category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	23/315	142/9376	4.821104404203	PLCG2/FOSB/SQSTM1/NCF1/NFKBIA/LILRB3/FCGR3A/JUN/NFKB2/LILRB2/LILRB4/GRB2/LILRB1/SPI1/JAK1/TNF/IFNGR2/ACP5/FCGR2B/SIRPA/SOCS3/LILRA1/FOSL1	8.55442831006194
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/315	155/9376	4.60878648233487	HLA-DRB1/ITGB2/NCF1/HLA-E/OLR1/HLA-F/HLA-C/ITGA5/HLA-A/FCGR3A/ITGAM/CD14/CANX/DYNC1H1/HLA-G/TLR4/CTSL/HLA-B/C3/COLEC12/TCIRG1/FCAR/FCGR2B/HLA-DRB3	8.44677401637837
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/315	82/9376	5.80782036391792	CTSB/HLA-DRB1/IFI30/HLA-E/HLA-F/HLA-C/HLA-A/TAPBP/LGMN/CANX/HLA-G/CTSL/TNF/HLA-B/HSPA6/HLA-DRB3	8.152797860864
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/315	88/9376	5.41183261183261	ITGB2/THBD/C3AR1/ITGAM/PLAUR/SERPINE2/SERPINE1/C1QB/C1QC/VSIG4/C1QA/CFD/C3/PLAU/CLU/C5AR1	7.7526844780172
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	24/315	205/9376	3.48469221835076	HLA-E/HLA-F/HLA-C/NFKBIA/HLA-A/YWHAE/ACTN4/JUN/NFKB2/CDC42/REL/CHD4/GRB2/HLA-G/CDKN1A/PRKACA/JAK1/HLA-B/C3/ATF6B/PKM/STAT3/IRF7/HDAC7	6.70647073111515
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/315	95/9376	5.01306599832916	HLA-DRB1/VEGFA/CCL3/ITGB2/FLT1/JUN/CCL20/CCL2/TLR4/CTSL/TNF/CCL5/ACP5/TCIRG1/CXCL1/HLA-DRB3	7.32982436509361
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/315	103/9376	4.62370164894437	CCL3/CFLAR/GNAS/NFKBIA/JUN/SERPINE1/C1QB/C1QC/CCL2/TLR4/C1QA/TNF/IFNGR2/C3/CCL5/PPP2CA	6.89467447082307
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	24/315	224/9376	3.1891156462585	HLA-DRB1/ITGB2/HLA-E/HLA-F/HLA-C/NFKBIA/TLN1/GPS2/HLA-A/JUN/NFKB2/IL1R2/CANX/HLA-G/CDKN1A/SPI1/PRKACA/JAK1/TNF/HLA-B/ATF6B/ETS2/FOSL1/HLA-DRB3	6.18283359941947
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	24/315	227/9376	3.14696874344451	VEGFA/CCL4/CCL3/HLA-E/HLA-F/GNAS/HLA-C/NFKBIA/HLA-A/TAPBP/ROCK1/GRB2/HLA-G/CCL2/CDKN1A/AKAP13/PRKACA/JAK1/TNF/HLA-B/ATF6B/CCL5/CRK/STAT3	6.10526735054008
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	21/315	180/9376	3.47259259259259	HLA-DRB1/HLA-E/HLA-F/HLA-C/NFKBIA/ITGA5/HLA-A/TAPBP/HLA-G/CCL2/TNFRSF14/JAK1/TNF/HLA-B/IFNGR2/C3/CCL5/TNFSF14/SOCS3/IRF7/HLA-DRB3	6.24514009213677
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	15/315	99/9376	4.50986050986051	HLA-DRB1/ITGB2/C3AR1/FCGR3A/ITGAM/C1QB/C1QC/KRT19/C1QA/CFD/C3/FCAR/FCGR2B/C5AR1/HLA-DRB3	6.54570646293138
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	22/315	204/9376	3.2099595393713	PLCG2/FN1/VEGFA/FLNA/ITGA5/TIMP3/PLAUR/CDC42/EZR/ROCK1/GRB2/CDKN1A/MMP9/PRKACA/TLR4/HSPG2/CTSL/TNF/FGFR1/CD44/STAT3/PLAU	5.95004476488658
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/315	205/9376	3.19430120015486	PLCG2/HLA-DRB1/HLA-E/HLA-F/HLA-C/NFKBIA/HLA-A/JUN/TAPBP/NFKB2/NFKBIE/VIM/HLA-G/CDKN1A/JAK1/TNF/HLA-B/CD44/CXCL10/STAT3/IRF7/HLA-DRB3	5.92267189690695
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/315	78/9376	4.96084656084656	HLA-DRB1/ITGB2/NCF1/NFKBIA/FCGR3A/JUN/ITGAM/TLR4/JAK1/TNF/IFNGR2/C3/HLA-DRB3	6.54927759910198
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/315	56/9376	5.84671201814059	ITGB2/NFKBIA/ITGAM/NFKB2/CD14/CLK1/TLR4/TNF/C3/HSPA6/CXCL1	6.78244253443953
