category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	48/518	250/9376	3.47527413127413	CTSC/CTSZ/CTSB/CTSD/CTSL/CLTC/TPP1/AP2M1/LGMN/CLTA/NPC2/TLR7/VAMP8/AP1B1/FUCA1/AP2A2/SCARB2/LAMTOR1/HEXB/ACP5/ATP6V1F/MCOLN1/CD63/AP2S1/ATP6AP1/PLA2G15/MITF/LAMTOR2/HEXA/CLN6/SLC15A3/LAMP1/ACP2/ASAH1/GAA/MAN2B1/VPS29/VPS13C/PPT1/CTBS/CTSK/PSAP/RRAGD/ARSA/M6PR/CLTB/AP1S1/KXD1	9.59258719002373
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	48/518	308/9376	2.82083939226796	TUBA1B/MT-ND1/MT-CO3/MT-ATP6/CLTC/AP2M1/CLTA/AP2A2/COX8A/AP2S1/TUBB2A/UQCR11/GPX3/NDUFA13/NDUFA7/SLC25A6/NDUFB8/ATP5MC3/SLC25A5/PSMA2/COX4I1/PSMA1/POLR2F/POLR2J/BAX/MT-CO1/TUBB/DCTN4/ATP5F1B/UQCR10/NDUFS3/SDHD/UQCRC2/ATP5PD/TUBA1C/NDUFA11/PSMD2/NDUFS2/PSMB7/UQCRQ/NDUFA6/PSMB5/NDUFS6/GRIA4/NDUFV3/HIP1/PSMC1/CLTB	7.85731063339192
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	44/518	275/9376	2.89606177606178	TUBA1B/MT-ND1/C1QA/MT-CO3/MT-ATP6/EGR1/C1QB/C1QC/COX8A/NCF4/TUBB2A/NCF2/UQCR11/NDUFA13/NDUFA7/SLC25A6/NDUFB8/ATP5MC3/SLC25A5/PSMA2/COX4I1/PSMA1/BAX/MT-CO1/TUBB/ATP5F1B/UQCR10/NDUFS3/SDHD/UQCRC2/ATP5PD/RAC1/TUBA1C/MAPK3/NDUFA11/PSMD2/NDUFS2/PSMB7/UQCRQ/NDUFA6/PSMB5/NDUFS6/NDUFV3/PSMC1	7.7171501973533
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	43/518	268/9376	2.90416642655449	TUBA1B/MT-ND1/MT-CO3/CALM3/MT-ATP6/COX8A/TUBB2A/UQCR11/GNAI2/NDUFA13/NDUFA7/SLC25A6/NDUFB8/ATP5MC3/SLC25A5/PSMA2/COX4I1/PSMA1/BAX/MT-CO1/TUBB/ATP5F1B/UQCR10/NDUFS3/UBE2L3/SDHD/UQCRC2/ATP5PD/TUBA1C/NDUFA11/PSMD2/NDUFS2/PSMB7/UQCRQ/TXN2/NDUFA6/PSMB5/XBP1/NDUFS6/SLC39A1/NDUFV3/PSMC1/UBE2L6	7.64792234777145
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	38/518	227/9376	3.03002058068137	EPHX1/MT-ND1/MT-CO3/JUN/MT-ATP6/CAT/COX8A/MGST2/NCF2/UQCR11/HMOX1/NDUFA13/NDUFA7/SLC25A6/FOS/NDUFB8/ATP5MC3/SLC25A5/CBR1/COX4I1/MT-CO1/ATP5F1B/AKR1A1/UQCR10/NDUFS3/SDHD/UQCRC2/ATP5PD/RAC1/MAPK3/NDUFA11/NDUFS2/UQCRQ/MAP2K2/NDUFA6/NDUFS6/NDUFV3/ABL1	7.48702418101896
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	29/518	155/9376	3.38652385103998	CD14/COLEC12/TUBA1B/CTSL/MRC1/ITGB2/FCGR2A/ITGB5/HLA-E/ATP6V1F/RAB5C/NCF4/HLA-A/TUBB2A/TLR4/NCF2/ATP6AP1/HLA-G/MARCO/STX7/ITGAM/LAMP1/SCARB1/TUBB/RAC1/TUBA1C/CANX/M6PR/HLA-B	7.24478159037227
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	34/518	205/9376	3.00201525567379	CTSD/MT-ND1/MT-CO3/MT-ATP6/PARP1/COX8A/GAPDH/NCF4/NCF2/UQCR11/TBC1D4/NDUFA13/NDUFA7/SLC25A6/NDUFB8/PDK4/ATP5MC3/SLC25A5/COX4I1/MT-CO1/ATP5F1B/UQCR10/NDUFS3/SDHD/UQCRC2/ATP5PD/RAC1/NDUFA11/NDUFS2/UQCRQ/PDHB/NDUFA6/NDUFS6/NDUFV3	7.00839621579502
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/518	250/9376	2.75125868725869	DAB2/FOLR2/SNX3/CLTC/AP2M1/CLTA/SNX2/HLA-E/ARPC1B/AP2A2/CAPZB/RAB5C/AP2S1/HLA-A/SNX5/VPS28/IL2RA/HLA-G/GRK3/ARPC5/CYTH4/WWP1/ARRB2/WASHC4/ARPC3/CHMP4A/CHMP3/VPS29/SPG21/VPS36/EPN1/ASAP2/ARPC4/RABEP1/EPS15/RUFY1/CLTB/HLA-B	6.78676411536213
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	26/518	138/9376	3.41021767108724	MT-ND1/MT-CO3/MT-ATP6/COX8A/ATP6V1F/ATP5MF/UQCR11/ATP6AP1/NDUFA13/NDUFA7/NDUFB8/ATP5MC3/COX4I1/MT-CO1/ATP5F1B/UQCR10/NDUFS3/SDHD/UQCRC2/ATP5PD/NDUFA11/NDUFS2/UQCRQ/NDUFA6/NDUFS6/NDUFV3	6.89746508258906
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	49/518	388/9376	2.28587350236835	TUBA1B/MT-ND1/DKK2/MT-CO3/CALM3/MT-ATP6/TNFRSF1A/COX8A/GAPDH/TUBB2A/UQCR11/NDUFA13/NDUFA7/SLC25A6/NDUFB8/ATP5MC3/SLC25A5/PSMA2/COX4I1/CASP7/CAPN1/PSMA1/MT-CO1/TUBB/ATP5F1B/UQCR10/RTN4/NDUFS3/SDHD/UQCRC2/ATP5PD/TUBA1C/MAPK3/NDUFA11/ADAM10/PSMD2/NCSTN/NDUFS2/PSMB7/UQCRQ/MAP2K2/NDUFA6/PSMB5/XBP1/NDUFS6/SLC39A1/NDUFV3/PSMC1/LRP1	6.25554651907692
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	26/518	157/9376	2.99751616949069	MT-CO3/JUN/TNFRSF1A/COX8A/UQCR11/CEBPA/NDUFA13/NDUFA7/FOS/NDUFB8/COX4I1/CASP7/BAX/MT-CO1/UQCR10/NDUFS3/SDHD/UQCRC2/RAC1/NDUFA11/NDUFS2/UQCRQ/NDUFA6/XBP1/NDUFS6/NDUFV3	6.10352745326337
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	30/518	200/9376	2.71505791505791	TUBA1B/JUN/FCGR2A/CYFIP1/ARPC1B/TNFRSF1A/GAPDH/TUBB2A/TLR4/ARPC5/CYTH4/IL18/NAIP/TNFSF10/FOS/CASP7/ARPC3/PAK2/BAX/TUBB/MYO5A/BRK1/PTPN6/RAC1/TUBA1C/MAPK3/ROCK2/NCK2/ARPC4/ABL1	5.92856745498535
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	34/518	248/9376	2.48150454602067	CD14/TUBA1B/JUN/CYFIP1/ARPC1B/TNFRSF1A/GAPDH/RAB5C/TUBB2A/TLR4/DYNLRB1/ARPC5/LY96/CYTH4/RHOB/IL18/NAIP/TNFSF10/FOS/CASP7/ARPC3/BAX/TUBB/DCTN4/BRK1/PKN1/RAC1/TUBA1C/MAPK3/ROCK2/MAP2K2/TXN2/M6PR/ARPC4	5.71773065578697
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	17/518	78/9376	3.94495594495594	CD14/C1QA/ITGB2/JUN/C2/CALM3/C1QB/C1QC/SERPING1/TLR4/GNAI2/LY96/C4BPB/FOS/ITGAM/CASP7/MAPK3	6.31559122817539
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	52/518	480/9376	1.96087516087516	TUBA1B/MT-ND1/DKK2/MT-CO3/CALM3/MT-ATP6/TNFRSF1A/CAT/COX8A/TUBB2A/UQCR11/GPX3/NDUFA13/NDUFA7/SLC25A6/NDUFB8/ATP5MC3/SLC25A5/PSMA2/COX4I1/CASP7/CAPN1/PSMA1/BAX/MT-CO1/TUBB/DCTN4/ATP5F1B/UQCR10/NDUFS3/UBE2L3/SDHD/UQCRC2/ATP5PD/RAC1/TUBA1C/MAPK3/NDUFA11/PSMD2/NDUFS2/PSMB7/UQCRQ/MAP2K2/NDUFA6/PSMB5/XBP1/NDUFS6/GRIA4/NDUFV3/HIP1/PSMC1/UBE2L6	5.22604179263375
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	42/518	368/9376	2.06580493537015	TUBA1B/MT-ND1/MT-CO3/MT-ATP6/TNFRSF1A/CAT/COX8A/CHCHD10/TUBB2A/UQCR11/GPX3/NDUFA13/NDUFA7/NDUFB8/ATP5MC3/PSMA2/COX4I1/PSMA1/BAX/MT-CO1/TUBB/DCTN4/ATP5F1B/UQCR10/NDUFS3/SDHD/UQCRC2/ATP5PD/RAC1/TUBA1C/NDUFA11/PSMD2/NUP214/NDUFS2/PSMB7/UQCRQ/NDUFA6/PSMB5/XBP1/NDUFS6/NDUFV3/PSMC1	5.04394250700635
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	30/518	238/9376	2.28156127315791	RPS4Y1/F13A1/C1QA/JUN/C2/FCGR2A/ISG15/NRP1/RPS9/C1QB/MX1/TLR7/OAS1/RPS10/CFD/C1QC/TNFRSF1A/OAS2/HBEGF/IFIH1/TLR4/MX2/ADAR/FOS/RPS12/RPL17/OAS3/SYK/MAPK3/RPL23A	4.842670909778
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	21/518	137/9376	2.77451173801539	CTSC/CTSZ/CTSB/TUBA1B/CTSD/CTSL/JUN/PARP1/TNFRSF1A/TNFSF10/FOS/CASP7/CAPN1/BAX/SEPTIN4/PMAIP1/LMNA/TUBA1C/MAPK3/CTSK/MAP2K2	5.05952046121983
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	29/518	235/9376	2.23366466770722	MT-ND1/MT-CO3/MT-ATP6/FGFR1/COX8A/ATP5MF/UQCR11/NDUFA13/NDUFA7/NDUFAF3/NDUFB8/ATP5MC3/COX4I1/MT-CO1/ATP5F1B/UQCR10/NDUFS3/SDHD/COA6/UQCRC2/ATP5PD/NDUFA11/ADCY7/NDUFS2/UQCRQ/NDUFA6/NDUFS6/NDUFV3/MGLL	4.63144897150389
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	28/518	224/9376	2.26254826254826	ITGB2/JUN/EGR1/NRP1/CD4/CCND1/HLA-E/TNFRSF1A/HLA-A/IL2RA/SPI1/HLA-G/RB1/EGR2/NFATC2/SLC25A6/FOS/SLC25A5/ANAPC11/BAX/B2M/CCNE1/MAPK3/ADCY7/MAP2K2/CANX/ANAPC13/HLA-B	4.62483956920327
