category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	80/1300	250/9376	2.30793846153846	ACP5/GLA/OSBPL3/DMXL2/NPC2/AP1S2/GPR155/VAMP8/ASAH1/ATP6V1F/CTSD/ATP6V0C/CTSK/CD68/VPS41/PSAP/CTSW/CTSC/BORCS7/ATP6AP1/MAN2B1/ATP6V1A/CTSH/DMXL1/WDR7/OSBPL1A/VPS13C/TLR7/TPP1/TCIRG1/GNPTAB/DEPTOR/ATP6V0D2/MANBA/SUMF1/DNASE2/CTSZ/ATP6V0B/TLR3/AP2A2/IDS/HEXB/GAA/HEXA/BORCS5/AGA/GNPTG/SLC38A9/GGA1/FUCA1/CTSA/ARSB/ATP6V1C1/LAMTOR4/MITF/OSTM1/NEU1/KXD1/GM2A/CLCN7/LGMN/ATP6V0E1/ACP2/MFSD8/SLC15A4/AP1S3/ATP6V1G1/AP5M1/ATP6V0A1/ABCA5/FIG4/ATP6V1B2/BLOC1S5/VAMP7/BORCS8/ROGDI/OSBPL7/AP4E1/LITAF/SLC29A1	8.40961748662016
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	61/1300	173/9376	2.54306803023566	MX1/DNAJB1/CCND3/EIF2AK2/MX2/IRF7/HLA-DPA1/HLA-DQA1/OAS2/OAS1/IFIH1/NFKB1/RSAD2/ICAM1/PYCARD/STAT1/CIITA/IRF9/HLA-DMA/HLA-DMB/STAT2/HLA-DRB1/HLA-DRA/OAS3/JAK2/TLR7/ADAR/TNFSF10/HLA-DPB1/PML/IL18/CYCS/TLR3/IKBKB/CCL2/CXCL10/SLC25A5/KPNA1/APAF1/CASP1/NUP98/NXT1/NFKBIB/IFNGR1/TNFRSF10B/NFKBIA/PIK3CB/PABPN1/CCL5/IRAK4/PIK3CD/CDK6/IL1A/TICAM1/RAB11B/IL1B/HLA-DQB2/TNFRSF10A/RAB11A/SLC25A4/IFNG	8.21868950099447
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	41/1300	95/9376	3.11268016194332	FOS/ACP5/HLA-DPA1/HLA-DQA1/TNFSF13B/JUN/ICAM1/TLR2/ATP6V1F/ATP6V0C/CTSK/CD86/HLA-DMA/ATP6AP1/HLA-DMB/ATP6V1A/HLA-DRB1/HLA-DRA/CCL3/TCIRG1/HLA-DPB1/ATP6V0D2/IL18/ATP6V0B/CCL2/ATP6V1C1/CXCL3/TGFB2/CCL5/ATP6V0E1/TNFSF13/CXCL2/IL1A/ATP6V1G1/IL1B/ATP6V0A1/HLA-DQB2/ATP6V1B2/TNFRSF11A/LTB/IFNG	8.30342619581869
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	58/1300	180/9376	2.32396581196581	B2M/HLA-A/CD74/BST2/EIF2AK2/IRF7/HLA-DPA1/HLA-DQA1/OAS2/OAS1/IFIH1/C3/NFKB1/BIRC3/TLR2/STAT1/SP100/IRF9/ZC3HAV1/HLA-DMA/HLA-DMB/STAT2/HLA-DRB1/HLA-DRA/OAS3/JAK2/HLA-E/HLA-DPB1/PML/EIF4EBP1/POU2F1/CYCS/TLR3/IKBKB/PPP1CB/TNFRSF14/PPP1CC/CCL2/CGAS/NECTIN2/APAF1/HLA-C/IFNGR1/BIRC2/NFKBIA/PIK3CB/CCL5/SRSF7/TRAF6/IRAK4/PIK3CD/TICAM1/ITGB3/IL1B/HLA-DQB2/EIF2B5/C5/IFNG	7.19569424303291
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	58/1300	181/9376	2.31112622184445	CD74/HSPD1/HLA-DPA1/HLA-DQA1/C3/RIPK2/NFKB1/CREB1/TLR2/STAT1/CTSD/ATP6V0C/CIITA/HLA-DMA/ATP6AP1/MALT1/HLA-DMB/PPP3CA/HLA-DRB1/HLA-DRA/JAK2/CLEC7A/TCIRG1/HLA-DPB1/ATP6V0D2/CORO1A/IL10/IL18/RHOA/CYCS/ATP6V0B/FCGR2A/FCGR2B/APAF1/CAMK2D/IFNGR1/IL10RA/MAPK8/TGFB2/FCER1G/TLR6/TRAF6/IRAK4/IL1A/CLEC4E/CALM2/CAMP/CR1L/CAMK2G/IL1B/ATP6V0A1/MRC1/HLA-DQB2/CEBPG/SPHK1/NOD2/IFNG/RFX5	7.1460669879529
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	49/1300	142/9376	2.48875406283857	FOS/ACP5/TYROBP/JUNB/FOSB/NCF1/NFKB1/JUN/CREB1/STAT1/SPI1/JUND/TREM2/CTSK/IRF9/SQSTM1/TGFBR1/PLCG2/FOSL2/STAT2/PPP3CA/LCP2/TEC1/CYBA/BLNK/NCF4/IKBKB/FCGR2A/FCGR2B/NFKB2/LILRA2/IFNGR1/MITF/NFKBIA/PIK3CB/MAPK8/TGFB2/GAB2/MAP3K14/MAP2K6/TRAF6/PIK3CD/IL1A/ITGB3/IL1B/TNFRSF11A/CALCR/OSCAR/IFNG	7.17185261449336
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	58/1300	187/9376	2.23697243932538	NAMPT/HSP90AA1/IRF7/OAS2/OAS1/RIPK2/NFKB1/JUN/BIRC3/TANK/TNFAIP3/PYCARD/STAT1/PKN2/TXNIP/GPSM3/IRF9/GBP4/STAT2/TRPM2/OAS3/NLRP1/CARD8/NEK7/ATG5/IL18/RHOA/CYBA/GSDMD/IKBKB/PSTPIP1/CCL2/ANTXR2/GABARAP/CASP1/HSP90AB1/CARD16/NFKBIB/CXCL3/BIRC2/NFKBIA/MAPK8/CCL5/CARD6/PLCB2/TRAF6/IRAK4/CXCL2/TRPV2/TICAM1/CAMP/IL1B/BRCC3/AIM2/RNF31/NOD2/MEFV/RIPK3	6.85497475992365
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	32/1300	78/9376	2.95889546351085	FOS/HLA-DPA1/HLA-DQA1/NCF1/C3/NFKB1/JUN/TLR2/STAT1/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/JAK2/HLA-DPB1/IL10/ITGA4/CYBA/NCF4/FCGR2A/NFKBIB/IFNGR1/NFKBIA/TGFB2/TRAF6/IRAK4/IL1A/CR1L/IL1B/HLA-DQB2/PTGS2/IFNG	6.96984227238818
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	33/1300	82/9376	2.90251407129456	HSP90AA1/HSPA1B/HSPA1A/B2M/HLA-A/CD74/KLRC1/HLA-DPA1/HLA-DQA1/IFI30/CREB1/KLRC3/CIITA/KLRC2/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/KLRD1/HLA-E/HLA-DPB1/KIR2DL4/HSP90AB1/HLA-C/LGMN/KLRC4/HLA-DQB2/HSPA8/HSPA1L/KIR2DL3/KIR3DL2/IFNG/RFX5	6.94212819032859
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	39/1300	109/9376	2.5805504587156	HSP90AA1/FOS/AHR/HLA-DPA1/HLA-DQA1/NFKB1/JUN/STAT1/IL1RAP/CD247/HLA-DMA/TGFBR1/HLA-DMB/PPP3CA/HLA-DRB1/HLA-DRA/JAK2/IL2RB/NFKBIE/HLA-DPB1/HIF1A/IKBKB/NFATC3/LAT/RUNX1/HSP90AB1/NFKBIB/IFNGR1/NFKBIA/MAPK8/ZAP70/CD3E/IL21R/GATA3/IL1B/HLA-DQB2/IL12RB1/IL27RA/IFNG	6.65903337883565
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	62/1300	216/9376	2.07019943019943	APOA1/MMP9/HSP90AA1/HSPA1B/HSPA1A/FOS/HSPD1/LY96/IRF7/NCF1/NFKB1/JUN/ICAM1/TANK/TLR2/PYCARD/NFE2L2/OLR1/LYN/VAV3/PPP3CA/ATF6/JAK2/CCL3/TNFSF10/POU2F1/IL18/RHOA/CYBA/CYCS/NCF4/IKBKB/KRAS/CCL2/RAP1A/NFATC3/APAF1/VAV1/CAMK2D/CASP1/HSP90AB1/CXCL3/TNFRSF10B/NFKBIA/PIK3CB/MAPK8/CCL5/MAP2K6/PLCB2/TLR6/TRAF6/IRAK4/CXCL2/PIK3CD/TICAM1/CALM2/CAMK2G/IL1B/TNFRSF10A/CD40/HSPA8/HSPA1L	6.3841489836065
Human Diseases	Infectious disease: viral	hsa05162	Measles	43/1300	136/9376	2.28036199095023	HSPA1B/HSPA1A/FOS/MX1/CCND3/EIF2AK2/MX2/IRF7/OAS2/OAS1/IFIH1/NFKB1/JUN/TLR2/TNFAIP3/STAT1/IRF9/STAT2/OAS3/IL2RB/TLR7/ADAR/CD46/CYCS/CDKN1B/IKBKB/FCGR2B/APAF1/NFKBIB/NFKBIA/PIK3CB/MAPK8/CD3E/TRAF6/IRAK4/PIK3CD/RCHY1/CDK6/IL1A/IL1B/HSPA8/HSPA1L/BBC3	6.03427920338362
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	57/1300	205/9376	2.00537335834897	ISG15/B2M/HLA-A/CCND3/EIF2AK2/IRF7/HLA-DPA1/HLA-DQA1/OAS2/OAS1/NFKB1/JUN/ICAM1/TLR2/TNFAIP3/STAT1/CD58/SAP30/LYN/CD247/IRF9/RUNX3/HLA-DMA/GADD45B/HLA-DMB/PLCG2/STAT2/HLA-DRB1/HLA-DRA/OAS3/HLA-E/RB1/NFKBIE/HLA-DPB1/BLNK/CYCS/ENTPD1/CDKN1B/IKBKB/CXCL10/APAF1/NFKB2/HLA-C/NFKBIB/NFKBIA/PIK3CB/MAPK8/MAP3K14/MAP2K6/CD3E/TRAF6/IRAK4/PIK3CD/CDK6/DDB2/HLA-DQB2/CD40	5.83922373014029
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	21/1300	45/9376	3.36574358974359	HLA-A/KLRC1/GZMB/HLA-DPA1/HLA-DQA1/CD86/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/PRF1/KLRD1/HLA-E/HLA-DPB1/HLA-C/IL1A/IL1B/HLA-DQB2/KIR2DL3/KIR3DL2/IFNG	6.38217918759267
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	33/1300	93/9376	2.55920595533499	FOS/MAML3/STAT4/HLA-DPA1/HLA-DQA1/NFKB1/JUN/STAT1/CD247/RUNX3/HLA-DMA/HLA-DMB/PPP3CA/HLA-DRB1/HLA-DRA/JAK2/IL2RB/NFKBIE/HLA-DPB1/IKBKB/NFATC3/LAT/NFKBIB/IFNGR1/NFKBIA/MAPK8/ZAP70/CD3E/MAF/GATA3/HLA-DQB2/IL12RB1/IFNG	6.06261435029152
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	35/1300	103/9376	2.45078416728902	FOS/C1QB/C3/NFKB1/JUN/TLR2/CD247/TGFBR1/C1QA/CCL3/SERPINE1/IL10/GNAQ/C1QC/IKBKB/CCL2/GNAS/PPP2R2A/GNA15/IFNGR1/NFKBIA/PIK3CB/MAPK8/TGFB2/CCL5/CD3E/PPP2R2B/PLCB2/TLR6/TRAF6/IRAK4/PIK3CD/TICAM1/IL1B/IFNG	5.93978122221612
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	26/1300	66/9376	2.84121212121212	STAT4/HLA-DPA1/HLA-DQA1/NFKB1/JUN/TLR2/STAT1/HLA-DMA/HLA-DMB/TLR5/HLA-DRB1/HLA-DRA/HLA-DPB1/IL10/IL18/IFNGR1/TGFB2/IL21R/MAF/GATA3/IL1A/IL1B/HLA-DQB2/NOD2/IL12RB1/IFNG	6.02226846377487
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	35/1300	105/9376	2.40410256410256	LY96/TNFSF13B/NFKB1/BIRC3/ICAM1/TNFAIP3/LYN/ATM/CCL4/GADD45B/MALT1/PLCG2/CARD11/EDA/ERC1/BLNK/IKBKB/PLAU/LAT/NFKB2/CXCL3/BIRC2/NFKBIA/MAP3K14/ZAP70/TRAF6/IRAK4/CXCL2/TICAM1/IL1B/PTGS2/CD40/TNFRSF11A/CCL21/LTB	5.80482792983338
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	42/1300	138/9376	2.19505016722408	FOS/FYB1/NFKB1/JUN/SKAP2/ELMO1/PYCARD/PKN2/VAV3/RAC2/GIT2/LCP2/WAS/RHOG/IL10/GNAQ/IL18/ITGA4/RPS6KA2/RHOA/IKBKB/ARPC3/CCL2/FCGR2A/WIPF1/NFATC3/LAT/VAV1/CASP1/ARPC1B/NFKBIA/PIK3CB/MAPK8/MAP2K6/ZAP70/ARHGEF7/TRAF6/IRAK4/PIK3CD/TICAM1/IL1B/MEFV	5.67408530110247
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	20/1300	44/9376	3.27832167832168	HLA-A/GZMB/HSPD1/HLA-DPA1/HLA-DQA1/CD86/HLA-DMA/ICA1/HLA-DMB/HLA-DRB1/HLA-DRA/PRF1/HLA-E/HLA-DPB1/HLA-C/IL1A/IL1B/HLA-DQB2/PTPRN/IFNG	6.07733497694222
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	36/1300	112/9376	2.31824175824176	HSPA1B/HSPA1A/LY96/HLA-DPA1/HLA-DQA1/NFKB1/BIRC3/TLR2/STAT1/CIITA/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/JAK2/ALOX5/HLA-DPB1/ITGA6/IL10/CYCS/IKBKB/NFKBIB/IFNGR1/BIRC2/IL10RA/NFKBIA/MAPK8/TGFB2/MAP2K6/TRAF6/IRAK4/HLA-DQB2/CD40/HSPA8/HSPA1L/IFNG	5.63072039547231
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	26/1300	71/9376	2.64112676056338	NFKB1/JUN/PAK1/ATP6V1F/ATP6V0C/LYN/ATP6AP1/PLCG2/F11R/ATP6V1A/TCIRG1/ATP6V0D2/ATP6V0B/IKBKB/ATP6V1C1/CXCL3/NFKBIA/MAPK8/CCL5/MAP3K14/ATP6V0E1/CXCL2/CSK/ATP6V1G1/ATP6V0A1/ATP6V1B2	5.56893657976839
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	39/1300	133/9376	2.11488721804511	HLA-A/TYROBP/KLRC1/GZMB/ICAM1/PAK1/KLRC3/CD247/VAV3/KLRC2/RAC2/PLCG2/PPP3CA/KLRK1/LCP2/PRF1/KLRD1/HLA-E/BRAF/TNFSF10/LAT2/KRAS/LAT/VAV1/KIR2DL4/HLA-C/IFNGR1/TNFRSF10B/CD48/PIK3CB/ZAP70/FCER1G/PIK3CD/SH2D1B/TNFRSF10A/KIR2DL3/KIR3DL2/NCR1/IFNG	5.1952857506038
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	51/1300	196/9376	1.87667189952904	FOS/ZFP36/HLA-A/EIF2AK2/IRF7/C3/NFKB1/JUN/CREB1/ICAM1/STAT1/GNB4/CD86/LYN/IRF9/PLCG2/STAT2/PPP3CA/JAK2/HLA-E/RB1/HIF1A/CYCS/TLR3/IKBKB/KRAS/ATG3/NFATC3/ATG14/PREX1/HLA-C/CXCL3/IFNGR1/GNG2/NFKBIA/PIK3CB/MAPK8/MAP2K6/CTNNB1/HCK/CXCL2/PIK3CD/CDK6/UBA52/TICAM1/CALM2/PDGFB/PTGS2/GNGT2/LEF1/CLEC2B	4.97625859126239
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	56/1300	224/9376	1.80307692307692	FOS/ZFP36/B2M/HLA-A/CCND3/HLA-DPA1/HLA-DQA1/NFKB1/JUN/CREB1/ICAM1/SPI1/EGR2/ATM/HLA-DMA/TGFBR1/HLA-DMB/PPP3CA/HLA-DRB1/HLA-DRA/IL2RB/HLA-E/DLG1/RB1/TSPO/KAT2B/ANAPC16/HLA-DPB1/IKBKB/MAP3K1/KRAS/ATR/NFATC3/SLC25A5/IL1R2/NFKB2/CDC27/HLA-C/NFKBIA/MAP3K3/TLN2/PIK3CB/MAPK8/CDKN2A/TGFB2/ADCY7/MAP3K14/POLB/GPS2/CD3E/PIK3CD/HLA-DQB2/CD40/SLC25A4/EGR1/CRTC2	4.88070219308127
