category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	60/1011	227/9376	2.45127387286108	FOS/MGST3/PTPN1/FOXO3/NDUFA4L2/SLC25A5/NDUFB4/MAP2K4/NFKBIA/COX8A/AKT3/NDUFA7/MAPK8/RELA/NDUFA5/JUN/NDUFS8/NDUFS7/NFKB1/UQCRH/NFE2L2/BRAF/EPHX1/ATP5F1B/NDUFB9/PRKD3/MAP2K1/UQCRB/VDAC2/ARAF/ATP5MC2/BAD/MGST2/SLC25A4/GSTM4/SOS2/NDUFAB1/RAC1/PLD1/PIK3CA/MAP2K7/COX7B/UQCR10/COX7A2/NDUFS2/MAPK1/NDUFC2/KRAS/ATP5F1C/PRKD1/HRAS/CAT/COX6A1/NDUFB11/COX5A/COX4I2/UQCRC1/PTPRJ/NDUFB8/COX5B	7.69491337083208
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	73/1011	308/9376	2.19805515947949	POLR2J/POLR2I/CREB5/NDUFA4L2/ATG13/SLC25A5/TUBA1A/CREB1/HIP1/POLR2K/NDUFB4/KLC1/PSMC6/COX8A/NDUFA7/MAPK8/RB1CC1/CLTB/NDUFA5/CYCS/NDUFS8/NDUFS7/POLR2F/ERN1/HDAC2/TBPL1/PSMA2/UQCRH/ATP5F1B/NDUFB9/PSMB2/PSMD11/SEM1/HAP1/UQCRB/PSMD7/VDAC2/ACTR10/ATP5MC2/BBC3/BAX/SLC25A4/DCTN4/NDUFAB1/PSMB3/MAP2K7/ULK1/COX7B/UQCR10/COX7A2/NDUFS2/BDNF/NDUFC2/ATP5F1C/POLR2J3/POLR2G/COX6A1/NDUFB11/ATG2B/POLR2H/COX5A/PSMD1/AP2B1/ADRM1/COX4I2/UQCRC1/IFT57/MTOR/SIN3A/DCTN1/NDUFB8/COX5B/PIK3C3	7.43232444349904
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	38/1011	120/9376	2.9367622815694	FOXO3/BCL2/NGF/NFKBIA/MAPKAPK2/NTRK3/AKT3/MAPK8/IRS1/RELA/MAP3K3/RPS6KA3/JUN/RIPK2/ARHGDIA/RPS6KA5/NFKB1/MAP3K1/BRAF/MAP2K1/BAD/BAX/CRK/SOS2/SORT1/RAC1/FRS2/PIK3CA/ARHGDIB/MAP2K7/BDNF/MAPK1/KRAS/HRAS/NTF3/CAMK2D/GAB1/RAP1A	7.42306924857656
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	69/1011	300/9376	2.13301681503462	JUND/HSPA1B/FOS/NR4A1/RAPGEF2/HSPA1A/PDGFA/MEF2C/MAP3K20/NGF/MYC/DUSP8/NFATC1/MAP2K4/ANGPT2/MAP3K8/MAPKAPK2/GNG12/TGFBR1/AKT3/MAPK8/PGF/RELB/DUSP1/MAP2K3/RELA/MAP3K3/RPS6KA3/MAP4K3/JUN/IGF1R/RPS6KA5/NFKB1/RRAS2/TAB2/PRKACB/MAP3K1/RASGRP2/BRAF/MAP2K1/PAK1/PPP3CC/ARAF/IL1RAP/PAK2/PPM1A/CRK/SOS2/RAC1/CSF1/AREG/MAP2K7/STK3/BDNF/KITLG/MAPK1/MAX/KRAS/DUSP5/HRAS/NTF3/TGFB2/DDIT3/ANGPT1/NF1/RAP1A/EPHA2/GADD45B/PDGFC	6.93390651942737
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	42/1011	157/9376	2.48093897068552	FOS/NDUFA4L2/SOCS3/NDUFB4/COX8A/AKT3/NDUFA7/MAPK8/IRS1/RELA/NDUFA5/CYCS/IL6R/JUN/NDUFS8/NDUFS7/ERN1/NFKB1/UQCRH/NDUFB9/UQCRB/ADIPOR1/BAX/ITCH/NDUFAB1/RAC1/PIK3CA/GSK3A/COX7B/UQCR10/PRKAA1/COX7A2/NDUFS2/NDUFC2/COX6A1/NDUFB11/COX5A/DDIT3/COX4I2/UQCRC1/NDUFB8/COX5B	6.50538978988662
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	43/1011	163/9376	2.44651168435552	NFATC2/MMP9/FOS/CREB5/BCL2/MYC/CREB1/NFATC1/IRF7/MAP2K4/NFKBIA/SMAD4/STAT1/TGFBR1/AKT3/EGR3/MAPK8/MAP2K3/RELA/CYCS/ATP6AP1/JUN/IFIH1/NFKB1/TAB2/MAP3K1/BRAF/JAK1/MAP2K1/ARAF/BAD/BAX/SOS2/PIK3CA/MAP2K7/MAPK1/TRAF3/KRAS/HRAS/STAT6/ATF6B/TGFB2/YWHAQ	6.47654602317837
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	33/1011	110/9376	2.78219584569733	THBS1/ID1/ROCK1/ID3/LTBP1/MYC/SMURF1/SMAD4/TGFBR1/NBL1/SKIL/PPP2CA/CHRD/TGIF2/HDAC2/LRRC32/RPS6KB1/SKI/BMPR2/RBX1/PPP2R1A/FST/ACVR2A/SMAD7/MAPK1/ZFYVE16/INHBA/TGFB2/LEMD3/TGIF1/ZFYVE9/SIN3A/BAMBI	6.53632841457825
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	60/1011	275/9376	2.02341516050715	HSPA1B/RYR2/HSPA1A/CREB5/NDUFA4L2/SLC25A5/TUBA1A/CREB1/MCU/NDUFB4/KLC1/PSMC6/COX8A/NDUFA7/MAPK8/NDUFA5/CYCS/NDUFS8/NDUFS7/CAV2/PRKACB/PSMA2/UQCRH/ATP5F1B/NDUFB9/PSMB2/PSMD11/SEM1/PPP3CC/UQCRB/PSMD7/VDAC2/ATP5MC2/BAD/BAX/SLC25A4/NDUFAB1/RAC1/PSMB3/PIK3CA/COX7B/UQCR10/COX7A2/NDUFS2/MAPK1/NDUFC2/ATP5F1C/ATF6B/COX6A1/CAV1/NDUFB11/NOTCH1/COX5A/DDIT3/PSMD1/ADRM1/COX4I2/UQCRC1/NDUFB8/COX5B	5.98827697145437
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	77/1011	388/9376	1.84045601476542	WNT6/NDUFA4L2/ATG13/SLC25A5/TUBA1A/MCU/NDUFB4/ATF6/KLC1/PSMC6/COX8A/AKT3/NDUFA7/MAPK8/CSNK1E/RB1CC1/IRS1/RELA/ADAM10/NDUFA5/CYCS/EIF2AK2/NDUFS8/NDUFS7/ERN1/NFKB1/PSMA2/UQCRH/BRAF/ATP5F1B/NDUFB9/PSMB2/PSMD11/SEM1/MAP2K1/PPP3CC/UQCRB/PSMD7/VDAC2/ARAF/ATP5MC2/BAD/SLC25A4/BACE2/SLC39A9/NDUFAB1/PSMB3/PIK3CA/CSF1/MAP2K7/ULK1/COX7B/UQCR10/COX7A2/NDUFS2/MAPK1/NDUFC2/WNT4/KRAS/SLC39A4/ATP5F1C/HRAS/COX6A1/NDUFB11/ATG2B/COX5A/DDIT3/PSMD1/ADRM1/COX4I2/UQCRC1/PSENEN/APH1A/MTOR/NDUFB8/COX5B/PIK3C3	5.87797268884262
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	33/1011	119/9376	2.57177767249333	MMP9/JUNB/FOS/ICAM1/JAG1/CREB5/CREB1/SOCS3/MAP2K4/MAP3K8/NFKBIA/CCL2/IRF1/DNM1L/AKT3/MAPK8/CXCL2/MAP2K3/RELA/JUN/RPS6KA5/NFKB1/TAB2/TNFAIP3/MAP2K1/ITCH/PIK3CA/CSF1/MAP2K7/MAPK1/TRAF3/BCL3/ATF6B	5.99870779500817
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	27/1011	87/9376	2.87813363348	FOS/BCL2/MYC/SMAD4/TGFBR1/AKT3/MAPK8/CYCS/JUN/BRAF/RPS6KB1/PMAIP1/MAP2K1/ARAF/BAD/BBC3/BAX/SOS2/RAC1/PIK3CA/AREG/MAPK1/KRAS/HRAS/TGFB2/MTOR/GADD45B	6.1182874653638
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	88/1011	480/9376	1.70023079459281	WNT6/RYR2/BCL2/NDUFA4L2/ATG13/SLC25A5/TUBA1A/HIP1/MCU/UBE2J1/NDUFB4/ATF6/KLC1/PSMC6/MAP1LC3A/COX8A/NDUFA7/MAPK8/CSNK1E/MAP2K3/RB1CC1/RELA/NDUFA5/CYCS/NDUFS8/NDUFS7/UBE2L3/ERN1/NFKB1/PSMA2/UQCRH/BRAF/ATP5F1B/NDUFB9/PSMB2/PSMD11/UBE2J2/SEM1/MAP2K1/HAP1/PPP3CC/UQCRB/PSMD7/VDAC2/ARAF/ACTR10/ATP5MC2/BAD/BAX/SLC25A4/DCTN4/NDUFAB1/RAC1/PSMB3/CSF1/MAP2K7/ULK1/ATXN2L/C9orf72/COX7B/UQCR10/COX7A2/NDUFS2/BDNF/MAPK1/NDUFC2/WNT4/KRAS/ATP5F1C/HRAS/CAT/COX6A1/NDUFB11/ATG2B/COX5A/CAMK2D/DDIT3/PSMD1/ADRM1/COX4I2/UQCRC1/DERL1/IFT57/MTOR/DCTN1/NDUFB8/COX5B/PIK3C3	5.47510788321936
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	72/1011	368/9376	1.81447555154174	BCL2/NDUFA4L2/ATG13/TUBA1A/MCU/NDUFB4/ATF6/KLC1/PSMC6/MAP1LC3A/NUP54/COX8A/NDUFA7/MAP2K3/RB1CC1/NDUFA5/CYCS/NXT1/NDUFS8/NDUFS7/ERN1/PSMA2/UQCRH/ATP5F1B/NDUFB9/PSMB2/PSMD11/SEM1/HAP1/PPP3CC/UQCRB/PSMD7/ACTR10/ATP5MC2/BAD/BAX/DCTN4/NDUFAB1/RAC1/PSMB3/ULK1/ATXN2L/C9orf72/RANBP2/COX7B/UQCR10/ANXA11/COX7A2/NDUFS2/NDUFC2/NUP98/ATP5F1C/NUP160/CAT/COX6A1/NDUFB11/ATG2B/SEH1L/COX5A/PFN1/DDIT3/PSMD1/ADRM1/COX4I2/NUP214/UQCRC1/DERL1/MTOR/DCTN1/NDUFB8/COX5B/PIK3C3	5.54135554587437
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	57/1011	268/9376	1.97245227866602	NDUFA4L2/SLC25A5/TUBA1A/MCU/UBE2J1/NDUFB4/ATF6/KLC1/PSMC6/COX8A/NDUFA7/MAPK8/DUSP1/NDUFA5/CYCS/NDUFS8/NDUFS7/UBE2L3/ERN1/PRKACB/PSMA2/UQCRH/NFE2L2/ATP5F1B/NDUFB9/PSMB2/PSMD11/UBE2J2/SEM1/MAOA/UQCRB/PSMD7/VDAC2/ATP5MC2/BAX/SLC25A4/SLC39A9/NDUFAB1/PSMB3/COX7B/UQCR10/COX7A2/NDUFS2/NDUFC2/SLC39A4/ATP5F1C/COX6A1/NDUFB11/COX5A/CAMK2D/DDIT3/PSMD1/ADRM1/COX4I2/UQCRC1/NDUFB8/COX5B	5.61503448304661
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	47/1011	205/9376	2.12623097150853	MMP9/RYR2/NDUFA4L2/SLC25A5/CTSD/NDUFB4/COX8A/TGFBR1/AKT3/NDUFA7/MAPK8/IRS1/RELA/NDUFA5/NDUFS8/NDUFS7/TBC1D4/NFKB1/UQCRH/ATP5F1B/NDUFB9/UQCRB/VDAC2/ATP5MC2/PTPA/SLC25A4/NDUFAB1/RAC1/PIK3CA/COX7B/UQCR10/COX7A2/NDUFS2/NDUFC2/ATP5F1C/COX6A1/NDUFB11/TGFB2/COX5A/CAMK2D/COX4I2/UQCRC1/MPC2/MTOR/NDUFB8/COX5B/REN	5.66792759196729
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	52/1011	250/9376	1.92898911968348	HSPA1B/HSPA1A/RAB31/SMURF1/RAB11FIP1/RAB11B/TGFBR1/SMAP1/ARPC1A/PARD6G/PARD3/CLTB/CHMP5/ARF3/CYTH3/IGF1R/ARF5/SMAP2/CAV2/CAPZB/AGAP1/LDLR/CHMP1B/ASAP1/PIP5K1B/VPS26A/ASAP2/VPS4B/RABEP1/CBL/ITCH/TSG101/RAB22A/PLD1/NEDD4/EPN2/ARFGAP3/VPS29/HLA-E/EPN1/EPS15L1/HRAS/ZFYVE16/CAV1/ARFGEF1/AMPH/SH3GL1/AP2B1/ACAP2/WASHC2A/ZFYVE9/RAB11FIP3	5.17569461006423
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	24/1011	80/9376	2.78219584569733	PDGFA/FOXO3/BCL2/AKT3/GAS6/IL6R/IGF1R/EIF4E/BRAF/RPS6KB1/JAK1/MAP2K1/ARAF/BAD/BAX/SOS2/PIK3CA/MAPK1/KRAS/HRAS/NF1/GAB1/MTOR/PDGFC	5.56519781967448
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	22/1011	70/9376	2.91468136215911	ETS1/EPAS1/AKT3/JUN/BRAF/MAP2K1/PAK1/RBX1/ARAF/BAD/PAK2/CRK/SOS2/RAC1/PIK3CA/MAPK1/TFE3/KRAS/HRAS/TGFB2/GAB1/RAP1A	5.58974825524041
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	25/1011	86/9376	2.69592620707106	MYC/MAP2K4/AKT3/MAPK8/JUN/BRAF/RPS6KB1/MAP2K1/PAK1/CBL/ARAF/BAD/PAK2/NCK2/CRK/SOS2/PIK3CA/AREG/MAP2K7/MAPK1/KRAS/HRAS/CAMK2D/GAB1/MTOR	5.49258217723954
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	37/1011	156/9376	2.19959927971797	IRF9/YWHAH/MYC/MX1/IRF7/SOCS3/PPP2R2A/NFKBIA/STAT1/AKT3/IFIT1/RELA/CYCS/PPP2CA/EIF2AK2/PPP2R2D/NFKB1/LDLR/OAS2/BRAF/YWHAG/JAK1/MAP2K1/PPP2R1A/ARAF/BAD/BAX/EIF3E/SOS2/PIK3CA/PIAS1/MAPK1/TRAF3/KRAS/HRAS/CLDN4/YWHAQ	5.25244215605335
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	23/1011	77/9376	2.77015170783717	MYC/NFKBIA/SMAD4/TGFBR1/AKT3/RELA/RUNX1/HDAC2/NFKB1/BRAF/MAP2K1/CBL/ARAF/BAD/BAX/CRK/SOS2/PIK3CA/MAPK1/KRAS/HRAS/TGFB2/GADD45B	5.42208061698608
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	25/1011	90/9376	2.57610726453456	FOXO3/CREB5/ATG13/CREB1/AKT3/RB1CC1/IRS1/RELA/IGF1R/EIF4E/NFKB1/PRKACB/RPS6KB1/ADIPOR1/BAX/RHEB/PIK3CA/ULK1/PRKAA1/KRAS/HRAS/CAT/ATF6B/SESN2/MTOR	5.22301086391731
