category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	88/1827	235/9376	1.92173659877255	CREB5/NDUFB4/ADCY4/NDUFC2/FGFR1/NDUFC1/NDUFS7/NDUFB3/COX7A2/RPS6KA2/KRAS/ATP5F1C/MAP2K3/COX8A/COX14/UQCRFS1/NDUFB9/COX20/NDUFA12/NDUFAF3/CREB1/COX5A/NDUFA8/RPS6KA3/PNPLA2/COX17/NDUFS8/SMARCD1/ACSL5/COX7A1/NDUFS2/COX6B1/COX6A1/PRKAA1/COX5B/UQCR11/NDUFS6/ATP5ME/NRAS/NDUFA7/NDUFAF8/SOS2/UQCRQ/UQCRH/SDHD/NDUFA2/NDUFAB1/MAPK14/ATP5MC1/UQCR10/NDUFA3/NDUFB11/COX7C/COA1/NPR1/MAPK12/ACSL3/ATP5MC2/COX7B/RHEB/NDUFA13/CYC1/COA5/UQCRB/ATP5PF/MTOR/CPT1A/HRAS/NDUFB2/COX10/PRKAG2/PRKAG1/NDUFAF4/ATP5MG/NDUFA4/COX19/ADCY6/SIRT6/MT-ND4/MT-CO2/COA6/UQCRC1/GNAS/SLC25A20/PRKAB2/COA7/PLIN1/RPS6KB2	7.0396992875009
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	59/1827	138/9376	2.19407756439241	NDUFB4/NDUFC2/NDUFC1/NDUFS7/ATP6V1F/NDUFB3/COX7A2/ATP6V1A/ATP5F1C/COX8A/UQCRFS1/NDUFB9/NDUFA12/ATP6V0B/COX5A/NDUFA8/ATP6AP1/COX17/NDUFS8/COX7A1/NDUFS2/COX6B1/COX6A1/COX5B/CYCS/UQCR11/NDUFS6/ATP5ME/NDUFA7/UQCRQ/UQCRH/SDHD/NDUFA2/NDUFAB1/ATP5MC1/UQCR10/NDUFA3/ATP6V0C/ATP6V1E1/NDUFB11/COX7C/ATP6V1G1/ATP5MC2/COX7B/NDUFA13/CYC1/UQCRB/PPA1/ATP5PF/NDUFB2/COX10/ATP5MG/NDUFA4/MT-ND4/MT-CO2/ATP6V0A2/UQCRC1/ATP6V0E1/ATP6V1B2	6.95173649514786
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	82/1827	227/9376	1.85381779427048	MGST2/MGST3/NOX4/NDUFB4/NDUFC2/PRKD3/NDUFC1/NDUFS7/PIK3R3/ABL2/NDUFB3/COX7A2/KRAS/ATP5F1C/SLC25A5/COX8A/AHR/UQCRFS1/NDUFB9/NDUFA12/RAC1/PRKD2/COX5A/NQO1/NDUFA8/AKR1C3/NDUFS8/COX7A1/NDUFS2/COX6B1/COX6A1/COX5B/UQCR11/NDUFS6/MAPK3/NRAS/MAP2K4/NDUFA7/SOS2/UQCRQ/VDAC3/UQCRH/SDHD/NDUFA2/NDUFAB1/PTPN1/MAPK14/ATP5MC1/UQCR10/NDUFA3/RELA/NDUFB11/COX7C/MAPK8/PLD1/MAPK12/ATP5MC2/COX7B/PRKD1/EPHX4/NDUFA13/EPHX1/SLC26A2/CYC1/CHUK/UQCRB/ATP5PF/HRAS/NDUFB2/MET/AKT3/ARAF/NDUFA4/MAP3K14/IKBKG/MT-ND4/MT-CO2/BRAF/UQCRC1/NFKBIA/PTK2/GSTM4	6.40621508275551
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	87/1827	248/9376	1.80030721966206	LY96/RHOJ/TUBB6/S100A10/ARPC5L/LEF1/ARF6/KPNA4/NOD1/KPNA1/NCKAP1/MAP2K3/TNFRSF1A/GSDMD/PODXL/RAC1/RHOG/BIRC2/CYTH2/KLC1/MYL12A/TUBB2A/BAX/ABI1/TNFSF10/ARL8A/DYNLRB1/CYCS/PLEKHM1/MAPK3/MAP2K4/KPNA3/ARPC1A/RIPK2/PFN1/MAPK14/MYO6/DYNLL2/ARPC3/MYD88/IL6/ACTR10/RELA/TNFRSF10B/TRAF6/MYC/BRK1/MAPK8/RALA/MLKL/TUBA1A/DYNC1LI1/PIK3C2A/DCTN6/MAPK12/EXOC2/RHOB/MAP3K7/TNFRSF10A/FHOD1/PIK3C2B/ACTR2/CHUK/PYCARD/CYTH3/HRAS/ARPC1B/CASP1/FBXO22/TUBA4A/AKT3/IRAK1/RILP/TCF7L1/ACTR3/MAP2K6/CYTH1/IKBKG/SNX9/DYNLL1/TIRAP/TLR5/NFKBIA/GAPDH/MYL12B/WASF3/HSP90B1	6.28354831289731
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	75/1827	205/9376	1.87752813488726	REN/NDUFB4/MMP9/NDUFC2/NDUFC1/NDUFS7/PIK3R3/NDUFB3/COX7A2/ATP5F1C/TGFBR1/TBC1D4/SLC25A5/COX8A/CTSD/PPP1CA/UQCRFS1/NDUFB9/PPP1CC/NDUFA12/RAC1/COX5A/NDUFA8/PTPA/SMAD2/SMAD3/NDUFS8/COX7A1/NDUFS2/COX6B1/COX6A1/COX5B/UQCR11/NDUFS6/NDUFA7/UQCRQ/VDAC3/UQCRH/SDHD/NDUFA2/NDUFAB1/MAPK14/ATP5MC1/UQCR10/NDUFA3/RELA/NDUFB11/COX7C/MAPK8/SP1/MAPK12/ATP5MC2/COX7B/PDHB/NDUFA13/CYC1/UQCRB/PPP1CB/ATP5PF/MTOR/NOS3/NDUFB2/RYR2/AKT3/NDUFA4/PRKCZ/ACE/MT-ND4/TGFB2/MT-CO2/TGFB3/UQCRC1/CAMK2G/PDK4/GAPDH	6.24942172033795
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	60/1827	157/9376	1.96123958039179	LEPR/NDUFB4/NDUFC2/MAP3K11/NDUFC1/NDUFS7/PIK3R3/NDUFB3/COX7A2/COX8A/TNFRSF1A/ADIPOR1/UQCRFS1/NDUFB9/NDUFA12/RAC1/COX5A/NDUFA8/EIF2S1/NDUFS8/COX7A1/BAX/NDUFS2/COX6B1/COX6A1/PRKAA1/COX5B/CYCS/UQCR11/NDUFS6/NDUFA7/UQCRQ/UQCRH/SDHD/NDUFA2/NDUFAB1/MAPK14/UQCR10/ADIPOR2/NDUFA3/IL6/RELA/NDUFB11/COX7C/MAPK8/MAPK12/COX7B/SOCS3/NDUFA13/CYC1/UQCRB/NDUFB2/PRKAG2/PRKAG1/AKT3/NDUFA4/MLX/MT-CO2/UQCRC1/PRKAB2	5.97516308166665
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	35/1827	77/9376	2.33268647061751	SHC1/CDKN1A/PIK3R3/KRAS/TGFBR1/SMAD3/BAX/CRK/MAPK3/NRAS/STAT5A/SOS2/CBL/SMAD4/BCL2L1/RELA/HDAC1/MYC/HDAC2/BCR/DDB2/CHUK/SHC2/HRAS/POLK/AKT3/ARAF/IKBKG/CTBP2/GADD45B/TGFB2/BRAF/TGFB3/NFKBIA/MECOM	5.77650863286043
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	94/1827	300/9376	1.60799854041233	JUND/DUSP5/ANGPT2/DUSP6/KDR/NFATC1/EFNA1/HSPA1B/CDC25B/GNG12/HSPA1A/MAX/FGFR1/MAP3K11/MAP3K13/RPS6KA2/RPS6KA5/DUSP3/RASA2/KRAS/TGFBR1/NR4A1/MAP2K3/TNFRSF1A/EPHA2/RAC1/DUSP1/RPS6KA3/ELK4/CRK/MAP3K8/RASGRF2/RASGRP2/MAPK3/STMN1/NRAS/MAP2K4/DUSP8/SOS2/TAOK2/MAP3K3/MAPK14/FLT4/MYD88/ARRB1/RELA/MKNK2/TRAF6/MYC/MAPK8/GNA12/DUSP10/PDGFB/MAP3K1/MAPK12/MAP3K7/NLK/RASGRP3/RAP1A/MAP4K2/CHUK/MRAS/PPP5C/CSF1/HRAS/MEF2C/PDGFA/NF1/MET/MAPK7/PDGFD/RAPGEF2/AKT3/ARAF/KITLG/IRAK1/ELK1/MAP2K6/IL1RAP/MAP3K14/FLT1/IKBKG/GADD45B/DUSP7/TGFB2/BRAF/TGFB3/RASGRF1/MAP3K6/PGF/PPP3CA/DUSP4/MECOM/ECSIT	5.26533635565647
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	63/1827	180/9376	1.79616858237548	BST2/CCL2/IFNAR2/HLA-C/HLA-F/PIK3R3/B2M/IRF7/TICAM1/HLA-A/TNFRSF1A/PPP1CA/PPP1CC/ITGA5/IFIH1/BIRC2/EIF2S1/HLA-E/BAX/OAS2/IFNAR1/CYCS/TAPBPL/EIF2AK2/BCL2L1/SRSF9/MYD88/SRSF2/IFNGR1/IL6/RELA/SRSF8/TRAF6/HLA-DMA/EIF4EBP1/IRF9/MAP3K7/EIF2B2/SOCS3/SP100/RHEB/CHUK/PPP1CB/HCFC1/MTOR/ALYREF/PML/TYK2/SRSF5/AKT3/OAS3/IRAK1/HLA-DRB1/CD74/PILRB/IKBKG/SRSF4/HLA-DRB5/OAS1/TAP2/JAK1/NFKBIA/HLA-B	5.30581381662305
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	81/1827	250/9376	1.66273891625616	GNS/AP1S2/NPC1/LAPTM4B/HYAL2/TPP1/ASAH1/ATP6V1F/BORCS7/ATP6V1A/CTSD/LAMTOR2/RRAGA/ATP6V0B/AGA/ATP6AP1/LAMTOR1/SCARB2/LIPA/NAGA/LAMTOR5/BLOC1S2/ARL8A/PLEKHM1/CLTB/HEXB/VPS29/LAMTOR4/ENTPD4/ACP2/VPS26A/ATP6V0C/ATP6V1E1/IGF2R/ATP6V1G1/PPT1/VAMP7/AP3M1/CTSO/CLN5/KXD1/CLN8/GLA/AP2S1/ACP5/MTOR/RRAGB/CTSF/CD68/GNPTG/CLN3/AP5M1/TFEB/SNAPIN/GGA1/LAPTM4A/CTSL/AP1S1/HYAL1/AP4B1/GM2A/LAMP3/NCOA7/MFSD8/GPR155/TTI1/ATP6V0A2/TMEM175/OSBPL7/PPT2/AP3M2/BORCS6/ATP6V0E1/ATP6V1B2/OSBPL6/MCOLN3/OSBPL1A/AP4S1/SLC29A1/TELO2/CLN6	5.22495367824858
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	81/1827	250/9376	1.66273891625616	EHD4/ARPC5L/HSPA1B/CHMP1B/ARF6/HLA-C/HSPA1A/ARF3/SPG21/AGAP3/CAV2/HLA-F/RAB22A/CHMP5/EPN1/TGFBR1/HLA-A/LDLR/GIT1/WIPF1/SMAD2/SMAD3/CYTH2/VPS37B/HLA-E/MVB12A/SH3GL1/NEDD4/IQSEC1/PDCD6IP/ASAP2/RAB11FIP3/ARAP3/RAB11B/SNX3/ARF5/ARPC1A/RAB8A/CLTB/SH3GLB1/CBL/ARFGEF2/VPS29/DNM3/ARPC3/SMURF2/MVB12B/VPS26A/ARRB1/SMURF1/TRAF6/IGF2R/WWP1/PLD1/CAPZA2/CHMP1A/ASAP1/RAB11FIP5/VPS36/ACTR2/GRK5/RAB35/AP2S1/CYTH3/HRAS/PML/NEDD4L/ARPC1B/WASHC2A/RAB11A/SH3GLB2/ACTR3/VTA1/CHMP4C/CYTH1/CHMP7/PRKCZ/PARD6G/HGS/IQSEC2/HLA-B	5.22495367824858
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	74/1827	224/9376	1.69536320275237	ZFP36/ICAM1/CREB5/NFATC1/NFATC2/HLA-C/ADCY4/MSX1/ETS1/CDC26/FOSL1/CDKN1A/HLA-F/PIK3R3/B2M/KRAS/RANBP1/TGFBR1/SLC25A5/ANAPC16/HLA-A/TNFRSF1A/FDPS/CREB1/SMAD2/SMAD3/HLA-E/BAX/ELK4/ETS2/BUB3/MAPK3/TBPL1/NRAS/MAP2K4/STAT5A/VDAC3/MAP3K3/SMAD4/BCL2L1/IL6/CCND3/RELA/ANAPC10/HLA-DMA/MYC/MAPK8/CDKN2C/MAP3K1/CHUK/DLG1/HRAS/CANX/ATF6B/AKT3/ELK1/HLA-DRB1/KAT2A/MAP3K14/ADCY6/IKBKG/TBP/CD40/KAT5/CDK2/HLA-DRB5/TGFB2/ANAPC1/TGFB3/JAK1/NFKBIA/HLA-B/EGR2/PPP3CA	5.18188663453604
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	46/1827	119/9376	1.98376362039068	ICAM1/CREB5/CCL2/JAG1/EDN1/MMP9/CXCL2/PIK3R3/BCL3/SELE/RPS6KA5/MAP2K3/TNFRSF1A/CXCL3/CREB1/BIRC2/CFLAR/MAP3K8/TNFAIP3/MAPK3/DAB2IP/MAP2K4/TNFRSF1B/MAPK14/IL6/RELA/MAPK8/MLKL/MAPK12/MAP3K7/SOCS3/CHUK/CSF1/FRMD8/ATF6B/AKT3/JUNB/CXCL1/MAP2K6/MAP3K14/IKBKG/IL18R1/RHBDF1/NFKBIA/CX3CL1/BAG4	5.31299376585462
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	51/1827	138/9376	1.89657552176293	CCL2/NFATC1/NFATC2/ARPC5L/ARF6/PIK3R3/RPS6KA2/TICAM1/MAP2K3/PXN/ITGA5/RAC1/WIPF1/SKAP2/RHOG/RPS6KA3/BCAR1/CRK/MAPK3/MAP2K4/ARPC1A/MAPK14/ARPC3/MYD88/IL6/VAV2/RELA/TRAF6/MAPK8/MAPK12/MAP3K7/ACTR2/CHUK/ARHGEF7/PYCARD/ARPC1B/DOCK1/ARHGEF28/CASP1/AKT3/IRAK1/ARHGEF12/ACTR3/MAP2K6/WASF2/LAT/IKBKG/NFKBIA/PTK2/VAV3/FN1	5.21972521815788
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	84/1827	268/9376	1.6085091782467	TUBB6/GNAI2/NDUFB4/UBE2J1/ADRM1/NDUFC2/CALML4/SLC39A8/NDUFC1/NDUFS7/NDUFB3/COX7A2/MAOA/ATP5F1C/SLC25A5/COX8A/UQCRFS1/NDUFB9/NDUFA12/DUSP1/PINK1/COX5A/NDUFA8/PSMD7/KLC1/EIF2S1/NDUFS8/COX7A1/TUBB2A/BAX/NDUFS2/COX6B1/COX6A1/COX5B/CYCS/UQCR11/NDUFS6/PSMC6/NDUFA7/UQCRQ/VDAC3/UQCRH/SDHD/NDUFA2/SNCA/NDUFAB1/PSMB2/ATP5MC1/BCL2L1/UQCR10/NDUFA3/PSMB6/PSMA4/NDUFB11/COX7C/UBE2G2/MAPK8/SLC39A10/TUBA1A/PSMD6/SLC39A7/RPS27A/ATP5MC2/SLC39A4/COX7B/GNAI3/NDUFA13/CYC1/UQCRB/ATP5PF/ATF6/NDUFB2/CALM1/TUBA4A/PSMA2/NDUFA4/PSMA7/MT-ND4/MT-CO2/UBA52/UQCRC1/CAMK2G/GNAS/CALM2	4.97202402367674
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	113/1827	388/9376	1.49460272318431	TUBB6/NOX4/NDUFB4/ADRM1/NDUFC2/CALML4/APH1A/SLC39A8/NDUFC1/NDUFS7/PIK3R3/NDUFB3/COX7A2/BACE2/KRAS/ATP5F1C/SLC25A5/COX8A/TNFRSF1A/FZD6/UQCRFS1/NDUFB9/NDUFA12/COX5A/NDUFA8/PSMD7/KLC1/EIF2S1/NDUFS8/COX7A1/CSNK1E/TUBB2A/NDUFS2/COX6B1/COX6A1/NCSTN/COX5B/CSNK2B/CYCS/UQCR11/NDUFS6/MAPK3/NRAS/HSD17B10/PSMC6/ATG2B/NDUFA7/UQCRQ/VDAC3/UQCRH/SDHD/NDUFA2/EIF2AK2/SNCA/NDUFAB1/PSMB2/APP/ATP5MC1/UQCR10/NDUFA3/PSMB6/AXIN2/IL6/PSMA4/RELA/NDUFB11/COX7C/MAPK8/SLC39A10/TUBA1A/PSMD6/SLC39A7/ATP5MC2/SLC39A4/ATG101/COX7B/NDUFA13/MME/CYC1/CHUK/CHRNA7/LRP6/LRP5/UQCRB/ATP5PF/ATF6/MTOR/CSF1/HRAS/NDUFB2/RTN4/CALM1/CDK5/TUBA4A/AKT3/ARAF/PSMA2/FZD4/NDUFA4/WNT2B/PIK3R4/WNT6/IKBKG/AXIN1/PSMA7/MT-ND4/MT-CO2/BRAF/UQCRC1/GRM5/GAPDH/CALM2/PPP3CA	4.89498125774988
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	57/1827	163/9376	1.79459437678181	CREB5/NFATC1/NFATC2/MMP9/CDKN1A/PIK3R3/IRF7/EGR3/KRAS/TICAM1/TGFBR1/MAP2K3/IFIH1/CREB1/ATP6AP1/SMAD3/BAX/IFNAR1/CYCS/MAPK3/NRAS/MAP2K4/HSPG2/STAT5A/SOS2/VDAC3/MAPK14/SMAD4/MYD88/IL6/RELA/TRAF6/MYC/MAPK8/DDB2/MAP3K1/MAPK12/MAP3K7/CHUK/HRAS/ATF6B/TYK2/AKT3/ARAF/IRAK1/ELK1/MAP2K6/IKBKG/PCNA/CDK2/TIRAP/TGFB2/BRAF/TGFB3/JAK1/NFKBIA/EGR2	5.03441430898871
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	93/1827	308/9376	1.54957029833877	POLR2J/CREB5/POLR2K/TUBB6/NDUFB4/ADRM1/NDUFC2/NDUFC1/NDUFS7/NDUFB3/COX7A2/ATP5F1C/SLC25A5/POLR2I/COX8A/UQCRFS1/NDUFB9/NDUFA12/POLR2F/CREB1/COX5A/NDUFA8/PSMD7/KLC1/NDUFS8/COX7A1/TFAM/TUBB2A/BAX/NDUFS2/COX6B1/COX6A1/COX5B/POLR2G/HTT/CYCS/UQCR11/NDUFS6/TBPL1/POLR2E/PSMC6/ATG2B/NDUFA7/UQCRQ/CLTB/VDAC3/UQCRH/SDHD/NDUFA2/NDUFAB1/PSMB2/ATP5MC1/UQCR10/NDUFA3/PSMB6/ACTR10/PSMA4/NDUFB11/HDAC1/COX7C/SIN3A/HIP1/MAPK8/SP1/HDAC2/TUBA1A/GPX7/PSMD6/DCTN6/ATP5MC2/ATG101/COX7B/NDUFA13/CYC1/UQCRB/ATP5PF/AP2S1/MTOR/NDUFB2/TUBA4A/PSMA2/NDUFA4/PIK3R4/POLR2L/TBP/PSMA7/MT-ND4/MT-CO2/UQCRC1/GRM5/SLC1A2/DNAL1/BBC3	4.82450826618483
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	42/1827	110/9376	1.9594566353187	ID3/ID1/SMAD9/SKIL/RBX1/LTBP1/PPP2R1A/TGFBR1/PPP2R1B/BMP6/LRRC32/SMAD2/SMAD3/SMAD6/SMAD1/E2F4/THBS1/SMAD5/MAPK3/TGIF1/SMAD4/SMURF2/SMURF1/HDAC1/MYC/SIN3A/TGIF2/SP1/ACVR1/HDAC2/CUL1/TFDP1/BMP2/FST/CHRD/ACVR2B/RGMB/TGFB2/TGFB3/E2F5/BAMBI/RPS6KB2	4.97950008922775
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	50/1827	142/9376	1.807010646253	MGST2/KLF2/CDH5/ICAM1/CCL2/KDR/MGST3/THBD/EDN1/MMP9/CALML4/CAV2/PIK3R3/SELE/PECAM1/SUMO1/SUMO3/TNFRSF1A/RAC1/DUSP1/NQO1/PRKAA1/ARHGEF2/MAP2K4/MAPK14/RELA/MAPK8/ACVR1/PDGFB/MAPK12/MAP3K7/CHUK/MEF2A/NOS3/MEF2C/PDGFA/MAPK7/CALM1/AKT3/CTSL/MAP2K6/IKBKG/ACVR2B/PRKCZ/SUMO4/PTK2/SUMO2/CALM2/HSP90B1/GSTM4	4.76692918515196
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	30/1827	71/9376	2.1684127755036	CXCL2/HBEGF/NOD1/ATP6V1F/ATP6V1A/F11R/GIT1/CXCL3/RAC1/ATP6V0B/ATP6AP1/JAM2/MAP2K4/MAPK14/ATP6V0C/RELA/ATP6V1E1/MAPK8/ATP6V1G1/MAPK12/CHUK/MET/JAM3/CXCL1/MAP3K14/IKBKG/ATP6V0A2/NFKBIA/ATP6V0E1/ATP6V1B2	4.8615805042463
