category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	120/1353	308/9376	2.69991649149077	ATP5MC3/ATP5F1B/AMBRA1/PPIF/SDHC/ATP5MC1/NDUFV1/UQCRC2/CYC1/POLR2E/VDAC1/NDUFS8/ADRM1/TUBA1C/NDUFB8/SDHD/PSMD2/UQCRFS1/TUBA1B/PSMD13/GPX3/NDUFA10/SLC25A6/COX5A/TGM2/AP2M1/SDHB/TUBB4B/POLR2G/PSMB2/NDUFAB1/NDUFS2/NDUFS7/ATP5F1A/CYCS/PSMD14/NDUFB10/POLR2H/ATP5PB/PSMD11/NDUFA8/TFAM/PSMD4/ATP5F1C/UQCRH/ATP5PO/PSMC3/NDUFB6/PSMA5/PSMB5/ATP5PD/ATP5MC2/PSMD3/ATP5F1D/PSMC5/PSMA1/NDUFS6/PSMB4/DCTN6/COX5B/NDUFA11/VDAC3/NDUFB9/IFT57/NDUFS4/PSMD12/DCTN2/HDAC1/NDUFV2/SLC25A5/POLR2C/SLC25A4/ATG101/PSMC2/PSMC6/POLR2F/RCOR1/NDUFC2/NDUFB5/COX7B/PSMA3/POLR2J/PSMD6/PSMA7/PSMA4/PSMD7/NDUFB2/UQCRC1/NDUFA9/PSMB7/PPARG/PSMB1/PSMD1/NDUFA5/VDAC2/AP2A1/TP53/POLR2D/AP2S1/NDUFB11/COX6A1/NDUFB4/COX7A2L/NDUFB7/UQCR10/TBPL1/COX8A/COX4I1/TUBB6/TRAF2/PSMB6/CLTC/TBP/GPX7/DCTN1/SDHA/UQCRQ/PLCB3/CREB1/ACTR1B	12.4569961458063
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	131/1353	368/9376	2.46685304797712	ATP5MC3/PFN1/ATP5F1B/AMBRA1/SDHC/ATP5MC1/NDUFV1/UQCRC2/CYC1/ALYREF/VCP/SRSF7/HNRNPA1L3/VDAC1/NDUFS8/ADRM1/TUBA1C/NDUFB8/SDHD/PSMD2/UQCRFS1/TUBA1B/PSMD13/GPX3/NDUFA10/TOMM40/COX5A/SDHB/TUBB4B/PSMB2/NDUFAB1/NDUFS2/NDUFS7/ATP5F1A/CYCS/HNRNPA3/PSMD14/NDUFB10/ATP5PB/PSMD11/NDUFA8/PSMD4/ATP5F1C/SRSF3/UQCRH/ATP5PO/PSMC3/HNRNPA2B1/NDUFB6/PSMA5/PSMB5/ATP5PD/ATP5MC2/NXT1/PSMD3/ATP5F1D/PSMC5/ANXA11/PSMA1/MAPK13/NDUFS6/EIF2S1/PSMB4/DCTN6/COX5B/NUP37/NDUFA11/NDUFB9/NUP54/NDUFS4/PSMD12/DCTN2/BAD/NDUFV2/ATG101/CHMP2B/PSMC2/PSMC6/NDUFC2/NDUFB5/COX7B/PSMA3/PSMD6/PSMA7/PSMA4/PSMD7/SEC13/NDUFB2/UQCRC1/ANXA7/NDUFA9/PSMB7/PSMB1/MAP2K3/PSMD1/NDUFA5/RAB8A/MAPK14/TP53/HNRNPA1/RAC1/NUP62/NDUFB11/TPR/SEH1L/COX6A1/NDUFB4/COX7A2L/CCS/NDUFB7/UQCR10/ATXN2L/POM121/VAPB/COX8A/COX4I1/TUBB6/TRAF2/PSMB6/NUP88/TANK/BID/NUP58/GPX7/DCTN1/SDHA/PPP3CB/UQCRQ/SIGMAR1/ACTR1B/POM121C	11.7886064256317
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	104/1353	268/9376	2.68917055520623	ATP5MC3/ATP5F1B/GNAS/PPIF/SDHC/ATP5MC1/NDUFV1/UQCRC2/CYC1/VDAC1/NDUFS8/ADRM1/TUBA1C/NDUFB8/SDHD/PSMD2/UQCRFS1/TUBA1B/PSMD13/NDUFA10/SLC25A6/COX5A/SDHB/TUBB4B/PSMB2/NDUFAB1/CALM3/NDUFS2/NDUFS7/ATP5F1A/TXN2/CYCS/PSMD14/NDUFB10/ATP5PB/PSMD11/NDUFA8/PSMD4/ATP5F1C/UQCRH/ATP5PO/PSMC3/NDUFB6/PSMA5/PSMB5/ATP5PD/ATP5MC2/PSMD3/ATP5F1D/PSMC5/PSMA1/UBE2L3/NDUFS6/EIF2S1/PSMB4/COX5B/UBB/NDUFA11/VDAC3/NDUFB9/NDUFS4/UBE2J1/PSMD12/PARK7/NDUFV2/SLC25A5/SLC25A4/PSMC2/PSMC6/TRAP1/NDUFC2/GNAI3/NDUFB5/COX7B/PSMA3/PSMD6/PSMA7/PSMA4/PSMD7/NDUFB2/UQCRC1/NDUFA9/PSMB7/PSMB1/PSMD1/NDUFA5/VDAC2/TP53/UBE2J2/UBE2G2/NDUFB11/COX6A1/NDUFB4/COX7A2L/NDUFB7/UQCR10/COX8A/COX4I1/TUBB6/TXN/PSMB6/HTRA2/SDHA/UQCRQ	11.5211419851598
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	105/1353	275/9376	2.64591816166096	CAV1/ATP5MC3/ATP5F1B/PPIF/SDHC/ATP5MC1/NDUFV1/UQCRC2/CYC1/VDAC1/NDUFS8/ADRM1/TUBA1C/NDUFB8/SDHD/PSMD2/UQCRFS1/TUBA1B/PSMD13/NDUFA10/SLC25A6/STIP1/COX5A/SDHB/TUBB4B/PSMB2/NDUFAB1/NDUFS2/NDUFS7/ATP5F1A/CYCS/PSMD14/NDUFB10/ATP5PB/PSMD11/NDUFA8/PSMD4/ATP5F1C/UQCRH/ATP5PO/PSMC3/NDUFB6/PSMA5/PSMB5/ATP5PD/ATP5MC2/PSMD3/ATP5F1D/PSMC5/PSMA1/MAPK13/NDUFS6/EIF2S1/PSMB4/COX5B/NDUFA11/VDAC3/NDUFB9/MAPK3/NDUFS4/PSMD12/BAD/NDUFV2/SLC25A5/SLC25A4/PSMC2/PSMC6/NDUFC2/NDUFB5/COX7B/PSMA3/PSMD6/PSMA7/PSMA4/C1QA/PSMD7/NDUFB2/UQCRC1/NDUFA9/PSMB7/PSMB1/PSMD1/NDUFA5/VDAC2/MAPK14/RAC1/NDUFB11/COX6A1/NDUFB4/COX7A2L/NDUFB7/UQCR10/COX8A/ATF2/COX4I1/TUBB6/PSMB6/C1QB/C1QC/CSNK2A2/SDHA/PPP3CB/PIK3R1/UQCRQ/CREB1	11.3761724683484
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	62/1353	138/9376	3.11338196385916	ATP5MC3/ATP5F1B/SDHC/ATP5MC1/NDUFV1/UQCRC2/CYC1/ATP6V1C2/NDUFS8/PPA2/NDUFB8/SDHD/UQCRFS1/NDUFA10/COX5A/SDHB/NDUFAB1/NDUFS2/NDUFS7/ATP5F1A/CYCS/NDUFB10/ATP5PB/NDUFA8/ATP5F1C/UQCRH/ATP5PO/NDUFB6/ATP5PD/ATP5MC2/ATP5F1D/ATP6V1B2/NDUFS6/COX5B/NDUFA11/NDUFB9/ATP6V1D/NDUFS4/ATP6V1F/NDUFV2/NDUFC2/NDUFB5/COX7B/ATP6V0D1/PPA1/NDUFB2/UQCRC1/NDUFA9/COX11/NDUFA5/LHPP/NDUFB11/COX6A1/NDUFB4/COX7A2L/NDUFB7/UQCR10/COX8A/COX4I1/ATP6V1B1/SDHA/UQCRQ	10.2705736527947
Genetic Information Processing	Translation	hsa03010	Ribosome	83/1353	222/9376	2.59086581037801	RPS10/RPL18A/MRPL4/RPLP0/MRPS25/RACK1/RPS4Y1/RPL10/MRPL34/MRPL16/MRPS2/MRPS26/RPS5/MRPL12/RPS26/MRPL21/MRPL15/MRPS35/MRPL17/MRPS34/MRPL48/RPL4/MRPS16/MRPL27/MRPS22/RPS2/MRPL9/MRPL44/MRPS15/MRPL24/MRPS7/RPS6/MRPL11/MRPL47/MRPL2/MRPL41/MRPL13/RPL8/MRPL35/MRPS28/MRPL40/MRPS14/RPS3/MRPL3/MRPS18C/MRPL19/MRPL37/RPL13/RPL19/MRPL10/RPL26L1/MRPL36/RPS8/MRPS6/MRPL54/DAP3/MRPL22/MRPL42/MRPL39/MRPS10/MRPS18A/RPS24/RPS7/MRPL50/MRPL49/RPSA/MRPL43/RPL29/MRPL18/MRPS31/MRPS11/MRPL32/RPS14/RPL10A/MRPS27/RPL13A/RPLP1/MRPS30/MRPS9/RPL23A/RPS13/RPS16/RPL15	9.85078231441084
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	140/1353	480/9376	2.02118748460212	ATP5MC3/ATP5F1B/AMBRA1/PPIF/SDHC/ATP5MC1/NDUFV1/UQCRC2/CYC1/VCP/VDAC1/NDUFS8/ADRM1/TUBA1C/NDUFB8/SDHD/PSMD2/UQCRFS1/TUBA1B/PSMD13/GPX3/NDUFA10/SLC25A6/HSD17B10/TOMM40/COX5A/SDHB/TUBB4B/PPID/CTNNB1/PSMB2/NDUFAB1/CALM3/NDUFS2/NDUFS7/ATP5F1A/CYCS/FADD/PSMD14/NDUFB10/ATP5PB/PSMD11/NDUFA8/MAP2K2/PSMD4/ATP5F1C/UQCRH/ATP5PO/PSMC3/NDUFB6/PSMA5/PSMB5/CAPN1/ATP5PD/ATP5MC2/PSMD3/ATP5F1D/PSMC5/PSMA1/MAPK13/UBE2L3/NDUFS6/EIF2S1/PSMB4/DCTN6/COX5B/UBB/NDUFA11/VDAC3/NDUFB9/IFT57/MAPK3/NDUFS4/UBE2J1/PSMD12/DCTN2/PARK7/BAD/NDUFV2/SLC25A5/SLC25A4/ATG101/CHMP2B/PSMC2/PSMC6/TRAP1/NDUFC2/NDUFB5/COX7B/PSMA3/PSMD6/PSMA7/PSMA4/PSMD7/NDUFB2/UQCRC1/NDUFA9/PSMB7/PSMB1/MAP2K3/PSMD1/NDUFA5/RAB8A/VDAC2/MAPK14/UBE2J2/UBE2G2/RAC1/NDUFB11/COX6A1/NDUFB4/COX7A2L/CCS/NDUFB7/UQCR10/ATXN2L/VAPB/COX8A/COX4I1/TUBB6/FRAT2/TRAF2/BAK1/PSMB6/TANK/HTRA2/RAF1/BID/CSNK2A2/GPX7/DCTN1/SDHA/PPP3CB/NFKB1/UQCRQ/CASP7/SIGMAR1/PLCB3/ACTR1B/TPTEP2-CSNK1E	9.43180591812077
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	78/1353	205/9376	2.63669893461684	GAPDH/ATP5MC3/ATP5F1B/PPIF/PARP1/SDHC/ATP5MC1/NDUFV1/UQCRC2/CYC1/VDAC1/NDUFS8/NDUFB8/SDHD/UQCRFS1/PRKCZ/NDUFA10/SLC25A6/CPT2/COX5A/SDHB/NDUFAB1/NDUFS2/NDUFS7/ATP5F1A/PDHA1/PPP1CC/PPP1CA/NDUFB10/ATP5PB/NDUFA8/AKT1/ATP5F1C/UQCRH/ATP5PO/NDUFB6/ATP5PD/ATP5MC2/ATP5F1D/MAPK13/NDUFS6/COX5B/MPC2/NDUFA11/VDAC3/NDUFB9/NDUFS4/PDHB/NDUFV2/SLC25A5/SLC25A4/NDUFC2/NDUFB5/COX7B/NDUFB2/UQCRC1/NDUFA9/NDUFA5/VDAC2/CTSD/MAPK14/RAC1/NDUFB11/COX6A1/NDUFB4/COX7A2L/NDUFB7/UQCR10/GFPT1/COX8A/COX4I1/SDHA/PIK3R1/NFKB1/UQCRQ/PDK3/PLCB3/PTPA	9.72979127734851
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	84/1353	235/9376	2.47702976836345	ATP5MC3/ATP5F1B/GNAS/SDHC/ATP5MC1/NDUFV1/UQCRC2/CYC1/NDUFS8/NDUFB8/SDHD/UQCRFS1/NDUFA10/CPT2/COX5A/SDHB/NDUFAB1/NDUFS2/NDUFS7/ATP5F1A/COA4/NDUFAF3/NDUFB10/ATP5PB/NDUFA8/NDUFAF4/ATP5F1C/UQCRH/ATP5PO/NDUFB6/ATP5PD/ATP5MC2/GRB2/RPS6/ATP5F1D/MAPK13/COA6/NDUFS6/COA3/COX20/COX5B/NDUFA11/NDUFB9/SLC25A29/NDUFS4/NDUFV2/ACTL6A/NDUFC2/NDUFB5/RHEB/COX7B/NDUFAF2/SMARCC1/AKT1S1/NDUFB2/UQCRC1/KDM1A/NDUFA9/COX11/PPARG/SMARCA4/MAP2K3/NDUFA5/MAPK14/NDUFB11/COX6A1/NDUFB4/RPS6KB1/COX7A2L/COA7/NDUFB7/UQCR10/NDUFAF1/COX8A/ATF2/COX4I1/COA5/MLST8/SDHA/RPS6KB2/UQCRQ/CREB1/NDUFAF5/NDUFAF6	9.41656406235814
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	118/1353	388/9376	2.10751213416539	GAPDH/ATP5MC3/ATP5F1B/AMBRA1/PPIF/SDHC/ATP5MC1/NDUFV1/UQCRC2/CYC1/VDAC1/NDUFS8/ADRM1/TUBA1C/NDUFB8/SDHD/PSMD2/UQCRFS1/TUBA1B/PSMD13/NDUFA10/SLC25A6/HSD17B10/COX5A/SDHB/TUBB4B/PPID/CTNNB1/PSMB2/NDUFAB1/CALM3/NDUFS2/NDUFS7/ATP5F1A/CYCS/FADD/PSMD14/NDUFB10/ATP5PB/PSMD11/NDUFA8/MAP2K2/PSMD4/AKT1/ATP5F1C/UQCRH/ATP5PO/PSMC3/NDUFB6/PSMA5/PSMB5/CAPN1/ATP5PD/ATP5MC2/PSMD3/ATP5F1D/PSMC5/PSMA1/NDUFS6/EIF2S1/PSMB4/COX5B/NDUFA11/VDAC3/NDUFB9/MAPK3/NDUFS4/PSMD12/BAD/NDUFV2/NAE1/SLC25A5/SLC25A4/ATG101/PSMC2/PSMC6/NDUFC2/NDUFB5/COX7B/PSMA3/PSMD6/PSMA7/PSMA4/PSMD7/NDUFB2/UQCRC1/NDUFA9/PSMB7/PSMB1/PSMD1/NDUFA5/VDAC2/BACE2/NDUFB11/PSENEN/COX6A1/NDUFB4/COX7A2L/NDUFB7/UQCR10/COX8A/COX4I1/TUBB6/FRAT2/TRAF2/PSMB6/RAF1/BID/CSNK2A2/SDHA/PPP3CB/PIK3R1/NFKB1/UQCRQ/CASP7/IDE/PLCB3/TPTEP2-CSNK1E	9.14953377119107
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	81/1353	227/9376	2.47274290123758	ATP5MC3/ATP5F1B/PPIF/SDHC/ATP5MC1/GSTT1/NDUFV1/UQCRC2/CYC1/GSTA4/VDAC1/NDUFS8/NDUFB8/SDHD/UQCRFS1/NDUFA10/SLC25A6/GSTA3/COX5A/SDHB/NDUFAB1/NDUFS2/NDUFS7/ATP5F1A/NDUFB10/ATP5PB/NDUFA8/MAP2K2/AKT1/ATP5F1C/UQCRH/ATP5PO/AKR1A1/NDUFB6/ATP5PD/ATP5MC2/GRB2/ATP5F1D/MAPK13/NDUFS6/COX5B/NDUFA11/VDAC3/NDUFB9/MAPK3/NDUFS4/BAD/NDUFV2/SLC25A5/PTPN1/SLC25A4/NDUFC2/NDUFB5/COX7B/NDUFB2/UQCRC1/NDUFA9/NDUFA5/VDAC2/MAPK14/GSTO1/RAC1/NDUFB11/PDPK1/COX6A1/NDUFB4/COX7A2L/ACP1/NDUFB7/UQCR10/EPHX2/COX8A/COX4I1/PTPN11/RAF1/SDHA/PIK3R1/NFKB1/UQCRQ/EPHX1/PLD2	9.2239978544716
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	52/1353	116/9376	3.10645564135892	GAPDH/MDH2/ENO1/ECHS1/PGAM1/PKM/SDHC/TPI1/ACSS1/SDHD/RPIA/MDH1/IDH3A/FH/SDHB/PHGDH/SHMT2/PDHA1/PGK1/ADH5/ACADS/IDH1/PGP/IDH2/ACO2/PGLS/IDH3B/IDH3G/PFKL/RPE/SUCLG1/GPI/PDHB/HIBCH/GOT1/DLD/ESD/GLUD1/ACAT1/GOT2/SUCLG2/PSAT1/PCCB/DLST/ALDOA/ACAT2/ACOX1/GLYCTK/ME2/SDHA/ACOX3/OGDH	9.3743671688915
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	29/1353	46/9376	4.36877791702818	ADRM1/PSMD2/PSMD13/PSMB2/PSMF1/PSMD14/PSMD11/PSMD4/PSMC3/PSMA5/PSMB5/PSMD3/PSMC5/PSMA1/PSMB4/PSMD12/PSMC2/PSMC6/PSME3/PSMA3/PSMD6/PSMA7/PSMA4/PSMD7/PSMB7/PSMB1/PSMD1/POMP/PSMB6	9.40538582826974
