category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	34/440	138/9376	5.25006587615283	NDUFB4/COX6B1/UQCR10/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/NDUFB8/NDUFA7/UQCRH/COX7A2/COX7C/COX17/ATP5F1E/NDUFB2/ATP6V1G1/ATP5PF/COX5B/NDUFA1/ATP5MG/COX5A/ATP5F1C/ATP5ME/NDUFC1/ATP5MC2/NDUFAB1/NDUFA3/NDUFA4/NDUFA2/NDUFB7/PPA1/NDUFS5	11.1605763364605
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	42/440	227/9376	3.9426511814177	NDUFB4/COX6B1/UQCR10/COX8A/UQCR11/COX7B/MGST1/NDUFA6/GSTO1/UQCRQ/COX6A1/NDUFB8/NDUFA7/MGST3/UQCRH/COX7A2/COX7C/ATP5F1E/NDUFB2/SOD2/ATP5PF/COX5B/NDUFA1/VDAC2/COX5A/ATP5F1C/NDUFC1/ATP5MC2/VEGFA/NDUFAB1/NDUFA3/NDUFA4/PRKD1/AKR1C3/MGST2/MAPK13/CBR1/CAT/NDUFA2/GSTO2/NDUFB7/NDUFS5	9.95876067163853
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	39/440	205/9376	4.05392461197339	NDUFB4/MMP9/COX6B1/UQCR10/TGFB2/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/MPC2/NDUFB8/NDUFA7/UQCRH/COX7A2/PDK4/COX7C/ATP5F1E/NDUFB2/ATP5PF/COX5B/NDUFA1/VDAC2/COX5A/PPP1CA/ATP5F1C/MPC1/GAPDH/NDUFC1/ATP5MC2/NDUFAB1/NDUFA3/SMAD3/NDUFA4/MAPK13/NDUFA2/NDUFB7/NDUFS5	9.80996125737655
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	41/440	235/9376	3.71775628626692	NDUFB4/COX6B1/UQCR10/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/NDUFB8/COX20/NDUFA7/UQCRH/COX7A2/COX7C/COX17/COA3/ATP5F1E/NDUFB2/ATP5PF/COX5B/NDUFA1/NDUFAF3/ATP5MG/COX5A/PPARGC1A/ATP5F1C/ATP5ME/NDUFC1/ATP5MC2/RHEB/NDUFAB1/NDUFA3/COX14/NDUFA4/ACSL5/MAPK13/FGFR1/NDUFA2/NDUFB7/NDUFS5	9.36241703029502
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	37/440	268/9376	2.94192672998643	NDUFB4/COX6B1/CALM2/UQCR10/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/NDUFB8/NDUFA7/UQCRH/COX7A2/TUBA4A/COX7C/ATP5F1E/NDUFB2/ATP5PF/COX5B/NDUFA1/VDAC2/COX5A/ATP5F1C/NDUFC1/ATP5MC2/MAOA/SLC18A2/NDUFAB1/NDUFA3/NDUFA4/UBA52/SEM1/SLC39A4/NDUFA2/NDUFB7/NDUFS5	7.15696876987789
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	27/440	157/9376	3.66462072958888	NDUFB4/COX6B1/UQCR10/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/NDUFB8/NDUFA7/UQCRH/COX7A2/LEPR/COX7C/NDUFB2/COX5B/NDUFA1/COX5A/NDUFC1/NDUFAB1/NDUFA3/NDUFA4/MAPK13/NDUFA2/NDUFB7/NDUFS5	7.4710856847993
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	40/440	308/9376	2.76741440377804	GPX3/NDUFB4/COX6B1/HAP1/POLR2J/UQCR10/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/NDUFB8/NDUFA7/UQCRH/COX7A2/TUBA4A/COX7C/ATP5F1E/NDUFB2/SOD2/ATP5PF/COX5B/POLR2I/NDUFA1/VDAC2/COX5A/PPARGC1A/ATP5F1C/NDUFC1/ATP5MC2/NDUFAB1/NDUFA3/NDUFA4/SEM1/POLR2K/ATG2A/NDUFA2/NDUFB7/NDUFS5	6.99839399846363
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	35/440	275/9376	2.71206611570248	NDUFB4/COX6B1/UQCR10/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/NDUFB8/NDUFA7/UQCRH/COX7A2/TUBA4A/COX7C/ATP5F1E/NDUFB2/ATP5PF/COX5B/NDUFA1/VDAC2/COX5A/ATP5F1C/NDUFC1/ATP5MC2/HSPA1B/NDUFAB1/NDUFA3/NDUFA4/SEM1/MAPK13/C5/NDUFA2/NDUFB7/NDUFS5	6.39414849832601
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	39/440	368/9376	2.25830039525692	GPX3/NDUFB4/CHCHD10/COX6B1/HAP1/UQCR10/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/NDUFB8/NDUFA7/UQCRH/COX7A2/ANG/TUBA4A/COX7C/ATP5F1E/NDUFB2/ATP5PF/COX5B/NDUFA1/COX5A/ATP5F1C/NDUFC1/ATP5MC2/NDUFAB1/NDUFA3/NDUFA4/SEM1/MAPK13/CAT/ATG2A/NDUFA2/NDUFB7/PFN1/NDUFS5	5.46429893193866
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	38/440	388/9376	2.08697282099344	NDUFB4/COX6B1/CALM2/UQCR10/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/NDUFB8/NDUFA7/UQCRH/COX7A2/TUBA4A/COX7C/ATP5F1E/NDUFB2/ATP5PF/COX5B/NDUFA1/VDAC2/COX5A/ATP5F1C/GAPDH/NDUFC1/ATP5MC2/NDUFAB1/NDUFA3/NDUFA4/SEM1/BACE2/APH1A/ATG2A/SLC39A4/NDUFA2/NDUFB7/NDUFS5	4.85225272163679
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/440	61/9376	4.1919523099851	FTH1/MT1M/MT2A/FXYD2/MT1F/MT1G/SLC40A1/MT1H/SLC34A2/MT1E/MT1X/SLC39A4	5.54970985528549
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/440	87/9376	3.18411703239289	COX6B1/FXYD2/UQCR10/COX8A/UQCR11/COX7B/UQCRQ/COX6A1/UQCRH/COX7A2/COX7C/COX5B/COX5A	4.54141768552163
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/440	31/9376	4.81173020527859	SEC61G/SEC11C/SEC61B/SEC11A/SRP19/SRP9/SRP54	4.71686823090442
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	39/440	480/9376	1.73136363636364	GPX3/NDUFB4/COX6B1/HAP1/CALM2/UQCR10/COX8A/UQCR11/COX7B/NDUFA6/UQCRQ/COX6A1/NDUFB8/NDUFA7/UQCRH/COX7A2/TUBA4A/COX7C/ATP5F1E/NDUFB2/ATP5PF/COX5B/NDUFA1/VDAC2/COX5A/ATP5F1C/NDUFC1/ATP5MC2/NDUFAB1/NDUFA3/NDUFA4/UBA52/SEM1/MAPK13/CAT/ATG2A/NDUFA2/NDUFB7/NDUFS5	3.65003468340759
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/440	10/9376	8.52363636363636	TST/MPST/SQOR/ETHE1	5.28191145503856
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/440	149/9376	2.2882245271507	NDUFB4/GABRP/NDUFA6/NDUFB8/NDUFA7/NDUFB2/NDUFA1/NDUFC1/NDUFAB1/NDUFA3/NDUFA4/MAPK13/NDUFA2/GNG10/NDUFB7/NDUFS5	3.5171819356138
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/440	20/9376	5.32727272727273	CYP24A1/LBR/EBP/SC5D/DHCR24	4.29857546182946
NA	NA	hsa04382	Cornified envelope formation	20/440	217/9376	1.96397151235861	S100A10/S100A1/S100A11/S100A13/PPP2R5A/KRT7/CLDN1/CLDN4/KRT8/KRT23/KRT18/HAL/JUP/LAMB3/SPTLC3/OCLN/S100A14/KRT10/CLDN10/DSG2	3.18794216171899
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/440	59/9376	2.88936825885978	GPX3/MGST1/GSTO1/GPX4/MGST3/IDH1/MGST2/GSTO2	3.230315709551
NA	NA	hsa03272	Virion - Hepatitis viruses	7/440	48/9376	3.10757575757576	CLDN1/CLDN4/CD9/OCLN/CLDN10/VPS4B/SCARB1	3.24825369255427