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	22/518	157/9376	2.53635983572289	STAB1/C1QA/ABCA1/C1QB/ITGB5/ADAM9/C1QC/RAB5C/PLA2G15/NFATC2/ALOX5/GAS6/CASP7/BSG/PTPN6/RAC1/MAPK3/ADAM10/SIRPA/MAP2K2/EPOR/LRP1	4.69443731102152
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/518	149/9376	2.55106112824234	MT-ND1/GNG10/GNG12/GNAI2/NDUFA13/NDUFA7/KCNJ5/NDUFB8/GNG7/GABRB2/NDUFS3/MAPK3/NDUFA11/ADCY7/NDUFS2/NDUFA6/GABRA3/NDUFS6/GRIA4/NDUFV3/MGLL	4.61502935658087
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/518	88/9376	3.08529308529309	F13A1/C1QA/ITGB2/C2/C1QB/CFD/C1QC/SERPING1/VSIG4/CR1/CFI/A2M/CFHR1/C4BPB/ITGAM	4.75258634579694
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	26/518	214/9376	2.19911232995345	JUN/CALM3/BST2/CD4/HLA-E/AP1B1/TNFRSF1A/GNG10/GNG12/HLA-A/TLR4/HLA-G/GNAI2/NFATC2/FOS/APOBEC3C/GNG7/PAK2/BAX/B2M/RAC1/MAPK3/MAP2K2/SAMHD1/AP1S1/HLA-B	4.29095827713322
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/518	142/9376	2.29441513948556	CSF1R/JUN/FCGR2A/TNFRSF1A/ACP5/NCF4/NCF2/SPI1/NFATC2/MITF/FOS/LILRB5/SYK/LILRB4/RAC1/MAPK3/CTSK/SIRPA	3.7584216486242
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	22/518	196/9376	2.03167599085966	JUN/CALM3/CCND1/HLA-E/TNFRSF1A/CCR1/GNG10/GNG12/HLA-A/HLA-G/RB1/NFATC2/FOS/GNG7/BAX/SYK/RAC1/MAPK3/MAP2K2/RCAN1/CD200R1/HLA-B	3.52965858286689
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/518	138/9376	2.22975770801858	FN1/JUN/FCGR2A/CD4/ARPC1B/TLR4/ARPC5/NFATC2/IL18/FOS/ARPC3/PKN1/RAC1/MAPK3/ROCK2/MAP2K2/ARPC4	3.51927170431732
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	24/518	227/9376	1.91369720885139	CALM3/CCL3/CCND1/HLA-E/CCL4/TNFRSF1A/CCR1/GNG10/GNG12/HLA-A/HLA-G/GNAI2/RB1/NFATC2/GNG7/BAX/B2M/RAC1/MAPK3/ADCY7/ROCK2/MAP2K2/EIF4EBP1/HLA-B	3.36985406054543
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/518	116/9376	2.34056716815338	IDH1/CAT/GAPDH/PGLS/MDH1/PFKL/PGAM1/PKM/SDHD/ECHS1/SHMT1/IDH2/GCSH/PDHB/ACADS	3.51313436423293
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/518	95/9376	2.47689494005283	CTSL/ITGB2/JUN/FLT1/CCL3/ACP5/ATP6V1F/TLR4/ATP6AP1/IL18/FOS/CD28/CTSK	3.49861939181692
NA	NA	hsa04517	IgSF CAM signaling	29/518	299/9376	1.75555584251236	PMP22/TUBA1B/ITGB2/CASK/NRP1/NRP2/FGFR1/ARPC1B/TUBB2A/ARPC5/DOK2/EPB41L1/ITGAM/CD84/PLXNA1/ARPC3/PAK2/TUBB/PTPN6/CD28/RAC1/TUBA1C/MAPK3/CABLES1/IQGAP1/MAP2K2/NCK2/ARPC4/ABL1	3.2108031083955
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/518	53/9376	3.07365046987688	CLTC/AP2M1/CLTA/AP2A2/ATP1B1/AP2S1/ATP2B4/CLTB/ATP1A1	3.66081959377214
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/518	18/9376	5.02788502788503	FUCA1/HEXB/HEXA/MAN2B1/MAN2B2	4.13622807177666
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/518	56/9376	2.90899062327634	CD14/ITGB2/CR1/TLR4/IL18/NAIP/ITGAM/CASP7/EEF1G	3.46475501955656
Human Diseases	Infectious disease: viral	hsa05162	Measles	16/518	136/9376	2.12945718828072	JUN/MX1/TLR7/CCND1/OAS1/OAS2/IFIH1/IL2RA/TLR4/MX2/ADAR/FOS/OAS3/BAX/CD28/CCNE1	3.20838090143338
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/518	78/9376	2.55261855261855	ITGB2/JUN/FCGR2A/NCF4/CR1/TLR4/NCF2/FOS/ITGAM/PTPN6/MAPK3	3.32966071306265
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/518	70/9376	2.5857694429123	ITGB2/CCND1/HLA-E/HLA-A/HLA-G/EIF4G1/CD28/RAC1/HLA-B/ABL1	3.22025468647316
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/518	71/9376	2.54935015498396	FGFR1/IDH1/PFKL/PGAM1/PKM/MAPK3/IDH2/MAP2K2/PDHB/LDHB	3.16886140919674
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/518	50/9376	2.89606177606178	HBA2/HBA1/ITGB2/GYPC/CR1/TLR4/IL18/LRP1	3.25066683062918
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/518	73/9376	2.47950494525837	BST2/CD4/MX1/MX2/PPIA/PIN1/CHMP4A/APOBEC3C/MLLT1/SAMHD1	3.06866175570846
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/518	109/9376	2.15876164500018	SPP1/CD14/JUN/CCL3/TLR7/CCL4/TLR4/LY96/FOS/RAC1/MAPK3/CTSK/MAP2K2	2.9425270180014
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/518	173/9376	1.88327716651416	RSAD2/MX1/TLR7/OAS1/TNFRSF1A/OAS2/IFIH1/TLR4/MX2/IL18/ADAR/SLC25A6/TNFSF10/SLC25A5/OAS3/BAX/MAPK3/MAP2K2	2.83555466583396
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/518	32/9376	3.39382239382239	TNFRSF1A/BIRC7/CASP7/BAX/SEPTIN4/PMAIP1	3.28007051130126
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/518	110/9376	2.13913653913654	FLT1/IGF1/GAPDH/TLR4/HMOX1/MKNK1/PFKL/EPAS1/MAPK3/MAP2K2/PDHB/EIF4EBP1/LDHB	2.90608730532447
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	22/518	232/9376	1.71641592331247	FN1/ITGB2/CYFIP1/SCIN/ITGB5/FGFR1/ARPC1B/PDGFC/GNG12/ARPC5/ENAH/ITGAM/ARPC3/IQGAP2/PAK2/BRK1/RAC1/MAPK3/IQGAP1/ROCK2/MAP2K2/ARPC4	2.6719221110856
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/518	181/9376	1.80003839672348	CD14/CTSD/MRC1/ITGB2/CALM3/FCGR2A/TNFRSF1A/RAB5C/FCER1G/CR1/TLR4/ATP6AP1/IL18/ITGAM/LAMP1/BAX/SYK/MAPK3	2.62819104739927
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/518	68/9376	2.39563933681581	CD14/CSF1R/CCND1/SPI1/CEBPA/ITGAM/MAPK3/MAP2K2/EIF4EBP1	2.79307212726772
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	16/518	156/9376	1.85644985644986	IFIT1/RSAD2/MX1/CCND1/OAS1/TNFRSF1A/OAS2/RB1/MX2/PPP2CB/OAS3/BAX/SCARB1/YWHAE/MAPK3/MAP2K2	2.60844365316837
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	18/518	184/9376	1.77068994460299	NRP1/EPHB3/GNAI2/NFATC2/ENAH/PLXNA1/PAK2/LRRC4/RAC1/MAPK3/PLXNB2/ROCK2/NCK2/ABLIM3/SEMA3D/SEMA4B/RGMA/ABL1	2.55309089278068
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/518	82/9376	2.20736415858367	CTSB/CTSL/CD4/LGMN/HLA-E/HLA-A/HLA-G/B2M/CANX/HLA-B	2.65537921569816
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/518	18/9376	4.02230802230802	PRDX1/TCN2/CD320/ABCD4	3.10360280814427
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	10/518	83/9376	2.18076940968507	HSD17B4/PRDX1/IDH1/CAT/SCP2/PRDX5/IDH2/PXMP2/FAR2/ABCD4	2.61281614529753
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	20/518	216/9376	1.67596167596168	CD14/JUN/CALM3/CCL3/ABCA1/TNFRSF1A/NCF4/TLR4/NCF2/LY96/NFATC2/IL18/TNFSF10/FOS/CASP7/BAX/RAC1/MAPK3/ROCK2/XBP1	2.43043434068991
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/518	38/9376	2.85795570006096	HEXB/AMDHD2/NAGK/GALE/HEXA/GNPDA1	2.77512722696858
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	19/518	205/9376	1.67759676052359	JUN/SCIN/CCND1/HLA-E/HLA-A/HLA-G/RB1/EGR2/BAX/PKM/SYK/CCNE1/PMAIP1/YWHAE/RAC1/MAPK3/PSMC1/MRPS18B/HLA-B	2.37204314943656
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/518	73/9376	2.23155445073253	CCND1/IGF1/FGFR1/PDGFC/RB1/MITF/BAX/MAPK3/MAP2K2	2.55438419124411
