category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	87/1241	333/9376	1.97388040740176	SPP1/WNT3A/PTEN/HES1/ITGA1/COL6A1/LAMC1/COL6A2/COL1A2/PDGFRB/WNT2/COL1A1/WNT6/TNXB/NOTCH3/ITGA11/HEY2/RBPJ/HEYL/CCND2/FZD7/HLA-F/CDK2/ITGA9/PTK2/COL4A5/HLA-E/FZD2/EP300/MAML1/CHD4/LAMB2/CREB3L2/JAG1/HES4/ITGA3/NOTCH2/LAMA5/MAPK1/UBE3A/TSC1/EIF4EBP1/CDKN1B/APC/LAMC3/CREB3L1/PIK3CA/PIK3R2/ITGA4/AXIN2/RB1/AKT1/HRAS/HLA-A/IFNAR1/ATM/PRKACA/PPP2CB/CCND1/CDK4/HLA-B/ATP6AP1/DVL3/FZD1/SOS1/PPP2R1A/CREBBP/TSC2/NFX1/SOS2/SCRIB/ITGA10/UBR4/HDAC1/CDK6/RPS6KB1/COL6A6/DVL2/PSMC1/AKT3/RBL2/TNFRSF1A/MAP2K2/IRF3/PPP2R5A/LLGL2/FZD6	7.0674741778239
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	61/1241	203/9376	2.27028099855908	SPP1/HGF/PTEN/PDGFD/ITGA1/COL6A1/LAMC1/COL6A2/JUN/ARHGAP5/COL1A2/PDGFRB/SHC2/PPP1R12A/COL1A1/TNXB/ITGA11/PPP1R12B/ACTN4/CCND2/PDGFA/IGF1R/MYLK/ITGA9/PTK2/COL4A5/ARHGAP35/BCAR1/VCL/LAMB2/PPP1R12C/ITGA3/TLN1/LAMA5/MAPK1/ROCK2/LAMC3/PIK3CA/PIK3R2/ITGA4/CRKL/ROCK1/AKT1/HRAS/PDGFB/FLNA/DOCK1/RAC3/CCND1/SOS1/ILK/SOS2/PPP1CC/ITGA10/RAPGEF1/COL6A6/AKT3/PDGFC/RHOA/RAC1/CRK	7.14635973915355
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	53/1241	166/9376	2.41220158636156	AGTR1/EDNRB/MEF2C/PPP1R12A/GUCY1B1/ATP1B2/TRPC6/GTF2I/NFATC4/IRS1/GATA4/GUCY1A1/GUCY1A2/ATF4/MYLK/KCNMB2/ATF6B/ADCY5/ATP2A2/ADCY6/SLC25A6/CREB3L2/ADRB3/ADCY9/SRF/MAPK1/ROCK2/CREB3L1/PDE5A/ATP1A2/ITPR2/ROCK1/AKT1/CACNA1C/ATP2B4/MEF2D/ADCY3/CALM3/ADCY4/ITPR1/PPP1CC/GNAI3/ATF2/AKT3/SLC25A5/PDE2A/KCNJ8/MAP2K2/RHOA/EDNRA/CACNA1D/GNA12/GNAI1	7.1699095048678
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	61/1241	224/9376	2.05744215494417	PTEN/JUN/CANX/NFATC4/TGFB2/CCND2/ATF4/GPS2/XPO1/ATF6B/HLA-F/CDK2/TGFBR2/ADCY5/FOS/HLA-E/EP300/ADCY6/SLC25A6/TGFBR1/CREB3L2/SMAD4/EGR2/TLN1/ADCY9/SRF/BCL2L1/MAPK1/MSX2/CREB3L1/ELK4/PIK3CA/PIK3R2/CDKN2C/RB1/MSX1/AKT1/MAP3K3/HRAS/ADCY3/HLA-A/ANAPC13/ATM/PRKACA/TCF3/ADCY4/CCND1/CDK4/HLA-B/KAT2A/CREBBP/KAT5/ATF2/AKT3/SLC25A5/TNFRSF1A/LTBR/MAP2K2/CDC16/CD4/CDKN2B	6.25626841753369
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	35/1241	99/9376	2.67102939141618	JUN/SHC2/NOTCH3/IGF1R/PTK2/ADCY5/FOS/ADCY6/JAG1/NOTCH2/SP1/ADCY9/MAPK1/CDKN1B/PIK3CA/HBEGF/PIK3R2/CARM1/CDKN2C/RB1/AKT1/HRAS/ADCY3/PRKACA/ADCY4/CCND1/CDK4/MED1/GPER1/SOS1/DLL1/SOS2/RPS6KB1/AKT3/MAP2K2	6.52815801444021
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	47/1241	155/9376	2.29093083101557	AGTR1/WNT3A/KCNK3/KMT2A/WNT2/WNT6/PDE8B/FZD7/ATF4/ATF6B/CDK2/ADCY5/FZD2/ADCY6/CREB3L2/SP1/ADCY9/MAPK1/CDKN1B/APC/CREB3L1/CDKN2C/ITPR2/AXIN2/RB1/CACNA1C/CACNA1H/ADCY3/AHR/KMT2D/PRKACA/ADCY4/CCND1/CDK4/ITPR1/SCARB1/DVL3/FZD1/GNAI3/CDK6/ATF2/DVL2/MAP2K2/CACNA1D/GNAI1/CDKN2B/FZD6	6.32954601490398
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	44/1241	144/9376	2.30853254543827	WNT3A/WNT2/WNT6/ZFHX3/IL6ST/RIF1/KLF4/TBX3/FZD7/IGF1R/PCGF3/LEFTY2/ACVR2B/FZD2/KAT6A/SMAD4/STAT3/MAPK1/APC/BMPR2/ACVR2A/PCGF2/LIFR/PIK3CA/PIK3R2/AXIN2/REST/AKT1/HRAS/TCF3/MEIS1/SMAD5/FGFR1/DVL3/FZD1/FGF2/BMPR1A/DVL2/AKT3/MAP2K2/LEFTY1/DUSP9/PCGF5/FZD6	6.18031523218953
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	60/1241	232/9376	1.95393036761233	PDGFD/ITGA1/MYH11/PDGFRB/PPP1R12A/ARHGEF12/CFL2/ITGA11/NCKAP1/PPP1R12B/ACTN4/PDGFA/ARHGEF6/MYLK/GNG12/ITGA9/WASF2/PTK2/PIP4K2B/ARHGAP35/BCAR1/VCL/PPP1R12C/ITGA3/MAPK1/ROCK2/APC/PIKFYVE/ABI2/PIK3CA/PIK3R2/ITGA4/CRKL/ROCK1/AKT1/HRAS/PDGFB/DOCK1/RAC3/CYFIP1/MYH10/IQGAP2/FGFR1/ARHGEF7/SOS1/SOS2/PPP1CC/ITGA10/FGF2/WASL/AKT3/SCIN/PDGFC/LPAR5/MYH9/MAP2K2/RHOA/RAC1/GNA12/CRK	5.74626047559936
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	59/1241	227/9376	1.96368567341245	ARHGEF12/NFATC4/CCL3/ATF4/ATF6B/GNG12/HLA-F/PTK2/PTGER2/CCL4/ADCY5/HLA-E/BCAR1/ADCY6/CREB3L2/SP1/ADCY9/STAT3/MAPK1/TSC1/ROCK2/EIF4EBP1/CREB3L1/PIK3CA/PIK3R2/CRKL/ITPR2/ROCK1/RB1/AKT1/HRAS/ADCY3/HLA-A/RAC3/PRKACA/CALM3/ADCY4/CCND1/CDK4/ITPR1/HLA-B/CCR1/SOS1/GNB4/TSC2/SOS2/GNAI3/CDK6/RPS6KB1/ATF2/AKT3/TNFRSF1A/MAP2K2/IRF3/RHOA/RAC1/GNA12/CRK/GNAI1	5.74056009518127
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	38/1241	122/9376	2.35325821323364	PLCG2/SHC2/IRS1/ATF4/ATF6B/IGFBP3/PTK2/ADCY5/FOS/BCAR1/EP300/ADCY6/CREB3L2/ADCY9/STAT3/MAPK1/CREB3L1/PIK3CA/PIK3R2/CRKL/ITPR2/AKT1/CACNA1C/HRAS/ADCY3/PRKACA/ADCY4/ITPR1/SOS1/CREBBP/SOS2/GNAI3/ATF2/AKT3/MAP2K2/CACNA1D/CRK/GNAI1	5.876092039204
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	28/1241	77/9376	2.74734451688521	SHC2/TGFB2/CTBP2/TGFBR2/TGFBR1/SMAD4/BCL2L1/MAPK1/CDKN1B/PIK3CA/ABL1/PIK3R2/CRKL/BCR/PTPN11/RB1/AKT1/HRAS/CCND1/CDK4/POLK/SOS1/SOS2/HDAC1/CDK6/AKT3/MAP2K2/CRK	6.01310144252258
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	43/1241	148/9376	2.19509114271403	WNT3A/PTEN/HES1/JUN/WNT2/SHC2/WNT6/NOTCH3/HEY2/HEYL/FZD7/LRP6/IGF1R/FOS/FZD2/JAG1/NOTCH2/SP1/MAPK1/APC/PIK3CA/PIK3R2/AXIN2/RB1/AKT1/HRAS/KIT/CCND1/CDK4/FGFR1/POLK/DVL3/FZD1/SOS1/DLL1/SOS2/FGF2/CDK6/RPS6KB1/DVL2/AKT3/MAP2K2/FZD6	5.72362066170943
NA	NA	hsa04518	Integrin signaling	44/1241	154/9376	2.15862783469552	SPP1/HGF/PDGFD/ITGA1/COL6A1/LAMC1/COL6A2/COL1A2/PDGFRB/COL1A1/TNXB/ITGA11/NCK2/ACTN4/CCND2/PDGFA/ARHGEF6/IGF1R/ITGA9/PTK2/COL4A5/VCL/LAMB2/ITGA3/TLN1/LAMA5/FBN1/LAMC3/PIK3CA/PIK3R2/ITGA4/AKT1/PDGFB/FLNA/RAC3/FRAS1/CCND1/ILK/ITGA10/LIMS2/COL6A6/AKT3/PDGFC/RAC1	5.66219092666751
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	29/1241	83/9376	2.63976777375416	CSNK2B/PCGF3/BCOR/OGT/CBX7/EP300/RING1/CBX4/PHF1/MGA/YY1/PCGF2/SUZ12/ASXL1/USP7/ASXL2/FOXK1/CBX8/DCAF7/AEBP2/CREBBP/HCFC1/FBRSL1/HDAC1/RBBP4/FBRS/RBBP7/PHC3/PCGF5	5.86052030417019
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	59/1241	233/9376	1.9131186603632	NID1/COL3A1/ITGA1/COL6A1/MYH11/COL6A2/SDC2/PDLIM5/COL1A2/COL5A1/COL1A1/ITGA11/ATP1B2/FHL1/TNNT2/SUN1/PDLIM3/SGCA/ITGA9/COL4A5/PLEC/VCL/SYNPO2/ITGA3/TLN1/TNNT3/LMOD1/CAPZB/FBN1/ENO2/TMOD3/ATP1A2/LDB3/OBSCN/ITGA4/ELN/PDLIM7/TPM2/SYNE2/COL5A2/DSP/SYNE3/MYH10/FMNL3/CSRP2/MYOZ3/TMEM43/ITGA10/TPM4/COL6A6/FLNC/FMNL2/COL27A1/MYH9/DAAM2/SDC1/ACTG2/MYOM1/SNTA1	5.51256304037111
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	44/1241	157/9376	2.1173801690644	PTEN/NFATC4/GATA4/TGFB2/CCND2/HIPK2/ZFP36L1/RAD50/HLA-F/IGFBP3/CDK2/HIPK3/TGFBR2/HLA-E/SIRT1/SLC25A6/TGFBR1/MAPK1/TSC1/EIF4EBP1/PIK3CA/PIK3R2/ITPR2/RB1/AKT1/HRAS/HLA-A/ATM/CALM3/CCND1/CDK4/ITPR1/HLA-B/TSC2/PPP1CC/RBBP4/CDK6/AKT3/SLC25A5/RBL2/MAP2K2/LIN37/CACNA1D/CDKN2B	5.51444270022808
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	53/1241	204/9376	1.96286991831382	HGF/PLCG2/WNT3A/SDC2/COL1A2/WNT2/PPP1R12A/COL1A1/WNT6/ARHGEF12/TWIST1/EIF4B/GPC3/HPSE2/PPP1R12B/TGFB2/FZD7/IGF1R/PTK2/FZD2/PTCH1/PPP1R12C/STAT3/MAPK1/ROCK2/PIK3CA/HBEGF/PIK3R2/ITPR2/PTPN11/ROCK1/AKT1/HRAS/FLNA/PRKACA/CCND1/ITPR1/FRS2/FGFR1/FZD1/SOS1/SOS2/PPP1CC/FGF2/RPS6KB1/AKT3/TFAP4/MAP2K2/RHOA/RAC1/SDC1/PLCE1/FZD6	5.43054516266749
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	70/1241	300/9376	1.76287939833468	HGF/PDGFD/JUN/AREG/PDGFRB/CSF1R/MEF2C/DUSP8/NGFR/CD14/TGFB2/RPS6KA2/PDGFA/MAP3K20/ATF4/IGF1R/GNG12/TGFBR2/ARTN/FOS/TGFBR1/TAOK1/NTF3/SRF/RAPGEF2/MAPK1/MAP2K7/ELK4/PPM1A/CRKL/DUSP16/AKT1/CACNA1C/MAP3K3/CACNA1H/HRAS/PDGFB/FLNA/RAC3/PRKACA/KIT/MAP3K11/FGFR1/DUSP3/MAP4K3/SOS1/NRTN/SOS2/TAOK2/FGF2/PLA2G4B/NF1/MAP4K4/STMN1/ATF2/AKT3/GDNF/TNFRSF1A/PDGFC/MAP3K7/MAP2K2/DUSP4/DUSP9/RAC1/TAB2/MAPT/CACNA1D/GNA12/CRK/MAPKAPK3	5.24519961834006
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	46/1241	170/9376	2.04434753756458	HGF/PLCG2/WNT3A/PTEN/WNT2/SHC2/WNT6/TGFB2/FZD7/LRP6/IGF1R/TGFBR2/FZD2/TGFBR1/SMAD4/BCL2L1/MAPK1/ARID1B/APC/SMARCC2/PIK3CA/PHF10/PIK3R2/AXIN2/GSTM3/RB1/SMARCE1/AKT1/HRAS/SMARCA4/ARID1A/CCND1/CDK4/POLK/DVL3/FZD1/SOS1/SMARCB1/SOS2/SMARCC1/CDK6/RPS6KB1/DVL2/AKT3/MAP2K2/FZD6	5.36694040403127
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	25/1241	70/9376	2.6982847933694	HGF/JUN/EGLN3/EGLN1/TGFB2/EGLN2/EP300/EPAS1/MAPK1/PIK3CA/PIK3R2/CRKL/FLCN/PTPN11/AKT1/HRAS/PDGFB/SOS1/CREBBP/SOS2/RAPGEF1/AKT3/MAP2K2/RAC1/CRK	5.57019972002937
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	80/1241	362/9376	1.66965688871477	SPP1/HGF/PTEN/PDGFD/ITGA1/COL6A1/LAMC1/COL6A2/AREG/COL1A2/PDGFRB/PRLR/CSF1R/COL1A1/TNXB/ITGA11/EIF4B/NGFR/IRS1/CCND2/PDGFA/ATF4/IGF1R/ATF6B/GNG12/CDK2/ITGA9/PTK2/COL4A5/ARTN/BCL2L11/LAMB2/CREB3L2/PKN2/ITGA3/NTF3/LAMA5/BCL2L1/MAPK1/TSC1/EIF4EBP1/CDKN1B/LAMC3/CREB3L1/PIK3CA/PIK3R2/ITGA4/AKT1/HRAS/PDGFB/IFNAR1/PPP2CB/KIT/PCK2/CCND1/CDK4/FGFR1/SOS1/NRTN/PPP2R1A/GNB4/TSC2/SOS2/ITGA10/FGF2/CDK6/RPS6KB1/ATF2/COL6A6/AKT3/RBL2/GDNF/EPOR/PDGFC/LPAR5/PKN1/MAP2K2/STK11/RAC1/PPP2R5A	5.07505320348577
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	35/1241	117/9376	2.26010179273676	INO80D/BAZ2A/BPTF/SRCAP/CHD4/H2AZ2/SMARCA5/H2AZ1/ARID1B/YY1/SMARCC2/GATAD2B/PHF10/SMARCE1/MACROH2A1/SMARCA4/RSF1/SS18L1/EP400/MBD3/MTA1/ARID1A/BAZ2B/SMARCB1/MACROH2A2/CHRAC1/HDAC1/RBBP4/SMARCC1/KAT5/BAZ1B/RBBP7/EPC2/TFPT/SMARCA1	5.35684732262737
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	52/1241	205/9376	1.91644032153456	JUN/IL6ST/RBPJ/ACTN4/CCND2/ATF4/MRPS18B/ATF6B/HLA-F/CDK2/GTF2H1/HLA-E/EP300/CHD4/CREB3L2/HDAC5/HDAC9/EGR2/SRF/STAT3/MAPK1/UBE3A/CDKN1B/CREB3L1/PIK3CA/PIK3R2/RB1/HRAS/USP7/HLA-A/PRKACA/GTF2H2/CCND1/CDK4/HLA-B/KAT2A/HDAC6/CREBBP/SCRIB/UBR4/HDAC1/CDK6/ATF2/PSMC1/RBL2/SCIN/LTBR/DNAJA3/IRF3/RHOA/RAC1/CDKN2B	5.18161955620378
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	23/1241	62/9376	2.80273452730628	HES1/NOTCH3/HEY2/SPEN/RBPJ/HEYL/NCOR2/CTBP2/NRARP/EP300/MAML1/JAG1/NOTCH2/DTX3/ITCH/PSEN2/KAT2A/DVL3/DLL1/CREBBP/HDAC1/DVL2/NCSTN	5.56227241721365