Genetic Information Processing	Transcription	hsa03040	Spliceosome	79/1353	243/9376	2.25289328089689	U2AF1/SNRPD3/THOC3/HNRNPM/ALYREF/SRSF7/HNRNPA1L3/SRSF9/CTNNBL1/PRPF19/SF3B2/SNRNP40/SRSF2/SNRPA1/U2AF2/SF3A3/SNRPD1/HNRNPA3/SNRNP70/SRSF6/LSM4/SNRPE/SNRPA/SRSF4/SRSF3/HNRNPC/MAGOH/THOC6/RBM17/LSM6/PPIL1/DDX46/SNRPB/SNRPC/RBM25/HNRNPU/EIF4A3/TXNL4A/PPIH/SNRPB2/NCBP2/RBMX/SF3B5/SMNDC1/USP39/SRSF10/SF3B4/PHF5A/CCDC12/LSM3/RBM22/RBM8A/DDX42/HNRNPK/SNU13/THOC1/LSM5/PPIE/CDC5L/ACIN1/PRPF40A/BCAS2/PRPF4/HNRNPA1/TCERG1/MAGOHB/PRPF6/PLRG1/SF3A2/EFTUD2/SART1/YJU2/SNRPF/PRPF18/SNRPG/SF3A1/CDC40/XAB2/ISY1	8.12599645544825
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	26/1353	44/9376	4.09487334542767	PARP1/APEX1/ADPRS/POLD2/POLE4/HMGB1/UNG/SMUG1/RFC2/POLD3/PCNA/MPG/TDG/RFC1/APTX/RFC4/RFC3/RFC5/MUTYH/FEN1/LIG3/POLE2/TDP1/NEIL2/NTHL1/PARG	8.44983044086699
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	23/1353	36/9376	4.4273630615094	SSBP1/RNASEH2C/POLD2/MCM7/POLE4/MCM5/MCM3/RFC2/RPA3/RPA2/POLD3/PCNA/RFC1/MCM4/MCM2/RFC4/RFC3/RFC5/FEN1/RNASEH1/POLE2/RNASEH2A/POLA2	8.46065652489233
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	55/1353	157/9376	2.4276319196313	SDHC/NDUFV1/UQCRC2/CYC1/NDUFS8/NDUFB8/SDHD/UQCRFS1/NDUFA10/COX5A/SDHB/NDUFAB1/NDUFS2/NDUFS7/CYCS/NDUFB10/NDUFA8/AKT1/UQCRH/NDUFB6/MAPK13/NDUFS6/EIF2S1/COX5B/NDUFA11/NDUFB9/NDUFS4/NDUFV2/NDUFC2/NDUFB5/COX7B/NDUFB2/UQCRC1/NDUFA9/PPARG/GSK3A/NDUFA5/MAPK14/RAC1/NDUFB11/COX6A1/NDUFB4/COX7A2L/NDUFB7/UQCR10/COX8A/COX4I1/TRAF2/MLX/BID/SDHA/PIK3R1/NFKB1/UQCRQ/CASP7	7.40781808315357
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	20/1353	30/9376	4.61985710766199	MDH2/SDHC/SDHD/MDH1/IDH3A/FH/SDHB/PDHA1/IDH1/IDH2/ACO2/IDH3B/IDH3G/SUCLG1/PDHB/DLD/SUCLG2/DLST/SDHA/OGDH	8.15464964257187
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	48/1353	144/9376	2.30992855383099	AMBRA1/PPIF/VDAC1/ADRM1/PSMD2/PSMD13/SLC25A6/PSMB2/CYCS/PSMD14/PSMD11/PSMD4/AKT1/PSMC3/PSMA5/PSMB5/NOP56/ATXN10/PSMD3/PSMC5/PSMA1/PSMB4/VDAC3/PSMD12/SLC25A5/SLC25A4/ATG101/PSMC2/PSMC6/PSMA3/PSMD6/PSMA7/PSMA4/PSMD7/PSMB7/PSMB1/PSMD1/VDAC2/ATXN2L/TBPL1/AFG3L2/TRAF2/RBPJ/PSMB6/TBP/PIK3R1/PLCB3/OPA1	6.5049969539883
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	50/1353	154/9376	2.24993040957564	NME1/AK3/AK2/QPRT/SHMT2/AKR1A1/MOCS2/GSS/NME4/CMPK1/MMAB/ADSS2/COQ4/UROS/HMBS/PDXK/MTHFD1/DLD/BCAT2/DHFR/FECH/NME6/PMM2/COQ5/ALAS1/EPRS1/PANK2/MPI/PSAT1/GGH/UMPS/MTHFD2L/MAT2A/FLAD1/NADK/COASY/COQ3/VKORC1L1/MTHFD1L/GCLM/COQ6/EARS2/NFS1/COQ2/ALDH3A2/GMPPA/OXSM/SPR/AFMID/NADK2	6.4224358644287
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	27/1353	63/9376	2.96990814063985	POLR2E/POLR2G/RAD23A/POLD2/DDB1/POLR2H/POLE4/RAD23B/GTF2H5/POLR2C/POLR2F/RFC2/RPA3/POLR2J/RPA2/POLD3/PCNA/POLR2D/RFC1/RFC4/MNAT1/RFC3/RFC5/POLE2/GTF2H3/ERCC1/ERCC8	6.4422502134256
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	49/1353	158/9376	2.14911074312124	CCNE1/CCND3/E2F4/ANAPC11/CDK4/MCM7/MCM5/MCM3/ANAPC13/YWHAB/SKP2/TFDP1/CCND1/YWHAH/HDAC1/PPP2R1A/ANAPC4/MAD2L2/CDC6/E2F5/CUL1/MYC/BUB3/ANAPC15/ORC6/PCNA/CDC26/TP53/CCNB2/MCM4/MCM2/CDC23/PPP2R5E/ORC3/CDT1/CDC16/PDS5A/MAD2L1/CCNA2/WAPL/ORC5/CDC20/ANAPC7/FBXO5/MAD2L1BP/TRIP13/DBF4/ANAPC1/RB1	5.98188716674016
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	21/1353	43/9376	3.38431392770587	ECHS1/ALDH7A1/HADHB/ECI1/CPT2/ADH5/ACADS/HADH/ACAA1/ACADVL/ECI2/ACAT1/ALDH9A1/ACADM/HADHA/ACAT2/ACOX1/ALDH3A2/GCDH/ACOX3/ACADSB	6.43506845114683
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	37/1353	108/9376	2.37409323588185	THOC3/ALYREF/RAN/UBE2I/RNPS1/MAGOH/SUMO3/THOC6/KPNB1/NXT1/SUMO1/EIF4A3/NUP37/NCBP2/NUP54/IPO5/CSE1L/RBM8A/SEC13/THOC1/ACIN1/AAAS/MAGOHB/NUP62/TNPO1/TPR/SEH1L/NUP42/UPF1/POM121/NUP88/TNPO3/SNUPN/KPNA6/NUP58/DDX19A/POM121C	5.89795164121954
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	22/1353	48/9376	3.17615176151762	ECHS1/ALDH7A1/HADHB/HSD17B10/ACADS/HIBADH/HADH/HIBCH/ACAA1/IVD/DLD/BCAT2/ACAT1/ALDH9A1/ACADM/ACAD8/PCCB/HADHA/ACAT2/MCCC2/ALDH3A2/ACADSB	6.2069989153976
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	23/1353	57/9376	2.79622930200594	HSD17B4/ECHS1/HADHB/CPT2/ACADS/SCP2/HADH/ACAA1/ACADVL/MECR/ACAT1/TECR/ACADM/HADHA/ACAT2/ACOX1/HSD17B12/CBR4/OXSM/ACOX3/ELOVL1/ACADSB/ELOVL5	5.58573964586097
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	22/1353	54/9376	2.82324601023788	MDH2/SRM/DNMT1/AHCY/MDH1/PHGDH/SMS/ENOPH1/GSS/MTAP/CISD1/TST/AHCYL1/AMD1/MPST/GOT1/BCAT2/GOT2/PSAT1/MAT2A/GCLM/DNMT3A	5.51764484678905
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	42/1353	142/9376	2.04965491396271	UBE2N/UBE2I/ANAPC11/PRPF19/UBE2E1/DDB1/SIAH1/CDC34/UBE2M/UBE2D2/ANAPC13/UBE2L3/SKP2/UBB/UBE2E3/UBE2R2/UBE2J1/ANAPC4/SAE1/UBE2H/CUL1/ANAPC15/UBE2F/CDC26/STUB1/UBE2J2/UBE2G2/UBA2/VHL/CDC23/UBA3/CDC16/UBE2D4/WWP1/FBXO4/CDC20/PIAS4/KLHL9/ANAPC7/ERCC8/WWP2/ANAPC1	5.17561449800215
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	16/1353	34/9376	3.26107560540846	POLR2E/POLR2G/POLR2H/POLR1F/POLR2C/POLR2F/POLR2J/POLR1D/POLR3H/POLR1G/POLR2D/POLR3K/POLR1C/POLR1E/POLR3B/CRCP	5.42376359701031
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	19/1353	47/9376	2.80140271422057	MDH2/PKM/ALDH7A1/ACSS1/MDH1/FH/PDHA1/ADH5/AKR1A1/PDHB/DLD/ACAT1/GRHPR/ALDH9A1/ACAT2/ALDH3A2/ME2/ACYP1/ACYP2	5.08403270430786
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	12/1353	23/9376	3.61554034512677	SSBP1/POLD2/RFC2/RPA3/RPA2/POLD3/PCNA/RFC1/RFC4/MSH6/RFC3/RFC5	5.15722423336602
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	60/1353	248/9376	1.6765610471354	GAPDH/PFN1/HSP90AB1/TUBA1C/TUBA1B/TUBB4B/DYNLL1/CTNNB1/RAB7A/TXN2/CYCS/FADD/MAP2K2/AKT1/BRK1/ARPC5/ARPC2/CASP4/MAPK13/RAB5C/DCTN6/RPS3/MAPK3/DCTN2/RALA/RHOG/MYL12A/CSE1L/MYC/MAP2K3/MAPK14/ARPC4/ROCK2/RAC1/ARPC5L/M6PR/RHOA/ARPC3/DNM2/FBXO22/MAP3K7/TUBB6/TXN/TRAF2/BAK1/EXOC7/PYCARD/SNX18/RAF1/TRADD/IRAK1/ARL8A/DYNC2LI1/DCTN1/NFKB1/CASP7/TCF7L2/DYNC1LI1/ACTR1B/EXOC4	4.43415790628945
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	25/1353	75/9376	2.30992855383099	GAPDH/ENO1/PGAM1/PKM/TPI1/RPIA/IDH3A/ASS1/PHGDH/SHMT2/PGK1/PYCR2/IDH1/IDH2/ACO2/IDH3B/IDH3G/PFKL/RPE/GOT1/BCAT2/GOT2/PSAT1/MAT2A/ALDOA	4.67713126744304
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	30/1353	103/9376	2.01838417325038	ALYREF/DAZAP1/SSU72/GSPT1/PPP1CC/PPP1CA/RNPS1/MAGOH/NXT1/ETF1/PABPC4/EIF4A3/PAPOLA/CPSF6/NCBP2/PPP2R1A/RBM8A/HBS1L/ACIN1/FIP1L1/PELO/MAGOHB/CSTF3/CPSF4/PPP2R5E/UPF1/CSTF2/DDX19A/CPSF3/PPP2R3C	4.26762513345891
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	14/1353	33/9376	2.93990906851217	IDH3A/PDHA1/IDH1/IDH2/ACO2/IDH3B/IDH3G/PDHB/GOT1/DLD/BCAT2/GOT2/DLST/OGDH	4.58417627481979
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/1353	85/9376	2.1196991435155	PNP/NME1/AK3/AK2/APRT/DCTPP1/DUT/NME4/CMPK1/ADSS2/GMPS/ITPA/HDDC2/DGUOK/NT5C3B/NTPCR/NME6/ADK/DTYMK/GMPR/NT5C/TK1/NT5C2/NT5C3A/HPRT1/NUDT16	4.25839280346547
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	24/1353	78/9376	2.13224174199784	ENO1/HSPD1/HSPA9/LSM4/LSM6/EXOSC3/EXOSC8/PABPC4/PFKL/EXOSC5/MPHOSPH6/LSM3/DHX36/EXOSC6/DCPS/LSM5/XRN2/EXOSC7/PNPT1/EXOSC4/EXOSC2/CNOT9/NUDT16/CNOT8	4.1234224646598
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	13/1353	31/9376	2.90603914836802	MDH2/ACSS1/MDH1/SHMT2/PGP/ACO2/DLD/ACAT1/GRHPR/PCCB/ACAT2/GLYCTK/AFMID	4.36504927762583
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	32/1353	117/9376	1.89532599288697	H2AZ1/H2AZ2/MACROH2A1/H2AJ/MBD3/BCL7B/MORF4L2/RUVBL2/H2AX/RUVBL1/CDK2AP1/BRD7/MBD2/YY1/CDK2AP2/HDAC1/ACTL6A/UCHL5/DMAP1/SMARCC1/SMARCA4/BAZ1B/MEAF6/BCL7C/CHRAC1/VPS72/MCRS1/MTA2/ING3/PBRM1/PHF10/MRGBP	4.0018261908231
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	21/1353	67/9376	2.17202237151272	GAPDH/ENO1/PGAM1/PKM/PGM1/TPI1/ALDH7A1/ACSS1/PDHA1/PGK1/ADH5/AKR1A1/PFKL/GPI/PDHB/DLD/ALDH9A1/ALDOA/ALDH3A2/G6PC3/GALM	3.95355630429114
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	17/1353	50/9376	2.35612712490761	SRM/ALDH7A1/OAT/CKMT1B/CNDP2/SMS/PYCR2/LAP3/AMD1/GOT1/ALDH9A1/CKMT1A/GOT2/ALDH3A2/ALDH4A1/L3HYPDH/GAMT	3.94824268763301
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/1353	37/9376	2.43478955674078	CTNNB1/TFG/MAP2K2/CCND1/MAPK3/TPM3/CCDC6/MYC/PPARG/TP53/TPR/BAK1/TCF7L2	3.59091414471835
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	37/1353	157/9376	1.63313420047924	CCNE1/CCND3/VDAC1/E2F4/SLC25A6/PPID/CALM3/CDK4/PPP1CC/PPP1CA/MAP2K2/AKT1/CAPN1/MAPK13/CCND1/VDAC3/MAPK3/SLC25A5/SLC25A4/RHEB/E2F5/MYC/MAP2K3/VDAC2/MAPK14/TP53/CCNB2/RAD1/MRE11/HUS1/NBN/RAF1/CCNA2/PPP3CB/PIK3R1/NFKB1/RB1	3.28526065779221
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	45/1353	205/9376	1.52117246227895	CCNE1/CCND3/ADRM1/PSMD2/PSMD13/CDK4/CYCS/FADD/PSMD14/PSMD11/PSMD4/AKT1/PSMC3/PSMD3/PSMC5/MAPK13/SKP2/CCND1/PSMD12/HDAC1/PSMC2/PSMC6/PSMD6/MYC/PSMD7/MAP2K3/PSMD1/USP7/MAPK14/TP53/RAC1/MAP3K7/TRAF2/BAK1/RBPJ/BID/CCNA2/TRADD/IRAK1/PIK3R1/NFKB1/SAP30L/RELB/RB1/PLCG2	3.0982480468609