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	46/1011	224/9376	1.90447929913805	NFATC2/ZFP36/FOS/ICAM1/ETS1/B2M/CREB5/SLC25A5/MYC/CREB1/NFATC1/MAP2K4/NFKBIA/SMAD4/TGFBR1/AKT3/MAPK8/RELB/CCND3/RELA/MAP3K3/CRTC3/JUN/NFYB/NFKB1/DLG1/PRKACB/MAP3K1/TBPL1/ANAPC10/JAK1/MAP2K1/PPP3CC/VDAC2/BAX/SLC25A4/ETS2/PIK3CA/HLA-E/MAPK1/KRAS/HRAS/ATF6B/TGFB2/LTBR/VAC14	4.76313486427435
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	43/1011	205/9376	1.9452751441461	ISG15/ICAM1/IRF9/B2M/BCL2/MYC/IRF7/MAP2K4/NFKBIA/PSMC6/STAT1/AKT3/MAPK8/RELB/CCND3/MAP2K3/RELA/CYCS/EIF2AK2/JUN/HDAC2/TAPBP/NFKB1/CD58/TAB2/TNFAIP3/OAS2/PSMD11/SEM1/JAK1/PSMD7/BAX/RAC1/NEDD4/USP7/PIK3CA/MAP2K7/HLA-E/TRAF3/PSMD1/ADRM1/GADD45B/SIN3A	4.7572400396076
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	22/1011	77/9376	2.64971032923555	SMAD4/STAT1/TGFBR1/AKT3/MAPK8/RELA/NFKB1/BRAF/RPS6KB1/JAK1/MAP2K1/ARAF/BAD/BAX/RAC1/PLD1/PIK3CA/MAPK1/KRAS/TGFB2/MTOR/GADD45B	5.05316146643665
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	33/1011	142/9376	2.15522213399089	SMURF1/UBE2J1/UBE2E2/SOCS3/UBE2E1/UBA6/UBE2S/FBXW11/UBA2/UBE2N/UBE2D1/UBE2L3/UBE2D2/MAP3K1/SIAH1/ANAPC10/UBE2J2/RBX1/CBL/ITCH/HERC1/NEDD4/TRIM37/PIAS1/UBE2Q1/UBE4B/UBE2B/PIAS2/UBE3A/UBR5/UBE2H/WWP2/RCHY1	4.82217516238347
Human Diseases	Infectious disease: viral	hsa05162	Measles	32/1011	136/9376	2.18211438878222	HSPA1B/FOS/IRF9/HSPA1A/BCL2/ADAR/MX1/IRF7/NFKBIA/STAT1/AKT3/MAPK8/CCND3/RELA/CYCS/EIF2AK2/JUN/IFIH1/NFKB1/CD46/TAB2/TNFAIP3/OAS2/JAK1/BAD/BBC3/BAX/PIK3CA/RAB9A/TRAF3/MSN/RCHY1	4.82748814063146
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	47/1011	235/9376	1.85479723046489	CREB5/NDUFA4L2/CREB1/NDUFAF3/NDUFB4/COX8A/NDUFA7/MAP2K3/NDUFA5/RPS6KA3/NDUFS8/NDUFS7/PRKG1/PRKACB/UQCRH/RPS6KB1/COX19/ARID1A/ATP5F1B/NDUFB9/UQCRB/ATP5MC2/RHEB/SMARCC1/SOS2/NDUFAB1/FRS2/COX7B/UQCR10/PRKAA1/COX7A2/NDUFS2/NDUFC2/COX20/KRAS/ATP5F1C/HRAS/SMARCD1/COX6A1/NDUFB11/COX5A/COX4I2/UQCRC1/MTOR/PLIN1/NDUFB8/COX5B	4.61347770718421
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	20/1011	68/9376	2.72764298597777	PER2/MYC/PIM1/AKT3/RELA/RUNX1/RUNX1T1/NFKB1/BRAF/RPS6KB1/MAP2K1/ARAF/BAD/SOS2/PIK3CA/PPARD/MAPK1/KRAS/HRAS/MTOR	4.97059654606611
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	35/1011	157/9376	2.06744914223793	NFATC2/ETS1/FOXO3/SLC25A5/MYC/ZFP36L1/NFATC1/MCU/IGFBP3/MAPKAPK2/HIPK3/TGFBR1/AKT3/CCND3/MAP2K3/RELA/FBXW11/NFKB1/RRAS2/SERPINE1/HIPK2/MAP2K1/PPP3CC/VDAC2/RHEB/SLC25A4/HIPK1/PIK3CA/HLA-E/MAPK1/KRAS/HRAS/TGFB2/MTOR/GADD45B	4.68903370671882
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	65/1011	362/9376	1.66521850801406	PRL/THBS1/NR4A1/PDGFA/FOXO3/CREB5/BCL2/YWHAH/ITGA1/NGF/MYC/CREB1/ANGPT2/PPP2R2A/GNG12/AKT3/PGF/CCND3/IRS1/PKN2/RELA/PPP2CA/IL6R/SGK1/IGF1R/EIF4E/PHLPP1/PPP2R2D/NFKB1/PPP2R5E/YWHAG/RPS6KB1/GHR/JAK1/MAP2K1/GNG10/PPP2R1A/BAD/GNB2/RHEB/SOS2/RAC1/PIK3CA/CSF1/AREG/LAMA3/VTN/PPP2R3C/ITGA3/PRKAA1/BDNF/KITLG/LAMB2/MAPK1/KRAS/HRAS/ATF6B/NTF3/ANGPT1/YWHAQ/EPHA2/MTOR/PDGFC/OSMR/PRLR	4.48733068925384
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	42/1011	203/9376	1.91875575565333	THBS1/PPP1R12B/PDGFA/ROCK1/BCL2/ITGA1/AKT3/MAPK8/PGF/CCND3/PARVA/ILK/JUN/IGF1R/CAV2/EMP1/PIP5K1B/BRAF/MAP2K1/PAK1/BAD/PAK2/CRK/SOS2/ACTN4/RAC1/PPP1R12C/PIK3CA/ACTN1/LAMA3/VTN/ITGA3/MYL12A/LAMB2/MAPK1/MYL9/HRAS/CAV1/PPP1R12A/BCAR1/RAP1A/PDGFC	4.60066528939666
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	13/1011	34/9376	3.54593588177111	PER2/CREB1/PER1/CSNK1E/FBXW11/CRY1/NR1D2/RBX1/CRY2/CLOCK/PRKAA1/PER3/FBXL3	5.1700558227882
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	42/1011	205/9376	1.90003618730549	IRF9/CREB5/YWHAH/HDAC5/CREB1/IRF7/NFKBIA/MAPKAPK2/UBR4/EGR3/CCND3/RELA/EIF2AK2/JUN/GTF2B/HDAC2/NFKB1/DLG1/PRKACB/TBPL1/GTF2A2/YWHAG/JAK1/PMAIP1/BAD/BAX/ACTN4/RAC1/USP7/PIK3CA/ACTN1/HLA-E/MAPK1/TRAF3/KRAS/SP100/HRAS/ATF6B/UBE3A/LTBR/YWHAQ/VAC14	4.52956815151768
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	29/1011	122/9376	2.20447211817548	NFATC2/FOS/NFATC1/MAP3K8/PPP2R2A/NFKBIA/AKT3/MAPK8/RELA/PPP2CA/JUN/PPP2R2D/NFKB1/DLG1/PPP2R5E/MAP2K1/PAK1/PPP3CC/PPP2R1A/PAK2/NCK2/SOS2/PIK3CA/MAP2K7/PPP2R3C/MAPK1/KRAS/HRAS/MALT1	4.65521948786339
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	48/1011	248/9376	1.79496506174021	FOS/BCL2/DYNLRB1/TUBA1A/MYC/PIK3C2A/MAP2K4/KLC1/NFKBIA/DYNLT3/AKT3/MAPK8/ARPC1A/MAP2K3/RELA/CYCS/JUN/CYTH3/RIPK2/NFKB1/KPNA1/TAB2/RHOG/DYNLL2/MAP2K1/PAK1/ACTR10/BAX/TNFRSF10B/KPNA4/PLEKHM1/DCTN4/DYNC1LI2/RAC1/MYO6/PIK3CA/MAP2K7/MYL12A/RAB9A/MAPK1/ABI1/MYL9/HRAS/KPNA3/PFN1/SNX18/DCTN1/PIK3C3	4.41076896500634
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	60/1011	333/9376	1.67098849591431	ISG15/WNT6/THBS1/IRF9/HES4/JAG1/CREB5/ITGA1/CREB1/MX1/ATP6V1F/NOTCH3/PPP2R2A/IRF1/UBR4/STAT1/AKT3/CCND3/PARD6G/PARD3/RELA/PPP2CA/ATP6AP1/EIF2AK2/HDAC2/PPP2R2D/NFKB1/DLG1/PRKACB/PPP2R5E/TBPL1/RPS6KB1/JAK1/MAP2K1/PPP2R1A/BAD/BAX/RHEB/SOS2/ATP6V0A1/BCAP31/PIK3CA/LAMA3/VTN/PPP2R3C/ITGA3/HLA-E/MAML3/LAMB2/MAPK1/TRAF3/WNT4/KRAS/HRAS/NOTCH1/UBE3A/MAML1/MAML2/MTOR/DLG3	4.33420220696428
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	43/1011	216/9376	1.84621020624977	APOA1/NFATC2/MMP9/HSPA1B/FOS/ICAM1/HSPA1A/BCL2/NFATC1/IRF7/MAP2K4/ATF6/NFKBIA/CCL2/AKT3/MAPK8/CXCL2/MAP2K3/RELA/CCL3/CYCS/JUN/ERN1/NFKB1/LDLR/TAB2/POU2F1/NFE2L2/PPP3CC/BAD/BAX/MIB1/TNFRSF10B/RAC1/PIK3CA/MAP2K7/MAPK1/TRAF3/KRAS/HRAS/CAMK2D/DDIT3/RAP1A	4.37406911620756
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	40/1011	196/9376	1.89265023516825	NFATC2/ZFP36/FOS/ICAM1/IRF9/MYC/CREB1/NFATC1/IRF7/MAP2K4/ANGPT2/NFKBIA/MAPKAPK2/GNG12/MAP1LC3A/STAT1/AKT3/MAPK8/CXCL2/RELA/CYCS/EIF2AK2/JUN/NFKB1/JAK1/MAP2K1/GNG10/PPP3CC/BAX/GNB2/RAC1/PIK3CA/MAP2K7/HLA-E/MAPK1/TRAF3/KRAS/HRAS/MTOR/PIK3C3	4.39052305648818
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	31/1011	138/9376	2.08328674436273	NDUFA4L2/ATP6V1F/NDUFB4/COX8A/NDUFA7/NDUFA5/CYCS/ATP6AP1/NDUFS8/NDUFS7/UQCRH/ATP5F1B/NDUFB9/UQCRB/ATP5MC2/NDUFAB1/ATP6V0A1/COX7B/UQCR10/COX7A2/NDUFS2/NDUFC2/ATP5F1C/COX6A1/NDUFB11/COX5A/COX4I2/UQCRC1/PPA1/NDUFB8/COX5B	4.45679067247597
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	41/1011	204/9376	1.86388937375148	WNT6/MMP9/THBS1/PPP1R12B/SDC2/PLCE1/ROCK1/MYC/PLAUR/ANK3/AKT3/ESR1/IGF1R/CAV2/RRAS2/PRKACB/BRAF/RPS6KB1/MAP2K1/PAK1/CBL/ARAF/HOXD10/ARHGEF12/SOS2/RAC1/FRS2/PPP1R12C/PIK3CA/VTN/MAPK1/WNT4/KRAS/HRAS/CAV1/TGFB2/MSN/CAMK2D/PPP1R12A/GAB1/MTOR	4.33680041708287
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	38/1011	184/9376	1.91527974884961	NFATC2/EPHB6/SEMA3A/ROCK1/TRPC6/SEMA3B/UNC5C/SLIT3/EPHA3/ENAH/PARD6G/PARD3/ILK/SEMA4A/SLIT2/SRGAP1/BMPR2/PAK1/PPP3CC/PAK2/NCK2/SEMA6D/ARHGEF12/RAC1/SEMA6A/PIK3CA/MYL12A/MAPK1/SEMA3C/WNT4/KRAS/MYL9/HRAS/PLXNB2/CAMK2D/RYK/EPHA2/EFNB2	4.35899128207935
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	28/1011	122/9376	2.12845583823839	PLCE1/RCAN2/MYC/ATP1A1/NOTCH3/STAT1/AKT3/MED27/TBC1D4/ESR1/HDAC2/PRKACB/ATP1B2/MAP2K1/BAD/THRA/RHEB/NCOA1/PIK3CA/NCOA2/MAPK1/WNT4/KRAS/HRAS/NOTCH1/MTOR/SIN3A/MED17	4.36142068387444
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	31/1011	142/9376	2.02460261071871	JUND/NFATC2/FOSB/JUNB/FOS/IRF9/CREB1/NFATC1/SOCS3/NFKBIA/ACP5/STAT1/TGFBR1/AKT3/MAPK8/RELB/RELA/JUN/FHL2/NFKB1/TAB2/JAK1/MAP2K1/PPP3CC/RAC1/PIK3CA/CSF1/MAP2K7/MAPK1/TGFB2/CTSK	4.27693784194755
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	25/1011	105/9376	2.20809194102963	NFATC2/IRF9/NFATC1/PLK3/NFKBIA/MAPKAPK2/IRF1/STAT1/AKT3/EGR3/MAPK8/RELB/RELA/JUN/NFKB1/RRAS2/PAK1/PPP3CC/ARHGEF12/PIK3CA/MAPK1/KRAS/BCL3/HRAS/MALT1	4.32772433547953
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	24/1011	99/9376	2.24823906723017	MMP9/FOS/JAG1/BCL2/NOTCH3/AKT3/MAPK8/JUN/ESR1/IGF1R/PRKACB/BRAF/RPS6KB1/MAP2K1/ARAF/BAD/BAX/SOS2/PIK3CA/MAPK1/KRAS/HRAS/NOTCH1/MTOR	4.34050072700127
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	30/1011	137/9376	2.03079988737031	FOS/LMNA/BCL2/NGF/TUBA1A/CTSD/NFKBIA/AKT3/MAPK8/RELA/CYCS/JUN/ERN1/NFKB1/PMAIP1/MAP2K1/BAD/BBC3/BAX/PTPN13/TNFRSF10B/SEPTIN4/PIK3CA/MAPK1/KRAS/HRAS/DDIT3/CTSF/GADD45B/CTSK	4.22523049702321
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	35/1011	170/9376	1.90935009018444	RAPGEF2/ROCK1/ARHGAP17/TUBA1A/PPP2R2A/MPDZ/MAPK8/ARPC1A/PARD6G/PARD3/PPP2CA/JUN/RUNX1/TJP1/PPP2R2D/DLG1/PRKACB/MAP3K1/PPP2R1A/TJP2/ACTN4/RAC1/NEDD4/ACTN1/MAP2K7/PRKAA1/MYL12A/RAPGEF6/AMOTL1/MYL9/YBX3/MSN/CLDN4/RAP1A/DLG3	4.15956900076798