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	27/1241	80/9376	2.54987912973409	HGF/PLCG2/GAS6/PTEN/PDGFD/PDGFRB/SHC2/PDGFA/IGF1R/BCL2L11/STAT3/BCL2L1/MAPK1/EIF4EBP1/PIK3CA/PIK3R2/AKT1/HRAS/PDGFB/SOS1/SOS2/FGF2/NF1/RPS6KB1/AKT3/PDGFC/MAP2K2	5.43735284499903
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	60/1241	250/9376	1.81324738114424	CLTC/FOLR2/EHD2/IGF1R/HLA-F/TGFBR2/HLA-E/SPG21/RAB11FIP2/TGFBR1/SH3GLB2/CAPZB/RAB10/AP2A2/RUFY1/AP2M1/WASHC4/RAB11FIP1/CYTH3/ITCH/SNX5/ARFGAP1/HRAS/IST1/RAB11FIP3/HLA-A/IGF2R/RABEP1/SNX2/VPS36/HLA-B/CLTA/SNX1/IQSEC1/ACAP3/PML/ARFGAP2/AP2B1/DNAJC6/RAB5C/SNX6/ARFGEF2/WASL/SPART/WWP1/AGAP1/SH3GLB1/EPN1/VPS37A/BIN1/RHOA/WIPF2/RAB5B/SNX3/AGAP3/RAB11B/DNM1/CHMP3/GRK5/VPS26A	5.09032130087426
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	38/1241	133/9376	2.15862783469552	PTEN/CSNK1E/IRS1/TGFB2/CCND2/IGF1R/PLK2/CDK2/TGFBR2/EP300/SIRT1/BCL2L11/DEPP1/TGFBR1/SMAD4/STAT3/MAPK1/CDKN1B/PIK3CA/PIK3R2/AKT1/HRAS/USP7/ATM/PCK2/SETD7/CCND1/SOS1/PRKAG1/CREBBP/SOS2/AKT3/RBL2/MAP2K2/FOXO6/STK11/CCNG2/CDKN2B	5.25600841646682
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	31/1241	99/9376	2.36576888954004	PDGFD/JUN/PDGFRB/DGKG/DGKD/PLPP3/PDGFA/WASF2/FOS/DGKH/SP1/MAPK1/TSC1/EIF4EBP1/PIK3CA/PIK3R2/AKT1/HRAS/PDGFB/RAC3/SOS1/TSC2/SOS2/PLA2G4B/RPS6KB1/AKT3/DGKE/LYPLA1/PDGFC/MAP2K2/RAC1	5.33560640400692
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	29/1241	90/9376	2.43445250246217	IRS1/ATF4/IGF1R/ATF6B/ADCY5/SIRT1/ADCY6/EHMT2/CREB3L2/ADCY9/TSC1/EIF4EBP1/CREB3L1/PIK3CA/PIK3R2/AKT1/HRAS/RB1CC1/ULK1/ADCY3/PRKACA/ADCY4/PRKAG1/TSC2/RPS6KB1/ATF2/AKT3/APPL1/STK11	5.34054818513149
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	38/1241	134/9376	2.14251867175003	AGTR1/MYH11/PPP1R12A/GUCY1B1/ARHGEF12/CALD1/PLA2G5/PLA2G2A/PPP1R12B/GUCY1A1/GUCY1A2/MYLK/KCNMB2/ADCY5/ADCY6/PPP1R12C/ADCY9/MAPK1/ROCK2/PPP1R14A/ITPR2/ROCK1/CACNA1C/ADCY3/PRKACA/CALM3/ADCY4/ITPR1/MYH10/PPP1CC/PLA2G4B/MYH9/MAP2K2/RHOA/EDNRA/CACNA1D/ACTG2/GNA12	5.20266034201652
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	28/1241	87/9376	2.43155779080645	JUN/AREG/TGFB2/TGFBR2/FOS/BCL2L11/TGFBR1/SMAD4/MAPK1/APC/PIK3CA/PIK3R2/AXIN2/AKT1/HRAS/RAC3/CCND1/POLK/SOS1/MSH6/SOS2/RPS6KB1/AKT3/APPL1/MAP2K2/BBC3/RHOA/RAC1	5.23934238480408
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	35/1241	122/9376	2.16747467008362	PLCG2/NOTCH3/ATP1B2/GATA4/RXRB/ATP2A2/EP300/SIN3A/NOTCH2/MED17/MAPK1/ATP1A2/PIK3CA/PIK3R2/THRA/AKT1/HRAS/MED16/PFKL/PRKACA/CCND1/MED1/MED14/MED13/KAT2A/CREBBP/TSC2/DIO3/HDAC1/AKT3/PFKP/MAP2K2/MED4/PFKM/PLCE1	5.06938627659098
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	29/1241	93/9376	2.3559217765763	TJP1/ARHGAP29/CSNK2B/ACTN4/CTNND1/HEG1/IGF1R/WASF2/TGFBR2/EP300/VCL/TGFBR1/SMAD4/MAPK1/ROCK2/CTNNA3/CTNNA1/ROCK1/LMO7/RAC3/FGFR1/KRIT1/CREBBP/WASL/NECTIN3/MAP3K7/RHOA/RAC1/CSNK2A2	5.13244950221922
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	28/1241	89/9376	2.37691604269844	PDGFD/TJP1/PDGFRB/GUCY1B1/TUBB4A/TUBB/GJA1/GUCY1A1/TUBA1B/PDGFA/GUCY1A2/ADCY5/ADCY6/ADCY9/MAPK1/ITPR2/HRAS/ADCY3/PDGFB/PRKACA/ADCY4/ITPR1/SOS1/SOS2/GNAI3/PDGFC/MAP2K2/GNAI1	5.09750300968719
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	40/1241	149/9376	2.02824091850586	AGTR1/PLCG2/PDGFD/PDGFRB/DGKG/SHC2/DGKD/PLPP3/PDGFA/ADCY5/DGKH/ADCY6/ADCY9/MAPK1/TSC1/CYTH3/PIK3CA/PIK3R2/AGPAT1/PTPN11/AKT1/HRAS/ADCY3/PDGFB/KIT/ADCY4/SOS1/TSC2/SOS2/PLA2G4B/AKT3/DGKE/PDGFC/LPAR5/AGPAT3/MAP2K2/RHOA/DNM1/GNA12/AGPAT5	4.94140564119614
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	34/1241	120/9376	2.14063926940639	PLCG2/JUN/SHC2/NGFR/IRS1/RPS6KA2/ATF4/NTF3/MAPK1/MAP2K7/KIDINS220/ZNF274/SORT1/PIK3CA/ABL1/PIK3R2/CRKL/PTPN11/AKT1/ARHGDIA/MAP3K3/HRAS/PSEN2/CALM3/FRS2/SOS1/SOS2/RAPGEF1/PRDM4/AKT3/MAP2K2/RHOA/RAC1/CRK	4.9115663984844
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	41/1241	157/9376	1.97301333935546	WNT3A/AREG/WNT2/WNT6/BMP6/CSNK1E/TGFB2/CCND2/FZD7/DLG5/GDF6/TGFBR2/SAV1/TEAD1/AJUBA/FZD2/TGFBR1/SMAD4/CTNNA3/APC/BMPR2/CTNNA1/AXIN2/PPP2CB/CCND1/MOB1B/YAP1/LATS1/DVL3/FZD1/PPP2R1A/SCRIB/PPP1CC/BMPR1A/DVL2/LIMD1/TEAD3/BBC3/WWTR1/LLGL2/FZD6	4.80197022909938
Organismal Systems	Immune system	hsa04611	Platelet activation	35/1241	126/9376	2.09866595039842	PLCG2/COL3A1/COL1A2/PPP1R12A/COL1A1/GUCY1B1/ARHGEF12/GUCY1A1/GUCY1A2/MYLK/ARHGAP35/ADCY5/ADCY6/TLN1/ADCY9/MAPK1/ROCK2/GP1BB/PIK3CA/PIK3R2/ITPR2/ROCK1/AKT1/TBXA2R/ADCY3/PRKACA/ADCY4/ITPR1/P2RY1/PPP1CC/GNAI3/PLA2G4B/AKT3/RHOA/GNAI1	4.84923042864592
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	43/1241	169/9376	1.92232833799808	PTEN/IRS1/IGF1R/SMCR8/BCL2L1/MAPK1/CTSD/ATG9A/TSC1/WIPI2/NBR1/VPS11/PIK3CA/PIK3R2/TAX1BP1/PLEKHM1/AKT1/LAMP1/HRAS/RB1CC1/ULK1/PRKACA/PPP2CB/ITPR1/RRAGD/EPG5/ATG2B/TSC2/STX7/RPS6KB1/AKT3/VPS33A/RRAGC/WDFY3/SH3GLB1/MAP3K7/PIK3R4/MAP2K2/SUPT20H/STK11/PIK3C3/BIRC6/ATG16L1	4.72566121179131
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	34/1241	122/9376	2.10554682236694	EEF2/EEF2K/IRS1/IGF1R/SIRT1/CREB3L2/TSC1/RAB10/EIF4EBP1/CREB3L1/RAB14/PIK3CA/PIK3R2/AKT1/ULK1/PFKL/PPP2CB/PCK2/CCND1/ACACA/PRKAG1/PPP2R1A/CAB39/TSC2/RPS6KB1/AKT3/PFKP/MAP3K7/TBC1D1/STK11/RAB11B/CPT1B/PPP2R5A/PFKM	4.80048435571998
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	35/1241	130/9376	2.03409161346309	EDNRB/COL3A1/JUN/COL1A2/SHC2/COL1A1/ATF4/ATF6B/GNG12/COL4A5/TGFBR2/ADCY5/FOS/ADCY6/TGFBR1/CREB3L2/ADCY9/MAPK1/MAP2K7/CREB3L1/PIK3CA/PIK3R2/AKT1/HRAS/ADCY3/PRKACA/ADCY4/SOS1/GNB4/SOS2/GNAI3/ATF2/AKT3/MAP2K2/GNAI1	4.63710038717018
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	31/1241	110/9376	2.12919200058604	PITX2/BMP6/LRRC32/TGFB2/BAMBI/GDF6/LEFTY2/TGFBR2/SKI/ACVR2B/EP300/TGFBR1/SMAD4/SIN3A/SP1/MAPK1/FBN1/BMPR2/ACVR2A/ROCK1/PPP2CB/SMAD5/PPP2R1A/CREBBP/SMAD6/HDAC1/BMPR1A/RPS6KB1/LEFTY1/RHOA/CDKN2B	4.65276092788208
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	40/1241	158/9376	1.91270820795806	WNT3A/PTEN/WNT2/WNT6/EIF4B/IRS1/RPS6KA2/FZD7/LRP6/IGF1R/FNIP1/FZD2/MAPK1/TSC1/EIF4EBP1/PIK3CA/PIK3R2/FLCN/FNIP2/AKT1/HRAS/ULK1/RRAGD/DVL3/FZD1/SOS1/CAB39/TSC2/SOS2/RPS6KB1/DVL2/AKT3/TNFRSF1A/RRAGC/MAP2K2/RHOA/STK11/CASTOR2/RNF152/FZD6	4.5189225503852
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	39/1241	154/9376	1.91332921711649	JUN/MEF2C/PPP1R12A/GUCY1B1/EEF2/NFATC4/EEF2K/PPP1R12B/GUCY1A1/GUCY1A2/MYLK/KCNJ5/ADCY5/FOS/ADCY6/PPP1R12C/ADCY9/MAPK1/ROCK2/ITPR2/ROCK1/CACNA1C/HRAS/ADCY3/PRKACA/CALM3/ADCY4/CCND1/ITPR1/PRKAG1/KCNJ12/PPP1CC/GNAI3/PLA2G4B/MAP2K2/RHOA/CACNA1D/TRPM2/GNAI1	4.46342151582809
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	38/1241	150/9376	1.91398334676336	HGF/WNT3A/WNT2/SHC2/WNT6/TGFB2/FZD7/LRP6/CDK2/RXRB/TGFBR2/FZD2/TGFBR1/SMAD4/MAPK1/CDKN1B/CTNNA3/APC/PIK3CA/CTNNA1/PIK3R2/AXIN2/RB1/AKT1/HRAS/CCND1/POLK/DVL3/FZD1/SOS1/SOS2/FGF2/RPS6KB1/DVL2/AKT3/MAP2K2/CDKN2B/FZD6	4.40727284343189
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	21/1241	65/9376	2.44090993615571	AGTR1/KCNK3/PDE8B/ATF4/ATF6B/ADCY5/ADCY6/CREB3L2/SP1/ADCY9/CREB3L1/ITPR2/CACNA1C/CACNA1H/ADCY3/PRKACA/ADCY4/ITPR1/SCARB1/ATF2/CACNA1D	4.55289989418562
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	35/1241	138/9376	1.91617325905943	PPP1R3C/PRKAR2B/SHC2/PPP1R3B/FLOT1/IRS1/PRKAR1A/GCK/TRIP10/MAPK1/TSC1/EIF4EBP1/PIK3CA/PIK3R2/CRKL/AKT1/HRAS/RHOQ/PRKACA/CALM3/PCK2/INPP5A/ACACA/INPPL1/SOS1/PRKAG1/TSC2/SOS2/PPP1CC/RAPGEF1/RPS6KB1/AKT3/MAP2K2/EXOC7/CRK	4.23468320176953
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	35/1241	139/9376	1.90238783992951	JUN/SHC2/ATF4/ATF6B/KCNJ5/ADCY5/FOS/ADCY6/GABBR1/CREB3L2/FKBP4/SP1/ADCY9/MAPK1/CTSD/CREB3L1/PIK3CA/HBEGF/PIK3R2/ITPR2/AKT1/HRAS/ADCY3/PRKACA/CALM3/ADCY4/ITPR1/GPER1/SOS1/SOS2/GNAI3/ATF2/AKT3/MAP2K2/GNAI1	4.18627653150361
Human Diseases	Cancer: specific types	hsa05218	Melanoma	22/1241	73/9376	2.27690881193911	HGF/PTEN/PDGFD/PDGFRB/PDGFA/IGF1R/MAPK1/PIK3CA/PIK3R2/RB1/AKT1/HRAS/PDGFB/CCND1/CDK4/FGFR1/POLK/FGF2/CDK6/AKT3/PDGFC/MAP2K2	4.27762346996438
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	23/1241	78/9376	2.2278146242691	CLTC/SHC2/SEPTIN9/WASF2/PTK2/SEPTIN2/BCAR1/VCL/CTNNA3/PIK3CA/CTNNA1/PIK3R2/CRKL/DOCK1/CLTA/ILK/SEPTIN8/SEPTIN11/WASL/RHOA/RAC1/DNM1/CRK	4.25283058527762
NA	NA	hsa04519	Cadherin signaling	79/1241	404/9376	1.47737771359731	WNT3A/TJP1/PDGFRB/PCDH10/WNT2/CDH19/WNT6/GJA1/NCKAP1/PCDH18/ACTN4/CTNND1/RERE/FZD7/LRP6/PCDHGA3/IGF1R/PCDHGA10/ATN1/PTK2/AMOTL1/SAV1/ARHGAP35/TEAD1/AJUBA/PCDH12/FZD2/EP300/VCL/TAOK1/GABRE/MYO1B/PCDH19/MAPK1/MYO1C/ROCK2/CTNNA3/APC/LHFPL6/GABRA3/ABI2/PCDH1/MPDZ/CTNNA1/AMOTL2/FAT1/AXIN2/ROCK1/HRAS/PSEN2/DSP/RAC3/CYFIP1/RYK/PCDHGA6/MOB1B/YAP1/LATS1/FGFR1/DVL3/FZD1/PCDHGB6/CREBBP/PCDHGB7/PPP1CC/TAOK2/DVL2/NCSTN/ANKRD6/MYO7A/MAP2K2/DAAM2/PCDHGA7/LIMD1/TEAD3/RHOA/RAC1/WWTR1/FZD6	3.83090110247456
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	28/1241	106/9376	1.99571252641661	PTEN/PDGFD/FOLR2/PDGFRB/PDGFA/ATF4/IGF1R/CDK2/EP300/CREB3L2/MAPK1/CDKN1B/CREB3L1/PIK3CA/PIK3R2/RB1/AKT1/HRAS/PDGFB/CCND1/FGFR1/SOS1/CREBBP/ETV5/SOS2/AKT3/PDGFC/MAP2K2	4.02661202910938
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	27/1241	101/9376	2.01970624137353	WNT3A/EDNRB/WNT2/WNT6/FZD7/ADCY5/FZD2/EP300/ADCY6/CREB3L2/ADCY9/MAPK1/CREB3L1/HRAS/ADCY3/PRKACA/CALM3/KIT/ADCY4/DVL3/FZD1/CREBBP/GNAI3/DVL2/MAP2K2/GNAI1/FZD6	4.02412586159661
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	41/1241	178/9376	1.74024210268993	FRZB/WNT3A/JUN/WNT2/WNT6/CSNK1E/NFATC4/CSNK2B/CCND2/FZD7/LRP6/CTBP2/BAMBI/CCN4/FZD2/EP300/SIRT1/SMAD4/TBL1XR1/ROCK2/APC/AXIN2/RAC3/PRKACA/GPC4/RYK/CCND1/LZTS2/DVL3/FZD1/CREBBP/CHD8/DVL2/ANKRD6/MAP3K7/SENP2/DAAM2/RHOA/RAC1/CSNK2A2/FZD6	3.89430382892612
