	28/1655	93/9376	1.70566871325082	YES1/ACTB/IQGAP1/LEF1/PTPN1/RAC2/ACTN4/WAS/FER/FYN/NLK/CTNNB1/LMO7/HEG1/RAP1A/EP300/PTPN6/MYL12A/SMURF2/ROCK1/NECTIN3/MAPK1/TGFBR1/SMAD4/RAP1B/PDCD10/MAP3K7/SMURF1	3.166255979176
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	33/1655	115/9376	1.62568238539341	MEF2A/STK39/PRKACB/BCL2/BGLAP/PLD1/BRAF/GNAQ/PLCB1/GATA3/ARHGEF1/OXSR1/ADCY7/GNAI2/MAPK1/ADCY9/ITPR1/PDE4A/CREB1/GNA13/ATF6B/PDE4B/MAP2K1/RXRA/ITPR2/PLCB2/VDR/ITPR3/HBEGF/SP1/RUNX2/TNFSF11/AKAP13	3.12551629690789
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	16/1655	44/9376	2.0600933809393	PARP4/HMGB1/PARP1/PCNA/MPG/RFC2/POLE4/POLB/LIG1/MBD4/RFC3/POLE/FEN1/POLD3/POLD1/UNG	3.26310431135006
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	42/1655	156/9376	1.52526144550314	MX1/LDLR/EIF2AK2/SOS1/CASP3/PPP2R2B/BRAF/PIAS1/RSAD2/IRF7/KRAS/NFKB1/PIK3R1/CDK6/IRF9/CTNNB1/CASP8/OAS2/OAS1/SOS2/GSK3B/PIK3CB/PPP2R2A/BAX/MAPK1/IFNAR2/TBK1/OAS3/YWHAZ/YWHAH/IKBKB/MAP2K1/RXRA/APAF1/E2F3/RB1/TRAF6/PSME3/IFIT1/CASP9/CDK2/BAK1	3.06281118337687
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	62/1655	250/9376	1.4049836858006	OSBPL3/BORCS5/CTSD/GNPTAB/VAMP8/WDR7/AP3B1/VPS13C/SLC15A4/MANBA/CTSA/BORCS7/PIKFYVE/ACP5/VPS41/AP1S2/CD164/LITAF/ASAH1/VPS13A/ATP6V1A/FUCA1/SPG11/DMXL1/GALC/AP1S3/CTSZ/ATP6V0A2/SLC38A9/AP2B1/MFSD8/OSTM1/RPTOR/VPS26A/GPR155/ATP6V0C/DTNBP1/SUMF1/CTSK/IGF2R/NPC2/MTOR/KXD1/LAMTOR4/SORT1/ARSB/FIG4/GNS/AP3S1/STX17/VPS39/ABCA5/CLN6/SLC36A4/ATP6AP1/TTI1/CD68/AGA/VPS33A/ARL8A/ABCA2/AP4B1	3.00479717147903
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	45/1655	170/9376	1.49962679936023	DPF3/CDKN2A/SOS1/SMARCA2/ACTB/LEF1/BRAF/PLCG2/NFE2L2/GSTP1/KRAS/PIK3R1/CDK6/ARID1B/CTNNB1/ARID2/SOS2/WNT6/GSK3B/MGST2/WNT4/PIK3CB/BAX/MAPK1/SMARCB1/ARID1A/TGFBR1/SMAD4/BRD7/SMARCD1/POLK/SMARCE1/MAP2K1/DDB2/BCL2L1/MTOR/E2F3/SMARCC1/RB1/RPS6KB2/APC/SMARCD2/GAB1/GSTA4/BAK1	3.04356486382272
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	47/1655	180/9376	1.47926149714669	SP100/BST2/EIF2AK2/BCL2/CASP3/SYK/ZC3HAV1/POU2F1/IRF7/NFKB1/PIK3R1/IRF9/CASP8/OAS2/OAS1/JAK2/TAPBP/PIK3CB/BAX/TNFSF14/IRAK4/PPP1CA/IFNAR2/TBK1/OAS3/HLA-A/TRAF5/PILRB/MAP3K7/TAB2/IKBKB/IFIH1/PML/SRSF9/SRSF4/DAXX/APAF1/BCL2L1/MTOR/ALYREF/TRAF6/PPP1CB/HCFC2/TAP2/CASP9/HLA-C/BAK1	3.00577987529008
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	26/1655	86/9376	1.71275205508326	AREG/SOS1/BRAF/PLCG2/KRAS/CAMK2G/PIK3R1/CAMK2D/MAP2K4/SOS2/GSK3B/PIK3CB/NCK1/CBL/MAPK8/MAPK1/PAK2/MAP2K1/MTOR/RPS6KB2/CBLB/HBEGF/EREG/CDKN1B/GAB1/PAK1	3.07416878075608
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	27/1655	91/9376	1.68090036851366	VAV3/PPP3CA/SOS1/PIK3AP1/SYK/PLCG2/RAC2/KRAS/NFKB1/PIK3R1/MALT1/LYN/NFATC3/SOS2/GSK3B/PPP3CC/PIK3CB/PTPN6/DAPP1/MAPK1/PPP3R1/RASGRP3/CARD11/IKBKB/MAP2K1/BCL10/NFKBIE	3.02176837985103
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	7/1655	13/9376	3.05052289100627	MRE11/XRCC4/DCLRE1C/XRCC5/NHEJ1/FEN1/LIG4	3.42512674833009
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	45/1655	174/9376	1.46515262006459	BCL2/CUL1/SEC24B/NFE2L2/MAN1A1/MAGT1/ERN1/UBE2J1/SAR1A/NGLY1/BAX/SEC23B/MAPK8/SEC24D/RBX1/UBE2G1/DNAJC1/MAN1A2/SEC31A/STT3B/TRAM1/ATF6/ATF6B/UBQLN1/BCAP31/MOGS/ERO1A/SSR1/UBE2D2/SEC24C/DERL1/FBXO6/EDEM3/SEC23A/UGGT1/DNAJC10/BAG2/RNF185/STT3A/GANAB/SEC61A2/SEC31B/BAK1/DERL3/SYVN1	2.86732447808596
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	37/1655	137/9376	1.53003285774142	BCL2/CASP3/ACTB/CTSD/LMNB1/PARP4/KRAS/PRF1/NFKB1/PIK3R1/ERN1/CASP8/GZMB/PIK3CB/TNFRSF10A/BAX/MAPK8/MAPK1/CASP2/ITPR1/CTSZ/PARP1/CASP10/TNFSF10/IKBKB/CTSK/MAP2K1/DAXX/APAF1/BCL2L1/ITPR2/ITPR3/BIRC5/CASP9/TUBA1B/CASP6/BAK1	2.89333322519765
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	23/1655	75/9376	1.73734541792548	BCL2/CDKN2A/CASP3/GSTP1/PIK3R1/CASP8/MSH3/MGST2/PIK3CB/TOP2B/BAX/MAPK1/MSH2/APAF1/BCL2L1/BIRC5/ATP7A/CASP9/POLH/GSTA4/BRCA1/BAK1/SLC31A1	2.96814187664449
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	18/1655	56/9376	1.82097539922313	PRKACB/BCL2/CUL1/CSNK1G1/GSK3B/SMURF2/CSNK1G3/GRK2/SPOP/BTRC/CUL3/MOSMO/FBXW11/SMURF1/CSNK1E/SUFU/KIF3A/DISP1	2.85275228500087
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	22/1655	73/9376	1.70733766502504	MX1/BST2/KAT2B/MDFIC/SAMHD1/CPSF6/PDCD6IP/RANBP2/APOBEC3D/PSIP1/EP300/CCNT1/CCNT2/SMARCB1/ELL/XPO1/MLLT3/NELFA/TSG101/CDK9/APOBEC3H/ELL2	2.80882424417284
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	43/1655	169/9376	1.44145587157439	PRKACB/BCL2/BIRC6/RRAS2/CTSD/VAMP8/KRAS/PIK3R1/ERN1/VPS41/HMGB1/UVRAG/PIK3CB/DDIT4/MAPK8/MAPK1/RUBCN/DAPK2/ITPR1/ATG7/GABARAPL1/MTMR3/TBK1/ATG16L1/MAP3K7/ATG10/PRKAA1/TAX1BP1/SUPT20H/RPTOR/STX7/MAP2K1/BCL2L1/MTOR/ATG16L2/RPS6KB2/WDR45B/TRAF6/RAB8A/ATG2B/STX17/VPS39/VPS33A	2.68113967480202
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	37/1655	142/9376	1.47615846134207	TYROBP/PPP3CA/LCP2/SYK/PLCG2/NFKB1/PIK3R1/FYN/IRF9/ACP5/PPP3CC/MAPK14/PIK3CB/MAPK8/MAPK1/PPP3R1/CSF1/ITPR1/TGFBR1/IFNAR2/CREB1/MAP3K7/TEC1/SOCS1/TAB2/FOSL2/IKBKB/CTSK/MAP2K1/ITPR2/NCF1/CYLD/TRAF6/ITPR3/TNFSF11/TMEM64/MAP2K6	2.64696747127387
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	12/1655	33/9376	2.0600933809393	VAMP8/VTI1A/STX3/STX8/STX16/VAMP2/STX2/STX7/SNAP23/STX17/STX6/VAMP4	2.82426718095891
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	36/1655	138/9376	1.47789307763037	PRKACB/SOS1/BRAF/PTPN1/KRAS/PIK3R1/PRKAR2A/SOS2/GSK3B/PHKB/PIK3CB/CBL/MAPK8/MAPK1/PRKAR1A/CALM3/PPP1CA/PRKAR2B/HKDC1/EIF4E/ACACA/PRKAA1/SOCS1/RPTOR/IKBKB/INPP5A/MAP2K1/MTOR/SOCS2/RPS6KB2/MKNK1/CBLB/PPP1CB/SOCS4/PHKA2/PRKAB1	2.61835883795193
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/1655	37/9376	1.99049563158324	LEF1/BRAF/KRAS/TPM3/CTNNB1/BAX/MAPK1/POLK/MAP2K1/RXRA/DDB2/CCDC6/BAK1	2.79480235063341
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	19/1655	62/9376	1.7361270831303	MAML3/KAT2B/ITCH/NOTCH2/DTX3L/SPEN/EP300/NUMB/RBPJ/CTBP2/APH1B/PSENEN/LFNG/HDAC2/MAML2/TLE3/TLE1/APH1A/NCSTN	2.69233058787594
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	26/1655	93/9376	1.5838352337329	BCL2/CASP3/NFKB1/PIK3R1/CDK6/PIK3CB/BAX/ITGB1/TRAF5/CKS2/IKBKB/POLK/RXRA/APAF1/DDB2/BCL2L1/E2F3/RB1/TRAF6/CDKN1B/CKS1B/FHIT/CASP9/ITGA3/CDK2/BAK1	2.61960288864808
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	21/1655	71/9376	1.6756393344964	PRL/SOS1/KRAS/NFKB1/PIK3R1/PRLR/JAK2/SOS2/GSK3B/MAPK14/PIK3CB/MAPK8/MAPK1/SOCS1/FOXO3/MAP2K1/SOCS2/TNFSF11/SOCS4/SOCS7/CISH	2.64565842157715
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	46/1655	187/9376	1.39359258122365	BCL2/IFI16/IRF7/NFKB1/PLCB1/IRF9/CASP8/OAS2/OAS1/NEK7/MAPK14/PKN2/IRAK4/MAPK8/GPSM3/MFN1/MAPK1/ITPR1/DNM1L/GABARAPL1/IFNAR2/TBK1/OAS3/GBP3/TRAF5/ATG16L1/IL18/MAP3K7/PYCARD/TAB2/VDAC3/CARD16/IKBKB/BCL2L1/TRPV2/ITPR2/ANTXR2/PLCB2/TRAF6/RNF31/BRCC3/CASP1/ITPR3/MCU/NOD1/NLRP1	2.51698972360159
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	38/1655	149/9376	1.4448305926722	SOS1/RRAS2/PLD1/SYK/PLCG2/AGPAT4/FCER1G/ARF6/KRAS/PIK3R1/DGKE/FYN/CYTH1/PLCB1/AGPAT5/SOS2/CYTH4/PTK2B/DGKD/DGKZ/PLPP3/PIK3CB/LPAR3/ADCY7/MAPK1/ADCY9/PIK3CG/GNA13/PLPP1/MAP2K1/MTOR/PLCB2/CYTH2/PDGFC/PIK3R5/GAB1/DGKQ/DGKB	2.53399283521061
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	43/1655	173/9376	1.40812741211603	MX1/EIF2AK2/KPNA1/CCND3/CASP3/ACTB/RSAD2/PRSS3/IRF7/NFKB1/PIK3R1/CDK6/ADAR/IRF9/CASP8/OAS2/OAS1/JAK2/PIK3CB/TNFRSF10A/BAX/EP300/PABPN1/IRAK4/MAPK1/IFNAR2/TBK1/OAS3/IL18/TNFSF10/TRIM25/PYCARD/XPO1/IKBKB/IFIH1/PML/MAP2K1/APAF1/CASP1/KPNA6/KPNA5/CASP9/BAK1	2.5084298892256
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	18/1655	59/9376	1.72838342977111	DPYD/CDA/NT5C3A/NT5C/CMPK1/NME7/NUDT2/NT5C2/UCK2/CMPK2/TK2/DCK/RRM1/CDADC1/NME1/AK9/RRM2B/TYMS	2.59833938580705
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	18/1655	59/9376	1.72838342977111	SOS1/LEF1/BRAF/KRAS/PIK3R1/CTNNB1/SOS2/GSK3B/PIK3CB/BAX/MAPK1/POLK/FOXO3/MAP2K1/DDB2/APC/CASP9/BAK1	2.59833938580705
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	27/1655	99/9376	1.54507003570448	MMP9/PRKACB/BCL2/CDKN2A/SOS1/BRAF/KRAS/PIK3R1/NCOR1/NOTCH2/SOS2/NCOA3/MAPK14/PIK3CB/BAX/ADCY7/MAPK8/MAPK1/ADCY9/MAP2K1/MTOR/E2F3/RB1/RPS6KB2/HBEGF/SP1/CDKN1B	2.52414319067465