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/518	50/9376	2.53405405405405	CNDP2/LAP3/AOC1/GATM/GAMT/P4HA1/OAT	2.63002961868858
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/518	99/9376	2.01115401115401	JUN/CCND1/IGF1/HBEGF/RB1/FOS/CARM1/BAX/MAPK3/ADCY7/MAP2K2	2.44575983216248
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/518	99/9376	2.01115401115401	C1QA/ITGB2/C2/FCGR2A/C1QB/CFD/C1QC/PTAFR/CFI/KRT19/ITGAM	2.44575983216248
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/518	87/9376	2.08050414946967	MT-CO3/COX8A/ATP1B1/UQCR11/COX4I1/MT-CO1/UQCR10/UQCRC2/UQCRQ/ATP1A1	2.44841067315532
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/518	30/9376	3.01673101673102	IDH1/MDH1/SDHD/IDH2/PDHB	2.67533638942219
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/518	89/9376	2.03375124723439	TUBA1B/PDGFC/TUBB2A/GNAI2/HTR2B/TUBB/TUBA1C/MAPK3/ADCY7/MAP2K2	2.36949614892492
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/518	90/9376	2.01115401115401	JUN/CD4/TLR4/NFATC2/FOS/BATF/PTPN6/CD28/MAPK3/MAP2K2	2.33081016882772
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/518	103/9376	1.93305094275968	C1QA/JUN/CCL3/C1QB/C1QC/TNFRSF1A/TLR4/GNAI2/FOS/PPP2CB/MAPK3	2.3024834572372
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	15/518	157/9376	1.72933625162925	CALM3/CCND1/HLA-E/HLA-A/HLA-G/RB1/NFATC2/SLC25A6/SLC25A5/CAPN1/CCNE1/MAPK3/MAP2K2/EIF4EBP1/HLA-B	2.22852956209827
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/518	78/9376	2.08850608850609	FN1/CLTC/CLTA/ARPC1B/ARPC5/ARPC3/RAC1/ARPC4/CLTB	2.3343505413584
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/518	91/9376	1.98905341762485	JUN/NFATC2/FOS/LILRB5/SYK/LILRB4/PTPN6/RAC1/MAPK3/MAP2K2	2.29262049343634
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/518	91/9376	1.98905341762485	GNG10/GNG12/GNAI2/GRK3/KCNJ5/ARRB2/GNG7/GABRB2/ADCY7/GABRA3	2.29262049343634
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	13/518	133/9376	1.76921067146631	ITGB2/HLA-E/FCER1G/HLA-A/HLA-G/NFATC2/TNFSF10/SYK/PTPN6/RAC1/MAPK3/MAP2K2/HLA-B	2.16046544630554
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/518	44/9376	2.46823446823447	MAN1A1/HEXB/HEXA/MAN1C1/MGAT1/RPN2	2.36057100640931
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/518	44/9376	2.46823446823447	HLA-E/HLA-A/HLA-G/PTPRN2/CD28/HLA-B	2.36057100640931
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	18/518	205/9376	1.58930219418024	JUN/ISG15/CCND1/OAS1/HLA-E/OAS2/HLA-A/HLA-G/RB1/OAS3/BAX/SYK/B2M/CCNE1/RAC1/PSMD2/PSMC1/HLA-B	2.06295294501266
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/518	23/9376	3.14789323484976	ATP1B1/MDH1/CA2/ATP1A1	2.49392748242307
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/518	46/9376	2.36091992613732	PSMA2/PSMA1/PSMD2/PSMB7/PSMB5/PSMC1	2.23745004126277
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	10/518	97/9376	1.86601918560681	CALM3/GNG10/GNG12/GNAI2/KCNJ5/FOS/GNG7/MAPK3/ADCY7/GRIA4	2.07322039865608
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/518	59/9376	2.14750343563903	LAP3/HPGDS/IDH1/MGST2/GPX3/PRDX6/IDH2	2.13808335561984
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	12/518	125/9376	1.73763706563707	CTSD/TNFRSF1A/FCER1G/GNAI2/PPP2CB/ASAH1/BAX/RAC1/MAPK3/SGMS1/ROCK2/MAP2K2	2.00764109890199
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/518	139/9376	1.69284186550374	CTSD/JUN/CALM3/HBEGF/POMC/GNAI2/KRT19/KCNJ5/FOS/MAPK3/ADCY7/MAP2K2/FKBP5	1.99002590937698
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/518	98/9376	1.84697817350879	FCGR2A/SCIN/ARPC1B/ARPC5/ARPC3/SYK/RAC1/MAPK3/ASAP2/ARPC4	2.0381716319945
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	28/518	362/9376	1.40002986411826	SPP1/CSF1R/CSH1/FN1/FLT1/CCND1/IGF1/ITGB5/FGFR1/PDGFC/GNG10/GNG12/IL2RA/TLR4/LPAR6/VEGFB/PPP2CB/EIF4B/GNG7/SYK/CCNE1/YWHAE/PKN1/RAC1/MAPK3/MAP2K2/EPOR/EIF4EBP1	1.87702736052501
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/518	61/9376	2.07709348692955	FTL/ATP1B1/SLC40A1/HMOX1/ATP2B4/ATOX1/ATP1A1	2.04084286649381
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/518	87/9376	1.8724537345227	JUN/CCND1/FOS/BAX/PMAIP1/RAC1/MAPK3/MAP2K2/APPL1	1.97697069140184
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/518	37/9376	2.4459981216738	CCND1/NCOA4/BAX/MAPK3/MAP2K2	2.13108652613842
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/518	26/9376	2.78467478467479	TCN2/PLB1/SCARB1/ABCD4	2.203548614263
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/518	187/9376	1.54869613693143	CTSB/JUN/ANTXR1/OAS1/TXNIP/OAS2/TLR4/IFI16/IL18/NAIP/OAS3/YWHAE/PKN1/MAPK3/TXN2/SHARPIN	1.83274169494663
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/518	75/9376	1.93070785070785	IDH1/GAPDH/BCAT1/PFKL/PGAM1/PKM/SHMT1/IDH2	1.95686951156436
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/518	75/9376	1.93070785070785	CCND1/IGF1/SHISA5/BAX/CCNE1/PMAIP1/CCNG2/SESN1	1.95686951156436
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/518	39/9376	2.32056232056232	HLA-E/HLA-A/HLA-G/CD28/HLA-B	1.99834379189964
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/518	133/9376	1.63311754289198	CALM3/COMT/GNG10/GNG12/GNAI2/KCNJ5/FOS/PPP2CB/ARRB2/SCN1A/GNG7/GRIA4	1.77822360714336
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/518	17/9376	3.19418578242108	HSD17B4/SCP2/CYP27A1	2.18960518995893
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/518	52/9376	2.08850608850609	PLTP/ABCA1/NPC2/SCARB1/CYP27A1/LRP1	1.90332995240771
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/518	41/9376	2.20736415858367	GATM/PGAM1/GAMT/SHMT1/GCSH	1.87350875407841
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/518	41/9376	2.20736415858367	CCND1/HBEGF/RB1/MAPK3/MAP2K2	1.87350875407841
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/518	122/9376	1.63200202544465	JUN/CD4/NFATC2/FOS/PPP2CB/PAK2/PTPN6/CD28/MAPK3/MAP2K2/NCK2	1.69908974223824
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/518	67/9376	1.89108511496571	GAPDH/PFKL/PGAM1/PKM/AKR1A1/PDHB/LDHB	1.77005905215676
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/518	168/9376	1.50836550836551	FTL/PARP1/TNFRSF1A/PYGL/TLR4/PPIA/SLC25A6/TNFSF10/SLC25A5/CHMP4A/CAPN1/CHMP3/BAX/SHARPIN	1.60779525447275
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/518	55/9376	1.97458757458757	HEXB/HEXA/ASAH1/SGMS1/PSAP/ARSA	1.75288587299683
NA	NA	hsa04518	Integrin signaling	13/518	154/9376	1.52795467081181	SPP1/FN1/ITGB2/FLT1/CCND1/IGF1/ITGB5/PDGFC/VEGFB/ITGAM/FERMT3/RAC1/NCK2	1.59744942740902