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	22/1011	90/9376	2.26697439279042	NFATC2/FOS/NFATC1/NFKBIA/STAT1/AKT3/MAP2K3/RELA/MAP3K3/JUN/NFKB1/BATF3/RPS6KB1/JAK1/MAP2K1/PPP3CC/EML4/PIK3CA/MAPK1/KRAS/HRAS/MTOR	4.19858544323349
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	35/1011	174/9376	1.86545698466296	HSPA1B/HSPA1A/PPP1R15A/BCL2/UBE2J1/RAD23A/ATF6/MAPK8/DNAJB1/SEC61G/RNF5/UBE2D1/ERN1/UBE2D2/TUSC3/NFE2L2/UBE2J2/RBX1/BAX/NSFL1C/ERO1B/BCAP31/GANAB/RPN1/MAP2K7/NGLY1/UBE4B/ATF6B/KRTCAP2/UFD1/DDIT3/UBXN2A/DERL1/BAG2/HYOU1	4.00596582751969
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/1011	142/9376	1.95929284908263	KLF2/MMP9/FOS/MGST3/ICAM1/SDC2/PDGFA/MEF2C/BCL2/MAP2K4/CCL2/AKT3/MAPK8/DUSP1/RELA/JUN/CAV2/NFKB1/SUMO1/NFE2L2/BMPR2/MGST2/ACVR2A/GSTM4/RAC1/PIK3CA/MAP2K7/PRKAA1/CAV1/SUMO3	4.00431918172959
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	34/1011	169/9376	1.8657723620061	BCL2/ATG13/CTSD/MTMR3/MAP1LC3A/AKT3/MAPK8/RB1CC1/IRS1/PPP2CA/IGF1R/ERN1/RRAS2/PRKACB/RPS6KB1/MAP2K1/GABARAPL2/BAD/RHEB/PLEKHM1/PIK3CA/ULK1/C9orf72/PRKAA1/MAPK1/KRAS/HRAS/ATG2B/STX17/GORASP2/NBR1/MTOR/RAB33B/PIK3C3	3.9483554389109
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	32/1011	157/9376	1.89023921576039	WNT6/ID1/CCN2/YWHAH/MYC/PPP2R2A/SMAD4/TGFBR1/CCND3/CSNK1E/PARD6G/PARD3/PPP2CA/FBXW11/YAP1/PPP2R2D/DLG1/TP53BP2/LATS2/YWHAG/TEAD2/SERPINE1/BMPR2/PPP2R1A/BBC3/SMAD7/AREG/STK3/WNT4/TGFB2/YWHAQ/DLG3	3.91059538536119
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	30/1011	144/9376	1.93208044840092	ATG13/SLC25A5/MCU/PSMC6/AKT3/MAPK8/RB1CC1/CYCS/PUM2/GTF2B/ERN1/TBPL1/PSMA2/PSMB2/PSMD11/SEM1/NOP56/PSMD7/VDAC2/SLC25A4/PSMB3/PIK3CA/ULK1/ATXN2L/ATG2B/CIC/PSMD1/ADRM1/MTOR/PIK3C3	3.91845613705558
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	40/1011	214/9376	1.73345535557466	NFATC2/FOS/BST2/B2M/BCL2/NFATC1/NFKBIA/GNG12/AKT3/MAPK8/MAP2K3/RELA/CYCS/JUN/FBXW11/WEE1/TAPBP/NFKB1/TAB2/SAMHD1/RPS6KB1/MAP2K1/GNG10/PAK1/RBX1/PPP3CC/BAD/BAX/GNB2/PAK2/CRK/RAC1/PIK3CA/MAP2K7/HLA-E/MAPK1/KRAS/HRAS/DCAF1/MTOR	3.77323340252448
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	34/1011	173/9376	1.8226331166418	ICAM1/IRF9/SLC25A5/ADAR/MX1/IRF7/SOCS3/NFKBIA/CCL2/RAB11B/STAT1/AKT3/CCND3/DNAJB1/RELA/CYCS/EIF2AK2/HNRNPUL1/NXT1/IFIH1/NFKB1/KPNA1/KPNA6/OAS2/JAK1/MAP2K1/BAX/PABPN1/TNFRSF10B/SLC25A4/PIK3CA/MAPK1/TRAF3/NUP98	3.79658189852901
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	28/1011	133/9376	1.95241813733146	KLF2/FOXO3/DEPP1/PLK3/SMAD4/TGFBR1/AKT3/MAPK8/CSNK1E/IRS1/SGK1/IGF1R/BRAF/MAP2K1/GABARAPL2/ARAF/SOS2/USP7/PIK3CA/PRKAA1/MAPK1/SETD7/KRAS/HRAS/CAT/TGFB2/GADD45B/PRMT1	3.84569860385695
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	18/1011	71/9376	2.35115141889915	PRL/FOS/FOXO3/SOCS3/IRF1/STAT1/AKT3/MAPK8/RELA/ESR1/NFKB1/MAP2K1/SOS2/PIK3CA/MAPK1/KRAS/HRAS/PRLR	3.97285990333675
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	26/1011	122/9376	1.97642327836422	JUNB/FOS/CREB5/CREB1/SOCS3/IGFBP3/MAP2K4/STAT1/AKT3/MAPK8/MAP2K3/IRS1/SSTR2/PRKACB/MAP3K1/GHR/MAP2K1/CRK/SOS2/PIK3CA/MAPK1/KRAS/HRAS/ATF6B/BCAR1/MTOR	3.77382307589653
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	16/1011	62/9376	2.39328674898695	HSPA1B/HSPA1A/FOXO3/AKT3/IRS1/IGF1R/HDAC2/PRKACB/RPS6KB1/EIF4EBP2/PIK3CA/PRKAA1/KRAS/HRAS/CAT/MTOR	3.82645383459235
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	28/1011	138/9376	1.88167834974699	NFATC2/FOS/ROCK1/NFATC1/MAP2K4/NFKBIA/CCL2/ARHGEF7/AKT3/MAPK8/ARPC1A/MAP2K3/PKN2/RELA/RPS6KA3/JUN/NFKB1/TAB2/RHOG/PIP5K1B/MAP2K1/CRK/ARHGEF12/RAC1/PIK3CA/MAP2K7/MAPK1/BCAR1	3.62734600577796
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	22/1011	99/9376	2.06088581162765	FOS/PDGFA/DGKH/AKT3/MAPK8/JUN/PIP5K1B/RPS6KB1/SLC44A2/MAP2K1/RHEB/SOS2/RAC1/PLD1/PIK3CA/LYPLA1/MAPK1/KRAS/HRAS/DGKG/MTOR/PDGFC	3.68901739860868
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	26/1011	125/9376	1.92898911968348	ROCK1/BCL2/CTSD/PPP2R2A/AKT3/MAPK8/ORMDL2/RELA/ASAH1/PPP2CA/PPP2R2D/NFKB1/PPP2R5E/SPHK1/MAP2K1/PPP2R1A/BAX/SGMS2/RAC1/PLD1/PIK3CA/PPP2R3C/MAPK1/KRAS/HRAS/SGPP1	3.63495916974189
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	42/1011	238/9376	1.63658579158666	ETS1/PDGFA/PLCE1/NGF/ANGPT2/GNG12/AKT3/MAPK8/PGF/RELA/IGF1R/NFKB1/RRAS2/PRKACB/PLA2G2A/RASGRP2/MAP2K1/GNG10/PAK1/SHOC2/BAD/GNB2/PAK2/SOS2/ETS2/RAC1/PLD1/PIK3CA/CSF1/BDNF/KITLG/MAPK1/KRAS/RALGAPB/HRAS/NTF3/ANGPT1/NF1/GAB1/RAP1A/EPHA2/PDGFC	3.45818391216166
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	28/1011	140/9376	1.85479723046489	KLF2/RYR2/JAG1/MEF2C/CCN2/HDAC5/NOTCH3/GNG12/SMAD4/MAP1LC3A/TGFBR1/AKT3/RRAS2/PRKACB/MEF2D/RPS6KB1/SPHK1/SERPINE1/MAP2K1/GNG10/GNB2/PRKAA1/MAPK1/KRAS/HRAS/MTOR/PLIN1/PIK3C3	3.54252892881502
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/1011	101/9376	2.02007619159542	ICAM1/PLCE1/BCL2/NFATC1/CCL2/PIM1/SMAD4/STAT1/TGFBR1/AKT3/MAPK8/RELA/JUN/NFKB1/SERPINE1/BAX/RAC1/PIK3CA/MAPK1/KRAS/HRAS/TGFB2	3.58314664346756
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	23/1011	109/9376	1.95689616058222	FOS/IRF9/IRF7/MAP2K4/MAP3K8/NFKBIA/STAT1/AKT3/MAPK8/MAP2K3/RELA/CCL3/JUN/NFKB1/TAB2/JAK1/MAP2K1/RAC1/PIK3CA/MAP2K7/MAPK1/TRAF3/CTSK	3.49330674833111
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/1011	59/9376	2.35779308957401	FOXO3/MYC/AKT3/ILK/BRAF/MAP2K1/ARAF/BAD/BAX/SOS2/PIK3CA/MAPK1/KRAS/HRAS/GADD45B	3.6370543876895
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	27/1011	138/9376	1.81447555154174	PTPN1/SORBS1/SOCS3/AKT3/MAPK8/IRS1/PRKAR2A/EIF4E/PRKACB/BRAF/RPS6KB1/MAP2K1/CBL/ARAF/BAD/RHEB/CRK/SOS2/PIK3CA/PRKAA1/MAPK1/KRAS/INPP5A/HRAS/MTOR/ACACB/TRIP10	3.35086445021195
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	31/1011	166/9376	1.73188898025336	NFATC2/ROCK1/TRPC6/MEF2C/PDE3A/CREB5/GUCY1A2/SLC25A5/CREB1/GUCY1B1/GUCY1A1/ATP1A1/NFATC1/AKT3/IRS1/PRKG1/ATP1B2/MEF2D/MAP2K1/PPP3CC/VDAC2/BAD/SLC25A4/ATP2B4/ATP2B1/MAPK1/MYL9/ATF6B/PDE5A/PPP1R12A/ADRA2A	3.30748345566782
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	43/1011	253/9376	1.57621108517767	PLCE1/ROCK1/FOXO3/BCL2/NFKBIA/MAP1LC3A/CAST/AKT3/MAPK8/ARPC1A/RELA/CYCS/ILK/JUN/CYTH3/RIPK2/FBXW11/UBE2N/UBE2D1/RPS6KA5/UBE2D2/NFKB1/TAB2/RPS6KB1/RBX1/BAX/CRK/ACTN4/RAC1/SEPTIN7/PIK3CA/ACTN1/GSK3A/MYL12A/MAPK1/MYL9/PFN1/MALT1/BCAR1/SEPTIN9/FNBP1/MTOR/PIK3C3	3.22999072693812
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	22/1011	106/9376	1.92478957878432	MMP9/PDGFA/CREB5/BCL2/CREB1/NFKBIA/AKT3/RELA/IGF1R/NFKB1/BRAF/MAP2K1/ARAF/BAD/SOS2/PIK3CA/MAPK1/KRAS/HRAS/AR/MTOR/PDGFC	3.32877342817801
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/1011	93/9376	1.99440562415579	ROCK1/PTPN1/SORBS1/SMURF1/SMAD4/TGFBR1/PARD3/ARHGAP29/IGF1R/TJP1/NECTIN2/ACTN4/RAC1/ACTN1/MYL12A/MAPK1/MYL9/HEG1/RAP1A/PTPRJ	3.35034178874122
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	20/1011	93/9376	1.99440562415579	NFATC2/FOS/JAG1/NFATC1/NOTCH3/NFKBIA/STAT1/MAPK8/RELA/JUN/NFKB1/JAK1/PPP3CC/MAML3/MAPK1/STAT6/NOTCH1/MAF/MAML1/MAML2	3.35034178874122
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1011	170/9376	1.69113865130622	WNT6/MGST3/MYC/SMAD4/TGFBR1/AKT3/PBRM1/IGF1R/NFE2L2/BRAF/RPS6KB1/ARID1A/MAP2K1/ARAF/BAD/BAX/MGST2/SMARCC1/GSTM4/SOS2/PIK3CA/MAPK1/WNT4/KRAS/HRAS/SMARCD1/ARID2/TGFB2/GAB1/MTOR/GADD45B	3.16142148138221
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	34/1011	193/9376	1.6337592185442	ROCK1/FOXO3/CCL8/NFKBIA/CCL2/GNG12/STAT1/AKT3/CXCL2/PARD3/RELA/CCL3/NFKB1/PRKACB/RASGRP2/BRAF/XCL2/MAP2K1/GNG10/PAK1/BAD/GNB2/CRK/SOS2/RAC1/PIK3CA/GSK3A/MAPK1/KRAS/HRAS/CCL21/CCR10/BCAR1/RAP1A	3.09270783975784
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	25/1011	130/9376	1.78345887544701	MMP9/FOS/CREB5/CREB1/MAP2K4/NFKBIA/GNG12/TGFBR1/AKT3/MAPK8/RELA/JUN/RXFP1/NFKB1/PRKACB/MAP2K1/GNG10/GNB2/SOS2/PIK3CA/MAP2K7/MAPK1/KRAS/HRAS/ATF6B	3.12708135268942
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	39/1011	232/9376	1.55898905146833	RGCC/PPP1R12B/PDGFA/ROCK1/ITGA1/ENAH/GNG12/ARHGEF7/AKT3/ARPC1A/DIAPH2/RRAS2/PIP5K1B/BRAF/MAP2K1/PAK1/ARAF/ABI2/PAK2/SPATA13/CRK/ARHGEF12/SOS2/ACTN4/RAC1/PPP1R12C/PIK3CA/ACTN1/ITGA3/MYL12A/MAPK1/KRAS/MYL9/HRAS/MSN/PFN1/PPP1R12A/BCAR1/PDGFC	2.99714275361841
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	38/1011	227/9376	1.55247345281202	NFATC2/ROCK1/B2M/CREB5/MYC/CREB1/NFATC1/NFKBIA/CCL2/GNG12/AKT3/RELA/CCL3/CYCS/IL6R/TAPBP/NFKB1/PRKACB/RPS6KB1/JAK1/MAP2K1/GNG10/PPP3CC/BAX/GNB2/RHEB/CRK/ARHGEF12/SOS2/RAC1/PIK3CA/HLA-E/MAPK1/KRAS/HRAS/ATF6B/BCAR1/MTOR	2.92931295641116
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	16/1011	73/9376	2.0326544991396	BST2/MX1/SUPT4H1/MDFIC/PSIP1/SERINC5/PIN1/SAMHD1/VPS4B/TSG101/BICD1/CPSF6/RANBP2/CDK9/FEZ1/NELFA	3.07916672188243