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	27/1655	99/9376	1.54507003570448	SOS1/CHKA/PLD1/RAC2/KRAS/WAS/PIK3R1/DGKE/SLC44A1/SOS2/LYPLA1/DGKD/DGKZ/PLPP3/PIK3CB/GPCPD1/MAPK8/MAPK1/PLPP1/MAP2K1/MTOR/RPS6KB2/PDGFC/SP1/PCYT1A/DGKQ/DGKB	2.52414319067465
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	32/1655	122/9376	1.48596899608737	PRKACB/SOS1/PLCG2/GNAQ/KRAS/PIK3R1/MAP2K4/PLCB1/MAP3K1/JAK2/SOS2/GSK3B/MAPK14/IGFBP3/PIK3CB/EP300/ADCY7/GNAI2/MAPK8/MAPK1/ADCY9/ITPR1/CREB1/SOCS1/ATF6B/MAP2K1/MTOR/SOCS2/ITPR2/PLCB2/ITPR3/MAP2K6	2.50133345487896
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	49/1655	204/9376	1.36077246608613	MMP9/VAV3/PRKACB/SOS1/RRAS2/CASP3/ACTB/IQGAP1/BRAF/TIAM1/PLCG2/HCLS1/PPP1R12A/KRAS/CAMK2G/PIK3R1/CAMK2D/ARHGEF1/CTNNB1/SOS2/WNT6/MAPK14/WNT4/PIK3CB/CBL/PPP1R12B/PLAUR/PTPN6/ROCK1/MAPK1/PPP1CA/ITGB1/ITPR1/DROSHA/MAP2K1/LUM/MTOR/MSN/ITPR2/RPS6KB2/ARHGEF12/THBS1/ITPR3/HBEGF/PPP1CB/ITGB5/VTN/GAB1/PAK1	2.41192781962727
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	9/1655	23/9376	2.21683961644555	MSH3/PCNA/RPA1/RFC2/MSH2/LIG1/RFC3/POLD3/POLD1	2.70501484223071
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	20/1655	69/9376	1.6421034195893	VAV3/LCP2/SOS1/SYK/PLCG2/RAC2/FCER1G/KRAS/PIK3R1/FYN/MAP2K4/LYN/SOS2/MAPK14/PIK3CB/MAPK8/MAPK1/MAP2K1/LAT/MAP2K6	2.47840645904848
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	22/1655	78/9376	1.59789294290805	DHX36/ZCCHC7/TENT4B/XRN1/CNOT2/PAN3/LSM6/PARN/NUDT16/CNOT7/CNOT9/LSM5/PNPT1/CNOT10/CNOT6L/CNOT4/MTREX/EXOSC8/EXOSC9/CNOT3/EXOSC1/DIS3L	2.45484354746156
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	55/1655	235/9376	1.32591116539179	DPF3/RPS6KA3/PRKACB/SOS1/SMARCA2/ACTB/KRAS/ARID1B/SOS2/MAPK14/NDUFB3/COX8A/ADCY7/NDUFS8/SMARCB1/ARID1A/UQCR11/ADCY9/PLIN1/KDM3B/NDUFS6/CREB1/ATP5MG/PRKAA1/NDUFAF8/RPTOR/UQCR10/COX6B1/NDUFB9/NDUFB6/SMARCD1/NDUFS7/ACSL5/SMARCE1/COX7A2/COX5B/MTOR/NDUFA7/ATP5MF/SMARCC1/COX17/RPS6KB2/UQCRQ/NDUFA13/NDUFAB1/RPS6KA1/SMARCD2/NDUFC2/NDUFAF7/ATP5F1E/PRKAB1/COX6A2/SLC25A20/CNR1/COX10	2.34252468946411
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	20/1655	70/9376	1.61864479930945	SOS1/BRAF/KRAS/PIK3R1/SOS2/RAP1A/PIK3CB/EP300/RBX1/MAPK1/PAK2/ETS1/RAP1B/ARNT/MAP2K1/CUL2/EGLN1/PRCC/GAB1/PAK1	2.40523061583419
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	25/1655	93/9376	1.52291849397395	STAT4/MAML3/PPP3CA/ZAP70/NFKB1/IL2RB/GATA3/NFATC3/JAK2/NOTCH2/CD247/PPP3CC/MAPK14/MAPK8/MAPK1/PPP3R1/RBPJ/IL2RG/RUNX3/IKBKB/MAML2/LAT/JAK3/IL4R/NFKBIE	2.34627634338413
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	25/1655	93/9376	1.52291849397395	PRKACB/SOS1/PLD1/GNAQ/KRAS/CAMK2G/CAMK2D/MAP2K4/PLCB1/MAP3K1/SOS2/PTK2B/MAPK14/ADCY7/MAPK8/MAPK1/CALM3/ADCY9/ITPR1/MAP2K1/ITPR2/PLCB2/ITPR3/HBEGF/MAP2K6	2.34627634338413
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	11/1655	32/9376	1.94743202416918	BCL2/BIRC6/CASP3/CASP8/BAX/MAPK8/APAF1/BCL2L1/BIRC5/CASP9/BAK1	2.48544693659033
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	15/1655	49/9376	1.73426228497441	GALNT1/GALNT10/GALNT3/GALNT11/GXYLT1/B4GALT1/ST3GAL3/GALNT2/C1GALT1/LFNG/GALNT7/GALNT6/B3GLCT/XXYLT1/FUT11	2.3857566009677
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	23/1655	85/9376	1.53295183934601	CDA/ADK/NT5C3A/GMPS/NT5C/CMPK1/NUDT16/NME7/AMPD3/HPRT1/NT5C2/UCK2/AK2/AK3/CMPK2/TK2/DCK/RRM1/IMPDH1/NME1/AK9/RRM2B/TYMS	2.28514656037327
Human Diseases	Cancer: specific types	hsa05214	Glioma	21/1655	76/9376	1.56539990459533	CDKN2A/SOS1/BRAF/PLCG2/KRAS/CAMK2G/PIK3R1/CDK6/CAMK2D/SOS2/PIK3CB/BAX/MAPK1/CALM3/POLK/MAP2K1/DDB2/MTOR/E2F3/RB1/BAK1	2.29123119604082
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	24/1655	90/9376	1.51073514602215	EML4/PPP3CA/ZAP70/KRAS/NFKB1/PIK3R1/NFATC3/JAK2/CD247/PPP3CC/MAPK14/PIK3CB/PTPN6/MAPK1/PPP3R1/RASGRP1/IKBKB/MAP2K1/MTOR/LAT/RPS6KB2/TRAF6/MAP2K6/NFKBIE	2.25398240093288
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	30/1655	119/9376	1.42821599939069	MMP9/CASP3/ITCH/MAP3K8/NFKB1/PIK3R1/MAP2K4/CASP8/RPS6KA5/MAPK14/PIK3CB/MLKL/MAPK8/MAPK1/CSF1/DNM1L/TNFRSF1B/CREB1/CASP10/TRAF5/MAP3K7/TAB2/ATF6B/IKBKB/MAP2K1/BAG4/CYLD/FRMD8/MAP2K6/LIF	2.17645203036382
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/1655	68/9376	1.58293939932468	SOS1/LEF1/ITGAM/BRAF/KRAS/NFKB1/PIK3R1/SOS2/DUSP6/PIK3CB/PIM1/MAPK1/RUNX1/IKBKB/PML/MAP2K1/MTOR/RPS6KB2/CCNA2	2.23355956697321
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	21/1655	78/9376	1.52526144550314	ARPC5L/ACTB/HCLS1/ACTR2/SEPTIN6/PIK3R1/CTNNB1/ACTR3/PIK3CB/CBL/ARHGAP10/ARPC4/ELMO1/ARPC1B/ITGB1/ARPC2/CD2AP/ARPC3/SEPTIN11/GAB1/ACTR3C	2.15663135937367
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	37/1655	155/9376	1.35235162264886	LDLR/PRKACB/CDKN2A/LEF1/BRAF/GNAQ/CAMK2G/CDK6/CAMK2D/PLCB1/CTNNB1/RAP1A/WNT6/GSK3B/WNT4/ADCY7/GNAI2/MAPK1/ADCY9/ITPR1/KMT2A/RAP1B/CREB1/ARNT/ATF6B/USP8/MAP2K1/E2F3/ITPR2/RB1/PLCB2/ITPR3/SP1/CDKN1B/APC/ARMC5/CDK2	2.04786335622827
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	47/1655	205/9376	1.29886375359222	MMP9/CTSD/RAC2/REN/CAMK2G/NFKB1/PIK3R1/GFPT1/CAMK2D/PLCB1/GSK3B/MAPK14/G6PD/NDUFB3/COX8A/PIK3CB/MAPK8/NDUFS8/TBC1D4/UQCR11/PPP1CA/NDUFS6/TGFBR1/PARP1/GSR/MPC1/UQCR10/VDAC3/COX6B1/NDUFB9/NDUFB6/NDUFS7/COX7A2/COX5B/MTOR/NDUFA7/NCF1/PLCB2/UQCRQ/NDUFA13/NDUFAB1/PPP1CB/SP1/PDK3/NDUFC2/ATP5F1E/COX6A2	2.00304032025439
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	30/1655	122/9376	1.39309593383191	ATP1B3/PRKACB/NCOA1/KAT2B/NCOA2/ACTB/PLCG2/KRAS/PIK3R1/PLCB1/NCOR1/CTNNB1/MED14/NOTCH2/NCOA3/GSK3B/WNT4/PIK3CB/MED13L/EP300/TBC1D4/MAPK1/MED27/MAP2K1/RXRA/HDAC2/MTOR/PLCB2/ATP1B1/CASP9	2.02330605077091
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	42/1655	181/9376	1.31458997512978	PPP3CA/BCL2/CASP3/CTSD/ITGAM/CORO1A/SYK/FCER1G/LSP1/CAMK2G/NFKB1/MALT1/CAMK2D/CASP8/JAK2/ITGAX/PPP3CC/MAPK14/BAX/EP300/KSR1/IRAK4/MAPK8/MAPK1/PPP3R1/CALM3/ATP6V0A2/CREB1/CASP10/IL18/ATP6V0C/APAF1/TRAF6/ARHGEF12/BCL10/VDR/NFYC/NFYB/ATP6AP1/CASP9/RAB5B/RFXAP	1.97859159900614
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	14/1655	48/9376	1.65236656596173	HIBCH/OXCT1/BCKDHB/AUH/PCCA/ACAT2/ACADM/ACAA2/MCCC2/DBT/HIBADH/MCCC1/PCCB/ACADSB	2.09780881597263
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	25/1655	99/9376	1.43062040343007	PRKACB/PRKCH/PLCG2/GNAQ/CAMK2G/PIK3R1/CAMK2D/PLCB1/MAPK14/PIK3CB/ADCY7/MAPK8/CALM3/ADCY9/PPP1CA/ITPR1/TRPV2/ITPR2/PTGER4/PLCB2/ITPR3/PPP1CB/PTGER2/MAP2K6/HTR2B	1.9941429318872
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	13/1655	44/9376	1.67382587201318	FUT8/B4GALNT3/MAN1A1/MAGT1/B4GALT1/ST3GAL3/MAN1A2/STT3B/HEXD/ALG13/MGAT4A/STT3A/ALG9	2.07412304198825
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	8/1655	23/9376	1.97052410350716	IDI1/PDSS2/PDSS1/MVD/HMGCR/ACAT2/ZMPSTE24/DHDDS	2.15745942953279
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	23/1655	90/9376	1.44778784827123	PRKACB/KRAS/NFKB1/PIK3R1/ADIPOR2/SESN1/EHMT1/PIK3CB/BAX/ADCY7/ADCY9/CREB1/EIF4E/PRKAA1/RPTOR/ATF6B/FOXO3/MTOR/RPS6KB2/APPL1/EHMT2/ADIPOR1/PRKAB1	1.97618264029
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	26/1655	105/9376	1.40282549273486	BCL2/ZAP70/SYK/PLCG2/NFKB1/MALT1/LYN/TNFSF14/IRAK4/ERC1/PARP1/TRAF5/CARD11/MAP3K7/TRIM25/TAB2/IKBKB/BCL2L1/LAT/CYLD/TNFSF13B/TRAF6/BCL10/TNFSF11/CCL21/LY96	1.92174680196795
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	19/1655	72/9376	1.49499832158442	ISG15/IRF7/NFKB1/RNF125/ADAR/MAP3K1/CASP8/MAPK14/MAPK8/TBK1/CASP10/MAP3K7/TRIM25/IKBKB/IFIH1/ZNFX1/CYLD/TRAF6/DHX58	1.95201425439662
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	11/1655	36/9376	1.73105068815039	B4GALT5/GALNT1/GALNT10/GALNT3/GALNT11/GALNT2/ST3GAL1/C1GALT1/GALNT7/ST6GALNAC3/GALNT6	2.03457246921663
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	26/1655	106/9376	1.38959128997321	MMP9/BCL2/SOS1/LEF1/BRAF/GSTP1/KRAS/NFKB1/PIK3R1/CTNNB1/SOS2/GSK3B/PIK3CB/EP300/MAPK1/CREB1/IL1R2/IKBKB/MAP2K1/MTOR/E2F3/RB1/PDGFC/CDKN1B/CASP9/CDK2	1.86754108755566