Human Diseases	Cancer: specific types	hsa05214	Glioma	22/1241	76/9376	2.18703083252046	PLCG2/PTEN/PDGFRB/SHC2/PDGFA/IGF1R/MAPK1/PIK3CA/PIK3R2/RB1/AKT1/HRAS/PDGFB/CALM3/CCND1/CDK4/POLK/SOS1/SOS2/CDK6/AKT3/MAP2K2	4.05807502426205
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	34/1241	140/9376	1.83483365949119	SPP1/AGTR1/MEF2C/NOTCH3/MYLK/GNG12/ADCY5/ADCY6/TGFBR1/HDAC5/SMAD4/JAG1/ADCY9/MAPK1/ITPR2/AKT1/HRAS/MEF2D/ADCY3/PRKACA/CALM3/ADCY4/CCND1/ITPR1/PRKAG1/GNB4/GNAI3/RPS6KB1/AKT3/PIK3R4/MAP2K2/PIK3C3/TFAM/GNAI1	3.88700193660479
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	26/1241	98/9376	2.00444013221727	AGTR1/KCNK3/ATP1B2/ATF4/ATF6B/KCNJ5/ADCY5/ADCY6/CREB3L2/ADCY9/CREB3L1/ATP1A2/ITPR2/CACNA1C/ATP2B4/CACNA1H/ADCY3/PRKACA/CALM3/ADCY4/PRKD3/ITPR1/SCARB1/ATF2/PDE2A/CACNA1D	3.90393574160926
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	15/1241	44/9376	2.57563548457988	VAMP2/ADCY6/CREB3L2/ADCY9/CREB3L1/ARHGDIA/ADCY3/DCTN1/PRKACA/RAB5C/DYNC1LI2/DYNC1I2/RAB5B/NSF/RAB11B	4.09154636011492
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	20/1241	68/9376	2.22211688865715	CSF1R/CD14/ZBTB16/RUNX1T1/STAT3/MAPK1/EIF4EBP1/PIK3CA/PIK3R2/AKT1/HRAS/KIT/FCGR1A/CCND1/PML/SOS1/SOS2/RPS6KB1/AKT3/MAP2K2	3.95031533871434
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	29/1241	115/9376	1.90522369757909	MEF2C/LRP6/ATF4/ATF6B/RXRB/ADCY5/FOS/ADCY6/CREB3L2/WNK1/SP1/ADCY9/PTH1R/MAPK1/CREB3L1/HBEGF/MMP16/ITPR2/MEF2D/ADCY3/PRKACA/ADCY4/ITPR1/FGFR1/GNAI3/ATF2/RHOA/GNA12/GNAI1	3.81477249877962
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	33/1241	138/9376	1.80667764425603	JUN/ARHGEF12/RPS6KA2/IL18/WASF2/PTK2/FOS/BCAR1/PKN2/MAPK1/MAP2K7/ROCK2/PIK3CA/PIK3R2/ITGA4/CRKL/ROCK1/AKT1/DOCK1/RAC3/ARHGEF7/WASL/AKT3/PKN1/MAP3K7/MAP2K2/IRF3/RHOA/WIPF2/RAC1/CD4/TAB2/CRK	3.72857888570229
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	44/1241	201/9376	1.65387406240353	KMT2A/MAF/CSF1R/MEF2C/PROM1/NGFR/TAF15/EWSR1/CD14/MLLT1/CCND2/PDGFA/ZBTB16/IGF1R/NUPR1/IGFBP3/RXRB/PTK2/HOXA11/TGFBR2/RUNX1T1/SIN3A/SP1/BCL2L1/CDKN1B/NSD2/HOXA10/ELK4/CDKN2C/ETV1/LDB1/ATM/SS18L1/TCF3/MEIS1/FCGR1A/POLK/PML/MLLT3/ETV5/HDAC1/CCNT2/HHEX/CCNT1	3.6600064677737
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	36/1241	157/9376	1.73240195650723	GAS6/C1QA/BSG/STAB1/C1QB/DUSP8/LRP1/NFATC4/C1QC/PTK2/PTGER2/BCAR1/ATP2A2/SIRT1/ADGRB1/MAPK1/RAB14/VPS11/CRKL/DUSP16/PTPN11/TGFBRAP1/DOCK1/RAB5C/GULP1/PLA2G15/VPS33A/EPOR/MAP2K2/DUSP4/RAB5B/RAC1/CPT1B/DNMT3A/CRK/ANO6	3.61451611055155
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	23/1241	86/9376	2.02057605456965	PLCG2/JUN/AREG/SHC2/NCK2/PTK2/MAPK1/MAP2K7/EIF4EBP1/CDKN1B/PIK3CA/HBEGF/ABL1/PIK3R2/CRKL/AKT1/HRAS/SOS1/SOS2/RPS6KB1/AKT3/MAP2K2/CRK	3.71346635417975
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	52/1241	253/9376	1.55284690084816	PLCG2/JUN/CD14/ACTN4/SEPTIN9/IL18/WASF2/PTK2/SEPTIN2/BCAR1/VCL/SEPTIN7/TLN1/GSK3A/BCL2L1/MAPK1/ROCK2/WIPI2/U2AF1/CYTH3/PIK3CA/PIK3R2/CRKL/ITPR2/NOD1/ROCK1/AKT1/DOCK1/ATM/ITPR1/RRAGD/ILK/SEPTIN8/SEPTIN11/WASL/RPS6KB1/AKT3/TNFRSF1A/RRAGC/RNF31/MAP3K7/PIK3R4/IRF3/FOXO6/RHOA/RAC1/PIK3C3/TAB2/CRK/PLCE1/ATG16L1/UBE2V2	3.48168160396362
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	45/1241	212/9376	1.60369756587049	HGF/PDGFD/PDGFRB/RAPGEF5/CSF1R/NGFR/CTNND1/PDGFA/IGF1R/ADCY5/BCAR1/ADCY6/TLN1/ADCY9/RAPGEF2/MAPK1/SIPA1/PIK3CA/PIK3R2/CRKL/AKT1/HRAS/ADCY3/PDGFB/RAC3/CALM3/KIT/RAPGEF6/ADCY4/PRKD3/FGFR1/KRIT1/P2RY1/GNAI3/FGF2/RAPGEF1/AKT3/PDGFC/LPAR5/MAP2K2/RHOA/RAC1/CRK/PLCE1/GNAI1	3.47246250724387
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	18/1241	62/9376	2.19344441267448	EIF4EBP2/IRS1/IGF1R/ADCY5/SIRT1/ADCY6/ADCY9/PIK3CA/PIK3R2/AKT1/HRAS/ADCY3/PRKACA/ADCY4/PRKAG1/HDAC1/RPS6KB1/AKT3	3.68232972606131
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	21/1241	78/9376	2.03409161346309	TOB2/PABPC4L/DDX6/BTG2/ENO2/PARN/EXOSC6/PFKL/DHX36/PATL1/CNOT3/TENT4A/XRN1/PFKP/DCP1A/CNOT1/DIS3/CNOT7/EXOSC10/PFKM/MTREX	3.58182445035859
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	17/1241	59/9376	2.17692129092176	PTEN/MAPK1/CTNNA3/APC/PIK3CA/CTNNA1/PIK3R2/AXIN2/AKT1/HRAS/CCND1/POLK/SOS1/ILK/SOS2/AKT3/MAP2K2	3.54183338993983
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	45/1241	217/9376	1.5667460090532	JUN/KLF4/RPS6KA2/ATF4/ATF6B/RXRB/ADCY5/FOS/ADCY6/CHRNA3/CREB3L2/JAG1/NOTCH2/ADRB3/ADCY9/STAT3/MAPK1/EIF4EBP1/CREB3L1/PIK3CA/PIK3R2/GSTM3/RB1/AKT1/CACNA1C/HRAS/ADCY3/AHR/PRKACA/PTGES3/ADCY4/CCND1/KPNA1/EPHX1/SOS1/DLL1/SOS2/GNAI3/FGF2/RPS6KB1/ATF2/AKT3/MAP2K2/CACNA1D/GNAI1	3.29903602721095
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	35/1241	158/9376	1.6736196819633	TGFB2/CCND2/CDK2/EP300/SMAD4/NIPBL/CDKN1B/RAD21/SMC3/ABL1/CDKN2C/RB1/STAG2/WAPL/ATRX/WEE1/MCM6/ANAPC13/ATM/PDS5B/PPP2CB/CCND1/CDK4/PPP2R1A/CREBBP/HDAC1/ESCO1/CDK6/RBL2/SMC1A/DDX11/MCM7/CDC16/PPP2R5A/CDKN2B	3.33516795911969
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	50/1241	250/9376	1.51103948428687	NEU1/CLTC/SCARB2/MCOLN2/TPP1/TPCN1/LGMN/TLR7/CTSO/ABCA5/SLC29A1/ASAH1/VPS13C/CTSD/AP2A2/AP3D1/AP2M1/PIKFYVE/CLCN7/VPS11/SORT1/CTSA/PLEKHM1/CLN3/LAMP1/DMXL2/M6PR/IGF2R/CLN6/CD164/AP3M2/RRAGD/GGA1/ATP6AP1/CLTA/ENTPD4/ZFYVE26/VAMP7/AP2B1/LAPTM4B/PLA2G15/VPS33A/RRAGC/PPT2/AP1B1/MAN2B1/GNPTG/MCOLN3/SLC29A3/VPS26A	3.19872554497885
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	27/1241	115/9376	1.77382895981502	ATF4/GNG12/ADCY5/FOS/ADCY6/CHRNA3/CREB3L2/ADCY9/MAPK1/CREB3L1/PIK3CA/PIK3R2/ITPR2/KCNQ4/AKT1/CACNA1C/HRAS/ADCY3/PRKACA/ADCY4/ITPR1/GNB4/KCNJ12/GNAI3/AKT3/CACNA1D/GNAI1	3.26105187320689
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	20/1241	77/9376	1.96238894063229	TGFB2/ARHGEF6/TGFBR2/TGFBR1/SMAD4/STAT3/BCL2L1/MAPK1/PIK3CA/PIK3R2/RB1/AKT1/RAC3/CCND1/CDK4/POLK/CDK6/RPS6KB1/AKT3/RAC1	3.3118496502908
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	35/1241	163/9376	1.62228165490921	JUN/NFATC4/TGFB2/ATF4/ATF6B/CDK2/TGFBR2/FOS/EP300/TGFBR1/CREB3L2/SMAD4/EGR2/STAT3/MAPK1/MAP2K7/CREB3L1/PIK3CA/PIK3R2/MAVS/RB1/AKT1/HRAS/IFNAR1/ATP6AP1/SOS1/STAT6/CREBBP/SOS2/ATF2/AKT3/MAP3K7/MAP2K2/IRF3/TAB2	3.13020668746505
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	49/1241	248/9376	1.49276078084791	JUN/AHNAK/TUBB4A/TUBB/NCKAP1/CD14/TUBA1B/DYNLRB1/IL18/FOS/MAPK1/MAP2K7/PIK3C2A/ROCK2/VPS11/KLC1/CYTH3/PIK3CA/PLEKHM1/NOD1/AKT1/HRAS/M6PR/FLNA/DCTN1/CYFIP1/ACTR1A/KPNA1/GCC2/GSDMD/RAB5C/DYNC1LI2/WASL/AKT3/TNFRSF1A/VPS33A/PKN1/MAP3K7/MAP2K2/EXOC7/DYNC1I2/RHOA/FBXO22/FYCO1/RAB5B/RAC1/PIK3C3/TAB2/TLR6	3.071615919481
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	22/1241	89/9376	1.86757689069163	SPP1/ITGA1/COL6A1/LAMC1/COL6A2/COL1A2/COL1A1/TNXB/ITGA11/ITGA9/COL4A5/LAMB2/ITGA3/LAMA5/GP1BB/LAMC3/ITGA4/FRAS1/SV2A/ITGA10/COL6A6/SDC1	3.21187034960287
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	19/1241	73/9376	1.96642124667469	MLLT1/XPO1/SERINC3/EP300/PSIP1/NELFE/CPSF7/KAT2A/MLLT3/ELL3/SMARCB1/CREBBP/CCNT2/CCNT1/FURIN/PPIA/MAP1S/CD4/NELFB	3.23749524476225
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	24/1241	101/9376	1.79529443677647	AGTR1/PLCG2/COL3A1/JUN/COL1A2/COL1A1/THBD/TGFB2/COL4A5/TGFBR2/TGFBR1/SMAD4/STAT3/MAPK1/CDKN1B/PIK3CA/PIK3R2/AKT1/HRAS/CCND1/CDK4/AKT3/RAC1/PLCE1	3.1385165460057
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1241	29/9376	2.60524049014977	CSNK1E/SAV1/TEAD1/AJUBA/MOB1B/YAP1/LATS1/LIMD1/TEAD3/WWTR1	3.38139365694986
Organismal Systems	Endocrine system	hsa04924	Renin secretion	18/1241	69/9376	1.97092106646113	AGTR1/GUCY1B1/GUCY1A1/GUCY1A2/PTGER2/ADCY5/ADCY6/ADRB3/ITPR2/CACNA1C/PRKACA/CALM3/ITPR1/GNAI3/AQP1/EDNRA/CACNA1D/GNAI1	3.16152312617878
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	7/1241	17/9376	3.11096364412002	MYH11/NRP2/CD209/PCDH1/LAMP1/MYH10/MYH9	3.40238332417206
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	22/1241	93/9376	1.78725100291995	JUN/ATF4/ADCY5/ADCY6/ADCY9/MAPK1/MAP2K7/HBEGF/ITPR2/CACNA1C/MAP3K3/HRAS/ADCY3/PRKACA/CALM3/ADCY4/ITPR1/SOS1/SOS2/PLA2G4B/MAP2K2/CACNA1D	2.97991085316175
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	22/1241	93/9376	1.78725100291995	PTEN/LAMC1/CDK2/RXRB/PTK2/COL4A5/LAMB2/ITGA3/LAMA5/BCL2L1/CDKN1B/LAMC3/PIK3CA/PIK3R2/RB1/AKT1/CCND1/CDK4/POLK/CDK6/AKT3/CDKN2B	2.97991085316175
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	18/1241	71/9376	1.91540216318053	PRLR/SHC2/CCND2/GCK/FOS/SOCS7/CISH/STAT3/MAPK1/PIK3CA/PIK3R2/AKT1/HRAS/CCND1/SOS1/SOS2/AKT3/MAP2K2	3.02395741086915
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	35/1241	170/9376	1.55548182206001	MYH11/JUN/TJP1/SYNPO/ACTN4/GATA4/TUBA1B/AMOTL1/ARHGAP17/YBX3/RAPGEF2/MAP2K7/JAM3/ROCK2/MPDZ/AMOTL2/ROCK1/PRKACA/PPP2CB/RAPGEF6/CCND1/CDK4/MYH10/PRKAG1/PPP2R1A/SCRIB/MYH9/WHAMM/RHOA/STK11/CLDN12/RAC1/CACNA1D/SYMPK/LLGL2	2.8546415127966
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	46/1241	238/9376	1.46024824111756	HGF/PLCG2/PDGFD/PDGFRB/RAPGEF5/CSF1R/SHC2/PLA2G5/NGFR/PLA2G2A/PDGFA/IGF1R/GNG12/RASA3/RGL2/NTF3/BCL2L1/MAPK1/PIK3CA/ABL1/PIK3R2/PTPN11/AKT1/HRAS/PDGFB/RAC3/PRKACA/CALM3/KIT/FGFR1/SOS1/RAB5C/GNB4/SOS2/FGF2/PLA2G4B/NF1/AKT3/PDGFC/MAP2K2/RALGAPB/RHOA/RAB5B/RAC1/PLCE1/SYNGAP1	2.80897445335745
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	39/1241	196/9376	1.50333009916295	PLCG2/JUN/IL6ST/NFATC4/GNG12/HLA-F/FOS/HLA-E/EP300/CD200R1/STAT3/MAPK1/MAP2K7/PIK3CA/PIK3R2/ITPR2/RB1/AKT1/HRAS/HLA-A/PDGFB/IFNAR1/CALM3/CCND1/CDK4/ITPR1/HLA-B/CCR1/CREBBP/GNB4/FGF2/CDK6/AKT3/MICA/TNFRSF1A/MAP2K2/IRF3/RAC1/PIK3C3	2.78132889323493