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	68/1827	216/9376	1.61560137039064	APOA1/LY96/ICAM1/CCL2/NFATC1/NFATC2/HSPA1B/HSPA1A/MMP9/CXCL2/CALML4/PIK3R3/SELE/IRF7/KRAS/TICAM1/MAP2K3/TNFRSF1A/LDLR/CXCL3/RAC1/ABCG1/EIF2S1/ERO1A/BAX/TNFSF10/CYCS/MAPK3/NRAS/MAP2K4/MIB1/MAPK14/BCL2L1/MYD88/IL6/VAV2/RELA/TNFRSF10B/TRAF6/MAPK8/MAPK12/MAP3K7/TNFRSF10A/RAP1A/CHUK/ATF6/PYCARD/HRAS/NOS3/CALM1/CASP1/HSPA2/AKT3/CXCL1/IRAK1/MAP2K6/IKBKG/CD40/TIRAP/RXRB/NFKBIA/CAMK2G/MMP1/PTK2/CALM2/VAV3/PPP3CA/HSP90B1	4.50286488866917
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	34/1827	87/9376	2.00557411496769	LEF1/CDKN1A/RALGDS/PMAIP1/PIK3R3/KRAS/TGFBR1/RAC1/SMAD2/SMAD3/BAX/CYCS/MAPK3/NRAS/SOS2/SMAD4/AXIN2/MYC/MAPK8/RALA/DDB2/MTOR/HRAS/POLK/AKT3/ARAF/TCF7L1/AXIN1/GADD45B/TGFB2/BRAF/TGFB3/BBC3/RPS6KB2	4.63553035653505
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	63/1827	200/9376	1.61655172413793	CLDN5/TUBB6/ARPC5L/MYO1D/ARF6/NCKAP1/GNA13/TNFRSF1A/RAC1/WIPF1/MYO1B/CYTH2/TMBIM6/TUBB2A/BAX/ABI1/TNFSF10/ARHGEF2/CYCS/MAPK3/ARPC1A/SEC24B/MAPK14/MYO6/ARPC3/MYD88/IL6/RELA/TNFRSF10B/TRAF6/BRK1/MAPK8/GNA12/TUBA1A/MAPK12/MAP3K7/TNFRSF10A/HCLS1/ACTR2/MYH10/CHUK/PYCARD/CYTH3/ARPC1B/CASP1/NCK2/TUBA4A/CLDN15/IRAK1/ARHGEF12/ACTR3/WASF2/CYTH1/IKBKG/TIRAP/TLR5/WASF1/CLDN10/NFKBIA/MYO1E/GAPDH/CLDN3/WASF3	4.3357877212682
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	95/1827	333/9376	1.46405847555273	ISG15/CREB5/BCAP31/IFNAR2/JAG1/ITGA6/HLA-C/ITGA2/CDKN1A/HLA-F/PIK3R3/ATP6V1F/PPP2R1A/KRAS/TICAM1/ATP6V1A/HLA-A/NOTCH4/TNFRSF1A/PXN/FZD6/PPP2R1B/NOTCH1/ITGA5/ATP6V0B/LAMA5/CREB1/ITGA1/ATP6AP1/HLA-E/HES4/VWF/BAX/THBS1/PPP2R3C/IFNAR1/MAPK3/TBPL1/NRAS/SOS2/EIF2AK2/MX1/AXIN2/ATP6V0C/CCND3/RELA/ATP6V1E1/HDAC1/EIF4EBP1/ATP6V1G1/HDAC2/ITGA3/UBR4/IRF9/PKM/RHEB/CHUK/PPP2R2A/MTOR/DLG1/LAMA4/HRAS/MFNG/TYK2/AKT3/ITGA8/FZD4/TUBG1/WNT2B/LFNG/TCF7L1/WNT6/PPP2R5B/IKBKG/TBP/PRKCZ/AXIN1/CDK2/PARD6G/ITGB4/RELN/ATP6V0A2/JAK1/ATP6V0E1/ATP6V1B2/VTN/GNAS/PTK2/HLA-B/DLG2/HEY1/FN1/ITGA9/RPS6KB2/LAMC2	4.24178605044429
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	52/1827	157/9376	1.69974096967288	IGFBP3/NFATC1/NFATC2/HLA-C/ETS1/CALML4/CDKN1A/HLA-F/PIK3R3/KRAS/TGFBR1/MAP2K3/SLC25A5/HLA-A/HIPK1/PPP1CA/PPP1CC/SERPINE1/SMAD2/SMAD3/HLA-E/E2F4/MAPK3/NRAS/VDAC3/MAPK14/ZFP36L1/IL6/CCND3/RELA/MYC/EIF4EBP1/MAPK12/RHEB/MRAS/PPP1CB/MTOR/HRAS/CALM1/AKT3/ZFP36L2/MAP2K6/HIPK3/CDK2/GADD45B/TGFB2/TGFB3/HLA-B/CALM2/E2F5/LIN37/PPP3CA	4.34966109803228
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	35/1827	93/9376	1.93136406707041	CDH5/ARHGAP29/PTPRB/HEG1/LEF1/RASIP1/FGFR1/AFDN/TGFBR1/RAC1/PDCD10/SMAD3/MYL12A/CSNK2B/MAPK3/PTPN1/SMAD4/SMURF2/SMURF1/ACTN4/IQGAP1/MAP3K7/NLK/RAP1A/YES1/CTNNA1/MET/TCF7L1/WASF2/NECTIN3/WASF1/LMO7/SNAI1/MYL12B/WASF3	4.44044992271506
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	64/1827	205/9376	1.60215734177046	ISG15/ICAM1/IFNAR2/HLA-C/ADRM1/CDKN1A/HLA-F/PIK3R3/B2M/IRF7/MAP2K3/CD58/HLA-A/RAC1/PSMD7/HLA-E/BAX/OAS2/NEDD4/ENTPD1/IFNAR1/TNFAIP3/CYCS/TAPBPL/MAP2K4/PSMC6/EIF2AK2/MAPK14/MYD88/IL6/CCND3/RELA/HDAC1/TRAF6/HLA-DMA/MYC/SIN3A/MAPK8/HDAC2/PSMD6/IRF9/DDB2/MAPK12/MAP3K7/CHUK/POLK/TYK2/AKT3/OAS3/IRAK1/HLA-DRB1/MAP2K6/MAP3K14/IKBKG/CD40/CDK2/HLA-DRB5/NFKBIE/GADD45B/OAS1/TAP2/JAK1/NFKBIA/HLA-B	4.28833563405321
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	55/1827	170/9376	1.66032389967481	CLDN5/ARPC5L/AFDN/SYNPO/PPP2R1A/MSN/F11R/PPP2R1B/AMOTL2/RAC1/MPDZ/JAM2/MYL12A/NEDD4/PRKAA1/CGNL1/ARHGEF2/ARPC1A/RAB8A/ARHGAP17/ARPC3/ACTN4/MAPK8/TUBA1A/MAP3K1/RAP1A/TJP2/AMOTL1/HCLS1/YBX3/PRKCE/ACTR2/MYH10/PPP2R2A/DLG1/NEDD4L/PRKAG2/PRKAG1/ARPC1B/RAPGEF2/JAM3/TUBA4A/CLDN15/ACTR3/PCNA/PRKCZ/PARD6G/CLDN10/RAB13/TJAP1/DLG2/CLDN3/PRKAB2/MYL12B/MICALL2	4.27421329594811
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	30/1827	77/9376	1.99944554624358	CDKN1A/RALGDS/PIK3R3/KRAS/TGFBR1/RAC1/SMAD2/RALBP1/SMAD3/BAX/MAPK3/SMAD4/BCL2L1/RELA/MAPK8/RALA/PLD1/DDB2/CHUK/MTOR/POLK/AKT3/ARAF/IKBKG/GADD45B/TGFB2/BRAF/TGFB3/JAK1/RPS6KB2	4.33208106575498
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	61/1827	196/9376	1.5971761446779	ZFP36/ICAM1/ANGPT2/NFATC1/NFATC2/LEF1/IFNAR2/HLA-C/GNG12/GNG5/CXCL2/GNG11/CALML4/CDKN1A/HLA-F/PIK3R3/GNG10/IRF7/KRAS/TICAM1/HLA-A/TNFRSF1A/CXCL3/RAC1/CREB1/HLA-E/BAX/IFNAR1/GNB4/CYCS/MAPK3/NRAS/MAP2K4/EIF2AK2/MAPK14/IFNGR1/IL6/RELA/MYC/MAPK8/PDGFB/IRF9/MAPK12/RPS27A/CHUK/MTOR/HRAS/CALM1/TYK2/AKT3/CXCL1/PREX1/TCF7L1/MAP2K6/IKBKG/UBA52/JAK1/NFKBIA/HLA-B/CALM2/PPP3CA	4.15641922528032
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	102/1827	368/9376	1.4224316413222	TUBB6/NXT1/NDUFB4/ADRM1/NDUFC2/NDUFC1/NDUFS7/NDUFB3/COX7A2/NUP54/ATP5F1C/MAP2K3/COX8A/TNFRSF1A/ANXA11/UQCRFS1/NDUFB9/NDUFA12/RAC1/PINK1/COX5A/NDUFA8/PSMD7/KLC1/EIF2S1/NDUFS8/COX7A1/TUBB2A/BAX/NDUFS2/COX6B1/COX6A1/COX5B/CYCS/UQCR11/NDUFS6/ATXN2L/PSMC6/ATG2B/NDUFA7/RAB8A/UQCRQ/UQCRH/SDHD/NDUFA2/TNFRSF1B/NDUFAB1/PSMB2/PFN1/MAPK14/UBQLN1/ATP5MC1/BCL2L1/UQCR10/NDUFA3/PSMB6/ACTR10/PSMA4/NDUFB11/COX7C/NUP50/TUBA1A/GPX7/PSMD6/DCTN6/MAPK12/ATP5MC2/ATG101/COX7B/NUP160/NDUFA13/VCP/CYC1/UQCRB/ALS2/ATP5PF/NUP88/ATF6/MTOR/ALYREF/NDUFB2/RAE1/CASP1/TUBA4A/PSMA2/SEH1L/NDUFA4/MAP2K6/PIK3R4/NUP35/SIGMAR1/NUP93/PSMA7/C9orf72/MT-ND4/MT-CO2/UQCRC1/NRG3/SLC1A2/HDAC6/DNAL1/PPP3CA	4.06702048978383
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	127/1827	480/9376	1.35781791643861	TUBB6/NOX4/NDUFB4/UBE2J1/ADRM1/NDUFC2/CALML4/NDUFC1/NDUFS7/NDUFB3/COX7A2/KRAS/ATP5F1C/MAP2K3/SLC25A5/COX8A/TNFRSF1A/FZD6/UQCRFS1/NDUFB9/NDUFA12/RAC1/PINK1/COX5A/NDUFA8/PSMD7/KLC1/ATXN3/EIF2S1/NDUFS8/COX7A1/CSNK1E/TUBB2A/BAX/NDUFS2/COX6B1/COX6A1/COX5B/HTT/CSNK2B/CYCS/UQCR11/NDUFS6/MAPK3/ATXN2L/NRAS/HSD17B10/PSMC6/ATG2B/NDUFA7/RAB8A/UQCRQ/VDAC3/UQCRH/SDHD/NDUFA2/TNFRSF1B/SNCA/NDUFAB1/PSMB2/MAPK14/APP/ATP5MC1/BCL2L1/UQCR10/NDUFA3/PSMB6/AXIN2/IL6/ACTR10/PSMA4/RELA/NDUFB11/COX7C/UBE2G2/HIP1/MAPK8/TUBA1A/GPX7/PSMD6/DCTN6/MAPK12/RPS27A/ATP5MC2/ATG101/COX7B/NDUFA13/VCP/CYC1/CHRNA7/LRP6/LRP5/UQCRB/ALS2/ATP5PF/ATF6/MTOR/CSF1/HRAS/NDUFB2/CALM1/CDK5/RYR2/TUBA4A/ARAF/PSMA2/ATXN1L/FZD4/NDUFA4/WNT2B/MAP2K6/PIK3R4/WNT6/SIGMAR1/AXIN1/PSMA7/C9orf72/MT-ND4/MT-CO2/BRAF/UBA52/UQCRC1/CAMK2G/GRM5/CALM2/DNAL1/PPP3CA	3.95909126531054
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	39/1827	112/9376	1.7870044569552	LY96/HSPA1B/GNAI2/ITGA6/HSPA1A/IL10RB/MAP2K3/TNFRSF1A/LDLR/LAMA5/BIRC2/CYCS/MAPK3/MAPK14/BCL2L1/MYD88/IFNGR1/RELA/TRAF6/HLA-DMA/MAPK8/MAPK12/MAP3K7/GNAI3/CHUK/LAMA4/TYK2/AKT3/IRAK1/HLA-DRB1/MAP2K6/IKBKG/CD40/HLA-DRB5/TGFB2/TGFB3/JAK1/NFKBIA/LAMC2	4.12189694284631
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	79/1827	275/9376	1.47425784943026	CREB5/TUBB6/HSPA1B/NDUFB4/HSPA1A/ADRM1/NDUFC2/CAV2/NDUFC1/NDUFS7/PIK3R3/NDUFB3/COX7A2/ATP5F1C/SLC25A5/COX8A/UQCRFS1/NDUFB9/NOTCH1/NDUFA12/RAC1/CREB1/COX5A/NDUFA8/PSMD7/KLC1/EIF2S1/NDUFS8/COX7A1/TUBB2A/BAX/NDUFS2/COX6B1/COX6A1/COX5B/CSNK2B/CYCS/UQCR11/NDUFS6/MAPK3/PSMC6/NDUFA7/UQCRQ/VDAC3/UQCRH/SDHD/NDUFA2/NDUFAB1/PSMB2/MAPK14/ATP5MC1/UQCR10/NDUFA3/PSMB6/IL6/PSMA4/NDUFB11/COX7C/MAPK8/TUBA1A/PSMD6/MAPK12/ATP5MC2/COX7B/NDUFA13/CYC1/UQCRB/ATP5PF/NDUFB2/ATF6B/RYR2/TUBA4A/PSMA2/NDUFA4/PSMA7/MT-ND4/MT-CO2/UQCRC1/PPP3CA	3.92686993179753
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	68/1827	232/9376	1.50418058622577	SCIN/RGCC/ARPC5L/ITGA6/GNG12/ITGA2/FGFR1/PIK3R3/NCKAP1/KRAS/MSN/GNA13/PXN/GIT1/PPP1CA/PPP1CC/ITGA5/RAC1/ITGA1/BCAR1/MYL12A/MYLK/CRK/ITGAE/MAPK3/NRAS/ARPC1A/SOS2/PFN1/DIAPH1/ARPC3/VAV2/ACTN4/BRK1/GNA12/ITGA3/PDGFB/SSH1/IQGAP1/ACTR2/MYH10/MRAS/PPP1CB/ARHGEF7/HRAS/PDGFA/ARPC1B/PDGFD/DOCK1/PAK4/AKT3/ABI2/ARAF/ITGA8/SSH2/ARHGEF12/ACTR3/WASF2/ITGB4/CFL1/BRAF/WASF1/DIAPH2/PTK2/VAV3/MYL12B/FN1/ITGA9	3.82535902665271
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	61/1827	203/9376	1.54210110520625	KDR/EMP1/ITGA6/ITGA2/EMP2/SHC1/CAV2/PIK3R3/RAPGEF1/PXN/PPP1CA/PPP1CC/ITGA5/RAC1/LAMA5/ITGA1/BIRC2/PARVB/BCAR1/VWF/MYL12A/MYLK/THBS1/CRK/FLNB/MAPK3/SOS2/DIAPH1/FLT4/CCND3/VAV2/ACTN4/MAPK8/ITGA3/PDGFB/RAP1A/SHC2/PPP1CB/LAMA4/HRAS/PDGFA/MET/PDGFD/DOCK1/PAK4/AKT3/ITGA8/ELK1/FLT1/ITGB4/RELN/BRAF/VTN/RASGRF1/PTK2/PGF/VAV3/MYL12B/FN1/ITGA9/LAMC2	3.84134057917902
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	73/1827	253/9376	1.48074880308763	ARPC5L/ARF6/BCL10/TIFA/RBX1/NOD1/PIK3R3/RPS6KA5/TNFRSF1A/PXN/UBE2N/ITGA5/RRAGA/RAC1/CAPNS1/BCAR1/CYTH2/MYL12A/BAX/CRK/ARHGEF2/UBE2D2/CYCS/MAPK3/RBCK1/ARPC1A/RIPK2/PFN1/MAPK14/DIAPH1/ARPC3/BCL2L1/MYD88/RELA/TRAF6/ACTN4/MAPK8/CUL1/MAPK12/MAP3K7/RPS27A/HCLS1/UBE2V1/PRKCE/MALT1/ACTR2/CHUK/MTOR/PYCARD/CYTH3/RRAGB/U2AF1/ARPC1B/DOCK1/CASP1/SEPTIN8/AKT3/FNBP1L/ACTR3/PIK3R4/WASF2/CYTH1/IKBKG/TLR5/CAST/UBA52/WASF1/SEPTIN7/NFKBIA/PTK2/MYL12B/UBE2D4/RPS6KB2	3.81346560777626
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	29/1827	78/9376	1.90801790801791	ARPC5L/SHC1/CAV2/PIK3R3/PXN/CD2AP/ITGA5/RAC1/RHOG/BCAR1/CRK/ARPC1A/CLTB/CBL/DNM3/ARPC3/CTNNA1/HCLS1/ACTR2/SHC2/MET/ARPC1B/DOCK1/SEPTIN8/ACTR3/WASF2/WASF1/PTK2/FN1	3.96147704216868
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	16/1827	34/9376	2.41501658134518	NR1D2/PER1/RBX1/BHLHE40/CRY2/NR1D1/PER3/CREB1/PER2/CSNK1E/PRKAA1/CUL1/FBXL3/PRKAG2/PRKAG1/PRKAB2	4.06622358695304
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	53/1827	173/9376	1.57220371372255	ICAM1/CCL2/IFNAR2/NXT1/PIK3R3/KPNA1/IRF7/TICAM1/SLC25A5/TNFRSF1A/FDPS/IFIH1/EIF2S1/BAX/OAS2/TNFSF10/IFNAR1/CYCS/MAPK3/RAB11B/ADAR/EIF2AK2/PABPN1/MX1/MYD88/IFNGR1/IL6/CCND3/RELA/TNFRSF10B/HLA-DMA/IRF9/TNFRSF10A/SOCS3/IL33/CHUK/RSAD2/PYCARD/PML/PRSS3/RAE1/CASP1/TYK2/AKT3/RAB11A/DNAJB1/OAS3/HLA-DRB1/IKBKG/HLA-DRB5/OAS1/JAK1/NFKBIA	3.73696656233327
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	30/1827	83/9376	1.854907313985	CBX4/MAX/PCGF2/SCML1/CSNK2B/RYBP/UBE2D2/YAF2/DCAF7/SUZ12/E2F6/HDAC1/FOXK1/HDAC2/YY1/TFDP1/FBRS/RING1/MBD6/HCFC1/TEX10/PHF1/ASXL2/PHC1/FBRSL1/L3MBTL3/BAP1/SCML2/PCGF1/UBE2D4	3.84848953035625
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	44/1827	138/9376	1.63626123446213	SHC1/CALML4/PIK3R3/RAPGEF1/KRAS/PPP1CA/PRKAR1A/PPP1CC/PRKAR2B/EIF4E/CRK/PRKAA1/MAPK3/FLOT2/NRAS/SOS2/CBL/G6PC3/PTPN1/MKNK2/MAPK8/EIF4EBP1/INPP5A/SOCS3/SOCS4/RHEB/SHC2/PPP1CB/MTOR/HRAS/TRIP10/PRKAG2/PRKAG1/CALM1/AKT3/ARAF/ELK1/PRKCZ/BRAF/ACACB/PRKAR1B/CALM2/PRKAB2/RPS6KB2	3.70421535079164
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	22/1827	56/9376	2.01610759246227	TUSC3/RPN1/KRTCAP2/MGAT4A/B4GALT3/DAD1/RPN2/MAGT1/DPM3/ALG5/DPM1/STT3B/MGAT4B/MGAT5/MAN1A2/ALG2/ALG3/DOLK/ALG8/MAN2A2/MOGS/ALG12	3.75176781115486
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	65/1827	227/9376	1.4694897149705	CREB5/CCL2/NFATC1/NFATC2/GNAI2/HLA-C/GNG12/ADCY4/GNG5/IL10RB/GNG11/CALML4/CDKN1A/HLA-F/PIK3R3/GNG10/B2M/KRAS/GNA13/HLA-A/TNFRSF1A/PXN/RAC1/CREB1/BCAR1/HLA-E/BAX/CRK/GNB4/CYCS/TAPBPL/MAPK3/NRAS/SOS2/MAPK14/IL6/RELA/MYC/SP1/GNA12/EIF4EBP1/MAPK12/GNAI3/RHEB/CHUK/MTOR/HRAS/ATF6B/CALM1/AKT3/ELK1/ARHGEF12/MAP2K6/ADCY6/IKBKG/TAP2/JAK1/NFKBIA/GNAS/PTK2/HLA-B/CALM2/CX3CL1/PPP3CA/RPS6KB2	3.52259242361236
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	46/1827	149/9376	1.58434812635229	FCER1A/ARF6/PLPP2/ADCY4/SHC1/RALGDS/PIK3R3/KRAS/GNA13/RAPGEF4/CYTH2/DGKZ/AGPAT1/AGPAT4/DGKD/MAPK3/NRAS/SOS2/DGKH/DNM3/PLPP3/GNA12/RALA/PLD1/LPAR6/PDGFB/RHEB/SHC2/MRAS/MTOR/CYTH3/HRAS/AGPAT2/PDGFA/PDGFD/AKT3/KITLG/CYTH1/ADCY6/RAPGEF3/AVPR2/GRM5/GNAS/SPHK1/GRM2/DGKQ	3.53707874868444