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	71/1655	333/9376	1.20790760549069	ISG15/MX1/MAML3/ITGA1/PRKACB/EIF2AK2/PATJ/SOS1/CCND3/CASP3/PPP2R2B/DLG1/PPP2R5A/KRAS/NFKB1/PIK3R1/CDK6/ATR/IRF9/CTNNB1/CASP8/PPP2R5E/NOTCH2/SOS2/WNT6/GSK3B/ATP6V1A/WNT4/PIK3CB/PPP2R2A/BAX/EP300/MAPK1/RBPJ/ITGB1/UBE3A/IFNAR2/ATP6V0A2/ITGA4/TBK1/CREB1/HLA-A/RBL1/NFX1/LFNG/ATP6V0C/BCAP31/IKBKB/HES6/PPP2R3C/TBPL1/MAP2K1/HDAC2/MTOR/MAML2/RB1/RPS6KB2/PTGER4/THBS1/CDKN1B/TADA3/APC/TBP/ATP6AP1/ITGB5/HLA-C/ITGA3/VTN/CDK2/BAK1/CCNA2	1.78848000420429
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/1655	41/9376	1.65812394075602	MMP9/CDKN2A/BRAF/KRAS/RPS6KA5/MAPK1/DAPK2/MAP2K1/E2F3/RB1/THBS1/HBEGF	1.9551960797436
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	28/1655	116/9376	1.36747577872695	MMP9/VAV3/ITK/ACTB/ITGAM/TXK/PLCG2/RAC2/ACTN4/PECAM1/THY1/PIK3R1/CTNNB1/ITGAL/PTK2B/RAP1A/MAPK14/PIK3CB/GNAI2/MYL12A/ROCK1/ITGB1/CD99/RAP1B/ITGA4/MSN/NCF1/F11R	1.84374171249196
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	77/1655	368/9376	1.18539340601603	PPP3CA/BCL2/PFN1/CASP3/ACTB/RANBP2/NUP210/ERN1/ANXA11/PPP3CC/MAPK14/NDUFB3/COX8A/BAX/POM121/NDUFS8/PPP3R1/UQCR11/SPG11/PSMA4/NUP214/NDUFS6/NUP50/ATXN2/SETX/TNFRSF1B/NUP160/DNAH14/TBK1/ATF6/NUP54/UQCR10/COX6B1/UBQLN1/NDUFB9/NDUFB6/PSMD1/NDUFS7/NUP107/NUP155/COX7A2/DAXX/APAF1/CHCHD10/COX5B/NUP133/BCL2L1/KLC1/NUP43/MTOR/NDUFA7/DERL1/ALYREF/UQCRQ/NUP205/FIG4/RAB8A/NDUFA13/ATG2B/NDUFAB1/CASP1/ITPR3/POM121C/MCU/TOMM40/NCBP1/VAPB/NDUFC2/ATP5F1E/CASP9/ALS2/TUBA1B/ACTR1A/COX6A2/NUP37/MAP2K6/GLE1	1.67977790677121
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	26/1655	109/9376	1.35134565813908	PPP3CA/ZAP70/NFKB1/IL2RB/GATA3/NFATC3/JAK2/CD247/PPP3CC/MAPK14/MAPK8/MAPK1/PPP3R1/RUNX1/IL2RG/TGFBR1/SMAD4/IKBKB/RXRA/MTOR/LAT/IL21R/JAK3/IL27RA/IL4R/NFKBIE	1.70815044906491
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	20/1655	80/9376	1.41631419939577	BCL2/SOS1/BRAF/PLCG2/KRAS/PIK3R1/JAK2/SOS2/GSK3B/PIK3CB/BAX/MAPK1/EIF4E/FOXO3/MAP2K1/BCL2L1/MTOR/RPS6KB2/PDGFC/GAB1	1.73127485263666
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	14/1655	52/9376	1.52526144550314	APOA1/LDLR/STARD3NL/SOAT1/TSPO/APOC2/VAPA/VDAC3/NPC2/APOC1/SORT1/STARD3/VAPB/APOC3	1.75842530497113
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1655	34/9376	1.66625199928914	CUL1/CLOCK/RBX1/CREB1/PRKAA1/BTRC/FBXW11/CSNK1E/PER3/PRKAB1	1.8017972234553
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	25/1655	105/9376	1.34887066609121	RRAS2/KRAS/USP15/HUWE1/MAPK8/SMURF2/MFN1/CCZ1B/GABARAPL1/TBK1/MON1B/TAX1BP1/MTX2/USP8/RHOT1/CCZ1/FOXO3/BCL2L1/SMURF1/OPA1/SP1/TOMM40/FKBP8/RAB5B/FUNDC1	1.66434622175836
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	27/1655	115/9376	1.33010376986733	KCNQ5/PRKACB/BCL2/GNAQ/KRAS/CAMK2G/PIK3R1/FYN/CAMK2D/PLCB1/JAK2/PIK3CB/ADCY7/GNAI2/MAPK1/ADCY9/ITPR1/CREB1/PIK3CG/MAP2K1/ITPR2/PLCB2/ITPR3/GNB1/CHRM5/PIK3R5/GNGT2	1.64899114387303
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	38/1655	170/9376	1.26635151945975	PRKACB/PATJ/ARPC5L/ACTB/PPP2R2B/TIAM1/DLG1/RAPGEF6/RAB8B/HCLS1/ACTR2/ACTN4/WAS/MAP3K1/ACTR3/HSPA4/RAP1A/PPP2R2A/MYL12A/MAPK8/ROCK1/ARPC4/RUNX1/ARPC1B/ITGB1/ARPC2/PCNA/PRKAA1/ARHGAP17/SYMPK/MSN/ARPC3/RAB8A/F11R/NF2/TUBA1B/PRKAB1/ACTR3C	1.62252730856617
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	46/1655	212/9376	1.22925383343784	SKAP1/VAV3/PRKD3/FYB1/LCP2/PFN1/ACTB/ITGAM/BRAF/TIAM1/EVL/RAPGEF6/RAC2/SIPA1L1/GNAQ/KRAS/PIK3R1/PLCB1/CTNNB1/ITGAL/RAP1A/MAPK14/PRKD2/PIK3CB/LPAR3/ADCY7/RASGRP2/GNAI2/MAPK1/CALM3/ADCY9/TLN1/CSF1/ITGB1/RASGRP3/RAP1B/MAP2K1/LAT/PLCB2/THBS1/PDGFC/RGS14/TLN2/CNR1/MAP2K6/EFNA5	1.56311113785134
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	16/1655	63/9376	1.43879537716396	SMYD3/SETD2/KMT2C/NSD2/ASH1L/EHMT1/KMT2E/CAMKMT/PRDM2/NSD1/KMT2A/ACAT2/NSD3/KMT5A/SETDB1/EHMT2	1.61783928824738
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	35/1655	157/9376	1.26295533704081	ATP8A1/VPS8/CASP3/XKR6/ADAM10/CD47/ATP11B/PECAM1/CAMK2G/CAMK2D/NFATC3/VPS41/JAK2/MAPK14/PTPN6/ELMO1/MAPK1/ATP11C/CREB1/ARNT/DNMT3A/MAP2K1/RXRA/ATP11A/PTGER4/THBS1/CASP1/VPS39/PTGER2/ANO5/ITGB5/RAB5B/ARG1/VPS33A/TGFBRAP1	1.53828841587941
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/1655	157/9376	1.26295533704081	CASP3/ITCH/NFKB1/PIK3R1/ERN1/CASP8/ADIPOR2/GSK3B/MAPK14/NDUFB3/COX8A/PIK3CB/BAX/MAPK8/NDUFS8/UQCR11/NDUFS6/PRKAA1/UQCR10/COX6B1/IKBKB/NDUFB9/NDUFB6/NDUFS7/COX7A2/RXRA/COX5B/NDUFA7/UQCRQ/NDUFA13/NDUFAB1/NDUFC2/ADIPOR1/PRKAB1/COX6A2	1.53828841587941
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	39/1655	178/9376	1.24126412980753	PRKACB/PPP3CA/CCND3/TBL1XR1/CUL1/LEF1/RAC2/INVS/LGR4/CAMK2G/CAMK2D/PLCB1/NLK/CTNNB1/NFATC3/WNT6/GSK3B/PPP3CC/WNT4/EP300/MAPK8/CACYBP/RBX1/CCDC88C/PPP3R1/SMAD4/CTBP2/MAP3K7/BTRC/RYK/TLE3/FBXW11/PLCB2/NKD1/APC/TLE1/CCAR2/CSNK1E/VANGL1	1.50454061881492
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1655	14/9376	2.02330599913681	FUT8/B3GNT7/B4GALT1/ST3GAL3/ST3GAL1	1.77391612157514
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	30/1655	133/9376	1.27787747313904	SOS1/BRAF/KRAS/PIK3R1/STK4/NLK/SOS2/MAPK14/PIK3CB/DEPP1/EP300/MAPK8/MAPK1/TGFBR1/SMAD4/GABARAPL1/SGK3/TNFSF10/PRKAA1/IKBKB/FOXO3/MAP2K1/AGAP2/CDKN1B/HOMER2/CSNK1E/PRKAB1/S1PR4/CDK2/CCNB1	1.49424064658438
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	40/1655	184/9376	1.23157756469197	PPP3CA/SSH2/PLCG2/SEMA3B/RAC2/SEMA3A/KRAS/CAMK2G/PIK3R1/FYN/CAMK2D/SRGAP2/SRGAP3/NFATC3/SEMA4D/GSK3B/PPP3CC/WNT4/PIK3CB/LIMK1/NCK1/GNAI2/MYL12A/ROCK1/MAPK1/PPP3R1/RASA1/CFL1/ITGB1/PAK2/PLXNC1/RYK/SSH1/ARHGEF12/EPHB3/ABLIM3/UNC5C/PAK1/SEMA3C/EFNA5	1.46875124313878
Organismal Systems	Endocrine system	hsa04924	Renin secretion	17/1655	69/9376	1.3957879066509	PRKACB/PPP3CA/REN/GNAQ/PLCB1/PPP3CC/GNAI2/PPP3R1/CALM3/ITPR1/CREB1/ITPR2/PTGER4/PLCB2/ITPR3/KCNMA1/PTGER2	1.52767182720238
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	43/1655	201/9376	1.21197035968195	MMP9/FUT8/FLI1/ITGAM/NSD2/PBX3/TAF15/NFKB1/IL2RB/NCOR1/GZMB/DUSP6/IGFBP3/BAX/CCNT1/CCNT2/JMJD1C/RUNX1/SUPT3H/KMT2A/REL/IL1R2/PML/BMP2K/ELK4/POLK/MLLT3/RXRA/HDAC2/DDB2/BCL2L1/SP1/CDKN1B/ETV6/RUNX2/SS18L1/CDK9/PRCC/SIX4/HPGD/HOXA9/BAK1/CCNA2	1.40642957392704
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	31/1655	140/9376	1.25444971946482	MEF2A/PRKACB/RRAS2/SERPINE1/GNAQ/KRAS/PLCB1/ADCY7/GNAI2/MAPK1/CALM3/ADCY9/PLIN1/ITPR1/NRF1/TGFBR1/SMAD4/PIK3CG/GNA13/PRKAA1/MAP2K1/MTOR/ITPR2/RPS6KB2/PLCB2/ITPR3/TFAM/GNB1/PIK3R5/PRKAB1/GNGT2	1.40433879401737
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	14/1655	56/9376	1.41631419939577	MGAT5/FUT8/MAN1A1/MAGT1/B4GALT1/MAN1A2/STT3B/MOGS/ALG13/MGAT4A/ALG6/STT3A/GANAB/ALG9	1.44662225534215
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	8/1655	28/9376	1.61864479930945	THEM4/ELOVL5/HACD2/ACAA2/HACD1/ELOVL6/HACD4/ACOT4	1.51778022861101
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	17/1655	71/9376	1.35646993744947	CASP3/ADAM10/PLCG2/NFKB1/MAP2K4/LYN/ATP6V1A/MAPK14/MAPK8/ATP6V0A2/ATP6V0C/IKBKB/HBEGF/F11R/NOD1/ATP6AP1/PAK1	1.39585966047287
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	36/1655	168/9376	1.21398359948209	PRL/STAT4/BCL2/SOS1/CCND3/STAM/PIAS1/OSM/PIK3R1/IL2RB/IRF9/PRLR/JAK2/SOS2/PIK3CB/EP300/PTPN6/PIM1/IL2RG/IFNAR2/PTPN2/SOCS1/STAM2/BCL2L1/MTOR/SOCS2/IL21R/JAK3/SOCS4/IL27RA/PIAS2/SOCS7/CISH/IL4R/LIF/IFNL1	1.29568769762964
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	61/1655	300/9376	1.15193554884189	RASA2/AREG/PPM1B/RPS6KA3/PRKACB/PPP3CA/SOS1/RRAS2/CASP3/BRAF/TAOK3/RAC2/MAP3K8/KRAS/NFKB1/STK4/MAP2K4/MAP3K1/NLK/NFATC3/RPS6KA5/SOS2/RAP1A/PTPN7/PPP3CC/MAPK14/DUSP6/TAOK1/RASGRP2/IRAK4/MAPK8/MAPK1/MAP4K3/PPP3R1/RASA1/CSF1/MAP3K21/PAK2/RASGRP3/TGFBR1/RAP1B/STMN1/MAP3K7/RASGRP1/TAB2/IKBKB/MAP2K5/ELK4/MAP2K1/DAXX/MAPK8IP3/TRAF6/MKNK1/PDGFC/EREG/RPS6KA1/PPP5C/MAP2K6/PAK1/MAP4K2/EFNA5	1.23828509030727
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	29/1655	133/9376	1.23528155736774	PRKACB/PPP3CA/PPP2R2B/PPP2R5A/GNAQ/CAMK2G/CLOCK/CAMK2D/PLCB1/PPP2R5E/GSK3B/MAOA/PPP3CC/MAPK14/PPP2R2A/GNAI2/MAPK8/CALM3/PPP1CA/ITPR1/CREB1/ATF6B/PPP2R3C/ITPR2/PLCB2/ITPR3/PPP1CB/GNB1/GNGT2	1.26518807890065
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	33/1655	154/9376	1.21398359948209	PRKACB/PPP3CA/ACTB/CD38/PPP1R12A/GNAQ/KRAS/CAMK2G/CAMK2D/PLCB1/NFATC3/PPP3CC/PPP1R12B/ADCY7/GNAI2/ROCK1/MAPK1/PPP3R1/CALM3/ADCY9/PPP1CA/ITPR1/PIK3CG/PRKAA1/MAP2K5/MAP2K1/ITPR2/PLCB2/ITPR3/PPP1CB/PIK3R5/EEF2K/PRKAB1	1.23958454009184