Genetic Information Processing	Translation	hsa03010	Ribosome	19/440	222/9376	1.82375102375102	RPL36AL/RPLP1/RPL39/MRPL33/MRPL34/MRPS15/MRPS2/MRPL54/MRPL13/MRPL28/UBA52/MRPL46/RPS27L/FAU/MRPL37/MRPL20/MRPS26/MRPL52/RPL41	2.75617885726687
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/440	63/9376	2.70591630591631	POLR2J/GTF2H5/POLR2I/RBX1/POLR2K/RAD23A/RPA3/POLR2M	3.01455762479502
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/440	28/9376	3.80519480519481	PCBD1/MOCOS/AKR1C3/CBR1/AKR1B1	3.29855011089202
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/440	70/9376	2.43532467532468	UGT2B7/MGST1/CYP3A5/GSTO1/MGST3/MGST2/CBR1/GSTO2	2.67459509229617
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/440	34/9376	3.13368983957219	RORC/NR1D1/PER2/RBX1/CRY2	2.7656117557277
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/440	73/9376	2.33524283935243	UGT2B7/MGST1/CYP3A5/GSTO1/MGST3/MAOA/MGST2/GSTO2	2.54126861898642
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/440	105/9376	2.02943722943723	MITF/FIS1/ATG9B/BNIP3/GABARAPL1/TBC1D15/UBA52/FKBP8/GABARAPL2/CITED2	2.35381120423159
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/440	79/9376	2.15788262370541	UGT2B7/MGST1/CYP3A5/GSTO1/MGST3/MGST2/CBR1/GSTO2	2.2932270880031
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/440	142/9376	1.80076824583867	MMP9/CALM2/MGST1/GSTO1/MGST3/SDC4/EDN1/VEGFA/MGST2/SDC1/MAPK13/GSTO2	2.1335188118058
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/440	82/9376	2.07893569844789	CDA/UGT2B7/MGST1/GSTO1/MGST3/MGST2/UPP1/GSTO2	2.17741670876196
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/440	42/9376	2.53679653679654	FTH1/SLC40A1/GPX4/VDAC2/ACSL5	2.21486630628998
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/440	116/9376	1.83699059561129	MMP9/CLDN1/CLDN4/CXCR4/OCLN/F11R/CLDN10/MAPK13/EZR/MYL12A	2.01272516211674
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/440	133/9376	1.76240601503759	TGFB2/DEPP1/GADD45A/SOD2/BNIP3/GABARAPL1/SMAD3/TNFSF10/MAPK13/CAT/GABARAPL2	1.96492534437451
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	15/440	200/9376	1.59818181818182	CLDN1/CLDN4/TUBA4A/TRADD/OCLN/GAPDH/MYO1C/MYO1D/ARPC3/CLDN10/TNFSF10/MAPK13/EZR/ARHGEF12/ARF6	1.89741312423325
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/440	170/9376	1.62951871657754	CLDN1/CLDN4/TUBA4A/OCLN/PARD6B/ARPC3/MAP3K1/F11R/CLDN10/EZR/MARVELD2/MYL12A/RUNX1	1.83796830840138
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/440	32/9376	2.66363636363636	ATG9B/GABARAPL1/ATG2A/GABARAPL2	2.09173842893586
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	9/440	110/9376	1.74347107438017	ID1/TGFB2/GREM2/ID3/TGIF1/RBX1/ID2/SMAD3/SMAD9	1.74042241308311
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/440	34/9376	2.50695187165775	POLR2J/POLR2I/POLR2K/POLR2M	1.95325662346884
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/440	63/9376	2.02943722943723	PLAAT3/GPX4/HPGD/AKR1C3/LTC4S/CBR1	1.81913839412009
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	17/440	250/9376	1.44901818181818	VAMP8/SLC15A4/MITF/ATP6V1G1/VPS41/CD68/DEPTOR/SLC29A1/AP1M2/BLOC1S2/TPCN1/VPS29/MEAK7/CTSH/LAMTOR2/IDS/SNAPIN	1.59673959752094
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/440	22/9376	2.90578512396694	HNMT/HAL/MAOA	1.98576104426445
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/440	201/9376	1.48421528720036	NUPR1/MMP9/PAX8/MITF/LMO2/GADD45A/PROM1/SPINT1/JUP/ELK4/PER2/HPGD/ID2/RUNX1	1.53983393034281
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/440	37/9376	2.3036855036855	MAOA/MIF/HGD/FAHD1	1.76304706940244
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/440	52/9376	2.04895104895105	APOA1/VDAC2/NCEH1/TSPO/SCARB1	1.68304666407967
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/440	85/9376	1.75486631016043	CDA/DCTPP1/ADA2/PNP/UPP1/ENTPD5/ADK	1.55127456709451
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/440	55/9376	1.93719008264463	SPTLC3/PLPP2/UGT8/CERS2/CERK	1.54674304328254
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/440	41/9376	2.07893569844789	SEM1/RBBP8/SSBP1/RPA3	1.53628123660279
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/440	41/9376	2.07893569844789	MMP9/VEGFA/CDH1/HBEGF	1.53628123660279
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/440	73/9376	1.75143212951432	CXCR4/PPIA/MAP1S/BST2/SUPT4H1/VPS4B	1.43014501463944
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/440	160/9376	1.465	CLDN1/CLDN4/HLA-DMA/LRRC4C/SDC4/OCLN/ALCAM/F11R/CLDN10/SDC1/CDH1	1.31638252249463
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/440	75/9376	1.70472727272727	ARG2/IDH1/TALDO1/GAPDH/PYCR2/PFKL	1.35965049389584
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/440	44/9376	1.93719008264463	AQP3/RAB11A/VAMP2/ARHGDIA	1.3826334317514
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/440	78/9376	1.63916083916084	DCPS/LSM3/LSM5/LSM4/BTG2/PFKL	1.25777536722615
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	13/440	204/9376	1.35793226381462	MMP9/TGFB2/GPC3/SDC4/PPP1CA/VEGFA/SDC1/MAPK13/EZR/FGFR1/ARHGEF12/ERBB3/HBEGF	1.14689670305798
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/440	62/9376	1.71847507331378	CRYAB/SOD2/HSPA1B/FOXA2/CAT	1.25944680702623
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	18/440	300/9376	1.27854545454545	TGFB2/DUSP5/MAP4K3/GADD45A/VEGFB/ELK4/TRADD/EPHA2/NR4A1/DUSP4/VEGFA/HSPA1B/MAP3K1/DUSP3/MAPK13/FGFR1/MAPK8IP3/ERBB3	1.08805251198283
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/440	16/9376	2.66363636363636	MAOA/MIF	1.47781771384691
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/440	31/9376	2.06217008797654	MDH2/CAT/HYI	1.31439427083673