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1011	31/9376	2.69244759261032	SRP19/IMMP2L/SEC11C/SEC61G/SEC11A/SPCS1/OXA1L/IMMP1L/GET1	3.2812148383121
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1011	37/9376	2.50648274387147	MYC/BRAF/MAP2K1/BAX/CCDC6/MAPK1/KRAS/HRAS/GADD45B/NCOA4	3.19185444962404
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	21/1011	108/9376	1.80327508517419	RBM8A/NUP54/MAGOH/NXT1/KPNA1/KPNA6/SUMO1/UPF3B/KPNA4/RANBP2/NMD3/NUP98/NUP160/KPNA3/SAP18/THOC1/SEH1L/NUP214/PNN/SUMO3/SENP2	2.91884750157819
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	23/1011	122/9376	1.74837443855297	FOXO3/CREB5/CAB39/CREB1/PPP2R2A/RAB11B/AKT3/TBC1D1/IRS1/PPP2CA/IGF1R/PPP2R2D/PPP2R5E/RPS6KB1/PPP2R1A/ADIPOR1/RHEB/PIK3CA/ULK1/PPP2R3C/PRKAA1/MTOR/ACACB	2.89242666392966
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	28/1011	158/9376	1.64349121686762	WNT6/FNIP2/CAB39/ATP6V1F/AKT3/IRS1/RPS6KA3/SGK1/IGF1R/EIF4E/CLIP1/BRAF/RPS6KB1/MAP2K1/RHEB/SOS2/PIK3CA/ULK1/PRKAA1/MAPK1/SLC7A5/WNT4/KRAS/HRAS/SESN2/SEH1L/MTOR/RICTOR	2.83583565397341
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1011	44/9376	2.31849653808111	VAMP2/CREB5/CREB1/RAB11B/ARHGDIA/PRKACB/DYNLL2/DCTN4/DYNC1LI2/ARHGDIB/DCTN1	3.04751751522897
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1011	76/9376	1.95241813733146	PDGFA/CAMK1D/AKT3/IGF1R/BRAF/MAP2K1/ARAF/BAX/SOS2/PIK3CA/MAPK1/KRAS/HRAS/CAMK2D/MTOR/GADD45B	2.89815242188238
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	20/1011	103/9376	1.80077401016008	PELO/RBM8A/PPP2R2A/MAGOH/PPP2CA/NXT1/PPP2R2D/PPP2R5E/UPF3B/PPP2R1A/PCF11/SMG7/RNMT/PABPN1/SMG1/CPSF6/PPP2R3C/SAP18/RNGTT/PNN	2.84083948152582
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	17/1011	83/9376	1.89949113963271	SCMH1/UBE2D1/HDAC2/UBE2D2/AEBP2/YAF2/RBBP7/USP7/LCOR/PHC2/YY1/MAX/L3MBTL4/PHF1/SUZ12/RYBP/HCFC1	2.86145032337958
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	35/1011	212/9376	1.53108261948752	THBS1/ID1/RAPGEF2/PDGFA/PLCE1/NGF/ANGPT2/ENAH/AKT3/PGF/MAP2K3/PARD6G/PARD3/IGF1R/RASGRP2/BRAF/PRKD3/MAP2K1/SIPA1L1/CRK/RAC1/PIK3CA/CSF1/KITLG/MAPK1/RAPGEF6/KRAS/PRKD1/HRAS/PFN1/ANGPT1/BCAR1/RAP1A/EPHA2/PDGFC	2.71904078674661
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	25/1011	139/9376	1.66798312092166	MMP9/HSPA1B/FOS/HSPA1A/CREB5/BCL2/KRT23/CREB1/CTSD/AKT3/FKBP5/JUN/KRT18/ESR1/KRT10/PRKACB/MAP2K1/SOS2/NCOA1/PIK3CA/NCOA2/MAPK1/KRAS/HRAS/ATF6B	2.75826291411194
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	18/1011	91/9376	1.83441484331692	NFATC2/FOS/NFATC1/NFKBIA/AKT3/RELA/JUN/NFKB1/IFITM1/MAP2K1/PPP3CC/SOS2/RAC1/PIK3CA/MAPK1/KRAS/HRAS/MALT1	2.78060952798444
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	20/1011	105/9376	1.7664735528237	FOXO3/PHB2/SMURF1/MAP1LC3A/MAPK8/RELA/JUN/RRAS2/SIAH1/GABARAPL2/CITED2/CCZ1B/ULK1/FIS1/TFE3/KRAS/HRAS/MON1B/CCZ1/NBR1	2.74572334637835
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	16/1011	78/9376	1.90235613381014	BTG2/TENT4B/BTG3/LSM5/LSM8/LSM6/LSM2/DCP1A/PATL1/PAN3/DHX36/NUDT16/XRN2/CNOT4/CNOT6/TOB2	2.7820103961719
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	35/1011	217/9376	1.49580421811684	FOS/MGST3/JAG1/CREB5/BCL2/MYC/CREB1/AKT3/CCND3/RELA/RPS6KA3/JUN/ESR1/KLF4/NFKB1/KPNA1/KPNA6/PRKACB/RPS6KB1/EPHX1/MAP2K1/BAD/MGST2/KPNA4/AIP/GSTM4/SOS2/PIK3CA/MAPK1/KRAS/HRAS/ATF6B/AR/KPNA3/MTOR	2.56888284199095
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	30/1011	180/9376	1.54566435872074	IRF9/BST2/B2M/BCL2/IRF7/SOCS3/NFKBIA/CCL2/STAT1/AKT3/RELA/CYCS/EIF2AK2/IFIH1/TAPBP/NFKB1/TAB2/OAS2/POU2F1/JAK1/BAD/BAX/RHEB/NECTIN2/PIK3CA/HLA-E/TRAF3/SP100/MTOR/HCFC1	2.56974838859852
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/1011	73/9376	1.90561359294338	FOXO3/AKT3/RARB/BRAF/MAP2K1/ARAF/BAD/BAX/SOS2/EML4/PIK3CA/MAPK1/KRAS/HRAS/GADD45B	2.70035645087395
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1011	41/9376	2.26194784203035	MMP9/THBS1/MYC/RPS6KA5/BRAF/MAP2K1/ARAF/MAPK1/KRAS/HRAS	2.81516863944226
Organismal Systems	Nervous system	hsa04730	Long-term depression	13/1011	60/9376	2.00936366633696	GUCY1A2/GUCY1B1/GUCY1A1/PPP2CA/IGF1R/PRKG1/BRAF/MAP2K1/PPP2R1A/ARAF/MAPK1/KRAS/HRAS	2.72669647161524
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	36/1011	226/9376	1.47727213045876	FOS/RYR2/PLCE1/FXYD1/ROCK1/PDE3A/CREB5/CREB1/ATP1A1/NFATC1/NFKBIA/AKT3/MAPK8/RELA/JUN/SSTR2/NFKB1/RRAS2/PRKACB/ATP1B2/BRAF/MAP2K1/PAK1/BAD/GLI3/ATP2B4/RAC1/PLD1/ATP2B1/PIK3CA/BDNF/MAPK1/MYL9/CAMK2D/PPP1R12A/RAP1A	2.524864005471
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	39/1011	250/9376	1.44674183976261	IDS/AP3S1/ATP6V1F/CTSD/BORCS7/ACP5/ASAH1/CLTB/ATP6AP1/NEU1/WDR7/TPP1/VPS26A/OSBP/SLC17A5/BLOC1S1/GLA/GNS/PLEKHM1/GNPTG/SORT1/ATP6V0A1/AP3M1/VPS13A/CD68/LITAF/VPS29/TFE3/CTSA/GPR155/AGA/STX17/AP2B1/DTNBP1/GALNS/CTSF/SNAPIN/MTOR/CTSK	2.48894124070831
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1011	75/9376	1.85479723046489	THBS1/BCL2/EI24/IGFBP3/CCND3/CYCS/SIAH1/SERPINE1/PMAIP1/BBC3/BAX/TNFRSF10B/SESN2/GADD45B/RCHY1	2.58378967980484
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/1011	103/9376	1.71073530965208	FOS/MAP2K4/PPP2R2A/NFKBIA/CCL2/TGFBR1/AKT3/MAPK8/RELA/CCL3/PPP2CA/JUN/PPP2R2D/NFKB1/SERPINE1/PPP2R1A/PIK3CA/MAPK1/TGFB2	2.52141665807869
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	13/1011	62/9376	1.9445454835519	JAG1/NRARP/NOTCH3/SPEN/HDAC2/DTX3/ITCH/MAML3/NOTCH1/PSENEN/MAML1/APH1A/MAML2	2.59405301178091
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1011	71/9376	1.82867332581045	ATP6V1F/MAP2K4/NFKBIA/MAPK8/CXCL2/RELA/ADAM10/ATP6AP1/JUN/TJP1/NFKB1/PAK1/ATP6V0A1/RAC1	2.43659073515193
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	10/1011	46/9376	2.01608394615748	PSMF1/PSMC6/PSMA2/PSMB2/PSMD11/SEM1/PSMD7/PSMB3/PSMD1/ADRM1	2.40157374479496
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/1011	73/9376	1.77857268674715	PDGFA/AKT3/IGF1R/BRAF/MAP2K1/ARAF/BAD/BAX/PIK3CA/MAPK1/KRAS/HRAS/GADD45B/PDGFC	2.32154617986546
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	19/1011	109/9376	1.61656639352444	NFATC2/FOS/NFATC1/NFKBIA/SMAD4/STAT1/TGFBR1/MAPK8/RELA/IL6R/JUN/RUNX1/NFKB1/JAK1/PPP3CC/IL1RAP/MAPK1/STAT6/MTOR	2.25087698333182
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/1011	109/9376	1.61656639352444	PTPN1/CREB5/CREB1/SOCS3/NFKBIA/AKT3/MAPK8/IRS1/RELA/RPS6KA3/TBC1D4/NFKB1/RPS6KB1/PTPA/PIK3CA/PRKAA1/OGA/MTOR/ACACB	2.25087698333182
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1011	60/9376	1.85479723046489	NFATC2/MAPKAPK2/AKT3/SPHK1/MAP2K1/PPP3CC/BAD/RAC1/PIK3CA/MAPK1/KRAS/HRAS	2.30915047766044
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1011	34/9376	2.18211438878222	POLR2J/POLR2I/POLR3GL/POLR2K/POLR2F/POLR2J3/POLR2G/POLR2H	2.40053075283013
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/1011	110/9376	1.60187033540149	EPAS1/BCL2/ANGPT2/AKT3/RELA/IL6R/IGF1R/EIF4E/NFKB1/RPS6KB1/SERPINE1/MAP2K1/RBX1/PIK3CA/MAPK1/LTBR/CAMK2D/ANGPT1/MTOR	2.20740172000414
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	24/1011	148/9376	1.50388964632288	WNT6/FOS/JAG1/MYC/NOTCH3/AKT3/JUN/ESR1/IGF1R/BRAF/RPS6KB1/MAP2K1/ARAF/BAX/SOS2/NCOA1/PIK3CA/MAPK1/WNT4/KRAS/HRAS/NOTCH1/MTOR/GADD45B	2.14803198012186
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	17/1011	97/9376	1.62533777927335	FOS/RYR2/PER2/GUCY1A2/CREB1/GUCY1B1/GUCY1A1/GNG12/PER1/RPS6KA5/PRKG1/PRKACB/GNG10/GNB2/PER3/MAPK1/CAMK2D	2.15217801240392
NA	NA	hsa04517	IgSF CAM signaling	43/1011	299/9376	1.33371707207341	ICAM1/RAPGEF2/TRPC6/UNC5C/TUBA1A/SORBS1/SLIT3/KIRREL1/MPDZ/NTRK3/ANK3/AKT3/MAPK8/ARPC1A/PARD6G/PARD3/PPFIA1/ESAM/NFASC/PMP22/SLIT2/SRGAP1/TJP1/DYNLL2/MAP2K1/PAK1/IL1RAP/TJP2/PAK2/NCK2/NECTIN2/ACTN4/RAC1/PIK3CA/ACTN1/MYL12A/CASK/MAPK1/RAPGEF6/MYL9/MSN/BCAR1/RAP1A	2.03878342580226
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	25/1011	157/9376	1.47674938731281	NFATC2/THBS1/ANO6/CREB1/DUSP8/NFATC1/GULP1/MAPKAPK2/GAS6/ADAM10/SGK1/ODC1/SPHK1/MAP2K1/XKR6/CRK/RAC1/ADAM9/PPARD/MAPK1/DUSP5/CAMK2D/BCAR1/PROS1/MFGE8	2.09423930219339
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/1011	112/9376	1.57326550798361	HSPA1B/HSPA1A/BCL2/NFKBIA/STAT1/AKT3/MAPK8/MAP2K3/RELA/CYCS/NFKB1/LDLR/TAB2/JAK1/BAD/LAMA3/LAMB2/MAPK1/TGFB2	2.12174796147291
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	11/1011	55/9376	1.85479723046489	UGCG/ASAH1/NEU1/B4GALT5/SPHK1/GLA/ACER3/SGMS2/SAMD8/SGPP1/CERK	2.21025020992584
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	10/1011	49/9376	1.89265023516825	FOSB/CREB5/CREB1/RELA/JUN/NFKB1/PRKACB/MAOA/BDNF/ATF6B	2.17789339958545