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	9/1655	34/9376	1.49962679936023	POLR2J/POLR2K/POLR3GL/POLR3K/POLR2J3/POLR2G/POLR2I/POLR2L/POLR3C	1.35117970499393
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	49/1655	238/9376	1.1663763995024	RASA2/PRKACB/SOS1/RRAS2/PLD1/ZAP70/TIAM1/PLCG2/RALGAPA1/RAC2/ARF6/KRAS/NFKB1/PIK3R1/STK4/SOS2/RAP1A/ETS2/PIK3CB/PLAAT2/KSR1/RASGRP2/MAPK8/MAPK1/RASA1/CALM3/CSF1/PAK2/RASGRP3/EXOC2/ETS1/RAP1B/TBK1/REL/RALBP1/RASGRP1/IKBKB/MAP2K1/RALGAPB/PLAAT3/BCL2L1/LAT/PDGFC/GNB1/GAB1/RAB5B/PAK1/GNGT2/EFNA5	1.20365627515638
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	30/1655	139/9376	1.22271729444239	MMP9/PRKACB/NCOA1/BCL2/SOS1/NCOA2/FKBP5/CTSD/GNAQ/KRAS/PIK3R1/PLCB1/SOS2/NCOA3/PIK3CB/ADCY7/KRT23/GNAI2/MAPK1/CALM3/ADCY9/ITPR1/CREB1/ATF6B/MAP2K1/ITPR2/PLCB2/ITPR3/HBEGF/SP1	1.2247395188731
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	19/1655	83/9376	1.29686601390456	CASP3/IFI16/SAMHD1/IRF7/ZBP1/NFKB1/POLR2K/POLR3GL/ADAR/POLR3K/CASP8/MLKL/TBK1/IL18/PYCARD/IKBKB/CASP1/POLR2L/POLR3C	1.25767787173632
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	13/1655	54/9376	1.36385811793667	SMS/AHCYL2/DNMT1/MPST/DNMT3A/KYAT3/ENOPH1/GOT2/MTAP/DNMT3B/MAT2B/APIP/MRI1	1.2414300692681
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	20/1655	89/9376	1.27309141518721	PRKACB/SOS1/GNAQ/KRAS/PLCB1/SOS2/ADCY7/GNAI2/MAPK1/ADCY9/ITPR1/MAP2K5/MAP2K1/ITPR2/PLCB2/ITPR3/PDGFC/TUBA1B/CDK1/HTR2B	1.19843142807461
NA	NA	hsa04517	IgSF CAM signaling	60/1655	299/9376	1.13684082894644	CASK/VAV3/CABLES1/LCP2/NCAM1/CD96/ARPC5L/ACTB/IQGAP1/ITGAM/MBP/PLCG2/RAPGEF6/ARF6/ACTR2/ACTN4/DOK2/PIK3R1/FYN/SRGAP2/LYN/CTNNB1/ACTR3/LMO7/SRGAP3/ITGAL/ITGAX/RAP1A/GSK3B/NFASC/MAPK14/PIK3CB/SH2D1B/NCK1/PTPN6/MYL12A/ERC1/MAPK8/NECTIN3/ARPC4/MAPK1/RASA1/ARPC1B/MTSS1/ITGB1/PAK2/ARPC2/RAP1B/ITGA4/CD2AP/MAP2K1/MSN/ARPC3/CADM1/TRAF6/F11R/TUBA1B/UNC5C/ACTR3C/PAK1	1.1133404388382
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	15/1655	65/9376	1.3073669532884	AGPAT4/LCLAT1/DGKE/AGPAT5/LPIN1/DGKD/DGKZ/PLPP3/PLPP1/LPIN2/AKR1B1/AGK/GK/DGKQ/DGKB	1.15123384345777
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	26/1655	122/9376	1.20734980932098	PPP2R2B/PPP2R5A/PIK3R1/CAB39/ADIPOR2/PPP2R5E/PIK3CB/PPP2R2A/TBC1D1/CREB1/ACACA/MAP3K7/RAB10/PRKAA1/RPTOR/HMGCR/PPP2R3C/FOXO3/MTOR/ELAVL1/RPS6KB2/RAB8A/EEF2K/ADIPOR1/PRKAB1/CCNA2	1.0672512425548
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	23/1655	107/9376	1.21776547985431	PRKACB/PPP3CA/SIK2/GNAQ/CAMK2G/CAMK2D/PLCB1/PPP3CC/PHKB/EP300/PPP4R3A/PPP3R1/CALM3/ITPR1/CREB1/ACACA/PPP4C/PRKAA1/ITPR2/PLCB2/ITPR3/PHKA2/PRKAB1	1.04884749519796
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	27/1655	128/9376	1.19501510574018	PDE7A/ADK/GMPS/ADCY7/NT5C/ADCY9/NUDT16/PDE4A/NME7/NUDT2/AMPD3/HPRT1/NT5C2/PDE4B/AK2/AK3/GART/DCK/RRM1/PAPSS1/PPAT/IMPDH1/FHIT/NME1/AK9/RRM2B/PDE9A	1.02848316717082
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	18/1655	82/9376	1.24359295556702	KLRC3/KLRC1/KLRC2/KLRC4/KLRD1/KIR2DL4/HSPA4/TAPBP/PSME2/CREB1/HLA-A/NFYC/PSME3/NFYB/TAP2/HLA-C/KIR3DL1/RFXAP	1.0256948572052
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1655	32/9376	1.41631419939577	HIBCH/SUCLG2/ACACA/BCKDHB/PCCA/DBT/PCCB/ACSS1	1.09213835415226
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	41/1655	203/9376	1.14421442709806	VAV3/ITGA1/BCL2/SOS1/CCND3/ACTB/BRAF/RAC2/PPP1R12A/ACTN4/PIK3R1/FYN/CTNNB1/SOS2/RAP1A/GSK3B/DIAPH1/PIK3CB/PPP1R12B/MYL12A/MAPK8/ROCK1/MAPK1/TLN1/PPP1CA/PARVG/ITGB1/PAK2/RAP1B/ITGA4/PARVB/MAP2K1/ZYX/THBS1/PDGFC/PPP1CB/ITGB5/ITGA3/VTN/TLN2/PAK1	0.961720541446732
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	22/1655	103/9376	1.2100548499692	PPP2R2B/SERPINE1/GNAQ/NFKB1/PIK3R1/MAP2K4/PLCB1/CASP8/CD247/CCL3/MAPK14/PIK3CB/PPP2R2A/IRAK4/GNAI2/MAPK8/MAPK1/TGFBR1/IKBKB/GNA15/PLCB2/TRAF6	0.992405258751739
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/1655	98/9376	1.21398359948209	ATP1B3/LDLR/PRKACB/PRKD3/GNAQ/CAMK2G/CAMK2D/PLCB1/PRKD2/ADCY7/CALM3/ADCY9/ITPR1/CREB1/ATF6B/ATP2B1/ITPR2/PLCB2/ATP1B1/ITPR3/DAGLB	0.985857633257589
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/1655	18/9376	1.57368244377308	MANBA/FUCA1/HEXD/AGA/NEU3	1.12788326450644
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	18/1655	83/9376	1.22860990790958	AGPS/PEX14/ECI2/SLC27A2/NUDT19/FAR1/ACSL5/SLC25A17/PEX2/PEX1/GNPAT/FAR2/PEX3/IDH1/PEX11B/PECR/PEX11A/CROT	0.968509728196756
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	23/1655	109/9376	1.19542115912304	MAP3K8/IRF7/NFKB1/PIK3R1/MAP2K4/IRF9/CASP8/CCL3/MAPK14/PIK3CB/IRAK4/MAPK8/MAPK1/IFNAR2/TBK1/MAP3K7/TAB2/IKBKB/CTSK/MAP2K1/TRAF6/MAP2K6/LY96	0.950086426230023
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	17/1655	78/9376	1.23473545588349	CASP3/ITGAM/NFKB1/MAPK14/SERPING1/IRAK4/GNAI2/MAPK8/MAPK1/CALM3/CFL1/ITGB1/PYCARD/TRAF6/CASP1/NOD1/LY96	0.963782607022107
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1655	28/9376	1.41631419939577	GCH1/MOCS2/PCBD1/AKR1B1/GPHN/DHFR/PCBD2	1.02138329044103
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	30/1655	148/9376	1.14836286437495	NCOA1/SOS1/LEF1/BRAF/KRAS/PIK3R1/CDK6/CTNNB1/NOTCH2/SOS2/NCOA3/WNT6/GSK3B/WNT4/PIK3CB/BAX/MAPK1/POLK/MAP2K1/DDB2/MTOR/E2F3/RB1/RPS6KB2/SP1/APC/BRCA2/TNFSF11/BRCA1/BAK1	0.842267678571754
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	28/1655	138/9376	1.14947239371251	ATP6V1A/PPA2/NDUFB3/COX8A/NDUFS8/UQCR11/NDUFS6/ATP6V0A2/ATP5MG/UQCR10/ATP6V0C/COX6B1/NDUFB9/NDUFB6/NDUFS7/COX7A2/COX5B/NDUFA7/ATP5MF/COX17/UQCRQ/NDUFA13/NDUFAB1/NDUFC2/ATP6AP1/ATP5F1E/COX6A2/COX10	0.81895382341087
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/1655	24/9376	1.41631419939577	XYLT1/HS2ST1/EXT2/B3GAT3/HS6ST2/HS6ST3	0.945414930436259
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	23/1655	112/9376	1.16340094950367	LDLR/BCL2/CASP3/NFKB1/CASP8/JAK2/MAPK14/IRAK4/GNAI2/MAPK8/MAPK1/ITGB1/PIK3CG/MAP3K7/SOCS1/TAB2/IKBKB/BCL2L1/TRAF6/PIK3R5/CASP9/MAP2K6/LY96	0.805401019491484
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/1655	70/9376	1.21398359948209	CASP3/ACTB/SNTB1/RAC2/PRF1/FYN/CASP8/ITGAL/EIF4G3/HLA-A/SNTB2/DAG1/SGCE/CASP9/HLA-C	0.831947355469927
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	29/1655	144/9376	1.14091977173548	CASP3/LEF1/NFKB1/MAP2K4/CTNNB1/LPIN1/CASP8/ADIPOR2/GSK3B/MAPK14/IRAK4/MAPK8/TRA2A/TBK1/TRA2B/ACACA/MAP3K7/PRKAA1/TAB2/IKBKB/ACADM/FOXO3/LPIN2/TRAF6/ADIPOR1/PRKAB1/IL17RA/MAP2K6/LY96	0.788956648318932
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	52/1655	268/9376	1.09922893087433	PRKACB/CASP3/NFE2L2/CAMK2G/CAMK2D/ERN1/UBE2J1/SLC39A11/MAOA/NDUFB3/COX8A/BAX/GNAI2/MAPK8/MFN1/NDUFS8/UQCR11/CALM3/UBE2G1/PSMA4/ITPR1/NDUFS6/SLC39A4/SLC39A10/ATF6/UQCR10/VDAC3/COX6B1/NDUFB9/NDUFB6/PSMD1/NDUFS7/COX7A2/DAXX/APAF1/COX5B/BCL2L1/KLC1/NDUFA7/ITPR2/SLC39A8/UQCRQ/NDUFA13/NDUFAB1/ITPR3/MCU/SLC39A9/NDUFC2/ATP5F1E/CASP9/TUBA1B/COX6A2	0.76303078324522
Organismal Systems	Nervous system	hsa04730	Long-term depression	13/1655	60/9376	1.227472306143	BRAF/GNAQ/KRAS/LYN/PLCB1/GNAI2/MAPK1/ITPR1/GNA13/MAP2K1/ITPR2/PLCB2/ITPR3	0.818346589590047
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	30/1655	150/9376	1.13305135951662	BCL2/SOS1/LEF1/BRAF/KRAS/PIK3R1/CTNNB1/SOS2/WNT6/GSK3B/WNT4/PIK3CB/BAX/ABCB1/MAPK1/TGFBR1/SMAD4/POLK/MAP2K1/RXRA/DDB2/MTOR/E2F3/RB1/RPS6KB2/CDKN1B/APC/GAB1/CDK2/BAK1	0.76051201897608
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	12/1655	55/9376	1.23605602856358	SGMS1/B4GALT5/B4GALT6/ASAH1/PLPP3/GALC/CERS6/PLPP1/SGPP1/ACER3/SGPL1/NEU3	0.812854937340787
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/1655	76/9376	1.19268564159644	ATP1B3/PRKACB/ACTB/GNAQ/CAMK2G/CAMK2D/PLCB1/ADCY7/GNAI2/CALM3/ADCY9/ITPR1/ITPR2/PLCB2/ATP1B1/ITPR3	0.780840869385866
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1655	15/9376	1.51073514602215	SLC33A1/ST3GAL1/ST3GAL5/ST6GALNAC3	0.916490806041332
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1655	30/9376	1.32189325276939	NFKB1/IKBKB/ABCC4/GART/DHFR/TYMS/MTHFR	0.817537106384912