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/440	248/9376	1.28885630498534	S100A10/DYNLT3/DYNLRB1/TUBA4A/VPS41/TRADD/DYNLT1/GAPDH/ARPC3/TNFSF10/MAPK13/MYL12A/ARF6/ANXA2/PFN1	1.02296381686138
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/440	65/9376	1.63916083916084	LPIN3/GPAT4/PLPP2/LCLAT1/AKR1B1	1.14738474027704
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	13/440	212/9376	1.30668953687822	ID1/CALM2/VEGFB/EPHA2/PARD6B/RAPGEF5/VEGFA/RGS14/PRKD1/MAPK13/CDH1/FGFR1/PFN1	1.00222387959935
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	15/440	250/9376	1.27854545454545	CAPZA2/CXCR4/RAB11A/WWP1/DNAJC6/RAB11FIP1/PARD6B/CHMP2A/HSPA1B/ARPC3/SMAD3/VPS29/CHMP5/ARF6/VPS4B	0.990526831633497
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/440	33/9376	1.93719008264463	VAMP8/VAMP2/BET1	1.19669059030984
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/440	194/9376	1.31808809746954	DYNLT3/DYNLRB1/CAPZA2/KIF12/TUBA4A/DYNLT1/MYO1C/KIF22/MYO1D/BICDL1/KIFC3/MYL12A	0.993390576091308
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/440	157/9376	1.35726693688477	CD24/ARG2/ATP8A1/DUSP5/VPS41/GULP1/DUSP4/ATP11A/MAPK13/RAB17	1.00170799850519
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/440	104/9376	1.43426573426573	PLAAT3/GPD1L/LPIN3/GPAT4/PLPP2/CHPT1/LCLAT1	0.988156922150424
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/440	51/9376	1.67130124777184	PLAAT3/PLPP2/UGT8/CHPT1	1.06664160260902
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/440	144/9376	1.33181818181818	ID1/LIF/ID3/ID2/SMAD3/DLX5/MAPK13/FGFR1/SMAD9	0.890376981437966
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/440	89/9376	1.43656792645557	HAP1/GABRP/GABARAPL1/GABARAPL2/SLC38A1/GNG10	0.918225824738672
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/440	54/9376	1.57845117845118	TST/MPST/MDH2/LDHA	0.945909173219231
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/440	37/9376	1.72776412776413	PAX8/GADD45A/CDH1	0.984196272063706
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/440	110/9376	1.35603305785124	EDN1/GAPDH/RBX1/VEGFA/LDHA/PFKL/ELOC	0.833452618448427
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/440	21/9376	2.02943722943723	CSGALNACT1/CHPF	1.04791973239919
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/440	21/9376	2.02943722943723	VNN1/PPCS	1.04791973239919
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/440	56/9376	1.52207792207792	KRTCAP2/SRD5A3/DPM3/TMEM258	0.869484374345286
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/440	169/9376	1.26089295320065	VAMP8/VPS41/ATG9B/DEPTOR/BNIP3/GABARAPL1/RHEB/UBA52/ATG2A/GABARAPL2	0.75942873526688
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/440	93/9376	1.37478005865103	LMO7/ARHGAP29/SMAD3/CDH1/FGFR1/MYL12A	0.805961265790262
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/440	75/9376	1.42060606060606	MGST1/GSTO1/MGST3/MGST2/GSTO2	0.811487308878322
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/440	23/9376	1.85296442687747	SSBP1/RPA3	0.908782104413769
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/440	59/9376	1.44468412942989	CDA/DCTPP1/UPP1/ENTPD5	0.760291236157575
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	10/440	174/9376	1.22466039707419	SEC61G/KRTCAP2/CRYAB/SEC61B/SVIP/RBX1/TMEM258/HSPA1B/RAD23A/SSR4	0.663743724838394
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/440	116/9376	1.2858934169279	IDH1/TALDO1/MDH2/GAPDH/PFKL/CAT/ESD	0.687492639644368
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/440	79/9376	1.34867663981588	ATP6V1G1/VAMP2/SLC1A1/SLC18A2/NAPA	0.69056629662586
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/440	42/9376	1.52207792207792	MAOA/KMO/CAT	0.752430638136822
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	9/440	157/9376	1.22154024319629	CALM2/TGFB2/GADD45A/VDAC2/PPP1CA/RHEB/SMAD3/MAPK13/CHEK2	0.621156369899651
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/440	157/9376	1.22154024319629	ID1/TGFB2/WWC1/PPP1CA/PARD6B/ID2/YWHAH/SMAD3/CDH1	0.621156369899651
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/440	99/9376	1.29146005509642	HLA-DMA/KRT23/KRT18/DEFB1/KRT10/C5	0.646894201106453
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	13/440	238/9376	1.16394194041253	RPL36AL/RPLP1/RPL39/FGA/FGB/ISG15/UBA52/RPS27L/FAU/MAPK13/C5/RPL41/HBEGF	0.568451437594126
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/440	43/9376	1.48668076109937	APOA1/PLPP2/SCARB1	0.7097545246634
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/440	101/9376	1.26588658865887	TGFB2/VEGFB/EDN1/VEGFA/SMAD3/MAPK13	0.596129420882463
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/440	44/9376	1.45289256198347	KRTCAP2/B4GALNT3/TMEM258	0.668150899999797
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/440	26/9376	1.63916083916084	HNF1B/FOXA2	0.724154815834947
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/440	26/9376	1.63916083916084	APOA1/SCARB1	0.724154815834947
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/440	83/9376	1.28368017524644	IDH1/SOD2/PMVK/ACSL5/CAT	0.576010580071725
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/440	45/9376	1.42060606060606	ABCA6/DEFB1/ABCG1	0.627564090072025
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/440	27/9376	1.57845117845118	TECR/HACD2	0.667892257184005
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/440	46/9376	1.3897233201581	FTH1/UGT2B7/BLVRA	0.587942539795881
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/440	66/9376	1.29146005509642	UGT2B7/CYP3A5/SRD5A3/AKR1C3	0.527249973195243