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1011	78/9376	1.66456161708387	ARPC1A/CLTB/ARHGAP10/ILK/CAV2/RHOG/CBL/CRK/RAC1/PIK3CA/CAV1/BCAR1/GAB1/SEPTIN9	2.04887766409658
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/1011	93/9376	1.59552449932463	BCL2/MYC/NFKBIA/AKT3/RELA/CYCS/NFKB1/RARB/BAX/PIK3CA/LAMA3/ITGA3/LAMB2/TRAF3/MAX/GADD45B	2.00643536987269
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/1011	94/9376	1.5785508344382	JUND/FOSB/MMP9/FOS/NFKBIA/CCL2/MAPK8/CXCL2/RELA/USP25/JUN/NFKB1/TAB2/TNFAIP3/MAPK1/TRAF3	1.95980523044938
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	28/1011	187/9376	1.38861824740687	IRF9/BCL2/MCU/IRF7/NEK7/NFKBIA/CCL2/MAP1LC3A/STAT1/DNM1L/MAPK8/CXCL2/PKN2/RELA/JUN/RIPK2/NFKB1/TAB2/TNFAIP3/OAS2/JAK1/GABARAPL2/VDAC2/NAMPT/GBP1/MAPK1/TRAF3/ANTXR2	1.86611373638086
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	21/1011	133/9376	1.46431360299859	FOS/CREB5/CREB1/PPP2R2A/GNG12/AKT3/MAPK8/PPP2CA/PPP2R2D/PRKACB/PPP2R5E/GNG10/PPP3CC/MAOA/PPP2R1A/GNB2/CLOCK/GSK3A/PPP2R3C/ATF6B/CAMK2D	1.87481748279858
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1011	32/9376	2.02868447082097	BCL2/MAPK8/CYCS/PMAIP1/BBC3/BAX/SEPTIN4	2.02637118579903
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	22/1011	144/9376	1.41685899549401	WNT6/ID1/ID3/MYC/KAT6A/SMAD4/AKT3/SKIL/IGF1R/RIF1/KLF4/ZFHX3/BMPR2/JAK1/MAP2K1/ACVR2A/PIK3CA/MAPK1/WNT4/KRAS/HRAS/INHBA	1.75247071428509
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	16/1011	98/9376	1.5141201881346	AKT3/ARPC1A/ASAP1/PIP5K1B/RPS6KB1/ASAP2/SPHK1/MAP2K1/PAK1/CRK/RAC1/PLD1/PIK3CA/MAPK1/AMPH/MARCKSL1	1.77860191219174
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	16/1011	98/9376	1.5141201881346	NR4A1/CREB5/CREB1/ATP1A1/CAMK1D/NR4A2/LDLR/PRKACB/ATP1B2/PRKD3/ATP2B4/ATP2B1/PRKD1/ATF6B/CAMK2D/ATF1	1.77860191219174
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	25/1011	168/9376	1.38005746314352	PRL/IRF9/PDGFA/BCL2/MYC/SOCS3/PIM1/STAT1/AKT3/CCND3/IL6R/PTPN2/GHR/JAK1/CLCF1/SOS2/PIK3CA/PIAS1/HRAS/STAT6/PIAS2/FHL1/MTOR/OSMR/PRLR	1.72802290210057
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	33/1011	233/9376	1.313483017282	THBS1/SDC2/LMNA/CSRP2/ITGA1/ATP1A1/SGCE/DMD/PDLIM5/LBR/BGN/ANK3/FBN2/SYNE2/DIAPH2/CAPZB/FHL2/PDLIM3/ATP1B2/SYNE1/SYNPO2/TMOD1/NID2/DAG1/ITGA3/DAAM2/SNTB1/LMOD1/MYL9/PDLIM7/INF2/FHL1/SNTA1	1.68451879967992
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/1011	69/9376	1.61286715692599	MAP2K4/AKT3/MAPK8/MAP2K3/MAP2K1/SOS2/RAC1/PIK3CA/MAP2K7/MAPK1/KRAS/HRAS	1.77629167436773
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	23/1011	154/9376	1.38507585391858	NFATC2/FOS/PPP1R12B/RYR2/ROCK1/MEF2C/GUCY1A2/GUCY1B1/GUCY1A1/NFATC1/CAMK1D/JUN/PRKACB/MAP2K1/PPP3CC/PPP1R12C/PRKAA1/MAPK1/KRAS/MYL9/HRAS/CAMK2D/PPP1R12A	1.6750290059411
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1011	21/9376	2.20809194102963	DSE/CHST11/CHPF/CHST12/CSGALNACT2	1.92670836105297
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/1011	93/9376	1.49580421811684	MAP2K4/MAPK8/MAP2K3/MAP3K3/JUN/PRKACB/MAP3K1/MAP2K1/SOS2/PLD1/MAP2K7/MAPK1/KRAS/HRAS/CAMK2D	1.67045876515556
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	26/1011	181/9376	1.33217480641124	BCL2/CREB1/PLK3/CTSD/MRC2/STAT1/AKT3/MAPK8/RELA/CYCS/ATP6AP1/RIPK2/NFYB/NFKB1/SPHK1/JAK1/PPP3CC/BAD/BAX/ARHGEF12/ATP6V0A1/MAPK1/TGFB2/CAMK2D/MALT1/PIK3C3	1.56876667298075
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	14/1011	87/9376	1.49236558773037	RYR2/ATP1A1/COX8A/ATP1B2/UQCRH/UQCRB/COX7B/UQCR10/COX7A2/COX6A1/COX5A/COX4I2/UQCRC1/COX5B	1.60395093836079
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	12/1011	72/9376	1.54566435872074	ISG15/ADAR/IRF7/NFKBIA/MAPK8/RELA/IFIH1/NFKB1/PIN1/MAP3K1/ZNFX1/TRAF3	1.61579116270817
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	22/1011	150/9376	1.36018463567425	WNT6/BCL2/MYC/SMAD4/TGFBR1/AKT3/RARB/BRAF/RPS6KB1/MAP2K1/ARAF/BAX/SOS2/PIK3CA/MAPK1/WNT4/KRAS/HRAS/TGFB2/GAB1/MTOR/GADD45B	1.54593892014982
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1011	29/9376	1.91875575565333	CSNK1E/YAP1/LATS2/TEAD2/PAK1/STK3	1.72262677704334
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	28/1011	201/9376	1.29189856848301	MMP9/PDGFA/MEF2C/PER2/ETV6/MYC/MLF1/IGFBP3/NR4A3/RELA/RUNX1/RUNX1T1/IGF1R/HDAC2/NFKB1/CDK14/BAX/HOXA9/KLF3/CDK9/EWSR1/MAX/TFE3/DDIT3/ATF1/MAF/GADD45B/SIN3A	1.45430400706253
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/1011	89/9376	1.45882928238811	PDGFA/GUCY1A2/TUBA1A/GUCY1B1/GUCY1A1/TJP1/PRKG1/PRKACB/MAP2K1/SOS2/MAPK1/KRAS/HRAS/PDGFC	1.51194728887737
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1011	30/9376	1.85479723046489	MDH1/MDH2/CS/IDH3G/OGDH/ACO1	1.6301932431922
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	25/1011	178/9376	1.30252614498939	NFATC2/WNT6/LGR4/MYC/NFATC1/SMAD4/MAPK8/CCND3/CSNK1E/TBL1XR1/JUN/FBXW11/PRKACB/SIAH1/RBX1/PPP3CC/FRZB/RAC1/PPARD/DAAM2/WNT4/CAMK2D/RYK/BAMBI/SENP2	1.41662354330668
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/1011	67/9376	1.5225947414264	RPS6KA3/PRKACB/BRAF/MAP2K1/PPP3CC/ARAF/MAPK1/KRAS/HRAS/CAMK2D/RAP1A	1.49237912253756
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/1011	75/9376	1.48383778437191	MGST3/BCL2/AKT3/CYCS/PMAIP1/BAD/BBC3/BAX/MGST2/GSTM4/PIK3CA/MAPK1	1.46249312632878
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1011	38/9376	1.70836587016503	ATP1A1/IRS1/SGK1/ATP1B2/PIK3CA/MAPK1/KRAS	1.52107537356787
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1011	69/9376	1.47846156051549	FOSB/FOS/CREB5/CREB1/JUN/HDAC2/PRKACB/PPP3CC/MAOA/ATF6B/CAMK2D	1.38673981277037
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/1011	149/9376	1.30707187381754	PDGFA/DGKH/AKT3/CYTH3/AVPR1A/RRAS2/PIP5K1B/SPHK1/MAP2K1/RHEB/SOS2/PLD1/PIK3CA/KITLG/MAPK1/KRAS/HRAS/GAB1/DGKG/MTOR/PDGFC	1.31350326422573
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1011	32/9376	1.73887240356083	ATG13/PPP2CA/GABARAPL2/ATG2B/MTOR/PIK3C3	1.45548007287681
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	17/1011	117/9376	1.34750226144885	EPC2/CDK2AP2/PBRM1/HDAC2/BCL7B/BAZ2A/ARID1A/ING3/BAZ2B/SMARCC1/RBBP7/VPS72/YY1/EPC1/SMARCD1/BAZ1B/ARID2	1.31491223789858
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	22/1011	158/9376	1.29131452753884	CDKN1C/YWHAH/MYC/CCNH/SMAD4/CCND3/PPP2CA/WEE1/HDAC2/PPP2R5E/YWHAG/ANAPC10/RBX1/PPP2R1A/NIPBL/TGFB2/CDC14B/MCM3/YWHAQ/GADD45B/ATRX/STAG1	1.28380947876251
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1011	70/9376	1.45734068107955	SOCS3/NFKBIA/AKT3/MAPK8/IRS1/RELA/NFKB1/ADIPOR1/PRKAA1/MTOR/ACACB	1.33516694978016
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	19/1011	134/9376	1.31496818577734	PPP1R12B/CALD1/ROCK1/GUCY1A2/GUCY1B1/GUCY1A1/AVPR1A/PRKG1/PRKACB/PLA2G2A/BRAF/MAP2K1/ARAF/PPP1R14A/ARHGEF12/PPP1R12C/MAPK1/MYL9/PPP1R12A	1.27662795254848
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/1011	78/9376	1.42676710035761	PLCE1/PIK3C2A/MTMR3/IP6K2/ISYNA1/IMPA2/PIP5K1B/PI4KB/PIK3CA/INPP5A/MTMR2/PIK3C3	1.31574493202126
Genetic Information Processing	Transcription	hsa03040	Spliceosome	32/1011	243/9376	1.22126566614972	HSPA1B/HSPA1A/RBM8A/PCBP1/BCAS2/MAGOH/LSM5/LSM8/DHX15/CWC25/WBP11/PRPF38B/SF3B4/SNRNP70/SF3B6/LSM6/LSM2/SRSF10/SF3B2/CTNNBL1/CDC40/SNRPA/PQBP1/TRA2B/U2AF2/SF3A3/PRPF31/THOC1/AQR/PPIL1/RP9/YJU2	1.21489482152467
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/1011	63/9376	1.47206129401975	POLR2J/POLR2I/POLR2K/RAD23A/CCNH/POLR2F/RBX1/POLR2J3/POLR2G/POLR2H	1.30692934404641
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/1011	95/9376	1.36669269613202	FOS/ICAM1/ATP6V1F/CCL2/ACP5/CXCL2/CCL3/ATP6AP1/JUN/ATP6V0A1/CSF1/TGFB2/ANGPT1/CTSK	1.2488058351192
NA	NA	hsa04518	Integrin signaling	21/1011	154/9376	1.26463447531697	THBS1/ICAM1/PDGFA/ITGA1/AKT3/PGF/CCND3/PARVA/ILK/IGF1R/NCK2/ACTN4/RAC1/PIK3CA/ACTN1/LAMA3/VTN/ITGA3/LAMB2/MTOR/PDGFC	1.15112494750617
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	19/1011	138/9376	1.27685316589974	YWHAH/CPEB4/RPS6KA3/PPP2CA/FBXW11/IGF1R/SPDYE2/PRKACB/PPP2R5E/YWHAG/ANAPC10/MAP2K1/RBX1/PPP3CC/PPP2R1A/MAPK1/AR/CAMK2D/YWHAQ	1.13901200568392
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1011	42/9376	1.54566435872074	MAP1LC3A/PCBP1/SLC40A1/PCBP2/VDAC2/GPX4/NCOA4	1.23209608633911
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	14/1011	98/9376	1.32485516461778	PLCE1/DGKH/PIK3C2A/MTMR3/IP6K2/IMPA2/PIP5K1B/PI4KB/PIK3CA/CDS2/INPP5A/MTMR2/DGKG/PIK3C3	1.12383841426447