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/315	119/9376	4.00202747765773	CFLAR/NFKBIA/JUN/CCL20/CEBPB/MAP3K8/CCL2/MMP9/TNF/TNFRSF1B/ATF6B/CXCL10/CCL5/MMP14/SOCS3/CXCL1	6.144773253756
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/315	39/9376	6.86886446886447	HLA-DRB1/HLA-E/HLA-F/HLA-C/HLA-A/HLA-G/TNF/HLA-B/HLA-DRB3	6.84755539639577
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/315	103/9376	4.04573894282632	FN1/ITGB2/GNAS/ACTN4/COL4A1/ITGAM/IL1R2/CD14/PRKACA/TLR4/TNF/HSPB1/CXCL1/LAMA3	5.79500758292661
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/315	78/9376	4.57924297924298	ITGB2/ITGA5/JUN/ITGAM/CD14/C1QB/C1QC/TLR4/C1QA/TNF/C3/NLRP3	5.9182943609633
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/315	44/9376	6.08831168831169	HLA-DRB1/HLA-E/HLA-F/HLA-C/HLA-A/HLA-G/TNF/HLA-B/HLA-DRB3	6.30762011633738
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/315	45/9376	5.95301587301587	HLA-DRB1/HLA-E/HLA-F/HLA-C/HLA-A/HLA-G/TNF/HLA-B/HLA-DRB3	6.20961582012689
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/315	144/9376	3.30723104056437	NFKBIA/C3AR1/ALDH2/CD14/C1QB/TRA2B/C1QC/SCD/TLR4/ACADVL/C1QA/TNF/C3/SREBF1/C5AR1/CXCL1	5.20208308132713
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/315	181/9376	2.96006314127861	HLA-DRB1/PLK3/ITGB2/CTSD/FCGR3A/ITGAM/CEBPB/CD14/LSP1/TLR4/JAK1/SPHK1/TNF/IFNGR2/C3/TCIRG1/FCGR2B/HLA-DRB3	4.96462365733027
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	20/315	216/9376	2.75602586713698	CCL3/NCF1/OLR1/NFKBIA/JUN/CD14/CDC42/LDLR/NFE2L2/CCL2/MMP9/TLR4/ABCG1/TNF/CCL5/STAT3/NLRP3/IRF7/HSPA6/CXCL1	4.8681381870736
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/315	91/9376	3.9250654107797	PLCG2/NFKBIA/LILRB3/JUN/LILRB2/NFKBIE/LILRB4/GRB2/LILRB1/FCGR2B/LILRA1/INPP5D	5.2277904890536
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	19/315	203/9376	2.78589412776605	FN1/SPP1/VEGFA/FLNA/ITGA5/TLN1/FLT1/ACTN4/JUN/COL4A1/PDGFB/CDC42/EMP1/ROCK1/GRB2/VASP/CRK/ZYX/LAMA3	4.7962397199158
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/315	54/9376	4.96084656084656	HLA-DRB1/HLA-E/HLA-F/HLA-C/HLA-A/CGA/HLA-G/HLA-B/HLA-DRB3	5.44230903593614
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/315	109/9376	3.54996359400029	SPP1/CCL4/CCL3/NFKBIA/JUN/CD14/MAP3K8/TLR4/JAK1/TNF/CXCL10/CCL5/IRF7	4.99264282219216
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/315	157/9376	3.0333838843393	STAB1/LRP1/ALOX5/CEBPB/DUSP2/C1QB/C1QC/SPHK1/C1QA/BSG/CRK/SIRPA/DUSP8/HAVCR2/MERTK/SGK1	4.79049229324025
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/315	100/9376	3.57180952380952	HLA-DRB1/ITGA5/ANPEP/ITGAM/IL1R2/CD14/CSF3R/FLT3/CD9/TNF/CD44/HLA-DRB3	4.82071303909468
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	25/315	333/9376	2.2346155679489	FN1/SPP1/VEGFA/HLA-E/HLA-F/GNAS/HLA-C/ITGA5/HLA-A/COL4A1/CDC42/LFNG/CHD4/GRB2/HLA-G/CDKN1A/PRKACA/JAK1/TNF/HLA-B/PKM/TCIRG1/PPP2CA/NOTCH1/LAMA3	4.27711029971445
NA	NA	hsa04518	Integrin signaling	15/315	154/9376	2.89919604205319	FN1/SPP1/VEGFA/ITGB2/FLNA/ITGA5/TLN1/FLT1/ACTN4/COL4A1/ITGAM/PDGFB/CDC42/C3/LAMA3	4.43068064359915