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/440	66/9376	1.29146005509642	HLA-DMA/TGFB2/RORC/SMAD3	0.527249973195243
Organismal Systems	Immune system	hsa04611	Platelet activation	7/440	126/9376	1.18383838383838	VAMP8/FGA/FGB/PPP1CA/MAPK13/ARHGEF12/MYL12A	0.460989460119409
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/440	28/9376	1.52207792207792	TECR/HACD2	0.613896826193792
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/440	28/9376	1.52207792207792	B3GNT5/B4GALNT2	0.613896826193792
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/440	168/9376	1.14155844155844	FTH1/TRADD/VDAC2/CHMP2A/PPIA/TNFSF10/CHMP5/VPS4B/RBCK1	0.410816761520445
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/440	170/9376	1.12812834224599	TGFB2/MGST1/GSTO1/MGST3/GADD45A/SMAD3/MGST2/GSTO2/TXNRD2	0.374088690700791
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/440	69/9376	1.23530961791831	CALM2/PPP1CA/MAOA/SLC18A2	0.435311122134295
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/440	30/9376	1.42060606060606	IDH1/MDH2	0.511992573625259
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/440	70/9376	1.21766233766234	LEPR/TRADD/PPARGC1A/ACSL5	0.405593682110783
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/440	70/9376	1.21766233766234	TGFB2/RBX1/VEGFA/ELOC	0.405593682110783
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/440	50/9376	1.27854545454545	ARG2/MAOA/PYCR2	0.438201408128001
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/440	71/9376	1.20051216389245	ATP6V1G1/F11R/MAPK13/HBEGF	0.376315499206738
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/440	71/9376	1.20051216389245	IDH1/LDHA/PFKL/FGFR1	0.376315499206738
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/440	31/9376	1.37478005865103	TALDO1/PFKL	0.463775780819807
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/440	51/9376	1.25347593582888	SEC61G/ATP6V1G1/SEC61B	0.402752086805635
NA	NA	hsa04517	IgSF CAM signaling	15/440	299/9376	1.06901793858316	LRRC4C/FGA/FGB/TUBA4A/LMO7/CABLES1/PARD6B/ARPC3/F11R/MAPK13/CDH1/EZR/FGFR1/MYL12A/ARF6	0.269132909571586
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/440	133/9376	1.12153110047847	PPP2R5A/CALM2/PPP1CA/MAOA/SLC18A2/MAPK13/GNG10	0.31321833084973
NA	NA	hsa04519	Cadherin signaling	20/440	404/9376	1.05490549054905	KRT7/GABRP/KRT8/WWC1/KRT23/KRT18/JUP/PPP1CA/MYO1C/YWHAH/TMC5/PCDH17/MYO1D/ARPC3/KRT10/MAPK13/CDH1/DSG2/APH1A/FGFR1	0.25032384590013
NA	NA	hsa04518	Integrin signaling	8/440	154/9376	1.10696576151122	FGA/FGB/VEGFB/LAMB3/VEGFA/CDH1/FLNB/TNC	0.296983954087991
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/440	72/9376	1.18383838383838	ISG15/TRADD/MAP3K1/MAPK13	0.347462537639688
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/440	32/9376	1.33181818181818	PFKL/AKR1B1	0.417204659323273
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/440	73/9376	1.16762141967621	MITF/GADD45A/CDH1/FGFR1	0.319021410292457
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/440	94/9376	1.13346228239845	MMP9/TRADD/MAPK13/MAPK6/TRAF4	0.288563959708393
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/440	158/9376	1.0789413118527	PPP2R5A/TGFB2/GADD45A/ANAPC16/RBX1/YWHAH/SMAD3/CHEK2	0.222052121716688
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/440	138/9376	1.08089591567852	PPP2R5A/CALM2/PPP1CA/ANAPC16/RBX1/YWHAH/MAPK13	0.212430834849858
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/440	139/9376	1.07311968606933	MMP9/CALM2/KRT23/KRT18/HSPA1B/KRT10/HBEGF	0.192715498544572
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/440	77/9376	1.10696576151122	TGFB2/GADD45A/VEGFA/SMAD3	0.209128114785468
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/440	77/9376	1.10696576151122	TGFB2/GADD45A/SMAD3/RUNX1	0.209128114785468
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/440	56/9376	1.14155844155844	GLI3/EVC/EVC2	0.235755713441881
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/440	35/9376	1.21766233766234	PFKL/AKR1B1	0.286260233798812
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/440	78/9376	1.09277389277389	CALM2/MAPK13/C5/SERPING1	0.182565498233409
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/440	57/9376	1.12153110047847	TECR/HACD2/ACSL5	0.204211689730227
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/440	36/9376	1.18383838383838	UGT2B7/AKR1B1	0.245219160918333
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/440	36/9376	1.18383838383838	SSBP1/RPA3	0.245219160918333
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/440	37/9376	1.15184275184275	NIT2/RIMKLB	0.205345474724973
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	12/440	253/9376	1.01070786920589	TRADD/BNIP3/RBX1/BCL10/CAPNS1/ARPC3/UBA52/MAPK13/MYL12A/ARF6/RBCK1/PFN1	0.0383120046977897
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	11/440	232/9376	1.01034482758621	CXCR4/RGCC/PPP1CA/ARPC3/SPATA13/EZR/C5/FGFR1/ARHGEF12/MYL12A/PFN1	0.0354029569483772
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	11/440	233/9376	1.00600858369099	CAPZA2/TMOD1/SDC4/JUP/FBN2/LBR/PDLIM5/SNTB1/SDC1/DSG2/NID2	0.0206084871442
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/440	125/9376	1.02283636363636	PPP2R5A/TRADD/SPTLC3/ORMDL2/MAPK13/CERS2	0.0570332358253554
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	14/440	298/9376	1.00109823062843	CXCL14/PRL/IL1RL1/TGFB2/CXCR4/CLCF1/LEPR/LIF/CSF2RA/EDA/TNFSF12/IL1RL2/TNFSF10/TNFRSF14	0.00427510701740235
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/440	38/9376	1.12153110047847	PNP/NMRK1	0.16656842927754
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/440	38/9376	1.12153110047847	FXYD2/SCNN1A	0.16656842927754