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	16/1011	115/9376	1.29029372554079	FOS/CREB5/BCL2/CREB1/GNG12/AKT3/PRKACB/MAP2K1/GNG10/GNB2/PIK3CA/MAPK1/KRAS/HRAS/ACHE/CAMK2D	1.08889466609448
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/1011	115/9376	1.29029372554079	JUND/FOS/MEF2C/CREB5/BCL2/CREB1/NR4A2/SGK1/PRKACB/MEF2D/BRAF/MAP2K1/ARAF/PLD1/MAPK1/ATF6B	1.08889466609448
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/1011	200/9376	1.20561819980218	FOS/ROCK1/TUBA1A/NFKBIA/MAPK8/ARPC1A/RELA/CYCS/JUN/CYTH3/MYO1C/TJP1/NFKB1/TAB2/PAK1/BAX/PAK2/TNFRSF10B/NCK2/ARHGEF12/RAC1/MYO6/MAPK1/ABI1/MYO1D/CLDN4	1.02182868773781
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1011	44/9376	1.4754068878698	CCNH/TAF3/GTF2B/TAF9B/TBPL1/GTF2A2/TAF2	1.09883551135617
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/1011	110/9376	1.26463447531697	AKT3/MAPK8/CPEB4/RPS6KA3/IGF1R/SPDYE2/PRKACB/BRAF/ANAPC10/MAP2K1/ARAF/KIF22/PIK3CA/MAPK1/KRAS	0.970565521554395
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1011	53/9376	1.39984696638859	ATP1A1/CLTB/ESR1/PRKACB/ATP1B2/ATP2B4/ATP2B1/AP2B1	1.01480393235477
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/1011	78/9376	1.30786984199447	FOS/NFKBIA/STAT1/RELA/JUN/NFKB1/TAB2/JAK1/MAPK1/TGFB2/MARCKSL1	0.949178565983604
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/1011	70/9376	1.32485516461778	ICAM1/SGCE/DMD/CYCS/RAC1/DAG1/HLA-E/SNTB1/CAV1/SNTA1	0.948386831101955
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	20/1011	154/9376	1.20441378601616	RYR2/CREB5/BCL2/CREB1/ATP1A1/PPP2R2A/AKT3/PPP2CA/RPS6KA5/PPP2R2D/PRKACB/PPP2R5E/ATP1B2/PPP2R1A/ATP2B4/ATP2B1/PPP2R3C/MAPK1/ATF6B/CAMK2D	0.889172918288712
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	14/1011	104/9376	1.2484212128129	DGKH/LCLAT1/ETNK1/PLA2G2A/SGMS2/PLD1/CDS2/LYPLA1/PLPP5/SAMD8/ACHE/PTDSS1/DGKG/MBOAT1	0.885618906075803
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1011	23/9376	1.61286715692599	RCE1/HMGCS1/ZMPSTE24/ICMT	1.02301745224292
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1011	23/9376	1.61286715692599	ATP1A1/MDH1/ATP1B2/GLUD1	1.02301745224292
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1011	71/9376	1.30619523272175	MYC/NTRK3/AKT3/MAP2K1/PIK3CA/MAPK1/SLC7A5/KRAS/HRAS/MTOR	0.900321566967104
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1011	31/9376	1.49580421811684	MDH1/MDH2/CS/CAT/ACO1	0.961235174717338
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/1011	105/9376	1.23653148697659	ICAM1/BCL2/NFKBIA/RELB/CXCL2/RELA/NFKB1/TAB2/TNFAIP3/TRAF3/LTBR/CCL21/MALT1/GADD45B	0.847322159456942
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/1011	56/9376	1.32485516461778	MGAT5/TUSC3/ALG5/GANAB/RPN1/ALG9/KRTCAP2/ALG2	0.847625622506508
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1011	56/9376	1.32485516461778	BCL2/SMURF1/CSNK1E/FBXW11/MOSMO/PRKACB/GLI3/SPOPL	0.847625622506508
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/1011	56/9376	1.32485516461778	HSPA1B/HSPA1A/NFKBIA/CXCL2/RELA/CYCS/NFKB1/RAB1B	0.847625622506508
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	17/1011	133/9376	1.18539672623696	NFATC2/ICAM1/NFATC1/KLRC3/BRAF/MAP2K1/PAK1/PPP3CC/ARAF/TNFRSF10B/SOS2/RAC1/PIK3CA/HLA-E/MAPK1/KRAS/HRAS	0.748599699336663
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/1011	116/9376	1.19922234728333	MMP9/ICAM1/ROCK1/ESAM/ACTN4/RAC1/PIK3CA/ACTN1/THY1/MYL12A/MYL9/MSN/CLDN4/BCAR1/RAP1A	0.750567572728886
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1011	83/9376	1.22908250211529	POLR3GL/ADAR/POLR2K/IRF7/NFKBIA/PCBP1/RELA/POLR2F/NFKB1/SAMHD1/POLR2H	0.728754482257656
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1011	33/9376	1.40514941701885	CS/IDH3G/OGDH/ACO1/ACY1	0.81050790918866
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1011	10/9376	1.85479723046489	SELENBP1/ETHE1	0.940187067368886
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1011	18/9376	1.54566435872074	MMADHC/LMBRD1/HCFC1	0.80556124283515
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/1011	51/9376	1.27290006012296	ATP6V1F/SEC61G/ATP6AP1/TJP1/PRKACB/TJP2/ATP6V0A1	0.679348377497083
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/1011	69/9376	1.20965036769449	PDE1A/PDE3A/GUCY1A2/CREB1/GUCY1B1/GUCY1A1/PRKACB/PPP3CC/REN	0.607636089575657
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1011	52/9376	1.2484212128129	APOA1/VAPA/STARD3NL/LDLR/APOC1/VDAC2/SORT1	0.624478456418691
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1011	27/9376	1.37392387441843	ELOVL1/HACD2/FADS2/TECR	0.676411122956448
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1011	61/9376	1.21626047899337	ATP1A1/SLC40A1/ATP1B2/MT1E/ATP2B4/ATP2B1/MT2A/SLC39A4	0.589086258030767
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1011	19/9376	1.46431360299859	IDS/GNS/GALNS	0.704284509707696
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	18/1011	149/9376	1.12034732041503	NDUFA4L2/NDUFB4/GNG12/NDUFA7/MAPK8/NDUFA5/NDUFS8/NDUFS7/PRKACB/NDUFB9/GNG10/GNB2/NDUFAB1/NDUFS2/MAPK1/NDUFC2/NDUFB11/NDUFB8	0.514786965802977
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	20/1011	168/9376	1.10404597051481	IRF9/BCL2/SLC25A5/STAT1/DNM1L/MAPK8/CHMP5/EIF2AK2/CHMP1B/TNFAIP3/VPS4B/JAK1/VDAC2/BAX/TNFRSF10B/SLC25A4/GLUD1/STAT6/SPATA2L/CAMK2D	0.473070094279362
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1011	54/9376	1.20218339011613	CISD1/MDH1/MDH2/ADI1/KYAT3/MAT2B/APIP	0.517983646051377
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1011	20/9376	1.39109792284866	CYB5R3/NANS/CYB5R4	0.608672448635127
NA	NA	hsa04519	Cadherin signaling	46/1011	404/9376	1.05594891833397	WNT6/ROCK1/YWHAH/KRT23/LHFPL6/CDH6/NFKBIA/MPDZ/ENAH/MAPK8/ARPC1A/MAP2K3/RELA/ADAM10/KRT18/IGF1R/KRT10/YAP1/MYO1C/TJP1/NFKB1/RRAS2/LATS2/YWHAG/FAT1/TEAD2/MAP2K1/SHOC2/ABI2/ACTN4/RAC1/ACTN1/STK3/DAAM2/MAPK1/AMOTL1/WNT4/KRAS/HRAS/MYO1D/RERE/PCDH20/YWHAQ/RYK/PSENEN/APH1A	0.399637274208588
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1011	38/9376	1.22026133583216	PNP/NMRK1/NAMPT/SIRT7/SIRT2	0.47296758327079
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/1011	100/9376	1.11287833827893	ACKR3/CCL8/CCL2/CXCL2/CCL3/IL6R/XCL2/TNFRSF10B/CSF1/LTBR/CCL21/CCR10	0.394510422056989
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1011	47/9376	1.18391312582865	SOCS3/MAPK8/IRS1/PIK3CA/MAPK1/MTOR	0.439412443774285
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1011	48/9376	1.15924826904055	CD9/LDLR/CHMP1B/VPS4B/TSG101/CLDN4	0.384529190570956
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1011	66/9376	1.12411953361508	NFATC1/STAT1/RELA/JUN/NFKB1/STAT6/TGFB2/MAF	0.351775432494672
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/1011	50/9376	1.11287833827893	THBS1/ICAM1/SDC2/CCL2/KLRB1/TGFB2	0.278212185167187
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1011	23/9376	1.20965036769449	ASL/GLUD1/ACY1	0.349955096462299
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1011	23/9376	1.20965036769449	LNPEP/CTSA/REN	0.349955096462299
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1011	115/9376	1.04836365200189	KCND2/GNG12/DUSP1/PRKACB/BRAF/MAP2K1/GNG10/MAOA/ARAF/GNB2/MAPK1/KRAS/HRAS	0.181412542071324
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/1011	33/9376	1.12411953361508	VAMP2/STX3/USE1/STX17	0.24830311843976
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1011	79/9376	1.05653006798633	VAMP2/ATP6V1F/CLTB/STX3/NAPA/SLC6A1/UNC13B/ATP6V0A1/AP2B1	0.175408195691976
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1011	24/9376	1.15924826904055	EXT1/HS6ST3/EXT2	0.27155408204696
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1011	144/9376	1.03044290581383	FOXO3/MAP2K4/NFKBIA/AKT3/MAPK8/CXCL2/MAP2K3/RELA/NFKB1/TAB2/TRA2B/ADIPOR1/MAP2K7/PRKAA1/TRAF3/ACACB	0.127981647207216
Organismal Systems	Immune system	hsa04611	Platelet activation	14/1011	126/9376	1.03044290581383	ROCK1/GUCY1A2/GUCY1B1/GUCY1A1/AKT3/PRKG1/PRKACB/RASGRP2/ARHGEF12/PIK3CA/MYL12A/MAPK1/PPP1R12A/RAP1A	0.119599331884911
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/1011	99/9376	1.03044290581383	RYR2/LMNA/ITGA1/SGCE/DMD/DAG1/ITGA3/PRKAA1/SNTB1/TGFB2/SNTA1	0.105859092449456
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	14/1011	128/9376	1.01434223541048	PDE1A/PDE3A/GUCY1A2/GUCY1B1/GUCY1A1/HPRT1/PNP/NME3/PGM2/AK1/ENTPD2/NUDT16/NME7/PDE5A	0.0567971003422221
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1011	44/9376	1.05386206276414	TUSC3/RPN1/ALG9/KRTCAP2/ALG2	0.124494509419775