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	23/1353	87/9376	1.83201230131424	CTNNB1/CYCS/MAP2K2/AKT1/GRB2/CCND1/MAPK3/RALA/BAD/MYC/TP53/RAC1/RPS6KB1/APPL1/RHOA/BAK1/MSH6/RAF1/RAC3/RPS6KB2/PIK3R1/TCF7L2/RALB	3.20162920313475
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	13/1353	39/9376	2.30992855383099	ALDH7A1/AHCY/ATIC/SHMT2/AHCYL1/MTHFD1/DLD/DHFR/GART/MTHFD2L/MAT2A/MTHFD1L/ST20-MTHFS	3.36621905074721
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	48/1353	224/9376	1.48495407031992	CCNE1/CCND3/RANBP1/NFYB/RAN/VDAC1/MSX2/SLC25A6/ANAPC11/CDK4/MAP2K2/AKT1/FDPS/TLN1/ANAPC13/CCND1/VDAC3/MAPK3/SLC25A5/SLC25A4/ANAPC4/MYC/BUB3/ANAPC15/VDAC2/CDC26/TP53/CCNB2/CDC23/CDC16/TBPL1/ATF2/MAD2L1/CCNA2/TBP/RANBP3/CDC20/PPP3CB/PIK3R1/NFKB1/ANAPC7/KAT2A/CREB1/TCF3/RELB/ANAPC1/VAC14/RB1	3.01670437162037
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	10/1353	27/9376	2.56658728203444	HSD17B4/SCP2/ACAA1/TECR/ACOT4/ACOX1/HSD17B12/ACOX3/ELOVL1/ELOVL5	3.34749578691756
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	6/1353	12/9376	3.46489283074649	COQ4/COQ5/COQ3/VKORC1L1/COQ6/COQ2	3.50852117977395
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/1353	32/9376	2.38211382113821	ECHS1/ACSS1/ACADS/SUCLG1/HIBCH/DLD/SUCLG2/PCCB/HADHA/ACOX1/ACOX3	3.21601839832184
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	13/1353	41/9376	2.1972491121807	SSBP1/POLD2/BABAM1/RPA3/RPA2/POLD3/MRE11/NBN/BRCC3/BABAM2/RAD51/TOPBP1/UIMC1	3.15489878824682
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	10/1353	28/9376	2.47492345053321	ECHS1/HADHB/HADH/MECR/TECR/ACOT4/HADHA/HSD17B12/ELOVL1/ELOVL5	3.20963232276716
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	52/1353	253/9376	1.42430377232267	H3-3A/U2AF1/PFN1/H3-3B/VDAC1/UBE2N/FOXO4/RRAGA/PPID/CYCS/AKT1/UBE2D2/CAPN1/TLN1/ARPC5/ARPC2/CASP4/MAPK13/HCLS1/UBB/MAPK3/MYL12A/SEPTIN9/CBX3/CUL1/AKT1S1/GSK3A/MAPK14/SHARPIN/ARPC4/TP53/ATG5/ROCK2/RAC1/ARPC5L/ACTN1/RPS6KB1/RHOA/ARPC3/MAP3K7/TRAF2/DOCK1/PYCARD/TRADD/UBE2D4/GLMN/RPS6KB2/PIK3R1/NFKB1/PLCB3/BCL10/PLCG2	2.80953506315031
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	20/1353	78/9376	1.77686811833153	CAV1/CTNNB1/CTNNA1/ARPC5/ARPC2/HCLS1/RHOG/MAD2L2/SEPTIN9/ARPC4/RAC1/ARPC5L/RHOA/ARPC3/DNM2/DOCK1/ARHGAP10/CLTC/PIK3R1/ELMO3	2.82921511580549
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	31/1353	137/9376	1.56805368982688	PARP1/TUBA1C/TUBA1B/CYCS/FADD/MAP2K2/AKT1/CAPN1/CTSC/DFFA/EIF2S1/LMNA/MAPK3/BAD/CTSD/TP53/PDPK1/LMNB2/AIFM1/TRAF2/BAK1/HTRA2/RAF1/BID/TRADD/LMNB1/PIK3R1/NFKB1/CASP7/CASP2/CASP6	2.75044728438959
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	16/1353	59/9376	1.87926390820149	SRM/GSTT1/GSTA4/GPX3/GSTA3/SMS/IDH1/IDH2/GSS/LAP3/GSTP1/GSTK1/GSTO1/GCLM/PRDX6/GPX7	2.78210390089635
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	50/1353	250/9376	1.3859571322986	ATP6V1C2/TFEB/RRAGA/AP2M1/RAB7A/AP1S3/LAMTOR2/LAMTOR1/CTSC/FUCA1/KXD1/ATP6V1B2/AP1S1/ATP6V1D/DTNBP1/ATP6V1F/ATP6V0D1/AKT1S1/BLOC1S4/SNAPIN/CTSD/VPS29/SLC29A1/VPS26A/AP2A1/LAMTOR5/LGMN/AP1B1/LAMP1/HEXA/AP2S1/VAMP7/M6PR/AP3M1/MLST8/ATP6V1B1/AP5S1/LAPTM4B/GLA/NAGA/CLTC/ARL8A/AP5M1/BORCS6/BLOC1S5/AP3B1/ROGDI/AGA/AP1M1/HYAL2	2.54000740888376
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/1353	31/9376	2.23541472951386	ECHS1/ALDH7A1/CNDP2/ACADS/HIBCH/ALDH9A1/HADHA/ACOX1/ALDH3A2/ACOX3	2.82924208416708
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	28/1353	125/9376	1.55227198817443	PRKCZ/MAP2K2/AKT1/DEGS1/MAPK13/MAPK3/PPP2R1A/GNAI3/GNA12/S1PR2/CTSD/MAPK14/TP53/ROCK2/RAC1/PDPK1/PPP2R5E/RHOA/TRAF2/RAF1/BID/TRADD/RAC3/PIK3R1/NFKB1/PLCB3/PPP2R3C/PLD2	2.55258270483885
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	42/1353	205/9376	1.41976096479368	CCNE1/PKM/H4C3/CCND3/RANBP1/CDK4/DDB1/GRB2/YWHAB/SKP2/HDAC3/CCND1/YWHAH/VDAC3/SND1/MAPK3/HDAC1/BAD/HNRNPK/ATP6V0D1/USP7/TP53/RAC1/ACTN1/RHOA/TBPL1/ATF2/TRAF2/BAK1/RBPJ/CCNA2/TRADD/TBP/CDC20/PIK3R1/NFKB1/GTF2H3/KAT2A/CREB1/REL/VAC14/RB1	2.49538048045293
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	19/1353	77/9376	1.70994711127749	CDK4/AKT1/CCND1/MAPK3/RALA/BAD/TP53/RAC1/RPS6KB1/RAD51/BAK1/RAF1/RAC3/RPS6KB2/PIK3R1/NFKB1/RALB/RB1/PLD2	2.5687354279679
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	38/1353	183/9376	1.43897188599308	NHP2/RAN/NOB1/GNL3/GAR1/IMP4/EMG1/EIF6/RPP30/NOP56/NXT1/UTP6/NOP10/NOP58/REXO2/IMP3/WDR43/DKC1/SNU13/XRN2/GNL2/RPP25L/UTP18/RRP7A/RIOK1/GTPBP4/POP4/LSG1/RBM28/RPP40/BMS1/POP5/TBL3/CSNK2A2/TCOF1/NAT10/MPHOSPH10/RCL1	2.46263338018891
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	8/1353	23/9376	2.41036023008451	FDPS/FNTA/ACAT1/PMVK/ICMT/PDSS1/ACAT2/GGPS1	2.78089533962627
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	11/1353	37/9376	2.06020654801143	ASS1/NIT2/ADSS2/GOT1/GLUD1/RIMKLB/GOT2/GLS/GFPT1/ALDH4A1/PPAT	2.65342793421591
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	12/1353	42/9376	1.97993876042657	ECHS1/ALDH7A1/HADH/DLD/ACAT1/ALDH9A1/HADHA/DLST/ACAT2/ALDH3A2/AFMID/GCDH	2.61370051466187
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	24/1353	105/9376	1.58395100834125	AMBRA1/VCP/TFEB/TOMM40/RAB7A/SIAH1/MTX2/FKBP8/RAB5C/EIF2S1/CCZ1/UBB/MTX1/MARCHF5/TOMM70/TP53/SAMM50/PHB2/FIS1/PGAM5/TRAF2/RHOT1/CSNK2A2/OPA1	2.47100663809637
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	28/1353	128/9376	1.51589061345159	PNP/NME1/PGM1/AK3/AK2/APRT/PAICS/ATIC/NME4/ADSS2/NUDT5/GMPS/ITPA/HDDC2/DGUOK/NTPCR/NME6/ADK/GART/GMPR/NT5C/NUDT2/NT5C2/HDDC3/PDE6D/PPAT/HPRT1/NUDT16	2.41326403544634
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/1353	33/9376	2.09993504893727	SEC22B/STX18/STX6/VAMP7/USE1/GOSR2/BET1/BNIP1/YKT6/GOSR1	2.59924356096144
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	33/1353	158/9376	1.44736029638777	ATP6V1C2/RRAGA/EIF4B/MAP2K2/AKT1/EIF4E/LAMTOR2/LAMTOR1/GRB2/RPS6/ATP6V1B2/SKP2/ATP6V1D/MAPK3/ATP6V1F/RHEB/AKT1S1/SEC13/CAB39L/PRR5/LAMTOR5/SEH1L/PDPK1/RPS6KB1/RHOA/STRADB/MLST8/ATP6V1B1/RAF1/TBC1D7/RPS6KB2/PIK3R1/WDR59	2.32880845635672
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/1353	59/9376	1.76180991393889	NME1/DCTPP1/DUT/NME4/CMPK1/HDDC2/NT5C3B/NME6/DTYMK/NT5C/TK1/UMPS/NUDT2/NT5C2/NT5C3A	2.41046438224237
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/1353	59/9376	1.76180991393889	CTNNB1/MAP2K2/AKT1/CTNNA1/GRB2/CCND1/MAPK3/BAD/MYC/TP53/PDPK1/BAK1/RAF1/PIK3R1/TCF7L2	2.41046438224237
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	48/1353	250/9376	1.33051884700665	CAV1/PRKCZ/AP2M1/RAB7A/CAPZB/SNX4/SPG21/SH3GLB2/ARPC5/ARPC2/CAPZA1/RAB5C/RAB11B/CHMP1A/RAB10/ARF4/SNX1/CHMP2B/SNX5/SNF8/SNX3/ARRB1/RAB8A/VPS29/ARPC4/VPS26A/AP2A1/LDLRAP1/EPN1/ARFGAP2/MVB12A/AP2S1/CHMP4B/ARPC5L/RHOA/SH3GLB1/EHD4/ARPC3/DNM2/GRK6/CLTC/WWP1/FOLR2/CHMP6/MVB12B/AGAP3/EPS15L1/PLD2	2.17516467482487
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	26/1353	122/9376	1.47683956720342	AKT1/RAB11B/PFKL/RAB10/CCND1/ELAVL1/PPP2R1A/RHEB/AKT1S1/PPARG/RAB14/RAB8A/TBC1D1/CAB39L/PDPK1/RPS6KB1/PPP2R5E/STRADB/MAP3K7/CCNA2/RPS6KB2/PIK3R1/G6PC3/CAMKK2/PPP2R3C/CREB1	2.17697575976476
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	34/1353	169/9376	1.39415806207551	AMBRA1/RRAGA/RAB7A/GORASP2/MAP2K2/AKT1/HMGB1/EIF2S1/ATG3/UBB/MAPK3/BAD/ATG101/RHEB/AKT1S1/RAB8A/CTSD/ATG5/DAPK3/LAMP1/PDPK1/MTMR14/RPS6KB1/SH3GLB1/MAP3K7/MLST8/TANK/RAF1/YKT6/ATG4B/RPS6KB2/PIK3R1/CAMKK2/UVRAG	2.12334632642668
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/1353	41/9376	1.85921078722982	PGAM1/ALDH7A1/PHGDH/SHMT2/DLD/GRHPR/ALAS1/PSAT1/GLYCTK/GAMT/GCAT	2.26412619053238
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1353	68/9376	1.63053780270423	MAP2K2/AKT1/GRB2/CCND1/MAPK3/BAD/MYC/RPS6KB1/DUSP6/RAF1/CCNA2/RPS6KB2/PPARD/PIK3R1/NFKB1/TCF7L2	2.14290806051461
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	29/1353	142/9376	1.41523791678378	CAV1/HSP90AB1/GSTT1/GSTA4/PRKCZ/ASS1/GSTA3/CTNNB1/CALM3/TXN2/AKT1/SUMO3/SUMO1/MAPK13/GSTP1/MAPK14/GSTO1/TP53/RAC1/PDGFA/RHOA/MAP3K7/TXN/RAC3/PIAS4/PIK3R1/NFKB1/MAP2K5/BMP4	2.04744564488618
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1353	37/9376	1.87291504364675	PGM1/NANS/GPI/PMM2/GMDS/MPI/GNPNAT1/GFPT1/GMPPA/GALK2	2.18468482896469
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	30/1353	149/9376	1.39525885801872	NDUFV1/NDUFS8/NDUFB8/NDUFA10/NDUFAB1/NDUFS2/NDUFS7/NDUFB10/NDUFA8/NDUFB6/MAPK13/NDUFS6/NDUFA11/NDUFB9/MAPK3/NDUFS4/NDUFV2/NDUFC2/GNAI3/NDUFB5/NDUFB2/NDUFA9/NDUFA5/MAPK14/NDUFB11/NDUFB4/NDUFB7/KCNJ6/GNG5/PLCB3	1.99714972951667
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	25/1353	120/9376	1.44370534614437	ARHGDIA/CALM3/MAP2K2/AKT1/GRB2/RAP1A/MAPK13/MAGED1/MAPK3/BAD/BEX3/MAPK14/TP53/RAC1/PDPK1/RHOA/RAPGEF1/PTPN11/RAF1/IRAK1/SH2B2/PIK3R1/NFKB1/MAP2K5/PLCG2	2.00881411801244
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	17/1353	75/9376	1.57075141660507	GSTT1/GSTA4/GSTA3/CYCS/FADD/AKT1/GSTP1/MAPK3/BAD/GSTO1/TP53/PDPK1/BAK1/MSH6/BID/PIK3R1/ERCC1	2.03788159952228
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	16/1353	70/9376	1.58395100834125	FH/MAP2K2/AKT1/GRB2/RAP1A/MAPK3/BAD/PAK2/PRCC/RAC1/VHL/RAPGEF1/PTPN11/RAF1/PAK6/PIK3R1	2.01377084532366