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/518	140/9376	1.55146166574738	SPP1/CALM3/EGR1/CCND1/KLF2/GNG10/GNG12/GNAI2/GNG7/MAPK3/ADCY7/MAP2K2	1.58971789919258
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/518	31/9376	2.3355336903724	CAT/MDH1/SHMT1/GCSH	1.80106224444039
NA	NA	hsa04981	Folate transport and metabolism	4/518	31/9376	2.3355336903724	FOLR2/ABCG2/SLCO2B1/SHMT1	1.80106224444039
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/518	57/9376	1.90530380004064	HSD17B4/SCP2/ACADVL/PPT1/ECHS1/ACADS	1.65779106812187
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/518	142/9376	1.52961009299037	CTSL/JUN/CALM3/TNFRSF1A/KLF2/MGST2/NCF2/HMOX1/FOS/SUMO3/RAC1/TXN2	1.53775862017187
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/518	204/9376	1.41963812552048	FN1/CTSL/CCND1/IGF1/ITGB5/FGFR1/HBEGF/CD63/TLR4/EIF4B/PTPN6/RAC1/MAPK3/IQGAP1/ROCK2/MAP2K2	1.46534767368795
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	9/518	100/9376	1.62903474903475	CSF1R/CCL3/CCL4/TNFRSF1A/CCR1/IL2RA/IL18/TNFSF10/IL34	1.52924457125463
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/518	45/9376	2.01115401115401	HLA-E/HLA-A/HLA-G/CD28/HLA-B	1.64415270483991
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/518	86/9376	1.68375684654754	JUN/HBEGF/PAK2/MAPK3/MAP2K2/NCK2/EIF4EBP1/ABL1	1.5403724294094
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/518	115/9376	1.57394661742488	EGR1/FGFR1/HBEGF/GNAI2/MAFB/MMP14/FOS/ARRB2/MAPK3/ADCY7	1.49752526739157
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/518	130/9376	1.53157113157113	JUN/GNG10/GNG12/GNAI2/VEGFB/FOS/ARRB2/GNG7/MAPK3/ADCY7/MAP2K2	1.47583837603145
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/518	33/9376	2.19398619398619	IDH1/BCAT1/IDH2/PDHB	1.66148253591517
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	19/518	253/9376	1.35931753323058	CD14/JUN/ARPC1B/TNFRSF1A/TLR4/ARPC5/CYTH4/IL18/NAIP/ARPC3/CAPN1/CAPNS1/BAX/RAC1/MAPK3/ROCK2/RRAGD/SHARPIN/ARPC4	1.40104638142504
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	18/518	238/9376	1.36893676389475	CSF1R/CALM3/FLT1/IGF1/FGFR1/RAB5C/PDGFC/RALBP1/GNG10/GNG12/RGL1/VEGFB/GNG7/PAK2/RAC1/MAPK3/MAP2K2/ABL1	1.39411151966089
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	24/518	333/9376	1.30453233155936	SPP1/FN1/ISG15/MX1/CCND1/ITGB5/HLA-E/TNFRSF1A/ATP6V1F/HLA-A/ATP6AP1/HLA-G/RB1/MX2/PPP2CB/BAX/PKM/CCNE1/MAPK3/MAP2K2/EIF4EBP1/DLG2/PSMC1/HLA-B	1.36830192825338
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/518	47/9376	1.92557298940278	MDH1/PKM/AKR1A1/PDHB/LDHB	1.53824224692901
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/518	22/9376	2.46823446823447	CNDP2/AOC1/HNMT	1.66721171414029
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/518	104/9376	1.56637956637957	PLD3/AGPAT2/PLA2G15/PLB1/CDS1/LYPLA1/SGMS1/ETNK1/MBOAT1	1.40449505651358
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/518	195/9376	1.39233739233739	ITGB2/FCGR2A/TLR7/NCF4/CR1/TLR4/NCF2/SLC25A6/SLC25A5/ITGAM/SYK/SIGLEC9/RAC1/MAPK3/MAP2K2	1.33879688531717
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	14/518	180/9376	1.40780780780781	BST2/OAS1/HLA-E/TNFRSF1A/OAS2/IFIH1/HLA-A/HLA-G/OAS3/BAX/SYK/B2M/EIF4EBP1/HLA-B	1.33590319272676
NA	NA	hsa03272	Virion - Hepatitis viruses	5/518	48/9376	1.88545688545689	CD63/CHMP4A/LAMP1/SCARB1/TGOLN2	1.48722422015178
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/518	76/9376	1.66714082503556	CALM3/ATP1B1/GNAI2/KCNQ1/ADCY7/CA2/ATP1A1	1.41210021664795
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/518	76/9376	1.66714082503556	CALM3/CCND1/IGF1/RB1/BAX/MAPK3/MAP2K2	1.41210021664795
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/518	212/9376	1.36606687550084	CSF1R/ITGB2/CALM3/FLT1/IGF1/FGFR1/PDGFC/GNAI2/VEGFB/ENAH/ITGAM/RAC1/MAPK3/ADCY7/SIPA1/MAP2K2	1.30367249462654
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	13/518	166/9376	1.4175001162953	CALM3/ATP1B1/GNAI2/ATP2B4/NFATC2/SLC25A6/SLC25A5/GTF2I/MAPK3/ADCY7/ROCK2/MAP2K2/ATP1A1	1.31239180489682
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/518	106/9376	1.53682523493844	FOLR2/CCND1/IGF1/FGFR1/PDGFC/RB1/CCNE1/MAPK3/MAP2K2	1.34409098582886
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/518	93/9376	1.55702246024827	JUN/CALM3/EGR1/HBEGF/MMP14/MAPK3/ADCY7/MAP2K2	1.30542728667346
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/518	154/9376	1.41041969613398	JUN/CALM3/CCND1/GNAI2/NFATC2/KCNJ5/FOS/MAPK3/ADCY7/ROCK2/MAP2K2/RCAN1	1.2418200743986
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/518	79/9376	1.60383167978105	CLTC/AP2M1/CLTA/AP2A2/ATP6V1F/AP2S1/CLTB	1.30328892462278
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/518	37/9376	1.95679849733904	HBA2/HBA1/APOL1/IL18	1.41011274865867
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/518	170/9376	1.38414717238247	TUBA1B/JUN/CCND1/ARPC1B/RAB13/ARPC5/PPP2CB/ARPC3/RAC1/TUBA1C/ROCK2/ARPC4/DLG2	1.22227603390863
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/518	51/9376	1.7745476569006	ENPP2/PLD3/PLA2G7/PLB1/TMEM86A	1.34119366185084
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/518	80/9376	1.58378378378378	IGF1/PDGFC/GAS6/BAX/MAPK3/MAP2K2/EIF4EBP1	1.26803617418411
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/518	38/9376	1.90530380004064	IGF1/ATP1B1/MAPK3/ATP1A1	1.35220297453188
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/518	98/9376	1.47758253880703	CALM3/ATP1B1/POMC/ATP2B4/KCNJ5/SCARB1/ADCY7/ATP1A1	1.1492565133053
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/518	83/9376	1.52653858677955	CCL4/IFI16/IL18/ADAR/CASP7/POLR2F/SAMHD1	1.16512886375223
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/518	54/9376	1.67596167596168	BCAT1/ADI1/MDH1/IL4I1/LDHB	1.20461172151991
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/518	54/9376	1.67596167596168	HLA-E/HLA-A/HLA-G/CD28/HLA-B	1.20461172151991
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/518	99/9376	1.46265746265746	JUN/PDGFC/FOS/LYPLA1/RAC1/MAPK3/MAP2K2/EIF4EBP1	1.11906695294263
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/518	69/9376	1.57394661742488	FCER1G/ALOX5/SYK/RAC1/MAPK3/MAP2K2	1.15710792804095
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/518	115/9376	1.41655195568239	GNG10/GNG12/GNAI2/KCNJ5/ALOX5/GNG7/HTR2B/GABRB2/MAPK3	1.08685557136749
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/518	70/9376	1.55146166574738	JUN/PAK2/EPAS1/RAC1/MAPK3/MAP2K2	1.11986456888204
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/518	85/9376	1.4906200317965	NME4/ADA2/CMPK2/ITPA/NUDT16/NME2/AK1	1.09876847172865