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	36/1300	122/9376	2.12822194199243	FOS/PTPRC/NCK1/NFKB1/JUN/PAK1/CD247/VAV3/PPP2R5E/MALT1/PPP3CA/CARD11/LCP2/DLG1/NFKBIE/PPP2R5C/ITK/IL10/TEC1/RHOA/IKBKB/KRAS/NFATC3/LAT/VAV1/PPP2R2A/NFKBIB/NFKBIA/PIK3CB/MAPK8/MAP3K14/ZAP70/CD3E/PPP2R2B/PIK3CD/IFNG	5.03232717351272
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	50/1300	193/9376	1.8684734954165	CXCR4/NCF1/NFKB1/ELMO1/STAT1/PAK1/GRK3/GNB4/RASGRP2/LYN/XCL2/CCL8/VAV3/RAC2/CCL4/PLCG2/STAT2/XCL1/JAK2/CCL3/WAS/BRAF/ITK/CXCL16/GNAQ/RHOA/IKBKB/ARRB2/KRAS/CCL2/CXCL10/RAP1A/VAV1/TIAM1/PREX1/NFKBIB/CXCL3/GNG2/NFKBIA/PIK3CB/ADCY7/CCL5/PLCB2/HCK/CXCL2/PIK3CD/CCL23/CXCR3/GNGT2/CCL21	4.89104986446097
Human Diseases	Immune disease	hsa05330	Allograft rejection	17/1300	39/9376	3.14382642998028	HLA-A/GZMB/HLA-DPA1/HLA-DQA1/CD86/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/PRF1/HLA-E/HLA-DPB1/IL10/HLA-C/HLA-DQB2/CD40/IFNG	5.38241777626488
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	21/1300	56/9376	2.70461538461538	HSPA1B/HSPA1A/HSPD1/C3/NFKB1/TLR2/PYCARD/TLR5/IL18/CYCS/SEC22B/APAF1/NFKB2/CASP1/CXCL3/NFKBIA/CXCL2/CR1L/IL1B/HSPA8/HSPA1L	5.13300420800891
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	42/1300	155/9376	1.95430272952854	HLA-A/HLA-DPA1/MSR1/HLA-DQA1/NCF1/C3/TLR2/ATP6V1F/ATP6V0C/STX7/OLR1/HLA-DMA/ATP6AP1/HLA-DMB/ATP6V1A/HLA-DRB1/HLA-DRA/CLEC7A/HLA-E/TCIRG1/HLA-DPB1/ATP6V0D2/CORO1A/CYBA/ATP6V0B/NCF4/SEC22B/FCGR2A/FCGR2B/ITGA2/ATP6V1C1/HLA-C/ATP6V0E1/TLR6/ATP6V1G1/ITGB3/ATP6V0A1/RILP/MRC1/HLA-DQB2/ATP6V1B2/TUBA3E	4.80642492676995
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	27/1300	83/9376	2.34617238183503	IRF7/NFKB1/PYCARD/CCL4/POLR3GL/ADAR/DNASE2/IL18/POLR2K/GSDMD/IKBKB/CGAS/CXCL10/ZBP1/MLKL/CASP1/NFKBIB/NFKBIA/CCL5/POLR3K/POLR3C/IL1B/GSDME/AIM2/MEFV/RIPK3/POLR3B	4.94220679103506
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	28/1300	90/9376	2.24382905982906	FOS/NFKB1/JUN/TLR2/STAT1/CD247/PPP3CA/JAK2/NFKBIE/HIF1A/IKBKB/KRAS/NFATC3/LAT/NFKBIB/IFNGR1/NFKBIA/MAP3K3/PIK3CB/MAP2K6/ZAP70/CD3E/TRAF6/PIK3CD/TICAM1/RPS6KB2/BATF2/IFNG	4.7569301392822
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	31/1300	105/9376	2.12934798534799	NFKB1/JUN/PYCARD/STAT1/PAK1/EGR2/IRF9/MALT1/PLCG2/STAT2/PPP3CA/CLEC7A/BCL3/IL10/RHOA/IKBKB/KRAS/NFATC3/NFKB2/CASP1/NFKBIA/PIK3CB/MAPK8/MAP3K14/FCER1G/PIK3CD/CLEC4E/CALM2/IL1B/PTGS2/EGR3	4.66894007279242
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	38/1300	142/9376	1.93005417118093	KLF2/MMP9/HSP90AA1/FOS/DUSP1/MEF2C/MEF2A/NCF1/NFKB1/JUN/ICAM1/NFE2L2/HMOX1/RAC2/SQSTM1/MGST2/PECAM1/RHOA/CYBA/IKBKB/CCL2/MAP2K5/IL1R2/HSP90AB1/PIK3CB/MAPK8/ACVR2A/MAP2K6/CTNNB1/SDC1/PIK3CD/IL1A/CALM2/ITGB3/IL1B/PDGFB/KDR/IFNG	4.48039847930725
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	10/1300	18/9376	4.00683760683761	MAN2B1/MANBA/HEXB/HEXA/AGA/FUCA1/HEXD/NEU1/MAN2C1/NEU3	5.12287624626672
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	31/1300	109/9376	2.0512067748765	FOS/LY96/IRF7/NFKB1/JUN/TLR2/STAT1/CTSK/CD86/IRF9/CCL4/STAT2/TLR5/CCL3/TLR7/TLR3/IKBKB/CXCL10/NFKBIA/PIK3CB/MAPK8/CCL5/MAP2K6/TLR6/TRAF6/IRAK4/PIK3CD/TICAM1/IL1B/IRF5/CD40	4.42885006509012
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	40/1300	156/9376	1.84930966469428	MX1/EIF2AK2/IFIT1/MX2/IRF7/OAS2/OAS1/NFKB1/RSAD2/STAT1/YWHAZ/YWHAH/IRF9/STAT2/OAS3/RB1/PIAS1/BRAF/CYCS/TLR3/IKBKB/KRAS/CXCL10/APAF1/PPP2R2A/EIF3E/NFKBIA/PIK3CB/CTNNB1/CD81/PPP2R2B/TRAF6/PIK3CD/CLDN4/CDK6/TICAM1/CLDN20/CLDN1/IFNG/CLDN10	4.2916279398482
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	18/1300	50/9376	2.59643076923077	ICAM1/TLR2/KLRB1/KLRK1/GYPC/PECAM1/IL10/IL18/CCL2/HGF/TGFB2/CD81/SDC1/CR1L/IL1B/CD40/IFNG/ACKR1	4.54094817606336
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	28/1300	100/9376	2.01944615384615	CD37/HLA-DPA1/HLA-DQA1/ITGA1/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/CD7/HLA-DPB1/ITGA6/CD22/ITGA4/CSF2RA/IL1R2/ITGA2/CD33/CD38/CD3E/IL7/IL1A/ANPEP/ITGB3/CR1L/IL1B/HLA-DQB2/ITGA3/CD59	4.11190508166767
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	41/1300	168/9376	1.76014652014652	HSP90AA1/FTH1/EIF2AK2/STAT4/BIRC3/TNFAIP3/PYCARD/STAT1/PLA2G4A/PLA2G4C/IRF9/SQSTM1/STAT2/JAK2/CHMP5/TNFSF10/TLR3/ZBP1/SLC25A5/CHMP1B/MLKL/CAMK2D/CASP1/HSP90AB1/GLUL/IFNGR1/TNFRSF10B/BIRC2/MAPK8/GLUD1/IL1A/TICAM1/CAMK2G/IL1B/TNFRSF10A/CHMP7/SLC25A4/RNF31/RIPK3/IFNG/SPATA2L	3.98867321212178
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	26/1300	91/9376	2.06065934065934	FOS/NFKB1/INPP5D/JUN/LYN/VAV3/RAC2/MALT1/PLCG2/PPP3CA/CARD11/NFKBIE/CD22/BLNK/IKBKB/KRAS/FCGR2B/NFATC3/VAV1/DAPP1/LILRA2/NFKBIB/NFKBIA/PIK3CB/CD81/PIK3CD	4.07910441434382
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	55/1300	248/9376	1.59950372208437	HSP90AA1/FOS/RHOB/PTPRC/LY96/RIPK2/NFKB1/JUN/BIRC3/ELMO1/TLR2/PYCARD/PAK1/DYNLRB1/VPS41/TLR5/RHOG/TNFSF10/PIK3C2A/RHOH/IL18/RHOA/CYCS/GSDMD/IKBKB/ARPC3/KPNA1/MLKL/DCTN4/CASP1/HSP90AB1/ARPC1B/TNFRSF10B/PFN1/BIRC2/NFKBIA/PIK3CB/EXOC2/MAPK8/MAP2K6/SNX18/CTNNB1/CSE1L/TLR6/TRAF6/IRAK4/PIK3CD/S100A10/IL1B/RILP/TNFRSF10A/CYTH2/LEF1/TUBA3E/RIPK3	3.83874326714694
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	17/1300	50/9376	2.45218461538462	CXCR4/HLA-DPA1/HLA-DQA1/TNFSF13B/CD86/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/HLA-DPB1/IL10/ITGA4/MAP3K14/TNFSF13/ICOSLG/HLA-DQB2/CD40	4.13064894991686
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	23/1300	78/9376	2.12670611439842	FOS/LY96/C1QB/C3/NFKB1/JUN/PYCARD/C1QA/SERPING1/IL10/RHOA/C1QC/CASP1/C2/MAPK8/TRAF6/IRAK4/IL1A/TICAM1/CALM2/IL1B/IRF8/C5	4.00887339369188
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	27/1300	98/9376	1.98706436420722	PTPRC/NCF1/INPP5D/PAK1/PLA2G4A/PLA2G4C/LYN/VAV3/RAC2/PLCG2/WAS/MARCKS/ARPC3/FCGR2A/PLD1/FCGR2B/LAT/SCIN/VAV1/ARPC1B/PIK3CB/GAB2/LIMK2/HCK/PIK3CD/RPS6KB2/SPHK1	3.94085527409153
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	22/1300	75/9376	2.11561025641026	CCND3/IGFBP3/ATM/GADD45B/SERPINE1/PMAIP1/CDK1/COP1/CYCS/RRM2B/ATR/IGF1/SESN1/APAF1/ZMAT3/TNFRSF10B/CDKN2A/RCHY1/CDK6/DDB2/TNFRSF10A/BBC3	3.89168308775903
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	63/1300	300/9376	1.51458461538462	HSPA1B/HSPA1A/FOS/DUSP1/MEF2C/NR4A1/PDGFC/RASA2/TAOK3/NFKB1/JUN/PAK1/IL1RAP/PLA2G4A/JUND/PLA2G4C/RASA1/RASGRP2/RAC2/GADD45B/TGFBR1/PPP3CA/MAP3K2/NLK/BRAF/MAP4K3/RPS6KA2/IKBKB/DUSP6/ARRB2/MAP3K1/KRAS/NF1/MAP2K5/RAP1A/NFATC3/IGF1/HGF/NFKB2/MAP3K3/DUSP3/MAPK8/TGFB2/MAP3K14/MAP4K4/MAP2K6/TRAF6/IRAK4/IL1A/PDGFD/CACNB4/IL1B/PTPN7/CACNA2D4/PDGFB/HSPA8/MAP3K21/RASGRP4/CACNA2D3/KDR/HSPA1L/TGFA/RASGRF1	3.63437168995713
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	34/1300	137/9376	1.789915777653	FOS/GZMB/NFKB1/JUN/BIRC3/CTSD/CTSK/ATM/CTSW/CTSC/GADD45B/CTSH/PRF1/PARP4/PMAIP1/TNFSF10/LMNA/CTSZ/CYCS/IKBKB/KRAS/APAF1/MCL1/TNFRSF10B/BIRC2/NFKBIA/PIK3CB/MAPK8/MAP3K14/PIK3CD/TNFRSF10A/BBC3/TUBA3E/PARP2	3.73669583266064
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	38/1300	160/9376	1.71292307692308	HLA-A/CADM1/PTPRC/HLA-DPA1/SIGLEC1/HLA-DQA1/NCAM1/ICAM1/CD58/SELPLG/NFASC/CD86/HLA-DMA/HLA-DMB/F11R/HLA-DRB1/HLA-DRA/HLA-E/HLA-DPB1/ITGA6/PECAM1/CD22/ITGA4/NECTIN2/ALCAM/NRXN1/HLA-C/PTPRM/SDC1/CLDN4/SPN/ICOSLG/CLDN20/HLA-DQB2/CD40/JAML/CLDN1/CLDN10	3.64914054478488
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	30/1300	119/9376	1.81822882999354	MMP9/FOS/JUNB/NFKB1/JUN/BIRC3/CREB1/ICAM1/TNFAIP3/BCL3/IKBKB/CCL2/CXCL10/MLKL/CXCL3/BIRC2/NFKBIA/PIK3CB/MAPK8/CCL5/MAP3K14/MAP2K6/BAG4/CXCL2/PIK3CD/IL1B/PTGS2/NOD2/LIF/RIPK3	3.60389629809295
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	26/1300	99/9376	1.89414141414141	HLA-DPA1/HLA-DQA1/C1QB/C3/ICAM1/CFH/SELPLG/HLA-DMA/KRT23/HLA-DMB/C1QA/HLA-DRB1/HLA-DRA/HLA-DPB1/IL10/C1QC/FCGR2A/FCGR2B/C3AR1/FPR3/FPR1/C2/C5AR1/CAMP/HLA-DQB2/C5	3.58822104382679
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	11/1300	28/9376	2.83340659340659	ATP6V1F/ATP6V0C/ATP6V1A/TCIRG1/ATP6V0D2/ATP6V1C1/ATP6V0E1/ATP6V1G1/ATP6V0A1/ATP6V1B2/CA2	3.89796209764023
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	23/1300	87/9376	1.90670203359859	FOS/JUN/RAC2/GADD45B/TGFBR1/PMAIP1/BRAF/APPL1/RALGDS/RHOA/CYCS/APC/KRAS/PIK3CB/MAPK8/TGFB2/CTNNB1/PIK3CD/DDB2/RPS6KB2/LEF1/TGFA/BBC3	3.40877937812535
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	66/1300	333/9376	1.42946638946639	ISG15/MX1/HLA-A/CCND3/EIF2AK2/MAML3/MX2/NFKB1/CREB1/STAT1/ATP6V1F/ATP6V0C/PTGER4/WNT4/ATM/IRF9/ITGA1/PPP2R5E/ATP6AP1/STAT2/ATP6V1A/WNT6/HLA-E/DLG1/RB1/TCIRG1/PPP2R5C/ATP6V0D2/ITGA6/EIF4EBP1/ITGA4/ATP6V0B/TLR3/CDKN1B/IKBKB/APC/KRAS/ATR/VTN/FZD1/UBE3A/GNAS/ITGA2/ATP6V1C1/PPP2R2A/HLA-C/PATJ/PIK3CB/ATP6V0E1/CTNNB1/OASL/PPP2R2B/PIK3CD/CDK6/WNT2B/TICAM1/ATP6V1G1/FZD7/ITGB3/ATP6V0A1/PTGS2/ATP6V1B2/RPS6KB2/ITGA3/HES6/HES4	3.20150505333239
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	21/1300	77/9376	1.96699300699301	NFKB1/STAT1/RAC2/GADD45B/TGFBR1/ARHGEF6/RB1/BRAF/RALGDS/IKBKB/KRAS/PLD1/PIK3CB/MAPK8/CDKN2A/TGFB2/PIK3CD/CDK6/DDB2/RPS6KB2/TGFA	3.41829650800712
Organismal Systems	Immune system	hsa04611	Platelet activation	30/1300	126/9376	1.71721611721612	TBXAS1/GNA13/VAMP8/PLA2G4A/PLA2G4C/RASGRP2/LYN/PLCG2/LCP2/SNAP23/PTGS1/GNAQ/RHOA/FERMT3/PPP1CB/PPP1CC/FCGR2A/RAP1A/GNAS/ITGA2/GP6/TLN2/PIK3CB/ADCY7/FCER1G/ORAI1/PLCB2/PIK3CD/ITGB3/P2RY12	3.25179834607768