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/315	94/9376	3.48314758527525	FOSB/NFKBIA/JUN/CCL20/CEBPB/CCL2/MMP9/TNF/CXCL10/FOSL1/CXCL1	4.51126695344825
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	17/315	196/9376	2.58166504697117	PLCG2/VEGFA/HLA-E/HLA-F/HLA-C/NFKBIA/HLA-A/JUN/PDGFB/HLA-G/CDKN1A/JAK1/HLA-B/C3/STAT3/IRF7/CXCL1	4.17228592004556
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/315	112/9376	3.1891156462585	HLA-DRB1/NFKBIA/ALOX5/LDLR/TLR4/JAK1/TNF/IFNGR2/STAT3/HSPA6/LAMA3/HLA-DRB3	4.34541533895358
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	19/315	238/9376	2.37620381485928	PLCG2/NFKBIA/C3AR1/JUN/C1QB/C1QC/RPS9/CCL2/TLR4/JAK1/C1QA/TNF/CFD/RPS17/C3/CXCL10/STAT3/NLRP3/C5AR1	4.00957654624178
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	17/315	201/9376	2.51744452341467	ID2/FLT1/ITGAM/IL1R2/CEBPB/CD14/REL/NUPR1/FUS/FLT3/CDKN1A/SPI1/MMP9/MAF/IGFBP3/PLAU/HPGD	4.05471809048075
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	22/315	300/9376	2.18277248677249	VEGFA/FLNA/NR4A1/FLT1/JUN/PDGFB/NFKB2/CD14/AREG/MAP3K8/CDC42/DUSP2/GRB2/FLT3/PRKACA/TNF/HSPB1/FGFR1/CRK/DUSP8/HSPA6/DUSP9	3.8821065156976
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	25/315	362/9376	2.0555994036657	FN1/SPP1/VEGFA/ITGA5/CDC37/YWHAE/NR4A1/FLT1/COL4A1/PDGFB/MCL1/AREG/DDIT4/CSF3R/GRB2/FLT3/CDKN1A/TLR4/JAK1/FGFR1/ATF6B/EIF4E/PPP2CA/LAMA3/SGK1	3.81898097183285
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/315	100/9376	3.27415873015873	CCL4/CCL3/CCL20/CCL2/TNFRSF14/TNF/TNFRSF1B/CXCL10/CCL5/TNFSF14/CXCL1	4.26278328233579
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/315	70/9376	3.8269387755102	HLA-DRB1/ITGB2/HLA-E/HLA-F/HLA-C/HLA-A/HLA-G/HLA-B/HLA-DRB3	4.42625824400052
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/315	101/9376	3.24174131698884	PLCG2/FN1/VEGFA/THBD/JUN/COL4A1/CDC42/SERPINE1/CCL2/TNF/STAT3	4.22320413198477
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/315	105/9376	3.11824640967498	PLCG2/CCL4/CFLAR/NFKBIA/NFKB2/CD14/TLR4/TNF/TNFSF14/PLAU/CXCL1	4.06968399177953
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	16/315	193/9376	2.46757134632782	PLCG2/CCL4/CCL3/NCF1/NFKBIA/CCL20/CDC42/ROCK1/GRB2/CCL2/PRKACA/CXCL10/CCL5/CRK/STAT3/CXCL1	3.84094807441435
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/315	110/9376	2.97650793650794	PLCG2/VEGFA/LDHA/TIMP1/FLT1/SERPINE1/CDKN1A/TLR4/IFNGR2/STAT3/EIF4E	3.88777933587307
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/315	50/9376	4.16711111111111	HBA2/ITGB2/HBA1/LRP1/CCL2/TLR4/TNF	4.18652266182027
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/315	66/9376	3.60788840788841	HLA-DRB1/JUN/TLR4/TNF/IFNGR2/MAF/STAT3/HLA-DRB3	3.96404869761742
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/315	98/9376	3.03725299643667	PLCG2/NCF1/FCGR3A/CDC42/SPHK1/VASP/CRK/FCGR2B/INPP5D/ASAP3	3.77992923078572
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/315	116/9376	2.82255062944718	PLCG2/ITGB2/NCF1/ACTN4/ITGAM/CDC42/EZR/CD99/ROCK1/MMP9/VASP	3.68261190489256
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	14/315	173/9376	2.408734746307	HLA-DRB1/NFKBIA/CCL2/TLR4/JAK1/TNF/PABPN1/IFNGR2/CXCL10/CCL5/NLRP3/SOCS3/IRF7/HLA-DRB3	3.48690742259644