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	17/1655	82/9376	1.17450445803552	GSTP1/DPYD/CDA/GMPS/MGST2/CMPK1/NME7/HPRT1/UCK2/TK2/RRM1/CDADC1/TPMT/IMPDH1/NME1/RRM2B/GSTA4	0.734784488121891
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/1655	56/9376	1.21398359948209	CASP3/ITGAM/NFKB1/CASP8/SAR1A/RAB1B/HSF1/IL18/PYCARD/APAF1/CASP1/CASP9	0.743557240512791
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/1655	51/9376	1.22191813281204	PLD1/SELENOI/AGPS/PLPP3/PLAAT2/ENPP6/PLPP1/PLAAT3/CEPT1/PAFAH2/LPCAT4	0.735700952791676
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	31/1655	158/9376	1.11153772610807	RPS6KA3/SOS1/BRAF/KRAS/PIK3R1/CAB39/RICTOR/LPIN1/FNIP1/SOS2/WNT6/GSK3B/ATP6V1A/WNT4/PIK3CB/DDIT4/MAPK1/EIF4E/SLC38A9/PRKAA1/MAPKAP1/RPTOR/DEPDC5/IKBKB/MAP2K1/LPIN2/MTOR/LAMTOR4/RPS6KB2/RPS6KA1/TTI1	0.654605784983788
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	13/1655	62/9376	1.18787642529968	PRKACB/KRAS/PIK3R1/PIK3CB/ADCY7/ADCY9/PRKAA1/RPTOR/FOXO3/HDAC2/MTOR/RPS6KB2/PRKAB1	0.687144187691269
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	22/1655	110/9376	1.13305135951662	BCL2/PLCG2/SERPINE1/CAMK2G/NFKB1/PIK3R1/CAMK2D/PIK3CB/EP300/RBX1/MAPK1/HKDC1/EIF4E/ARNT/PGK1/MAP2K1/CUL2/MTOR/RPS6KB2/EGLN1/MKNK1/CDKN1B	0.6498563578453
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/1655	31/9376	1.27925153493812	SRP54/SEC11A/IMMP1L/SRP19/TMEM208/IMMP2L/SEC61A2	0.720998936354527
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1655	73/9376	1.16409386251707	CDKN2A/BRAF/KRAS/PIK3R1/CDK6/PIK3CB/BAX/MAPK1/POLK/MAP2K1/DDB2/E2F3/RB1/PDGFC/BAK1	0.651613567533691
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	30/1655	154/9376	1.10362145407463	ATP1B3/PRKACB/BCL2/PPP2R2B/PPP2R5A/GNAQ/CAMK2G/TPM3/CAMK2D/PLCB1/RPS6KA5/PPP2R5E/MAPK14/PPP2R2A/ADCY7/GNAI2/MAPK1/CALM3/ADCY9/PPP1CA/CREM/CREB1/PIK3CG/ATF6B/ATP2B1/PPP2R3C/PLCB2/ATP1B1/PPP1CB/PIK3R5	0.600268211225666
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	10/1655	47/9376	1.2053737867198	PIK3R1/PIK3CB/MAPK8/MAPK1/HKDC1/SOCS1/IKBKB/MTOR/SOCS2/SOCS4	0.653467893149208
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	28/1655	144/9376	1.10157771064115	ATXN10/GNAQ/PIK3R1/PUM2/PLCB1/ERN1/PIK3CB/MAPK8/RBPJ/PSMA4/NOP56/ITPR1/ATXN2/AFG3L2/PUM1/VDAC3/PSMD1/TBPL1/MTOR/ITPR2/PLCB2/ATG2B/ITPR3/OPA1/SP1/MCU/DAB1/TBP	0.56869528771155
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	32/1655	166/9376	1.09209769591963	MEF2A/ATP1B3/PPP3CA/PPP1R12A/GNAQ/PLCB1/NFATC3/GTF2I/PPP3CC/ADCY7/GNAI2/ROCK1/MAPK1/PPP3R1/CALM3/ADCY9/PPP1CA/ITPR1/CREB1/PIK3CG/GNA13/VDAC3/ATF6B/ATP2B1/MAP2K1/ITPR2/PLCB2/ATP1B1/ITPR3/KCNMA1/PPP1CB/PIK3R5	0.554269339237646
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	20/1655	101/9376	1.12183302922437	PRKACB/LEF1/GNAQ/KRAS/CAMK2G/CAMK2D/PLCB1/CTNNB1/WNT6/GSK3B/WNT4/EP300/ADCY7/GNAI2/MAPK1/CALM3/ADCY9/CREB1/MAP2K1/PLCB2	0.569923587181362
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/1655	101/9376	1.12183302922437	BCL2/CASP3/PLCG2/SERPINE1/KRAS/NFKB1/PIK3R1/PLCB1/JAK2/MAPK14/DIAPH1/PIK3CB/BAX/MAPK8/PIM1/MAPK1/TGFBR1/SMAD4/PLCB2/CDKN1B	0.569923587181362
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/1655	227/9376	1.07315437134834	PRKD3/SOS1/PLD1/BRAF/NFE2L2/PTPN1/KRAS/NFKB1/PIK3R1/MAP2K4/SOS2/MGST2/MAPK14/PRKD2/NDUFB3/COX8A/PIK3CB/MAPK8/NDUFS8/MAPK1/UQCR11/NDUFS6/ARNT/UQCR10/VDAC3/COX6B1/IKBKB/NDUFB9/NDUFB6/NDUFS7/FOXO3/MAP2K1/COX7A2/COX5B/NDUFA7/NCF1/UQCRQ/NDUFA13/NDUFAB1/NDUFC2/ATP5F1E/COX6A2/GSTA4	0.516552250948418
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/1655	32/9376	1.2392749244713	ATG7/GABARAPL1/ATG16L1/ATG10/RPTOR/MTOR/ATG2B	0.627702160006231
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	72/1655	388/9376	1.05128476656181	EIF2AK2/PPP3CA/CASP3/BRAF/ADAM10/GNAQ/KRAS/NFKB1/PIK3R1/PLCB1/CTNNB1/ERN1/CASP8/SLC39A11/WNT6/GSK3B/PPP3CC/NDUFB3/COX8A/WNT4/PIK3CB/MAPK8/NDUFS8/MAPK1/PPP3R1/UQCR11/CALM3/PSMA4/CSF1/ITPR1/NDUFS6/SLC39A4/SLC39A10/ATF6/APH1B/PSENEN/UQCR10/VDAC3/COX6B1/IKBKB/NDUFB9/NDUFB6/PSMD1/NDUFS7/MAP2K1/COX7A2/APAF1/COX5B/KLC1/MTOR/NDUFA7/ITPR2/SLC39A8/PLCB2/UQCRQ/NDUFA13/ATG2B/NDUFAB1/ITPR3/PPID/MCU/APC/SLC39A9/APH1A/NDUFC2/CSNK1E/CHRM5/ATP5F1E/CASP9/TUBA1B/NCSTN/COX6A2	0.477661870504452
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1655	27/9376	1.25894595501846	ELOVL5/HACD2/HACD1/ELOVL6/HACD4/ACOT4	0.623815691073074
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	15/1655	75/9376	1.13305135951662	ATP1B3/PRKACB/GNAQ/PLCB1/TTF2/ADCY7/ADCY9/ITPR1/CREB1/GSR/ATF6B/ITPR2/PLCB2/ATP1B1/ITPR3	0.535590650358749
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	30/1655	157/9376	1.08253314603498	AREG/PATJ/CCND3/ACTB/PPP2R2B/LEF1/DLG1/SERPINE1/CTNNB1/WNT6/GSK3B/WNT4/PPP2R2A/PPP1CA/TGFBR1/SMAD4/YWHAZ/BTRC/YWHAH/FBXW11/LIMD1/PPP1CB/NKD1/APC/CSNK1E/NF2/BIRC5/MOB1B/CRB2/WWC1	0.482818808321025
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	19/1655	97/9376	1.10968947581524	PRKACB/GNAQ/CAMK2G/CAMK2D/PLCB1/RPS6KA5/NOS1AP/ADCY7/GNAI2/MAPK1/CALM3/ADCY9/ITPR1/CREB1/PLCB2/ITPR3/GNB1/PER3/GNGT2	0.502745395696412
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	14/1655	70/9376	1.13305135951662	NFKB1/ADIPOR2/JAK2/MAPK8/TNFRSF1B/PRKAA1/IKBKB/ACSL5/RXRA/MTOR/APPL1/ADIPOR1/PRKAB1/NFKBIE	0.517290703397073
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	25/1655	130/9376	1.08947246107367	MMP9/PRKACB/SOS1/KRAS/NFKB1/PIK3R1/MAP2K4/PLCB1/SOS2/MAPK14/PIK3CB/ADCY7/GNAI2/MAPK8/MAPK1/ADCY9/TGFBR1/CREB1/ATF6B/MAP2K1/GNA15/PLCB2/GNB1/GNGT2/RXFP1	0.47558919151303
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/1655	38/9376	1.19268564159644	PTPRC/ZAP70/IL2RG/DCLRE1C/JAK3/TAP2/RFXAP/UNG	0.551013295275127
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	67/1655	362/9376	1.04854200397256	PRL/AREG/ITGA1/BCL2/SOS1/PIK3AP1/CCND3/PPP2R2B/SYK/PPP2R5A/OSM/KRAS/NFKB1/PIK3R1/CDK6/IL2RB/PHLPP1/PRLR/PPP2R5E/JAK2/SOS2/GSK3B/PIK3CB/PPP2R2A/PKN2/LPAR3/DDIT4/MAPK1/CSF1/IL2RG/ITGB1/IFNAR2/ITGA4/CREB1/EIF4E/PIK3CG/THEM4/SGK3/YWHAZ/PRKAA1/RPTOR/YWHAH/ATF6B/IKBKB/PPP2R3C/FOXO3/MAP2K1/RXRA/BCL2L1/MTOR/RPS6KB2/THBS1/PDGFC/EREG/CDKN1B/JAK3/GNB1/PIK3R5/CASP9/ITGB5/ITGA3/VTN/CDK2/BRCA1/IL4R/GNGT2/EFNA5	0.43607488093955
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1655	65/9376	1.13305135951662	LDLR/PRKACB/GNAQ/PLCB1/ADCY7/ADCY9/ITPR1/CREB1/ATF6B/ITPR2/PLCB2/ITPR3/SP1	0.498339936531408
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1655	60/9376	1.13305135951662	PPP3CA/PLCG2/RAC2/KRAS/PIK3R1/PPP3CC/MAPK14/PIK3CB/MAPK1/PPP3R1/MAP2K1/CASP9	0.478661020969705
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	57/1655	308/9376	1.0484403813709	CASP3/POLR2J/GNAQ/HIP1/POLR2K/RCOR1/PLCB1/ERN1/CASP8/POLR2J3/NDUFB3/COX8A/BAX/EP300/MAPK8/NDUFS8/UQCR11/PSMA4/ITPR1/NDUFS6/NRF1/DNAH14/CREB1/AP2B1/POLR2G/UQCR10/VDAC3/COX6B1/NDUFB9/NDUFB6/PSMD1/HTT/NDUFS7/TBPL1/COX7A2/APAF1/HDAC2/COX5B/KLC1/MTOR/NDUFA7/POLR2I/PLCB2/UQCRQ/NDUFA13/ATG2B/NDUFAB1/SP1/TFAM/POLR2L/TBP/NDUFC2/ATP5F1E/CASP9/TUBA1B/ACTR1A/COX6A2	0.400198095214658
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1655	39/9376	1.16210395847858	AHCYL2/GART/DHFR/MTHFD2L/MTHFD1/TYMS/MAT2B/MTHFR	0.469645435012534
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/1655	94/9376	1.08483640804782	MMP9/USP25/CASP3/NFKB1/CASP8/GSK3B/MAPK14/MAPK8/MAPK1/ANAPC5/TBK1/TRAF5/MAP3K7/TAB2/IKBKB/ELAVL1/TRAF6/IL17RA	0.382713055963395
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1655	18/9376	1.25894595501846	LMBRD1/MMADHC/CD320/MMAB	0.509098391012445
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1655	29/9376	1.17212209605167	LIMD1/CSNK1E/NF2/MOB1B/PAK1/WWC1	0.429781151152236
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/1655	51/9376	1.11083466619276	PRKACB/ACTB/PLCG2/ATP6V1A/ADCY9/ATP6V0A2/ATP6V0C/ERO1A/ATP6AP1/SEC61A2	0.367438065953026
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/1655	57/9376	1.0932951714634	ACACA/ELOVL5/HACD2/ACAT2/ACSL5/ACADM/ACAA2/HACD1/ELOVL6/HACD4/ACADSB	0.327084376559653
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1655	30/9376	1.13305135951662	PIGK/PIGB/PIGF/PIGS/PIGU/GPLD1	0.337920793691574
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1655	69/9376	1.06736722273304	PRKACB/PPP3CA/CAMK2G/CAMK2D/MAOA/PPP3CC/PPP3R1/CALM3/PPP1CA/CREB1/ATF6B/HDAC2/PPP1CB	0.260025651407569