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	40/1827	125/9376	1.64221127531472	S1PR1/FCER1A/GNAI2/ASAH1/PIK3R3/PPP2R1A/KRAS/GNA13/CTSD/TNFRSF1A/PPP2R1B/RAC1/SGMS1/NSMAF/BAX/DEGS1/PPP2R3C/ORMDL2/MAPK3/NRAS/SPTLC1/CERS2/MAPK14/RELA/MAPK8/GNA12/PLD1/MAPK12/GNAI3/PRKCE/PPP2R2A/CERS5/HRAS/NOS3/AKT3/PPP2R5B/SGPL1/PRKCZ/SPHK1/SGMS2	3.55589387808838
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	52/1827	174/9376	1.53367432321059	TUSC3/BCAP31/HSPA1B/HSPA1A/TRAM1/UBE2J1/RPN1/RBX1/KRTCAP2/BCAP29/DNAJB11/DAD1/SVIP/NSFL1C/SELENOS/RPN2/PLAA/NPLOC4/ATXN3/EIF2S1/ERO1A/MAGT1/BAX/UBE2D2/ERP29/SEC61G/SEC24B/UBE4B/UBQLN1/SSR1/SEC62/STT3B/UBE2G2/MAPK8/CUL1/TXNDC5/MAN1A2/SSR4/VCP/EDEM3/ATF6/CANX/PPP1R15A/ATF6B/HYOU1/DNAJB1/YOD1/WFS1/SYVN1/MOGS/HSP90B1/UBE2D4	3.49558620573699
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	48/1827	158/9376	1.5590613373241	SGK1/SLC3A2/PIK3R3/ATP6V1F/RPS6KA2/KRAS/ATP6V1A/TNFRSF1A/LAMTOR2/FZD6/RRAGA/LAMTOR1/RPS6KA3/LAMTOR5/EIF4E/PRKAA1/MAPK3/NRAS/SOS2/CASTOR1/GRB10/LAMTOR4/ATP6V1E1/PRR5/EIF4EBP1/ATP6V1G1/FNIP2/RHEB/CHUK/LRP6/LRP5/MTOR/HRAS/RRAGB/AKT3/FZD4/SEH1L/WNT2B/WNT6/NPRL3/STRADA/BRAF/TTI1/STRADB/ATP6V1B2/PRR5L/TELO2/RPS6KB2	3.48642116855662
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	44/1827	142/9376	1.59016936870264	UBE2J1/CDC26/RBX1/UBA6/ANAPC16/UBE2N/UBE2Q1/BIRC2/UBE2A/SIAH1/UBE2E3/NEDD4/UBE2D2/CBL/UBE4B/SMURF2/ANAPC10/SMURF1/TRAF6/UBE2G2/WWP1/CUL1/HERC1/PIAS3/DDB2/MAP3K1/RPS27A/UBA3/SOCS3/RNF7/CDC34/PRPF19/PML/NEDD4L/UBE2B/RHOBTB1/UBE2H/ANAPC1/UBA52/SYVN1/RHOBTB2/UBE2QL1/UBE2D4/CUL7	3.48606998050599
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	33/1827	99/9376	1.7106367451195	JAG1/JAG2/ADCY4/MMP9/SHC1/HBEGF/CDKN1A/PIK3R3/KRAS/NOTCH4/NOTCH1/BAX/MAPK3/NRAS/SOS2/MAPK14/MAPK8/SP1/CDKN2C/MAPK12/SHC2/MTOR/HRAS/AKT3/ARAF/ADCY6/GPER1/DLL1/BRAF/DLL4/GNAS/PTK2/RPS6KB2	3.49680712288717
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	33/1827	99/9376	1.7106367451195	LYPLA1/PLPP2/RALGDS/PIK3R3/KRAS/RAC1/DGKZ/DGKD/MAPK3/NRAS/SOS2/CHKA/DGKH/PLPP3/MAPK8/SP1/EIF4EBP1/PLD1/PDGFB/SLC44A4/RHEB/MTOR/HRAS/PDGFA/PDGFD/AKT3/SLC22A4/WASF2/CHPT1/WASF1/DGKQ/WASF3/RPS6KB2	3.49680712288717
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/1827	37/9376	2.21920442610098	LEF1/CDKN1A/KRAS/BAX/MAPK3/NRAS/TPM3/MYC/TFG/DDB2/HRAS/POLK/TCF7L1/GADD45B/RXRB/BRAF	3.65542101401691
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	61/1827	214/9376	1.46283422596668	TRIM5/BST2/AP1S2/NFATC1/NFATC2/GNAI2/HLA-C/GNG12/GNG5/GNG11/CALML4/RBX1/HLA-F/PIK3R3/GNG10/B2M/KRAS/MAP2K3/HLA-A/TNFRSF1A/PXN/RAC1/HLA-E/BAX/CRK/GNB4/CYCS/TAPBPL/MAPK3/NRAS/TNFRSF1B/MAPK14/BCL2L1/MYD88/RELA/TRAF6/MAPK8/CUL1/MAPK12/MAP3K7/GNAI3/RNF7/CHUK/MTOR/HRAS/PAK4/CALM1/AKT3/WEE1/AP1S1/IRAK1/MAP2K6/IKBKG/CFL1/TAP2/NFKBIA/PTK2/HLA-B/CALM2/PPP3CA/RPS6KB2	3.36935994844609
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	47/1827	156/9376	1.54615244270417	CLDN5/YWHAH/IFNAR2/CDKN1A/PIK3R3/YWHAG/IRF7/PPP2R1A/KRAS/TICAM1/TNFRSF1A/LDLR/PPP2R1B/EIF2S1/BAX/OAS2/CFLAR/IFNAR1/CYCS/MAPK3/NRAS/SOS2/EIF2AK2/MX1/RELA/TRAF6/MYC/IRF9/SOCS3/CHUK/RSAD2/PPP2R2A/HRAS/TYK2/AKT3/IFIT1/OAS3/ARAF/CLDN15/IKBKG/CDK2/OAS1/BRAF/CLDN10/JAK1/NFKBIA/CLDN3	3.38392647503962
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	43/1827	140/9376	1.57622957228869	KLF2/JAG1/GNAI2/GNG12/ADCY4/GNG5/GNG11/CALML4/GNG10/KRAS/TGFBR1/GNA13/CCN2/SERPINE1/SMAD2/SMAD3/MYLK/TFAM/PRKAA1/GNB4/MAPK3/NRAS/SMAD4/GNAI3/PRKCE/MEF2A/MRAS/MTOR/HRAS/NOS3/MEF2C/PRKAG2/PRKAG1/CALM1/RYR2/AKT3/PIK3R4/ADCY6/CALM2/SPHK1/PRKAB2/PLIN1/RPS6KB2	3.37930816426634
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	38/1827	120/9376	1.62510490786353	SHC1/CALML4/PIK3R3/RAPGEF1/RPS6KA2/RPS6KA5/KRAS/SH2B3/RAC1/ARHGDIA/RPS6KA3/BAX/CRK/IRAK3/MAPK3/NRAS/SOS2/RIPK2/MAP3K3/MAPK14/ARHGDIB/RELA/TRAF6/MAPK8/MAP3K1/MAPK12/RAP1A/SHC2/HRAS/MAPK7/CALM1/AKT3/IRAK1/NFKBIE/BRAF/NFKBIA/CAMK2G/CALM2	3.39033066604949
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	14/1827	31/9376	2.31763688048449	SEC11C/GET1/SRP9/SRP19/SPCS1/SEC61G/SEC11A/SEC62/BAG6/OXA1L/SPCS3/GET3/IMMP1L/SRP14	3.61490705545321
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	47/1827	157/9376	1.53630433797357	ID1/YWHAH/LEF1/RASSF1/YWHAG/MOB1A/PPP2R1A/TGFBR1/FZD6/PPP1CA/PPP2R1B/PPP1CC/CCN2/BMP6/SERPINE1/TEAD4/BIRC2/FRMD6/SMAD2/SMAD3/SMAD1/CSNK1E/TEAD2/SMAD4/AXIN2/CCND3/MYC/CTNNA1/PPP1CB/PPP2R2A/DLG1/WTIP/BMP2/WWTR1/FZD4/WNT2B/TCF7L1/WNT6/PRKCZ/AXIN1/PARD6G/TGFB2/TGFB3/DLG2/NKD1/CRB2/BBC3	3.3337223582608
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	25/1827	70/9376	1.83282508405661	LEPR/TNFRSF1A/ADIPOR1/ACSL5/PRKAA1/TNFRSF1B/G6PC3/ADIPOR2/RELA/MAPK8/ACSL3/SOCS3/CHUK/MTOR/CPT1A/PRKAG2/PRKAG1/AKT3/IKBKG/NFKBIE/RXRB/ACACB/NFKBIA/POMC/PRKAB2	3.44057866865552
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	60/1827	212/9376	1.45242742510147	ID1/ANGPT2/KDR/EFNA1/GNAI2/ADCY4/FGFR1/CALML4/PRKD3/RALGDS/AFDN/PIK3R3/RAPGEF1/KRAS/MAP2K3/RAPGEF4/EPHA2/RAC1/PRKD2/BCAR1/THBS1/CRK/RASGRP2/EVL/MAPK3/ARAP3/NRAS/PFN1/MAPK14/FLT4/VAV2/RALA/PDGFB/MAPK12/RASGRP3/RAP1A/PRKD1/GNAI3/MRAS/CSF1/HRAS/PDGFA/MET/PDGFD/CALM1/RAPGEF2/AKT3/KITLG/MAP2K6/FLT1/ADCY6/LAT/RAPGEF3/PRKCZ/PARD6G/BRAF/GNAS/CALM2/PGF/VAV3	3.27781555883139
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	33/1827	101/9376	1.67676275016664	ICAM1/CCL2/NFATC1/THBD/NOX4/EDN1/PIK3R3/SELE/KRAS/TGFBR1/RAC1/SERPINE1/SMAD2/SMAD3/BAX/MAPK3/NRAS/STAT5A/MAPK14/DIAPH1/SMAD4/IL6/RELA/MAPK8/MAPK12/PRKCE/HRAS/NOS3/AKT3/PRKCZ/TGFB2/TGFB3/FN1	3.36395651801083
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	34/1827	105/9376	1.66176140954466	GABARAPL2/CCZ1B/KRAS/FIS1/TBC1D15/FKBP8/PINK1/SIAH1/EIF2S1/CSNK2B/MON1B/CCZ1/NRAS/OPA1/BCL2L1/SMURF2/RELA/SMURF1/PHB2/MTX2/MAPK8/SP1/RPS27A/VCP/MRAS/HRAS/SAMM50/GABARAP/TFEB/FUNDC1/TOMM20/UBA52/RHOT2/ATG9A	3.35461740533541
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	66/1827	238/9376	1.42313477114984	ANGPT2/KDR/EFNA1/ARF6/RGL1/GNG12/GNG5/ETS1/GNG11/SHC1/FGFR1/CALML4/RASSF1/RALGDS/AFDN/PIK3R3/ABL2/GNG10/RASA2/KRAS/EPHA2/RAC1/RALBP1/RGL2/ETS2/RASGRF2/RASGRP2/GNB4/MAPK3/NRAS/SOS2/RALGAPB/FLT4/BCL2L1/PLA2G2A/RELA/MAPK8/RALA/PLD1/PDGFB/EXOC2/SHOC2/RASGRP3/RAP1A/CHUK/SHC2/MRAS/CSF1/HRAS/PDGFA/NF1/MET/PDGFD/PAK4/CALM1/PLA1A/AKT3/KITLG/ELK1/FLT1/LAT/IKBKG/RIN1/RASGRF1/CALM2/PGF	3.25275846578027
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	29/1827	86/9376	1.73052787006275	SHC1/HBEGF/CDKN1A/PIK3R3/ABL2/KRAS/CRK/MAPK3/NRAS/MAP2K4/STAT5A/SOS2/CBL/MYC/MAPK8/EIF4EBP1/SHC2/MTOR/HRAS/PAK4/NCK2/AKT3/ARAF/ELK1/BRAF/CAMK2G/NRG3/PTK2/RPS6KB2	3.34802241544243
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	24/1827	68/9376	1.81126243600889	DUSP6/LEF1/PIK3R3/KRAS/PER2/JUP/MAPK3/NRAS/STAT5A/SOS2/RELA/MYC/EIF4EBP1/RARA/CHUK/MTOR/HRAS/PML/AKT3/ARAF/TCF7L1/IKBKG/BRAF/RPS6KB2	3.3029183322416
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	34/1827	108/9376	1.61560137039064	RBM8A/IPO11/NXT1/MAGOH/KPNA4/KPNA1/NUP54/SUMO1/SUMO3/NUP42/KPNA3/UPF3A/PNN/TNPO1/XPO6/NUP50/AHCTF1/UPF3B/SAP18/DDX19B/TMEM33/NUP160/THOC1/NUP88/ALYREF/RAE1/SEH1L/PYM1/TNPO2/NUP35/XPOT/NUP93/SUMO4/SUMO2	3.16540032284927
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	34/1827	109/9376	1.60077933946963	CREB5/PIK3R3/RPS6KA2/TBC1D4/TNFRSF1A/PPP1CA/PPP1CC/CREB1/PTPA/RPS6KA3/NR1H2/PRKAA1/G6PC3/PTPN1/IL6/RELA/MAPK8/SOCS3/PRKCE/PPP1CB/MTOR/CPT1A/NOS3/PRKAG2/PRKAG1/AKT3/MLX/PRKCZ/ACACB/NFKBIA/SLC27A5/PRKAB2/SLC27A3/RPS6KB2	3.10362224306083
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	20/1827	55/9376	1.866149176494	PLPP2/ASAH1/SGMS1/DEGS1/KDSR/ACER3/HEXB/SPTLC1/CERS2/PLPP3/UGCG/GBA2/CERK/GLA/CERS5/B4GALT5/GM2A/SGPL1/SPHK1/SGMS2	3.16922436963027
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	21/1827	59/9376	1.82661211766998	LEF1/CDKN1A/PIK3R3/KRAS/BAX/MAPK3/NRAS/SOS2/AXIN2/MYC/DDB2/CTNNA1/HRAS/POLK/AKT3/ARAF/ELK1/TCF7L1/AXIN1/GADD45B/BRAF	3.13328518157765
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	29/1827	90/9376	1.65361552028219	NFATC1/NFATC2/PIK3R3/KRAS/TICAM1/MAP2K3/CSNK2B/MAPK3/NRAS/MAP3K3/MAPK14/MYD88/IFNGR1/RELA/TRAF6/MAPK12/CHUK/MTOR/HRAS/AKT3/MAP2K6/LAT/IKBKG/TIRAP/NFKBIE/JAK1/NFKBIA/PPP3CA/RPS6KB2	3.06506345734117
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	31/1827	98/9376	1.62335936016443	SCIN/MARCKSL1/ARPC5L/ARF6/PLPP2/PIK3R3/RAC1/CRK/ASAP2/MAPK3/ARPC1A/ARPC3/PLPP3/VAV2/PLD1/ASAP1/INPP5D/PRKCE/ACTR2/ARPC1B/DOCK1/AKT3/ACTR3/WASF2/LAT/CFL1/WASF1/VAV3/SPHK1/WASF3/RPS6KB2	3.05164870723625
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	32/1827	103/9376	1.59437987894633	CCL2/GNAI2/PIK3R3/PPP2R1A/TICAM1/TGFBR1/TNFRSF1A/PPP2R1B/SERPINE1/SMAD2/CFLAR/MAPK3/MAP2K4/MAPK14/MYD88/IFNGR1/IL6/RELA/TRAF6/MAPK8/MAPK12/GNAI3/CHUK/PPP2R2A/AKT3/IRAK1/IKBKG/ACE/TGFB2/TGFB3/NFKBIA/GNAS	2.9838898065782
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	51/1827	184/9376	1.4224316413222	PLXNA2/NFATC2/EFNA1/GNAI2/SEMA3B/RGS3/PIK3R3/SEMA3F/KRAS/EPHA2/EPHB4/RAC1/SEMA3A/RYK/SRGAP2/MYL12A/MAPK3/NRAS/FES/SEMA6B/SEMA6A/ABLIM2/SSH1/EPHA4/GNAI3/SRGAP1/UNC5B/HRAS/MET/PAK4/NCK2/CDK5/SEMA3C/SSH2/ARHGEF12/EFNB2/SEMA4A/PRKCZ/PARD6G/CFL1/UNC5A/SEMA7A/ABLIM3/ROBO3/CAMK2G/PTK2/SEMA6D/MYL12B/PPP3CA/EPHB6/SEMA3D	2.84688905975438
NA	NA	hsa04517	IgSF CAM signaling	77/1827	299/9376	1.32159561245019	ICAM1/ICAM2/KDR/TUBB6/PLXNA2/ARPC5L/ARF6/ROBO4/PMP22/FGFR1/ESAM/AFDN/PIK3R3/MSN/F11R/PXN/GIT1/CD2AP/CASKIN2/ITGA5/RAC1/MPDZ/SRGAP2/BCAR1/JAM2/MYL12A/MYLK/TUBB2A/MAPK3/EPB41L3/ARPC1A/MAPK14/APP/DYNLL2/ARPC3/VAV2/TRAF6/ACTN4/MAPK8/TUBA1A/IQGAP1/MAPK12/RAP1A/TJP2/INPP5D/SPTBN1/SRGAP1/ACTR2/SPTAN1/MYH10/UNC5B/CDH2/ARPC1B/PAK4/NCK2/RAPGEF2/JAM3/PVR/TUBA4A/AKT3/TRIO/ACTR3/IL1RAP/SCN8A/NECTIN3/DYNLL1/PARD6G/UNC5A/LMO7/ROBO3/PTK2/CADM3/MPP3/CXADR/VAV3/EPB41L1/MYL12B	2.78025570536951
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	32/1827	105/9376	1.56401073839498	NFATC1/NFATC2/PLK3/BCL10/CALML4/PIK3R3/BCL3/EGR3/KRAS/MAPK3/NRAS/MAPK14/IL6/RELA/MAPK8/IRF9/MAPK12/MALT1/CHUK/MRAS/PYCARD/HRAS/CALM1/CASP1/AKT3/ARHGEF12/MAP3K14/IKBKG/NFKBIA/EGR2/CALM2/PPP3CA	2.85909727059744
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	29/1827	93/9376	1.60027308414405	ITGA6/ITGA2/MAX/CDKN1A/PIK3R3/ZBTB17/LAMA5/BIRC2/BAX/CYCS/BCL2L1/RELA/TRAF6/MYC/TRAF4/ITGA3/DDB2/CHUK/LAMA4/POLK/AKT3/IKBKG/CDK2/GADD45B/RXRB/NFKBIA/PTK2/FN1/LAMC2	2.86191261219646
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	21/1827	62/9376	1.73822766036337	NRARP/JAG1/JAG2/SPEN/APH1A/NOTCH4/NOTCH1/NCSTN/HDAC1/HDAC2/DTX3L/MFNG/ATXN1L/LFNG/KAT2A/DTX3/CTBP2/DLL1/DLL4/HEY1/DTX2	2.86898475622618
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	23/1827	70/9376	1.68619907733208	ETS1/RBX1/CDKN1A/PIK3R3/RAPGEF1/KRAS/RAC1/EGLN2/CRK/MAPK3/NRAS/SOS2/PDGFB/RAP1A/HRAS/EPAS1/MET/PAK4/AKT3/ARAF/TGFB2/BRAF/TGFB3	2.83483525306423
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	8/1827	16/9376	2.56595511767926	NAGA/ST3GAL1/HEXB/A4GALT/GLA/ST8SIA1/B3GALNT1/FUT1	3.08398016807359
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	21/1827	63/9376	1.7106367451195	POLR2J/POLR2K/POLE4/RBX1/GTF2H5/POLR2I/POLR2F/POLR2G/POLR2E/RPA3/CCNH/DDB2/ERCC4/GTF2H3/RFC2/POLR2L/PCNA/RFC3/RPA1/GTF2H4/POLE	2.7840903972794
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	16/1827	44/9376	1.866149176494	TUSC3/RPN1/KRTCAP2/MGAT4A/B4GALT3/DAD1/RPN2/MAGT1/HEXB/STT3B/MGAT4B/MAN1A2/ALG2/ALG3/MAN2A2/ALG12	2.83296930618336
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	38/1827	133/9376	1.46626006724529	KLF2/S1PR1/SGK1/PLK3/GABARAPL2/CDKN1A/PIK3R3/KRAS/TGFBR1/PRMT1/SMAD3/CSNK1E/TNFSF10/PRKAA1/DEPP1/MAPK3/NRAS/SOS2/G6PC3/MAPK14/SMAD4/IL6/MAPK8/MAPK12/NLK/CHUK/HRAS/PRKAG2/PRKAG1/GABARAP/AKT3/ARAF/CDK2/GADD45B/TGFB2/BRAF/TGFB3/PRKAB2	2.66414442875523