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	16/1300	54/9376	2.13698005698006	HLA-A/GZMB/HLA-DPA1/HLA-DQA1/CD86/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/PRF1/HLA-E/HLA-DPB1/IL10/HLA-C/HLA-DQB2/CD40	3.36166425999968
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	19/1300	69/9376	1.9859977703456	INPP5D/PLA2G4A/PLA2G4C/LYN/VAV3/RAC2/PLCG2/ALOX5AP/LCP2/ALOX5/KRAS/LAT/VAV1/PIK3CB/MAPK8/GAB2/MAP2K6/FCER1G/PIK3CD	3.2980313568777
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/1300	70/9376	1.95762637362637	HLA-A/HLA-DPA1/HLA-DQA1/ICAM1/CD86/RAC2/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/PRF1/HLA-E/HLA-DPB1/CYCS/HLA-C/EIF4G3/HLA-DQB2/CD40/SGCE	3.22643376102107
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	59/1300	298/9376	1.4279401135777	PRL/IL1RL1/CXCR4/TNFSF13B/IL1RAP/TNFSF12/TNFRSF18/XCL2/CCL8/CCL4/TGFBR1/XCL1/IL13RA1/CCL3/IL2RB/TNFSF10/EDA/CXCL16/IL10/IL18/OSM/TNFRSF14/CCL2/CXCL10/CSF2RA/IL1R2/CXCL3/IFNGR1/TNFRSF10B/IL10RA/TNFSF8/ACVR2A/TGFB2/CCL5/LEPR/TNFSF9/TNFSF13/TNFRSF21/CXCL2/IL7/IL21R/IL1A/IL20RB/CCL23/TNFSF18/IL1B/CXCR3/TNFRSF6B/TNFRSF4/TNFRSF10A/CD40/TNFRSF11A/CCL21/IL12RB1/LIF/LTB/IL27RA/IFNLR1/IFNG	3.01200160990508
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	35/1300	157/9376	1.6078392944635	HLA-A/CCND3/NFKB1/ZFP36L1/IGFBP3/ATM/SQSTM1/ZFP36L2/GADD45B/TGFBR1/PPP3CA/SERPINE1/HLA-E/RB1/CDK1/EIF4EBP1/BTRC/PPP1CB/KRAS/ATR/PPP1CC/HIPK3/NFATC3/SLC25A5/KIR2DL4/HLA-C/PIK3CB/CDKN2A/TGFB2/MAP2K6/PIK3CD/CDK6/IL1A/CALM2/SLC25A4	3.08145514296681
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	36/1300	163/9376	1.59290231241151	MMP9/FOS/IRF7/STAT4/IFIH1/NFKB1/JUN/CREB1/TLR2/STAT1/EGR2/YWHAZ/ATP6AP1/TGFBR1/STAT2/JAK2/RB1/BRAF/CYCS/TLR3/IKBKB/MAP3K1/KRAS/NFATC3/APAF1/NFKBIA/PIK3CB/MAPK8/TGFB2/MAP2K6/TRAF6/IRAK4/PIK3CD/DDB2/TICAM1/EGR3	3.06362475435002
Human Diseases	Immune disease	hsa05310	Asthma	11/1300	32/9376	2.47923076923077	HLA-DPA1/HLA-DQA1/HLA-DMA/HLA-DMB/HLA-DRB1/HLA-DRA/HLA-DPB1/IL10/FCER1G/HLA-DQB2/CD40	3.36282033879298
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	28/1300	120/9376	1.6828717948718	RIPK2/NFKB1/JUN/ARHGDIB/PLCG2/MATK/IRAK3/NFKBIE/BRAF/RPS6KA2/RHOA/IKBKB/MAP3K1/KRAS/MAP2K5/RAP1A/CAMK2D/SH2B3/NFKBIB/NFKBIA/MAP3K3/PIK3CB/MAPK8/TRAF6/IRAK4/PIK3CD/CALM2/CAMK2G	3.02048918037223
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/1300	20/9376	2.88492307692308	FDFT1/DHCR24/SC5D/MSMO1/SQLE/EBP/TM7SF2/DHCR7	3.38549893857174
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	27/1300	116/9376	1.67872679045093	MMP9/CXCR4/THY1/NCF1/ICAM1/VAV3/RAC2/PLCG2/F11R/ITK/PECAM1/RHOH/ITGA4/RHOA/CYBA/TXK/NCF4/CTNND1/RAP1A/VAV1/PIK3CB/CTNNB1/PIK3CD/CLDN4/CLDN20/CLDN1/CLDN10	2.95105736898312
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	48/1300	238/9376	1.45458306399483	ISG15/FOS/MX1/EIF2AK2/MX2/OAS2/OAS1/C1QB/IFIH1/C3/NFKB1/JUN/TLR2/STAT1/RPL36AL/IRF9/PLCG2/STAT2/C1QA/OAS3/TLR7/ADAR/C1QC/TLR3/IKBKB/RSL24D1/CCL2/FCGR2A/CGAS/CXCL10/C3AR1/RPL22L1/CASP1/NFKBIB/C2/NFKBIA/PIK3CB/MAPK8/C5AR1/TRAF6/FAU/IRAK4/PIK3CD/UBA52/IL1B/RPL35/RPL28/C5	2.84993734606882
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/1300	34/9376	2.33339366515837	PER3/PER1/CREB1/PRKAG2/BHLHE40/DBP/BTRC/RBX1/CRY2/FBXL3/BHLHE41	3.1249068336179
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	28/1300	125/9376	1.61555692307692	SGMS1/NFKB1/GNA13/ASAH1/CTSD/ADORA3/PPP2R5E/RAC2/PPP2R5C/GNAQ/RHOA/KRAS/PLD1/SPTLC2/ORMDL2/PPP2R2A/SGPP1/PIK3CB/MAPK8/GAB2/FCER1G/PPP2R2B/PLCB2/PIK3CD/SGPL1/SPTLC3/SPTSSB/SPHK1	2.77963675283917
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	41/1300	201/9376	1.47116724071948	MMP9/NR4A3/MEF2C/GZMB/BMP2K/NFKB1/BIRC3/SPI1/PBX3/FLI1/IGFBP3/CD86/ATM/FUT8/SUPT3H/GADD45B/ETV6/IL2RB/PML/LYL1/AFF1/CDKN1B/DUSP6/PLAU/IGF1/HHEX/RUNX1/IL1R2/MLF1/CDK14/MITF/BIRC2/KLF3/REL/MAF/DDB2/SPINT1/NFKBIZ/CD40/SLC45A3/LDB1	2.70912621454649
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/1300	55/9376	1.96699300699301	SGMS1/GLA/ASAH1/PSAP/HEXB/HEXA/ACER3/SPTLC2/SGPP1/NEU1/GM2A/SGPL1/SPTLC3/SPHK1/NEU3	2.88557643974854
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	43/1300	214/9376	1.44920201294033	FOS/B2M/HLA-A/BST2/CXCR4/NFKB1/JUN/AP1S2/TLR2/PAK1/GNB4/CD247/ATM/RAC2/PLCG2/PPP3CA/HLA-E/CDK1/GNAQ/BTRC/RBX1/CYCS/IKBKB/KRAS/ATR/CGAS/NFATC3/HLA-C/GNG2/NFKBIA/PIK3CB/MAPK8/MAP2K6/LIMK2/CD3E/TRAF6/IRAK4/PIK3CD/AP1S3/CALM2/CUL4B/RPS6KB2/GNGT2	2.66693601291633
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	5/1300	10/9376	3.60615384615385	SQOR/ETHE1/PAPSS2/MPST/BPNT1	3.30812667968514
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1300	51/9376	1.97984917043741	ATP6V1F/ATP6V0C/ATP6AP1/PLCG2/ATP6V1A/TCIRG1/ATP6V0D2/ATP6V0B/GNAS/ATP6V1C1/ATP6V0E1/ATP6V1G1/ATP6V0A1/ATP6V1B2	2.81500425927499
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	23/1300	100/9376	1.65883076923077	CXCR4/XCL2/CCL8/CCL4/XCL1/CCL3/IL2RB/TNFSF10/IL10/IL18/TNFRSF14/CCL2/CXCL10/CXCL3/TNFRSF10B/IL10RA/CCL5/CXCL2/IL20RB/CCL23/CXCR3/TNFRSF10A/CCL21	2.65737388653472
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	41/1300	205/9376	1.44246153846154	HLA-A/CCND3/EIF2AK2/IRF7/RASA2/C3/NFKB1/JUN/CREB1/SP100/EGR2/YWHAZ/YWHAH/LYN/IRF9/HLA-E/DLG1/RB1/PMAIP1/CDK1/KAT2B/ATP6V0D2/RHOA/CDKN1B/KRAS/SCIN/UBE3A/HDAC8/NFKB2/HLA-C/NFKBIA/PIK3CB/CDKN2A/POLB/PIK3CD/REL/CDK6/GTF2B/HDAC9/EGR3/GTF2E1	2.56982333339512
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	40/1300	200/9376	1.44246153846154	FOS/NCK1/MYO5A/NFKB1/JUN/GNA13/PYCARD/PAK1/HCLS1/TLR5/TNFSF10/MYO1F/IL18/RHOA/CYCS/IKBKB/ARPC3/FCGR2A/WIPF1/LPAR5/SEC24B/TMED10/CASP1/ARPC1B/NFKBIB/TNFRSF10B/MYO1D/NFKBIA/MAPK8/TRAF6/IRAK4/CLDN4/MYO1B/IL1B/CLDN20/TNFRSF10A/CYTH2/TUBA3E/CLDN1/CLDN10	2.53759891338973
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	48/1300	250/9376	1.38476307692308	HSPA1B/HSPA1A/HLA-A/SMAP2/CXCR4/EPS15/RAB11FIP1/RAB31/GRK3/MVB12B/ARAP2/TGFBR1/GIT2/CHMP5/VPS37B/IL2RB/SH3KBP1/HLA-E/VPS36/WASHC1/PML/CAPZA1/WASHC4/RHOA/SNX2/AP2A2/RAB8A/ARRB2/ARPC3/PLD1/WIPF1/WWP1/SH3GL2/CHMP1B/IQSEC2/SNX6/VPS45/ARPC1B/HLA-C/TRAF6/RAB11B/AGAP5/CHMP7/HSPA8/CYTH2/RAB11A/HSPA1L/DNM1	2.47390102443511
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/1300	33/9376	2.18554778554779	STX11/VAMP8/STX7/SNAP23/STX6/SEC22B/STX8/VAMP2/VAMP4/VAMP7	2.73710853177226
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	40/1300	204/9376	1.41417797888386	MMP9/TLR2/PAK1/HCLS1/WNT4/VAV3/LUM/PLCG2/WNT6/PLAUR/BRAF/HIF1A/RHOA/PPP1CB/KRAS/PPP1CC/VTN/PLAU/FZD1/IGF1/VAV1/TIAM1/ESR1/CAMK2D/HGF/ITGA2/PPP1R12B/IQGAP1/PIK3CB/TGFB2/CTNNB1/SDC1/PIK3CD/WNT2B/FZD7/ITGB3/CAMK2G/DROSHA/KDR/RPS6KB2	2.39954679836751
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	21/1300	93/9376	1.62858560794045	NFKB1/BIRC3/FHIT/GADD45B/RB1/ITGA6/CYCS/CDKN1B/IKBKB/APAF1/ITGA2/BIRC2/NFKBIA/PIK3CB/CKS2/TRAF6/PIK3CD/CDK6/DDB2/PTGS2/ITGA3	2.44411080784239
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	32/1300	157/9376	1.4700244977952	C1QB/ATP8A1/ELMO1/CREB1/MERTK/SGK1/PTGER4/VPS8/VPS41/CD47/C1QA/JAK2/ALOX5/PECAM1/IL10/HIF1A/C1QC/GAS6/ATP11A/NFATC3/SIGLEC10/CAMK2D/CASP1/ARG1/GPR132/ITGB3/CAMK2G/PTGS2/SPHK1/P2RY12/ARG2/P2RY6	2.3827998933991
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	22/1300	99/9376	1.60273504273504	IL1RAP/PLA2G4A/PLA2G4C/PRKCH/PTGER4/PLCG2/GNAQ/PPP1CB/PPP1CC/IGF1/CAMK2D/GNAS/PIK3CB/MAPK8/ADCY7/MAP2K6/PLCB2/PIK3CD/TRPV2/CALM2/CAMK2G/IL1B	2.41879699339334
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	22/1300	99/9376	1.60273504273504	FOS/PDGFC/JUN/PLA2G4A/PLA2G4C/SLC44A1/RAC2/LYPLA1/WAS/EIF4EBP1/RALGDS/HIF1A/KRAS/PLD1/DGKZ/PIK3CB/MAPK8/PIK3CD/PDGFD/PDGFB/RPS6KB2/DGKQ	2.41879699339334
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	20/1300	88/9376	1.63916083916084	C1QB/C3/CLU/CFH/C1QA/SERPINE1/PLAUR/SERPING1/CD46/C1QC/VTN/PLAU/C3AR1/C2/F5/C5AR1/CR1L/CD59/SERPINF2/C5	2.41684918259279
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	21/1300	94/9376	1.61126022913257	MMP9/HSP90AA1/FOS/FOSB/NFKB1/JUN/TNFAIP3/JUND/USP25/IKBKB/CCL2/CXCL10/HSP90AB1/CXCL3/NFKBIA/MAPK8/TRAF6/CXCL2/IL1B/PTGS2/IFNG	2.38961779586328
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	45/1300	238/9376	1.36367162249515	PDGFC/RASA2/NFKB1/RALGAPA1/PAK1/PLA2G4A/PLA2G4C/RASA1/GNB4/RASGRP2/RAC2/PLCG2/RGL1/RALGDS/RHOA/IKBKB/KRAS/NF1/PLD1/RAP1A/IGF1/LAT/TIAM1/HGF/RASSF1/GNG2/RASAL3/PIK3CB/EXOC2/MAPK8/GAB2/ZAP70/RALGAPB/PIK3CD/REL/PDGFD/CALM2/PDGFB/RASGRP4/KDR/RASA4/GNGT2/TGFA/RASGRF1/HTR7	2.27998229750628
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	17/1300	72/9376	1.70290598290598	ISG15/IRF7/IFIH1/NFKB1/TANK/AZI2/ADAR/ATG5/RNF125/IKBKB/MAP3K1/CXCL10/NFKBIB/NFKBIA/MAPK8/TRAF6/TBKBP1	2.40208182093052
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	23/1300	106/9376	1.56493468795356	MMP9/HSP90AA1/PDGFC/NFKB1/CREB1/RB1/BRAF/CDKN1B/IKBKB/KRAS/PLAU/IGF1/IL1R2/HSP90AB1/NFKBIA/PIK3CB/CTNNB1/PIK3CD/PDGFD/SPINT1/PDGFB/LEF1/TGFA	2.34676967032739
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	43/1300	227/9376	1.36620806506269	B2M/HLA-A/CXCR4/NFKB1/GNA13/CREB1/PTGER4/GNB4/RAC2/CCL4/PPP3CA/CCL3/HLA-E/RB1/EIF4EBP1/GNAQ/RHOA/CYCS/IKBKB/KRAS/CCL2/CGAS/NFATC3/GNAS/HLA-C/GNG2/IL10RA/NFKBIA/PIK3CB/CDKN2A/ADCY7/CCL5/MAP2K6/CTNNB1/PLCB2/PIK3CD/CDK6/CALM2/ITGB3/IL1B/PTGS2/RPS6KB2/GNGT2	2.24085202421847
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	31/1300	154/9376	1.45182817182817	FOS/MEF2C/JUN/PRKAG2/PLA2G4A/PLA2G4C/CAMK1D/PPP3CA/TRPM2/GNAQ/RHOA/PPP1CB/KRAS/PPP1CC/MAP2K5/NFATC3/CAMK2D/GNAS/KCNJ2/EEF2K/PPP1R12B/RGS2/CD38/ADCY7/PLCB2/CACNB4/CALM2/CAMK2G/CACNA2D4/PTGS2/CACNA2D3	2.26819436263174