Cellular Processes	Cell motility	hsa04814	Motor proteins	21/1011	194/9376	1.00388509896295	DYNLRB1/TUBA1A/KLC1/DYNLT3/KIF1B/CAPZB/MYO1C/DYNLL2/KIF4A/MYO9B/ACTR10/DCTN4/DYNC1LI2/MYO6/KIF22/MYL12A/MYL9/MYO1D/MYO9A/KIF21A/DCTN1	0.0190091435319334
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	32/1011	298/9376	0.995864284813362	PRL/IL1RL1/NGF/ACKR3/TNFRSF12A/CCL8/CCL2/TGFBR1/CXCL2/CCL3/IL6R/TNFSF12/TNFRSF21/RELL1/TNFSF9/XCL2/GHR/BMPR2/GDF11/IL1RAP/TNFRSF10B/ACVR2A/CLCF1/CSF1/INHBA/TGFB2/LTBR/CCL21/CCR10/TNFRSF18/OSMR/PRLR	-0.0252227194232573
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1011	26/9376	1.0700753252682	APOA1/BTD/LMBRD1	0.124386782522855
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1011	93/9376	0.997202812077896	VAMP2/GUCY1A2/GUCY1B1/GUCY1A1/ATP1A1/PRKG1/PRKACB/ATP1B2/ATP2B4/ATP2B1	-0.00942425843009889
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/1011	65/9376	0.998736970250323	DGKH/LCLAT1/DGAT1/GLA/PLPP5/DGKG/MBOAT1	-0.00355222395339722
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1011	17/9376	1.09105719439111	DAG1/PCDH20	0.130632802899169
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/1011	85/9376	0.981951474951999	HPRT1/PNP/NME3/UPP1/AK1/ENTPD2/NUDT16/NME7/CDA	-0.0581096410384647
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/1011	76/9376	0.97620906866573	APOA1/SORBS1/ILK/FADS2/FABP5/HMGCS1/PPARD/PLIN1	-0.0723944059469933
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/1011	105/9376	0.971560454053036	RYR2/LMNA/ITGA1/SGCE/DMD/PRKACB/DAG1/ITGA3/SNTB1/TGFB2/SNTA1	-0.101878434003764
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1011	86/9376	0.97053343454558	RYR2/VAMP2/CREB5/CREB1/ATP1A1/PRKACB/ATP1B2/ATF6B/CAMK2D	-0.0954331217741647
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/1011	86/9376	0.97053343454558	RYR2/LMNA/ITGA1/SGCE/DMD/DAG1/ITGA3/SNTB1/SNTA1	-0.0954331217741647
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1011	191/9376	0.971098026421406	FOSB/CREB5/HAT1/HDAC5/CREB1/GNG12/HDAC2/PRKACB/BRAF/MAP2K1/GNG10/MAOA/ARAF/GNB2/SOS2/BDNF/MAPK1/KRAS/HRAS/ATF6B	-0.140291980542703
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1011	18/9376	1.03044290581383	NEU1/AGA	0.0449426916949318
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1011	28/9376	0.993641373463332	ELOVL1/HACD2/TECR	-0.0117141619880096
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1011	28/9376	0.993641373463332	PCBD1/PTS/MOCS2	-0.0117141619880096
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/1011	78/9376	0.95117806690507	SERPING1/FOS/IRF1/MAPK8/RELA/JUN/NFKB1/MAPK1	-0.150520532129371
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/1011	59/9376	0.943117235829603	MGST3/ODC1/PGD/MGST2/GSTM4/GPX4	-0.152369097028441
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1011	59/9376	0.943117235829603	AKT3/IRS1/PRKG1/PRKACB/PIK3CA/PLIN1	-0.152369097028441
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1011	30/9376	0.927398615232443	PIGC/PIGK/PGAP1	-0.138458903089918
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1011	20/9376	0.927398615232443	LBR/FDFT1	-0.112990788391043
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/1011	101/9376	0.918216450725191	WNT6/CREB1/PRKACB/MAP2K1/KITLG/MAPK1/WNT4/KRAS/HRAS/CAMK2D	-0.28727506091145
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1011	31/9376	0.897482530870106	H6PD/PGD/PGM2	-0.198754657080044
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	24/1011	238/9376	0.935191880906665	ISG15/FOS/IRF9/ADAR/MX1/RPL36AL/NFKBIA/CCL2/STAT1/MAPK8/RELA/IL6R/EIF2AK2/JUN/IFIH1/NFKB1/TAB2/OAS2/JAK1/RSL24D1/PIK3CA/MAPK1/TRAF3/RPS15	-0.352063143394106
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/1011	82/9376	0.90477913681214	MGST3/HPRT1/NME3/UPP1/MGST2/GSTM4/NME7/CDA	-0.301068937254278
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/1011	82/9376	0.90477913681214	HSPA1B/HSPA1A/B2M/CREB1/KLRC3/NFYB/TAPBP/HLA-E	-0.301068937254278
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/1011	103/9376	0.900387005080042	CXCL2/RELA/NFKB1/PRKACB/ACTN4/PIK3CA/ACTN1/LAMA3/LAMB2/TGFB2	-0.353388752945511
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/1011	63/9376	0.88323677641185	PLOD2/KMT2E/SETD7/NSD3/SETD2/SMYD3	-0.323265824048729
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/1011	155/9376	0.897482530870106	WNT6/NR4A1/CREB5/CREB1/LDLR/PRKACB/BRAF/MAP2K1/AIP/MAPK1/WNT4/ATF6B/CAMK2D/RAP1A/RBBP5	-0.447407188409156
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/1011	65/9376	0.856060260214563	NR4A1/CREB5/CREB1/LDLR/PRKACB/ATF6B	-0.404825137050409
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/1011	65/9376	0.856060260214563	AKT3/MAP2K1/PIK3CA/MAPK1/KRAS/HRAS	-0.404825137050409
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/1011	107/9376	0.86672767778733	CREB5/CREB1/AKT3/PPP4C/PRKACB/PPP3CC/PRKAA1/CAMK2D/ACACB/PRMT1	-0.481996246571287
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1011	12/9376	0.772832179360369	VKORC1L1	-0.273737927886862
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1011	12/9376	0.772832179360369	CD46	-0.273737927886862
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/1011	88/9376	0.843089650211312	SERPING1/CFH/PLAUR/CLU/CD46/SERPINE1/VTN/PROS1	-0.51411475308628
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1011	36/9376	0.772832179360369	GYG1/PGM2/PGM2L1	-0.474736766267329
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/1011	36/9376	0.772832179360369	GALNT1/B4GALT5/ST6GALNAC3	-0.474736766267329
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1011	36/9376	0.772832179360369	RNASEH2C/SSBP1/MCM3	-0.474736766267329
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1011	48/9376	0.772832179360369	ATP1A1/AKT3/ATP1B2/PIK3CA	-0.548531288412813
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1011	37/9376	0.75194482316144	ASL/NIT2/GLUD1	-0.525565940376935
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/1011	37/9376	0.75194482316144	PGM2/NANS/GNPNAT1	-0.525565940376935
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1011	70/9376	0.794913098770666	MGST3/EPHX1/MGST2/GSTM4/HSD11B1/CYP3A5	-0.598733643610865
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/1011	102/9376	0.818292895793332	RYR2/CPB1/ATP1A1/PLA2G2A/ATP1B2/ATP2B4/RAC1/ATP2B1/RAP1A	-0.641455732586452
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1011	26/9376	0.713383550178803	PLA2G2A/FADS2	-0.508756796703143
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1011	14/9376	0.662427582308888	B3GNT2	-0.439415019114926
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/1011	39/9376	0.713383550178803	MTHFD2/MAT2B/MTHFD2L	-0.623530899002701
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1011	51/9376	0.727371462927406	PLA2G2A/PAFAH1B3/PLD1/PLA2G7	-0.678672457002096
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/1011	116/9376	0.799481564855554	MDH1/MDH2/H6PD/PGD/CS/IDH3G/GLUD1/CAT/OGDH/ACO1	-0.755450566696305
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1011	15/9376	0.618265743488295	ST6GALNAC3	-0.514367932325902
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1011	15/9376	0.618265743488295	AK1	-0.514367932325902
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1011	28/9376	0.662427582308888	ATP6V1F/ATP6V0A1	-0.621891844207886
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/1011	63/9376	0.736030647009875	WNT6/BAX/GLI3/WNT4/GADD45B	-0.730814616072514
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/1011	75/9376	0.741918892185955	ASL/CS/IDH3G/MAT2B/ACO1/ACY1	-0.780099980623326
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/1011	75/9376	0.741918892185955	CREB5/CREB1/ATP1A1/PRKACB/ATP1B2/ATF6B	-0.780099980623326
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/1011	41/9376	0.678584352609105	SEM1/SSBP1/BABAM1	-0.717017946878917
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	30/1011	323/9376	0.86136094294035	MMP9/THBS1/FOXP1/PDGFA/ROCK1/BCL2/HDAC5/MYC/SOX4/NOTCH3/PIM1/IRS1/HDAC2/RPS6KA5/ZEB2/NFKB1/BMPR2/MAP2K1/SLC7A1/HOXD10/CRK/SOS2/PIK3CA/MAPK1/KRAS/HRAS/NOTCH1/TGFB2/MTOR/RECK	-0.881492943867942
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1011	16/9376	0.579624134520277	MAOA	-0.585043400570409
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1011	16/9376	0.579624134520277	GLA	-0.585043400570409
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1011	42/9376	0.662427582308888	MAOA/KYAT3/CAT	-0.762229836063219
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/1011	30/9376	0.618265743488295	RELA/NFKB1	-0.728009618517291
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1011	17/9376	0.545528597195555	CYP7B1	-0.651995414342116