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	37/1241	184/9376	1.51925165539712	PLCG2/DPYSL2/SEMA6A/ARHGEF12/CFL2/SEMA6D/TRPC6/NCK2/SEMA4A/NFATC4/PLXNB2/PTK2/NTNG1/PTCH1/TRPC3/SEMA4C/SEMA4B/MAPK1/ROCK2/BMPR2/ROBO2/PIK3CA/ABL1/PIK3R2/SEMA5B/PTPN11/ROCK1/HRAS/PLXNB1/RAC3/RYK/ILK/GNAI3/RHOA/RAC1/LRIG2/GNAI1	2.77827060350832
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	32/1241	154/9376	1.56991115250583	AGTR1/ATP1B2/TNNT2/SCN7A/ATF4/ATF6B/ADCY5/ATP2A2/ADCY6/CREB3L2/ADCY9/MAPK1/CREB3L1/ATP1A2/TPM2/AKT1/CACNA1C/ATP2B4/ADCY3/PRKACA/CALM3/PPP2CB/ADCY4/PPP2R1A/PPP1CC/GNAI3/TPM4/ATF2/AKT3/CACNA1D/PPP2R5A/GNAI1	2.7851443406529
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	18/1241	73/9376	1.86292539158655	HGF/PLCG2/RXRB/STAT3/MAPK1/PIK3CA/PIK3R2/RB1/AKT1/HRAS/CCND1/CDK4/POLK/SOS1/SOS2/CDK6/AKT3/MAP2K2	2.89078583636153
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	16/1241	63/9376	1.91878029750713	KMT2A/NSD1/SETD2/ASH1L/EHMT2/KMT5B/KMT2C/NSD2/KMT2D/SETD7/ALDH3A2/SETD1B/SETD1A/COLGALT1/PLOD2/AASS	2.8577872684063
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	28/1241	133/9376	1.5905678781967	GNAL/ATF4/ATF6B/KCNJ5/GNG12/ADCY5/FOS/CREB3L2/GSK3A/CREB3L1/ITPR2/AKT1/CACNA1C/PRKACA/CALM3/PPP2CB/ITPR1/CLOCK/PPP2R1A/GNB4/PPP1CC/GNAI3/ATF2/AKT3/CALY/CACNA1D/PPP2R5A/GNAI1	2.67905676468797
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	24/1241	110/9376	1.64840671013113	PLCG2/EGLN3/EGLN1/IGF1R/EGLN2/EP300/EPAS1/STAT3/MAPK1/EIF4EBP1/CDKN1B/ENO2/PIK3CA/PIK3R2/AKT1/PDK1/PFKL/CREBBP/RPS6KB1/AKT3/PFKP/LTBR/MAP2K2/PFKM	2.67171694867564
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	25/1241	116/9376	1.6282753063436	PLCG2/ARHGAP5/ESAM/ACTN4/CTNND1/PTK2/ARHGAP35/BCAR1/VCL/JAM3/ROCK2/CTNNA3/SIPA1/PIK3CA/CTNNA1/PIK3R2/ITGA4/PTPN11/ROCK1/NCF4/GNAI3/RHOA/CLDN12/RAC1/GNAI1	2.65929331713924
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	41/1241	214/9376	1.44749109476078	PLCG2/JUN/CFL2/NFATC4/GNG12/HLA-F/PTK2/FOS/HLA-E/CUL4B/BCL2L1/MAPK1/MAP2K7/PIK3CA/PIK3R2/CRKL/ITPR2/AKT1/HRAS/HLA-A/WEE1/RAC3/ATM/CALM3/ITPR1/HLA-B/GNB4/GNAI3/RPS6KB1/AKT3/TNFRSF1A/CUL5/MAP3K7/MAP2K2/IRF3/AP1B1/RAC1/CD4/TAB2/CRK/GNAI1	2.58635949629065
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	16/1241	65/9376	1.85974090373768	SPP1/KCNJ5/GABBR1/MAPK1/PIK3CA/PIK3R2/ITPR2/AKT1/CACNA1C/CACNA1H/HRAS/ITPR1/GPER1/AKT3/MAP2K2/CACNA1D	2.71655720557912
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	17/1241	71/9376	1.80899093189273	PTEN/PDGFRB/GCK/GLS/MAPK1/PIK3CA/PIK3R2/AKT1/HRAS/PDK1/PFKL/KIT/FGFR1/AKT3/PFKP/MAP2K2/PFKM	2.67243646805812
Organismal Systems	Nervous system	hsa04730	Long-term depression	15/1241	60/9376	1.88879935535858	GUCY1B1/GUCY1A1/GUCY1A2/IGF1R/MAPK1/ITPR2/HRAS/PPP2CB/ITPR1/PPP2R1A/GNAI3/PLA2G4B/MAP2K2/GNA12/GNAI1	2.69747461584252
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	20/1241	89/9376	1.69779717335603	GNG12/GLS/TRAK2/ADCY5/ADCY6/GABBR1/SLC38A2/GABRE/ADCY9/GABRA3/CACNA1C/ADCY3/PRKACA/ADCY4/SLC6A1/GNB4/GNAI3/NSF/CACNA1D/GNAI1	2.58332612957477
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	26/1241	125/9376	1.57148106365834	PTEN/SGPP1/ASAH1/MAPK1/CTSD/ROCK2/PIK3CA/PIK3R2/ROCK1/AKT1/HRAS/RAC3/CERS2/PPP2CB/ABCC1/PPP2R1A/GNAI3/AKT3/TNFRSF1A/SPTLC1/MAP2K2/RHOA/RAC1/GNA12/PPP2R5A/GNAI1	2.51220607058084
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	18/1241	78/9376	1.74350709725408	C1QA/JUN/C2/C1QB/CFL2/CD14/C1QC/SERPING1/C1R/FOS/C4BPB/MAPK1/NOD1/CALM3/GNAI3/IRF3/RHOA/GNAI1	2.57531524798006
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	37/1241	193/9376	1.44840572328016	PLCG2/SHC2/CCL3/GNG12/PTK2/CCL4/ADCY5/BCAR1/ADCY6/CCL28/ADCY9/STAT3/GSK3A/MAPK1/ROCK2/PIK3CA/PIK3R2/CRKL/ROCK1/AKT1/HRAS/ADCY3/RAC3/PRKACA/ADCY4/CCR1/SOS1/GNB4/SOS2/GNAI3/AKT3/RHOA/RAC1/CRK/CCL13/GNAI1/GRK5	2.45838705145368
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	23/1241	108/9376	1.60897722863879	TPR/DDX39B/EEF1A1/XPO1/TNPO1/CASC3/IPO5/AHCTF1/RNPS1/SUMO3/POM121C/ACIN1/IPO7/KPNA1/XPO7/TNPO2/UPF2/UBE2I/THOC2/SRRM1/SENP2/UPF1/IPO9	2.48606608503169
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	21/1241	97/9376	1.63566129742393	GUCY1B1/GUCY1A1/GUCY1A2/KCNJ5/GNG12/ADCY5/FOS/ADCY6/ADCY9/MAPK1/CACNA1C/CACNA1H/ADCY3/PRKACA/CALM3/ADCY4/ITPR1/GNB4/GNAI3/CACNA1D/GNAI1	2.45784108783768
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	22/1241	103/9376	1.61373148807335	DDX39B/PCF11/PABPC4L/CASC3/TARDBP/CPSF7/WDR82/RNPS1/PPP2CB/ACIN1/CPSF1/CPSF2/MSI2/SSU72/PPP2R1A/UPF2/PPP1CC/RNMT/SRRM1/UPF1/SYMPK/PPP2R5A	2.44613058886536
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	23/1241	109/9376	1.59421596966045	PTEN/PPP1R3C/PPP1R3B/IRS1/MLXIP/RPS6KA2/OGA/OGT/CREB3L2/STAT3/CREB3L1/PIK3CA/PIK3R2/PTPN11/AKT1/PCK2/GFPT1/PRKAG1/PPP1CC/RPS6KB1/AKT3/TNFRSF1A/CPT1B	2.43714145601619
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	21/1241	98/9376	1.61897087602164	PLCG2/PTEN/DGKG/DGKD/PIP4K2B/DGKH/PIK3C2A/PIKFYVE/PIK3CA/PIK3R2/ITPR2/CALM3/INPP5A/ITPR1/INPPL1/IP6K1/DGKE/SACM1L/PIK3C3/OCRL/PLCE1	2.40574071904306
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	22/1241	104/9376	1.59821483914957	DGKG/PLA2G5/DGKD/PLA2G2A/PLPP3/PLD3/DGKH/AGPAT1/LPCAT2/MBOAT1/TAFAZZIN/PLA2G4B/SAMD8/DGKE/PLA2G15/LYPLA1/AGPAT3/LPGAT1/CRLS1/GDPD5/AGPAT5/GPAT4	2.39596180385642
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	16/1241	69/9376	1.75192983685434	JUN/ATF4/ATF6B/ADCY5/FOS/SIRT1/CREB3L2/CREB3L1/FOSB/CACNA1C/PRKACA/CALM3/PPP1CC/HDAC1/ATF2/CACNA1D	2.44844164020824
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	17/1241	75/9376	1.71251141552511	GPX3/CANX/ATP1B2/ATF4/ATF6B/ADCY5/ADCY6/CREB3L2/ADCY9/CREB3L1/ATP1A2/ITPR2/ADCY3/PRKACA/ADCY4/ITPR1/ATF2	2.41963794546475
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	22/1241	105/9376	1.58299374544338	JUN/CSNK2B/ATF4/FKBP8/SP1/BCL2L1/ATG9A/NBR1/TAX1BP1/HRAS/ULK1/BNIP3L/TBC1D17/HUWE1/RAB5C/RHOT2/MFN2/RAB5B/CSNK2A2/TOMM70/TBC1D15/OPA1	2.34632411835195
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1241	53/9376	1.85316163167257	CLTC/ATP1B2/ADCY6/ADCY9/PTH1R/AP2A2/AP2M1/ATP1A2/ATP2B4/PRKACA/CLTA/AP2B1/DNM1	2.43267537604305
Human Diseases	Infectious disease: viral	hsa05162	Measles	27/1241	136/9376	1.49992889984358	JUN/CSNK2B/CCND2/CDK2/ADAR/CD209/FOS/TLR7/CD46/STAT3/BCL2L1/CDKN1B/PIK3CA/PIK3R2/MAVS/AKT1/IFNAR1/CCND1/CDK4/EIF3H/CDK6/AKT3/MAP3K7/IRF3/BBC3/CSNK2A2/TAB2	2.29368863140266
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	30/1241	155/9376	1.46229627511632	CANX/MRC1/TUBB4A/TUBB/CD14/COLEC12/TUBA1B/HLA-F/CD209/C1R/HLA-E/PIKFYVE/LAMP1/SEC61A1/M6PR/HLA-A/NCF4/FCGR1A/HLA-B/ATP6AP1/SCARB1/RAB5C/DYNC1LI2/STX7/DYNC1I2/RAB5B/RAC1/PIK3C3/VAMP3/TLR6	2.26667879917741
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/1241	59/9376	1.79275871017086	IRS1/ADCY5/ADCY6/ADRB3/ADCY9/PIK3CA/PIK3R2/AKT1/ADCY3/PRKACA/ADCY4/GNAI3/AKT3/GNAI1	2.38573241176537
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	41/1241	226/9376	1.3706331605257	JUN/PPP1R12A/ATP1B2/HTR1F/PTGER2/ADCY5/FOS/ATP2A2/EP300/ADCY6/GABBR1/PTCH1/CREB3L2/ADCY9/MAPK1/ROCK2/VIPR2/CREB3L1/ATP1A2/PIK3CA/PIK3R2/ROCK1/AKT1/CACNA1C/ATP2B4/ADCY3/RAC3/PRKACA/CALM3/ADCY4/CREBBP/PPP1CC/GNAI3/AKT3/MAP2K2/RHOA/RAC1/EDNRA/CACNA1D/PLCE1/GNAI1	2.20282854648929
NA	NA	hsa04517	IgSF CAM signaling	52/1241	299/9376	1.31394737764075	PLCG2/MYH11/TJP1/CADM1/LRRC4B/KIRREL1/TUBB4A/NFASC/TUBB/TRPC6/NCK2/ESAM/MTSS1/ACTN4/EPB41L2/TUBA1B/MYLK/PMP22/NLGN2/PTK2/NRP2/CD209/EPB41L1/BCAR1/VCL/CD84/PPFIA1/RAPGEF2/MAPK1/JAM3/ROBO2/MPDZ/PIK3CA/ABL1/PIK3R2/ITGA4/PTPN11/AKT1/CLMP/LMO7/RAPGEF6/PTPRD/MYH10/FGFR1/WASL/NECTIN3/AKT3/MYH9/MAP2K2/CADM3/RHOA/RAC1	2.15483507731213
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	22/1241	107/9376	1.55340507730425	ATF4/GCK/EP300/SIRT1/CREB3L2/CREB3L1/ITPR2/AKT1/PFKL/PRKACA/CALM3/PCK2/ITPR1/ACACA/PRKAG1/CREBBP/ATF2/PPP4R3B/AKT3/PFKP/CPT1B/PFKM	2.24859550107044
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	14/1241	60/9376	1.76287939833468	PLCG2/SHC2/PTK2/MAPK1/PIK3CA/PIK3R2/AKT1/HRAS/RAC3/PLA2G4B/AKT3/MAP2K2/RAC1/MAPKAPK3	2.31531199876576
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	65/1241	388/9376	1.26569028967328	COX4I2/WNT3A/NDUFA4L2/MT-ND1/WNT2/WNT6/LRP1/TUBB4A/TUBB/CSNK1E/CSNK2B/IRS1/TUBA1B/FZD7/LRP6/NDUFS1/ATF4/ATP5F1B/FZD2/ATP2A2/SLC39A1/SLC25A6/SDHA/MAPK1/MAP2K7/ATF6/WIPI2/APC/KLC1/PIK3CA/SLC39A14/PIK3R2/ITPR2/AXIN2/AKT1/CACNA1C/HRAS/RB1CC1/PSEN2/ULK1/CALM3/ITPR1/NDUFA10/DVL3/FZD1/ATG2B/SLC39A7/UQCRC1/MT-CO3/DVL2/NCSTN/PSMC1/AKT3/SLC25A5/ATP5F1A/TNFRSF1A/PSMC3/PIK3R4/MAP2K2/ADRM1/PIK3C3/CSNK2A2/MAPT/CACNA1D/FZD6	2.08762631953603
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	21/1241	103/9376	1.54038005679729	C1QA/JUN/C1QB/C1QC/GNAL/TGFB2/CCL3/TGFBR2/FOS/TGFBR1/MAPK1/PIK3CA/PIK3R2/AKT1/PPP2CB/PPP2R1A/GNAI3/AKT3/TNFRSF1A/TLR6/GNAI1	2.1537760604303
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	37/1241	205/9376	1.36362099801498	PLCG2/HES1/JUN/RBPJ/CCND2/NCOR2/HLA-F/CDK2/HLA-E/BCL2L11/SIN3A/STAT3/MAP2K7/CDKN1B/PIK3CA/PIK3R2/MAVS/RB1/AKT1/USP7/HLA-A/IFNAR1/CCND1/CDK4/HLA-B/POLK/HDAC1/CDK6/PSMC1/AKT3/PSMC3/MAP3K7/SAP30L/IRF3/ADRM1/RAC1/TAB2	2.05593930132381
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/1241	98/9376	1.54187702478252	PLCG2/CFL2/PLPP3/WASF2/MARCKS/MAPK1/PIK3CA/PIK3R2/CRKL/AKT1/DOCK1/FCGR1A/INPPL1/PLA2G4B/RPS6KB1/AKT3/SCIN/BIN1/RAC1/CRK	2.10610171452982