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/440	105/9376	1.01471861471861	CALM2/CLEC4E/BCL10/MAPK13/ARHGEF12	0.0336541551488116
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/440	17/9376	1.25347593582888	TXNRD2	0.23210626794481
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/440	17/9376	1.25347593582888	CA12	0.23210626794481
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/440	130/9376	0.983496503496504	MMP9/VEGFB/EDN1/VEGFA/MAPK13/GNG10	-0.0420446840720942
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/440	18/9376	1.18383838383838	ACSL5	0.173229288610879
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/440	109/9376	0.977481234361968	HLA-DMA/RORC/SMAD3/MAPK13/RUNX1	-0.052472124085391
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/440	65/9376	0.983496503496504	NCEH1/NR4A1/SCARB1	-0.0296261267730177
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/440	88/9376	0.968595041322314	FGA/FGB/C5/SERPING1	-0.0656778390994931
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/440	19/9376	1.12153110047847	IDS	0.117662023422503
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/440	156/9376	0.956177156177156	CLDN1/CLDN4/TRADD/OCLN/YWHAH/CLDN10/SCARB1	-0.122472276947549
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/440	43/9376	0.991120507399577	ECI1/ACSL5	-0.012949474385692
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/440	89/9376	0.957711950970378	SDC4/LAMB3/SDC1/TNC	-0.0889437275249909
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	5/440	112/9376	0.951298701298701	HLA-DMA/TGFB2/LAMB3/HSPA1B/MAPK13	-0.115051073981979
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	10/440	224/9376	0.951298701298701	HLA-DMA/TGFB2/ETS2/ELK4/VDAC2/ANAPC16/MAP3K1/SMAD3/CHEK2/TSPO	-0.16369934525899
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/440	67/9376	0.954138398914518	GAPDH/LDHA/PFKL	-0.0835940747113214
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/440	90/9376	0.947070707070707	SOD2/PPARGC1A/RHEB/CAT	-0.111954976681269
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/440	90/9376	0.947070707070707	UGT2B7/FXYD2/NCEH1/SCARB1	-0.111954976681269
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/440	158/9376	0.944073647871116	FNIP2/ATP6V1G1/LPIN3/DEPTOR/CASTOR1/RHEB/LAMTOR2	-0.157313893810948
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/440	181/9376	0.941838272225013	CALM2/HLA-DMA/TGFB2/CLEC4E/TRADD/BCL10/MAPK13/ARHGEF12	-0.175323897428111
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/440	68/9376	0.940106951871658	UGT2B7/CYP3A5/DHRS3	-0.10998743690402
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/440	68/9376	0.940106951871658	JUP/PER2/RUNX1	-0.10998743690402
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/440	137/9376	0.933244857332449	TUBA4A/GADD45A/TRADD/NOL3/TNFSF10/CTSH	-0.17465174325114
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/440	184/9376	0.926482213438735	CXCR4/LRRC4C/EPHA2/PARD6B/SEMA3A/SEMA3E/ARHGEF12/MYL12A	-0.223479001923556
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/440	93/9376	0.916520039100684	CALM2/MAP3K1/MAPK13/HBEGF	-0.17952293192094
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/440	46/9376	0.926482213438735	POMP/SEM1	-0.110910053146079
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/440	117/9376	0.910644910644911	CDK2AP2/MBD2/MEAF6/CHRAC1/BCL7A	-0.21580950999784
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/440	47/9376	0.906769825918762	MDH2/LDHA	-0.14217664898548
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/440	95/9376	0.897224880382775	HLA-DMA/TGFB2/ATP6V1G1/VEGFA	-0.223404956189875
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/440	142/9376	0.900384122919334	WWP1/ANAPC16/RBX1/MAP3K1/UBA52/ELOC	-0.265410558935867
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/440	119/9376	0.895339954163484	MMP9/LIF/TRADD/EDN1/MAPK13	-0.254952729489501
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/440	23/9376	0.926482213438735	ARG2	-0.0783287634017428
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/440	23/9376	0.926482213438735	POMT2	-0.0783287634017428
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/440	23/9376	0.926482213438735	PMVK	-0.0783287634017428
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/440	23/9376	0.926482213438735	NLN	-0.0783287634017428
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/440	23/9376	0.926482213438735	FXYD2	-0.0783287634017428
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/440	49/9376	0.869758812615955	MAOA/SLC18A2	-0.202822342810448
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/440	214/9376	0.896176720475786	CALM2/CXCR4/TRADD/AP1M2/RBX1/BST2/MAPK13/GNG10/ELOC	-0.340915606112867
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/440	98/9376	0.869758812615955	CALM2/NR4A1/PRKD1/SCARB1	-0.287590540542452
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/440	122/9376	0.873323397913562	PPP2R5A/LEPR/PPARGC1A/RHEB/PFKL	-0.312501401708898
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/440	24/9376	0.887878787878788	HS6ST3	-0.122034198285078
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/440	238/9376	0.895339954163484	PLAAT3/CALM2/ETS2/VEGFB/EPHA2/RAPGEF5/VEGFA/FGFR1/ARF6/GNG10	-0.362897702471553
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/440	50/9376	0.852363636363636	HLA-DMA/CXCR4	-0.23225818759787
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/440	50/9376	0.852363636363636	TGFB2/SDC1	-0.23225818759787
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/440	75/9376	0.852363636363636	GPX3/FXYD2/PAX8	-0.284839061156713