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1011	17/9376	0.545528597195555	KYAT3	-0.651995414342116
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1011	17/9376	0.545528597195555	GLUD1	-0.651995414342116
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1011	43/9376	0.647022289697053	APOA1/DGAT1/PLA2G2A	-0.806490247086459
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/1011	89/9376	0.729414641194056	THBS1/ITGA1/DAG1/LAMA3/VTN/ITGA3/LAMB2	-0.89164056297196
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/1011	89/9376	0.729414641194056	GNG12/PRKACB/GABARAPL2/GNG10/HAP1/SLC6A1/GNB2	-0.89164056297196
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1011	79/9376	0.704353378657552	MGST3/EPHX1/MGST2/GSTM4/HSD11B1/CYP3A5	-0.917367380924612
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1011	18/9376	0.515221452906913	ACACB	-0.715675859445287
NA	NA	hsa04081	Hormone signaling	19/1011	219/9376	0.804592405909425	PRL/GNG12/SMAD4/IRS1/SLC40A1/ESR1/IGF1R/AVPR1A/SSTR2/PRKG1/PRKACB/GHR/GNG10/THRA/ADIPOR1/GNB2/PIK3CA/ADRA2A/PRLR	-1.0172205641382
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1011	32/9376	0.579624134520277	GLA/PGM2	-0.828084378812105
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/1011	57/9376	0.650806045777153	ELOVL1/HACD2/FADS2/TECR	-0.919279829829918
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1011	19/9376	0.488104534332865	OGDH	-0.776458076461013
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/1011	59/9376	0.628744823886402	NME3/UPP1/NME7/CDA	-0.994463204743538
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/1011	47/9376	0.591956562914325	MDH1/MDH2/ACACB	-0.974913362208447
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1011	73/9376	0.635204530981125	MGST3/MAOA/MGST2/GSTM4/CYP3A5	-1.08774625921091
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	12/1011	155/9376	0.717986024696085	THBS1/TUBA1A/ATP6V1F/MRC2/SEC61G/ATP6AP1/STX12/DYNC1LI2/ATP6V0A1/RAC1/HLA-E/PIK3C3	-1.23076662790948
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1011	22/9376	0.421544825105656	MAOA	-0.944301352295787
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/1011	37/9376	0.501296548774294	APOA1/ICAM1	-1.05662599609136
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/1011	99/9376	0.655736394608798	NGF/MAPK8/MAP2K3/PRKACB/IL1RAP/PIK3CA/CAMK2D	-1.19710756433572
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/1011	76/9376	0.610130667916081	ATP1A1/SSTR2/PRKACB/ATP1B2/CAMK2D	-1.18634946638301
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	21/1011	254/9376	0.7667468866095	NFATC2/PDE1A/RYR2/PDGFA/PLCE1/NGF/SLC25A5/NFATC1/MCU/NTRK3/CAMK1D/AVPR1A/PRKACB/SPHK1/PPP3CC/VDAC2/SLC25A4/ATP2B4/ATP2B1/CAMK2D/PDGFC	-1.31016959624772
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/1011	38/9376	0.488104534332865	PGM2/GNPNAT1	-1.09919410217482
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1011	23/9376	0.403216789231497	LARGE1	-0.996169615098937
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1011	23/9376	0.403216789231497	SSBP1	-0.996169615098937
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/1011	52/9376	0.535037662634102	IGF1R/LDLR/PRKACB	-1.1688171048008
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1011	66/9376	0.562059766807541	CYP7B1/HSD17B11/HSD11B1/CYP3A5	-1.24119556729767
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/1011	160/9376	0.695548961424332	ICAM1/ALCAM/SDC2/GLG1/ESAM/NFASC/CD58/NRXN3/NECTIN2/HLA-E/CLDN4/SELPLG	-1.35031303959626
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/1011	91/9376	0.611471614438973	PDE1A/PDE3A/GNG12/PRKACB/GNG10/GNB2	-1.29473455492339
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/1011	195/9376	0.713383550178803	HAT1/HDAC5/SLC25A5/AKT3/RELA/HDAC2/NFKB1/MAP2K1/VDAC2/SLC25A4/RAC1/PIK3CA/MAPK1/MTOR/SELPLG	-1.40605292318845
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1011	27/9376	0.343480968604609	HMGCS1	-1.18761278872367
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1011	28/9376	0.331213791154444	B3GNT2	-1.23206952642776
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1011	99/9376	0.562059766807541	ICAM1/KRT23/CFH/KRT18/KRT10/SELPLG	-1.52284922853201
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/1011	100/9376	0.556439169139466	ITGA1/CD9/IL6R/CSF1/ITGA3/KITLG	-1.55024757857725
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1011	30/9376	0.309132871744148	PLA2G2A	-1.31756033394466
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/1011	48/9376	0.386416089680185	HMGCS1/HIBADH	-1.48159176739658
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/1011	90/9376	0.515221452906913	ATP1A1/LDLR/PRKACB/ATP1B2/EPHX1	-1.60649194064146
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/1011	116/9376	0.559637095398888	GNG12/PRKACB/GNG10/PPP3CC/GNB2/PLD1/MAPK1	-1.65906145035142
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/1011	32/9376	0.289812067260138	ACACB	-1.39897549173433
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/1011	49/9376	0.37853004703365	GALNT1/EOGT	-1.5162661200117
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/1011	154/9376	0.60220689300808	MTHFD2/NME3/VKORC1L1/PTS/MOCS2/AK1/NME7/MAT2B/UROD/MTHFD2L	-1.73034737388591
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/1011	50/9376	0.370959446092977	ODC1/MAOA	-1.55040151839226
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1011	50/9376	0.370959446092977	LTBR/CCR10	-1.55040151839226
NA	NA	hsa04382	Cornified envelope formation	15/1011	217/9376	0.641058950621505	UGCG/KRT23/PPP2R2A/PPP2CA/KRT18/KRT10/TJP1/PPP2R2D/ELOVL1/PPP2R5E/PPP2R1A/LAMA3/PPP2R3C/CLDN4/S100A1	-1.8597613117066
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1011	36/9376	0.257610726453456	DCXR	-1.55144985783058
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1011	37/9376	0.250648274387147	MAOA	-1.58768605180578
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1011	39/9376	0.237794516726267	HLA-E	-1.65816955205099
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/1011	103/9376	0.450193502540021	CPB1/ATP1A1/COL14A1/ATP1B2/COL12A1	-1.95050287018118
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1011	41/9376	0.226194784203035	MAOA	-1.72621411439926
Genetic Information Processing	Translation	hsa03010	Ribosome	14/1011	222/9376	0.584845973570009	RPL36AL/MRPS18C/MRPS11/MRPL42/MRPS28/MRPL50/MRPL4/RSL24D1/MRPL16/MRPS7/MRPL12/MRPL37/RPS15/MRPL38	-2.17624873094719
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/1011	43/9376	0.215674096565684	ECI1	-1.79204287747846
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/1011	44/9376	0.210772412552828	APEX1	-1.82418749445302
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/1011	44/9376	0.210772412552828	HLA-E	-1.82418749445302
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/1011	63/9376	0.29441225880395	PLA2G2A/GPX4	-1.95346099214387
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/1011	45/9376	0.206088581162765	ABCD3	-1.85584821693515
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1011	45/9376	0.206088581162765	HLA-E	-1.85584821693515
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/1011	46/9376	0.201608394615748	UROD	-1.88704518441268
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/1011	83/9376	0.335204318758714	CAT/PEX11B/ABCD3	-2.11483997257157
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1011	68/9376	0.272764298597777	DGAT1/CYP3A5	-2.09232769438185
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1011	86/9376	0.323511144848527	PDE1A/PRKACB/ENTPD2	-2.1909388589043
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/1011	54/9376	0.171740484302304	HLA-E	-2.12195909649857
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	9/1011	183/9376	0.456097679622513	NXT1/RRP7A/NOP10/NOP56/SBDS/IMP4/NMD3/XRN2/POP5	-2.58312884897729
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/1011	67/9376	0.138417703766036	PGM2	-2.46042933332621
NA	NA	hsa04082	Neuroactive ligand signaling	7/1011	199/9376	0.326220618423472	GNG12/PRKACB/GNG10/SLC6A1/GNB2/ACHE/ADRA2A	-3.33981286000753
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/1011	143/9376	0.12970610003251	ACTN4/ACTN1	-3.64578273360543
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/1011	370/9376	0.250648274387147	PRL/NR3C1/AVPR1A/RXFP1/SSTR2/GHR/THRA/GAL/ADRA2A/PRLR	-5.11268276061011
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1011	449/9376	0.12392854546536	PDE1A/OR51E1/PRKG1/PRKACB/NCALD/CAMK2D	-6.61360383109652