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	18/1300	79/9376	1.6433106134372	SLC1A3/ATP6V1F/ATP6V0C/ATP6V1A/TCIRG1/ATP6V0D2/ATP6V0B/AP2A2/ATP6V1C1/SLC1A1/VAMP2/ATP6V0E1/ATP6V1G1/ATP6V0A1/ATP6V1B2/UNC13B/DNM1/SLC1A2	2.30367922563853
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1300	80/9376	1.62276923076923	PDGFC/PLCG2/JAK2/BRAF/EIF4EBP1/GAS6/KRAS/NF1/IGF1/HGF/PIK3CB/PIK3CD/PDGFD/PDGFB/KDR/RPS6KB2/TGFA/NRG2	2.24431205582418
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	40/1300	212/9376	1.36081277213353	SIPA1L1/FYB1/PDGFC/DOCK4/SKAP1/RASGRP2/VAV3/RAC2/LCP2/BRAF/GNAQ/RALGDS/RHOA/CTNND1/KRAS/RAP1A/IGF1/LPAR5/LAT/VAV1/TIAM1/SIPA1L3/GNAS/HGF/PFN1/FPR1/TLN2/PIK3CB/ADCY7/MAP2K6/CTNNB1/PLCB2/PIK3CD/CNR1/PDGFD/CALM2/ITGB3/PDGFB/KDR/RGS14	2.13189814557113
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	24/1300	115/9376	1.50517725752508	FOS/MEF2C/NR4A2/MEF2A/GNA13/CREB1/JUND/SGK1/OXSR1/BRAF/GNAQ/PDE4B/RHOA/ARRB2/PLD1/BGLAP/GNAS/MAFB/PDE4D/ADCY7/PLCB2/GATA3/STK39/EGR1	2.18686980528137
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/1300	32/9376	2.02846153846154	ATG4C/ATG5/ATG3/GABARAP/ATG7/ATG10/ATG2B/ATG4D/ATG9B	2.33806073477182
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	43/1300	232/9376	1.33676392572944	RGCC/CXCR4/PDGFC/SSH2/GNA13/PAK1/ITGAD/VAV3/ITGA1/RAC2/IQGAP2/ARHGEF6/BRAF/ITGA6/ITGA4/RHOA/PIP4K2A/APC/PPP1CB/ARPC3/KRAS/PPP1CC/LPAR5/SCIN/VAV1/TIAM1/ITGA2/ARPC1B/PPP1R12B/DIAPH1/PFN1/IQGAP1/PIK3CB/LIMK2/ARHGEF7/PIK3CD/FGD3/PDGFD/ITGB3/PDGFB/ITGA3/PIP4K2C/C5	2.08382194106623
Human Diseases	Cancer: specific types	hsa05214	Glioma	17/1300	76/9376	1.61327935222672	CAMK1D/GADD45B/PLCG2/RB1/BRAF/KRAS/IGF1/CAMK2D/PIK3CB/CDKN2A/PIK3CD/CDK6/DDB2/CALM2/CAMK2G/PDGFB/TGFA	2.15368817866918
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	46/1300	253/9376	1.31132867132867	C3/RIPK2/NFKB1/JUN/ELMO1/PYCARD/HCLS1/ATM/SQSTM1/CAST/MALT1/PLCG2/TLR5/BTRC/ATG5/IL18/RHOA/RBX1/CYCS/IKBKB/ARPC3/CGAS/FNBP1L/ATG14/U2AF1/CASP1/ARPC1B/NFKBIB/DIAPH1/PFN1/NFKBIA/TLN2/PIK3CB/MAPK8/CCL5/UBE2D3/PLCB2/TRAF6/PIK3CD/GLMN/UBA52/IL1B/U2AF1L4/CYTH2/RPS6KB2/RNF31	2.01404746141549
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/1300	23/9376	2.19505016722408	REN/PRCP/LNPEP/CTSA/ATP6AP2/THOP1/ANPEP	2.30215068767852
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	17/1300	77/9376	1.59232767232767	NFKB1/GADD45B/TGFBR1/RB1/BRAF/CDKN1B/IKBKB/KRAS/RUNX1/NFKBIA/PIK3CB/CDKN2A/TGFB2/GAB2/PIK3CD/CDK6/DDB2	2.09386376041115
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	28/1300	144/9376	1.40239316239316	LY96/C1QB/C3/NFKB1/TRA2B/PRKAG2/C1QA/ADIPOR2/C1QC/IKBKB/ALDH2/C3AR1/CXCL3/C2/NFKBIA/MAPK8/MAP3K14/MAP2K6/CTNNB1/C5AR1/TRAF6/IRAK4/CXCL2/SCD5/TICAM1/IL1B/LEF1/C5	1.9522844709395
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	27/1300	138/9376	1.41110367892977	ATP6V1F/ATP6V0C/UQCR10/ATP6AP1/ATP6V1A/COX8A/TCIRG1/ATP6V0D2/NDUFS7/NDUFB5/NDUFS8/COX6B1/CYCS/ATP6V0B/COX7B/UQCRB/ATP5MC2/ATP5F1C/NDUFA7/NDUFS6/COX5A/ATP6V1C1/ATP5MG/ATP6V0E1/ATP6V1G1/ATP6V0A1/ATP6V1B2	1.9519158323394
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	32/1300	169/9376	1.36564406008193	TANK/VAMP8/CTSD/C9orf72/WDR45B/STX7/VPS41/SQSTM1/UVRAG/ATG4C/DEPTOR/HIF1A/ATG5/DAPK1/RAB8A/KRAS/ATG3/NRBF2/ATG14/GABARAP/ATG7/ATG16L2/PIK3CB/MAPK8/ATG10/TRAF6/PIK3CD/ATG2B/UBA52/RPS6KB2/ATG4D/ATG9B	1.92442930919327
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	27/1300	139/9376	1.40095185390149	MMP9/HSP90AA1/HSPA1B/HSPA1A/FOS/FKBP5/JUN/CREB1/NCOA2/CTSD/KRT23/GNAQ/NCOA1/NCOA3/KRAS/ESR1/GNAS/HSP90AB1/EBAG9/PIK3CB/ADCY7/PLCB2/PIK3CD/CALM2/HSPA8/HSPA1L/TGFA	1.91070356282063
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	27/1300	142/9376	1.37135427952329	BIRC3/UBE2W/UBA6/HERC1/PIAS1/ANAPC16/PML/COP1/BTRC/RBX1/HERC3/MAP3K1/WWP1/UBE3A/UBE4B/CDC27/UBE4A/BIRC2/UBE2E1/UBE2D3/TRAF6/RCHY1/DDB2/UBA52/CUL4B/RHOBTB1/UBA7	1.78894434412114
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	37/1300	205/9376	1.30173358348968	MMP9/REN/TBC1D4/NCF1/NFKB1/CTSD/UQCR10/RAC2/TGFBR1/COX8A/NDUFS7/NDUFB5/NDUFS8/CYBA/COX6B1/NCF4/COX7B/PPP1CB/UQCRB/ATP5MC2/ATP5F1C/PPP1CC/MPC2/SLC25A5/NDUFA7/NDUFS6/CAMK2D/COX5A/PIK3CB/MAPK8/TGFB2/PDK3/PLCB2/PIK3CD/CAMK2G/SLC25A4/PDK2	1.75247323420883
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	28/1300	149/9376	1.35533298915849	PDGFC/GNA13/PLA2G4A/PLA2G4C/PLCG2/LPAR6/RALGDS/RHOA/KRAS/PLD1/LPAR5/AGPAT4/GNAS/DGKZ/PIK3CB/ADCY7/GAB2/FCER1G/PLCB2/PIK3CD/PDGFD/PDGFB/AGPAT5/CYTH2/AGPAT1/SPHK1/DNM1/DGKQ	1.75411298077669
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	13/1300	59/9376	1.58915254237288	DPYD/NUDT2/CMPK2/NT5C3A/RRM2B/CMPK1/ENTPD1/DCK/TK2/CDA/CTPS2/AK9/ENTPD5	1.82127226240325
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/1300	101/9376	1.42817974105103	NFKB1/JUN/ICAM1/STAT1/TGFBR1/PLCG2/JAK2/SERPINE1/CDKN1B/KRAS/CCL2/DIAPH1/PIK3CB/MAPK8/TGFB2/PLCB2/PIK3CD/IL1A/IL1B/EGR1	1.73575730687884
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/1300	37/9376	1.75434511434511	APOA1/ICAM1/IL10/GNAQ/IL18/THOP1/PLCB2/IL1B/IFNG	1.8445053338985
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1300	170/9376	1.31518552036199	NFE2L2/HMOX1/WNT4/GADD45B/TGFBR1/MGST2/PLCG2/WNT6/ARID2/RB1/BRAF/DPF3/PBRM1/APC/KRAS/FZD1/ARID1B/HGF/PIK3CB/CDKN2A/TGFB2/CTNNB1/SMARCB1/PIK3CD/CDK6/WNT2B/DDB2/FZD7/RPS6KB2/LEF1/TGFA	1.66385084801106
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	16/1300	78/9376	1.47944773175542	INPP5D/PLCG2/PIK3C2A/PIP4K2A/PPIP5K2/IPMK/PIK3CB/IMPA1/MTM1/INPP5B/PLCB2/PIK3CD/FIG4/PIP4K2C/PPIP5K1/PLCH2	1.70589759915031
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	11/1300	49/9376	1.61908948194662	B4GALT1/GALNT2/C1GALT1/ST6GAL1/GALNT7/GALNT1/FUT10/EOGT/GALNT6/B3GLCT/GXYLT1	1.74316957202282
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1300	38/9376	1.70817813765182	HEXB/HEXA/NAGK/GALK2/AMDHD2/FPGT/UAP1L1/RENBP/GALE	1.75495723560139
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	17/1300	85/9376	1.44246153846154	AK5/NUDT16/LACC1/CMPK2/NT5C3A/RRM2B/CMPK1/ENTPD1/DCK/HPRT1/TK2/AK3/GMPR/CDA/CTPS2/AK9/ENTPD5	1.64404203379584
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	15/1300	73/9376	1.48198103266596	MX1/BST2/CXCR4/MX2/RANBP2/MDFIC/ELL2/KAT2B/BICD1/SUPT4H1/CPSF6/NELFCD/SERINC5/SMARCB1/MAP1S	1.65858993906485
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1300	73/9376	1.48198103266596	PDGFC/GADD45B/RB1/BRAF/KRAS/IGF1/HGF/MITF/PIK3CB/CDKN2A/PIK3CD/CDK6/DDB2/PDGFD/PDGFB	1.65858993906485
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	14/1300	68/9376	1.48488687782805	NFKB1/SPI1/BRAF/PML/EIF4EBP1/IKBKB/DUSP6/KRAS/RUNX1/PIK3CB/PIK3CD/RPS6KB2/LEF1/PIM2	1.60999993876687
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1300	28/9376	1.80307692307692	AKR1B1/PCBD1/MOCS2/GCH1/QDPR/PCBD2/SPR	1.70740272174268
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	30/1300	168/9376	1.28791208791209	PRL/CCND3/STAT4/STAT1/IRF9/STAT2/IL13RA1/JAK2/IL2RB/PIAS1/IL10/OSM/SOCS6/CISH/CSF2RA/MCL1/IFNGR1/IL10RA/PIK3CB/LEPR/IL7/PIK3CD/IL21R/IL20RB/PDGFB/IL12RB1/LIF/IL27RA/IFNLR1/IFNG	1.51074457629516
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/1300	93/9376	1.39593052109181	JUN/PLA2G4A/PLA2G4C/MAP3K2/GNAQ/MAP3K1/KRAS/PLD1/CAMK2D/GNAS/MAP3K3/MAPK8/ADCY7/MAP2K6/PLCB2/CALM2/CAMK2G/EGR1	1.53948492223011
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	28/1300	157/9376	1.2862714355708	CCND3/BIRC3/YWHAZ/YWHAH/WNT4/TGFBR1/WWC1/WNT6/SERPINE1/DLG1/BTRC/APC/PPP1CB/PPP1CC/FZD1/NKD1/PPP2R2A/RASSF1/BIRC2/PATJ/TGFB2/CTNNB1/PPP2R2B/CRB2/WNT2B/FZD7/LEF1/BBC3	1.45125956064215
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	35/1300	203/9376	1.24350132625995	CCND3/PDGFC/JUN/BIRC3/PAK1/VAV3/ITGA1/RAC2/BRAF/ITGA6/ITGA4/RHOA/PPP1CB/PPP1CC/VTN/RAP1A/IGF1/VAV1/HGF/ITGA2/PARVG/PPP1R12B/DIAPH1/BIRC2/TLN2/PIK3CB/MAPK8/CTNNB1/PIK3CD/PDGFD/ITGB3/PDGFB/KDR/ITGA3/RASGRF1	1.40719023396885
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	32/1300	184/9376	1.2543143812709	SRGAP1/CXCR4/NCK1/SSH2/SEMA3B/SEMA3A/PAK1/RASA1/WNT4/SEMA4D/RAC2/EPHB2/SRGAP3/PLCG2/PPP3CA/SRGAP2/RHOA/SEMA4A/KRAS/PLXNC1/NFATC3/ABLIM3/CAMK2D/PIK3CB/LIMK2/PIK3CD/SEMA6B/SEMA3E/CAMK2G/SEMA4C/PLXNA2/ABLIM2	1.39776442453697
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	24/1300	133/9376	1.30146905725853	KLF2/SGK3/PRKAG2/DEPP1/SGK1/ATM/GADD45B/TGFBR1/NLK/BRAF/TNFSF10/IL10/CDKN1B/IKBKB/KRAS/IGF1/GABARAP/PIK3CB/SETD7/MAPK8/TGFB2/PIK3CD/HOMER3/HOMER2	1.40482182598656
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/1300	78/9376	1.38698224852071	BTG2/HSPD1/NUDT16/PAN3/DHX36/XRN1/CNOT6L/PARN/DCP1A/ZCCHC7/CNOT10/CNOT4/LSM6/PATL1/EXOSC9	1.37690105707294
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	22/1300	122/9376	1.30058007566204	CREB1/PRKAG2/PPP2R5E/PPP2R5C/EIF4EBP1/CAB39/ADIPOR2/RAB8A/IGF1/EEF2K/PPP2R2A/STRADB/PIK3CB/LEPR/PPP2R2B/PIK3CD/SCD5/RAB11B/PFKFB2/RPS6KB2/CRTC2/PFKFB3	1.34070897424609
NA	NA	hsa04517	IgSF CAM signaling	49/1300	299/9376	1.18195009004374	SRGAP1/CADM1/NCK1/INPP5D/NCAM1/ICAM1/PAK1/IL1RAP/RASA1/NFASC/CASK/CD86/LYN/VAV3/SRGAP3/PLCG2/CD96/F11R/CD2AP/EPB41L3/LCP2/CD84/SRGAP2/ERC1/ITGA4/RHOA/ARPC3/RAP1A/NECTIN2/VAV1/CRTAM/ARPC1B/IQGAP1/DOK1/CD48/PIK3CB/MAPK8/CABLES1/CTNNB1/TRAF6/PIK3CD/CSK/ITGB3/SH2D1B/PLXNA2/LMO7/JAML/KDR/TUBA3E	1.28284994676543
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	18/1300	98/9376	1.32470957613815	INPP5D/PLCG2/PIK3C2A/PIP4K2A/PPIP5K2/IPMK/DGKZ/PIK3CB/IMPA1/MTM1/INPP5B/PLCB2/PIK3CD/CALM2/PIP4P1/DGKQ/PIP4K2C/PPIP5K1	1.2964032459016