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/440	100/9376	0.852363636363636	CXCL14/CXCR4/TNFSF10/TNFRSF14	-0.329346737851775
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/440	100/9376	0.852363636363636	CD24/HLA-DMA/CSF2RA/CD9	-0.329346737851775
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/440	52/9376	0.81958041958042	AKR1C3/SCARB1	-0.289484026221703
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/440	26/9376	0.81958041958042	PLAAT3	-0.204411315629558
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/440	78/9376	0.81958041958042	HLA-DMA/TGFB2/MAPK13	-0.355039436262961
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/440	53/9376	0.804116638078902	FXYD2/RAB11A	-0.317320432998796
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/440	103/9376	0.827537511032657	FXYD2/CPB1/COL14A1/SLC1A1	-0.390520222760868
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/440	105/9376	0.811774891774892	GADD45A/TRADD/BCL10/EDA	-0.430377254667744
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/440	28/9376	0.761038961038961	ATP6V1G1	-0.28098760203895
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/440	155/9376	0.824868035190616	SEC61G/HLA-DMA/TUBA4A/ATP6V1G1/SEC61B/SCARB1	-0.487845894518841
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/440	56/9376	0.761038961038961	BNIP3/HSPA1B	-0.397972947461524
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/440	107/9376	0.79660152931181	CALM2/PPARGC1A/LDHA/PFKL	-0.469530195920444
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/440	180/9376	0.828686868686869	HLA-DMA/TRADD/PPP1CA/RHEB/BST2/C5/TNFRSF14	-0.514953270789467
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/440	29/9376	0.734796238244514	WWC1	-0.317382483374173
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/440	29/9376	0.734796238244514	CALM2	-0.317382483374173
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/440	134/9376	0.795115332428765	CALM2/EDN1/PPP1CA/ADM/ARHGEF12	-0.530052970753009
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/440	30/9376	0.71030303030303	PLAAT3	-0.352640418145351
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/440	59/9376	0.722342064714946	GADD45A/CDH1	-0.474721000539137
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/440	31/9376	0.687390029325513	UGT2B7	-0.386842709197116
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/440	86/9376	0.743340380549683	JUP/SNTB1/DSG2	-0.530565871916413
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/440	60/9376	0.71030303030303	VEGFA/MAPK13	-0.499511204210475
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/440	87/9376	0.734796238244514	TGFB2/GADD45A/SMAD3	-0.551436134621275
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/440	138/9376	0.772068511198946	CALM2/FLOT1/PPARGC1A/PPP1CA/RHEB	-0.598542906010186
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/440	138/9376	0.772068511198946	ARHGEF28/ARPC3/MAPK13/ARHGEF12/ARF6	-0.598542906010186
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/440	32/9376	0.665909090909091	LDHA	-0.420062225483021
Human Diseases	Immune disease	hsa05310	Asthma	1/440	32/9376	0.665909090909091	HLA-DMA	-0.420062225483021
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	5/440	140/9376	0.761038961038961	CALM2/PPARGC1A/SMAD3/CDH1/GNG10	-0.632105472008166
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/440	115/9376	0.741185770750988	CYP24A1/SLC34A2/FGFR1/HBEGF	-0.61965295347216
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/440	62/9376	0.687390029325513	APH1A/TLE2	-0.547987876036719
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/440	33/9376	0.645730027548209	IDH1	-0.452364520616829
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/440	191/9376	0.780961446930033	CALM2/HDAC7/PPP1CA/SLC29A1/MAOA/SLC18A2/GNG10	-0.678637824241956
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/440	116/9376	0.734796238244514	SLC1A1/SHANK2/SLC38A1/GNG10	-0.637739882827999
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/440	216/9376	0.789225589225589	APOA1/MMP9/CALM2/SOD2/ABCG1/HSPA1B/TNFSF10/MAPK13	-0.695404375624016
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/440	63/9376	0.676479076479076	GLI3/GADD45A	-0.571700067229778
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/440	217/9376	0.785588604943444	UGT2B7/MGST1/GSTO1/MGST3/VEGFA/KLF5/MGST2/GSTO2	-0.709078139229805
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/440	243/9376	0.789225589225589	SNU13/SNRPF/LSM3/LSM5/LSM4/HSPA1B/TXNL4A/SNRPG/SNRPD2	-0.738677189721806
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/440	144/9376	0.73989898989899	LPIN3/TRADD/PPARGC1A/MAPK13/C5	-0.697936294430065
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/440	93/9376	0.687390029325513	CALM2/FXYD2/VAMP2	-0.672265030776541
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/440	93/9376	0.687390029325513	GADD45A/LAMB3/TRAF4	-0.672265030776541
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/440	120/9376	0.71030303030303	CALM2/MAP3K1/ARHGDIA/MAPK13	-0.70870141330368
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/440	36/9376	0.591919191919192	GCNT3	-0.544332642917618
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/440	67/9376	0.636092265943012	CALM2/PPP1CA	-0.663311563241906
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/440	37/9376	0.575921375921376	APOA1	-0.57350532261376
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/440	150/9376	0.71030303030303	TGFB2/GADD45A/JUP/SMAD3/CDH1	-0.793639460438381