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/518	163/9376	1.33254376199161	JUN/IFIH1/TLR4/ATP6AP1/RB1/EGR2/NFATC2/FOS/BAX/CCNE1/MAPK3/MAP2K2	1.03567800301098
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/518	116/9376	1.40434030089202	ITGB2/CD99/NCF4/NCF2/GNAI2/ITGAM/RAC1/SIPA1/ROCK2	1.05962747682743
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/518	101/9376	1.43369394854543	FN1/JUN/EGR1/CCND1/VEGFB/BAX/RAC1/MAPK3	1.05966787935294
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/518	71/9376	1.52961009299037	JUN/ATP6V1F/HBEGF/ATP6AP1/RAC1/ADAM10	1.08320316114447
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/518	28/9376	1.93932708218423	CBR1/SPR/PCBD1	1.20370256998649
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/518	28/9376	1.93932708218423	ATP6V1F/SLC12A7/CA2	1.20370256998649
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/518	15/9376	2.41338481338481	HEXB/HEXA	1.32473072007204
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/518	42/9376	1.72384629527487	AOC1/CAT/IL4I1/ECHS1	1.13689349872658
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/518	42/9376	1.72384629527487	FTL/NCOA4/SLC40A1/HMOX1	1.13689349872658
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/518	103/9376	1.40585523109795	CD14/FN1/ITGB2/PRDX1/HSPB1/RAB5C/TLR4/ITGAM	1.00152618984802
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/518	43/9376	1.68375684654754	ABCA1/AGPAT2/SCARB1/SLC27A4	1.08669573603759
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/518	120/9376	1.35752895752896	JUN/CALM3/MAGED1/BAX/YWHAE/RAC1/MAPK3/MAP2K2/ABL1	0.953175460155095
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/518	16/9376	2.26254826254826	MIF/IL4I1	1.22222942654326
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/518	16/9376	2.26254826254826	HEXB/HEXA	1.22222942654326
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/518	89/9376	1.42362587306408	GNG10/GNG12/GNAI2/GNG7/GABRB2/ADCY7/GABRA3	0.971007171692131
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/518	201/9376	1.26072340997714	CD14/NUPR1/CSF1R/FLT1/IGF1/SPI1/CEBPA/HPGD/LYL1/MITF/ITGAM/BAX/HHEX/MLLT1	0.903561463007625
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/518	90/9376	1.40780780780781	IGF1/CAT/BAX/ADCY7/EIF4EBP1/SESN1/APPL1	0.940037397746131
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/518	90/9376	1.40780780780781	EPHX1/ABCG2/ATP1B1/SCARB1/ADCY7/CA2/ATP1A1	0.940037397746131
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/518	30/9376	1.81003861003861	FOLR2/ABCG2/SHMT1	1.07457353127143
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/518	122/9376	1.33527438445471	CCND1/ATP1B1/TBC1D4/DIO2/PFKL/MAPK3/MAP2K2/RCAN1/ATP1A1	0.901359876278015
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/518	45/9376	1.60892320892321	ABCA1/ABCG2/ABCA6/ABCD4	0.990118943254038
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/518	60/9376	1.50836550836551	HSPB1/NFATC2/RAC1/MAPK3/MAP2K2	0.955255709646627
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/518	60/9376	1.50836550836551	IGF1/GNAI2/PPP2CB/MAPK3/MAP2K2	0.955255709646627
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/518	17/9376	2.12945718828072	NRP2/LAMP1	1.12709932819229
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/518	76/9376	1.42897785003048	PLTP/FABP5/DBI/SCP2/CYP27A1/SLC27A4	0.907993773178134
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/518	31/9376	1.7516502677793	CNDP2/ECHS1/ACADS	1.01365388838923
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/518	46/9376	1.57394661742488	FTL/BLVRB/HMOX1/BLVRA	0.943609435189023
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/518	77/9376	1.41041969613398	CCND1/RALBP1/RB1/BAX/RAC1/MAPK3	0.874456304749663
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/518	77/9376	1.41041969613398	CCND1/RB1/BAX/MAPK3/MAP2K2/ABL1	0.874456304749663
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/518	93/9376	1.36239465271723	JUN/CD4/IL2RA/NFATC2/FOS/MAPK3/IL12RB2	0.849301243599363
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/518	32/9376	1.6969111969112	GALE/PFKL/GAA	0.954923753693352
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/518	32/9376	1.6969111969112	ECHS1/LDHB/ACADS	0.954923753693352
Organismal Systems	Immune system	hsa04611	Platelet activation	9/518	126/9376	1.29288472145615	FCGR2A/VAMP8/FCER1G/GNAI2/FERMT3/SYK/MAPK3/ADCY7/ROCK2	0.800375531577427
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/518	63/9376	1.43653857939572	HPGDS/HPGD/ALOX5/CBR1/PLB1	0.840680132787621
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	13/518	193/9376	1.21919699121772	CCL3/CCL4/CCR1/GNG10/GNG12/GNAI2/GRK3/ARRB2/GNG7/RAC1/MAPK3/ADCY7/ROCK2	0.744052586962333
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/518	160/9376	1.24440154440154	SIGLEC1/ITGB2/CD99/CD4/HLA-E/HLA-A/HLA-G/ITGAM/LRRC4/CD28/HLA-B	0.754007011389119
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/518	48/9376	1.50836550836551	BCAT1/IL4I1/ECHS1/ACADS	0.85385692872086
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/518	144/9376	1.25697125697126	CD14/C1QA/C2/C1QB/CCND1/C1QC/TNFRSF1A/TLR4/LY96/ACADVL	0.751450844933306
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	9/518	128/9376	1.2726833976834	NME4/ADA2/ITPA/NUDT16/NME2/ADCY7/NUDT2/AK1/PAPSS1	0.751142700398811
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/518	19/9376	1.90530380004064	HEXB/HEXA	0.955180635078498
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/518	19/9376	1.90530380004064	GCSH/PDHB	0.955180635078498
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/518	65/9376	1.39233739233739	SPP1/KCNJ5/ARRB2/MAPK3/MAP2K2	0.767539785309328
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	19/518	300/9376	1.14635778635779	CD14/CSF1R/JUN/FLT1/IGF1/FGFR1/TNFRSF1A/HSPB1/PDGFC/GNG12/VEGFB/MKNK1/FOS/ARRB2/PAK2/RAC1/MAPK3/MAP2K2/DUSP3	0.623034213168529
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/518	115/9376	1.2591572939399	GNG10/GNG12/GNAI2/FOS/KCNQ1/GNG7/MAPK3/ADCY7	0.676185875343405
NA	NA	hsa04519	Cadherin signaling	25/518	404/9376	1.12007339730112	CYFIP1/KRT7/FGFR1/ARPC1B/PCDH12/LHFPL2/ARPC5/MYO7A/KRT19/ENAH/DSC2/ARPC3/RERE/SCN1B/BRK1/GABRB2/YWHAE/RAC1/MAPK3/ADAM10/NCSTN/ROCK2/MAP2K2/GABRA3/ARPC4	0.596589394555219
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/518	116/9376	1.2483024896818	GNG10/GNG12/GNAI2/GRK3/GNG7/MAPK3/ADCY7/GRIA4	0.650709662259848
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/518	100/9376	1.26702702702703	CD14/CSF1R/CD4/CR1/IL2RA/ITGAM/EPOR	0.649168638276274