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1655	109/9376	1.03949666010699	RPS6KA3/PTPN1/NFKB1/PIK3R1/GFPT1/OGA/GSK3B/PIK3CB/MAPK8/TBC1D4/PPP1CA/SLC27A2/CREB1/PRKAA1/IKBKB/MTOR/RPS6KB2/PPP1CB/RPS6KA1/PRKAB1	0.192022403395141
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1655	53/9376	1.06891637690247	ATP1B3/PRKACB/GNAQ/PLCB1/ADCY9/AP2B1/ATP2B1/PLCB2/VDR/ATP1B1	0.232932662689917
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/1655	59/9376	1.05623431819346	GSTP1/SMS/MGST2/G6PD/GSR/RRM1/IDH1/CHAC2/RRM2B/GGT5/GSTA4	0.200602921241603
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	27/1655	149/9376	1.0265901579513	PRKACB/GNAQ/PLCB1/MAPK14/NDUFB3/ADCY7/GNAI2/MAPK8/NDUFS8/MAPK1/ADCY9/ITPR1/NDUFS6/NDUFB9/NDUFB6/NDUFS7/NDUFA7/ITPR2/PLCB2/NDUFA13/NDUFAB1/ITPR3/GNB1/NDUFC2/DAGLB/CNR1/GNGT2	0.151471753169993
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/1655	93/9376	1.03558457590228	ATP1B3/PRKACB/CD38/GNAQ/PLCB1/ADCY7/CALM3/ADCY9/ITPR1/VAMP2/LYZ/ATP2B1/ITPR2/PLCB2/ATP1B1/ITPR3/KCNMA1	0.159663981272472
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1655	20/9376	1.13305135951662	GMDS/CYB5R4/CMAS/TGDS	0.275763681791857
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1655	110/9376	1.03004669046965	CUL1/TFDP1/NCOR1/LEMD3/EP300/SMURF2/ROCK1/RBX1/MAPK1/TGFBR1/SMAD4/RBL1/ZFYVE16/HDAC2/RPS6KB2/SMURF1/SMAD5/THBS1/SP1/E2F5	0.146755605540987
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/1655	37/9376	1.07180534008329	GMDS/GFPT1/HKDC1/CMAS/GALE/TGDS/UXS1	0.202607388517222
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1655	116/9376	1.02560683404521	PRKACB/PPP3CA/PLD1/SLC38A1/GNAQ/PLCB1/PPP3CC/ADCY7/GNAI2/MAPK1/PPP3R1/ADCY9/ITPR1/GRK2/ITPR2/PLCB2/ITPR3/HOMER2/GNB1/SLC1A1/GNGT2	0.128477550867643
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	49/1655	275/9376	1.00944575666026	PRKACB/PPP3CA/NCAM1/CASP3/RAC2/PIK3R1/FYN/GSK3B/PPP3CC/MAPK14/NDUFB3/COX8A/PIK3CB/BAX/MAPK8/NDUFS8/STIP1/MAPK1/PPP3R1/UQCR11/PSMA4/ITPR1/NDUFS6/CREB1/UQCR10/VDAC3/COX6B1/ATF6B/NDUFB9/NDUFB6/PSMD1/NDUFS7/COX7A2/APAF1/COX5B/KLC1/NDUFA7/ITPR2/NCF1/UQCRQ/NDUFA13/NDUFAB1/ITPR3/MCU/NDUFC2/ATP5F1E/CASP9/TUBA1B/COX6A2	0.0736048452460763
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1655	21/9376	1.07909653287297	XYLT1/CHST12/CHSY1/B3GAT3	0.167993724794322
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1655	21/9376	1.07909653287297	DPYD/PANK3/PPCDC/COASY	0.167993724794322
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/1655	44/9376	1.03004669046965	PRKACB/ARHGDIB/ADCY9/VAMP2/CREB1/ARHGDIA/NSF/RAB5B	0.0924875930518931
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1655	33/9376	1.03004669046965	BCKDHB/DLAT/GOT2/IDH1/DBT/IDH3B	0.0800494402810779
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	25/1655	142/9376	0.997404365771669	MMP9/MEF2A/BCL2/ACTB/NFE2L2/GSTP1/RAC2/PECAM1/NFKB1/PIK3R1/MAP2K4/CTNNB1/MGST2/MAPK14/PIK3CB/MAPK8/CALM3/MAP3K7/PRKAA1/IL1R2/IKBKB/MAP2K5/NCF1/GSTA4/MAP2K6	-0.014429144764857
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	18/1655	102/9376	0.999751199573485	ATP1B3/PRSS3/CD38/GNAQ/CPB1/PLCB1/RAP1A/ADCY7/ADCY9/ITPR1/RAP1B/ATP2B1/ITPR2/PLCB2/RAB8A/ATP1B1/ITPR3/KCNMA1	-0.0011696758457486
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	27/1655	154/9376	0.993259308667164	TPK1/CMPK1/NME7/GCH1/MOCS2/PANK3/NADSYN1/AK2/AK3/VKORC1L1/CMPK2/GPHN/PPCDC/DHFR/MMAB/MTHFD2L/NME1/FECH/AK9/KYNU/MTHFD1/MAT2B/CPOX/COQ2/PNPO/COX10/COASY	-0.039048117640503
NA	NA	hsa04518	Integrin signaling	27/1655	154/9376	0.993259308667164	ITGAD/ITGA1/CCND3/ACTB/ITGAM/RAC2/ARHGEF6/ACTN4/PIK3R1/CTNNB1/ITGAL/ITGAX/FERMT3/GSK3B/PIK3CB/TLN1/PARVG/ITGB1/ITGA4/PARVB/MTOR/THBS1/PDGFC/ITGB5/ITGA3/VTN/TLN2	-0.039048117640503
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1655	10/9376	1.13305135951662	MPST/PAPSS1	0.194890244669226
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1655	45/9376	1.00715676401477	ABCB10/ABCB1/ABCC4/ABCA5/TAP2/ABCA7/ABCA3/ABCA2	0.0222795656767113
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	84/1655	480/9376	0.991419939577039	PPP3CA/BCL2/CASP3/BRAF/GNAQ/HIP1/KRAS/CAMK2G/NFKB1/CAMK2D/PLCB1/CTNNB1/ERN1/CASP8/UBE2J1/WNT6/GSK3B/PPP3CC/MAPK14/NDUFB3/COX8A/WNT4/BAX/MAPK8/MFN1/NDUFS8/MAPK1/PPP3R1/UQCR11/CALM3/UBE2G1/SPG11/PSMA4/CSF1/ITPR1/NDUFS6/ATXN2/TNFRSF1B/DNAH14/TBK1/ATF6/UQCR10/VDAC3/COX6B1/NDUFB9/NDUFB6/PSMD1/HTT/NDUFS7/MAP2K1/COX7A2/DAXX/APAF1/COX5B/BCL2L1/KLC1/MTOR/NDUFA7/ITPR2/DERL1/PLCB2/UQCRQ/FIG4/RAB8A/NDUFA13/ATG2B/NDUFAB1/ITPR3/PPID/MCU/APC/TOMM40/VAPB/NDUFC2/CSNK1E/CHRM5/ATP5F1E/CASP9/ALS2/TUBA1B/ACTR1A/COX6A2/MAP2K6/BAK1	-0.0893431867012145
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/1655	86/9376	0.988126185624956	ATP1B3/PRKACB/GNAQ/CAMK2G/CAMK2D/PLCB1/ADCY7/ADCY9/VAMP2/CREB1/ATF6B/PLCB2/ATP1B1/ITPR3/KCNMA1	-0.0512129136632077
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	11/1655	63/9376	0.989171821800221	LEF1/CTNNB1/WNT6/GSK3B/WNT4/BAX/POLK/DDB2/APC/SUFU/BAK1	-0.0399235111020806
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	29/1655	168/9376	0.977931232916127	STAT4/EIF2AK2/BCL2/ZBP1/CAMK2G/CAMK2D/IRF9/CASP8/JAK2/HMGB1/TNFRSF10A/BAX/MLKL/MAPK8/CHMP5/DNM1L/IFNAR2/PARP1/TRAF5/TNFSF10/PYCARD/VDAC3/GLUD1/CYLD/RNF31/CASP1/PPID/JAK3/SPATA2L	-0.133628138238796
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	23/1655	134/9376	0.972394823465753	PRKACB/PRKCH/BRAF/PPP1R12A/GNAQ/PLCB1/ARHGEF1/PPP1R12B/ADCY7/ROCK1/MAPK1/CALM3/ADCY9/PPP1CA/ITPR1/GNA13/MAP2K1/ITPR2/PLCB2/ARHGEF12/ITPR3/KCNMA1/PPP1CB	-0.14900738972065
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1655	23/9376	0.985262051753579	ASL/GLUD1/GOT2/ARG1	-0.0327622212589095
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1655	23/9376	0.985262051753579	LNPEP/REN/CTSA/PREP	-0.0327622212589095
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/1655	100/9376	0.963093655589124	XCL1/CCR1/XCL2/IL2RB/CCL3/TNFRSF10A/TNFSF14/CSF1/IL2RG/TNFRSF1B/CXCR3/IL18/TNFSF10/CCL8/CCL28/CCL23/CCL21	-0.171778387364438
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1655	65/9376	0.958735765744829	GNAQ/KRAS/PIK3R1/PLCB1/PIK3CB/MAPK1/ITPR1/MAP2K1/ITPR2/PLCB2/ITPR3	-0.15455397039495
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/1655	78/9376	0.944209466263847	ITGAM/NFKB1/JAK2/MAPK14/IRAK4/PTPN6/MAPK1/ITGB1/ITGA4/MAP3K7/TAB2/NCF1/TRAF6	-0.229066145329457
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1655	12/9376	0.944209466263847	VKORC1L1/COQ2	-0.0895299408926014
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1655	12/9376	0.944209466263847	NCAM1/CD46	-0.0895299408926014
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1655	43/9376	0.922251106583292	ECI2/ACAT2/ACSL5/ACADM/ACAA2/ECI1/ACADSB	-0.236573269747786
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1655	31/9376	0.913751096384368	PGP/PCCA/ACAT2/PCCB/ACSS1	-0.222685858405024
NA	NA	hsa04981	Folate transport and metabolism	5/1655	31/9376	0.913751096384368	ABCC4/DHFR/MTHFD1/TYMS/MTHFR	-0.222685858405024
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1655	19/9376	0.894514231197329	BCKDHB/DLAT/DBT	-0.213083695056266
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/1655	116/9376	0.927929992707574	HIBCH/SUCLG2/G6PD/ME2/HKDC1/PGP/PGK1/GLUD1/PCCA/ACAT2/ADPGK/DLAT/RPIA/GOT2/IDH1/IDH3B/PCCB/ACSS1/ME1	-0.361597923882162
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1655	38/9376	0.894514231197329	CD38/NT5C/NT5C2/NADSYN1/NNT/SIRT5	-0.30165226942195
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1655	38/9376	0.894514231197329	ATP1B3/KRAS/PIK3R1/PIK3CB/MAPK1/ATP1B1	-0.30165226942195
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	36/1655	217/9376	0.939858270566779	RPS6KA3/PRKACB/BCL2/SOS1/KPNA1/CCND3/KRAS/NFKB1/PIK3R1/JAK2/NOTCH2/SOS2/MGST2/PIK3CB/ADCY7/GNAI2/MAPK1/KPNA3/ADCY9/KPNB1/CREB1/ARNT/ATF6B/MAP2K1/RXRA/MTOR/RB1/RPS6KB2/VDR/KPNA6/RPS6KA1/TNFSF11/KPNA5/BIRC5/CDC6/GSTA4	-0.414982335877403
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/1655	45/9376	0.881262168512924	KLRC1/KLRD1/PRF1/GZMB/HLA-A/HLA-C/KIR3DL1	-0.369640148741383
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1655	27/9376	0.839297303345642	OXCT1/BDH1/ACAT2/L2HGDH	-0.387142034188553