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/1827	41/9376	1.87752813488726	MMP9/HBEGF/RASSF1/CDKN1A/RPS6KA5/KRAS/THBS1/MAPK3/NRAS/MYC/DAPK3/HRAS/ARAF/BRAF/MMP1	2.77016741166236
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	25/1827	80/9376	1.60372194854953	KDR/SHC1/PIK3R3/KRAS/EIF4E/BAX/MAPK3/NRAS/SOS2/BCL2L1/IL6/EIF4EBP1/PDGFB/SHC2/MTOR/HRAS/PDGFA/NF1/MET/PDGFD/AKT3/ARAF/BRAF/JAK1/RPS6KB2	2.66774368328382
Human Diseases	Cancer: specific types	hsa05214	Glioma	24/1827	76/9376	1.62060323221848	SHC1/CALML4/CDKN1A/PIK3R3/KRAS/BAX/MAPK3/NRAS/SOS2/PDGFB/DDB2/CAMK1D/SHC2/MTOR/HRAS/PDGFA/CALM1/POLK/AKT3/ARAF/GADD45B/BRAF/CAMK2G/CALM2	2.67232672052511
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	37/1827	130/9376	1.46062060544819	CREB5/GNAI2/GNG12/ADCY4/EDN1/MMP9/GNG5/GNG11/SHC1/PIK3R3/GNG10/KRAS/TGFBR1/CREB1/SMAD2/GNB4/MAPK3/NRAS/MAP2K4/SOS2/MAPK14/ARRB1/RELA/MAPK8/MAPK12/RXFP1/GNAI3/SHC2/HRAS/NOS3/ATF6B/AKT3/ADCY6/PRKCZ/NFKBIA/MMP1/GNAS	2.60164653816437
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	32/1827	109/9376	1.50661584891259	LY96/IFNAR2/PIK3R3/IRF7/TICAM1/MAP2K3/RAC1/MAP3K8/IFNAR1/MAPK3/MAP2K4/MAPK14/MYD88/IL6/RELA/TRAF6/MAPK8/IRF9/MAPK12/MAP3K7/CHUK/TYK2/AKT3/TOLLIP/IRAK1/MAP2K6/IKBKG/CD40/TIRAP/TLR5/JAK1/NFKBIA	2.61717425030018
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	32/1827	109/9376	1.50661584891259	NFATC1/NFATC2/TGFBR1/AHR/SMAD2/SMAD3/MAPK3/STAT5A/MAPK14/SMAD4/IFNGR1/IL6/RELA/HLA-DMA/MAPK8/IL4R/RARA/MAPK12/CHUK/MTOR/TYK2/HLA-DRB1/IL1RAP/LAT/IKBKG/HLA-DRB5/NFKBIE/RXRB/IL27RA/JAK1/NFKBIA/PPP3CA	2.61717425030018
Human Diseases	Infectious disease: viral	hsa05162	Measles	38/1827	136/9376	1.4339160951737	HSPA1B/IFNAR2/HSPA1A/PIK3R3/IRF7/MSN/IFIH1/EIF2S1/BAX/OAS2/IFNAR1/CSNK2B/TNFAIP3/CYCS/ADAR/STAT5A/EIF2AK2/MX1/BCL2L1/MYD88/IL6/CCND3/RELA/TRAF6/MAPK8/IRF9/MAP3K7/CHUK/TYK2/AKT3/OAS3/IRAK1/IKBKG/CDK2/OAS1/JAK1/NFKBIA/BBC3	2.50754899469578
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	41/1827	150/9376	1.40272213099799	LEF1/SHC1/CDKN1A/PIK3R3/KRAS/TGFBR1/FZD6/SMAD2/SMAD3/BAX/JUP/MAPK3/NRAS/SOS2/SMAD4/AXIN2/MYC/DDB2/ABCB1/CTNNA1/LRP6/LRP5/SHC2/MTOR/HRAS/MET/POLK/AKT3/ARAF/FZD4/WNT2B/TCF7L1/WNT6/AXIN1/CDK2/GADD45B/TGFB2/RXRB/BRAF/TGFB3/RPS6KB2	2.44598956457009
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	33/1827	116/9376	1.45993998074854	CDH5/CLDN5/ICAM1/GNAI2/MMP9/ESAM/AFDN/PIK3R3/MSN/PECAM1/F11R/RAPGEF4/PXN/RAC1/BCAR1/JAM2/MYL12A/MAPK14/VAV2/ACTN4/MAPK12/RAP1A/GNAI3/CTNNA1/CD99/JAM3/CLDN15/RAPGEF3/CLDN10/PTK2/VAV3/CLDN3/MYL12B	2.45208128772734
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	88/1827	362/9376	1.24753618981091	PRL/YWHAH/CREB5/ANGPT2/SGK1/IL3RA/KDR/EFNA1/IFNAR2/ITGA6/GNG12/GNG5/ITGA2/GNG11/FGFR1/CDKN1A/PIK3R3/GNG10/YWHAG/PPP2R1A/KRAS/CDC37/NR4A1/EPHA2/PPP2R1B/ITGA5/RAC1/LAMA5/CREB1/ITGA1/VWF/EIF4E/THBS1/PPP2R3C/PRKAA1/IFNAR1/GNB4/MAPK3/NRAS/SOS2/G6PC3/FLT4/OSMR/BCL2L1/IL6/CCND3/RELA/MYC/EIF4EBP1/ITGA3/IL4R/LPAR6/PDGFB/PHLPP1/RHEB/CHUK/PPP2R2A/MTOR/CSF1/LAMA4/HRAS/NOS3/PDGFA/MET/PDGFD/ATF6B/AKT3/ITGA8/KITLG/GHR/FLT1/PPP2R5B/IKBKG/PKN3/CDK2/PHLPP2/ITGB4/RELN/IL7/JAK1/VTN/PTK2/PGF/FN1/HSP90B1/ITGA9/RPS6KB2/LAMC2	2.36289492425573
NA	NA	hsa04519	Cadherin signaling	97/1827	404/9376	1.23216656641034	CDH5/YWHAH/KDR/ARPC5L/LEF1/MYO1D/ATN1/FGFR1/APH1A/AFDN/YWHAG/MOB1A/NCKAP1/KRAS/MAP2K3/DSP/KRT10/FZD6/PPP1CA/KRT18/PPP1CC/AMOTL2/RAC1/RYK/MPDZ/MYO1B/TEAD4/GJA1/LHFPL6/JUP/NCSTN/PCDH11X/EVL/MAPK3/NRAS/ARPC1A/TEAD2/TAOK2/MAPK14/FLT4/ARPC3/AXIN2/VAV2/RELA/ACTN4/DCHS1/BRK1/MAPK8/TMC6/MAPK12/PCDH17/SHOC2/KRT23/AMOTL1/CTNNA1/ACTR2/CHUK/PCDH1/PCDH12/LRP6/LRP5/MRAS/PPP1CB/PCDH7/HRAS/KRT8/WTIP/MET/CDH2/CDH12/ARPC1B/ABI2/PCDHB10/WWTR1/FZD4/WNT2B/TMC7/TCF7L1/ACTR3/FAT4/PCDH20/WNT6/CDH26/VANGL1/IKBKG/ANKRD6/AXIN1/ERBIN/WASF1/CELSR1/NFKBIA/MYO1E/PTK2/PCDHB2/VAV3/SCN3B/CDH24	2.34669110835411
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	23/1827	75/9376	1.57378580550994	IGFBP3/SHISA5/EI24/CDKN1A/PMAIP1/SERPINE1/SIVA1/SIAH1/BAX/THBS1/CYCS/CCNG1/BCL2L1/CCND3/TNFRSF10B/ZMAT3/DDB2/TNFRSF10A/SESN3/RRM2B/CDK2/GADD45B/BBC3	2.45428961107508
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	8/1827	18/9376	2.28084899349267	CD320/LMBRD1/PRDX1/THAP11/HCFC1/TCN2/ZNF76/MMAB	2.67579515264117
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	49/1827	187/9376	1.34472514188539	CCL2/GABARAPL2/IFNAR2/CXCL2/NOD1/IRF7/TICAM1/GSDMD/CXCL3/BIRC2/CARD16/OAS2/CARD6/IFNAR1/TNFAIP3/MAPK3/RBCK1/VDAC3/CARD8/RIPK2/MAPK14/BCL2L1/MYD88/IL6/RELA/TRAF6/MAPK8/IRF9/MAPK12/MAP3K7/DHX33/TRPV2/CHUK/PYCARD/GABARAP/CASP1/GBP4/TYK2/NLRP1/GPSM3/OAS3/CXCL1/NEK7/IKBKG/ERBIN/OAS1/JAK1/NFKBIA/CAMP	2.3424473363209
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	53/1827	205/9376	1.32678654865366	SCIN/YWHAH/CREB5/GTF2A2/HLA-C/CDKN1A/PMAIP1/HLA-F/PIK3R3/YWHAG/IRF7/RASA2/EGR3/KRAS/RANBP1/HLA-A/PXN/RAC1/CREB1/HLA-E/BAX/HDAC7/MAPK3/TBPL1/NRAS/STAT5A/VDAC3/EIF2AK2/CCND3/RELA/HDAC1/ACTN4/HDAC2/UBR4/IRF9/GTF2E2/SP100/PKM/DLG1/HRAS/ATF6B/GTF2H3/KAT2A/IKBKG/TBP/CDK2/JAK1/NFKBIA/HDAC6/HLA-B/EGR2/GTF2H4/HDAC9	2.32724954776847
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	34/1827	122/9376	1.43020449182122	NFATC1/NFATC2/BCL10/PIK3R3/PPP2R1A/KRAS/PPP2R1B/PPP2R3C/MAP3K8/MAPK3/NRAS/SOS2/MAPK14/VAV2/RELA/MAPK8/MAPK12/MAP3K7/MALT1/CHUK/PPP2R2A/DLG1/HRAS/PAK4/NCK2/AKT3/MAP3K14/PPP2R5B/LAT/IKBKG/NFKBIE/NFKBIA/VAV3/PPP3CA	2.35288286813518
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	12/1827	33/9376	1.866149176494	STX3/VAMP2/STX6/SNAP23/VAMP5/GOSR2/VAMP7/VAMP4/STX7/BET1L/YKT6/BNIP1	2.45197869044134
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	30/1827	106/9376	1.45242742510147	CREB5/LEF1/FOLH1/MMP9/FGFR1/CDKN1A/PIK3R3/ERG/KRAS/CREB1/MAPK3/NRAS/SOS2/RELA/PDGFB/CHUK/MTOR/HRAS/PDGFA/PDGFD/AKT3/ARAF/TCF7L1/IKBKG/CDK2/BRAF/NFKBIA/GRM5/ETV5/HSP90B1	2.30447599049503
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	37/1827	137/9376	1.38599035553478	IL3RA/PMAIP1/PIK3R3/KRAS/CTSD/TNFRSF1A/LMNA/BIRC2/EIF2S1/BAX/CFLAR/TNFSF10/CYCS/MAPK3/DAB2IP/NRAS/BCL2L1/RELA/TNFRSF10B/MAPK8/TUBA1A/TNFRSF10A/CTSO/SPTAN1/CHUK/HRAS/CTSF/CASP2/TUBA4A/AKT3/CTSL/MAP3K14/IKBKG/GADD45B/NFKBIA/BBC3/CSF2RB	2.2388987435369
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	26/1827	90/9376	1.48255184577024	CREB5/ADCY4/PIK3R3/KRAS/ADIPOR1/CREB1/EIF4E/BAX/PRKAA1/NRAS/ADIPOR2/RELA/EIF4EBP1/ATG101/RHEB/MTOR/SESN3/HRAS/PRKAG2/PRKAG1/ATF6B/AKT3/ADCY6/KL/PRKAB2/RPS6KB2	2.2628777665872
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	23/1827	78/9376	1.5132555822211	LSM8/LSM5/LSM3/LSM2/LSM6/CNOT7/DCP1A/CNOT8/C1D/DHX36/BTG2/TENT4B/DIS3/PATL1/XRN2/PAN3/PFKL/EXOSC10/DCPS/NUDT16/EXOSC9/EDC4/BTG1	2.23921817816583
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	23/1827	78/9376	1.5132555822211	LY96/GNAI2/CALML4/NOD1/TICAM1/ITGA5/SERPING1/MAPK3/MAPK14/MYD88/IL6/RELA/TRAF6/MAPK8/MAPK12/GNAI3/PYCARD/CALM1/CASP1/IRAK1/TIRAP/CFL1/CALM2	2.23921817816583
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	39/1827	148/9376	1.35232769715528	LEF1/JAG1/JAG2/SHC1/FGFR1/CDKN1A/PIK3R3/KRAS/NOTCH4/FZD6/NOTCH1/BAX/MAPK3/NRAS/SOS2/FLT4/AXIN2/MYC/SP1/DDB2/LRP6/LRP5/SHC2/MTOR/HRAS/POLK/AKT3/ARAF/FZD4/WNT2B/TCF7L1/WNT6/AXIN1/DLL1/GADD45B/BRAF/DLL4/HEY1/RPS6KB2	2.12536756810629
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	41/1827	157/9376	1.34018037993439	S1PR1/DUSP5/SGK1/NFATC1/NFATC2/PROS1/SCARF1/PECAM1/UQCRFS1/ATP11A/ATP11B/RAC1/CREB1/BCAR1/LIPA/NR1H2/THBS1/CRK/MAPK3/ARG2/DUSP8/MAPK14/ODC1/RAB14/ATP11C/ANO6/MAPK12/CPT1A/XKR8/DOCK1/CASP1/TGFBRAP1/DUSP7/ANO5/CAMK2G/PTK2/TYRO3/CX3CL1/SPHK1/STAB2/DUSP4	2.11459587053502
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	33/1827	122/9376	1.38813965382648	IGFBP3/CREB5/GNAI2/ADCY4/SHC1/PIK3R3/KRAS/MAP2K3/CREB1/BCAR1/CRK/MAPK3/NRAS/MAP2K4/STAT5A/SOS2/MAPK14/MAPK8/MAP3K1/MAPK12/SOCS3/GNAI3/SHC2/MTOR/HRAS/ATF6B/AKT3/JUNB/MAP2K6/GHR/ADCY6/GNAS/PTK2	2.1228210288231
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	29/1827	105/9376	1.41738473167045	LY96/ICAM1/CXCL2/BCL10/TICAM1/TNFRSF1A/CXCL3/BIRC2/CFLAR/CSNK2B/TNFAIP3/BCL2L1/MYD88/RELA/TRAF6/MAP3K7/CARD10/MALT1/CHUK/CCL21/CXCL1/IRAK1/MAP3K14/LAT/IKBKG/CD40/TIRAP/GADD45B/NFKBIA	2.1158170684905
NA	NA	hsa04518	Integrin signaling	40/1827	154/9376	1.33296369749572	ICAM1/ICAM2/KDR/ITGA6/ITGA2/PIK3R3/LIMS2/PXN/ITGA5/RAC1/LAMA5/ITGA1/PARVB/VWF/THBS1/FLNB/ITGAE/FLT4/CCND3/ACTN4/ITGA3/PDGFB/MTOR/LAMA4/PDGFA/MET/PDGFD/NCK2/AKT3/ITGA8/FLT1/ITGB4/RELN/VTN/PTK2/FRAS1/PGF/FN1/ITGA9/LAMC2	2.0495328628194
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	26/1827	93/9376	1.43472759268087	NFATC1/NFATC2/JAG1/JAG2/NOTCH1/MAPK3/STAT5A/MAPK14/IFNGR1/RELA/HLA-DMA/MAPK8/IL4R/MAPK12/CHUK/TYK2/HLA-DRB1/LAT/IKBKG/HLA-DRB5/NFKBIE/DLL1/JAK1/NFKBIA/DLL4/PPP3CA	2.07264395693716
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	51/1827	204/9376	1.28297755883963	KDR/HOXD10/MMP9/ITGA2/FGFR1/HBEGF/CAV2/CDKN1A/PIK3R3/KRAS/MSN/PXN/FZD6/PPP1CA/PPP1CC/ITGA5/RAC1/SMAD2/THBS1/MAPK3/NRAS/HSPG2/SOS2/CBL/MAPK14/VAV2/MYC/IQGAP1/MAPK12/HCLS1/MRAS/PPP1CB/MTOR/HRAS/MET/AKT3/ARAF/FZD4/CTSL/WNT2B/ELK1/ARHGEF12/WNT6/TGFB2/BRAF/CAMK2G/VTN/PTK2/VAV3/FN1/RPS6KB2	2.0102277117903
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	34/1827	128/9376	1.3631636562671	PNP/PDE4D/ADCY4/AK2/AK1/AK3/NUDT2/DGUOK/ENTPD1/PGM2/NT5C2/PDE9A/NME1/NME3/PDE1A/CANT1/PDE8A/ENTPD4/HPRT1/NPR1/AK6/IMPDH1/NUDT16/RRM1/PDE7B/ADCY6/GMPR2/RRM2B/PDE1C/PDE6D/HDDC3/PDE3A/PDE2A/ENPP4	2.03513701514267
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	31/1827	115/9376	1.38338449822708	JUND/CREB5/SGK1/PDE4D/GNAI2/ADCY4/FGFR1/HBEGF/CDKN1A/GNA13/CREB1/MAPK3/ARRB1/NR4A2/SP1/GNA12/PLD1/GNAI3/LRP6/LRP5/MEF2A/MEF2C/ATF6B/ARAF/MMP16/ADCY6/RXRB/BRAF/GNAS/KL/BGLAP	2.03500146352474
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	24/1827	85/9376	1.44900994880711	PNP/AK2/CDA/AK1/NT5C3A/AK3/DGUOK/UPP1/ENTPD1/NT5C2/NME1/NME3/CANT1/DCTD/ENTPD4/HPRT1/UCK2/AK6/IMPDH1/NUDT16/RRM1/CMPK2/GMPR2/RRM2B	2.04571154384532
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	50/1827	201/9376	1.27659458591008	IGFBP3/DUSP6/LMO2/MMP9/MAX/LYL1/CDKN1A/ZBTB17/ERG/KLF3/MLF1/BIRC2/SMAD1/PER2/BAX/HHEX/ELK4/JUP/FLI1/EWSR1/CDK9/BCL2L1/IL6/RELA/HDAC1/MYC/SIN3A/SP1/HDAC2/RARA/CDKN2C/KMT2A/DDB2/BMP2K/ETV6/TSPAN7/PML/MEF2C/PDGFA/MET/POLK/FLT1/ETV1/CD40/GADD45B/LDB1/RXRB/PTK2/ETV5/JMJD1C	1.9500640066252
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	14/1827	44/9376	1.63288052943225	CREB5/VAMP2/ARHGDIA/CREB1/RAB11B/DYNLL2/ARHGDIB/DYNC1LI1/DCTN6/RAB11A/ADCY6/DYNLL1/AVPR2/GNAS	2.07000267739106
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	43/1827	170/9376	1.29807141247304	MGST2/MGST3/LEF1/SHC1/CDKN1A/PIK3R3/KRAS/TGFBR1/FZD6/NQO1/SMAD2/SMAD3/SMARCD1/BAX/MAPK3/NRAS/SOS2/SMAD4/BCL2L1/AXIN2/MYC/DDB2/LRP6/LRP5/SHC2/MTOR/HRAS/MET/POLK/AKT3/ARAF/FZD4/WNT2B/ELK1/TCF7L1/WNT6/AXIN1/GADD45B/TGFB2/BRAF/TGFB3/GSTM4/RPS6KB2	1.92938767620208
Organismal Systems	Endocrine system	hsa04924	Renin secretion	20/1827	69/9376	1.48751021314739	REN/AQP1/ORAI1/GNAI2/EDN1/CALML4/CREB1/PDE1A/NPR1/GNAI3/KCNMA1/CALM1/ADCY6/ACE/PDE1C/PDE3A/GNAS/ADRB1/CALM2/PPP3CA	1.99946407774915
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	48/1827	193/9376	1.27633000672129	CCL14/CCL2/GNAI2/GNG12/ADCY4/GNG5/CXCL2/GNG11/SHC1/PIK3R3/GNG10/KRAS/PXN/CXCL3/RAC1/BCAR1/CRK/RASGRP2/GNB4/MAPK3/NRAS/SOS2/VAV2/ARRB1/RELA/CCL23/RAP1A/GNAI3/GRK5/CHUK/SHC2/CCL21/HRAS/XCL2/FGR/AKT3/CXCL1/PREX1/ADCY6/IKBKG/PRKCZ/BRAF/NFKBIA/PTK2/CCL8/CX3CL1/VAV3/XCL1	1.90820315303232