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/1353	38/9376	1.82362780565605	PGM1/GPI/PMM2/MPI/HEXA/GNPNAT1/GNPDA1/GFPT1/GMPPA/GALK2	2.0891133477652
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	38/1353	200/9376	1.31665927568367	GAPDH/NCL/TUBA1C/TUBA1B/TUBB4B/CYCS/FADD/BRK1/ARPC5/ARPC2/CASP4/MAPK13/HCLS1/RPS3/NCK2/MAPK3/PAK2/GNA12/ABCF2/MAPK14/ARPC4/ROCK2/RAC1/ARPC5L/RHOA/ARPC3/MAP3K7/TUBB6/TRAF2/BAK1/PTPN11/PYCARD/TRADD/IRAK1/NFKB1/CASP7/PTPN6/CLDN19	1.85885986174838
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1353	44/9376	1.73244641537324	GNAS/ARHGDIA/DYNLL1/RAB5C/RAB11B/DCTN6/DCTN2/DYNC2LI1/DCTN1/DYNC1LI1/CREB1	1.99977424797315
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	17/1353	77/9376	1.52995267851144	CDK4/MAP2K2/AKT1/GRB2/CCND1/MAPK3/HDAC1/BAD/MYC/TP53/BAK1/PTPN11/RAF1/BCR/PIK3R1/NFKB1/RB1	1.91747835692895
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	18/1353	83/9376	1.50284508321534	HSD17B4/IDH1/IDH2/SCP2/PEX14/GSTK1/ACAA1/FAR2/ECI2/PMVK/PEX3/EPHX2/ACOX1/PEX16/ACOT8/ACOX3/PEX6/PEX19	1.88956321610333
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1353	30/9376	1.84794284306479	ATIC/SHMT2/DHFR/GART/ABCG2/GGH/FOLR2/NFKB1	1.91020711493935
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	27/1353	138/9376	1.35582762942254	CCNE1/ANAPC11/CALM3/PPP1CC/PPP1CA/ANAPC13/MAPK13/YWHAB/YWHAH/MAPK3/PPP2R1A/ANAPC4/MAD2L2/CUL1/ANAPC15/MAPK14/CDC26/CCNB2/CDC23/PPP2R5E/CDC16/MAD2L1/CDC20/PPP3CB/ANAPC7/FBXO5/ANAPC1	1.72924437616099
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1353	41/9376	1.69019162475439	CDK4/MAP2K2/CCND1/MAPK3/RASSF1/MYC/TP53/DAPK3/RAF1/RB1	1.81873989167516
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	32/1353	170/9376	1.30443024216338	GSTT1/GSTA4/GSTA3/CTNNB1/CDK4/TXNRD1/MAP2K2/AKT1/GRB2/BRD7/CCND1/GSTP1/MAPK3/BAD/ACTL6A/MYC/SMARCC1/SMARCA4/GSTO1/TP53/TXNRD3/RPS6KB1/FRAT2/BAK1/RAF1/PBRM1/RPS6KB2/PIK3R1/PHF10/TCF7L2/RB1/PLCG2	1.64491290925177
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	22/1353	110/9376	1.3859571322986	HSP90AB1/ANAPC11/AKT1/ANAPC13/MAPK13/MAPK3/ANAPC4/MAD2L2/GNAI3/ANAPC15/MAPK14/CDC26/CCNB2/CDC23/KIF22/CDC16/RAF1/MAD2L1/CCNA2/PIK3R1/ANAPC7/ANAPC1	1.67207366152825
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1353	31/9376	1.78833178361109	PGM1/RPIA/PGLS/PFKL/RPE/GPI/ALDOA/GLYCTK	1.80537062186125
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	21/1353	106/9376	1.37288206501276	CCNE1/HSP90AB1/ETV5/CTNNB1/MAP2K2/AKT1/GRB2/CCND1/GSTP1/MAPK3/BAD/TP53/PDPK1/PDGFA/RAF1/FOLR2/PIK3R1/NFKB1/TCF7L2/CREB1/RB1	1.58544324880996
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	15/1353	71/9376	1.46403922425908	PGAM1/PKM/PDHA1/MAP2K2/AKT1/IDH1/IDH2/PFKL/MAPK3/PDHB/MYC/TP53/GLS/RAF1/PIK3R1	1.61172824976443
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1353	44/9376	1.57495128670295	GTF2H5/TAF7/GTF2I/TAF10/MNAT1/TBPL1/TBP/GTF2H3/TAF11/TAF6	1.56977050178022
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	15/1353	73/9376	1.42392856058075	MLLT1/PPIA/RAN/NELFCD/CPSF6/PSIP1/PIN1/FEZ1/CDK9/CHMP4B/NELFB/TNPO3/CHMP6/KAT2A/NELFA	1.49316821476472
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/1353	73/9376	1.42392856058075	CDK4/MAP2K2/AKT1/GRB2/CCND1/MAPK3/BAD/RASSF1/TP53/PDPK1/BAK1/RAF1/PIK3R1/RB1/PLCG2	1.49316821476472
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	31/1353	170/9376	1.26366679709578	YBX3/TUBA1C/TUBA1B/PRKCZ/HSPA4/CDK4/JAM3/ARPC5/ARPC2/AMOT/RAP1A/HCLS1/CCND1/RAB13/PPP2R1A/MYL12A/PCNA/RAB8A/ARPC4/RAP2C/ROCK2/RAC1/ARPC5L/VASP/MARVELD3/DLG3/ACTN1/RHOA/ARPC3/TJP3/CLDN19	1.42465779747055
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1353	28/9376	1.73244641537324	AKR1B1/PCBD1/MOCS2/DHFR/GGH/SPR/PCBD2	1.59390217073776
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1353	28/9376	1.73244641537324	ATP6V1C2/ATP6V1B2/ATP6V1D/ATP6V1F/ATP6V0D1/CA2/ATP6V1B1	1.59390217073776
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	23/1353	122/9376	1.30643500175687	CDK4/MAP2K2/AKT1/GRB2/MAPK13/NCK2/MAPK3/PPP2R1A/PAK2/MAPK14/PDPK1/PPP2R5E/RHOA/MAP3K7/PTPN11/RAF1/PAK6/PPP3CB/PIK3R1/NFKB1/PPP2R3C/BCL10/PTPN6	1.39900632550402
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1353	13/9376	2.13224174199784	XRCC6/XRCC5/MRE11/FEN1	1.67752679829151
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1353	98/9376	1.3435298731466	CFL1/AKT1/ARPC5/ARPC2/MAPK3/ARPC4/RAC1/ARPC5L/VASP/RPS6KB1/ARPC3/DNM2/DOCK1/RAF1/RPS6KB2/PIK3R1/MARCKSL1/PLCG2/PLD2	1.40383641341567
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	13/1353	63/9376	1.42995577141919	ECHS1/ALDH7A1/HADH/DLD/ACAT1/ALDH9A1/KMT5A/HADHA/DLST/ACAT2/ALDH3A2/GCDH/SETMAR	1.40609737228109
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	10/1353	46/9376	1.50647514380282	BLVRA/MMAB/UROS/HMBS/FECH/ALAS1/EPRS1/FXN/EARS2/HCCS	1.4140422008276
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/1353	35/9376	1.58395100834125	TPI1/AKR1B1/PFKL/PMM2/GMDS/MPI/ALDOA/GMPPA	1.42128080003507
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	30/1353	168/9376	1.2374617252666	PPIA/H2AZ1/HSP90AB1/PARP1/H2AZ2/MACROH2A1/H2AJ/VDAC1/SLC25A6/PPID/H2AX/FADD/CAPN1/HMGB1/CHMP1A/VDAC3/SLC25A5/SLC25A4/CHMP2B/GLUD1/VDAC2/SHARPIN/CHMP4B/PGAM5/AIFM1/TRAF2/PYCARD/BID/TRADD/CHMP6	1.27535692532039
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	16/1353	82/9376	1.35215329980351	NME1/GSTT1/GSTA4/GSTA3/DUT/NME4/CMPK1/GMPS/ITPA/GSTP1/NME6/GSTO1/TK1/UMPS/TPMT/HPRT1	1.31523541582974
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1353	19/9376	1.82362780565605	PDHA1/PDHB/DLD/DLST/OGDH	1.47572565055194
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	25/1353	138/9376	1.25539595316902	PRKCZ/CALM3/PPP1CC/PPP1CA/MAP2K2/AKT1/EIF4E/PRKAR1A/GRB2/RPS6/MAPK3/BAD/PTPN1/RHEB/PDPK1/RPS6KB1/RAPGEF1/EXOC7/RAF1/PPP1R3D/SH2B2/RPS6KB2/PHKG2/PIK3R1/G6PC3	1.24116841749621
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	25/1353	138/9376	1.25539595316902	MAP2K2/AKT1/ARPC5/ARPC2/MAPK13/MAPK3/RHOG/MAP2K3/MAPK14/ARPC4/ROCK2/RAC1/ARPC5L/RHOA/ARPC3/MAP3K7/TRAF2/DOCK1/PYCARD/IRAK1/RAC3/PIK3R1/NFKB1/PKN2/ARHGEF7	1.24116841749621
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	28/1353	157/9376	1.23588534090321	UQCRFS1/RAB17/RAB7A/MAP2K2/BSG/MAPK13/RAB5C/MAPK3/C1QA/PPARG/RAB14/MAPK14/RAC1/NR1H2/STAB1/PTPN11/DOCK1/C1QB/ITGB5/C1QC/XKR8/TGFBRAP1/SIRPA/PPARD/CASP7/DNMT3A/CREB1/PTPN6	1.22398194511153
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	37/1353	214/9376	1.19814051156654	CFL1/CALM3/CYCS/FADD/DDB1/AP1S3/MAP2K2/AKT1/MAPK13/AP1S1/MAPK3/BAD/GNAI3/CUL1/PAK2/MAP2K3/MAPK14/CCNB2/AP1B1/RAC1/RPS6KB1/MAP3K7/TRAF2/BAK1/RAF1/PAK6/BID/TRADD/IRAK1/RAC3/RPS6KB2/PPP3CB/PIK3R1/NFKB1/GNG5/AP1M1/PLCG2	1.20406841253981
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	16/1353	83/9376	1.33586229619142	UBE2D2/CBX4/PHC2/TFDP1/YY1/HDAC1/CBX3/USP7/MAX/UBE2D4/FOXK2/L3MBTL2/WDR5/TEX10/E2F6/ASXL1	1.26208460964015
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1353	71/9376	1.36643660930847	ATP6V1C2/JAM3/MAPK13/ATP6V1B2/ATP6V1D/ATP6V1F/ATP6V0D1/MAPK14/RAC1/PTPN11/ATP6V1B1/NFKB1/CSK/PLCG2	1.27272912308944
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/1353	54/9376	1.41162300511894	CENPX/RMI2/RPA3/RPA2/FANCF/UBE2T/RAD51/CENPS/ERCC1/ATRIP/FANCC	1.24568464171109
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1353	60/9376	1.3859571322986	MAP2K2/AKT1/MAPK13/MAPK3/BAD/MAPK14/RAC1/RAF1/RAC3/PPP3CB/PIK3R1/PLCG2	1.23158983720244
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/1353	31/9376	1.5647903106597	SRP54/SRP72/SRP9/UBL4A/SEC61B/OXA1L/SEC11A	1.29343489070834
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1353	15/9376	1.84794284306479	AK2/NTPCR/ACP1/NFS1	1.34963777817483
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1353	10/9376	2.07893569844789	ETHE1/TST/MPST	1.40179538670595
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	31/1353	180/9376	1.19346308614601	ALYREF/SRSF7/SRSF9/SRPK1/CYCS/FADD/SRSF2/PPP1CC/PPP1CA/SRSF6/SRSF4/AKT1/SRSF3/EIF2S1/BAD/RHEB/EIF2B1/TP53/MAP3K7/TRAF2/BAK1/PTPN11/EIF2B4/BID/TRADD/IRAK1/EIF2B5/PIK3R1/NFKB1/EIF2B3/POU2F1	1.07621991211833
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	40/1353	238/9376	1.16466985907445	RPS10/RPL18A/RPLP0/RPS4Y1/RPL10/RPS5/RPS26/RPL4/RPS2/RPS6/MAPK13/RPL8/RPS3/RPL13/MAPK3/RPL19/RPL26L1/RPS8/C1QA/RPS24/RPS7/MAPK14/RPSA/RPL29/RPS14/RPL10A/RPL13A/RPLP1/MAP3K7/RPL23A/RPS13/C1QB/C1QC/F13A1/IRAK1/RPS16/PIK3R1/NFKB1/RPL15/PLCG2	1.05667919312533
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/1353	174/9376	1.19479063129189	HSP90AB1/VCP/BAG2/RAD23A/DNAJA2/UBE2D2/CAPN1/RAD23B/EIF2S1/NSFL1C/BCAP31/UBE2J1/CUL1/UFD1/SEC13/SVIP/HSPBP1/STUB1/UBE2J2/UBE2G2/SEC61B/NGLY1/SEC23B/PREB/TRAF2/BAK1/PRKCSH/DDOST/UBE2D4/PLAA	1.06504440482447
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1353	38/9376	1.45890224452484	PNP/QPRT/NMRK1/NT5C/NT5C2/NADK/SIRT5/NADK2	1.16399519026997
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1353	21/9376	1.64994896702214	AASDHPPT/BCAT2/PANK2/COASY/ALDH3A2	1.22442771044219
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	18/1353	99/9376	1.25996102936236	MAP2K2/AKT1/GRB2/MAPK3/RHEB/LYPLA1/SLC44A1/RAC1/PDPK1/PDGFA/RPS6KB1/RAF1/CHKA/RAC3/RPS6KB2/PIK3R1/DGKD/PLD2	1.06779579769839