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	18/1241	86/9376	1.58132039053277	ATP1B2/VAMP2/ATF4/GCK/KCNMB2/ATF6B/ADCY5/ADCY6/CREB3L2/ADCY9/CREB3L1/ATP1A2/CACNA1C/ADCY3/PRKACA/ADCY4/ATF2/CACNA1D	2.11519141721617
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	21/1241	105/9376	1.51103948428687	ITGA1/ITGA11/TNNT2/TGFB2/SGCA/ITGA9/ADCY5/ATP2A2/ADCY6/ITGA3/ADCY9/ITGA4/TPM2/CACNA1C/ADCY3/PRKACA/ADCY4/ITGA10/TPM4/CACNA1D/SNTA1	2.05673607441619
Organismal Systems	Digestive system	hsa04970	Salivary secretion	19/1241	93/9376	1.54353495706723	GUCY1B1/ATP1B2/GUCY1A1/GUCY1A2/VAMP2/ADCY5/ADCY6/ADRB3/ADCY9/ATP1A2/ITPR2/PRH1/ATP2B4/ADCY3/PRKACA/CALM3/ADCY4/ITPR1/SLC4A2	2.05739428927998
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1241	75/9376	1.61177544990599	PTEN/CCND2/IGFBP3/CDK2/ADGRB1/MDM4/BCL2L1/SIVA1/ATM/CCND1/CDK4/TSC2/CCNG1/CDK6/BBC3/CCNG2	2.07754579146686
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	52/1241	308/9376	1.27555281141099	COX4I2/GPX3/NDUFA4L2/MT-ND1/CLTC/TUBB4A/TUBB/DNAH8/POLR2J3/TUBA1B/HTT/NDUFS1/ATP5F1B/EP300/SLC25A6/CREB3L2/SIN3A/SDHA/SP1/MAP2K7/AP2A2/WIPI2/AP2M1/CREB3L1/KLC1/POLR2E/HIP1/REST/RB1CC1/ULK1/DCTN1/TAF4/ITPR1/ACTR1A/NDUFA10/CLTA/AP2B1/ATG2B/CREBBP/UQCRC1/MT-CO3/HDAC1/PSMC1/SLC25A5/ATP5F1A/PSMC3/PIK3R4/BBC3/ADRM1/PIK3C3/POLR2C/TFAM	1.92051276995825
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	27/1241	144/9376	1.41659951651894	RBPJ/ATP2A2/SLC25A6/TRPC3/SP1/WIPI2/NOP56/PIK3CA/PIK3R2/ITPR2/AKT1/RB1CC1/ULK1/PUM2/ITPR1/ATG2B/ATXN2L/KAT5/PSMC1/AKT3/SLC25A5/PSMC3/PIK3R4/ADRM1/PIK3C3/OPA1/CIC	1.96763645401149
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	16/1241	78/9376	1.54978408644807	PLCG2/PTEN/ISYNA1/PIP4K2B/PIK3C2A/PIKFYVE/PIK3CA/INPP5A/INPPL1/IP6K1/SACM1L/PIK3C3/OCRL/PLCH2/PLCE1/MINPP1	1.90430911306104
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	20/1241	103/9376	1.46702862552123	COL3A1/COL6A1/COL6A2/COL1A2/COL5A1/COL1A1/COL16A1/DPP4/ATP1B2/COL21A1/COL8A2/COL4A5/COL14A1/SLC38A2/ATP1A2/ELN/COL5A2/COL6A6/COL27A1/COL13A1	1.86142153199525
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	20/1241	103/9376	1.46702862552123	COL3A1/LAMC1/COL1A2/COL1A1/CD14/ACTN4/GNAL/TGFB2/SERPINB6/PTK2/COL4A5/VCL/LAMB2/LAMA5/LAMC3/PIK3CA/PIK3R2/PRKACA/RAB5C/RAB5B	1.86142153199525
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	26/1241	142/9376	1.3833460067415	JUN/SDC2/MEF2C/THBD/PDGFA/PTK2/ACVR2B/FOS/MAP2K7/BMPR2/ACVR2A/PIK3CA/PIK3R2/SUMO3/GSTM3/AKT1/PDGFB/RAC3/CALM3/BMPR1A/AKT3/TNFRSF1A/MAP3K7/RHOA/RAC1/SDC1	1.79776504127458
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1241	49/9376	1.69606472726077	JUN/ATF4/ATF6B/ADCY5/CREB3L2/CREB3L1/FOSB/PRKACA/GNAI3/ATF2/GNAI1	1.90796071626206
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	40/1241	235/9376	1.28599105045691	COX4I2/NDUFA4L2/MT-ND1/KDM3A/RPS6KA2/NDUFS1/ATP5F1B/ADCY5/ADCY6/CREB3L2/SDHA/ADRB3/ADCY9/TSC1/ARID1B/CREB3L1/SMARCC2/SMARCE1/HRAS/ADCY3/SMARCA4/PRKACA/ADCY4/ARID1A/FRS2/NDUFA10/FGFR1/SOS1/PRKAG1/SMARCB1/UQCRC1/TSC2/SOS2/MT-CO3/SMARCC1/RPS6KB1/ATF2/ATP5F1A/KDM1A/CPT1B	1.7341324693448
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	22/1241	119/9376	1.39675918715593	JUN/ATF4/ATF6B/FOS/CREB3L2/JAG1/MAPK1/MAP2K7/CREB3L1/ITCH/PIK3CA/PIK3R2/AKT1/DAB2IP/BAG4/DNM1L/IL18R1/ATF2/AKT3/TNFRSF1A/MAP3K7/TAB2	1.70121064275533
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	14/1241	69/9376	1.53293860724754	PLCG2/MAPK1/MAP2K7/PIK3CA/PIK3R2/AKT1/HRAS/RAC3/SOS1/SOS2/PLA2G4B/AKT3/MAP2K2/RAC1	1.73536015423771
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	35/1241	205/9376	1.28991175487903	COX4I2/AGTR1/PDK4/NDUFA4L2/PTEN/COL3A1/MT-ND1/COL1A2/COL1A1/IRS1/TGFB2/NDUFS1/ATP5F1B/TGFBR2/ATP2A2/SLC25A6/TGFBR1/SDHA/SP1/CTSD/PIK3CA/PIK3R2/AKT1/NCF4/NDUFA10/GFPT1/UQCRC1/PPP1CC/MT-CO3/AKT3/SLC25A5/ATP5F1A/PDK3/RAC1/CPT1B	1.63918193400648
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1241	63/9376	1.55900899172454	WNT3A/WNT2/WNT6/FZD7/FZD2/PTCH1/APC/AXIN2/POLK/DVL3/FZD1/DVL2/FZD6	1.73874949627187
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/1241	76/9376	1.49115738580941	ATP1B2/MYLK/ADCY5/ADCY6/ADCY9/ATP1A2/ITPR2/ADCY3/PRKACA/CALM3/ADCY4/ITPR1/GNAI3/SLC4A2/GNAI1	1.67910846603947
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	34/1241	200/9376	1.28438356164384	MYH11/JUN/TJP1/ARHGEF12/TUBB4A/TUBB/NCK2/NCKAP1/TUBA1B/IL18/WASF2/FOS/MYO1B/MAPK1/MYO1C/ROCK2/CYTH3/ABL1/PTPN11/ROCK1/BAIAP2L1/CYFIP1/MYH10/WASL/TNFRSF1A/LPAR5/MYH9/MAP3K7/RHOA/WIPF2/CLDN12/RAC1/TAB2/GNA12	1.58776247899049
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6/1241	23/9376	1.97092106646113	ATP1B2/SLC4A4/GLS/ATP1A2/PCK2/AQP1	1.82081207744315
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	52/1241	323/9376	1.21631661273865	PLCG2/WNT3A/PTEN/PDGFRB/TNXB/NOTCH3/DICER1/IRS1/TGFB2/CCND2/IGF2BP1/PDGFA/BMF/GLS/EP300/SIRT1/BCL2L11/MDM4/HDAC5/MARCKS/NOTCH2/STAT3/MAPK1/CDKN1B/APC/BMPR2/DNMT3B/PIK3CA/ABL1/FSCN1/PIK3R2/CRKL/MMP16/ROCK1/HRAS/PDGFB/ATM/ZEB2/ABCC1/CCND1/SOS1/CREBBP/UBE2I/SOS2/CCNG1/HDAC1/CDK6/STMN1/MAP2K2/RHOA/DNMT3A/CRK	1.54521040918355
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	11/1241	52/9376	1.59821483914957	BMP6/HSD17B2/IGF1R/ADCY5/ADCY6/ADCY9/ADCY3/PRKACA/ADCY4/SCARB1/PLA2G4B	1.68946994993615
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	20/1241	109/9376	1.38627475622648	SPP1/JUN/CD14/CCL3/CCL4/FOS/TLR7/MAPK1/MAP2K7/PIK3CA/PIK3R2/AKT1/IFNAR1/AKT3/MAP3K7/MAP2K2/IRF3/RAC1/TAB2/TLR6	1.58428293731325
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	17/1241	90/9376	1.42709284627093	PTEN/JUN/CSNK2B/FOS/STAT3/MAPK1/PIK3CA/PIK3R2/PTPN11/AKT1/MAP3K3/HRAS/RPS6KB1/AKT3/MAP2K2/CSNK2A2/CD4	1.59009093791518
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	25/1241	142/9376	1.33014039109759	PLCG2/JUN/CSF1R/TGFB2/TGFBR2/FOS/ATP2A2/TGFBR1/MAPK1/MAP2K7/FOSB/PIK3CA/PIK3R2/ITPR2/AKT1/LILRB5/IFNAR1/NCF4/FCGR1A/ITPR1/AKT3/TNFRSF1A/MAP3K7/RAC1/TAB2	1.54824843193996
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	13/1241	65/9376	1.51103948428687	LIPG/DGKG/DGKD/PLPP3/DGKH/AGPAT1/ABHD16A/ALDH3A2/MBOAT1/DGKE/AGPAT3/AGPAT5/GPAT4	1.61475159241522
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/1241	91/9376	1.41141050730092	PDE8B/KCNJ5/GNG12/ADCY5/ADCY6/GABBR1/GABRE/ADCY9/GABRA3/ADCY3/PRKACA/ADCY4/GNB4/GNAI3/PDE2A/GNAI1/GRK5	1.54027359975321
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/1241	137/9376	1.32353823441185	JUN/TUBA1B/ATF4/FOS/SEPTIN4/BCL2L11/CTSO/NOL3/BCL2L1/MAPK1/CTSD/PIK3CA/PIK3R2/ITPR2/AKT1/PTPN13/HRAS/ATM/DAB2IP/ITPR1/AKT3/TNFRSF1A/MAP2K2/BBC3	1.48993101776614
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	13/1241	67/9376	1.4659338280395	RPS6KA2/ATF4/EP300/MAPK1/ITPR2/CACNA1C/HRAS/PRKACA/CALM3/ITPR1/CREBBP/PPP1CC/MAP2K2	1.49486811637175
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	30/1241	180/9376	1.25919957023905	SRSF1/HLA-F/HLA-E/SRSF7/BCL2L1/TSC1/EIF4EBP1/PIK3CA/SRSF3/PIK3R2/MAVS/PTPN11/AKT1/SRSF4/HLA-A/IFNAR1/HLA-B/POU2F1/SRSF8/SRSF6/PML/HCFC1/TSC2/PPP1CC/AKT3/TNFRSF1A/MAP3K7/IRF3/HCFC2/TAB2	1.3713989060302
NA	NA	hsa04981	Folate transport and metabolism	7/1241	31/9376	1.70601232096904	FOLR2/SLCO2B1/MTHFR/SHMT1/MTR/ABCC1/ABCC5	1.53778713948339
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1241	37/9376	1.63355619922904	TPR/RXRB/MAPK1/NCOA4/HRAS/CCND1/POLK/MAP2K2	1.50809454627027
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	29/1241	174/9376	1.25919957023905	CANX/ATF4/ATF6B/SEL1L/RAD23A/RAD23B/MAP2K7/ATF6/TRAM1/STT3B/DNAJB2/MAN1A1/BCAP29/SEC61A1/RNF5/MBTPS1/UBQLN2/NSFL1C/PRKCSH/GANAB/SEC63/DNAJC10/UBXN6/EDEM3/WFS1/UBE2G2/SEC31A/UBXN1/SYVN1	1.34790888828245
Genetic Information Processing	Transcription	hsa03040	Spliceosome	39/1241	243/9376	1.21256254911909	PRPF8/DDX39B/SRSF1/SF1/SNRNP200/SF3B2/HNRNPU/RBMX/CASC3/PRPF31/SF3B1/DDX42/WBP11/SRSF7/SNRNP70/HNRNPA1/U2AF1/TRA2B/SNRPD3/HNRNPM/SRSF3/SYF2/CDC5L/PUF60/SRSF4/SF3B3/ACIN1/SRSF8/SRSF6/U2SURP/SF3B4/THOC2/PRPF19/SF3A2/RBM17/SLU7/DHX38/SNRPC/DDX46	1.31122103566896
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/1241	32/9376	1.65269943593876	ATG9A/WIPI2/PPP2CB/ATG2B/PIK3R4/PIK3C3/ATG16L1	1.44449007429481
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1241	32/9376	1.65269943593876	NGFR/SEPTIN4/BCL2L11/BCL2L1/TNFRSF1A/BBC3/BIRC6	1.44449007429481
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1241	122/9376	1.30048480205017	JUN/NCK2/FOS/MAPK1/MAP2K7/PIK3CA/PIK3R2/PTPN11/AKT1/HRAS/PPP2CB/CDK4/SOS1/PPP2R1A/SOS2/AKT3/MAP3K7/MAP2K2/RHOA/CD4/PPP2R5A	1.30475938439692
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	16/1241	91/9376	1.32838635981263	PLCG2/JUN/FOS/MAPK1/PIK3CA/PIK3R2/AKT1/LILRB5/HRAS/RAC3/INPPL1/SOS1/SOS2/AKT3/MAP2K2/RAC1	1.229440744858
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/1241	86/9376	1.31776699211064	ITGA1/ITGA11/GJA1/SGCA/ITGA9/ATP2A2/ITGA3/CTNNA3/CTNNA1/ITGA4/CACNA1C/DSP/ITGA10/CACNA1D/SNTA1	1.15622645503803
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	71/1241	480/9376	1.11753961858716	COX4I2/GPX3/WNT3A/NDUFA4L2/MT-ND1/WNT2/WNT6/TUBB4A/TUBB/CSNK1E/DNAH8/CSNK2B/TUBA1B/FZD7/HTT/LRP6/NDUFS1/ATF4/ATP5F1B/GPR37/SMCR8/FZD2/ATP2A2/SLC25A6/TRPC3/TARDBP/SDHA/BCL2L1/MAPK1/MAP2K7/ATF6/WIPI2/APC/KLC1/ITPR2/AXIN2/HIP1/CACNA1C/HRAS/RB1CC1/PSEN2/ULK1/DCTN1/CALM3/ITPR1/ACTR1A/NDUFA10/DVL3/FZD1/ATG2B/UQCRC1/ATXN2L/UBE2G2/MT-CO3/SIGMAR1/DVL2/MFN2/PSMC1/SLC25A5/ATP5F1A/TNFRSF1A/PSMC3/PIK3R4/MAP2K2/ADRM1/RAC1/PIK3C3/CSNK2A2/MAPT/CACNA1D/FZD6	1.03252424677422