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	17/315	233/9376	2.17170106955515	FN1/LMNA/PLEC/ATP1B3/ITGA5/TLN1/COL4A1/VIM/FBLN1/FMNL1/DSC2/HSPG2/TPM3/MYH9/ZYX/TPM4/TPM1	3.37678396513614
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/315	156/9376	2.48042328042328	CFLAR/NFKBIA/YWHAE/LDLR/GRB2/CDKN1A/JAK1/TNF/CXCL10/STAT3/SOCS3/IRF7/PPP2CA	3.47644685405683
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	19/315	275/9376	2.05649639249639	MT-ND5/NCF1/MT-CO3/MT-ND4L/MT-CO1/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/C1QB/C1QC/PRKACA/C1QA/TNF/ATF6B/CCL5/MT-ND4/NOTCH1/HSPA6	3.31545133852228
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/315	160/9376	2.4184126984127	HLA-DRB1/ITGB2/HLA-E/HLA-F/HLA-C/HLA-A/ITGAM/SIGLEC1/CD99/HLA-G/HLA-B/PTPRF/HLA-DRB3	3.37399332325133
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/315	142/9376	2.51535881958417	VEGFA/SQSTM1/NCF1/THBD/JUN/PDGFB/IL1R2/NFE2L2/CCL2/MMP9/CTSL/TNF	3.39248212425033
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/315	109/9376	2.73074122615407	HLA-DRB1/NFKBIA/JUN/NFKBIE/IL27RA/JAK1/IFNGR2/STAT3/EBI3/HLA-DRB3	3.38866514806767
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/315	93/9376	2.88049155145929	HLA-DRB1/NFKBIA/JUN/NFKBIE/JAK1/IFNGR2/MAF/NOTCH1/HLA-DRB3	3.39798561139116
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/315	20/9376	5.95301587301587	SQLE/SC5D/CYP51A1/MSMO1	4.13420931267482
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	14/315	187/9376	2.22840166369578	CTSB/GABARAPL1/NFKBIA/YWHAE/JUN/CCL2/TLR4/JAK1/TNF/CCL5/P2RX7/NLRP3/IRF7/CXCL1	3.16358802794283
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	17/315	253/9376	2.00002509567727	PLCG2/SQSTM1/NFKBIA/ITGA5/TLN1/ACTN4/JUN/CD14/CDC42/ROCK1/TLR4/TNF/CD44/C3/CCL5/CRK/NLRP3	3.00645821227648
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/315	133/9376	2.46177348132235	PLCG2/ITGB2/HLA-E/HLA-C/HLA-A/FCGR3A/GRB2/HLA-G/TNF/HLA-B/IFNGR2	3.1655725603753
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/315	214/9376	2.08633733867379	PLCG2/HLA-E/HLA-F/HLA-C/NFKBIA/HLA-A/JUN/TAPBP/SAMHD1/HLA-G/TLR4/TNF/HLA-B/TNFRSF1B/CRK	2.99729369306208
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/315	138/9376	2.37257878997009	FN1/NFKBIA/ITGA5/JUN/CDC42/ROCK1/CCL2/TLR4/TNF/CRK/NLRP3	3.02859149021887
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/315	52/9376	3.43443223443223	APOE/APOC2/APOC1/LRP1/LDLR/PLTP	3.2820944835813
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/315	163/9376	2.19129418638621	NFKBIA/JUN/GRB2/CDKN1A/MMP9/TLR4/HSPG2/JAK1/TNF/ATF6B/STAT3/IRF7	2.860652725017
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/315	70/9376	2.97650793650794	VEGFA/JUN/PDGFB/CDC42/GRB2/CDKN1A/CRK	3.0947025185297
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/315	71/9376	2.93458528951487	PLCG2/NFKBIA/JUN/CDC42/CCL5/TCIRG1/CXCL1	3.05078580235199
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/315	227/9376	1.96685546465282	VEGFA/MT-ND5/NCF1/MT-CO3/MT-ND4L/MT-CO1/NFKBIA/JUN/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/GRB2/NFE2L2/MT-ND4	2.74941641281919