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/1353	93/9376	1.26673501339119	CTNNB1/CTNNA1/RAP1A/MAPK3/PTPN1/MYL12A/ROCK2/RAC1/ACTN1/ACP1/RHOA/MAP3K7/CCM2/CSNK2A2/RAC3/TCF7L2/PTPN6	1.06155736367106
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/1353	93/9376	1.26673501339119	CCNE1/CDK4/CKS1B/CYCS/LAMC2/AKT1/SKP2/CCND1/MYC/TRAF4/TP53/MAX/TRAF2/BAK1/PIK3R1/NFKB1/RB1	1.06155736367106
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	16/1353	87/9376	1.27444334004469	UQCRC2/CYC1/UQCRFS1/COX5A/UQCRH/COX5B/TPM3/COX7B/UQCRC1/COX6A1/COX7A2L/TNNC1/UQCR10/COX8A/COX4I1/UQCRQ	1.05607310217046
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1353	27/9376	1.53995236922066	ECHS1/ACADS/HADH/ACAT1/HADHA/ACAT2	1.15377438705811
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/1353	69/9376	1.30561179129578	MAP2K2/AKT1/GRB2/MAPK13/MAPK3/MAP2K3/MAPK14/RAC1/PDPK1/RAF1/RAC3/PIK3R1/PLCG2	1.04629930115314
Human Diseases	Cancer: specific types	hsa05214	Glioma	14/1353	76/9376	1.27653946395923	CALM3/CDK4/MAP2K2/AKT1/GRB2/CCND1/MAPK3/TP53/PDGFA/BAK1/RAF1/PIK3R1/RB1/PLCG2	0.994005022812163
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1353	22/9376	1.57495128670295	ALDH7A1/CNDP2/ALDH9A1/HNMT/ALDH3A2	1.10868927982846
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	15/1353	83/9376	1.25237090267945	POLR2E/FADD/G3BP1/POLR2H/POLR2F/POLR1D/POLR3H/ZCCHC3/POLR3K/PYCARD/DDX41/POLR1C/NFKB1/CASP7/POLR3B	0.948345306408552
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	16/1353	90/9376	1.23196189537653	AKT1/EIF4E/ATG101/RHEB/AKT1S1/PPARG/TP53/ATG5/RPS6KB1/APPL1/ATF2/RPS6KB2/PIK3R1/NFKB1/CAMKK2/CREB1	0.908008061270563
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1353	122/9376	1.19283195812584	CTNNB1/MAP2K2/AKT1/PFKL/HDAC3/CCND1/MAPK3/HDAC1/BAD/RHEB/MYC/TP53/PDPK1/RAF1/MED27/PIK3R1/KAT2A/PLCB3/BMP4/MED24/PLCG2	0.880360035996854
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1353	17/9376	1.63053780270423	TXNRD1/SEPHS1/SEPHS2/TXNRD3	1.06853070499985
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/1353	78/9376	1.24380768283207	CFL1/CALM3/MAPK13/MAPK3/GNAI3/C1QA/MAPK14/RHOA/C1QB/PYCARD/C1QC/IRAK1/NFKB1/CASP7	0.887904092524033
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1353	23/9376	1.50647514380282	ASS1/GOT1/GLUD1/GOT2/GLS	0.998648669321463
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1353	23/9376	1.50647514380282	MDH1/GLUD1/GLS/CA2/SLC25A10	0.998648669321463
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	37/1353	227/9376	1.12952453513322	GNAS/CTNNB1/CALM3/CDK4/CYCS/FADD/MAP2K2/AKT1/GRB2/MAPK13/CCND1/MAPK3/GNAI3/RHEB/MYC/GNA12/MAPK14/TP53/ROCK2/RAC1/RPS6KB1/RHOA/ATF2/TRAF2/BAK1/RAF1/BID/TRADD/RAC3/RPS6KB2/PPP3CB/PIK3R1/NFKB1/GNG5/PLCB3/CREB1/RB1	0.811230550265262
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	32/1353	195/9376	1.13719559573218	H3-3A/H2AZ1/PPIF/H4C3/H3-3B/H2AZ2/MACROH2A1/H2AJ/VDAC1/SLC25A6/H2AX/MAP2K2/AKT1/CASP4/HMGB1/MAPK13/HDAC3/VDAC3/MAPK3/HDAC1/SLC25A5/SLC25A4/HAT1/VDAC2/MAPK14/RAC1/MAP3K7/RAF1/PIK3R1/NFKB1/PLCB3/PLCG2	0.795021039860154
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/1353	156/9376	1.1549642769155	CTNNB1/CDK4/CYCS/FADD/MAP2K2/AKT1/GRB2/YWHAB/EIF2S1/CCND1/YWHAH/MAPK3/BAD/PPP2R1A/PSME3/MYC/TP53/TRAF2/BAK1/RAF1/BID/TRADD/PIK3R1/NFKB1/RB1/CLDN19	0.8014834762631
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	27/1353	163/9376	1.14787860650497	CCNE1/CYCS/FADD/DDB1/MAP2K2/AKT1/GRB2/MAPK13/YWHAB/VDAC3/MAPK3/BAD/MYC/MAP2K3/PCNA/MAPK14/TP53/ATF2/MAP3K7/RAF1/BID/CCNA2/IRAK1/PIK3R1/NFKB1/CREB1/RB1	0.782104449180837
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	24/1353	144/9376	1.1549642769155	ALDH7A1/CTNNB1/FADD/ADH5/AKT1/MAPK13/CCND1/ACADVL/C1QA/ALDH9A1/MAP2K3/MAPK14/ACADM/MAP3K7/ACOX1/C1QB/C1QC/ALDH3A2/TRADD/IRAK1/NFKB1/ACOX3/TCF7L2/CAMKK2	0.769539793879752
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/1353	99/9376	1.18996319439778	GNAS/CDK4/MAP2K2/AKT1/GRB2/MAPK13/CCND1/MAPK3/BAD/MAPK14/TP53/RPS6KB1/CARM1/RAF1/RPS6KB2/PIK3R1/RB1	0.780278110118475
NA	NA	hsa04981	Folate transport and metabolism	6/1353	31/9376	1.34124883770832	SHMT2/MTHFD1/DHFR/ABCG2/ST20-MTHFS/FOLR2	0.781499159555425
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/1353	109/9376	1.14436827437499	PRKCZ/PPP1CC/PPP1CA/AKT1/PTPN1/NR1H2/PDPK1/RPS6KB1/GFPT1/PTPN11/MLX/PPP1R3D/RPS6KB2/PIK3R1/NFKB1/G6PC3/CREB1/PTPA	0.622560515783798
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1353	51/9376	1.22290335202817	GNAS/ATP6V1C2/ATP6V1B2/ATP6V1D/ATP6V1F/ATP6V0D1/SEC61B/ATP6V1B1/PLCG2	0.655455795271375
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1353	32/9376	1.29933481152993	PGM1/AKR1B1/PFKL/GLA/G6PC3/GALM	0.696517353647244
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/1353	32/9376	1.29933481152993	CYCS/FADD/BAK1/HTRA2/BID/CASP7	0.696517353647244
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/1353	90/9376	1.1549642769155	MAP2K2/AKT1/MAPK13/MAPK3/MAP2K3/MAPK14/RPS6KB1/PTPN11/RAF1/CSNK2A2/RPS6KB2/PPP3CB/PIK3R1/NFKB1/PTPN6	0.606603133759666
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	18/1353	110/9376	1.13396492642612	GAPDH/ENO1/PDHA1/PGK1/MAP2K2/AKT1/EIF4E/RPS6/PFKL/MAPK3/PDHB/VHL/RPS6KB1/ALDOA/RPS6KB2/PIK3R1/NFKB1/PLCG2	0.580373327244007
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	32/1353	203/9376	1.09238000575259	CAV1/CCND3/SPP1/CTNNB1/LAMC2/PPP1CC/PPP1CA/AKT1/TLN1/GRB2/RAP1A/CCND1/MAPK3/BAD/PARVA/MYL12A/PAK2/VEGFB/ROCK2/RAC1/VASP/PDPK1/PDGFA/ACTN1/RHOA/RAPGEF1/DOCK1/ITGB5/RAF1/PAK6/RAC3/PIK3R1	0.546432406530191
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1353	20/9376	1.3859571322986	NANS/NPL/GMDS/GMPPA	0.70953709010259
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/1353	86/9376	1.12810464256862	MAP2K2/AKT1/GRB2/NCK2/MAPK3/BAD/PAK2/MYC/RPS6KB1/RAF1/PAK6/RPS6KB2/PIK3R1/PLCG2	0.490086092107519
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	26/1353	166/9376	1.08538811565553	PPIF/VDAC1/SLC25A6/CALM3/PPP1CC/PPP1CA/MAP2K2/AKT1/VDAC3/MAPK3/BAD/SLC25A5/SLC25A4/GNAI3/GNA12/VDAC2/GTF2I/ROCK2/VASP/RHOA/ATF2/RAF1/PPP3CB/PLCB3/CREB1/ADRA2C	0.455814145762067
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/1353	73/9376	1.1391428484646	CDK4/MAP2K2/AKT1/CCND1/MAPK3/BAD/TP53/PDGFA/BAK1/RAF1/PIK3R1/RB1	0.490091251116799
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/1353	80/9376	1.12609016999261	MAP2K2/AKT1/EIF4E/GRB2/RPS6/MAPK3/BAD/PDGFA/RPS6KB1/RAF1/RPS6KB2/PIK3R1/PLCG2	0.465097822898898
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/1353	107/9376	1.10099398360169	GNAS/PGAM1/PKM/PRMT1/CALM3/PPP4C/PDHA1/AKT1/PFKL/PDHB/ATF2/PHKG2/PPP3CB/G6PC3/PLCB3/CREB1/SIK1	0.431456574370196
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	28/1353	181/9376	1.07201104155692	NFYB/HSPD1/HSPA9/RAB7A/CALM3/CYCS/FADD/AKT1/MAPK13/RAB5C/RFXANK/MAPK3/BAD/NFYC/ATP6V0D1/CTSD/MAPK14/LAMP1/RHOA/RAF1/BID/TRADD/IRAK1/MRC1/PPP3CB/NFKB1/BCL10/CREB1	0.401724809594219
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/1353	216/9376	1.05871725383921	HSP90AB1/HSPD1/HSPA4/CALM3/CYCS/AKT1/RAP1A/MAPK13/EIF2S1/MAPK3/BAD/PPARG/CYP2J2/MAP2K3/MAPK14/TP53/ROCK2/RAC1/PDPK1/RHOA/MAP3K7/TRAF2/TANK/PYCARD/BID/IRAK1/PPP3CB/PIK3R1/NFKB1/CASP7/PLCB3/POU2F1/CASP6	0.358518041165307
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	12/1353	75/9376	1.10876570583888	CCNE1/CCND3/SHISA5/CDK4/CYCS/SIAH1/CCND1/TP53/CCNB2/SIVA1/ZNF385A/BID	0.388350557071799
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1353	42/9376	1.1549642769155	GSS/VDAC3/VDAC2/TP53/ATG5/LPCAT3/GCLM	0.413321961213096
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/1353	89/9376	1.09007864338092	GNAS/TUBA1C/TUBA1B/TUBB4B/MAP2K2/GRB2/MAPK3/GNAI3/CSNK1D/PDGFA/TUBB6/RAF1/MAP2K5/PLCB3	0.350626920886233
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1353	29/9376	1.19479063129189	RASSF1/TEAD3/STK3/FRMD6/TPTEP2-CSNK1E	0.431416829735155
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1353	16/9376	1.29933481152993	HEXA/GLA/NAGA	0.492091013380349
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1353	76/9376	1.09417668339363	PLIN2/CPT2/SCP2/ACAA1/PPARG/PLTP/ACADM/PDPK1/ACOX1/PPARD/ACOX3/ANGPTL4	0.338512612213848
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1353	23/9376	1.20518011504226	ATP6AP2/ENPEP/PREP/NLN	0.404566445886526
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/1353	71/9376	1.07362876445666	MAP2K2/AKT1/GRB2/MAPK13/CCND1/MAPK3/MAPK14/RAF1/PIK3R1/NFKB1/ELF5	0.255731743064447
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1353	17/9376	1.22290335202817	HSD17B4/SCP2/ACOT8	0.377739565919756
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1353	17/9376	1.22290335202817	CA8/GLUD1/CA2	0.377739565919756
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1353	17/9376	1.22290335202817	LAMP1/NRP2/PCDH11X	0.377739565919756
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	20/1353	133/9376	1.04207303180346	COMT/GNAS/CALM3/PPP1CC/PPP1CA/AKT1/MAPK13/PPP2R1A/GNAI3/ARRB1/GSK3A/MAPK14/PPP2R5E/ATF2/KCNJ6/PPP3CB/GNG5/PLCB3/PPP2R3C/CREB1	0.200673161580923