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1241	48/9376	1.41659951651894	ATP1B2/TAS1R3/ATP1A2/PIK3CA/PIK3R2/AKT1/AKT3/CACNA1D/SLC37A4	1.13015461258126
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1241	75/9376	1.30956755304862	ATP7B/BCL2L1/MAPK1/PIK3CA/PIK3R2/GSTM3/TOP2B/AKT1/ATM/ATP7A/MSH6/AKT3/BBC3	1.05126932947322
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	17/1241	102/9376	1.25919957023905	ATP1B2/PLA2G5/PLA2G2A/SLC4A4/ADCY5/ATP2A2/ADCY6/ADCY9/ATP1A2/ITPR2/ATP2B4/ADCY3/ADCY4/ITPR1/SLC4A2/RHOA/RAC1	1.02800107199358
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	35/1241	227/9376	1.16489828083789	HGF/COX4I2/NDUFA4L2/PTEN/JUN/MT-ND1/NDUFS1/CBR1/ATP5F1B/PTK2/FOS/SLC25A6/SDHA/MAPK1/MAP2K7/PIK3CA/ABL1/PIK3R2/GSTM3/PTPN11/AKT1/HRAS/AHR/PRKD3/NDUFA10/EPHX1/SOS1/UQCRC1/SOS2/MT-CO3/AKT3/SLC25A5/ATP5F1A/MAP2K2/RAC1	0.982279302119353
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	19/1241	116/9376	1.23748923282114	GNG12/GLS/DLGAP1/ADCY5/ADCY6/SLC38A2/ADCY9/MAPK1/ITPR2/CACNA1C/ADCY3/PRKACA/ADCY4/ITPR1/GNB4/GNAI3/PLA2G4B/CACNA1D/GNAI1	1.00521781352391
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1241	30/9376	1.51103948428687	FOLR2/MTHFR/SHMT1/MTR/ABCC1/ABCC5	1.09495165794182
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	18/1241	110/9376	1.23630503259834	RPS6KA2/IGF1R/CDK2/ADCY5/ADCY6/ADCY9/MAPK1/PIK3CA/PIK3R2/AKT1/ADCY3/ANAPC13/PRKACA/ADCY4/GNAI3/AKT3/CDC16/GNAI1	0.973679252212968
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	22/1241	138/9376	1.20445176283736	RPS6KA2/IGF1R/CDK2/SLK/ADCY5/ADCY6/ADCY9/MAPK1/SMC3/ITPR2/ADCY3/ANAPC13/PRKACA/CALM3/PPP2CB/ADCY4/ITPR1/PPP2R1A/PPP1CC/SMC1A/CDC16/PPP2R5A	0.945005147332466
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1241	12/9376	1.88879935535858	NGFR/CD209/CD46	1.20325147233545
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/1241	70/9376	1.29517670081731	IRS1/RXRB/STAT3/PTPN11/AKT1/PCK2/PRKAG1/AKT3/TNFRSF1A/APPL1/STK11/CPT1B	0.968149266054315
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/1241	70/9376	1.29517670081731	EIF4G2/SGCA/HLA-F/HLA-E/EIF4G1/ABL1/HLA-A/RAC3/CCND1/HLA-B/RAC1/SNTA1	0.968149266054315
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/1241	216/9376	1.15426627271913	JUN/HSPA2/CD14/CCL3/ATF4/IL18/RXRB/PTK2/FOS/STAT3/BCL2L1/MAPK1/MAP2K7/ROCK2/ATF6/PIK3CA/PIK3R2/AKT1/HRAS/CALM3/NCF4/MIB1/ITPR1/POU2F1/AKT3/TNFRSF1A/MAP3K7/IRF3/RHOA/RAC1/TAB2/MIB2/TLR6	0.8958656308612
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	8/1241	44/9376	1.3736722584426	GTF2I/TAF15/GTF2H1/TAF1/TAF7/TAF9/GTF2H2/TAF4	0.970336974426808
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/1241	105/9376	1.2232224396608	PLCG2/JUN/ARHGEF12/NFATC4/CD209/EGR2/MAPK1/PIK3CA/PIK3R2/ITPR2/PTPN11/AKT1/HRAS/CALM3/ITPR1/AKT3/RHOA	0.898383898673148
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	26/1241	168/9376	1.16925674379341	PDGFRB/PRLR/FHL1/IL6ST/CCND2/PDGFA/EP300/SOCS7/CISH/STAT3/BCL2L1/LIFR/PIK3CA/PIK3R2/PTPN11/AKT1/HRAS/PDGFB/IFNAR1/CCND1/SOS1/STAT6/CREBBP/SOS2/AKT3/EPOR	0.864591013931496
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	16/1241	99/9376	1.22104200750454	ITGA1/ITGA11/TNNT2/TGFB2/SGCA/ITGA9/ATP2A2/ITGA3/ITGA4/TPM2/CACNA1C/PRKAG1/ITGA10/TPM4/CACNA1D/SNTA1	0.863537864882065
Human Diseases	Substance dependence	hsa05034	Alcoholism	29/1241	191/9376	1.14712421581987	SHC2/ATF4/ATF6B/GNG12/ADCY5/H2AZ2/CREB3L2/HDAC5/HDAC9/SLC29A1/MAPK1/H2AZ1/CREB3L1/FOSB/MACROH2A1/HRAS/PRKACA/CALM3/HDAC6/SOS1/GNB4/MACROH2A2/SOS2/PPP1CC/GNAI3/HDAC1/ATF2/SLC29A3/GNAI1	0.802331816779268
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1241	13/9376	1.74350709725408	RAD50/XRCC6/XRCC5	1.04771227774055
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	24/1241	156/9376	1.16233806483605	CDK2/STAT3/MAPK1/EIF3E/PIK3CA/PIK3R2/MAVS/RB1/AKT1/HRAS/IFNAR1/PPP2CB/CCND1/CDK4/SCARB1/SOS1/PPP2R1A/SOS2/CDK6/AKT3/TNFRSF1A/MAP2K2/IRF3/CLDN12	0.798564414968469
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	22/1241	142/9376	1.17052354416588	HERC2/UBA2/CUL4B/UBE3A/KLHL9/ITCH/DET1/TRIP12/ANAPC13/HUWE1/PML/UBE2I/UBE2G2/PRPF19/CDC34/UBE2W/CUL5/WWP1/UBA6/CDC16/SYVN1/BIRC6	0.799698603936125
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	22/1241	144/9376	1.15426627271913	C1QA/C2/C1QB/CD14/C1QC/SIRT1/C3AR1/MAP2K7/ACADVL/TRA2B/ADH1B/AKT1/CCND1/ALDH3A2/ACACA/PRKAG1/AKT3/TNFRSF1A/MAP3K7/IRF3/CPT1B/TAB2	0.728613283959121
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/1241	67/9376	1.24040554680265	ACSS1/GCK/ENO2/ADH1B/PFKL/PCK2/ALDH3A2/GPI/PFKP/PFKM/MINPP1	0.771299625155646
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1241	20/9376	1.51103948428687	UGP2/UAP1L1/CYB5R3/NPL	0.893546375999953
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	35/1241	238/9376	1.11105844432858	AGTR1/PLCG2/RPS4Y1/C1QA/F13A1/JUN/C2/C1QB/IL6ST/C1QC/RPL4/ADAR/C1R/FOS/TLR7/RPS9/C3AR1/RPS10/STAT3/MAPK1/RPL35/RPL36A/PIK3CA/HBEGF/PIK3R2/MAVS/IFNAR1/RPL23A/RPS2/RPL13A/RPL15/TNFRSF1A/MAP3K7/IRF3/TAB2	0.677808854176398
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1241	47/9376	1.28599105045691	IRS1/GCK/MAPK1/MAFA/PIK3CA/PIK3R2/CACNA1C/CACNA1D	0.767673547016352
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	40/1241	275/9376	1.09893780675408	COX4I2/NDUFA4L2/C1QA/LAMC1/MT-ND1/C1QB/TUBB4A/TUBB/C1QC/CSNK2B/TUBA1B/NDUFS1/ATF4/ATF6B/ATP5F1B/SLC25A6/CREB3L2/SDHA/MAPK1/CREB3L1/KLC1/PIK3CA/PIK3R2/ITPR2/CACNA1C/PRKACA/NCF4/ITPR1/NDUFA10/UQCRC1/MT-CO3/ATF2/PSMC1/SLC25A5/ATP5F1A/PSMC3/ADRM1/RAC1/CSNK2A2/CACNA1D	0.650394438210097
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	37/1241	254/9376	1.10056025430343	HGF/AGTR1/PLCG2/EDNRB/PDGFD/PDGFRB/CYSLTR2/NFATC4/MCOLN2/GNAL/PDGFA/MYLK/TPCN1/ATP2A2/SLC25A6/ADRB3/ADCY9/ITPR2/CACNA1C/ATP2B4/TBXA2R/CACNA1H/ADCY3/PDGFB/PRKACA/CALM3/ADCY4/ITPR1/FGFR1/FGF2/SLC25A5/GDNF/PDGFC/EDNRA/CACNA1D/MCOLN3/PLCE1	0.634586658989335
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1241	41/9376	1.28991175487903	MAPK1/HBEGF/RB1/HRAS/CCND1/CDK4/MAP2K2	0.726596568222138
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1241	21/9376	1.43908522313035	ENPP1/PANK3/ALDH3A2/AASDHPPT	0.786736543645326
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/1241	63/9376	1.19923768594196	POLR2J3/GTF2H1/RAD23A/CUL4B/RAD23B/ERCC5/POLR2E/POLR2M/GTF2H2/POLR2C	0.619711724137443
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	22/1241	149/9376	1.11553250517822	NDUFA4L2/MT-ND1/NDUFS1/KCNJ5/GNG12/ADCY5/ADCY6/GABRE/ADCY9/MAPK1/GABRA3/ITPR2/CACNA1C/ADCY3/PRKACA/ADCY4/ITPR1/NDUFA10/GNB4/GNAI3/CACNA1D/GNAI1	0.555213240938474
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/1241	99/9376	1.1447268820355	PLCG2/PTGER2/ADCY5/ADCY6/ADCY9/PIK3CA/PIK3R2/ITPR2/ADCY3/PRKACA/CALM3/ADCY4/ITPR1/PPP1CC/PLA2G4B	0.565399962273741
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	23/1241	157/9376	1.10681236110184	COX4I2/NDUFA4L2/JUN/IRS1/MLXIP/NDUFS1/ATF4/FOS/BCL2L11/SDHA/GSK3A/ITCH/PIK3CA/PIK3R2/AKT1/MAP3K11/NDUFA10/PRKAG1/UQCRC1/MT-CO3/AKT3/TNFRSF1A/RAC1	0.527135402327194
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1241	50/9376	1.20883158742949	HGF/HBA2/HBA1/SDC2/LRP1/TGFB2/IL18/SDC1	0.578264107432434
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1241	23/9376	1.31394737764075	AGTR1/LNPEP/CTSA/ENPEP	0.588759680509798
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1241	37/9376	1.22516714942178	UGP2/PGM3/GCK/UAP1L1/GFPT1/GPI	0.535979839602911
NA	NA	hsa04081	Hormone signaling	31/1241	219/9376	1.06945716924413	AGTR1/PRLR/IRS1/IGF1R/GNG12/ADCY5/ADCY6/SLC40A1/SMAD4/ADRB3/ADCY9/PTH1R/STAT3/VIPR2/PIK3CA/PIK3R2/THRA/ADCY3/PRKACA/ADCY4/SMAD5/GPER1/GNB4/GNAI3/BMPR1A/EPOR/APPL1/RHOA/STK11/GNA12/GNAI1	0.406214367602076
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/1241	88/9376	1.11610870998462	C1QA/F13A1/C2/C1QB/THBD/VSIG4/C1QC/TFPI/SERPING1/C1R/CD46/C3AR1/C4BPB	0.427403213269719
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1241	52/9376	1.16233806483605	LIPG/PLTP/LRP1/ANGPTL4/MYLIP/SORT1/SCARB1/CYP27A1	0.45847288352324
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1241	38/9376	1.19292590864753	UGP2/PGM3/GCK/UAP1L1/GFPT1/GPI	0.46542335045105
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1241	38/9376	1.19292590864753	ATP1B2/IRS1/MAPK1/ATP1A2/PIK3CA/PIK3R2	0.46542335045105
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1241	31/9376	1.2185802292636	PFKL/GPI/PFKP/SHPK/PFKM	0.476096316627363
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/1241	31/9376	1.2185802292636	BAG6/SEC61A1/OXA1L/SRP68/SEC63	0.476096316627363
Organismal Systems	Digestive system	hsa04976	Bile secretion	13/1241	90/9376	1.09130629420718	ATP1B2/SLC4A4/ADCY5/ADCY6/ADCY9/ATP1A2/ADCY3/PRKACA/ADCY4/SCARB1/EPHX1/AQP1/SLC4A2	0.339938522176407
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1241	39/9376	1.16233806483605	AHCYL1/MAT2A/MTHFR/SHMT1/MTR/MAT2B	0.396772660005699
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	37/1241	268/9376	1.04306830072041	COX4I2/NDUFA4L2/MT-ND1/TUBB4A/TUBB/GNAL/TUBA1B/NDUFS1/ATF4/ATP5F1B/GPR37/ADCY5/SLC39A1/SLC25A6/SDHA/BCL2L1/ATF6/KLC1/SLC39A14/ITPR2/PRKACA/CALM3/ITPR1/NDUFA10/SLC39A7/UQCRC1/UBE2G2/GNAI3/MT-CO3/MFN2/PSMC1/SLC25A5/ATP5F1A/PSMC3/ADRM1/MAPT/GNAI1	0.279387115045482
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1241	32/9376	1.18049959709911	UGP2/GCK/PFKL/PFKP/PFKM	0.399463921780294
Cellular Processes	Cell motility	hsa04814	Motor proteins	27/1241	194/9376	1.05149654834395	MYH11/TUBB4A/TUBB/TNNT2/DNAH8/TUBA1B/DYNLRB1/STARD9/MYO1B/TNNT3/MYO1C/HOOK3/CAPZB/KLC1/TPM2/KIF1C/DCTN1/MYO15B/MYO9A/ACTR1A/MYH10/DYNC1LI2/TPM4/MYO7A/MYH9/DYNC1I2/ACTG2	0.283076027025728