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/440	97/9376	0.65904404873477	CALM2/PER2/GNG10	-0.748986433727959
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/440	69/9376	0.617654808959157	CALM2/EDN1	-0.707319639660539
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/440	227/9376	0.750981177412895	CALM2/CXCR4/TRADD/RHEB/VEGFA/MAPK13/ARHGEF12/GNG10	-0.842749855143694
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/440	98/9376	0.652319109461967	IMPA2/CALM2/ITPKC	-0.767727454382556
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/440	98/9376	0.652319109461967	PLPP2/ARPC3/ARF6	-0.767727454382556
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	7/440	203/9376	0.734796238244514	VEGFB/LAMB3/PPP1CA/VEGFA/MYL12A/FLNB/TNC	-0.847641865423839
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/440	39/9376	0.546386946386946	HLA-DMA	-0.629875279745856
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/440	70/9376	0.608831168831169	HLA-DMA/SNTB1	-0.728907022981909
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/440	178/9376	0.718283963227783	LGR4/CTNNBIP1/RBX1/SMAD3/CACYBP/TLE2	-0.842006152655873
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/440	254/9376	0.755046528274875	CALM2/CXCR4/VEGFB/VDAC2/VEGFA/TPCN1/ITPKC/FGFR1/ERBB3	-0.878204826978125
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/440	99/9376	0.645730027548209	MMP9/MAPK13/HBEGF	-0.786300512876086
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/440	99/9376	0.645730027548209	CALM2/PPP1CA/MAPK13	-0.786300512876086
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/440	99/9376	0.645730027548209	PLPP2/RHEB/CHPT1	-0.786300512876086
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/440	99/9376	0.645730027548209	TGFB2/EDN1/SNTB1	-0.786300512876086
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/440	71/9376	0.600256081946223	PRL/MAPK13	-0.750227962020074
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/440	154/9376	0.69185360094451	PPP2R5A/CALM2/FXYD2/PPP1CA/MAPK13	-0.855549801511762
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/440	128/9376	0.665909090909091	ADA2/PNP/ENTPD5/ADK	-0.844473700657259
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/440	101/9376	0.632943294329433	CALM2/MITF/EDN1	-0.822957270940651
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/440	41/9376	0.519733924611973	MAOA	-0.683844052297914
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/440	41/9376	0.519733924611973	GABRP	-0.683844052297914
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/440	102/9376	0.626737967914438	FXYD2/RAB11A/CPB1	-0.841047942226895
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/440	103/9376	0.620653133274493	PPP2R5A/PPP1CA/DAZAP1	-0.85898460461935
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/440	103/9376	0.620653133274493	ARG2/TGFB2/LAMB3	-0.85898460461935
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/440	75/9376	0.568242424242424	GADD45A/CHEK2	-0.833002246174231
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	13/440	362/9376	0.765243596182823	PRL/PPP2R5A/VEGFB/LAMB3/EPHA2/NR4A1/RHEB/VEGFA/YWHAH/FGFR1/GNG10/ERBB3/TNC	-1.0107723492338
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/440	76/9376	0.560765550239234	APOA1/ACSL5	-0.853104265342222
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/440	76/9376	0.560765550239234	CALM2/EZR	-0.853104265342222
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/440	76/9376	0.560765550239234	CALM2/GADD45A	-0.853104265342222
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/440	187/9376	0.683714146815751	TXNIP/VDAC2/GABARAPL1/MAPK13/GABARAPL2/RBCK1	-0.969408539613031
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/440	44/9376	0.484297520661157	GTF2H5	-0.760814163503418
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/440	44/9376	0.484297520661157	MBD4	-0.760814163503418
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/440	44/9376	0.484297520661157	HLA-DMA	-0.760814163503418
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/440	106/9376	0.603087478559177	MMP9/SPINT1/FGFR1	-0.911902196522278
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/440	45/9376	0.473535353535354	HLA-DMA	-0.785510095450383
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/440	163/9376	0.653653095370887	MMP9/TGFB2/MAP3K1/SMAD3/MAPK13	-0.989794357307383
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/440	78/9376	0.546386946386946	IMPA2/ITPKC	-0.892644370759332
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/440	78/9376	0.546386946386946	ARPC3/CDH1	-0.892644370759332
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/440	80/9376	0.532727272727273	VEGFA/ERBB3	-0.931338950029821
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/440	110/9376	0.581157024793388	ANAPC16/KIF22/MAPK13	-0.980486970820944
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/440	166/9376	0.64184008762322	CALM2/FXYD2/ADRA2A/VDAC2/PPP1CA	-1.03309818947685
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/440	48/9376	0.443939393939394	FXYD2	-0.857015891565361
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/440	195/9376	0.655664335664336	FGA/FGB/VDAC2/HDAC7/MAPK13/C5	-1.07818854928772
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/440	168/9376	0.634199134199134	PRL/CLCF1/LEPR/LIF/CSF2RA	-1.06159071402072
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/440	82/9376	0.519733924611973	HLA-DMA/HSPA1B	-0.969232345083928
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/440	196/9376	0.652319109461967	CALM2/TRADD/VEGFA/UBA52/MAPK13/GNG10	-1.09151048739675