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/1655	144/9376	0.90486740516952	ZFHX3/KRAS/PIK3R1/CTNNB1/JAK2/WNT6/JARID2/GSK3B/MAPK14/WNT4/PIK3CB/MAPK1/SMAD4/KAT6A/SMARCAD1/RIF1/MAP2K1/SMAD5/APC/SETDB1/JAK3/LIF/PCGF6	-0.532611515325358
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1655	59/9376	0.864191714885555	PRKACB/PIK3R1/PIK3CB/PLAAT2/ADCY7/GNAI2/ADCY9/PLIN1/PLAAT3	-0.48446464006281
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1655	47/9376	0.843761650703863	ME2/ACACA/ACAT2/DLAT/ACYP1/ACSS1/ME1	-0.497126466694355
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	18/1655	115/9376	0.886735846578221	PRKACB/CASP3/BRAF/GNAQ/KRAS/PLCB1/MAOA/GNAI2/MAPK1/ITPR1/MAP2K1/KCND2/ITPR2/PLCB2/ITPR3/GNB1/GNGT2/HTR2B	-0.56579658567926
Cellular Processes	Cell motility	hsa04814	Motor proteins	31/1655	194/9376	0.905272993428224	MYO1F/ACTB/MYO1E/STARD9/TPM3/CAPZA1/KIFAP3/KIF18A/MYO1G/MYL12A/KIF13B/DYNLRB1/DNAH14/CENPE/KIF21B/KIF21A/MYO18B/HOOK3/KIFC1/KLC1/KIF20B/MYO9A/KIF11/KIF22/MYO19/TUBA1B/KIF2C/ACTR1A/KIF3A/KIF4A/KIF18B	-0.61723976230253
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1655	35/9376	0.809322399654726	GMDS/HKDC1/ENOSF1/AKR1B1/TIGAR	-0.523220648689847
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1655	48/9376	0.826183282980866	ATP1B3/PIK3R1/PLCB1/PIK3CB/HKDC1/PLCB2/ATP1B1	-0.558940724972022
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1655	15/9376	0.755367573011077	TPK1/AK2	-0.438981675612352
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/1655	86/9376	0.856376027541629	ITGA1/ACTB/LEF1/SNTB1/CTNNB1/ITGB1/ITGA4/SNTB2/DAG1/SGCE/ITGB5/ITGA3/PKP2	-0.619464130830351
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	36/1655	226/9376	0.902430286340668	ATP1B3/VAV3/PRKACB/RRAS2/PLD1/BRAF/TIAM1/RAC2/PPP1R12A/CAMK2G/NFKB1/PIK3R1/CAMK2D/RAP1A/PIK3CB/EP300/ADCY7/GNAI2/MAPK8/ROCK1/MAPK1/CALM3/ADCY9/PPP1CA/PDE4A/RAP1B/CREB1/ATP2B1/PDE4B/MAP2K1/ABCC4/ATP1B1/PPP1CB/PTGER2/FXYD1/PAK1	-0.687395308958693
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/1655	49/9376	0.809322399654726	PRKACB/NFKB1/RGS9/MAOA/GNAI2/CREB1/ATF6B	-0.619547473688195
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/1655	87/9376	0.846532624926208	ATP1B3/TPM3/COX8A/UQCR11/ASPH/UQCR10/COX6B1/COX7A2/COX5B/UQCRQ/ATP1B1/COX6A2/SLC9A6	-0.665792764034759
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1655	23/9376	0.738946538815185	B4GALT1/ST3GAL3/FKTN	-0.580317633956834
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1655	23/9376	0.738946538815185	ATP1B3/GLUD1/ATP1B1	-0.580317633956834
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1655	30/9376	0.755367573011077	SUCLG2/DLAT/IDH1/IDH3B	-0.621311831695104
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1655	16/9376	0.708157099697885	MAOA/GOT2	-0.540902589565336
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1655	37/9376	0.765575242916633	GFPT1/ASL/GLUD1/GOT2/PPAT	-0.661457598854839
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1655	37/9376	0.765575242916633	APOA1/GNAQ/PLCB1/IL18/PLCB2	-0.661457598854839
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1655	71/9376	0.797923492617335	KRAS/PIK3R1/G6PD/PIK3CB/MAPK1/HKDC1/MAP2K1/MTOR/IDH1/TIGAR	-0.791288171459603
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1655	17/9376	0.666500799715657	KYAT3/PAPSS1	-0.637165709041828
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1655	17/9376	0.666500799715657	CA5B/GLUD1	-0.637165709041828
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1655	17/9376	0.666500799715657	DAG1/PCDH20	-0.637165709041828
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1655	32/9376	0.708157099697885	B4GALT1/HKDC1/AKR1B1/GALE	-0.765606422431843
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/1655	46/9376	0.738946538815185	PSME4/PSME2/PSMA4/PSMD1/PSMB10/PSME3	-0.821704018147786
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	15/1655	105/9376	0.809322399654726	ITGA1/PRKACB/ACTB/SNTB1/TPM3/ADCY7/TTN/ADCY9/ITGB1/ITGA4/SNTB2/DAG1/SGCE/ITGB5/ITGA3	-0.909659580337537
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1655	18/9376	0.629472977509231	ACACA/ACSL5	-0.728471355975546
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	14/1655	99/9376	0.80114742592084	ITGA1/ACTB/SNTB1/TPM3/TTN/ITGB1/ITGA4/PRKAA1/SNTB2/DAG1/SGCE/ITGB5/ITGA3/PRKAB1	-0.920858491443793
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1655	26/9376	0.653683476644202	APOA1/LMBRD1/SLC19A2	-0.818656930079653
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1655	61/9376	0.742984498043683	ATP1B3/SLC39A4/ATP2B1/SLC40A1/VDR/ATP1B1/ATP7A/SLC31A1	-0.932353633413696
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1655	19/9376	0.596342820798219	ARSB/GNS	-0.815396846954836
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/1655	42/9376	0.674435333045605	ATG7/VDAC3/ACSL5/SLC39A8/SLC40A1	-0.978984629861736
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/1655	103/9376	0.770034904525856	PRKACB/CASP3/ITGAM/ACTN4/GNAQ/NFKB1/PIK3R1/PLCB1/PIK3CB/IL1R2/GNA15/PLCB2/RAB5B/ARG1	-1.08647131980693
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1655	28/9376	0.606991799741044	ATP6V1A/ATP6V0A2/ATP6V0C	-0.96420446223886
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/1655	50/9376	0.67983081570997	SMS/MAOA/PYCR2/GOT2/SMOX/ARG1	-1.05090797354053
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/1655	50/9376	0.67983081570997	KLRB1/KLRK1/PECAM1/ITGAL/IL18/THBS1	-1.05090797354053
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1655	43/9376	0.658750790416637	APOA1/PLPP3/PLPP1/ACAT2/GOT2	-1.03834842866889
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1655	29/9376	0.586061048025836	RGS9/CALM3/GNB1	-1.03358699067201
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1655	52/9376	0.653683476644202	LDLR/PRKACB/ADCY7/ADCY9/ACOT4/HSD17B7	-1.15936881225908
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1655	22/9376	0.515023345234826	MAOA/CARNMT1	-1.05434162395095
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/1655	38/9376	0.596342820798219	GFPT1/HKDC1/GALE/UXS1	-1.15431783411903
Genetic Information Processing	Transcription	hsa03040	Spliceosome	35/1655	243/9376	0.815983489363818	PRPF38B/SF3B2/LSM6/DDX46/THOC2/RBM25/TRA2A/TXNL4A/ACIN1/LSM5/TRA2B/SF3A1/RP9/CDC40/PRPF40A/U2SURP/SRSF9/SRSF4/DHX15/AQR/BUD13/SNRPB2/ALYREF/SNRPD3/SRSF10/MAGOH/U2AF1/PRPF3/DDX42/NCBP1/SNRPD1/SNRNP40/U2AF1L4/PLRG1/SF3A2	-1.34555377886594
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1655	46/9376	0.615788782345987	MMAB/FECH/CPOX/FXN/COX10	-1.20936110148046
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/1655	95/9376	0.715611384957863	ACP5/ITGAL/ATP6V1A/CCL3/CSF1/ATP6V0A2/IL18/ATP6V0C/CTSK/TNFSF13B/TNFSF11/ATP6AP1	-1.28980626938114
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1655	31/9376	0.548250657830621	HIBCH/DPYD/SMOX	-1.16637065316458
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/1655	75/9376	0.67983081570997	ASL/PGK1/PYCR2/RPIA/GOT2/IDH1/IDH3B/MAT2B/ARG1	-1.28882276935556
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/1655	155/9376	0.767550920962869	ACTB/ITGAM/CORO1A/PIKFYVE/ATP6V1A/ITGB1/ATP6V0A2/HLA-A/MSR1/ATP6V0C/STX7/NCF1/THBS1/STX12/TAP2/ATP6AP1/ITGB5/HLA-C/TUBA1B/RAB5B/SEC61A2	-1.35099122737269
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1655	39/9376	0.58105197923929	PRF1/GZMB/HLA-A/HLA-C	-1.21377064017719
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/1655	89/9376	0.700200278352965	PRKACB/SLC38A1/ADCY7/GNAI2/ADCY9/GABARAPL1/NSF/GPHN/GNB1/TRAK2/GNGT2	-1.31563787277431
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	33/1655	233/9376	0.802375426267132	FBN2/ATP1B3/ITGA1/ACTB/SNTB1/FMNL1/LMNB1/TPM3/CAPZA1/FMNL3/DIAPH1/TTN/TLN1/FMNL2/ITGB1/LBR/NID2/ITGA4/PDLIM5/AMPD3/SNTB2/ZYX/SUN2/DAG1/SGCE/ATP1B1/THBS1/DIAPH3/ITGB5/ITGA3/PKP2/TLN2/SYNE3	-1.41423769215504
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1655	76/9376	0.670885673397996	APOA1/SLC27A2/PLIN1/ACSL5/ACADM/RXRA/GK/APOC3/ME1	-1.33370558793107