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	19/1827	65/9376	1.50009683802787	PLPP2/PLPP5/PNPLA2/DGKZ/AGPAT1/AGPAT4/DGKD/DGKH/PLPP3/AKR1B1/LCLAT1/DGAT1/GLA/ALDH2/AGPAT2/GPAT4/AGK/GLYCTK/DGKQ	1.99031961379067
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	23/1827	82/9376	1.4394382367469	HSPA1B/HLA-C/HSPA1A/HLA-F/B2M/HLA-A/CREB1/HLA-E/TAPBPL/HLA-DMA/RFXANK/CANX/NFYA/HSPA2/KLRC3/CTSL/HLA-DRB1/CD74/HLA-DRB5/TAP2/RFXAP/HLA-B/KLRC1	1.96613635993627
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	26/1827	95/9376	1.40452280125601	ICAM1/CCL2/CXCL2/ATP6V1F/ATP6V1A/CXCL3/ATP6V0B/ATP6AP1/IL6/ATP6V0C/ATP6V1E1/HLA-DMA/ATP6V1G1/ACP5/CSF1/CXCL1/CTSL/HLA-DRB1/FLT1/HLA-DRB5/TGFB2/ATP6V0A2/TGFB3/ATP6V0E1/ATP6V1B2/MMP1	1.94947478146465
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	28/1827	104/9376	1.38166814028883	LYPLA1/PLPP2/PLPP5/SGMS1/CDIPT/DGKZ/AGPAT1/AGPAT4/DGKD/CHKA/DGKH/PLPP3/PLA2G2A/PLD1/LCLAT1/LYPLA2/PISD/PTDSS1/AGPAT2/CRLS1/GPAT4/PLA1A/CHPT1/CEPT1/LPCAT4/CDS1/DGKQ/SGMS2	1.92542260449633
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	37/1827	144/9376	1.31861582436295	LY96/LEF1/NOX4/CXCL2/TICAM1/MAP2K3/TNFRSF1A/ADIPOR1/CXCL3/PRKAA1/MAP2K4/MAPK14/ADIPOR2/MYD88/IL6/RELA/TRAF6/MAPK8/MAPK12/MAP3K7/CHUK/ALDH2/CPT1A/PRKAG2/PRKAG1/AKT3/CXCL1/IRAK1/TCF7L1/MAP2K6/TRA2B/MAP3K14/IKBKG/TIRAP/ACACB/NFKBIA/PRKAB2	1.89544369912624
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	32/1827	122/9376	1.34607481583174	CREB5/LEPR/PIK3R3/PPP2R1A/ADIPOR1/PPP2R1B/CREB1/ELAVL1/PPP2R3C/PRKAA1/RAB11B/RAB8A/G6PC3/ADIPOR2/RAB14/TBC1D1/EIF4EBP1/MAP3K7/RHEB/PPP2R2A/PFKL/MTOR/CPT1A/PRKAG2/PRKAG1/AKT3/PPP2R5B/STRADA/STRADB/ACACB/PRKAB2/RPS6KB2	1.89275918951102
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	24/1827	87/9376	1.41569937527131	ATP1A1/COX7A2/COX8A/UQCRFS1/ASPH/COX5A/COX7A1/COX6B1/COX6A1/COX5B/UQCR11/UQCRQ/UQCRH/UQCR10/TPM3/COX7C/COX7B/CYC1/UQCRB/RYR2/ATP1B3/SLC9A6/MT-CO2/UQCRC1	1.91630536683488
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1827	29/9376	1.76962421908914	RASSF1/MOB1A/TEAD4/FRMD6/CSNK1E/TEAD2/DCHS1/WTIP/WWTR1/FAT4	2.04198149809887
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	15/1827	49/9376	1.57099292919138	B4GALT3/EOGT/C1GALT1C1/GALNT18/GALNT4/GALNT10/GALNT7/MFNG/FUT11/LFNG/GALNT15/POFUT2/B3GLCT/GALNT9/GALNT6	1.97136926389754
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	45/1827	181/9376	1.27588928503388	PLK3/BCL10/IL10RB/CALML4/CTSD/TNFRSF1A/ATP6V0B/CEBPG/CREB1/ATP6AP1/BAX/CYCS/MAPK3/RIPK2/MAPK14/MYD88/IFNGR1/IL6/ATP6V0C/RELA/TRAF6/HLA-DMA/MAPK8/RFXANK/MAPK12/MALT1/CALM1/NFYA/AKT3/IRAK1/HLA-DRB1/ARHGEF12/CD74/TIRAP/HLA-DRB5/TGFB2/ATP6V0A2/TGFB3/RFXAP/JAK1/CAMK2G/CALM2/SPHK1/PPP3CA/CAMP	1.8437772565808
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	18/1827	62/9376	1.4899094231686	HSPA1B/HSPA1A/ADCY4/PIK3R3/KRAS/PRKAA1/NRAS/HDAC1/HDAC2/MTOR/HRAS/PRKAG2/PRKAG1/CLPB/AKT3/ADCY6/PRKAB2/RPS6KB2	1.90394202556762
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	19/1827	67/9376	1.45531782793749	CALML4/RPS6KA2/KRAS/PPP1CA/PPP1CC/RPS6KA3/MAPK3/NRAS/RAP1A/PPP1CB/HRAS/CALM1/ARAF/RAPGEF3/BRAF/CAMK2G/GRM5/CALM2/PPP3CA	1.8399699946463
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	36/1827	142/9376	1.30104766530216	JUND/NFATC1/NFATC2/IFNAR2/FOSL1/FOSB/PIK3R3/TGFBR1/TNFRSF1A/RAC1/CREB1/IFNAR1/MAPK3/MAPK14/IFNGR1/RELA/TRAF6/MAPK8/IRF9/MAPK12/MAP3K7/FOSL2/SOCS3/CHUK/ACP5/CSF1/TYK2/AKT3/JUNB/MAP2K6/MAP3K14/IKBKG/TGFB2/JAK1/NFKBIA/PPP3CA	1.77825770764469
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	26/1827	98/9376	1.3615272052992	CREB5/ORAI1/ATP1A1/ADCY4/CALML4/PRKD3/NR4A1/LDLR/CREB1/PRKD2/NR4A2/NPR1/ATP2B1/PRKD1/PRKCE/CAMK1D/ATF6B/CALM1/ATP1B3/ADCY6/CAMK2G/GNAS/DAGLB/CALM2/POMC/PDE2A	1.76985235032168
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	25/1827	94/9376	1.36486974344641	JUND/CCL2/MMP9/CXCL2/FOSL1/FOSB/CXCL3/ELAVL1/TNFAIP3/MAPK3/MAPK14/IL6/RELA/TRAF6/MAPK8/TRAF4/MAPK12/MAP3K7/CHUK/MAPK7/CXCL1/IKBKG/NFKBIA/MMP1/HSP90B1	1.74900558084831
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	27/1827	103/9376	1.34525802286097	RBM8A/PELO/NXT1/MAGOH/PPP2R1A/PPP1CA/PPP2R1B/PPP1CC/CPSF6/PPP2R3C/UPF3A/NUDT21/PABPN1/PNN/SSU72/DAZAP1/UPF3B/SAP18/DDX19B/PPP1CB/PPP2R2A/ALYREF/SMG5/PYM1/PPP2R5B/CPSF1/CPSF3	1.73325499658646
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	15/1827	51/9376	1.50938536334074	ATP6V1F/ATP6V1A/ATP6V0B/ATP6AP1/ERO1A/SLC12A2/SEC61G/ATP6V0C/ATP6V1E1/ATP6V1G1/TJP2/ATP6V0A2/ATP6V0E1/ATP6V1B2/GNAS	1.79439201841105
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	35/1827	139/9376	1.29220761321977	CREB5/HSPA1B/GNAI2/HSPA1A/ADCY4/MMP9/SHC1/CALML4/HBEGF/PIK3R3/KRAS/CTSD/KRT10/KCNJ6/KRT18/CREB1/MAPK3/NRAS/SOS2/SP1/RARA/KRT23/GNAI3/SHC2/HRAS/NOS3/ATF6B/CALM1/AKT3/ADCY6/GPER1/GNAS/CALM2/POMC/HSP90B1	1.70743293526661
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	39/1827	158/9376	1.26673733657584	YWHAH/CDC25B/CDC26/RBX1/CDKN1A/YWHAG/ZBTB17/PPP2R1A/ANAPC16/PPP2R1B/SMAD2/SMAD3/CDC14A/E2F4/BUB3/SMAD4/CCND3/ANAPC10/HDAC1/CCNH/MYC/HDAC2/CUL1/CDKN1C/CDKN2C/MCM3/TFDP1/ESCO1/WEE1/ORC4/PPP2R5B/PCNA/CDK2/GADD45B/TGFB2/ANAPC1/TGFB3/DBF4/E2F5	1.66342874134986
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	17/1827	60/9376	1.45404123335158	KDR/NFATC2/PIK3R3/KRAS/PXN/RAC1/MAPK3/NRAS/MAPK14/MAPK12/SHC2/HRAS/NOS3/AKT3/PTK2/SPHK1/PPP3CA	1.73566689131435
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	16/1827	56/9376	1.46626006724529	HSPA1B/HSPA1A/CXCL2/CXCL3/HSF1/CYCS/MYD88/IL6/RAB1B/RELA/VCP/PYCARD/CASP1/CXCL1/TLR5/NFKBIA	1.72156917721558
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	19/1827	69/9376	1.41313470249002	FCER1A/PIK3R3/KRAS/MAP2K3/RAC1/MAPK3/NRAS/MAP2K4/SOS2/MAPK14/VAV2/MAPK8/MAPK12/INPP5D/HRAS/AKT3/MAP2K6/LAT/VAV3	1.69442193132196
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	24/1827	91/9376	1.35347083130334	NFATC1/NFATC2/IFITM1/BCL10/PIK3R3/KRAS/RAC1/MAPK3/NRAS/SOS2/VAV2/RELA/RASGRP3/INPP5D/MALT1/CHUK/HRAS/AKT3/IKBKG/NFKBIE/NFKBIA/VAV3/PPP3CA/CD79B	1.66683849818085
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	13/1827	44/9376	1.51624620590138	GTF2A2/GTF2H5/TAF11/TBPL1/CCNH/GTF2E2/TAF3/TAF6/GTF2H3/TBP/TAF5L/TAF9B/GTF2H4	1.68851936299491
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/1827	70/9376	1.39294706388302	ICAM1/HLA-C/HLA-F/ABL2/HLA-A/RAC1/HLA-E/CYCS/HLA-DMA/SNTB2/EIF4G2/DAG1/SGCE/HLA-DRB1/CD40/HLA-DRB5/HLA-B/CXADR/SNTB1	1.62334842188165
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	11/1827	36/9376	1.56808368302621	ST6GALNAC3/C1GALT1C1/ST3GAL1/GALNT18/GALNT4/GALNT10/GALNT7/B4GALT5/GALNT15/GALNT9/GALNT6	1.67996535942672
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	33/1827	133/9376	1.2733311110288	ICAM1/ICAM2/NFATC1/NFATC2/IFNAR2/HLA-C/SHC1/PIK3R3/KRAS/HLA-A/RAC1/HLA-E/SH3BP2/TNFSF10/IFNAR1/MAPK3/NRAS/SOS2/IFNGR1/VAV2/TNFRSF10B/TNFRSF10A/SHC2/HRAS/ARAF/KLRC3/LAT/BRAF/ULBP2/HLA-B/KLRC1/VAV3/PPP3CA	1.56177551501484
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/1827	20/9376	1.79616858237548	LIPA/FDFT1/EBP/LBR/SQLE/MSMO1/DHCR7	1.75341665059961
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	9/1827	28/9376	1.64954257565095	PTS/PCBD1/AKR1C3/GCH1/MOCS2/ALPL/AKR1B1/FPGS/DHFR	1.69331394948541
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	9/1827	28/9376	1.64954257565095	ATP6V1F/ATP6V1A/SLC12A7/ATP6V0C/ATP6V1E1/ATP6V1G1/ATP6V0A2/ATP6V0E1/ATP6V1B2	1.69331394948541
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	24/1827	93/9376	1.32436393170542	ADCY4/CALML4/HBEGF/KRAS/MAP2K3/MAPK3/NRAS/MAP2K4/SOS2/MAP3K3/MAPK14/MAPK8/PLD1/MAP3K1/MAPK12/HRAS/MAPK7/CALM1/ELK1/MAP2K6/ADCY6/CAMK2G/GNAS/CALM2	1.54646485343095
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	36/1827	149/9376	1.23992462062353	GNAI2/NDUFB4/GNG12/ADCY4/GNG5/GNG11/NDUFC2/NDUFC1/NDUFS7/GNG10/NDUFB3/KCNJ6/NDUFB9/NDUFA12/NDUFA8/NDUFS8/NDUFS2/GNB4/NDUFS6/MAPK3/NDUFA7/NDUFA2/NDUFAB1/MAPK14/NDUFA3/NDUFB11/MAPK8/MAPK12/GNAI3/NDUFA13/NDUFB2/NDUFA4/ADCY6/MT-ND4/GRM5/DAGLB	1.45227175141493
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	25/1827	99/9376	1.29593692812084	ITGA6/EDN1/ITGA2/LMNA/ITGA5/ITGA1/PRKAA1/IL6/TPM3/SNTB2/ITGA3/EMD/PRKAG2/PRKAG1/DAG1/RYR2/ITGA8/SGCE/ACE/ITGB4/TGFB2/TGFB3/SNTB1/PRKAB2/ITGA9	1.45620721878696
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	6/1827	17/9376	1.81126243600889	SCP2/CYP46A1/HSD3B7/CYP39A1/SLC27A5/AMACR	1.6469533710464
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/1827	17/9376	1.81126243600889	PCDH11X/MYH10/PCDH1/PCDH7/DAG1/PCDH20	1.6469533710464
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	16/1827	59/9376	1.3917044706057	CDA/NT5C3A/NUDT2/UPP1/ENTPD1/NT5C2/NME1/NME3/CANT1/DCTD/ENTPD4/UCK2/RRM1/CMPK2/RRM2B/UMPS	1.48476145833197
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	42/1827	178/9376	1.21090016789358	NFATC1/NFATC2/LEF1/SOX17/FOSL1/RBX1/CACYBP/FZD6/RAC1/RYK/SIAH1/SMAD3/CSNK1E/CSNK2B/RUVBL1/SMAD4/AXIN2/CCND3/MYC/MAPK8/CUL1/MAP3K7/NLK/LRP6/LRP5/CCAR2/FZD4/WNT2B/TCF7L1/LGR4/WNT6/VANGL1/ANKRD6/AXIN1/CCDC88C/CTBP2/CELSR1/CAMK2G/FRZB/NKD1/PPP3CA/BAMBI	1.39749551636774
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	22/1827	86/9376	1.3128142462545	LEF1/ITGA6/ITGA2/DSP/LMNA/ITGA5/ITGA1/GJA1/JUP/SNTB2/ITGA3/CTNNA1/EMD/CDH2/DAG1/RYR2/ITGA8/SGCE/TCF7L1/ITGB4/SNTB1/ITGA9	1.4336333372741
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	40/1827	169/9376	1.21465331014403	GABARAPL2/PIK3R3/KRAS/CTSD/RRAGA/EIF2S1/CFLAR/PRKAA1/PLEKHM1/MAPK3/NRAS/ATG2B/RAB8A/SH3GLB1/BCL2L1/TRAF6/MAPK8/RAB33B/MAP3K7/RPS27A/ATG101/DAPK3/RHEB/MRAS/MTOR/HRAS/RRAGB/STX7/VMP1/GABARAP/UVRAG/AKT3/CTSL/PIK3R4/C9orf72/UBA52/YKT6/ATG4D/ATG9A/RPS6KB2	1.38526247531735
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1827	34/9376	1.50938536334074	POLR2J/POLR3GL/POLR2K/POLR2I/POLR2F/POLR2G/POLR2E/POLR3K/POLR2L/POLR3B	1.46378127759867
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	32/1827	133/9376	1.23474531978551	CREB5/GNAI2/GNG12/GNG5/GNG11/CALML4/GNG10/MAOA/PPP2R1A/KCNJ6/PPP1CA/COMT/PPP2R1B/PPP1CC/CREB1/PPP2R3C/GNB4/MAPK14/ARRB1/MAPK8/MAPK12/GNAI3/PPP1CB/PPP2R2A/ATF6B/CALM1/AKT3/PPP2R5B/CAMK2G/GNAS/CALM2/PPP3CA	1.34130173226676
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1827	10/9376	2.0527640941434	ETHE1/SQOR/SELENBP1/SUOX	1.6385669347597
NA	NA	hsa03272	Virion - Hepatitis viruses	13/1827	48/9376	1.3898923554096	CLDN5/CHMP1B/EPCAM/CD9/LDLR/PDCD6IP/HSPG2/TGOLN2/CHMP1A/CLDN15/CHMP7/CLDN10/CLDN3	1.33223631956213
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1827	31/9376	1.4899094231686	MDH2/CS/DLD/ACO2/PGP/SHMT2/GLYCTK/ACSS2/GLDC	1.34405545000684
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	10/1827	36/9376	1.42553062093292	POLE4/RNASEH2C/SSBP1/RPA3/MCM3/RFC2/PCNA/RFC3/RPA1/POLE	1.25840034470708
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1827	15/9376	1.7106367451195	ST6GALNAC3/ST3GAL1/HEXB/ST8SIA1/B3GALT4	1.3550095810096
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1827	59/9376	1.30472294119284	MGST2/GGT5/MGST3/TXNDC12/GGCT/SRM/ODC1/GCLM/GPX7/PGD/RRM1/LANCL1/GCLC/RRM2B/GSTM4	1.15505671368283
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	13/1827	50/9376	1.33429666119321	ICAM1/CCL2/SELE/ACKR1/PECAM1/THBS1/MYD88/IL6/MET/KLRB1/CD40/TGFB2/TGFB3	1.16594894789796