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/518	36/9376	1.50836550836551	CRYL1/DCXR/AKR1A1	0.738986609804528
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/518	36/9376	1.50836550836551	SSBP1/POLE/RNASEH2B	0.738986609804528
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/518	52/9376	1.39233739233739	IGF1/ALOX5/SCARB1/ADCY7	0.686029704537678
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/518	101/9376	1.25448220497725	CALM3/POMC/GNAI2/MITF/MAPK3/ADCY7/MAP2K2	0.621790134231162
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/518	21/9376	1.72384629527487	BCAT1/VNN1	0.803002296881394
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	13/518	203/9376	1.1591380261331	SPP1/FN1/JUN/FLT1/CCND1/IGF1/ITGB5/PDGFC/VEGFB/PAK2/RAC1/MAPK3/ROCK2	0.554305221078387
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/518	102/9376	1.24218335983042	ATP1B1/ATP2B4/KCNQ1/RAC1/ADCY7/CA2/ATP1A1	0.594693949713042
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/518	37/9376	1.46759887300428	COMT/MIF/IL4I1	0.689138971178917
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/518	119/9376	1.21683267901755	JUN/TNFRSF1A/MMP14/FOS/CASP7/MAPK3/BAG4/RHBDF2	0.575633107736492
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/518	70/9376	1.29288472145615	EPHX1/HPGDS/MGST2/CBR1/SULT1A1	0.59476703948426
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/518	154/9376	1.17534974677832	CALM3/ATP1B1/GNAI2/ATP2B4/KCNQ1/PPP2CB/SCN1B/MAPK3/ADCY7/ATP1A1	0.530561368377751
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	9/518	138/9376	1.18045996306866	CALM3/IGF1/PPP2CB/ANAPC11/CCNE1/YWHAE/MAPK3/ADCY7/ANAPC13	0.516433145853544
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/518	105/9376	1.20669240669241	CD14/PARP1/CCL4/TNFRSF1A/TLR4/LY96/SYK	0.515037156039069
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/518	105/9376	1.20669240669241	JUN/CALM3/FCER1G/EGR2/NFATC2/SYK/MAPK3	0.515037156039069
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	11/518	174/9376	1.14427728220832	MAN1A1/OS9/WFS1/P4HB/MAN1C1/CAPN1/BAX/UBXN6/CANX/XBP1/RPN2	0.464530402164574
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/518	226/9376	1.12126285577613	JUN/CALM3/ATP1B1/POMC/GNAI2/ATP2B4/FOS/RAC1/MAPK3/ADCY7/ROCK2/MAP2K2/GRIA4/ATP1A1	0.446225252969495
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/518	56/9376	1.29288472145615	MAN1A1/MAN1C1/MGAT1/RPN2	0.531576109617028
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	10/518	158/9376	1.14559405698646	IGF1/TNFRSF1A/LAMTOR1/ATP6V1F/LAMTOR2/EIF4B/MAPK3/MAP2K2/RRAGD/EIF4EBP1	0.446309899076971
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/518	73/9376	1.23975247262918	CCND1/RB1/BAX/MAPK3/MAP2K2	0.49727393338671
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/518	107/9376	1.18413740843647	CALM3/PYGL/PFKL/PGAM1/PKM/PDHB/LDHB	0.463233708395333
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/518	24/9376	1.50836550836551	HS2ST1/HS6ST1	0.602992803053384
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/518	41/9376	1.3244184951502	GABRB2/GABRA3/GRIA4	0.503411407674919
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/518	75/9376	1.20669240669241	MGST2/BAX/PMAIP1/MAPK3/TOP2A	0.434583278330156
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/518	75/9376	1.20669240669241	ATP1B1/GPX3/ADCY7/CANX/ATP1A1	0.434583278330156
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/518	144/9376	1.13127413127413	SLC25A6/SLC25A5/PSMA2/PSMA1/PSMD2/PSMB7/PSMB5/XBP1/PSMC1	0.383879730466764
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/518	93/9376	1.1677668451862	FGFR1/PTPN6/RAC1/MAPK3/IQGAP1/ROCK2	0.393175200525264
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/518	93/9376	1.1677668451862	FN1/CCND1/RB1/BIRC7/BAX/CCNE1	0.393175200525264
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/518	59/9376	1.22714482036516	NME4/CMPK2/NME2/NUDT2	0.423227107348529
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/518	59/9376	1.22714482036516	CCND1/BAX/MAPK3/MAP2K2	0.423227107348529
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/518	217/9376	1.0843549276729	EPHX1/JUN/CCND1/KLF4/MGST2/GNAI2/RB1/FOS/ARRB2/MAPK3/ADCY7/MAP2K2/EIF4EBP1	0.304017774066312
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/518	112/9376	1.13127413127413	TNFRSF1A/TLR4/GNAI2/LY96/BIRC7/ALOX5/MAPK3	0.337964879049762
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/518	43/9376	1.26281763491066	ACADVL/ECHS1/ACADS	0.417696443779649
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/518	148/9376	1.10069915475321	JUN/CCND1/IGF1/FGFR1/RB1/FOS/BAX/MAPK3/MAP2K2	0.298597089385299
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/518	10/9376	1.81003861003861	PAPSS1	0.619742561967665
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/518	149/9376	1.09331191210386	PDGFC/FCER1G/AGPAT2/LPAR6/CYTH4/SYK/MAPK3/ADCY7/MAP2K2	0.277640388142535
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/518	44/9376	1.23411723411723	PARP1/POLE/PARG	0.376404700280901
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/518	79/9376	1.14559405698646	EPHX1/HPGDS/MGST2/CBR1/AKR7A2	0.314245059202854
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/518	27/9376	1.34076934076934	ECHS1/ACADS	0.428787875244415
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/518	27/9376	1.34076934076934	HSD17B4/SCP2	0.428787875244415
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/518	133/9376	1.08874502859465	CCND1/IGF1/CAT/KLF2/TNFSF10/MAPK3/MAP2K2/CCNG2	0.249256250494623
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/518	169/9376	1.07102876333646	CTSB/CTSD/CTSL/VAMP8/STX7/PPP2CB/LAMP1/MAPK3/MAP2K2/RRAGD	0.225320763501912
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/518	28/9376	1.29288472145615	PPT1/ECHS1	0.375317712661671
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/518	154/9376	1.05781477210049	NME4/CMPK2/VKORC1/BCAT1/SPR/AKR1A1/NME2/SHMT1/AK1	0.174932015367328
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/518	65/9376	1.11386991386991	AGPAT2/AKR1A1/MGLL/MBOAT1	0.222766656841481
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/518	155/9376	1.05099016066758	CCND1/POMC/GNAI2/RB1/SCARB1/CCNE1/MAPK3/ADCY7/MAP2K2	0.154791068664002
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/518	12/9376	1.50836550836551	VKORC1	0.426107008510307
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/518	66/9376	1.0969930969931	JUN/TLR4/IL18/IL12RB2	0.191214417122802
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	9/518	158/9376	1.03103465128782	CCND1/RB1/PPP2CB/ANAPC11/ATRX/CCNE1/YWHAE/ANAPC13/ABL1	0.0951348727471891