NA	NA	hsa04519	Cadherin signaling	60/1655	404/9376	0.841374771918279	VAV3/ARPC5L/RRAS2/MYO1F/ACTB/LEF1/KRT86/ADAM10/CYFIP2/MYO1E/TAOK3/EVL/RAC2/KRT81/ACTR2/ACTN4/KRAS/NFKB1/CTNNB1/ACTR3/PTK2B/WNT6/GSK3B/TMC6/TMC8/MAPK14/WNT4/MYO1G/TAOK1/NCKAP1L/EP300/KRT23/MAPK8/ROCK1/ARPC4/MAPK1/ARPC1B/PPP1CA/ARPC2/YWHAZ/APH1B/PSENEN/YWHAH/IKBKB/MAP2K1/RYK/ARPC3/LIMD1/PCDH20/PPP1CB/APC/APH1A/NF2/NCSTN/MOB1B/PKP2/ACTR3C/LHFPL5/WWC1/VANGL1	-1.50891984625817
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1655	79/9376	0.6454090022563	STX3/ATP6V1A/VAMP2/ATP6V0A2/AP2B1/STX2/ATP6V0C/NSF/SLC1A1	-1.46527013130148
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1655	42/9376	0.539548266436484	MAOA/KYAT3/ACAT2/KYNU	-1.38459487686057
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1655	16/9376	0.354078549848943	ST3GAL1	-1.19715293632577
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1655	26/9376	0.435788984429468	PLAAT2/PLAAT3	-1.33373728012843
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	26/1655	195/9376	0.755367573011077	HDAC9/ACTB/ITGAM/SYK/PLCG2/RAC2/NFKB1/PIK3R1/PLCB1/ITGAL/HMGB1/SELPLG/MAPK14/PIK3CB/MAPK1/HAT1/ATG7/HDAC8/MAP3K7/VDAC3/MAP2K1/HDAC2/MTOR/NCF1/PLCB2/CASP1	-1.59821129996358
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/1655	66/9376	0.60086056944063	STAT4/NFKB1/GATA3/IL2RG/IL18/IL21R/IL4R	-1.50650168479173
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1655	17/9376	0.333250399857828	GGT5	-1.27385607331511
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/1655	44/9376	0.515023345234826	PRF1/GZMB/HLA-A/HLA-C	-1.49282076609719
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/1655	89/9376	0.636545707593605	ITGA1/CD47/ITGB1/ITGA4/DAG1/THBS1/ITGB5/ITGA3/VTN/HMMR	-1.59497890620197
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1655	36/9376	0.472104733131923	DCXR/AKR1B1/CRYL1	-1.46917470157501
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1655	36/9376	0.472104733131923	HKDC1/AGL/GYG1	-1.46917470157501
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1655	90/9376	0.629472977509231	ATP1B3/LDLR/PRKACB/ADCY7/ABCB1/ADCY9/HMGCR/RXRA/ABCC4/ATP1B1	-1.63521424806748
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1655	28/9376	0.404661199827363	B4GALT1/ST3GAL3	-1.46060140040883
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/1655	91/9376	0.622555692042097	PDE7A/PRKACB/ADCY7/GNAI2/ADCY9/PDE4A/GRK2/PDE4B/GNB1/GNGT2	-1.67506044596752
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1655	63/9376	0.539548266436484	LTC4S/PLAAT2/TBXAS1/PLAAT3/GGT5/HPGD	-1.69768631045154
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1655	30/9376	0.377683786505539	PLAAT2/PLAAT3	-1.58054445708178
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1655	31/9376	0.365500438553747	G6PD/RPIA	-1.63821305054435
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/1655	88/9376	0.579401263389179	ITGAM/CLU/SERPINE1/ITGAX/SERPING1/CD46/PLAUR/CFH/VTN	-1.83525348553866
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	33/1655	254/9376	0.736037300473392	PRKACB/PPP3CA/ORAI2/STIM1/PLCG2/CD38/GNAQ/CAMK2G/STIM2/CAMK2D/PLCB1/NFATC3/PTK2B/PPP3CC/PHKB/ADCY7/PPP3R1/CALM3/ADCY9/ITPR1/ASPH/CYSLTR1/VDAC3/ATP2B1/GNA15/ITPR2/PLCB2/ITPR3/PDGFC/MCU/CHRM5/PHKA2/HTR2B	-1.9745232258035
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/1655	100/9376	0.566525679758308	ITGA1/ITGAM/CD37/CD7/CD38/CSF1/ITGA4/IL1R2/ITGA3/IL4R	-2.01758046979778
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1655	70/9376	0.485593439792836	GSTP1/MGST2/CYP3A5/HSD11B1/SULT1A1/GSTA4	-1.99996251318575
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/1655	160/9376	0.637341389728097	PTPRC/NCAM1/CD58/ITGAM/GLG1/PECAM1/SPN/ITGAL/SELPLG/NFASC/NECTIN3/ITGB1/CD99/ITGA4/HLA-A/CADM1/F11R/HLA-C	-2.14207470245826
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1655	54/9376	0.419648651672821	PRF1/GZMB/HLA-A/HLA-C	-1.98007294337473
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	29/1655	238/9376	0.690304399705502	ISG15/MX1/EIF2AK2/SYK/PLCG2/RPL36AL/NFKB1/PIK3R1/ADAR/IRF9/OAS2/OAS1/MAPK14/PIK3CB/IRAK4/MAPK8/MAPK1/IFNAR2/TBK1/OAS3/MAP3K7/RPL35/TAB2/IKBKB/IFIH1/TRAF6/RPS27L/CASP1/HBEGF	-2.24050438522334
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1655	37/9376	0.306230097166653	MAOA/GOT2	-1.95755507991293
NA	NA	hsa03272	Virion - Hepatitis viruses	3/1655	48/9376	0.354078549848943	LDLR/PDCD6IP/TSG101	-2.07708331979754
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	41/1655	323/9376	0.719119283903735	MMP9/BCL2/CDKN2A/SOS1/CASP3/PLCG2/SPRY2/KRAS/NFKB1/PIK3R1/CDK6/RPS6KA5/NOTCH2/SOS2/PIK3CB/EP300/DDIT4/ABCB1/ROCK1/PIM1/MAPK1/STMN1/DICER1/DNMT1/DNMT3A/SOCS1/CCNG1/RPTOR/IKBKB/MAP2K1/HDAC2/MTOR/E2F3/THBS1/CDKN1B/APC/DNMT3B/CDCA5/BRCA1/BAK1/EFNA5	-2.37834463075795
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	37/1655	298/9376	0.703404367485148	PRL/IL1RL1/TNFRSF18/XCL1/CCR1/XCL2/TNFRSF4/OSM/IL2RB/PRLR/CCL3/TNFRSF10A/TNFSF14/CSF1/IL2RG/TGFBR1/IFNAR2/TNFRSF1B/CXCR3/IL18/TNFSF10/CCL8/IL1R2/CCL28/TNFSF13B/TNFRSF21/IL21R/RELL1/TNFSF12/TNFSF11/IL27RA/CCL23/IL17RA/CCL21/IL4R/LIF/IFNL1	-2.40893818278516
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/1655	67/9376	0.422780358028588	HKDC1/PGK1/ADPGK/DLAT/ACSS1	-2.19520381272846
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1655	50/9376	0.339915407854985	ITGA4/CCL28/TNFSF13B	-2.16663000417947
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1655	73/9376	0.38803128750569	GSTP1/MGST2/MAOA/CYP3A5/GSTA4	-2.43011597052224
Human Diseases	Immune disease	hsa05310	Asthma	1/1655	32/9376	0.177039274924471	FCER1G	-2.15891500486992
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1655	191/9376	0.593220607076762	PRKACB/SOS1/HDAC9/BRAF/KRAS/SOS2/MAOA/GNAI2/MAPK1/CALM3/PPP1CA/HAT1/CREB1/HDAC8/ATF6B/MAP2K1/HDAC2/PPP1CB/GNB1/GNGT2	-2.62956498547774
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1655	66/9376	0.343348896823217	CYP3A5/HSD17B11/HSD11B1/HSD17B7	-2.47844717288343
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1655	79/9376	0.358560556809056	GSTP1/MGST2/CYP3A5/HSD11B1/GSTA4	-2.65060890752138
NA	NA	hsa04081	Hormone signaling	22/1655	219/9376	0.569112555008346	PRL/PRKACB/GNAQ/PIK3R1/PLCB1/ADIPOR2/PRLR/JAK2/PIK3CB/ADCY7/GNAI2/ADCY9/SMAD4/GNA13/GNA15/PLCB2/SMAD5/SLC40A1/APPL1/GNB1/ADIPOR1/GNGT2	-2.98715082578957
Genetic Information Processing	Translation	hsa03010	Ribosome	22/1655	222/9376	0.561421844805531	RPL36AL/MRPL33/MRPL1/MRPS6/MRPL52/RPL35/MRPL42/MRPS28/MRPL44/MRPS31/MRPL16/MRPS35/MRPS34/MRPL12/MRPL28/RPS27L/MRPL13/MRPL47/MRPL38/MRPL35/MRPL39/MRPL48	-3.06172295746883
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/1655	103/9376	0.385017452262928	ATP1B3/COL14A1/PRSS3/CPB1/ATP1B1/SLC36A4/SLC1A1	-2.90548832604577
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1655	41/9376	0.138176995063002	MAOA	-2.5603580972149
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	16/1655	183/9376	0.495322998695789	XRN1/MDN1/RRP7A/NOP56/EFL1/WDR43/NOP10/XPO1/DROSHA/NAT10/WDR36/UTP4/RBM28/RPP38/HEATR1/POP1	-3.19196624271951
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1655	86/9376	0.263500316166655	PRKACB/PLCB1/PLCB2/ITPR3	-3.1765946080825
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/1655	99/9376	0.286124080686014	ITGAM/ITGAL/SELPLG/KRT23/CFH	-3.30585965598733
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1655	68/9376	0.166625199928914	CYP3A5/DHRS4L2	-3.19311451538448
NA	NA	hsa04082	Neuroactive ligand signaling	12/1655	199/9376	0.341623525482397	PRKACB/GNAQ/PLCB1/ADCY7/GNAI2/ADCY9/PLCB2/GNB1/CHRM5/SLC1A1/GNGT2/HTR2B	-4.34608621567196
NA	NA	hsa04382	Cornified envelope formation	12/1655	217/9376	0.313286090188926	PPP2R2B/KRT86/KRT81/PPP2R5A/PPP2R5E/PPP2R2A/KRT23/S100A11/PPP2R3C/S100A1/PKP2/BLMH	-4.73837624987697
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/1655	143/9376	0.158468721610716	ACTN4/TRIM21/SNRPD3/SNRPD1	-4.69477436613946
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	23/1655	370/9376	0.352164611741651	PRL/PRSS3/NR3C1/PRLR/LPAR3/TSPO/PTGDR/PGRMC2/NMUR1/CYSLTR1/UTS2/PAQR6/PTGER4/CHRNA5/PTGER2/CHRM5/LTB4R/S1PR4/GAL/CNR1/TMEM97/RXFP1/HTR2B	-5.88636813596648
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/1655	449/9376	0.100939987484777	NCALD/PRKACB/CAMK2G/CAMK2D/CALM3/GRK2/OR2Z1/GNB1	-9.03872027115538