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	26/1827	110/9376	1.2129969647211	GNAI2/CDC25B/ADCY4/CDC26/PIK3R3/RPS6KA2/KRAS/ANAPC16/RPS6KA3/STK10/SPDYE2/MAPK3/MAPK14/ANAPC10/MAPK8/MAPK12/GNAI3/CPEB3/AKT3/ARAF/ADCY6/KIF22/CDK2/BRAF/ANAPC1/SPDYA	1.10543652083
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	8/1827	28/9376	1.46626006724529	ELOVL1/HACD3/ACOT7/HSD17B12/HACD2/PPT1/TECR/PPT2	1.21550873730366
Human Diseases	Cancer: specific types	hsa05218	Melanoma	18/1827	73/9376	1.26540252378703	FGFR1/CDKN1A/PIK3R3/KRAS/BAX/MAPK3/NRAS/PDGFB/DDB2/HRAS/PDGFA/MET/PDGFD/POLK/AKT3/ARAF/GADD45B/BRAF	1.11986369943696
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	18/1827	73/9376	1.26540252378703	RASSF1/CDKN1A/PIK3R3/KRAS/BAX/MAPK3/NRAS/STAT5A/SOS2/DDB2/HRAS/MET/POLK/AKT3/ARAF/GADD45B/RXRB/BRAF	1.11986369943696
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/1827	46/9376	1.33875919183266	ADRM1/PSMD7/PSMF1/PSMC6/PSMB2/PSMB6/PSMA4/PSMD6/POMP/PSMA2/PSME4/PSMA7	1.13302470955086
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1827	24/9376	1.49680715197957	EXT2/GLCE/EXTL3/HS3ST1/NDST1/EXTL2/EXT1	1.19881290731387
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	33/1827	144/9376	1.17606276226966	ID3/ID1/SMAD9/KLF4/SKIL/PCGF2/FGFR1/PIK3R3/KRAS/FZD6/SMAD2/SMAD3/SMAD1/SMAD5/MAPK3/NRAS/MAPK14/SMAD4/AXIN2/MYC/ACVR1/MAPK12/KAT6A/HRAS/AKT3/FZD4/WNT2B/LIFR/WNT6/ACVR2B/AXIN1/JAK1/PCGF1	1.04739635597833
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	33/1827	144/9376	1.17606276226966	ADRM1/PIK3R3/SLC25A5/PSMD7/ATXN3/CYCS/TBPL1/ATXN2L/OPA1/PSMC6/ATG2B/VDAC3/PSMB2/PSMB6/PSMA4/AFG3L2/MAPK8/SP1/PSMD6/ATG101/CIC/MTOR/NFYA/PUM2/AKT3/PSMA2/ATXN1L/PIK3R4/PUM1/TBP/PSMA7/KAT5/RELN	1.04739635597833
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/1827	69/9376	1.26438368117529	CREB5/FOSB/CALML4/MAOA/PPP1CA/PPP1CC/CREB1/HDAC1/HDAC2/PPP1CB/ATF6B/CALM1/CAMK2G/GNAS/CALM2/ARC/PPP3CA	1.08433763846757
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	20/1827	83/9376	1.23660487599	POLR3GL/POLR2K/IRF7/GSDMD/POLR2F/PCBP1/ADAR/POLR2E/IL6/RELA/MLKL/IL33/CHUK/POLR3K/PYCARD/CASP1/IKBKG/POLR2L/NFKBIA/POLR3B	1.06511123859064
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	35/1827	154/9376	1.16634323530875	PTS/AK2/AK1/AK3/RFK/NQO1/MTHFD2L/GCH1/MOCS2/NME1/NME3/ALPL/GCLM/TPK1/PANK3/DLD/ALDH2/AK6/COX10/NADSYN1/UROD/ALAS1/SHMT2/CMPK2/GCLC/FPGS/LIAS/MMAB/PNPO/DHFR/OXSM/PPOX/UMPS/RDH13/PSAT1	1.02391320686657
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	35/1827	155/9376	1.15881844024224	TUBB6/HLA-C/ITGA2/HLA-F/ATP6V1F/ATP6V1A/HLA-A/ITGA5/RAC1/ATP6V0B/ATP6AP1/HLA-E/TUBB2A/THBS1/SEC61G/ATP6V0C/ATP6V1E1/HLA-DMA/ATP6V1G1/STX12/TUBA1A/DYNC1LI1/STX7/CANX/TUBA4A/CTSL/HLA-DRB1/RILP/HLA-DRB5/HGS/ATP6V0A2/TAP2/ATP6V0E1/ATP6V1B2/HLA-B	0.980816952833366
Organismal Systems	Digestive system	hsa04978	Mineral absorption	15/1827	61/9376	1.26194513984226	ATP1A1/SLC30A1/MT1X/MT2A/ATOX1/HMOX2/SLC31A1/SLC39A4/ATP2B1/HEPH/ATP1B3/TRPM6/MT1M/ATP7A/ATP7B	1.00970389595309
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	21/1827	89/9376	1.21090016789358	TUBB6/GNAI2/ADCY4/KRAS/GJA1/TUBB2A/MAPK3/NRAS/SOS2/PDGFB/TUBA1A/GNAI3/HRAS/PDGFA/MAPK7/PDGFD/TUBA4A/ADCY6/GRM5/GNAS/ADRB1	0.983432157316929
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	17/1827	71/9376	1.22876723945204	PRL/SHC1/PIK3R3/KRAS/MAPK3/NRAS/STAT5A/SOS2/MAPK14/RELA/MAPK8/MAPK12/SOCS3/SOCS4/SHC2/HRAS/AKT3	0.951864250928715
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1827	30/9376	1.3685093960956	PIGK/PIGF/PIGC/PIGS/PIGX/PIGH/PGAP2/B3GALT4	0.994503930743001
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1827	30/9376	1.3685093960956	ABCG2/IL6/RELA/CHUK/SHMT2/FPGS/IKBKG/DHFR	0.994503930743001
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	17/1827	72/9376	1.21170102779298	ISG15/IRF7/IFIH1/ADAR/MAPK14/RELA/SIKE1/TRAF6/MAPK8/ZNFX1/MAP3K1/MAPK12/MAP3K7/CHUK/TBKBP1/IKBKG/NFKBIA	0.887083626059389
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	7/1827	26/9376	1.38166814028883	APOA1/FOLH1/LMBRD1/CUBN/TCN2/SLC52A3/SLC5A6	0.958687305128655
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	34/1827	154/9376	1.13301914287136	CREB5/GNAI2/ATP1A1/ADCY4/CALML4/RPS6KA5/PPP2R1A/RAPGEF4/PPP1CA/PPP2R1B/PPP1CC/CREB1/PPP2R3C/MAPK3/CREM/MAPK14/TPM3/MAPK12/ATP2B1/GNAI3/PPP1CB/PPP2R2A/ATF6B/CALM1/RYR2/AKT3/ATP1B3/PPP2R5B/ADCY6/RAPGEF3/CAMK2G/GNAS/ADRB1/CALM2	0.818789275675999
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	23/1827	101/9376	1.16865282587372	LEF1/GNAI2/ADCY4/EDN1/CALML4/KRAS/FZD6/CREB1/MAPK3/NRAS/GNAI3/HRAS/CALM1/KITLG/FZD4/WNT2B/TCF7L1/WNT6/ADCY6/CAMK2G/GNAS/CALM2/POMC	0.838315602830015
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	12/1827	49/9376	1.2567943433531	CREB5/GNAI2/FOSB/MAOA/CREB1/RELA/GNAI3/ATF6B/CDK5/GPSM1/GNAS/GRM2	0.886589745246015
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	17/1827	73/9376	1.19510238357664	TRIM5/BST2/MDFIC/SUPT4H1/SERINC3/FURIN/CPSF6/PDCD6IP/MX1/CDK9/MAP1S/BICD1/SERINC5/BICD2/PPIA/KAT2A/HGS	0.823232853717804
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	34/1827	155/9376	1.12570934194961	CREB5/ORAI1/LEF1/GNAI2/ADCY4/CDKN1A/NR4A1/AHR/LDLR/FZD6/CREB1/NCEH1/MAPK3/PDE8A/AXIN2/SP1/CDKN2C/KMT2A/RAP1A/GNAI3/ARMC5/ATF6B/KMT2D/FZD4/WNT2B/TCF7L1/WNT6/ADCY6/AXIN1/CDK2/BRAF/CAMK2G/GNAS/POMC	0.776344696029239
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	22/1827	97/9376	1.16393840389574	GNAI2/PER1/GNG12/ADCY4/GNG5/GNG11/CALML4/GNG10/RPS6KA5/KCNJ6/PER3/CREB1/PER2/GNB4/MAPK3/GNAI3/CALM1/RYR2/ADCY6/CAMK2G/GNAS/CALM2	0.798410392751737
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/1827	78/9376	1.18428697739043	MARCKSL1/MAPK3/MAPK14/MYD88/IFNGR1/RELA/TRAF6/HLA-DMA/MAPK12/MAP3K7/IRAK1/ELK1/HLA-DRB1/HLA-DRB5/TGFB2/TGFB3/JAK1/NFKBIA	0.804002458163448
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	36/1827	166/9376	1.112944388391	CREB5/NFATC1/NFATC2/GNAI2/ATP1A1/ADCY4/CALML4/GNA13/SLC25A5/PPP1CA/PPP1CC/CREB1/MYLK/MAPK3/VDAC3/GNA12/NPR1/ATP2B1/GNAI3/PRKCE/MEF2A/PPP1CB/KCNMA1/NOS3/MEF2C/ATF6B/CALM1/AKT3/ATP1B3/ADCY6/KCNMB3/PDE3A/ADRB1/CALM2/PPP3CA/PDE2A	0.722269184432244
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1827	27/9376	1.33049524620406	ELOVL1/HACD3/ACOT7/HSD17B12/SCP2/HACD2/TECR	0.84600848426203
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	18/1827	79/9376	1.16929600299308	STX3/VAMP2/ATP6V1F/ATP6V1A/ATP6V0B/CPLX1/UNC13B/CLTB/DNM3/ATP6V0C/ATP6V1E1/ATP6V1G1/AP2S1/SLC1A1/ATP6V0A2/ATP6V0E1/ATP6V1B2/SLC1A2	0.743359736332781
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/1827	89/9376	1.15323825513674	ITGA6/ITGA2/ITGA5/LAMA5/ITGA1/VWF/THBS1/HSPG2/ITGA3/LAMA4/DAG1/ITGA8/AGRN/ITGB4/RELN/VTN/FRAS1/FN1/ITGA9/LAMC2	0.714553380102818
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/1827	32/9376	1.28297755883963	GABARAPL2/ATG2B/ATG101/MTOR/GABARAP/PIK3R4/ATG4D/ATG9A	0.788807024081106
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/1827	32/9376	1.28297755883963	PMAIP1/TNFRSF1A/BIRC2/BAX/CYCS/BCL2L1/MAPK8/BBC3	0.788807024081106
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	30/1827	138/9376	1.11563265986055	YWHAH/ADCY4/CDC26/CALML4/RBX1/YWHAG/RPS6KA2/PPP2R1A/ANAPC16/PPP1CA/PPP2R1B/PPP1CC/RPS6KA3/SPDYE2/MAPK3/MAPK14/ANAPC10/CUL1/MAPK12/CPEB3/PPP1CB/CALM1/PPP2R5B/ADCY6/CDK2/ANAPC1/SPDYA/CAMK2G/CALM2/PPP3CA	0.673195616059168
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1827	23/9376	1.33875919183266	SSBP1/RPA3/RFC2/PCNA/RFC3/RPA1	0.800183769507778
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1827	23/9376	1.33875919183266	REN/PRCP/LNPEP/MME/ACE/THOP1	0.800183769507778
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1827	42/9376	1.22188338937107	SLC3A2/SLC39A8/PCBP2/PCBP1/ACSL5/VDAC3/GCLM/ACSL3/SLC7A11/GCLC	0.708966537519662
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/1827	28/9376	1.28297755883963	B3GNT5/B3GNT2/B4GALT3/A4GALT/ST8SIA1/B3GALNT1/FUT1	0.737703525121909
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	22/1827	100/9376	1.12902025177887	CCL14/ACKR3/CCL2/CXCL2/IL10RB/TNFRSF1A/CXCL3/TNFSF10/TNFRSF1B/TNFRSF10D/IL6/CCL23/TNFRSF10B/TNFRSF10A/CCL21/CSF1/XCL2/CXCL1/IL18R1/CCL8/CX3CL1/XCL1	0.63809848613786
Genetic Information Processing	Transcription	hsa03040	Spliceosome	51/1827	243/9376	1.07706758026043	RBM8A/HSPA1B/HSPA1A/SNRPA1/LSM8/LSM5/MAGOH/SNU13/LSM3/SF1/TXNL4A/LSM2/ISY1/LSM6/SNRPB/PCBP1/CCDC12/RBM22/SF3B6/SNRPD3/PRPF38A/SNRPF/PRPF38B/RBM17/RP9/SYF2/SNRPE/SRSF9/TCERG1/SRSF2/SRSF8/SRSF10/SF3A1/PRPF18/PUF60/SF3A3/THOC1/ALYREF/PRPF19/SF3B4/U2AF2/U2AF1/U2SURP/SRSF5/CRNKL1/RBMXL1/TRA2B/HNRNPM/SRSF4/YJU2/BUD13	0.598795227863038
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	33/1827	154/9376	1.09969505043397	NFATC1/NFATC2/GNAI2/ADCY4/CALML4/CDKN1A/KRAS/KCNJ6/PPP1CA/PPP1CC/MYLK/PRKAA1/MAPK3/NRAS/NPR1/GNAI3/CAMK1D/PPP1CB/HRAS/NOS3/MEF2C/PRKAG2/MAPK7/PRKAG1/CALM1/RYR2/ELK1/ADCY6/CAMK2G/GNAS/CALM2/PRKAB2/PPP3CA	0.613665344485432
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	16/1827	71/9376	1.15648681360192	FGFR1/PIK3R3/KRAS/MAPK3/NRAS/MYC/PKM/PDHB/PFKL/MTOR/HRAS/MET/AKT3/TIGAR/SIRT6/SIRT3	0.651116846827363
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	24/1827	110/9376	1.1196895058964	ANGPT2/EDN1/RBX1/CDKN1A/PIK3R3/SERPINE1/EGLN2/EIF4E/MAPK3/IFNGR1/IL6/RELA/MKNK2/EIF4EBP1/PDHB/PFKL/MTOR/NOS3/EPAS1/AKT3/FLT1/CAMK2G/GAPDH/RPS6KB2	0.621178574780286
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1827	19/9376	1.3505026935154	PDHB/DLD/LIAS/BCKDHA/GLDC	0.752332883482878
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	13/1827	57/9376	1.17043566771334	ELOVL1/HACD3/ACSL5/HSD17B12/SCP2/HACD2/PPT1/ACSL3/TECR/CPT1A/PPT2/OXSM/ACADSB	0.634926505688304
Human Diseases	Substance dependence	hsa05032	Morphine addiction	20/1827	91/9376	1.12789235941945	PDE4D/GNAI2/GNG12/ADCY4/GNG5/GNG11/GNG10/KCNJ6/GNB4/PDE1A/PDE8A/ARRB1/GNAI3/GRK5/PDE7B/ADCY6/PDE1C/PDE3A/GNAS/PDE2A	0.603093351486708
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	34/1827	160/9376	1.09053092501368	CDH5/CLDN5/ICAM1/ICAM2/ITGA6/HLA-C/ESAM/HLA-F/SELE/CD34/PECAM1/CD58/F11R/HLA-A/JAM2/HLA-E/HLA-DMA/CD99/CDH2/JAM3/PVR/ITGA8/CLDN15/HLA-DRB1/NRXN3/NECTIN3/CD40/HLA-DRB5/CLDN10/HLA-B/CADM3/CXADR/CLDN3/ITGA9	0.568193047525294
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1827	15/9376	1.3685093960956	AK2/AK1/ALPL/TPK1	0.702656829710705
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	14/1827	63/9376	1.14042449674634	LEF1/CDKN1A/FZD6/BAX/AXIN2/DDB2/POLK/BMP2/FZD4/WNT2B/TCF7L1/WNT6/AXIN1/GADD45B	0.55014674602637
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/1827	39/9376	1.18428697739043	HLA-C/HLA-F/HLA-A/HLA-E/HLA-DMA/HLA-DRB1/CD40/HLA-DRB5/HLA-B	0.567327022766377
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/1827	44/9376	1.16634323530875	HLA-C/ICA1/HLA-F/HLA-A/HLA-E/PTPRN2/HLA-DMA/HLA-DRB1/HLA-DRB5/HLA-B	0.544069419806456
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	21/1827	98/9376	1.09969505043397	SYNJ2/CALML4/PIK3R3/CDIPT/DGKZ/DGKD/ITPKC/MTMR6/DGKH/INPP1/PIK3C2A/INPP5A/INPP5D/IPPK/PIK3C2B/INPP5F/CALM1/ITPKB/CDS1/CALM2/DGKQ	0.488055993407106
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	35/1827	168/9376	1.06914796569969	PRL/IL3RA/LEPR/IFNAR2/IL10RB/CDKN1A/PIK3R3/IL13RA1/IFNAR1/STAT5A/SOS2/OSMR/BCL2L1/IFNGR1/IL6/CCND3/MYC/IL4R/PDGFB/PIAS3/IRF9/SOCS3/SOCS4/PTPN2/MTOR/HRAS/PDGFA/TYK2/AKT3/LIFR/GHR/IL27RA/IL7/JAK1/CSF2RB	0.44489916703485