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1353	65/9376	1.06612087099892	SPP1/MAP2K2/AKT1/KCNN4/MAPK3/ARRB1/KCNJ6/RAF1/PIK3R1/PLCB3	0.219666191894036
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1353	79/9376	1.0526256701002	ATP6V1C2/AP2M1/NAPA/ATP6V1B2/ATP6V1D/ATP6V1F/ATP6V0D1/AP2A1/AP2S1/DNM2/ATP6V1B1/CLTC	0.192888310640949
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	29/1353	196/9376	1.02532542950661	CTNNB1/CALM3/CDK4/CYCS/FADD/MAP2K2/AKT1/MAPK13/ATG3/UBB/CCND1/MAPK3/MYC/MAPK14/TP53/RAC1/TRAF2/BAK1/RAF1/BID/TRADD/PPP3CB/PIK3R1/NFKB1/TCF7L2/GNG5/CREB1/RB1/PLCG2	0.147139628429299
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1353	52/9376	1.06612087099892	VDAC1/VDAC3/VDAC2/PLTP/LDLRAP1/VAPB/STARD3NL/ANGPTL4	0.196338399137511
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	30/1353	204/9376	1.01908612669014	CAV1/CTNNB1/PDCD4/PPP1CC/PPP1CA/EIF4B/MAP2K2/AKT1/GRB2/RPS6/MAPK13/HCLS1/CCND1/MAPK3/MYC/NUDT16L1/MAPK14/TP53/ROCK2/RAC1/PDPK1/RPS6KB1/RHOA/PTPN11/ITGB5/RAF1/RPS6KB2/PIK3R1/PTPN6/PLCG2	0.113179299947309
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1353	18/9376	1.1549642769155	MECR/CBR4/OXSM	0.270235541251646
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1353	18/9376	1.1549642769155	FUCA1/HEXA/AGA	0.270235541251646
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1353	18/9376	1.1549642769155	MMAB/CD320/THAP11	0.270235541251646
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1353	32/9376	1.08277900960828	ATG3/ATG101/ATG5/MLST8/ATG4B	0.192617144712324
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/1353	136/9376	1.01908612669014	CCNE1/RACK1/CCND3/CDK4/CYCS/FADD/AKT1/EIF2S1/CCND1/BAD/TP53/EIF3H/MAP3K7/BAK1/BID/TRADD/IRAK1/CSNK2A2/PIK3R1/NFKB1	0.0920698448353496
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/1353	178/9376	1.01221588313942	CCND3/CTNNB1/SIAH1/RUVBL1/CACYBP/CTNNBIP1/TBL1X/CCND1/CUL1/MYC/CBY1/TP53/ROCK2/RAC1/RHOA/LZTS2/MAP3K7/FRAT2/TLE3/CSNK2A2/RAC3/PPARD/PPP3CB/TCF7L2/PLCB3/TPTEP2-CSNK1E	0.0675700605995429
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	17/1353	116/9376	1.01557203659811	CTNNB1/CTNNA1/JAM3/RAP1A/MAPK13/MYL12A/GNAI3/MAPK14/ROCK2/RAC1/VASP/ACTN1/RHOA/PTPN11/PIK3R1/PLCG2/CLDN19	0.0693002908639063
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	15/1353	103/9376	1.00919208662519	GNAS/FADD/AKT1/MAPK13/MAPK3/PPP2R1A/GNAI3/C1QA/MAPK14/C1QB/C1QC/IRAK1/PIK3R1/NFKB1/PLCB3	0.0385202175573795
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	48/1353	333/9376	0.998888023278267	CCNE1/GNAS/PKM/CCND3/ATP6V1C2/SPP1/PRKCZ/CTNNB1/CDK4/FADD/LAMC2/MAP2K2/AKT1/GRB2/ATP6V1B2/CCND1/BCAP31/ATP6V1D/MAPK3/ATP6V1F/HDAC1/BAD/PPP2R1A/RHEB/ATP6V0D1/TUBG1/TP53/DLG3/RPS6KB1/PPP2R5E/TBPL1/BAK1/RBPJ/ATP6V1B1/ITGB5/RAF1/CCNA2/TRADD/TADA3/TBP/RPS6KB2/PIK3R1/NFKB1/TCF7L2/PPP2R3C/CREB1/MAML3/RB1	-0.00848452800511392
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1353	26/9376	1.06612087099892	PLAAT3/ACAA1/ACOX1/ACOX3	0.138639050313481
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	31/1353	217/9376	0.989969380213283	HSP90AB1/GNAS/GSTT1/CCND3/GSTA4/GSTA3/MAP2K2/AKT1/KPNB1/PTGES3/GRB2/CCND1/MAPK3/BAD/GNAI3/CDC6/MYC/ARRB1/GSTO1/RPS6KB1/EPHX2/ATF2/RAF1/KPNA6/RPS6KB2/PIK3R1/NFKB1/EPHX1/PAQR7/CREB1/RB1	-0.0613902987007569
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1353	34/9376	1.01908612669014	CUL1/CSNK1D/CRY1/CREB1/TPTEP2-CSNK1E	0.0457829180511761
Organismal Systems	Immune system	hsa04611	Platelet activation	18/1353	126/9376	0.989969380213283	GNAS/PRKCZ/PPP1CC/PPP1CA/AKT1/TLN1/RAP1A/MAPK13/MAPK3/MYL12A/GNAI3/MAPK14/ROCK2/VASP/RHOA/PIK3R1/PLCB3/PLCG2	-0.0465487813129271
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/1353	105/9376	0.989969380213283	CALM3/AKT1/MAPK13/MAPK3/MAPK14/RHOA/PTPN11/PYCARD/RAF1/PPP3CB/PIK3R1/NFKB1/BCL10/RELB/PLCG2	-0.0424448758939636
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	13/1353	91/9376	0.989969380213283	MAP2K2/AKT1/GRB2/MAPK3/RAC1/RAF1/RAC3/PPP3CB/PIK3R1/NFKB1/BCL10/PTPN6/PLCG2	-0.0394842280126177
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/1353	56/9376	0.989969380213283	VCP/HSPD1/CYCS/SEC22B/HBS1L/PYCARD/NFKB1/CASP7	-0.0309157627907145
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/1353	122/9376	0.965625870863776	CSH1/GNAS/MAP2K2/AKT1/GRB2/MAPK13/MAPK3/GNAI3/MAP2K3/MAPK14/ATF2/RAF1/PIK3R1/CSH2/PLCB3/CREB1/PLCG2	-0.156932543017472
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/1353	72/9376	0.962470230762914	FADD/MAPK13/PIN1/MAPK14/ATG5/MAP3K7/TRAF2/TANK/TRADD/NFKB1	-0.131272401946702
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1353	36/9376	0.962470230762914	DCXR/AKR1B1/AKR1A1/RPE/CRYL1	-0.0926445437133294
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/1353	94/9376	0.958374612759667	S100A9/HSP90AB1/FADD/MAPK13/ELAVL1/MAPK3/TRAF4/MAPK14/MAP3K7/TRAF2/TRADD/NFKB1/MAPK4	-0.166558795662967
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/1353	130/9376	0.959508783899028	GNAS/PRKCZ/MAP2K2/AKT1/GRB2/MAPK13/MAPK3/GNAI3/VEGFB/ARRB1/MAPK14/ATF2/RAF1/PIK3R1/NFKB1/GNG5/PLCB3/CREB1	-0.19090692942224
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	24/1353	173/9376	0.961357548415211	CCND3/VDAC1/SLC25A6/CDK4/CYCS/FADD/MAP2K2/AKT1/FDPS/NXT1/RAB11B/EIF2S1/MAPK3/SLC25A5/SLC25A4/CPSF4/BAK1/PYCARD/RAF1/BID/TRADD/KPNA6/PIK3R1/NFKB1	-0.210663430666461
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1353	44/9376	0.94497077202177	ALG3/HEXA/FUT8/DDOST/ALG14/ALG2	-0.150244482991469
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1353	37/9376	0.936457521823375	COMT/ADH5/GOT1/FAHD1/GOT2	-0.159030697291396
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	32/1353	232/9376	0.955832505033514	PFN1/CFL1/CYRIB/PPP1CC/PPP1CA/MAP2K2/AKT1/BRK1/ARPC5/ARPC2/MAPK3/MYL12A/PAK2/GNA12/CYRIA/ARPC4/ROCK2/RAC1/ARPC5L/PDGFA/ACTN1/ENAH/RHOA/ARPC3/DOCK1/ITGB5/RAF1/PAK6/ITGAE/RAC3/PIK3R1/ARHGEF7	-0.279733701700474
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/1353	67/9376	0.93086673064831	CALM3/PPP1CC/PPP1CA/MAP2K2/RAP1A/MAPK3/RAF1/PPP3CB/PLCB3	-0.233205678940116
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1353	60/9376	0.923971421532397	GNAS/MAP2K2/MAPK3/PPP2R1A/GNAI3/GNA12/RAF1/PLCB3	-0.242607317605434
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/1353	155/9376	0.938874186395823	ATP6V1C2/TUBA1C/TUBA1B/TUBB4B/RAB7A/ATP6V1B2/RAB5C/ATP6V1D/ATP6V1F/SEC22B/STX18/ATP6V0D1/SEC61B/LAMP1/RAC1/M6PR/TUBB6/ATP6V1B1/ITGB5/MRC1/DYNC1LI1	-0.315113951127825
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1353	53/9376	0.915254710008507	GNAS/AP2M1/AP2A1/AP2S1/DNM2/CLTC/PLCB3	-0.25406322303954
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/1353	119/9376	0.93173588725956	FADD/AKT1/MAPK13/MAPK3/MAP2K3/MAPK14/RPS6KA4/PGAM5/ATF2/MAP3K7/TRAF2/TRADD/PIK3R1/NFKB1/CASP7/CREB1	-0.30774920457628
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1353	31/9376	0.894165891805546	ALDH7A1/AKR1A1/ALDH9A1/ALDH3A2	-0.242372302750404
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	21/1353	157/9376	0.926914005677405	CCND3/PRKCZ/CTNNB1/PPP1CC/PPP1CA/CTNNA1/AMOT/YWHAB/CCND1/YWHAH/PPP2R1A/RASSF1/MYC/CSNK1D/DLG3/TEAD3/STK3/TCF7L2/FRMD6/BMP4/TPTEP2-CSNK1E	-0.379234831417894
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/1353	62/9376	0.894165891805546	HDAC1/PSENEN/RBPJ/TLE3/NUMB/KAT2A/DTX4/MAML3	-0.343336142149303
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	25/1353	187/9376	0.926441933354676	HSP90AB1/VDAC1/TXN2/FADD/CASP4/MAPK13/TRIP6/VDAC3/MAPK3/VDAC2/MAPK14/SHARPIN/ATG5/SUGT1/CARD16/RHOA/BRCC3/MAP3K7/TXN/TRAF2/TANK/PYCARD/NFKB1/PLCB3/PKN2	-0.417237297627751
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1353	24/9376	0.866223207686622	GLCE/HS6ST2/EXT2	-0.269463713447209
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1353	16/9376	0.866223207686622	GOT1/GOT2	-0.219922156597143
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/1353	93/9376	0.894165891805546	GNAS/CALM3/MAP2K2/GRB2/MAPK13/MAPK3/MAP2K3/MAPK14/RAF1/MAP3K4/PLCB3/PLD2	-0.421200709471963
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	13/1353	101/9376	0.891952609895136	PRKCZ/CDK4/AKT1/MAPK13/CCND1/MAPK3/VEGFB/MAPK14/RAC1/PIK3R1/NFKB1/PLCB3/PLCG2	-0.448315907444448
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/1353	56/9376	0.866223207686622	ALG3/DPM1/FUT8/DDOST/DPAGT1/ALG14/ALG2	-0.412318646903529
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/1353	56/9376	0.866223207686622	CCND1/CUL1/ARRB1/CSNK1D/KIF3A/SUFU/TPTEP2-CSNK1E	-0.412318646903529
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/1353	109/9376	0.890064213402768	SPP1/FADD/MAP2K2/AKT1/MAPK13/MAPK3/MAP2K3/MAPK14/TOLLIP/RAC1/MAP3K7/IRAK1/PIK3R1/NFKB1	-0.474077011056442
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1353	65/9376	0.852896696799136	AKR1B1/ALDH7A1/AKR1A1/ALDH9A1/ALDH3A2/GLA/GLYCTK/DGKD	-0.488705335259353
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/1353	133/9376	0.885762077032937	PRMT1/FOXO4/MAP2K2/AKT1/GRB2/MAPK13/SKP2/CCND1/MAPK3/USP7/MAPK14/CCNB2/PDPK1/RAF1/PIK3R1/G6PC3/TPTEP2-CSNK1E	-0.544873620739537