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/1300	73/9376	1.3831822971549	FHIT/GADD45B/PLCG2/RB1/BRAF/KRAS/HGF/RASSF1/PIK3CB/CDKN2A/PIK3CD/CDK6/DDB2/TGFA	1.31860438443713
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1300	37/9376	1.55941787941788	GADD45B/BRAF/CCDC6/NCOA4/KRAS/CTNNB1/DDB2/LEF1	1.36787425654671
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/1300	86/9376	1.34182468694097	NCK1/JUN/PAK1/PLCG2/BRAF/EIF4EBP1/CDKN1B/KRAS/CAMK2D/PIK3CB/MAPK8/PIK3CD/CAMK2G/RPS6KB2/TGFA/NRG2	1.27762662175448
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/1300	93/9376	1.3183788254756	RAC2/TGFBR1/WAS/NLK/RHOA/CTNND1/RAP1A/NECTIN2/PDCD10/CCM2/FER/IQGAP1/PTPN1/PTPRM/CTNNB1/LMO7/LEF1	1.23794296035935
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	12/1300	62/9376	1.39593052109181	HSPA1B/HSPA1A/PRKAG2/ATG5/KRAS/IGF1/PIK3CB/ADCY7/PIK3CD/HSPA8/RPS6KB2/HSPA1L	1.25489060727874
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	27/1300	158/9376	1.2324829600779	ATP6V1F/SGK1/RICTOR/WNT4/ATP6V1A/WNT6/BRAF/DEPTOR/EIF4EBP1/CAB39/RPS6KA2/RHOA/IKBKB/KRAS/SLC38A9/FZD1/IGF1/ATP6V1C1/LAMTOR4/STRADB/PIK3CB/PIK3CD/WNT2B/ATP6V1G1/FZD7/ATP6V1B2/RPS6KB2	1.18238926321956
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1300	32/9376	1.57769230769231	BIRC3/PMAIP1/CYCS/APAF1/BIRC2/MAPK8/BBC3	1.31330113075066
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/1300	38/9376	1.51838056680162	PTPRC/CIITA/BLNK/ZAP70/CD3E/ORAI1/CD40/RFX5	1.28461424906473
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/1300	44/9376	1.47524475524476	B4GALT1/MGAT4A/FUT8/B4GALNT3/MAN2A1/HEXB/HEXA/HEXD/MGAT1	1.26769700746775
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1300	69/9376	1.35884057971015	REN/CREB1/PDE3B/PTGER4/KCNMA1/PPP3CA/GNAQ/GNAS/KCNJ2/ORAI1/PLCB2/CALM2/PDE1C	1.20027399614648
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1300	27/9376	1.60273504273504	HACD4/TECR/HACD2/ELOVL1/SCD5/ELOVL5	1.25830204750792
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	37/1300	227/9376	1.17557438156557	FOS/AHR/NCF1/NFKB1/JUN/NFE2L2/HMOX1/UQCR10/MGST2/COX8A/AKR1A1/BRAF/NDUFS7/NDUFB5/HIF1A/NDUFS8/CYBA/COX6B1/COX7B/IKBKB/UQCRB/ATP5MC2/KRAS/ATP5F1C/PLD1/SLC25A5/NDUFA7/NDUFS6/HGF/COX5A/NFKBIA/PTPN1/PIK3CB/MAPK8/MAP3K14/PIK3CD/SLC25A4	1.07435156641011
NA	NA	hsa04518	Integrin signaling	26/1300	154/9376	1.21766233766234	CCND3/PDGFC/C3/ICAM1/ITGAD/ITGA1/RAC2/ARHGEF6/ITGA6/ITGA4/FERMT3/VTN/IGF1/HGF/ITGA2/PARVG/TLN2/PIK3CB/CTNNB1/PIK3CD/PDGFD/ITGB3/PDGFB/LIMS1/KDR/ITGA3	1.0926730957155
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/1300	70/9376	1.33942857142857	JUN/PAK1/BRAF/HIF1A/RBX1/KRAS/RAP1A/HGF/PIK3CB/TGFB2/PIK3CD/PDGFB/TGFA	1.1436023823834
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1300	122/9376	1.24146279949559	ATP1B3/TBC1D4/STAT1/NCOA2/WNT4/PLCG2/THRB/KAT2B/NCOA1/HIF1A/NCOA3/KRAS/SLC16A10/ESR1/PIK3CB/CTNNB1/PLCB2/PIK3CD/ITGB3/PFKFB2/RCAN2	1.07702196001276
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1300	16/9376	1.80307692307692	GLA/HEXB/HEXA/GBGT1	1.28984751866881
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	32/1300	195/9376	1.18355818540434	NCF1/C3/NFKB1/TLR2/SELPLG/RAC2/PLCG2/CLEC7A/TLR7/CYBA/GSDMD/NCF4/FCGR2A/SLC25A5/FPR3/HDAC8/HAT1/CASP1/ATG7/FPR1/PIK3CB/C5AR1/PLCB2/PIK3CD/CLCN5/CLCN3/CAMP/ITGB3/CR1L/HDAC9/SLC25A4/C5	1.03921456988027
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/1300	103/9376	1.26040328603435	NFKB1/TLR2/IL10/GNAQ/GNAS/IL1R2/CXCL3/GNA15/PIK3CB/TGFB2/PLCB2/CXCL2/PIK3CD/SERPINB9/ARG1/IL1B/ARG2/IFNG	1.06613966671591
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/1300	71/9376	1.32056338028169	PRL/FOS/NFKB1/STAT1/JAK2/KRAS/SOCS6/CISH/ESR1/PIK3CB/MAPK8/PIK3CD/TNFRSF11A	1.08778747472991
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/1300	110/9376	1.24576223776224	HSP90AA1/CPEB3/PDE3B/SPDYE2/CDK1/BRAF/ANAPC16/RPS6KA2/KRAS/IGF1/CDC27/HSP90AB1/PIK3CB/MAPK8/ADCY7/PIK3CD/CPEB4/SPDYA/BUB1	1.04021834033606
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	12/1300	65/9376	1.33150295857988	GLA/AKR1B1/AKR1A1/GK/AGPAT4/ALDH2/LCLAT1/DGKZ/MBOAT1/AGPAT5/AGPAT1/DGKQ	1.07598219032651
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1300	34/9376	1.48488687782805	POLR2J/POLR2J3/POLR3GL/POLR2K/POLR3K/POLR3C/POLR3B	1.13636831916144
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	23/1300	138/9376	1.20205128205128	CPEB3/YWHAZ/YWHAH/SPDYE2/PPP2R5E/PPP3CA/CDK1/ANAPC16/PPP2R5C/BTRC/RPS6KA2/RBX1/PPP1CB/PPP1CC/IGF1/CAMK2D/CDC27/ADCY7/CPEB4/CALM2/CAMK2G/SPDYA/BUB1	0.959337307335919
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1300	41/9376	1.40727954971857	ATM/RBBP8/BABAM2/RAD51B/RAD51C/BRCC3/TOPBP1/BRIP1	1.04854368819506
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1300	60/9376	1.32225641025641	PLA2G4A/PLA2G4C/RAC2/PLCG2/PPP3CA/KRAS/PIK3CB/PIK3CD/PTGS2/KDR/SPHK1	1.00466577886741
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1300	35/9376	1.44246153846154	AKR1B1/HSD17B14/GMDS/TIGAR/FPGT/PFKFB2/PFKFB3	1.05213633843729
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/1300	99/9376	1.23847707847708	MMP9/FOS/JUN/RB1/BRAF/NCOA3/CDKN1B/KRAS/IGF1/ESR1/GNAS/PIK3CB/MAPK8/CDKN2A/ADCY7/PIK3CD/RPS6KB2	0.957016930351522
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1300	23/9376	1.56789297658863	GLUL/GLUD1/GLS/ARG1/ARG2	1.093991902966
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1300	23/9376	1.56789297658863	ATP1B3/MDH1/GLUD1/GLS/CA2	1.093991902966
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/1300	67/9376	1.29175660160735	PPP3CA/BRAF/GNAQ/RPS6KA2/PPP1CB/KRAS/PPP1CC/RAP1A/CAMK2D/PLCB2/CALM2/CAMK2G	0.961536416602275
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	22/1300	133/9376	1.19301330248699	FOS/CREB1/GNB4/PPP2R5E/MAOA/PPP3CA/COMT/PPP2R5C/GNAQ/PPP1CB/ARRB2/PPP1CC/CAMK2D/GNAS/PPP2R2A/GNG2/MAPK8/PPP2R2B/PLCB2/CALM2/CAMK2G/GNGT2	0.89942663603759
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1300	42/9376	1.37377289377289	FTH1/HMOX1/NCOA4/ATG5/GPX4/ACSL1/SAT1/ATG7	0.97399720145152
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1300	12/9376	1.80307692307692	NCAM1/CD46/FCGR2B	1.11680211073539
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/1300	101/9376	1.21395277989337	CREB1/WNT4/WNT6/GNAQ/KRAS/FZD1/CAMK2D/GNAS/MITF/ADCY7/CTNNB1/PLCB2/WNT2B/CALM2/FZD7/CAMK2G/LEF1	0.867322914707229
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1300	18/9376	1.60273504273504	TCN2/MMADHC/MMAB/CD320	1.02690515317433
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	24/1300	148/9376	1.16956340956341	FOS/JUN/WNT4/GADD45B/WNT6/RB1/BRAF/NCOA1/NCOA3/APC/KRAS/FZD1/IGF1/ESR1/NFKB2/PIK3CB/CTNNB1/PIK3CD/CDK6/WNT2B/DDB2/FZD7/RPS6KB2/LEF1	0.834196502609463
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	21/1300	128/9376	1.18326923076923	PDE3B/AK5/NUDT2/FHIT/NUDT16/LACC1/PDE7A/PDE4B/RRM2B/ENTPD1/DCK/HPRT1/PAPSS2/PDE4D/ADCY7/AK3/GMPR/AK9/PDE7B/PDE1C/ENTPD5	0.837586734566447
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	25/1300	155/9376	1.16327543424318	AHR/NR4A1/CREB1/NCEH1/WNT4/WNT6/RB1/BRAF/GNAQ/CDKN1B/APC/RAP1A/FZD1/CAMK2D/GNAS/CDKN2A/ADCY7/CTNNB1/ORAI1/PLCB2/CDK6/WNT2B/FZD7/CAMK2G/LEF1	0.822350280254672
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1300	69/9376	1.2543143812709	FOS/FOSB/JUN/CREB1/MAOA/PPP3CA/PPP1CB/PPP1CC/CAMK2D/GNAS/CALM2/CAMK2G	0.850647769357944
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	17/1300	102/9376	1.20205128205128	ATP1B3/CPB1/KCNMA1/GNAQ/RHOA/RAB8A/RAP1A/GNAS/CD38/ADCY7/PLCB2/CPA1/AMY2B/RAB11A/CA2/ATP2B1/BST1	0.823165783412515
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/1300	50/9376	1.29821538461538	SMS/MAOA/ALDH2/SAT1/LAP3/GAMT/CKB/ARG1/ARG2	0.848255140744856
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	19/1300	116/9376	1.18132625994695	SLC1A3/GRK3/PLA2G4A/PLA2G4C/GNB4/PPP3CA/GNAQ/PLD1/GNAS/SLC1A1/GLUL/GNG2/ADCY7/PLCB2/GLS/HOMER3/HOMER2/GNGT2/SLC1A2	0.788394097794615
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	11/1300	63/9376	1.25929181929182	CCNH/POLR2J/POLR2J3/ERCC1/RBX1/POLR2K/MNAT1/POLE4/DDB2/POLE3/CUL4B	0.828463629930522
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	11/1300	63/9376	1.25929181929182	WNT4/GADD45B/WNT6/APC/FZD1/CTNNB1/SUFU/WNT2B/DDB2/FZD7/LEF1	0.828463629930522
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	25/1300	157/9376	1.1484566389025	FOS/NFKB1/JUN/PRKAG2/UQCR10/COX8A/NDUFS7/NDUFB5/NDUFS8/ADIPOR2/COX6B1/CYCS/COX7B/IKBKB/UQCRB/NDUFA7/NDUFS6/COX5A/PIK3CB/MAPK8/LEPR/PIK3CD/IL1A/MLX/IL1B	0.752604311074435
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/1300	70/9376	1.2363956043956	NFKB1/PRKAG2/JAK2/NFKBIE/APPL1/ADIPOR2/IKBKB/ACSL1/NFKBIB/NFKBIA/MAPK8/LEPR	0.79646381927712
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/1300	90/9376	1.20205128205128	NFKB1/CREB1/PRKAG2/APPL1/EIF4EBP1/ATG5/ADIPOR2/KRAS/IGF1/SESN1/PIK3CB/ADCY7/PIK3CD/EHMT2/RPS6KB2	0.772729842316469
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1300	19/9376	1.51838056680162	IDS/HEXB/HEXA/ARSB	0.907436736468739
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1300	38/9376	1.32858299595142	ATP1B3/SGK1/KRAS/IGF1/PIK3CB/NR3C2/PIK3CD	0.814271262528064
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1300	32/9376	1.35230769230769	GLA/B4GALT1/AKR1B1/GAA/GALM/GALE	0.800921328740085
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/1300	105/9376	1.16770695970696	JUN/SQSTM1/CITED2/RHOT1/HIF1A/USP15/OPA1/KRAS/GABARAP/AMFR/MITF/CCZ1/MAPK8/MTX2/UBA52/ARIH1/ATG9B	0.693332573149044