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/1827	45/9376	1.14042449674634	HLA-C/HLA-F/HLA-A/HLA-E/IL6/HLA-DMA/HLA-DRB1/HLA-DRB5/HLA-B/KLRC1	0.464510181336192
Organismal Systems	Nervous system	hsa04730	Long-term depression	13/1827	60/9376	1.11191388432768	GNAI2/PPP2R1A/KRAS/GNA13/PPP2R1B/MAPK3/NRAS/GNA12/GNAI3/HRAS/ARAF/BRAF/GNAS	0.427814060569084
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1827	75/9376	1.09480751687648	MGST2/MGST3/CDKN1A/PMAIP1/PIK3R3/BIRC2/BAX/CYCS/MAPK3/BCL2L1/SLC31A1/AKT3/ATP7A/ATP7B/BBC3/GSTM4	0.405526071728074
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	22/1827	105/9376	1.07525738264655	ITGA6/ADCY4/ITGA2/LMNA/ITGA5/ITGA1/TPM3/SNTB2/ITGA3/EMD/DAG1/RYR2/ITGA8/SGCE/ADCY6/ITGB4/TGFB2/TGFB3/GNAS/ADRB1/SNTB1/ITGA9	0.381496596907634
Organismal Systems	Immune system	hsa04611	Platelet activation	26/1827	126/9376	1.0589656041216	ORAI1/GNAI2/ADCY4/ITGA2/PIK3R3/GNA13/PPP1CA/PPP1CC/SNAP23/VWF/MYL12A/MYLK/RASGRP2/MAPK3/MAPK14/MAPK12/RAP1A/GNAI3/PPP1CB/NOS3/AKT3/ARHGEF12/ADCY6/PRKCZ/GNAS/MYL12B	0.327810875557615
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/1827	51/9376	1.10688259978321	PLPP2/PAFAH1B2/PAFAH1B3/AGPS/PLPP3/PLA2G2A/PLD1/CHPT1/ENPP2/CEPT1/LPCAT4	0.376511179473603
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/1827	66/9376	1.0885870196215	NFATC1/SMAD2/SMAD3/IFNGR1/IL6/RELA/HLA-DMA/IL4R/HLA-DRB1/IL18R1/HLA-DRB5/TLR5/TGFB2/TGFB3	0.355285445919146
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	24/1827	117/9376	1.05269953545816	TFPT/BCL7B/BAZ2A/BCL7C/SMARCD1/GATAD2A/MEAF6/RUVBL1/CDK2AP1/HDAC1/HDAC2/YY1/INO80C/CDK2AP2/PHF6/MTA1/YEATS4/BCL7A/MORF4L1/VPS72/BICRA/KAT5/MRGBP/MTA2	0.282181069379871
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	22/1827	107/9376	1.05515911381203	CREB5/CALML4/PRMT1/CREB1/PPP4C/PRKAA1/G6PC3/SIK2/PKM/PDHB/PFKL/CPT1A/PRKAG2/PRKAG1/CALM1/AKT3/ACACB/CAMK2G/GNAS/CALM2/PRKAB2/PPP3CA	0.28229483172612
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	34/1827	168/9376	1.03860088096541	CHMP1B/IFNAR2/CHMP5/TICAM1/SLC25A5/TNFRSF1A/BIRC2/BAX/CFLAR/TNFSF10/IFNAR1/TNFAIP3/RBCK1/STAT5A/VDAC3/EIF2AK2/IFNGR1/TNFRSF10B/MAPK8/MLKL/IRF9/CHMP1A/TNFRSF10A/IL33/PYCARD/CASP1/TYK2/SPATA2/PPIA/CHMP4C/CHMP7/SPATA2L/JAK1/CAMK2G	0.24835871329763
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/1827	52/9376	1.08559639594122	APOA1/NPC1/LDLR/STARD3NL/LIPA/NCEH1/VAPA/STARD3/VDAC3/CETP/APOC3	0.304485220803311
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1827	38/9376	1.08040215481232	PNP/NT5C2/NMRK1/NADSYN1/SIRT6/SIRT5/SIRT3/NNMT	0.244310847856252
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1827	38/9376	1.08040215481232	SGK1/ATP1A1/PIK3R3/KRAS/MAPK3/NEDD4L/ATP1B3/NR3C2	0.244310847856252
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1827	99/9376	1.03674954249667	ADCY4/CALML4/PIK3R3/MAP2K3/PPP1CA/PPP1CC/MAPK14/MAPK8/MAPK12/HRH1/PRKCE/TRPV2/PPP1CB/CALM1/MAP2K6/IL1RAP/ADCY6/CAMK2G/GNAS/CALM2	0.180832278724324
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1827	33/9376	1.0885870196215	CS/PDHB/DLD/ACO2/GOT2/BCKDHA/ACY1	0.2507806856561
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1827	23/9376	1.11563265986055	FDPS/IDI1/FNTA/NUS1/RCE1	0.273136138815476
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1827	18/9376	1.14042449674634	ACSL5/ACSL3/ACACB/OXSM	0.293357913083351
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1827	18/9376	1.14042449674634	AGA/HEXB/MAN2C1/GBA2	0.293357913083351
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	43/1827	217/9376	1.01692230470238	MGST2/CREB5/MGST3/JAG1/GNAI2/KLF4/ADCY4/KPNA4/PIK3R3/KPNA1/RPS6KA2/KRAS/AHR/CREB1/RPS6KA3/MAPK3/NRAS/KPNA3/STAT5A/SOS2/CCND3/ARRB1/RELA/MYC/EIF4EBP1/GNAI3/EPHX4/EPHX1/PAQR8/CHRNA7/MTOR/HRAS/ATF6B/AKT3/ADCY6/DLL1/RXRB/DLL4/GNAS/ADRB1/HSP90B1/GSTM4/RPS6KB2	0.124072504040625
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	47/1827	238/9376	1.01344445824307	ISG15/CCL2/IFNAR2/HBEGF/PIK3R3/TNFRSF1A/IFIH1/VWF/OAS2/IFNAR1/MAPK3/RPL36AL/ADAR/EIF2AK2/MX1/MAPK14/MYD88/IL6/RPL22L1/RELA/TRAF6/MAPK8/IRF9/MAPK12/MAP3K7/RPS27A/CHUK/RPL39/CASP1/TYK2/OAS3/IRAK1/RPS28/IKBKG/ACE/RPL28/OAS1/UBA52/RPL26/RPS15/JAK1/NFKBIA/MMP1/RPL36A/RPS15A/RPS23/FAU	0.10335141035356
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	12/1827	59/9376	1.04377835295427	GNAI2/ADCY4/PIK3R3/PNPLA2/NPR1/GNAI3/AKT3/ADCY6/FABP4/GNAS/ADRB1/PLIN1	0.165942479735418
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	46/1827	233/9376	1.01316682758151	ATP1A1/ITGA6/ITGA2/NID2/BGN/DSP/PDLIM5/LMNA/ITGA5/ITGA1/CSRP2/THBS1/JUP/PDLIM7/FBN2/HSPG2/DIAPH1/TPM3/ELN/FMNL3/SNTB2/ITGA3/CAPZA2/LBR/SPTBN1/SUN2/PDLIM3/SPTAN1/MYH10/EMD/NEBL/DAG1/INF2/ATP1B3/ITGA8/SGCE/TMOD2/PDLIM1/AGRN/ITGB4/DIAPH2/SNTB1/NEB/FN1/ITGA9/MYOM3	0.100120946911429
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1827	65/9376	1.0263820470717	CREB5/ORAI1/ADCY4/NR4A1/LDLR/CREB1/NCEH1/PDE8A/SP1/ATF6B/ADCY6/GNAS/POMC	0.10499707605796
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	24/1827	122/9376	1.00955611187381	ATP1A1/PIK3R3/KRAS/TBC1D4/NOTCH4/NOTCH1/MAPK3/NRAS/MED30/HDAC1/MYC/SIN3A/HDAC2/RHEB/PFKL/MTOR/HRAS/MED17/AKT3/ATP1B3/KAT2A/MED12/RXRB/RCAN2	0.0522644750143696
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1827	50/9376	1.0263820470717	MAOA/SRM/ARG2/ODC1/SMOX/ALDH2/NOS3/PYCR2/GOT2/CKMT2	0.0920144398596528
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1827	19/9376	1.08040215481232	GNS/HYAL2/HEXB/HYAL1	0.172578374110357
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1827	14/9376	1.09969505043397	B3GNT2/B4GALT3/ST3GAL1	0.183638398239487
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1827	30/9376	1.0263820470717	MDH2/SDHD/CS/PDHB/DLD/ACO2	0.071197776208257
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/1827	134/9376	0.99574377700986	RAMP2/ADCY4/EDN1/CALML4/GNA13/PPP1CA/PPP1CC/MYLK/RAMP3/MAPK3/PLA2G2A/GNA12/NPR1/ADM/PRKCE/MYH10/PPP1CB/KCNMA1/CALM1/ARAF/ARHGEF12/ADCY6/KCNMB3/BRAF/GNAS/CALM2	-0.0244120353140129
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	15/1827	78/9376	0.986905814492021	SYNJ2/CDIPT/ITPKC/MTMR6/INPP1/PIK3C2A/INPP5A/INPP5D/IPPK/PIK3C2B/INPP5F/INPP5K/ISYNA1/ITPKB/MINPP1	-0.0571269738379787
NA	NA	hsa04981	Folate transport and metabolism	6/1827	31/9376	0.993272948779067	FOLH1/SLCO2B1/ABCG2/SHMT2/FPGS/DHFR	-0.0184555132609871
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1827	47/9376	0.982706215281417	MDH2/HAGH/PKM/PDHB/DLD/ACYP1/ALDH2/ACACB/ACSS2	-0.0584698029187975
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1827	47/9376	0.982706215281417	PIK3R3/MAPK3/MAPK8/SOCS3/SOCS4/PKM/PRKCE/MTOR/PRKCZ	-0.0584698029187975
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1827	63/9376	0.977506711496859	KMT5B/SMYD2/KMT2A/DLD/SMYD3/ALDH2/PRDM2/KMT2D/KMT2E/SETMAR/TMLHE/MECOM	-0.088122868617353
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	57/1827	298/9376	0.981606991326964	PRL/TNFRSF6B/CCL14/ACKR3/CCL2/IL3RA/LEPR/ACVRL1/IFNAR2/TNFRSF21/CXCL2/IL10RB/IL1RL1/TGFBR1/TNFRSF1A/IL13RA1/CXCL3/BMP6/TNFSF10/IFNAR1/RELL1/TNFSF9/TNFRSF1B/TNFRSF10D/OSMR/IFNGR1/IL6/CCL23/TNFRSF10B/ACVR1/IL4R/TNFRSF10A/TNFSF12/TNFRSF4/IL33/CCL21/GDF15/CSF1/XCL2/BMP2/CXCL1/RELT/LIFR/GHR/IL1RAP/ACVR2B/IL18R1/CD40/TGFB2/TGFB3/IL27RA/IL7/CCL8/CX3CL1/GDF10/XCL1/CSF2RB	-0.158736213954695
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	43/1827	226/9376	0.976425398762903	CREB5/NFATC1/ORAI1/PDE4D/GNAI2/ATP1A1/ADCY4/EDN1/CALML4/AFDN/PIK3R3/RAPGEF4/PPP1CA/PPP1CC/RAC1/CREB1/MAPK3/ARAP3/VAV2/RELA/FXYD1/MAPK8/PLD1/NPR1/ATP2B1/RAP1A/GNAI3/PPP1CB/CALM1/RYR2/AKT3/ATP1B3/ADCY6/RAPGEF3/BRAF/PDE3A/NFKBIA/CAMK2G/GNAS/ADRB1/CALM2/POMC/VAV3	-0.1764811101968
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1827	53/9376	0.968284950067644	ATP1A1/CLTB/DNM3/ATP2B1/AP2S1/RAB11A/ATP1B3/ADCY6/GNAS/KL	-0.113903138638146
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1827	37/9376	0.970901936419178	APOA1/ICAM1/SELE/MYD88/IL6/LAMA4/THOP1	-0.0872418692086738
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1827	32/9376	0.962233169129721	PGM2/G6PC3/AKR1B1/GLA/PFKL/GALE	-0.105275985805796
Human Diseases	Substance dependence	hsa05034	Alcoholism	36/1827	191/9376	0.967271039125164	CREB5/GNAI2/GNG12/GNG5/GNG11/FOSB/SHC1/CALML4/GNG10/MAOA/KRAS/PPP1CA/PPP1CC/CREB1/HDAC7/GNB4/MAPK3/NRAS/SOS2/HDAC1/HDAC2/HAT1/GNAI3/SHC2/PPP1CB/HRAS/ATF6B/CALM1/ARAF/PKIA/BRAF/HDAC6/GNAS/SLC29A1/CALM2/HDAC9	-0.22481201561714
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	8/1827	43/9376	0.954773997276002	APOA1/PLPP2/AGPAT1/PLPP3/PLA2G2A/DGAT1/AGPAT2/GOT2	-0.146225124101928
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/1827	38/9376	0.945351885460778	ORAI1/RFXANK/IKBKG/CD40/TAP2/RFXAP/DCLRE1C	-0.166054345533253
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	19/1827	103/9376	0.946663053124386	CXCL2/PIK3R3/CXCL3/LAMA5/SERPINB9/ARG2/IL6/RELA/ACTN4/PRDX1/SERPINB6/LAMA4/CXCL1/TGFB2/TGFB3/GNAS/PTK2/FN1/LAMC2	-0.267760699400322
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/1827	82/9376	0.93876406744363	MGST2/MGST3/CDA/UPP1/NME1/NME3/HPRT1/UCK2/TPMT/IMPDH1/RRM1/RRM2B/CES2/UMPS/GSTM4	-0.273982060425545
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1827	83/9376	0.927453656992502	FAR1/MPV17/ACSL5/SCP2/HACL1/AGPS/PRDX1/ACSL3/PEX13/ECH1/PEX19/ABCD3/NUDT19/PEX16/AMACR	-0.326577907292166
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1827	45/9376	0.912339597397069	ABCG1/ABCG2/ABCB1/ABCD3/TAP2/ABCC10/ABCB4/ABCA6	-0.289971838621908
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/1827	56/9376	0.916412542028306	CSNK1G3/CSNK1E/MOSMO/SMURF2/ARRB1/SMURF1/CUL1/SPOPL/HHAT/CDON	-0.308629456723705
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1827	23/9376	0.892506127888437	ARG2/NOS3/GOT2/ACY1	-0.253911491876827
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1827	116/9376	0.9290527150218	GNAI2/SHANK3/GNG12/ADCY4/GNG5/GNG11/GNG10/SLC38A1/GNB4/MAPK3/SLC38A2/PLD1/GNAI3/SLC1A1/ADCY6/GRM5/SLC1A2/GNAS/GRIK4/GRM2/PPP3CA	-0.378241764560181
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/1827	100/9376	0.923743842364532	IL3RA/ITGA6/ITGA2/CD9/CD34/ITGA5/ITGA1/CD59/IL6/HLA-DMA/ITGA3/IL4R/MME/CSF1/KITLG/HLA-DRB1/HLA-DRB5/IL7	-0.377141867846287
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/1827	46/9376	0.892506127888437	HMOX2/HCCS/COX10/HEPH/UROD/ALAS1/MMAB/PPOX	-0.35952740520135
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1827	12/9376	0.855318372559752	NPC1/ASGR1	-0.246708154720052
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	7/1827	41/9376	0.876179796280722	MAOA/DLD/ALAS1/SHMT2/GLYCTK/PSAT1/GLDC	-0.390873727704021
Genetic Information Processing	Translation	hsa03010	Ribosome	40/1827	222/9376	0.924668510875407	MRPL47/MRPL42/MRPL33/MRPL52/MRPS18C/MRPS21/MRPL32/MRPL12/MRPS33/MRPS28/MRPL41/RPL36AL/MRPL17/MRPS17/MRPL50/RPL22L1/MRPL15/MRPL22/MRPL13/MRPL9/RPS27A/RPL39/MRPL46/MRPS23/MRPL48/MRPL16/RPS28/MRPL35/MRPL2/MRPS18A/MRPL10/RPL28/UBA52/RPL26/RPS15/RPL36A/RPS15A/RPS23/FAU/MRPL39	-0.558801785169111
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1827	76/9376	0.877826750785009	GNAI2/ATP1A1/ADCY4/CALML4/MYLK/GNAI3/CALM1/ATP1B3/ADCY6/CAMK2G/GNAS/CALM2/KCNJ15	-0.526079822761315
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1827	31/9376	0.827727457315889	PGM2/RBKS/PFKL/PGD/GLYCTK	-0.472625834350261
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	20/1827	115/9376	0.892506127888437	CREB5/GNAI2/GNG12/ADCY4/GNG5/GNG11/PIK3R3/GNG10/KRAS/KCNJ6/CREB1/GNB4/MAPK3/NRAS/GNAI3/CHRNA7/HRAS/AKT3/ADCY6/CAMK2G	-0.570576504993187