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/518	122/9376	1.03854674346478	CSH1/IGF1/GNAI2/FOS/MAPK3/ADCY7/MAP2K2	0.103630010317786
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/518	31/9376	1.1677668451862	PGLS/PFKL	0.226245532338077
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/518	31/9376	1.1677668451862	HSD17B14/AKR1A1	0.226245532338077
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/518	13/9376	1.39233739233739	XRCC6	0.342299721496634
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/518	105/9376	1.03430777716492	JUN/RAB5C/FKBP8/MITF/FIS1/CITED2	0.0854882879531136
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/518	69/9376	1.04929774494992	JUN/CALM3/FOS/GRIA4	0.0993869634984965
Human Diseases	Immune disease	hsa05310	Asthma	2/518	32/9376	1.13127413127413	PRG2/FCER1G	0.179874834490714
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/518	51/9376	1.06472859414036	ATP6V1F/ATP6AP1/KCNQ1	0.112082942125156
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/518	14/9376	1.29288472145615	B3GNT2	0.265191192679911
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/518	33/9376	1.0969930969931	VAMP8/STX7	0.134970016881301
NA	NA	hsa04081	Hormone signaling	12/518	219/9376	0.991801978103348	CSH1/IGF1/POMC/GNG10/GNG12/SLC40A1/GNAI2/DIO2/GNG7/ADCY7/EPOR/APPL1	-0.0296850103301643
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/518	71/9376	1.01974006199358	CCND1/FOS/MAPK3/MAP2K2	0.0403740371183327
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/518	109/9376	0.99635152846162	JUN/CD4/IL2RA/NFATC2/FOS/MAPK3	-0.00926482691450328
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/518	34/9376	1.06472859414036	POLR2F/POLR2J	0.0914320341027038
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/518	72/9376	1.00557700557701	ISG15/IFIH1/ADAR/PIN1	0.0114872257557803
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/518	110/9376	0.987293787293787	IGF1/GNAI2/ANAPC11/MAPK3/ADCY7/ANAPC13	-0.0324152216838435
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/518	15/9376	1.20669240669241	AK1	0.193727694084474
Genetic Information Processing	Translation	hsa03010	Ribosome	12/518	222/9376	0.978399248669519	RPS4Y1/RPS9/RPS10/MRPL14/RPS12/RPL17/MRPL34/MRPS34/MRPL27/RPL23A/MRPS16/MRPS18B	-0.07876305821327
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/518	35/9376	1.03430777716492	HSD17B14/PFKL	0.0491714026269205
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	16/518	298/9376	0.971832810758985	CSF1R/CSH1/CCL3/CD4/CCL4/TNFRSF1A/CCR1/IL2RA/IL18/TNFSF10/GDF15/IL34/IL12RB2/TNFRSF21/TNFSF12/EPOR	-0.11949211124548
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/518	93/9376	0.973139037655167	CALM3/ATP1B1/ATP2B4/ADCY7/ATP1A1	-0.0629508425488357
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/518	36/9376	1.00557700557701	PYGL/GAA	0.0081070260991214
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/518	56/9376	0.969663541092113	CCND1/GRK3/ARRB2	-0.0550596723708786
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/518	37/9376	0.978399248669519	NAGK/GALE	-0.0318348063008338
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/518	17/9376	1.06472859414036	PAPSS1	0.0645934664256593
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/518	17/9376	1.06472859414036	CA2	0.0645934664256593
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/518	78/9376	0.928224928224928	BTG2/PFKL/NUDT16/LSM4	-0.153924887902214
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/518	59/9376	0.92035861527387	GNAI2/ADCY7/MGLL	-0.148391642075241
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/518	39/9376	0.928224928224928	SHMT1/GCSH	-0.108613782826841
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/518	138/9376	0.918135526831179	CALM3/PYGL/MKNK1/PRKAR1A/MAPK3/MAP2K2/EIF4EBP1	-0.234276493762399
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	13/518	254/9376	0.926397713799289	CALM3/FLT1/FGFR1/MCOLN1/PDGFC/PTAFR/ATP2B4/VEGFB/NFATC2/SLC25A6/SLC25A5/HTR2B/ADCY7	-0.287571477561673
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/518	178/9376	0.915188061255477	DKK2/JUN/CCND1/NFATC2/LZTS2/ROR1/SERPINF1/RAC1/ROCK2	-0.276250434414944
NA	NA	hsa04082	Neuroactive ligand signaling	10/518	199/9376	0.90956714072292	POMC/GNG10/GNG12/GNAI2/GNG7/HTR2B/GABRB2/ADCY7/GABRA3/GRIA4	-0.311806464481524
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/518	82/9376	0.882945663433468	NME4/MGST2/ITPA/NME2	-0.257439853764357
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/518	62/9376	0.87582513388965	IGF1/CAT/ADCY7	-0.23721607100916
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/518	142/9376	0.892272554244385	WWP1/BIRC7/ANAPC11/UBE2F/UBE2L3/ANAPC13/UBE2L6	-0.3127939035384
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/518	20/9376	0.905019305019305	NPL	-0.102822442088929
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/518	143/9376	0.886032886032886	C1QA/C2/FCGR2A/C1QB/C1QC/SNRPD3/CD28	-0.332092319603347
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/518	63/9376	0.861923147637433	POLE/POLR2F/POLR2J	-0.26590654768644
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/518	21/9376	0.861923147637433	CSGALNACT1	-0.153176206491726
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/518	65/9376	0.835402435402435	POMC/SCARB1/ADCY7	-0.322006471626366
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/518	86/9376	0.841878423273772	ATP1B1/TRPM4/ADCY7/ATP1A1	-0.356217445592903
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/518	44/9376	0.822744822744823	RAB5C/DCTN4	-0.284984068428568
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/518	67/9376	0.810465049271019	CALM3/MAPK3/MAP2K2	-0.376493838358894
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/518	23/9376	0.786973308712439	SSBP1	-0.247346148901514
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/518	23/9376	0.786973308712439	ATP6AP2	-0.247346148901514
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/518	47/9376	0.770229195761111	PKM/MAPK3	-0.381864166562568
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/518	69/9376	0.786973308712439	CTSB/CALM3/GNAI2	-0.429473518772732
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/518	70/9376	0.77573083287369	TNFRSF1A/POMC/APPL1	-0.4554280193113
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/518	48/9376	0.754182754182754	ATP1B1/ATP1A1	-0.412877654140973
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/518	194/9376	0.839708633523066	TUBA1B/CAPZB/TUBB2A/DYNLRB1/MYO7A/TUBB/DCTN4/MYO5A/TUBA1C	-0.545538031290266