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	14/1300	86/9376	1.17409660107335	ITGA1/DSC2/ITGA6/LMNA/ITGA4/ITGA2/CTNNB1/CACNB4/ITGB3/CACNA2D4/SGCE/CACNA2D3/ITGA3/LEF1	0.650715003292581
Organismal Systems	Digestive system	hsa04970	Salivary secretion	15/1300	93/9376	1.16327543424318	ATP1B3/KCNMA1/GNAQ/GNAS/CD38/VAMP2/CST3/ADCY7/PLCB2/CALM2/CAMP/AMY2B/ATP2B1/BST1/CST2	0.634859036617833
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1300	14/9376	1.54549450549451	B4GALT1/FUT8/B3GNT2	0.81946279220375
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1300	53/9376	1.22473149492017	ATP1B3/GNAQ/AP2A2/ESR1/GNAS/PLCB2/RAB11A/ATP2B1/DNM1	0.658238367085523
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/1300	60/9376	1.20205128205128	GNA13/PLA2G4A/PLA2G4C/LYN/BRAF/GNAQ/KRAS/IGF1/GNAS/PLCB2	0.629914571727815
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/1300	108/9376	1.13527065527066	RANBP2/NUP58/SRRM1/NUP160/KPNA1/NUP98/XPO4/NXT1/CSE1L/IPO11/XPO7/NUP133/NUP93/NUP35/THOC6/NUP205/NUP43	0.567259291524181
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	18/1300	115/9376	1.12888294314381	DUSP1/PLA2G4A/PLA2G4C/GNB4/MAOA/ALOX5/PTGS1/BRAF/GNAQ/KRAS/KCND2/GNAS/GNG2/PLCB2/GABRB2/PTGS2/GNGT2/HTR7	0.557923407236925
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1300	21/9376	1.37377289377289	CSGALNACT1/DSE/CHST11/CHST13	0.68794657617241
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	41/1300	275/9376	1.07528951048951	HSPA1B/HSPA1A/NCF1/C1QB/CREB1/NCAM1/UQCR10/RAC2/PPP3CA/C1QA/COX8A/NDUFS7/NDUFB5/NDUFS8/C1QC/CYBA/COX6B1/CYCS/NCF4/COX7B/UQCRB/ATP5MC2/ATP5F1C/SLC25A5/NDUFA7/APAF1/PSMA1/NDUFS6/COX5A/PIK3CB/MAPK8/CCL5/PIK3CD/IL1A/IL1B/HSPA8/SLC25A4/HSPA1L/EGR1/TUBA3E/C5	0.508411566654162
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	27/1300	178/9376	1.09400172860847	CCND3/JUN/LGR4/WNT4/RAC2/PPP3CA/WNT6/INVS/NLK/BTRC/DAAM1/RHOA/RBX1/CTNNBIP1/APC/FZD1/NFATC3/CAMK2D/NKD1/MAPK8/BAMBI/CTNNB1/PLCB2/WNT2B/FZD7/CAMK2G/LEF1	0.507993666548523
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1300	41/9376	1.23136960600375	MMP9/RB1/BRAF/DAPK1/KRAS/RASSF1/CDKN2A	0.595662463737863
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1300	109/9376	1.12485532815808	TBC1D4/NFKB1/CREB1/PRKAG2/RPS6KA2/IKBKB/PPP1CB/PPP1CC/PPARGC1B/NFKBIA/PTPN1/PIK3CB/MAPK8/PIK3CD/MLX/RPS6KB2/CRTC2	0.526029266035436
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/1300	75/9376	1.15396923076923	BIRC3/ATM/MGST2/PMAIP1/ERCC1/CYCS/APAF1/BIRC2/PIK3CB/CDKN2A/PIK3CD/BBC3	0.537104645620551
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1300	48/9376	1.20205128205128	CHMP1B/CD81/CLDN4/CLDN20/DPP4/CHMP7/CLDN1/CLDN10	0.563050203354445
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1300	28/9376	1.28791208791209	HACD4/TECR/HACD2/ELOVL1/ELOVL5	0.612123033793899
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1300	15/9376	1.44246153846154	ST6GALNAC3/HEXB/HEXA	0.688048719898645
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	24/1300	158/9376	1.09554040895813	CCNH/CCND3/YWHAZ/YWHAH/ATM/PPP2R5E/GADD45B/RB1/CDK1/ANAPC16/PPP2R5C/RBX1/CDKN1B/ATRX/ATR/WAPL/HDAC8/CDC27/ESCO1/CDKN2A/TGFB2/CDK6/ORC4/BUB1	0.485910682304837
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/1300	110/9376	1.11462937062937	NFKB1/HMOX1/PLCG2/SERPINE1/EIF4EBP1/HIF1A/RBX1/CDKN1B/IGF1/CAMK2D/IFNGR1/PIK3CB/PIK3CD/CAMK2G/RPS6KB2/PFKFB3/IFNG	0.485182649521645
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	15/1300	97/9376	1.11530531324346	FOS/PER3/PER1/CREB1/GNB4/GNAQ/NOS1AP/CAMK2D/GNAS/GNG2/ADCY7/PLCB2/CALM2/CAMK2G/GNGT2	0.457977095995151
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	16/1300	104/9376	1.10958579881657	SGMS1/PLA2G4A/PLA2G4C/ETNK1/LYPLA1/GPD2/LPCAT2/PLD1/AGPAT4/LCLAT1/DGKZ/MBOAT1/PLD4/AGPAT5/AGPAT1/DGKQ	0.450861752829755
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1300	91/9376	1.10958579881657	GRK3/PDE3B/GNB4/PDE7A/PDE4B/ARRB2/GNAS/GNG2/PDE4D/ADCY7/GABRB2/PDE7B/GNGT2/PDE1C	0.42144720605975
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1300	36/9376	1.20205128205128	GALNT2/C1GALT1/ST6GALNAC3/GALNT7/GALNT1/GALNT6	0.48730243549113
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1300	36/9376	1.20205128205128	PRIM2/RNASEH2C/RNASEH2B/POLE4/PRIM1/POLE3	0.48730243549113
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	15/1300	98/9376	1.10392464678179	NR4A2/NR4A1/ATP1B3/CREB1/CAMK1D/GNAQ/CAMK2D/GNAS/ADCY7/ORAI1/DAGLB/PLCB2/CALM2/CAMK2G/ATP2B1	0.414919236504961
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	23/1300	154/9376	1.07716283716284	CREM/ATP1B3/CREB1/PPP2R5E/PPP2R5C/GNAQ/PPP1CB/PPP1CC/CAMK2D/GNAS/PPP2R2A/SCN1B/ADCY7/PPP2R2B/PLCB2/CACNB4/CALM2/CAMK2G/CACNA2D4/KCNE1/CACNA2D3/ATP2B1/SCN7A	0.387360335565746
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/1300	30/9376	1.20205128205128	NFKB1/ABCC3/IKBKB/SHMT1/IL1B	0.444701412295745
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1300	37/9376	1.16956340956341	RIMKLB/GLUL/GLUD1/GLS/ASRGL1/ALDH5A1	0.414612101843131
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1300	37/9376	1.16956340956341	GMDS/NAGK/GALK2/FPGT/UAP1L1/GALE	0.414612101843131
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1300	44/9376	1.14741258741259	CCNH/TAF3/MNAT1/GTF2F2/GTF2B/TAF8/GTF2E1	0.393217376654211
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1300	44/9376	1.14741258741259	CREB1/ARHGDIB/DCTN4/GNAS/VAMP2/RAB11B/RAB11A	0.393217376654211
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1300	17/9376	1.27276018099548	GLUL/GLUD1/CA2	0.451595770932304
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	18/1300	122/9376	1.06411097099622	FOS/JUNB/CREB1/STAT1/IGFBP3/PLCG2/JAK2/GNAQ/MAP3K1/KRAS/IGF1/GNAS/PIK3CB/MAPK8/ADCY7/MAP2K6/PLCB2/PIK3CD	0.285960917312767
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/1300	59/9376	1.10018252933507	GADD45B/BRAF/APC/KRAS/PIK3CB/CTNNB1/PIK3CD/DDB2/LEF1	0.309698505450708
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/1300	130/9376	1.05410650887574	MMP9/FOS/NFKB1/JUN/CREB1/GNB4/TGFBR1/ARRB2/KRAS/GNAS/GNA15/GNG2/NFKBIA/PIK3CB/MAPK8/ADCY7/PLCB2/PIK3CD/GNGT2	0.249231771042826
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/1300	110/9376	1.04906293706294	SKIL/TGFBR1/ID3/RHOA/RBX1/SKI/TGIF1/ACVR2A/TGFB2/LEMD3/HAMP/BAMBI/FST/RPS6KB2/SMAD6/IFNG	0.207664804114438
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	51/1300	362/9376	1.01609859753506	PRL/HSP90AA1/NR4A1/CCND3/PDGFC/NFKB1/CREB1/SGK3/TLR2/YWHAZ/SGK1/YWHAH/GNB4/PKN2/ITGA1/PPP2R5E/LPAR6/JAK2/IL2RB/PPP2R5C/ITGA6/EIF4EBP1/ITGA4/OSM/CDKN1B/IKBKB/KRAS/VTN/IGF1/LPAR5/HGF/ITGA2/HSP90AB1/PPP2R2A/MCL1/GNG2/PIK3CB/PPP2R2B/IL7/PIK3CD/CDK6/PDGFD/ITGB3/PKN3/PDGFB/KDR/RPS6KB2/ITGA3/GNGT2/TGFA/CRTC2	0.125326442140422
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	32/1300	226/9376	1.02121170864534	FOS/ATP1B3/NFKB1/JUN/CREB1/PAK1/PDE3B/VAV3/RAC2/BRAF/PDE4B/RHOA/PPP1CB/PPP1CC/PLD1/RAP1A/VAV1/TIAM1/CAMK2D/GNAS/PDE4D/NFKBIA/PIK3CB/MAPK8/ADCY7/ORAI1/PIK3CD/CALM2/CAMK2G/SUCNR1/ATP2B1/HCAR3	0.129502599168826
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/1300	140/9376	1.03032967032967	KLF2/MEF2C/MEF2A/GNA13/PRKAG2/PDE3B/GNB4/TGFBR1/SERPINE1/PLIN1/GNAQ/KRAS/GNG2/ADCY7/PLCB2/CALM2/RPS6KB2/SPHK1/GNGT2/EGR1	0.145060411355101
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	15/1300	105/9376	1.03032967032967	ITGA1/ITGA6/LMNA/ITGA4/IGF1/GNAS/ITGA2/TGFB2/ADCY7/CACNB4/ITGB3/CACNA2D4/SGCE/CACNA2D3/ITGA3	0.125388644628562
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	24/1300	170/9376	1.01820814479638	JUN/PRKAG2/HCLS1/F11R/DLG1/WAS/RHOA/RAB8A/ARPC3/MAP3K1/RAP1A/TIAM1/RUNX1/ARPC1B/PPP2R2A/PATJ/MAPK8/PPP2R2B/CLDN4/CLDN20/YBX3/TUBA3E/CLDN1/CLDN10	0.0961200156827334
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1300	19/9376	1.13878542510121	OGDH/BCKDHB/DLAT	0.242946980054267
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	14/1300	99/9376	1.0199222999223	PRKAG2/ITGA1/ITGA6/LMNA/ITGA4/IGF1/ITGA2/TGFB2/CACNB4/ITGB3/CACNA2D4/SGCE/CACNA2D3/ITGA3	0.0799488925264337
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1300	63/9376	1.03032967032967	TBXAS1/PLA2G4A/PLA2G4C/ALOX5/PTGS1/LTC4S/GPX4/PTGES3/PTGS2	0.0969063692195997
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	20/1300	143/9376	1.00871436256052	HLA-DPA1/HLA-DQA1/C1QB/C3/CD86/HLA-DMA/HLA-DMB/C1QA/HLA-DRB1/HLA-DRA/HLA-DPB1/IL10/C1QC/FCGR2A/C2/TRIM21/HLA-DQB2/CD40/C5/IFNG	0.0421299928033331
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/1300	56/9376	1.03032967032967	B4GALT1/MGAT4A/FUT8/ST6GAL1/MAN2A1/MGAT1/ALG6/DPAGT1	0.0913298840517315
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1300	56/9376	1.03032967032967	DISP1/GRK3/BTRC/ARRB2/SPOPL/CSNK1G2/CSNK1G3/SUFU	0.0913298840517315
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1300	107/9376	1.01107117181884	SIK2/CREB1/PRKAG2/PDE3B/PPP3CA/PPP4R3A/GNAQ/PHKB/CAMK2D/GNAS/PPP4C/PLCB2/CALM2/CAMK2G/CRTC2	0.0462091731865108
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/1300	78/9376	1.01712031558185	ELMO1/HCLS1/CD2AP/RHOG/RHOA/ARPC3/ARPC1B/PIK3CB/CTNNB1/PIK3CD/DNM1	0.0609148887634716
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	16/1300	115/9376	1.00345150501672	FOS/KCNQ5/CREB1/GNB4/JAK2/GNAQ/KRAS/CAMK2D/KCNJ2/GNG2/PIK3CB/ADCY7/PLCB2/PIK3CD/CAMK2G/GNGT2	0.014941274555442
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1300	20/9376	1.08184615384615	CYB5R4/GMDS/UAP1L1	0.147003381922965
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1300	21/9376	1.03032967032967	DPYD/ALDH2/VNN1	0.0558231835624026