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1241	18/9376	1.25919957023905	NEU1/MAN2C1/MAN2B1	0.429904270809548
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1241	18/9376	1.25919957023905	MTR/HCFC1/MTRR	0.429904270809548
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1241	55/9376	1.09893780675408	NEU1/PLPP3/SGPP1/ASAH1/CERS2/KDSR/SAMD8/SPTLC1	0.287412147578595
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	4/1241	26/9376	1.16233806483605	HES1/GCK/MAFA/HHEX	0.323738226680904
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	22/1241	160/9376	1.03883964544722	SDC2/CADM1/LRRC4B/SIGLEC1/NFASC/ESAM/HLA-F/ITGA9/NLGN2/GLG1/NTNG1/HLA-E/JAM3/ITGA4/HLA-A/HLA-B/PTPRD/NECTIN3/CADM3/CLDN12/SDC1/CD4	0.193533773865204
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/1241	34/9376	1.11105844432858	POLR2J3/POLR2E/POLR2M/POLR3E/POLR2C	0.25337505914509
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/1241	57/9376	1.06037858546447	HACD4/ELOVL2/ACADVL/HACD2/FADS1/ACACA/PPT2/CPT1B	0.178578206336284
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1241	27/9376	1.11928850687916	HACD4/ELOVL2/HACD2/FADS1	0.24243239677728
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/1241	133/9376	1.02250792169788	PLCG2/SHC2/HLA-E/MAPK1/SH3BP2/PIK3CA/PIK3R2/PTPN11/HRAS/HLA-A/IFNAR1/RAC3/HLA-B/SOS1/SOS2/MICA/MAP2K2/RAC1	0.102105112909113
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1241	28/9376	1.07931391734776	HACD4/ELOVL2/HACD2/PPT2	0.164157910126281
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1241	51/9376	1.03698788137334	PLA2G5/PLA2G2A/PLPP3/PLD3/ENPP2/LPCAT2/PLA2G4B	0.103445802772479
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/1241	51/9376	1.03698788137334	PLCG2/TJP1/ADCY9/SEC61A1/ADCY3/PRKACA/ATP6AP1	0.103445802772479
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/1241	112/9376	1.01185679751353	LAMC1/TGFB2/LAMB2/LAMA5/STAT3/BCL2L1/MAPK1/LAMC3/AKT1/GNAI3/AKT3/TNFRSF1A/MAP3K7/TAB2/GNAI1	0.0493026078338542
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/1241	173/9376	1.00444821209821	XPO1/IL18/ADAR/EP300/SLC25A6/TLR7/MAPK1/PIK3CA/PIK3R2/MAVS/AKT1/IFNAR1/CDK4/KPNA1/PML/CREBBP/CDK6/AKT3/SLC25A5/TNFRSF1A/MAP2K2/IRF3/RAB11B	0.0230641034756895
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/1241	105/9376	1.00735965619124	PLCG2/CD14/CSNK2B/CCL4/BCL2L1/ATM/UBE2I/TNFRSF1A/LTBR/TNFSF13B/MAP3K7/CSNK2A2/TAB2/CCL13	0.0296197668658695
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/1241	128/9376	1.00342465753425	IMPDH2/GUCY1B1/PDE8B/GUCY1A1/GUCY1A2/NME4/ADCY5/ADCY6/ADCY9/ENPP1/PDE5A/ADSL/ADCY3/ADCY4/ENTPD4/PDE2A/GMPR2	0.0152367019812947
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1241	45/9376	1.00735965619124	ABCC9/ABCA5/ABCA8/ABCC1/ABCC5/ABCB10	0.019328245761223
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/1241	115/9376	0.985460533230564	HTR1F/KCNJ5/GNG12/ADCY5/MAPK1/ITPR2/CACNA1C/HRAS/PRKACA/ITPR1/GNB4/GNAI3/PLA2G4B/CACNA1D/GNAI1	-0.0612718802294912
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1241	61/9376	0.990845563466797	ATP1B2/ATP7B/CYBRD1/SLC40A1/ATP1A2/ATP2B4/MT1E/ATP7A	-0.0280154663567203
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	12/1241	93/9376	0.974864183410881	JUN/MAF/NOTCH3/RBPJ/FOS/MAML1/JAG1/NOTCH2/MAPK1/STAT6/DLL1/CD4	-0.0951443597774821
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1241	54/9376	0.979377443519265	AHCYL1/MAT2A/DNMT3B/MTR/MAT2B/DNMT3A/MTAP	-0.0593577708181695
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/1241	78/9376	0.968615054030042	JUN/EEF1A1/TGFB2/FOS/MAPK1/ITGA4/NCF4/FCGR1A/MAP3K7/TAB2	-0.108709291696032
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/1241	71/9376	0.957701081590267	PLCG2/JUN/TJP1/JAM3/HBEGF/NOD1/PTPN11/ATP6AP1/RAC1	-0.139731074430109
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/1241	79/9376	0.956354103979029	CLTC/VAMP2/AP2A2/STXBP1/AP2M1/SLC6A1/CLTA/AP2B1/NSF/DNM1	-0.152152220278003
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/1241	87/9376	0.955254846388248	COX4I2/ATP1B2/TNNT2/ATP2A2/ATP1A2/TPM2/CACNA1C/UQCRC1/MT-CO3/TPM4/CACNA1D	-0.163762288423267
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/1241	56/9376	0.944399677679291	CSNK1E/CCND2/PTCH1/PRKACA/CCND1/CSNK1G1/SPOP	-0.16298818248681
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1241	49/9376	0.925126214869509	OGT/GALNT18/GALNT1/COLGALT1/POMT2/FUT11	-0.205234132849981
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/1241	33/9376	0.915781505628403	VAMP2/VAMP7/STX7/VAMP3	-0.189284049603671
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/1241	83/9376	0.910264749570401	IL18/ADAR/CCL4/G3BP1/ZCCHC3/POLR2E/MAVS/GSDMD/POLR3E/IRF3	-0.32071325315685
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/1241	75/9376	0.906623690572119	MAT2A/ENO2/GPT2/SHMT1/MTR/MAT2B/PFKL/PFKP/PFKM	-0.3170992865183
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/1241	34/9376	0.888846755462862	CSNK1E/CLOCK/PRKAG1/FBXL3	-0.253591341739324
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1241	17/9376	0.888846755462862	AMACR/CYP27A1	-0.179153225444785
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1241	17/9376	0.888846755462862	INMT/MTR	-0.179153225444785
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/1241	100/9376	0.906623690572119	CSF1R/ACKR3/IL6ST/CCL3/IL18/CCL4/CCL28/CCR1/IL18R1/TNFRSF1A/LTBR/CCL13	-0.366647801624612
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1241	26/9376	0.871753548627038	PLA2G5/PLA2G2A/PLA2G4B	-0.255751962964029
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1241	26/9376	0.871753548627038	ABCC1/SCARB1/SLC19A3	-0.255751962964029
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	46/1241	368/9376	0.944399677679291	COX4I2/GPX3/NDUFA4L2/MT-ND1/TUBB4A/TUBB/TPR/DNAH8/TUBA1B/NDUFS1/ATF4/ATP5F1B/ANXA11/SETX/SMCR8/TARDBP/SDHA/SRSF7/BCL2L1/ATF6/WIPI2/HNRNPA1/KLC1/SRSF3/RB1CC1/ULK1/DCTN1/UBQLN2/POM121C/ACTR1A/NDUFA10/ANXA7/HDAC6/ATG2B/UQCRC1/ATXN2L/MT-CO3/SIGMAR1/PSMC1/ATP5F1A/TNFRSF1A/PSMC3/PIK3R4/ADRM1/RAC1/PIK3C3	-0.424991045998884
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1241	43/9376	0.878511328073759	PLA2G5/PLA2G2A/PLPP3/AGPAT1/SCARB1	-0.311854582215916
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	22/1241	181/9376	0.918311288793123	ARHGEF12/MRC1/CD14/TGFB2/IL18/CD209/EP300/MAPK1/CTSD/AKT1/LAMP1/CALM3/FCGR1A/ATP6AP1/RAB5C/CREBBP/AKT3/TNFRSF1A/RHOA/RAB5B/PIK3C3/TLR6	-0.433429248900599
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/1241	44/9376	0.858545161526628	HLA-F/HLA-E/HLA-A/HLA-B/ICA1	-0.367324190868098
Organismal Systems	Sensory system	hsa04742	Taste transduction	10/1241	86/9376	0.878511328073759	SCN9A/TAS1R3/HTR1F/ADCY6/GABBR1/GABRA3/CACNA1C/PRKACA/ADCY4/P2RY1	-0.442048481925548
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1241	36/9376	0.83946638015937	UGP2/GCK/ENPP1/GPI	-0.376909046305951
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1241	36/9376	0.83946638015937	MCM6/RNASEH2A/SSBP1/MCM7	-0.376909046305951
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1241	54/9376	0.83946638015937	HES1/TOP3A/FAN1/POLK/USP1/REV1	-0.46206287877125
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1241	37/9376	0.816778099614522	GLS/GPT2/ADSL/GFPT1	-0.436134867064445
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1241	37/9376	0.816778099614522	HBA2/HBA1/IL18/APOL1	-0.436134867064445
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1241	63/9376	0.83946638015937	PLA2G5/PLA2G2A/HPGDS/CBR1/PTGES3/PLA2G4B/PRXL2B	-0.499326047996986
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	23/1241	195/9376	0.891125849707639	PLCG2/SLC25A6/TLR7/H2AZ2/HDAC5/HDAC9/MAPK1/H2AZ1/PIK3CA/PIK3R2/AKT1/MACROH2A1/NCF4/FCGR1A/GSDMD/HDAC6/MACROH2A2/HDAC1/AKT3/SLC25A5/MAP3K7/MAP2K2/RAC1	-0.600053317107689
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	22/1241	187/9376	0.888846755462862	TXNIP/JUN/IL18/PKN2/BCL2L1/MAPK1/MAVS/ITPR2/NOD1/IFNAR1/ITPR1/GSDMD/DNM1L/MFN2/RNF31/PKN1/MAP3K7/IRF3/RHOA/TAB2/TRPM2/ATG16L1	-0.599655155690448
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1241	38/9376	0.79528393909835	SIRT1/NAPRT/ENPP1/NADK2	-0.493866456941574
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/1241	47/9376	0.803744406535567	ACSS1/ADH1B/PCK2/ALDH3A2/ACACA	-0.526800497134236
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1241	39/9376	0.774892043224034	HLA-F/HLA-E/HLA-A/HLA-B	-0.5501894019043
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1241	30/9376	0.755519742143433	PLA2G5/PLA2G2A/PLA2G4B	-0.523822663228551
NA	NA	hsa03272	Virion - Hepatitis viruses	5/1241	48/9376	0.786999731399409	DPP4/LAMP1/IST1/SCARB1/CLDN12	-0.577828889604731
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1241	21/9376	0.719542611565174	DSEL/CHSY1	-0.502513099493462
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/1241	66/9376	0.801308817424853	JUN/MAF/TGFB2/IL18/STAT3/STAT6/IL18R1	-0.632657225185869
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/1241	109/9376	0.831764853735889	JUN/IL6ST/RXRB/TGFBR2/FOS/TGFBR1/SMAD4/STAT3/MAPK1/AHR/STAT6/CD4	-0.690006445894579
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/1241	41/9376	0.737092431359447	RAD50/TOP3A/ATM/SSBP1	-0.658916839069049
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1241	32/9376	0.708299758259468	ACSS1/BCKDHA/ACACA	-0.645562230734225
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1241	23/9376	0.656973688820376	GLS/GPT2	-0.643292716423551