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	20/1827	115/9376	0.892506127888437	GNAI2/GNG12/GNG5/GNG11/GNG10/MAOA/KRAS/KCNJ6/DUSP1/GNB4/MAPK3/NRAS/APP/GNAI3/HRAS/ARAF/RAPGEF3/BRAF/KCND2/GNAS	-0.570576504993187
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/1827	54/9376	0.855318372559752	CISD1/MDH2/SRM/GCLM/AHCYL1/ENOPH1/GCLC/GOT2/PSAT1	-0.524524664976755
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1827	54/9376	0.855318372559752	CENPX/RPA3/POLK/RAD51C/ERCC4/FANCC/USP1/RPA1/TELO2	-0.524524664976755
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/1827	54/9376	0.855318372559752	HLA-C/HLA-F/HLA-A/HLA-E/HLA-DMA/HLA-DRB1/CD40/HLA-DRB5/HLA-B	-0.524524664976755
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1827	32/9376	0.801860974274767	HIBCH/DLD/BCKDHA/ACACB/ACSS2	-0.552317490749247
Human Diseases	Immune disease	hsa05310	Asthma	5/1827	32/9376	0.801860974274767	FCER1A/HLA-DMA/HLA-DRB1/CD40/HLA-DRB5	-0.552317490749247
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1827	38/9376	0.810301616109239	PGM2/HEXB/GNPNAT1/GALE/GNPDA2/FCSK	-0.576419538922759
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1827	44/9376	0.816440264716127	POLE4/POLG/RFC2/PCNA/RFC3/NEIL1/POLE	-0.600380523381997
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1827	39/9376	0.789524651593617	MTHFD2L/AHCYL1/DLD/SHMT2/DHFR/GLDC	-0.647947860819996
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1827	21/9376	0.733130033622644	AASDHPPT/PANK3/ALDH2	-0.60227890418072
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1827	86/9376	0.835427247616502	CREB5/VAMP2/ATP1A1/ADCY4/RAPGEF4/CREB1/KCNMA1/ATF6B/RYR2/ATP1B3/ADCY6/KCNMB3/CAMK2G/GNAS	-0.754239894918282
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1827	75/9376	0.821105637657362	CREB5/ATP1A1/ADCY4/CREB1/GPX7/CANX/ATF6B/ATP1B3/ASGR1/ADCY6/GNAS/HSP90B1	-0.76519595075593
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1827	76/9376	0.810301616109239	APOA1/ACSL5/SCP2/ACSL3/CPT1A/RXRB/APOC3/MMP1/FABP4/SLC27A5/FABP5/PLIN1	-0.816844053969172
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1827	35/9376	0.733130033622644	AKR1B1/PFKL/HSD17B14/TIGAR/FCSK	-0.778121179142689
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/1827	29/9376	0.707849687635657	CALML4/CALM1/SLC24A1/CALM2	-0.775138720579552
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1827	16/9376	0.641488779419814	MAOA/GOT2	-0.70604928699343
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1827	89/9376	0.807266778595721	GABARAPL2/GNAI2/GNG12/ADCY4/GNG5/GNG11/GNG10/KCNJ6/SLC38A1/GNB4/SLC38A2/GNAI3/GABARAP/ADCY6	-0.898719283181851
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1827	48/9376	0.748403575989783	HIBCH/HSD17B10/DLD/MCCC2/ALDH2/BCKDHA/ACADSB	-0.859688294186329
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1827	23/9376	0.669379595916328	B4GALT3/POMGNT1/B4GAT1	-0.780959122569129
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1827	23/9376	0.669379595916328	AQP1/ATP1A1/ATP1B3	-0.780959122569129
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1827	102/9376	0.805005527115061	CPB1/ATP1A1/ADCY4/RAC1/SLC12A2/RAB8A/PLA2G2A/ATP2B1/RAP1A/KCNMA1/PRSS3/RYR2/RAB11A/ATP1B3/ADCY6/GNAS	-0.97408990098319
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/1827	67/9376	0.765956751546046	PGM2/G6PC3/PKM/PDHB/DLD/ALDH2/PFKL/MINPP1/GAPDH/ACSS2	-0.945784522770646
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1827	43/9376	0.716080497957002	ACSL5/ECI1/ACSL3/ALDH2/CPT1A/ACADSB	-0.917971121050804
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1827	17/9376	0.603754145336295	GGT5/ADO	-0.804423349504626
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1827	37/9376	0.693501383156556	PGM2/GNPNAT1/GALE/NANP/FCSK	-0.918944732147692
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	18/1827	116/9376	0.796330898590114	MDH2/HIBCH/SDHD/CS/PKM/PDHB/DLD/ACO2/PFKL/PGD/PGP/SHMT2/GOT2/GLYCTK/GAPDH/ACSS2/PSAT1/GLDC	-1.08582252763206
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/1827	75/9376	0.752680167852582	ARG2/CS/PKM/ACO2/PFKL/PYCR2/SHMT2/GOT2/GAPDH/PSAT1/ACY1	-1.05787645637693
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1827	93/9376	0.772545626828163	VAMP2/ATP1A1/ADCY4/CALML4/SLC12A2/ATP2B1/KCNMA1/CALM1/ATP1B3/ADCY6/GNAS/ADRB1/CALM2/CAMP	-1.08443066410005
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/1827	88/9376	0.758123102950689	THBD/PROS1/CFH/SERPINE1/VWF/A2M/SERPING1/CFI/CLU/CD59/TFPI/SERPINA5/VTN	-1.12146266642438
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1827	65/9376	0.710572186434255	PIK3R3/KRAS/KCNJ6/MAPK3/NRAS/ARRB1/HRAS/AKT3/GPER1	-1.15188461576385
Organismal Systems	Digestive system	hsa04976	Bile secretion	13/1827	90/9376	0.741275922885118	AQP1/ATP1A1/ADCY4/LDLR/NCEH1/ABCG2/ABCB1/EPHX1/ATP1B3/ADCY6/GNAS/SLC27A5/ABCB4	-1.21326022668002
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1827	41/9376	0.625842711629087	SSBP1/RPA3/RAD51C/TOPBP1/RPA1	-1.18113401254562
NA	NA	hsa04081	Hormone signaling	35/1827	219/9376	0.820168302454557	PRL/RAMP2/SMAD9/LEPR/GNAI2/GNG12/ADCY4/GNG5/GNG11/PIK3R3/GNG10/GNA13/RAPGEF4/ADIPOR1/SMAD1/RAMP3/SMAD5/GNB4/STAT5A/SMAD4/ADIPOR2/GNA12/ACVR1/NPR1/GNAI3/NPR3/HEPH/GHR/ADCY6/RAPGEF3/GPER1/AVPR2/GNAS/ADRB1/POMC	-1.32471329019695
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1827	20/9376	0.513191023535851	CYB5R3/NANP	-1.07210832465509
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1827	12/9376	0.427659186279876	NQO1	-0.975943860475161
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1827	21/9376	0.48875335574843	CSGALNACT1/CHST12	-1.15379438475484
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1827	36/9376	0.570212248373168	PGM2/G6PC3/GYG1/PGM2L1	-1.27098974361082
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1827	13/9376	0.394762325796809	DCLRE1C	-1.07423752099672
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/1827	50/9376	0.615829228243021	IL6/HLA-DMA/HLA-DRB1/MAP3K14/CD40/HLA-DRB5	-1.33989823752476
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1827	22/9376	0.466537294123501	MAOA/ALDH2	-1.23232971393648
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	40/1827	254/9376	0.808174840213939	KDR/NFATC1/ORAI1/NFATC2/ADCY4/FGFR1/CALML4/SLC25A5/ASPH/MYLK/ITPKC/VDAC3/FLT4/PDE1A/ORAI2/PDGFB/ATP2B1/HRH1/STIM2/CHRNA7/CAMK1D/NOS3/PDGFA/MET/PDGFD/CALM1/TFEB/RYR2/FLT1/ITPKB/PDE1C/CYSLTR1/CAMK2G/GRM5/GNAS/MCOLN3/ADRB1/CALM2/SPHK1/PPP3CA	-1.52471120593934
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1827	52/9376	0.592143488695213	ADCY4/LDLR/BMP6/AKR1C3/ADCY6/GNAS	-1.45083538313904
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1827	31/9376	0.496636474389533	ALDH2/HSD17B14/KL	-1.38096647652881
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1827	31/9376	0.496636474389533	HIBCH/SMOX/ALDH2	-1.38096647652881
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1827	48/9376	0.534573982849845	ATP1A1/PIK3R3/G6PC3/AKT3/ATP1B3	-1.59032983210248
Cellular Processes	Cell motility	hsa04814	Motor proteins	28/1827	194/9376	0.740688075206383	TUBB6/MYO1D/KIFC3/KIF9/MYO1B/KLC1/MYL12A/TUBB2A/DYNLRB1/MYO6/DYNLL2/ACTR10/TPM3/TUBA1A/DYNC1LI1/CAPZA2/DCTN6/KIF26B/MYH10/TUBA4A/TUBG1/TUBE1/DYNLL1/KIF22/MYO1E/DNAL1/MYL12B/KIF4A	-1.79541524612745
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1827	26/9376	0.394762325796809	HHEX/NR5A2	-1.52025703378096
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1827	36/9376	0.427659186279876	DCXR/AKR1B1/KL	-1.69255475833047
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1827	37/9376	0.416100829893933	MAOA/COMT/GOT2	-1.75064759508671
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1827	63/9376	0.48875335574843	GGT5/AKR1C3/PLA2G2A/LTC4S/PTGES2/PRXL2B	-2.00293171254852
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1827	42/9376	0.366565016811322	MAOA/DLD/ALDH2	-2.02396496667924
NA	NA	hsa04382	Cornified envelope formation	28/1827	217/9376	0.662181965852711	CLDN5/S100A10/ITGA6/PPP2R1A/ELOVL1/DSP/KRT10/FURIN/PPP2R1B/KRT18/LAMA5/KDSR/JUP/PPP2R3C/SPTLC1/UGCG/S100A11/KRT23/GBA2/PPP2R2A/KRT8/S100A1/CLDN15/PPP2R5B/ITGB4/CLDN10/CLDN3/LAMC2	-2.4768452136928
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/1827	99/9376	0.518374771248334	ICAM1/CFH/KRT10/KRT18/CFI/HLA-DMA/KRT23/HLA-DRB1/HLA-DRB5/CAMP	-2.36991760140094
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1827	26/9376	0.197381162898404	PLA2G2A	-2.01604590156289
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1827	37/9376	0.277400553262622	FOLH1/GOT2	-2.16649902655622
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	24/1827	195/9376	0.631619721274894	PIK3R3/SLC25A5/GSDMD/RAC1/VWF/HDAC7/MAPK3/VDAC3/MAPK14/RELA/HDAC1/HDAC2/MAPK12/MAP3K7/HAT1/MTOR/CLCN3/CASP1/AKT3/CLCN5/HDAC6/CLCN4/CAMP/HDAC9	-2.55728354015443
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/1827	103/9376	0.498243712170729	CPB1/SLC3A2/ATP1A1/PRCP/SLC38A2/ELN/MME/PRSS3/ATP1B3/SLC1A1	-2.51890335738546
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1827	66/9376	0.388781078436251	COMT/AKR1C3/HSD17B12/HSD17B11/CYP3A5	-2.45134318808584
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1827	30/9376	0.17106367451195	PLA2G2A	-2.2370676101286
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1827	68/9376	0.377346340835185	DHRS4L2/DGAT1/RETSAT/RDH13/CYP3A5	-2.53502947284281
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1827	70/9376	0.366565016811322	MGST2/MGST3/EPHX1/CYP3A5/GSTM4	-2.61685548725738
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	42/1827	323/9376	0.667307213266432	FSCN1/EFNA1/HOXD10/CDC25B/MMP9/SHC1/RASSF1/CDKN1A/PIK3R3/RPS6KA5/KRAS/NOTCH4/NOTCH1/ITGA5/SOX4/THBS1/CRK/SPRY2/SLC7A1/MAPK3/STMN1/NRAS/SOS2/CCNG1/HDAC1/MYC/HDAC2/PDGFB/ABCB1/PRKCE/MTOR/HRAS/PDGFA/MET/MAPK7/PAK4/MMP16/FOXP1/ZFPM2/BMF/TGFB2/BCL2L2	-2.99335747789739
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1827	73/9376	0.351500701051953	MGST2/MGST3/MAOA/CYP3A5/GSTM4	-2.73633729491205
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1827	79/9376	0.324804445275855	MGST2/MGST3/EPHX1/CYP3A5/GSTM4	-2.96470785286837
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1827	41/9376	0.125168542325817	CHRNA7	-2.76165458222881
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	18/1827	183/9376	0.504778055936903	NXT1/NOP10/SNU13/RRP7A/RPP30/CSNK2B/EIF6/GTPBP4/IMP3/RPP40/REXO1/XRN2/NHP2/AK6/NOB1/POP7/GAR1/RIOK1	-3.32818144255036
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/1827	86/9376	0.298366874148751	ADCY4/PDE1A/ADCY6/PDE1C/SCN9A	-3.21559728113471
NA	NA	hsa04082	Neuroactive ligand signaling	19/1827	199/9376	0.489981379255335	GNAI2/GNG12/ADCY4/GNG5/GNG11/GNG10/GNB4/HRH1/GNAI3/CHRNA7/SLC1A1/ADCY6/GRM5/SLC1A2/GNAS/GRIK4/ADRB1/POMC/GRM2	-3.57744037386269
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/1827	143/9376	0.28709987330677	SNRPB/SNRPD3/RO60/ACTN4/HLA-DMA/HLA-DRB1/CD40/HLA-DRB5	-4.22605837813475
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	23/1827	370/9376	0.319010636252016	PRL/S1PR1/LEPR/EDN1/PGRMC1/NR3C1/LPAR6/RXFP1/ADM/HRH1/CHRNA7/PGRMC2/GAL/PRSS3/GHR/CYSLTR1/AVPR2/LTB4R/GRM5/GRIK4/ADRB1/POMC/GRM2	-6.57484348286933
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/1827	449/9376	0.11429644176745	CALML4/PDE1A/ARRB1/ANO2/CALM1/PDE1C/CAMK2G/CALM2/OR52N1/PDE2A	-9.46169603208114