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/1300	103/9376	0.980313666915609	PPP2R5E/PPP2R5C/PPP1CB/PPP1CC/SRRM1/RNMT/CPSF6/PPP2R2A/NXT1/PABPN1/PAPOLG/PPP2R2B/ETF1/CSTF1	-0.0805995228135577
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1300	59/9376	0.977940026075619	PDE3B/PTGS1/PLIN1/GNAS/PIK3CB/ADCY7/PIK3CD/PTGS2	-0.0681949337874284
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1300	29/9376	0.994801061007958	PAK1/WWC1/RASSF2/RASSF1	-0.0112495916431644
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/1300	89/9376	0.972445980985307	PDGFC/MAP3K2/CDK1/GNAQ/KRAS/MAP2K5/GNAS/ADCY7/PLCB2/PDGFD/PDGFB/TUBA3E	-0.104785549100447
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1300	52/9376	0.970887573964497	PLA2G4A/PLA2G4C/ALOX5/IGF1/GNAS/ADCY7/PTGS2	-0.084457475671748
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1300	22/9376	0.983496503496503	HNMT/MAOA/ALDH2	-0.0310919372363771
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	20/1300	150/9376	0.961641025641025	WNT4/GADD45B/TGFBR1/WNT6/RB1/BRAF/CDKN1B/APC/KRAS/FZD1/HGF/PIK3CB/TGFB2/CTNNB1/PIK3CD/WNT2B/DDB2/FZD7/RPS6KB2/LEF1	-0.19000500897167
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/1300	83/9376	0.955848007414273	L3MBTL4/SFMBT1/SFMBT2/SUZ12/SCMH1/FOXK2/MTF2/UBE2D3/RING1/RNF2/PHF1	-0.162095345692252
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/1300	30/9376	0.961641025641025	PIGP/PIGS/PIGC/GPLD1	-0.0844255473089383
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1300	38/9376	0.948987854251012	NAMPT/NADK/CD38/NADSYN1/BST1	-0.126414710545264
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1300	76/9376	0.948987854251012	ATP1B3/GNAQ/CAMK2D/GNAS/KCNJ2/ADCY7/PLCB2/CALM2/CAMK2G/CA2	-0.179142269944756
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	22/1300	166/9376	0.955848007414273	MEF2C/MEF2A/ATP1B3/GNA13/CREB1/PDE3B/ADORA3/KCNMA1/PPP3CA/GNAQ/RHOA/PPP1CB/PPP1CC/NFATC3/SLC25A5/KCNMB1/RGS2/ADCY7/PLCB2/CALM2/SLC25A4/ATP2B1	-0.230268056926136
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1300	46/9376	0.940735785953177	FTH1/HMOX1/BLVRA/MMAB/FXN/ALAS1	-0.161655238409469
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/1300	144/9376	0.951623931623932	KLF4/SKIL/WNT4/ID3/WNT6/JAK2/APC/KRAS/FZD1/KAT6A/IGF1/HESX1/PIK3CB/ACVR2A/CTNNB1/PIK3CD/WNT2B/FZD7/LIF	-0.234705397313457
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/1300	144/9376	0.951623931623932	ATXN1/PUM2/GNAQ/CYCS/OPA1/ATXN10/SLC25A5/NRBF2/ATG14/PSMA1/PIK3CB/MAPK8/OMA1/PLCB2/PIK3CD/ATG2B/GTF2B/SLC25A4/DAB1	-0.234705397313457
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1300	15/9376	0.961641025641025	TPK1/AK5	-0.0596500281043331
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1300	31/9376	0.930620347394541	GLUL/MDH1/SHMT1/ACSS1	-0.155232436522895
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/1300	47/9376	0.920720130932897	AKR1A1/ME1/ALDH2/MDH1/ACSS1/DLAT	-0.218601665203931
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1300	63/9376	0.915848595848596	SMYD3/CAMKMT/ALDH2/SETDB2/SETD7/TMLHE/EHMT2/SMYD2	-0.268872261135861
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	11/1300	86/9376	0.922504472271914	ATP1B3/CREB1/KCNMA1/GNAQ/CAMK2D/GNAS/KCNMB1/VAMP2/ADCY7/PLCB2/CAMK2G	-0.289652424400273
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1300	24/9376	0.901538461538462	EXT2/GLCE/HS6ST3	-0.193766702404743
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/1300	48/9376	0.901538461538462	HIBCH/ALDH2/HIBADH/BCKDHB/OXCT1/MCCC2	-0.274379794528054
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1300	48/9376	0.901538461538462	ATP1B3/PIK3CB/PLCB2/PIK3CD/AMY2B/SLC37A4	-0.274379794528054
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1300	49/9376	0.883139717425432	FOSB/NFKB1/JUN/CREB1/MAOA/GNAS	-0.329043368854292
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/1300	57/9376	0.885721997300945	HACD4/ACSL1/TECR/HACD2/ELOVL1/SCD5/ELOVL5	-0.347195887655175
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/1300	65/9376	0.887668639053254	NR4A1/CREB1/NCEH1/GNAQ/GNAS/ADCY7/ORAI1/PLCB2	-0.364601704647268
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	22/1300	174/9376	0.911900972590628	HSP90AA1/HSPA1B/HSPA1A/HSPH1/DNAJB1/NFE2L2/ATF6/NGLY1/PPP1R15A/RBX1/SEC24B/UBE4B/HSP90AB1/FBXO6/AMFR/MAPK8/UBE2D3/SEC23B/EDEM1/SVIP/HSPA8/HSPA1L	-0.470612851623368
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1300	51/9376	0.848506787330317	PLA2G4A/PLA2G4C/AGPS/LPCAT2/PLD1/PLD4	-0.435224166925652
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	17/1300	138/9376	0.888472686733556	FLOT1/PRKAG2/PDE3B/BRAF/EIF4EBP1/IKBKB/PPP1CB/KRAS/PPP1CC/PHKB/PRKAR2B/PTPN1/PIK3CB/MAPK8/PIK3CD/CALM2/RPS6KB2	-0.529530480169308
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1300	27/9376	0.801367521367521	OXCT1/ALDH5A1/ACSM5	-0.414675830744243
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/1300	52/9376	0.832189349112426	APOA1/NPC2/NCEH1/STARD3NL/TSPO/APOC3	-0.486832115863979
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/1300	44/9376	0.81958041958042	PARP4/POLE4/POLB/POLE3/PARP2	-0.481262254159329
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	47/1300	368/9376	0.921137123745819	RANBP2/CHCHD10/TANK/C9orf72/UQCR10/SQSTM1/PPP3CA/NUP58/ATF6/COX8A/NDUFS7/NDUFB5/NDUFS8/COX6B1/CYCS/COX7B/RAB8A/UQCRB/ATP5MC2/ATP5F1C/NUP160/NRBF2/ATG14/NDUFA7/DCTN4/APAF1/PSMA1/NDUFS6/CASP1/COX5A/NUP98/NXT1/PFN1/MAP2K6/SRSF7/ANG/ATG2B/NUP133/NUP93/FIG4/ALS2/NUP35/SLC1A2/TUBA3E/NRG2/NUP205/NUP43	-0.619215034202253
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1300	28/9376	0.772747252747253	B4GALT1/GCNT2/B3GNT2	-0.483156654154879
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/1300	134/9376	0.861171067738232	GNA13/PLA2G4A/PLA2G4C/PRKCH/KCNMA1/BRAF/GNAQ/RHOA/PPP1CB/PPP1CC/GNAS/PPP1R12B/KCNMB1/ADCY7/PLCB2/CALM2	-0.649394430808608
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/1300	54/9376	0.801367521367521	SMS/LACC1/MPST/MDH1/AHCYL2/ENOPH1	-0.587288844861126
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1300	54/9376	0.801367521367521	ERCC1/ATR/RAD51C/FANCB/BRIP1/RMI1	-0.587288844861126
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	29/1300	235/9376	0.8900294599018	CREB1/PRKAG2/UQCR10/COX8A/PLIN1/NDUFS7/NDUFB5/NDUFS8/RPS6KA2/DPF3/COX6B1/COX7B/COA1/UQCRB/ATP5MC2/ACSL1/KRAS/ATP5F1C/NDUFA7/NDUFS6/ARID1B/GNAS/COX5A/ATP5MG/ADCY7/SMARCB1/CNR1/RPS6KB2/SLC25A29	-0.684971645042409
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/1300	87/9376	0.829000884173298	ATP1B3/UQCR10/COX8A/COX6B1/COX7B/UQCRB/COX5A/CACNB4/CACNA2D4/CACNA2D3	-0.642877415190392
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	33/1300	268/9376	0.888082663605052	DUSP1/NFE2L2/UQCR10/MAOA/ATF6/COX8A/LRRK2/NDUFS7/NDUFB5/NDUFS8/COX6B1/CYCS/COX7B/UQCRB/ATP5MC2/ATP5F1C/SLC25A5/NDUFA7/SLC39A4/APAF1/PSMA1/NDUFS6/CAMK2D/GNAS/COX5A/MAPK8/UBA52/SNCA/CALM2/CAMK2G/UBA7/SLC25A4/TUBA3E	-0.74578288202304
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1300	30/9376	0.721230769230769	OGDH/MDH1/DLAT	-0.613552506913622
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/1300	89/9376	0.810371650821089	ITGA1/CD47/ITGA6/ITGA4/VTN/ITGA2/GP6/SDC1/ITGB3/ITGA3	-0.721140196757782
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/1300	89/9376	0.810371650821089	GNB4/GABARAP/SLC12A5/GLUL/GNG2/ADCY7/GLS/GABRB2/TRAK2/GNGT2	-0.721140196757782
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	18/1300	154/9376	0.842997002997003	TPK1/AK5/CMPK2/AKR1A1/CMPK1/ALDH2/NADK/KYNU/MOCS2/AK3/SHMT1/GCH1/MMAB/CTPS2/NADSYN1/ALAS1/AK9/SPR	-0.788160931350502
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1300	31/9376	0.697965260545906	RBKS/DERA/TKT	-0.675782981887222
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1300	31/9376	0.697965260545906	HSD17B14/AKR1A1/ALDH2	-0.675782981887222
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1300	31/9376	0.697965260545906	DPYD/HIBCH/ALDH2	-0.675782981887222
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1300	31/9376	0.697965260545906	SEC11C/IMMP2L/OXA1L	-0.675782981887222
NA	NA	hsa04981	Folate transport and metabolism	3/1300	31/9376	0.697965260545906	ABCC3/SLCO2B1/SHMT1	-0.675782981887222
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1300	41/9376	0.703639774859287	MAOA/GAMT/SHMT1/ALAS1	-0.76298120963374
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1300	32/9376	0.676153846153846	HIBCH/BCKDHB/ACSS1	-0.73621807729165
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/1300	76/9376	0.75919028340081	APOA1/OLR1/PLIN1/GK/ACSL1/ME1/SCD5/APOC3	-0.845665255263023
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/1300	59/9376	0.733455019556714	SMS/MGST2/GPX4/RRM2B/LAP3/ANPEP	-0.823981812263702
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	30/1300	254/9376	0.851847365233192	CXCR4/PDGFC/CYSLTR1/STIM2/CAMK1D/PLCG2/PPP3CA/GNAQ/NFATC3/SLC25A5/PHKB/CAMK2D/GNAS/HGF/GNA15/CD38/ADCY7/ORAI1/PLCB2/PDGFD/CALM2/CAMK2G/PDGFB/SLC25A4/KDR/SPHK1/ATP2B1/TGFA/HTR7/PDE1C	-0.960373931514724
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1300	33/9376	0.655664335664336	OGDH/BCKDHB/DLAT	-0.794977727710181
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/1300	103/9376	0.77024645257655	ATP1B3/COL14A1/CPB1/PRCP/KCNE3/SLC16A10/COL23A1/SLC1A1/CPA1/DPP4/COL27A1	-0.940653914960655