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1241	23/9376	0.656973688820376	MSH6/SSBP1	-0.643292716423551
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/1241	43/9376	0.702809062459007	ACADVL/ADH1B/ALDH3A2/CPT1B	-0.762872407737499
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/1241	44/9376	0.686836129221302	MGAT4B/STT3B/MAN1A1/ALG9	-0.8132112459664
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1241	35/9376	0.647588350408657	PFKL/PFKP/PFKM	-0.815793691850634
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1241	14/9376	0.539656958673881	B3GNT2	-0.67321538503422
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/1241	45/9376	0.671573104127496	HLA-F/HLA-E/HLA-A/HLA-B	-0.862528845514824
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/1241	82/9376	0.737092431359447	HSPA2/CANX/HLA-F/LGMN/HLA-E/HLA-A/HLA-B/CD4	-0.933902270554458
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/1241	100/9376	0.755519742143433	ITGA1/CSF1R/CD14/ITGA3/GP1BB/ITGA4/KIT/FCGR1A/EPOR/CD4	-0.959966715679213
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1241	56/9376	0.674571198342351	MGAT4B/STT3B/MAN1A1/GANAB/ALG9	-0.953970169544953
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/1241	56/9376	0.674571198342351	CD14/EEF1A1/HSF1/IL18/EEF1G	-0.953970169544953
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1241	15/9376	0.503679828095622	ST6GALNAC6	-0.751344624812191
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/1241	76/9376	0.695873446711056	PLTP/ANGPTL4/RXRB/PCK2/ILK/CPT1B/CYP27A1	-1.03971045764347
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1241	16/9376	0.472199838839645	AOC3	-0.825247725002288
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1241	28/9376	0.539656958673881	MOCS1/CBR1	-0.952782993606673
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1241	28/9376	0.539656958673881	SLC12A7/SLC4A1	-0.952782993606673
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/1241	59/9376	0.640270967918163	GPX3/HPGDS/GSTM3/LANCL1/LAP3	-1.082570522758
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/1241	50/9376	0.604415793714746	GATM/P4HA1/ALDH3A2/LAP3	-1.0953905526344
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1241	50/9376	0.604415793714746	CCL28/ITGA4/LTBR/TNFSF13B	-1.0953905526344
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/1241	30/9376	0.503679828095622	SDHA/PCK2	-1.06341410361867
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/1241	41/9376	0.552819323519585	GATM/AOC3/SHMT1	-1.12075464149944
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1241	18/9376	0.419733190079685	ACACA	-0.962421270852047
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/1241	42/9376	0.539656958673881	SLC40A1/NCOA4/SLC39A14	-1.16779088162132
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/1241	31/9376	0.48743209170544	AOC3/ALDH3A2	-1.11643991765667
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/1241	31/9376	0.48743209170544	ACSS1/SHMT1	-1.11643991765667
NA	NA	hsa04082	Neuroactive ligand signaling	20/1241	199/9376	0.759316323762244	GNAL/HTR1F/GNG12/ADCY5/ADCY6/GABBR1/CHRNA3/GABRE/ADCY9/GABRA3/OGFRL1/ADCY3/PRKACA/ADCY4/SLC6A1/P2RY1/OGFR/GNB4/GNAI3/GNAI1	-1.34034179157912
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1241	19/9376	0.397641969549175	HPSE2	-1.02649287834584
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1241	19/9376	0.397641969549175	BCKDHA	-1.02649287834584
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1241	54/9376	0.55964425343958	HLA-F/HLA-E/HLA-A/HLA-B	-1.26747309467741
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1241	20/9376	0.377759871071716	LSS	-1.08797936226295
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	31/1241	298/9376	0.785943355921021	PRLR/CSF1R/ACKR3/BMP6/IL6ST/NGFR/TGFB2/CCL3/GDF6/IL18/TGFBR2/ACVR2B/CCL4/CCL28/TGFBR1/TNFRSF21/BMPR2/ACVR2A/LIFR/IFNAR1/CCR1/TNFRSF19/IL18R1/BMPR1A/TNFRSF1A/LTBR/TNFSF13B/EPOR/TNFRSF25/CD4/CCL13	-1.46667708099949
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/1241	33/9376	0.457890752814202	BCKDHA/GPT2	-1.21840973767791
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/1241	143/9376	0.686836129221302	C1QA/C2/C1QB/C1QC/ACTN4/C1R/H2AZ2/H2AZ1/RO60/SNRPD3/MACROH2A1/FCGR1A/MACROH2A2	-1.47387619220598
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/1241	46/9376	0.492730266615282	PSMC1/PSMC3/ADRM1	-1.3470068208728
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/1241	116/9376	0.651310122537442	ACSS1/GCK/SDHA/ENO2/GPT2/SHMT1/PFKL/GPI/PFKP/PFKM	-1.47589544189909
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1241	22/9376	0.343418064610651	ALDH3A2	-1.20418811826232
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1241	36/9376	0.419733190079685	UGP2/DCXR	-1.36238010547065
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1241	36/9376	0.419733190079685	GALNT18/GALNT1	-1.36238010547065
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1241	23/9376	0.328486844410188	POMT2	-1.25931891489023
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/1241	23/9376	0.328486844410188	ICMT	-1.25931891489023
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1241	37/9376	0.408389049807261	AOC3/ADH1B	-1.4082495737318
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1241	24/9376	0.314799892559764	HS6ST1	-1.3126941338652
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/1241	168/9376	0.674571198342351	SLC25A6/H2AZ2/STAT3/H2AZ1/MACROH2A1/IFNAR1/STAT6/MACROH2A2/DNM1L/PLA2G4B/SLC25A5/TNFRSF1A/RNF31/PPIA/CHMP3	-1.66234332105033
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/1241	72/9376	0.524666487599606	ADAR/MAVS/ZNFX1/MAP3K7/IRF3	-1.58133026178505
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/1241	94/9376	0.562621084574897	JUN/SRSF1/FOS/MAPK1/FOSB/MAP3K7/TAB2	-1.66453809278973
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/1241	95/9376	0.556698757368845	JUN/TGFB2/CCL3/IL18/FOS/ATP6AP1/TNFSF13B	-1.69611820383877
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/1241	85/9376	0.533308053277717	IMPDH2/NME4/ENPP1/ADSL/ENTPD4/GMPR2	-1.68811212740117
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1241	41/9376	0.368546215679723	GABRE/GABRA3	-1.58259244392984
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	11/1241	138/9376	0.602225881418678	COX4I2/NDUFA4L2/MT-ND1/NDUFS1/ATP5F1B/SDHA/NDUFA10/ATP6AP1/UQCRC1/MT-CO3/ATP5F1A	-1.83856859103736
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/1241	42/9376	0.359771305782587	INMT/ALDH3A2	-1.62412193547152
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1241	28/9376	0.26982847933694	B3GNT2	-1.51125344547315
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1241	99/9376	0.534205878283235	C1QA/C2/C1QB/C1QC/C1R/C3AR1/FCGR1A	-1.81970325859285
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1241	29/9376	0.260524049014977	CALM3	-1.55768516024314
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1241	79/9376	0.478177051989514	HPGDS/CBR1/ADH1B/GSTM3/EPHX1	-1.81910620172992
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/1241	44/9376	0.343418064610651	POLG2/POLG	-1.704985356163
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1241	70/9376	0.431725566939104	HPGDS/CBR1/GSTM3/EPHX1	-1.86388178254572
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1241	31/9376	0.24371604585272	ALDH3A2	-1.64728532908469
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	12/1241	154/9376	0.588716682189688	MOCS1/UGP2/MAT2A/NME4/NAPRT/ADSL/SHMT1/MAT2B/NADK2/PANK3/ALDH3A2/PDXP	-2.00993330270478
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/1241	59/9376	0.384162580750898	NME4/ENPP1/ENTPD4	-1.85330450820764
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/1241	83/9376	0.4551323747852	ECH1/AMACR/DECR2/PEX19/PEX26	-1.94735366297976
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/1241	48/9376	0.314799892559764	BCKDHA/ALDH3A2	-1.85881651624422
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	14/1241	183/9376	0.577993245355632	CSNK2B/RRP7A/XPO1/FBL/SBDS/NOP56/UTP4/RMRP/XRN1/MDN1/HEATR1/CSNK2A2/NAT10/GNL3L	-2.2516924284293
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/1241	38/9376	0.198820984774588	CD4	-1.93280116803051
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/1241	82/9376	0.368546215679723	IMPDH2/NME4/GSTM3/CES2	-2.24305494884086
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/1241	73/9376	0.310487565264424	HPGDS/ADH1B/GSTM3	-2.30985528964916
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1241	68/9376	0.222211688865715	CYP2W1/ADH1B	-2.51408774746785
NA	NA	hsa04382	Cornified envelope formation	14/1241	217/9376	0.48743209170544	TJP1/DST/COL4A5/PLEC/LAMA5/DSP/PPP2CB/PPP2R1A/KDSR/PPL/SPTLC1/FURIN/CLDN12/PPP2R5A	-2.98366458491845
Genetic Information Processing	Translation	hsa03010	Ribosome	13/1241	222/9376	0.442421470624533	RPS4Y1/MRPS18B/RPL4/RPS9/RPS10/RPL35/RPL36A/MRPL38/RPL23A/RPS2/RPL13A/RPL15/MRPS26	-3.28374803239532
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/1241	66/9376	0.11447268820355	HSD17B2	-2.81962815182076
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	24/1241	370/9376	0.490066859768713	AGTR1/EDNRB/PRLR/CYSLTR2/NR3C1/GRID1/HTR1F/PTGER2/GABBR1/CHRNA3/C3AR1/GABRE/ADRB3/PTH1R/VIPR2/GABRA3/OGFRL1/THRA/TBXA2R/P2RY1/OGFR/TMEM97/SPX/EDNRA	-3.90877685848153
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1241	449/9376	0.11778704220499	GNAL/OR51E1/OR51E2/ADCY3/PRKACA/CALM3/PDE2A	-7.48232530331967