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/518	134/9376	0.810465049271019	CALM3/MAPK3/ADCY7/ROCK2/MAP2K2/ADM	-0.534369182268328
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/518	49/9376	0.738791269403514	COLGALT1/GALNT1	-0.443299682615172
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/518	49/9376	0.738791269403514	JUN/GNAI2	-0.443299682615172
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/518	26/9376	0.696168696168696	PLB1	-0.375142325243975
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/518	26/9376	0.696168696168696	HHEX	-0.375142325243975
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/518	28/9376	0.646442360728075	B3GNT2	-0.453067144663147
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/518	99/9376	0.731328731328731	CALM3/IGF1/HTR2B/ADCY7	-0.649856886017176
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/518	29/9376	0.6241512448409	RASSF4	-0.490183483560347
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/518	29/9376	0.6241512448409	CALM3	-0.490183483560347
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/518	122/9376	0.74181910247484	CCND1/IGF1/PPP2CB/PFKL/EIF4EBP1	-0.694099855642443
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/518	30/9376	0.603346203346203	PLB1	-0.526189326879335
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/518	103/9376	0.702927615548975	ATP1B1/SLC7A8/KCNQ1/ATP1A1	-0.733083500004211
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/518	31/9376	0.5838834225931	TMEM208	-0.561162823713077
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/518	170/9376	0.745310015898251	CCND1/MGST2/HMOX1/RB1/BAX/MAPK3/MAP2K2	-0.810370311236334
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/518	32/9376	0.565637065637066	PPP2CB	-0.595174084711923
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/518	105/9376	0.689538518109947	IGF1/ITGB5/LMNA/ADCY7	-0.773609448218797
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/518	150/9376	0.724015444015444	CCND1/RB1/BAX/CCNE1/MAPK3/MAP2K2	-0.823960446445279
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/518	109/9376	0.664234352307747	TNFRSF1A/PYGL/TBC1D4/SLC27A4	-0.852633925461906
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/518	86/9376	0.631408817455329	ITGB5/DSC2/LMNA	-0.83036491434348
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/518	62/9376	0.5838834225931	DTX3L/NCSTN	-0.794923664234305
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/518	110/9376	0.658195858195858	NBL1/PPP2CB/MAPK3/RGMA	-0.871987372257648
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/518	63/9376	0.574615431758289	COLGALT1/ECHS1	-0.81919988792347
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/518	36/9376	0.502788502788503	GALNT1	-0.722772557606285
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/518	89/9376	0.610125374170318	SPP1/FN1/ITGB5	-0.893644797951581
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/518	37/9376	0.489199624334759	IL4I1	-0.752808583780585
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/518	38/9376	0.476325950010161	NNMT	-0.782183404123158
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/518	38/9376	0.476325950010161	CD4	-0.782183404123158
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/518	94/9376	0.577671896820833	JUN/FOS/MAPK3	-0.995120806314471
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/518	41/9376	0.441472831716734	SSBP1	-0.866685938728576
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/518	144/9376	0.628485628485629	IGF1/FGFR1/KLF4/MAPK3/MAP2K2	-1.0864047273994
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/518	168/9376	0.646442360728075	CSH1/CCND1/IL2RA/PTPN6/IL12RB2/EPOR	-1.11818816432228
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/518	99/9376	0.548496548496548	IGF1/ITGB5/LMNA	-1.09208784575713
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/518	73/9376	0.495900989051674	HPGDS/MGST2	-1.04555876000634
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/518	44/9376	0.411372411372411	GTF2I	-0.946372837138036
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/518	157/9376	0.576445417209749	ITGB2/CCND1/PPP2CB/YWHAE/DLG2	-1.29419579350637
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/518	50/9376	0.362007722007722	CD28	-1.09379365295505
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/518	54/9376	0.335192335192335	CENPX	-1.18473448135097
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/518	86/9376	0.420939211636886	SCN9A/GABRA3	-1.30451238309406
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/518	191/9376	0.568598516242495	CALM3/GNG10/GNG12/GNAI2/GNG7/MAPK3	-1.45660373046269
NA	NA	hsa04382	Cornified envelope formation	7/518	217/9376	0.5838834225931	KRT7/S100A13/KRT19/PPP2CB/CAPN1/PRSS8/SLC27A4	-1.49969704325856
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/518	63/9376	0.287307715879144	BAX	-1.3724932281605
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/518	98/9376	0.369395634701757	CALM3/CDS1	-1.51748884276231
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	7/518	233/9376	0.54378842361675	FN1/ITGB5/CAPZB/ATP1B1/DSC2/LMNA/ATP1A1	-1.70522849808804
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/518	66/9376	0.274248274248274	COMT	-1.43076360604673
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/518	68/9376	0.26618214853509	ALDH1A1	-1.4685786888856
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/518	108/9376	0.335192335192335	SUMO3/NUP214	-1.68034153782919
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/518	78/9376	0.232056232056232	PLCH1	-1.64689014545858
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/518	83/9376	0.218076940968507	L3MBTL2	-1.73024569933838
Genetic Information Processing	Transcription	hsa03040	Spliceosome	6/518	243/9376	0.44692311358978	PRPF8/SNRPC/SNRPD3/LSM4/RBM17/SNRNP27	-2.11234376603446
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/518	103/9376	0.175731903887244	PPP2CB	-2.03404076739339
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/518	370/9376	0.440279661901284	CSH1/POMC/PTAFR/LPAR6/HTR2B/GABRB2/GABRA3/GRIA4/ADM	-2.65637056131767
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/518	323/9376	0.392268429420132	FSCN1/CCND1/HMOX1/CCNE1/MAPK3/MAP2K2/ABL1	-2.68781565322712
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/518	183/9376	0.197818427326624	RRP7A/RPP25	-2.6500390663232
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/518	449/9376	0.161250655682727	CALM3/GRK3/ARRB2/GNG7	-4.40438502020784