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	19/1353	149/9376	0.883663943411856	GNAS/MAP2K2/AKT1/GRB2/MAPK3/RALA/RHEB/GNA12/PDGFA/RHOA/DNM2/PTPN11/RAF1/PIK3R1/PLCB3/DGKD/RALB/PLCG2/PLD2	-0.587818638936216
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/1353	112/9376	0.866223207686622	PPIF/CYCS/LAMC2/AKT1/MAPK13/MAPK3/BAD/GNAI3/MAP2K3/MAPK14/PDPK1/MAP3K7/IRAK1/NFKB1	-0.584866379158
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1353	19/9376	0.729451122262419	HEXA/HYAL2	-0.484752840862832
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1353	36/9376	0.769976184610331	PGM1/GPI/GBE1/G6PC3	-0.567827936413644
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/1353	212/9376	0.882567041793917	PFN1/GNAS/PRKCZ/CTNNB1/CALM3/MAP2K2/AKT1/TLN1/RAP1A/MAPK13/MAPK3/RALA/GNAI3/VEGFB/MAP2K3/MAPK14/RAC1/VASP/PDGFA/ENAH/RHOA/RAPGEF1/RAF1/RAC3/PIK3R1/PLCB3/RALB	-0.710201412558962
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1353	69/9376	0.803453410028171	GNAS/CALM3/PPP1CC/PPP1CA/HDAC1/ATF2/PPP3CB/CREB1	-0.672901260974343
Human Diseases	Substance dependence	hsa05034	Alcoholism	24/1353	191/9376	0.870758407726866	H3-3A/H2AZ1/GNAS/H4C3/H3-3B/H2AZ2/MACROH2A1/H2AJ/CALM3/H2AX/PPP1CC/PPP1CA/GRB2/HDAC3/MAPK3/HDAC1/GNAI3/HAT1/SLC29A1/ATF2/RAF1/CAMKK2/GNG5/CREB1	-0.74104664200266
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/1353	139/9376	0.847527742772523	HSP90AB1/GNAS/KRT19/FKBP4/CALM3/MAP2K2/AKT1/GRB2/MAPK3/GNAI3/CTSD/ATF2/KCNJ6/RAF1/PIK3R1/PLCB3/CREB1	-0.74370191269912
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/1353	62/9376	0.782395155329852	AKT1/HDAC1/AKT1S1/ATG5/RPS6KB1/RPS6KB2/PIK3R1	-0.705931283937077
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	8/1353	70/9376	0.791975504170626	AKT1/APPL1/TRAF2/PTPN11/TRADD/NFKB1/G6PC3/CAMKK2	-0.717378099927076
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1353	79/9376	0.789469252575149	GSTT1/GSTA4/GSTA3/ADH5/AKR7A2/GSTP1/GSTK1/GSTO1/EPHX1	-0.771656116329472
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	18/1353	150/9376	0.831574279379157	CCNE1/CTNNB1/MAP2K2/AKT1/CTNNA1/GRB2/CCND1/MAPK3/MYC/TP53/RPS6KB1/FRAT2/BAK1/RAF1/RPS6KB2/PIK3R1/TCF7L2/RB1	-0.853912672932471
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/1353	104/9376	0.79959065324919	PISD/PLAAT3/LYPLA2/PHOSPHO1/LYPLA1/PCYT2/LPCAT3/CHKA/PTDSS1/GPD1L/DGKD/PLD2	-0.84394485711097
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/1353	143/9376	0.82382067304462	H3-3A/H2AZ1/H4C3/H3-3B/H2AZ2/MACROH2A1/SNRPD3/H2AJ/H2AX/SNRPD1/SNRPB/SSB/C1QA/ACTN1/C1QB/C1QC/RO60	-0.871801652525881
NA	NA	hsa03272	Virion - Hepatitis viruses	5/1353	48/9376	0.721852673072185	CHMP1A/LAMP1/CHMP4B/DPP4/CLDN19	-0.793354667212033
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/1353	105/9376	0.791975504170626	PARP1/UBE2I/MAP3K7/TRAF2/TRADD/IRAK1/CSNK2A2/PIAS4/NFKB1/BCL10/RELB/PLCG2	-0.880262047224074
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1353	49/9376	0.707120985866631	GNAS/GNAI3/ATF2/NFKB1/CREB1	-0.844075794112695
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/1353	99/9376	0.769976184610331	GNAS/CALM3/PPP1CC/PPP1CA/MAPK13/CYP2J2/MAP2K3/MAPK14/PIK3R1/PLCB3/PLCG2	-0.944828015360988
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/1353	115/9376	0.783367074777467	GNAS/GCM1/MAPK3/GNAI3/GNA12/ARRB1/MMP15/RHOA/ATF2/RAF1/PLCB3/CREB1/PLD2	-0.959865942591142
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	24/1353	201/9376	0.827437093909609	MLLT1/H3-3A/H3-3B/ETV5/HDAC1/MYC/PPARG/MYCN/CDK9/TP53/PRCC/FUT8/MAX/PDGFA/BAK1/DUSP6/CCNA2/ATF1/ETV7/NFKB1/ETV4/ETV6/TCF3/REL	-1.01556699592056
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	37/1353	300/9376	0.854673564917467	DUSP9/MAP2K2/AKT1/GRB2/RAP1A/MAPK13/MAP3K20/STMN1/MAPK3/PAK2/MYC/GNA12/VEGFB/ECSIT/ARRB1/MAP2K3/MAPK14/TP53/RAC1/MAX/PDGFA/RPS6KA4/STK3/ATF2/MAP3K7/TRAF2/DUSP6/RAF1/TRADD/IRAK1/MAP3K4/RAC3/PPP3CB/NFKB1/MAP2K5/PPP5C/RELB	-1.05056794249355
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/1353	194/9376	0.821572526878033	TUBA1C/TUBA1B/TUBB4B/DYNLL1/CAPZB/CAPZA1/DCTN6/DCTN2/MYL12A/TPM3/MYO7A/KIFC3/TUBG1/KIF2A/TNNC1/KIF22/TUBB6/KIF16B/DYNC2LI1/DCTN1/DYNC1LI1/KIF3A/ACTR1B	-1.03124079790447
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	17/1353	148/9376	0.795988893549869	CTNNB1/CDK4/MAP2K2/AKT1/GRB2/CCND1/MAPK3/MYC/TP53/RPS6KB1/FRAT2/BAK1/RAF1/RPS6KB2/PIK3R1/TCF7L2/RB1	-1.02729935730705
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/1353	110/9376	0.755976617617416	E2F4/TFDP1/MAPK3/HDAC1/PPP2R1A/E2F5/CUL1/MYC/RPS6KB1/RHOA/RPS6KB2/BMP4	-1.05717717418236
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1353	14/9376	0.494984690106641	FUT8	-0.776515955960103
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/1353	142/9376	0.780820919604843	AKT1/GRB2/MAPK13/MAPK3/PPARG/MAPK14/RAC1/MAP3K7/TRAF2/SIRPA/PPP3CB/PIK3R1/NFKB1/CREB1/RELB/PLCG2	-1.0807232082298
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1353	78/9376	0.710747247332613	ISYNA1/TPI1/IMPA2/PI4K2B/MTMR14/PLCB3/MTMR6/PLCG2	-1.05340693075743
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/1353	78/9376	0.710747247332613	MAPK13/MAPK3/MAPK14/MAP3K7/IRAK1/NFKB1/MARCKSL1/PTPN6	-1.05340693075743
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1353	70/9376	0.692978566149298	GSTT1/GSTA4/GSTA3/GSTP1/GSTK1/GSTO1/EPHX1	-1.05877171808342
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/1353	70/9376	0.692978566149298	CAV1/CYCS/SSPN/CCND1/RAC1/BID/RAC3	-1.05877171808342
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	28/1353	238/9376	0.815268901352115	FOXO4/PLAAT3/CALM3/MAP2K2/AKT1/GRB2/RAP1A/RAB5C/MAPK3/RALA/BAD/RASSF1/PAK2/VEGFB/RAC1/PDGFA/RHOA/PTPN11/RAF1/PAK6/RAC3/PIK3R1/NFKB1/GNG5/RALB/REL/PLCG2/PLD2	-1.1854112790377
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	21/1353	184/9376	0.790899450496481	CFL1/PRKCZ/NCK2/MAPK3/MYL12A/GNAI3/EPHB4/PAK2/ROCK2/RAC1/PDPK1/ENAH/RHOA/PTPN11/SEMA6D/RAF1/PAK6/RAC3/PPP3CB/PIK3R1/PLCG2	-1.17631928804199
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1353	15/9376	0.461985710766199	HEXA	-0.856336504148465
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1353	63/9376	0.659979586808855	PTGES/PLAAT3/PTGES2/PTGES3/CYP2J2/EPHX2	-1.11197904829116
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1353	63/9376	0.659979586808855	CTNNB1/TP53/BAK1/TCF7L2/SUFU/BMP4	-1.11197904829116
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/1353	154/9376	0.764976339255718	GNAS/CALM3/PPP1CC/PPP1CA/AKT1/MAPK13/MAPK3/PPP2R1A/GNAI3/TPM3/MAPK14/TNNC1/PPP2R5E/ATF2/PLCB3/PPP2R3C/CREB1	-1.20760674049514
NA	NA	hsa04518	Integrin signaling	17/1353	154/9376	0.764976339255718	CCND3/SPP1/CTNNB1/LAMC2/AKT1/TLN1/NCK2/CCND1/PARVA/VEGFB/RAC1/PDGFA/ACTN1/ITGB5/ITGAE/RAC3/PIK3R1	-1.20760674049514
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/1353	98/9376	0.707120985866631	CALM3/IMPA2/PI4K2B/MTMR14/PIP4P1/PIK3R1/PLCB3/MTMR6/DGKD/PLCG2	-1.19685144409625
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	17/1353	155/9376	0.760041008034714	CCNE1/GNAS/FH/CTNNB1/CDK4/MAP2K2/RAP1A/CCND1/MAPK3/GNAI3/ATF2/ASH2L/WDR5/TCF7L2/PLCB3/CREB1/RB1	-1.23702935974768
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1353	73/9376	0.664499994937683	GSTT1/GSTA4/GSTA3/ADH5/GSTP1/GSTK1/GSTO1	-1.1817036882964
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/1353	82/9376	0.676076649901754	HSP90AB1/NFYB/HSPA4/RFXANK/NFYC/PSME3/LGMN/CREB1	-1.20980113575862
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1353	47/9376	0.589768992467488	PKM/PRKCZ/MAPK3/PIK3R1	-1.1577799023795
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/1353	38/9376	0.547088341696814	MAPK3/PDPK1/PIK3R1	-1.14880020346811
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1353	48/9376	0.577482138457748	AKT1/PIK3R1/G6PC3/PLCB3	-1.20514017207142
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/1353	101/9376	0.686117392227028	GNAS/CTNNB1/CALM3/MAP2K2/MAPK3/GNAI3/RAF1/TCF7L2/PLCB3/CREB1	-1.30237820643513
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/1353	144/9376	0.721852673072185	DUSP9/CTNNB1/MAP2K2/AKT1/GRB2/MAPK13/DLX5/MAPK3/MYC/MAPK14/RAF1/PIK3R1/ISL1/TCF3/BMP4	-1.38125664116095
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	21/1353	193/9376	0.754018128970739	PRKCZ/AKT1/GRB2/RAP1A/MAPK3/BAD/GNAI3/ARRB1/GSK3A/ROCK2/RAC1/RHOA/RAF1/GRK6/RAC3/CCL28/PIK3R1/NFKB1/GNG5/PLCB3/PLCG2	-1.41793265141386
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/1353	59/9376	0.587269971312964	GNAS/PLAAT3/AKT1/GNAI3/PIK3R1	-1.30593080429742
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/1353	103/9376	0.672794724416794	SERPINB9/GNAS/SERPINB6/RAB7A/LAMC2/RAB5C/ACTN1/PIK3R1/NFKB1/PLCB3	-1.37118142107646
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1353	30/9376	0.461985710766199	PLAAT3/CYP2J2	-1.21201414887691
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/1353	154/9376	0.719977731064206	GNAS/CALM3/PPP1CC/PPP1CA/MAP2K2/CCND1/MAPK3/GNAI3/ROCK2/RHOA/KCNJ6/RAF1/PPP3CB/MAP2K5/CAMKK2/PLCB3	-1.43882015276556