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	16/315	250/9376	1.90496507936508	CTSB/CTSD/CLN8/PSAP/CTSZ/SLC2A6/IDS/LGMN/BORCS5/CTSL/AP2A2/HEXB/ACP5/TCIRG1/AP5B1/MAN2B1	2.70404828944801
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	16/315	250/9376	1.90496507936508	HLA-E/HLA-F/HLA-C/ACAP1/HLA-A/CDC42/DAB2/LDLR/HLA-G/CHMP1B/VPS37B/HLA-B/AP2A2/CHMP4A/HSPA6/ASAP3	2.70404828944801
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	18/315	298/9376	1.79789069990412	CCL4/CCL3/CCL20/IL1R2/TNFRSF12A/CSF3R/IL27RA/CCL2/TNFRSF14/TNF/TNFRSF1B/IFNGR2/CXCL10/CCL5/TNFSF14/CXCL1/EBI3/IL13RA1	2.60981243303238
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/315	323/9376	1.75088702147526	PLCG2/VEGFA/ITGA5/TIMP3/PDGFB/MCL1/DDIT4/VIM/EZR/ROCK1/GRB2/CDKN1A/MMP9/CD44/CRK/STAT3/PLAU/NOTCH1/TPM1	2.56054521291354
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/315	115/9376	2.32944099378882	GNAS/NR4A2/CDKN1A/AKAP13/PRKACA/FGFR1/ATF6B/MMP14/SGK1	2.67449563999903
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/315	137/9376	2.17263353029776	CTSB/LMNA/CTSD/CFLAR/NFKBIA/JUN/MCL1/CTSZ/CTSL/TNF	2.57788154942702
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/315	80/9376	2.60444444444444	PLCG2/VEGFA/PDGFB/GRB2/JAK1/STAT3/EIF4E	2.68704209220428
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	10/315	138/9376	2.15688980906372	MT-ND5/MT-CO3/MT-ND4L/MT-CO1/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/TCIRG1/MT-ND4	2.55267432110594
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/315	248/9376	1.80030721966206	AHNAK/FLNA/NFKBIA/S100A10/JUN/CD14/CDC42/ANXA2/DYNC1H1/TLR4/TNF/DYNLRB1/CYFIP1/FHOD1/NLRP3	2.38148367801379
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	13/315	205/9376	1.88754161827333	MT-ND5/NCF1/CTSD/MT-CO3/MT-ND4L/MT-CO1/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/MMP9/PDK4/MT-ND4	2.39557714297006
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/315	83/9376	2.51030789825971	CCL4/NFKBIA/SAMHD1/CXCL10/CCL5/NLRP3/IRF7	2.57679234170748
Human Diseases	Immune disease	hsa05310	Asthma	4/315	32/9376	3.72063492063492	HLA-DRB1/PRG2/TNF/HLA-DRB3	2.87429733557198
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/315	122/9376	2.19578454332553	PLCG2/GNAS/GRB2/PRKACA/ATF6B/CRK/STAT3/IGFBP3/SOCS3	2.47868279972081
NA	NA	hsa03272	Virion - Hepatitis viruses	5/315	48/9376	3.1005291005291	LDLR/CHMP1B/CD9/HSPG2/CHMP4A	2.72024425934949
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/315	49/9376	3.03725299643667	FOSB/GNAS/JUN/PRKACA/ATF6B	2.66578344614393
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/315	105/9376	2.26781557067271	PLCG2/PLK3/NFKBIA/JUN/NFKB2/LSP1/TNF/NLRP3	2.43579250691955
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/315	105/9376	2.26781557067271	LMNA/GNAS/ITGA5/PRKACA/TNF/TPM3/TPM4/TPM1	2.43579250691955
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/315	106/9376	2.24642108415693	NFKBIA/PDGFB/IL1R2/GRB2/CDKN1A/MMP9/FGFR1/PLAU	2.4061943476381
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/315	168/9376	1.94890400604686	SQSTM1/CFLAR/CHMP1B/TLR4/JAK1/TNF/IFNGR2/CHMP4A/STAT3/NLRP3/HMGB1	2.31391347703606