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/440	49/9376	0.434879406307978	POMT2	-0.88005250171029
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/440	83/9376	0.513472070098576	MBD6/L3MBTL4	-0.987891504509113
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/440	115/9376	0.555889328063241	MAOA/SLC18A2/GNG10	-1.06328964343512
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/440	86/9376	0.495560253699789	ERBB3/HBEGF	-1.04277608763802
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/440	86/9376	0.495560253699789	FXYD2/VAMP2	-1.04277608763802
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	6/440	205/9376	0.623680709534368	HLA-DMA/ISG15/GADD45A/TRADD/SEM1/MAPK13	-1.20883064545781
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/440	54/9376	0.394612794612795	RPA3	-0.989956166151442
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/440	54/9376	0.394612794612795	HLA-DMA	-0.989956166151442
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/440	122/9376	0.523994038748137	PPP2R5A/BCL10/MAPK13	-1.17426997300967
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/440	122/9376	0.523994038748137	FXYD2/RHEB/PFKL	-1.17426997300967
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/440	91/9376	0.468331668331668	GABRP/GNG10	-1.1308654381876
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/440	154/9376	0.553482880755608	UGT2B7/DHRS3/PPCS/KMO	-1.23972772004501
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/440	93/9376	0.458260019550342	HLA-DMA/MAPK13	-1.16500712963214
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/440	59/9376	0.361171032357473	PLAAT3	-1.09222711888749
NA	NA	hsa04081	Hormone signaling	6/440	219/9376	0.583810709838107	PRL/SLC40A1/LEPR/ADRA2A/SMAD9/GNG10	-1.38285532694106
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/440	103/9376	0.413768755516328	TGFB2/MAPK13	-1.32744898647783
NA	NA	hsa04082	Neuroactive ligand signaling	5/440	199/9376	0.535404294198264	GABRP/ADRA2A/SLC1A1/SLC18A2/GNG10	-1.4699134374662
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/440	105/9376	0.405887445887446	TGFB2/SNTB1	-1.35844007430086
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/440	69/9376	0.308827404479578	MAPK13	-1.27863502055796
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/440	370/9376	0.633513513513513	PRL/GABRP/SPX/NMB/LEPR/ADRA2A/EDN1/NR3C1/ADM/C5/TSPO	-1.59600134340121
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/440	173/9376	0.492695743562796	HLA-DMA/RAB11A/TRADD/TNFSF10	-1.49440132219819
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/440	142/9376	0.450192061459667	TGFB2/MITF/MAPK13	-1.4648752443067
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/440	109/9376	0.390992493744787	PPARGC1A/PPP1CA	-1.41907944470935
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/440	144/9376	0.443939393939394	VDAC2/SEM1/ATG2A	-1.49209293236408
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/440	73/9376	0.291905354919054	GADD45A	-1.34766399622802
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/440	149/9376	0.429042098840757	PLPP2/RHEB/ARF6	-1.55886087683404
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/440	333/9376	0.575921375921376	PPP2R5A/ISG15/ATP6V1G1/LAMB3/TRADD/PARD6B/RHEB/VEGFA/TNC	-1.74844763461908
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/440	155/9376	0.412434017595308	NCEH1/NR4A1/SCARB1	-1.63671807477889
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/440	122/9376	0.349329359165425	MAP3K1/MAPK13	-1.60515425866005
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/440	83/9376	0.256736035049288	POLR2K	-1.50919219936939
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	5/440	226/9376	0.471440064360418	CALM2/FXYD2/GLI3/EDN1/PPP1CA	-1.7847537775626
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/440	86/9376	0.247780126849894	SCNN1A	-1.55498630335964
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/440	89/9376	0.239427987742594	TUBA4A	-1.59969805592048
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/440	323/9376	0.527779341401632	MMP9/TGFB2/CYP24A1/VEGFA/EZR/ERBB3/TNC/SLC7A1	-1.91641861166678
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/440	90/9376	0.236767676767677	MAPK13	-1.61437367138105
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/440	91/9376	0.234165834165834	BCL10	-1.62893920502558
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/440	205/9376	0.415787139689579	TRADD/HDAC7/HPN/YWHAH	-1.87663621532656
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/440	136/9376	0.313368983957219	TRADD/HSPA1B	-1.7897702388906
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/440	143/9376	0.298029243483789	HLA-DMA/C5	-1.87696432219521
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/440	183/9376	0.349329359165425	NOP10/SNU13/POP7	-1.97241602535376
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/440	148/9376	0.287960687960688	GADD45A/FGFR1	-1.93740953623566
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/440	109/9376	0.195496246872394	MAPK13	-1.87461521825067
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/440	154/9376	0.276741440377804	CALM2/PPP1CA	-2.00808355711151
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/440	193/9376	0.331229392369289	CXCL14/CXCR4/GNG10	-2.08307034570134
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/440	115/9376	0.185296442687747	GNG10	-1.95056302336105
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/440	133/9376	0.160218728639781	TNFSF10	-2.16434218943745
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/440	449/9376	0.0474589997975299	CALM2	-4.58980756660511