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/1353	69/9376	0.602590057521128	GNAS/CALM3/GNAI3/PPP3CB/PLCB3/CREB1	-1.36058148582534
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1353	51/9376	0.54351260090141	PLAAT3/PAFAH1B1/PAFAH1B3/PLD2	-1.342318581058
NA	NA	hsa04517	IgSF CAM signaling	34/1353	299/9376	0.788002382912245	TUBA1C/TUBA1B/TUBB4B/DYNLL1/CTNNB1/MAP2K2/AKT1/JAM3/ARPC5/ARPC2/GRB2/RAP1A/MAPK13/NCK2/MAPK3/MYL12A/PAK2/MAPK14/ARPC4/RAC1/ARPC5L/PDPK1/ACTN1/RHOA/ARPC3/TUBB6/PTPN11/PAK6/NRP2/PIK3R1/CSK/PTPN6/TRIO/PLCG2	-1.5298947214614
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	42/1353	362/9376	0.804008281167694	CCNE1/CSH1/HSP90AB1/CCND3/SPP1/CDC37/CDK4/LAMC2/EIF4B/MAP2K2/AKT1/EIF4E/GRB2/RPS6/YWHAB/CCND1/YWHAH/MAPK3/BAD/PPP2R1A/RHEB/MYC/VEGFB/TP53/RAC1/PDPK1/PDGFA/RPS6KB1/PPP2R5E/ATF2/MLST8/ITGB5/RAF1/RPS6KB2/PIK3R1/CSH2/NFKB1/G6PC3/GNG5/PKN2/PPP2R3C/CREB1	-1.56170632943301
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/1353	140/9376	0.692978566149298	SPP1/CALM3/TFAM/MAP2K2/AKT1/RPS6/CCND1/MAPK3/GNAI3/RPS6KB1/RAF1/RPS6KB2/GNG5/PLCB3	-1.50299277088155
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1353	43/9376	0.483473418243696	ACAT1/GOT2/ACAT2	-1.39406303499509
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/1353	75/9376	0.554382852919438	GNAS/GPX3/ATF2/GPX7/PLCB3/CREB1	-1.59108669386877
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/1353	76/9376	0.547088341696814	GNAS/KCNJ15/CALM3/GNAI3/CA2/PLCB3	-1.6279646195811
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1353	23/9376	0.301295028760564	RXYLT1	-1.37768022441828
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/1353	86/9376	0.564052321284312	EMD/CTNNB1/CTNNA1/SSPN/LMNA/ITGB5/TCF7L2	-1.66779197022984
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/1353	97/9376	0.571528714349936	GNAS/CALM3/MAPK3/GNAI3/KCNJ6/GNG5/PLCB3/CREB1	-1.74189969376291
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/1353	133/9376	0.625243819082073	MAP2K2/GRB2/MAPK3/RAC1/PTPN11/RAF1/BID/RAC3/PPP3CB/PIK3R1/PTPN6/PLCG2	-1.78745159127364
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1353	38/9376	0.364725561131209	UNG/RFXANK	-1.61135928221572
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1353	26/9376	0.26653021774973	SLC52A3	-1.53790403103545
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/1353	52/9376	0.399795326624595	GNAS/CYP2J2/ACOT4	-1.78223944943654
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/1353	93/9376	0.521596770219902	MAPK13/MAPK3/MAPK14/RBPJ/PPP3CB/NFKB1/MAML3	-1.90395878261498
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/1353	65/9376	0.426448348399568	GNAS/ATF2/PLCB3/CREB1	-1.90544838956613
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1353	29/9376	0.238958126258379	CALM3	-1.68553420812789
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/1353	134/9376	0.568863002062856	GNAS/CALM3/PPP1CC/PPP1CA/MAP2K2/MAPK3/GNA12/ROCK2/RHOA/RAF1/PLCB3	-2.06419561357175
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/1353	55/9376	0.377988308808708	DEGS1/HEXA/GLA	-1.89983016421415
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/1353	30/9376	0.230992855383099	PGAP2	-1.73238435951295
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/1353	45/9376	0.307990473844132	ABCG2/ABCB7	-1.91082262787406
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/1353	226/9376	0.643918136687401	GNAS/CALM3/PPP1CC/PPP1CA/MAP2K2/AKT1/RAP1A/MAPK3/BAD/GNAI3/ROCK2/RAC1/RHOA/ACOX1/RAF1/RAC3/PIK3R1/NFKB1/ACOX3/CREB1/PLD2	-2.22515191721907
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/1353	91/9376	0.456908944713823	GNAS/GNAI3/ARRB1/KCNJ6/GRK6/GNG5	-2.13780718584593
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/1353	168/9376	0.577482138457748	CSH1/CCND3/AKT1/GRB2/CCND1/MYC/PDGFA/PTPN2/PTPN11/RAF1/PIAS4/PIK3R1/CSH2/PTPN6	-2.26925446694402
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/1353	102/9376	0.475573525788734	GNAS/RAP1A/RAB8A/RAC1/CA2/RHOA/PLCB3	-2.18684140560137
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/1353	105/9376	0.461985710766199	GNAS/EMD/SSPN/LMNA/TPM3/TNNC1/ITGB5	-2.27662399944093
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/1353	115/9376	0.482072046016903	AKT1/MAPK3/GNAI3/KCNJ6/PIK3R1/GNG5/PLCB3/CREB1	-2.29485616387078
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/1353	115/9376	0.482072046016903	GNAS/MAPK3/GNAI3/CYP2J2/KCNJ6/RAF1/GNG5/PLCB3	-2.29485616387078
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/1353	95/9376	0.437670673357451	ATP6V1C2/ATP6V1B2/ATP6V1D/ATP6V1F/ATP6V0D1/ATP6V1B1	-2.26214943308522
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/1353	116/9376	0.477916252516757	GNAS/MAPK3/GNAI3/GLS/PPP3CB/GNG5/PLCB3/PLD2	-2.32343119205747
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/1353	86/9376	0.40289451520308	GNAS/KCNN4/ATF2/PLCB3/CREB1	-2.28432855946908
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/1353	37/9376	0.187291504364675	PLCB3	-2.03400311829627
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/1353	98/9376	0.424272591519978	GNAS/CALM3/ATF2/ATF1/PLCB3/CREB1	-2.35271271410155
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/1353	99/9376	0.419987009787453	EMD/SSPN/LMNA/TPM3/TNNC1/ITGB5	-2.38241645326054
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1353	68/9376	0.305725838007043	ADH5/ALDH1A3/PNPLA4	-2.35951863878907
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/1353	44/9376	0.157495128670295	HSPD1	-2.30026321395609
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/1353	109/9376	0.381456091458329	HSP90AB1/MAPK13/MAPK3/MAPK14/PPP3CB/NFKB1	-2.66735206473692
NA	NA	hsa04519	Cadherin signaling	38/1353	404/9376	0.651811522615676	KRT19/CTNNB1/PPP1CC/PPP1CA/MAP2K2/BRK1/CTNNA1/ARPC5/ARPC2/MAPK13/YWHAB/PKP3/CIB2/YWHAH/MAPK3/MYO7A/MAP2K3/MAPK14/ARPC4/ROCK2/RAC1/ARPC5L/VASP/PSENEN/TEAD3/STK3/ACTN1/ENAH/RERE/RHOA/ARPC3/RAF1/FMN1/RAC3/PCDH11X/NFKB1/TCF7L2/TMC5	-2.93782948605746
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/1353	88/9376	0.31499025734059	C1QA/C1QB/C1QC/F13A1	-2.65120384829209
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/1353	89/9376	0.311451040965977	GNAI3/GLS/KCNJ6/GNG5	-2.68014473047297
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/1353	90/9376	0.307990473844132	GNAS/ABCG2/CA2/EPHX1	-2.7088510688602
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/1353	50/9376	0.13859571322986	CCL28	-2.5079014451301
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/1353	66/9376	0.209993504893727	COMT/HSD17B12	-2.64480665834408
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/1353	93/9376	0.298055297268515	GNAS/CALM3/KCNN4/PLCB3	-2.7936136265008
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/1353	99/9376	0.279991339858302	KRT19/C1QA/C1QB/C1QC	-2.95745182842036
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/1353	89/9376	0.233588280724482	SPP1/LAMC2/ITGB5	-2.98322189560888
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/1353	254/9376	0.491087172861707	GNAS/PPIF/VDAC1/TFEB/SLC25A6/CALM3/VDAC3/SLC25A5/SLC25A4/VEGFB/VDAC2/PDGFA/TNNC1/P2RX4/PHKG2/PPP3CB/PLCB3/PLCG2	-3.37661357514773
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/1353	61/9376	0.113603043631032	MT2A	-2.85212059352391
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/1353	66/9376	0.104996752446863	NFKB1	-2.99631783160173
NA	NA	hsa04382	Cornified envelope formation	13/1353	217/9376	0.41514844976686	S100A9/KRT19/S100A11/LAMC2/CAPN1/BLMH/PKP3/PPP2R1A/PPP2R5E/EPHX2/ELOVL1/PPP2R3C/CLDN19	-3.57946090349848
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/1353	103/9376	0.201838417325038	KCNN4/DPP4/COL14A1	-3.34476371516384
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	14/1353	233/9376	0.416381971076831	ENO1/EMD/PDLIM2/CAPZB/TLN1/SSPN/CAPZA1/CSRP2/LMNA/TPM3/LMNB2/TNNC1/ITGB5/LMNB1	-3.70449011731982
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/1353	323/9376	0.493452229765754	CCNE1/DNMT1/UBE2I/PDCD4/MAP2K2/GRB2/CCND1/STMN1/MAPK3/HDAC1/RASSF1/HNRNPK/MYC/TP53/GLS/PDGFA/RHOA/BAK1/RAF1/PIK3R1/NFKB1/DNMT3A/PLCG2	-3.80444709692294
NA	NA	hsa04081	Hormone signaling	11/1353	219/9376	0.348071425919739	CSH1/GNAS/GNAI3/GNA12/APPL1/RHOA/PIK3R1/CSH2/GNG5/PLCB3/ADRA2C	-4.00877431692662
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1353	86/9376	0.080578903040616	PLCB3	-3.51740173794757
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/1353	100/9376	0.0692978566149298	CCL28	-3.84234612706442
NA	NA	hsa04082	Neuroactive ligand signaling	7/1353	199/9376	0.243761304675632	GNAS/OGFRL1/GNAI3/P2RX4/GNG5/PLCB3/ADRA2C	-4.42793470808926
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/1353	160/9376	0.173244641537324	JAM3/VSIR/SIGLEC1/CLDN19	-4.33143615262544
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/1353	298/9376	0.093017257201248	CSH1/CCL28/CSH2/BMP4	-6.53398611175428
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/1353	370/9376	0.131104053055273	CSH1/OGFRL1/S1PR2/P2RX4/TMEM97/CSH2/ADRA2C	-7.00275290779742
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1353	449/9376	0.0308676421447349	CALM3/ARRB1	-8.64210697301664