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	47/1300	388/9376	0.873655828707375	EIF2AK2/NFKB1/UQCR10/WNT4/PPP3CA/WNT6/ATF6/COX8A/BRAF/NDUFS7/NDUFB5/GNAQ/NDUFS8/COX6B1/CYCS/COX7B/IKBKB/APC/UQCRB/ATP5MC2/KRAS/ATP5F1C/FZD1/SLC25A5/NRBF2/ATG14/NDUFA7/SLC39A4/APAF1/PSMA1/NDUFS6/COX5A/PIK3CB/MAPK8/CTNNB1/PLCB2/PIK3CD/IL1A/WNT2B/ATG2B/SNCA/CALM2/FZD7/IL1B/PTGS2/SLC25A4/TUBA3E	-1.01976171059048
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	25/1300	217/9376	0.830911024459412	HSP90AA1/FOS/AHR/KLF4/CCND3/NFKB1/JUN/CREB1/MGST2/JAK2/RB1/EIF4EBP1/RPS6KA2/ARRB2/KRAS/KPNA1/ESR1/GNAS/HSP90AB1/PIK3CB/ADCY7/PTGES3/PIK3CD/PAQR8/RPS6KB2	-1.01106782353618
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/1300	233/9376	0.835760977220205	FBN2/ATP1B3/FMNL2/ITGA1/FMNL1/DSC2/ITGA6/CAPZA1/LMNA/NEB/DAAM1/ITGA4/PDLIM5/FMNL3/ITGA2/DIAPH1/NID2/TLN2/TNNI2/FHL3/SDC1/TNNT1/ITGB3/SGCE/ITGA3/COL27A1/SYNE1	-1.01851894651893
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/1300	71/9376	0.711072589382448	HIF1A/KRAS/SCO2/PIK3CB/PIK3CD/GLS/TIGAR	-0.98043518913401
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1300	45/9376	0.641094017094017	ABCC3/ABCB7/ABCA5/ABCB10	-0.968237768596605
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1300	36/9376	0.601025641025641	AKR1B1/CRYL1/AKR1A1	-0.962236788863196
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1300	36/9376	0.601025641025641	GAA/AGL/AMY2B	-0.962236788863196
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1300	26/9376	0.554792899408284	PLA2G4A/PLA2G4C	-0.912015270395641
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1300	26/9376	0.554792899408284	APOA1/TCN2	-0.912015270395641
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/1300	149/9376	0.774475993804853	GNB4/NDUFS7/NDUFB5/GNAQ/NDUFS8/NDUFA7/NDUFS6/GNG2/MAPK8/ADCY7/DAGLB/PLCB2/CNR1/GABRB2/PTGS2/GNGT2	-1.1133066695567
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1300	46/9376	0.627157190635452	PSMB9/PSMA1/PSME4/IFNG	-1.01700485202526
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/1300	65/9376	0.665751479289941	GNAQ/ARRB2/KRAS/PIK3CB/PLCB2/PIK3CD	-1.08489365213416
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1300	37/9376	0.584781704781705	MAOA/COMT/FAH	-1.01528113021224
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1300	47/9376	0.613813420621931	IKBKB/PIK3CB/MAPK8/PIK3CD	-1.0648482436317
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1300	16/9376	0.450769230769231	MAOA	-0.88213709610108
NA	NA	hsa04081	Hormone signaling	24/1300	219/9376	0.790389884088514	PRL/GNA13/GNB4/JAK2/THRB/APPL1/GNAQ/RHOA/ADIPOR2/IGF1/SLC16A10/ESR1/GNAS/GNA15/GNG2/PIK3CB/ADCY7/HAMP/LEPR/PLCB2/PIK3CD/ITGB3/GNGT2/CALCR	-1.25926417341089
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/1300	67/9376	0.645878300803674	AKR1A1/ADPGK/ALDH2/GALM/ACSS1/DLAT	-1.16707182566034
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1300	17/9376	0.424253393665158	ADO	-0.953235665119881
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1300	17/9376	0.424253393665158	PAPSS2	-0.953235665119881
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1300	17/9376	0.424253393665158	PCDH20	-0.953235665119881
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1300	18/9376	0.400683760683761	ACSL1	-1.02108039337187
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1300	30/9376	0.480820512820513	PLA2G4A/PLA2G4C	-1.1426794665183
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	56/1300	480/9376	0.841435897435898	NFKB1/TANK/C9orf72/ATXN1/UQCR10/WNT4/SQSTM1/PPP3CA/WNT6/ATF6/COX8A/LRRK2/BRAF/NDUFS7/NDUFB5/GNAQ/NDUFS8/COX6B1/CYCS/COX7B/RAB8A/APC/UQCRB/ATP5MC2/KRAS/ATP5F1C/FZD1/SLC25A5/NRBF2/ATG14/NDUFA7/DCTN4/APAF1/PSMA1/NDUFS6/CAMK2D/COX5A/MAPK8/MAP2K6/CTNNB1/PLCB2/IL1A/WNT2B/ATG2B/UBA52/SNCA/CALM2/FZD7/CAMK2G/IL1B/FIG4/PTGS2/ALS2/UBA7/SLC25A4/TUBA3E	-1.4308274542911
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/1300	61/9376	0.591172761664565	FTH1/ATP1B3/HMOX1/SLC39A4/ATP2B1	-1.28520518888175
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	34/1300	308/9376	0.796163836163836	SLC1A3/CREB1/POLR2J/UQCR10/POLR2J3/COX8A/NDUFS7/NDUFB5/GNAQ/NDUFS8/POLR2K/COX6B1/CYCS/AP2A2/COX7B/UQCRB/ATP5MC2/ATP5F1C/SLC25A5/NRBF2/ATG14/NDUFA7/DCTN4/APAF1/PSMA1/NDUFS6/COX5A/MAPK8/PLCB2/ATG2B/SLC25A4/SLC1A2/BBC3/TUBA3E	-1.45935180336796
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1300	42/9376	0.515164835164835	MAOA/ALDH2/KYNU	-1.2634091491976
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/1300	62/9376	0.581637717121588	MAML3/ATXN1/KAT2B/DTX3L/DTX2	-1.32598744288791
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/1300	117/9376	0.678080210387903	ARID2/TFPT/DPF3/PBRM1/BAZ2B/ARID1B/EPC2/SMARCB1/YEATS4/POLE3/NFRKB	-1.40578117476438
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/1300	82/9376	0.615684803001876	DPYD/MGST2/RRM2B/CMPK1/HPRT1/TK2/CDA	-1.40233673080639
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/1300	43/9376	0.503184257602862	ACSL1/ALDH2/ECI1	-1.31002053311215
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/1300	83/9376	0.608266913809082	AGPS/ACSL1/PEX1/NUDT19/PEX11A/PECR/PEX11B	-1.43817087987408
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/1300	75/9376	0.576984615384615	ATP1B3/CREB1/GNAQ/GNAS/ADCY7/PLCB2	-1.47564241966254
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1300	23/9376	0.313578595317726	B4GALT1	-1.32232566645902
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/1300	23/9376	0.313578595317726	PDSS2	-1.32232566645902
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/1300	116/9376	0.621750663129974	TKT/ADPGK/ME1/OGDH/HIBCH/MDH1/GLUD1/SHMT1/ACSS1/DLAT	-1.64460208229245
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/1300	39/9376	0.369861932938856	AHCYL2/SHMT1	-1.58206200195148
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1300	26/9376	0.277396449704142	HHEX	-1.48026720920675
Cellular Processes	Cell motility	hsa04814	Motor proteins	18/1300	194/9376	0.669183187946075	MYO5A/DYNLRB1/KIF16B/CAPZA1/MYO1F/DCTN4/HOOK3/MYO1D/TNNI2/MYO1B/TNNT1/MYO18A/KIF18A/KIF26B/KIFC3/TUBA3E/KIF6/KIF11	-1.8680089478092
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/1300	75/9376	0.480820512820513	TKT/GLUL/SHMT1/ARG1/ARG2	-1.81110026387639
NA	NA	hsa04382	Cornified envelope formation	20/1300	217/9376	0.664728819567529	KRT81/PPP2R5E/TCHH/KRT23/PPP2R5C/ITGA6/KRT86/SPTLC2/PPP2R2A/PPP2R2B/S100A11/ELOVL1/CLDN4/S100A10/CLDN20/SPTLC3/PADI2/S100A1/CLDN1/CLDN10	-2.00475460691933
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/1300	66/9376	0.437109557109557	HSD17B11/COMT/CYP3A5/HSD11B1	-1.84111180006122
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/1300	191/9376	0.641933145388643	FOSB/CREB1/GNB4/MAOA/BRAF/PPP1CB/KRAS/PPP1CC/HDAC8/HAT1/GNAS/GNG2/PKIA/CALM2/HDAC9/GNGT2/SLC29A1	-2.00585891855834
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1300	29/9376	0.248700265251989	CALM2	-1.62568078418874
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/1300	43/9376	0.335456171735242	APOA1/AGPAT1	-1.75229161616197
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1300	90/9376	0.480820512820513	ATP1B3/NCEH1/ABCC3/GNAS/ADCY7/CA2	-1.9855626709675
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1300	70/9376	0.412131868131868	MGST2/CYP3A5/HSD11B1/PTGS2	-1.98064468557311
NA	NA	hsa04082	Neuroactive ligand signaling	16/1300	199/9376	0.579884035562428	SLC1A3/GNB4/ADORA3/P2RY13/GNAQ/GNAS/SLC1A1/GNG2/ADCY7/PLCB2/GABRB2/GNGT2/SLC1A2/HTR7/P2RY12/P2RY6	-2.4032807988207
NA	NA	hsa04519	Cadherin signaling	39/1300	404/9376	0.696237623762376	TAOK3/NFKB1/YWHAZ/YWHAH/KRT81/WNT4/VAV3/RAC2/RERE/KRT23/WWC1/WNT6/DSC2/MYO1F/DAAM1/RHOA/CTNND1/IKBKB/APC/PPP1CB/ARPC3/KRAS/PPP1CC/FZD1/KRT86/VAV1/ARPC1B/SCN1B/MYO1D/NFKBIA/PCDH20/MAPK8/CTNNB1/WNT2B/GABRB2/MYO1B/FZD7/KDR/LEF1	-2.50402805749779
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1300	41/9376	0.175909943714822	GABRB2	-2.12162488300534
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/1300	73/9376	0.296396206533193	MGST2/MAOA/CYP3A5	-2.42123671646782
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	28/1300	323/9376	0.625215527506549	MMP9/NFKB1/HMOX1/FOXP1/ATM/PLCG2/RHOA/MARCKS/CDKN1B/IKBKB/APC/KRAS/PLAU/BMF/MCL1/DICER1/RASSF1/PIK3CB/CDKN2A/TGFB2/PIK3CD/GLS/CDK6/ITGB3/PDGFB/PTGS2/ZEB2/SLC45A3	-2.75008267275284
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/1300	79/9376	0.273885102239533	MGST2/CYP3A5/HSD11B1	-2.60019929790997
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1300	86/9376	0.251592128801431	PLCB2/PDE1C/PKD2L1	-2.79729889824789
Genetic Information Processing	Translation	hsa03010	Ribosome	15/1300	222/9376	0.487318087318087	RPL36AL/MRPS6/MRPL33/RSL24D1/MRPL52/RPL22L1/MRPL54/MRPS18A/MRPL1/FAU/UBA52/MRPL48/MRPL2/RPL35/RPL28	-3.10154572559819
Genetic Information Processing	Transcription	hsa03040	Spliceosome	17/1300	243/9376	0.504564735675847	HSPA1B/HSPA1A/TRA2B/BCAS2/HNRNPU/RP9/PRPF38B/U2AF1/DDX46/LSM6/SRSF7/YJU2/U2AF1L4/HSPA8/THOC6/HSPA1L/BUD13	-3.13936984925225
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	28/1300	370/9376	0.545796257796258	PRL/C3/PTGER4/CYSLTR1/ADORA3/P2RY13/LPAR6/THRB/TSPO/NR3C1/C3AR1/FPR3/UTS2/FPR1/LEPR/C5AR1/P2RY8/CNR1/GABRB2/GALR1/TMEM97/GAL/CALCR/NMUR1/HTR7/LYPD6/C5/P2RY6	-3.57638906232134
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/1300	68/9376	0.10606334841629	CYP3A5	-2.96819324284046
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	9/1300	183/9376	0.354703656998739	XRN1/NXT1/RRP7A/GNL2/RIOK1/RPP38/EFL1/WDR36/DROSHA	-3.53683889511323
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/1300	449/9376	0.128504368682542	GRK3/NCALD/ARRB2/CAMK2D/RGS2/CALM2/CAMK2G/PDE1C	-7.59267440860267