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/315	168/9376	1.94890400604686	PDGFB/MCL1/CSF3R/IL27RA/GRB2/CDKN1A/JAK1/IFNGR2/STAT3/SOCS3/IL13RA1	2.31391347703606
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/315	68/9376	2.62633053221289	ITGAM/CD14/GRB2/FLT3/SPI1/STAT3	2.50950424305638
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	13/315	212/9376	1.82521713087751	VEGFA/ITGB2/GNAS/TLN1/RALGDS/FLT1/ITGAM/PDGFB/CDC42/VASP/FGFR1/CRK/P2RY1	2.26592992578455
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/315	87/9376	2.39489144316731	ATP1B3/MT-CO3/MT-CO1/MT-CYB/TPM3/TPM4/TPM1	2.4370722518794
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/315	169/9376	1.93737202967972	CTSB/SQSTM1/CTSD/CFLAR/GABARAPL1/VMP1/DDIT4/PRKACA/CTSL/PPP2CA/HMGB1	2.29270997799538
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/315	69/9376	2.58826777087647	PLCG2/ALOX5/GRB2/TNF/INPP5D/ALOX5AP	2.46885885286633
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/315	52/9376	2.86202686202686	GNAS/ALOX5/LDLR/CGA/PRKACA	2.5103792193106
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/315	70/9376	2.5512925170068	NFKBIA/NFKBIE/TNF/TNFRSF1B/STAT3/SOCS3	2.4289246557943
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/315	89/9376	2.34107365792759	FN1/SPP1/ITGA5/COL4A1/HSPG2/CD44/LAMA3	2.3700786733494
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/315	130/9376	2.06065934065934	VEGFA/GNAS/NFKBIA/JUN/COL4A1/GRB2/MMP9/PRKACA/ATF6B	2.27051043605689
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/315	90/9376	2.31506172839506	NFKBIA/JUN/NFKBIE/TLR4/JAK1/IFNGR2/STAT3	2.33725395762272
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/315	110/9376	2.16473304473304	SKIL/SMAD7/ID2/EMP3/ROCK1/TNF/HAMP/PPP2CA	2.29102295997964
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/315	93/9376	2.24038231780167	GNAS/JUN/CDC42/CGA/GRB2/PRKACA/MMP14	2.24132954239722
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/315	157/9376	1.89586492771206	SQSTM1/HLA-E/HLA-F/HLA-C/HLA-A/SERPINE1/HLA-G/CDKN1A/HLA-B/IGFBP3	2.110587216237
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/315	75/9376	2.38120634920635	ATP1B3/GNAS/CGA/CANX/PRKACA/ATF6B	2.23911925937205
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/315	77/9376	2.31935683364255	VEGFA/RALGDS/CDC42/CDKN1A/JAK1/STAT3	2.16741642140375
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/315	139/9376	1.92723535457348	CTSD/GNAS/JUN/GRB2/MMP9/PRKACA/KRT19/ATF6B/HSPA6	2.05345296997542
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/315	98/9376	2.12607709750567	ATP1B3/GNAS/NR4A1/NR4A2/LDLR/PRKACA/ATF6B	2.08932898585742
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/315	41/9376	2.90391018195896	VEGFA/CDKN1A/MMP9/TYMP	2.27789695238999
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/315	99/9376	2.10460157126824	GNAS/JUN/GRB2/CDKN1A/MMP9/PRKACA/NOTCH1	2.06002421569227
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	8/315	120/9376	1.98433862433862	PLCG2/NFKBIA/YWHAE/JUN/NFKBIE/CDC42/GRB2/CRK	2.02337475254049
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	13/315	232/9376	1.66787082649152	FN1/ITGB2/ITGA5/ACTN4/ITGAM/PDGFB/CDC42/EZR/ROCK1/FGFR1/CYFIP1/CRK/MYH9	1.92053049269821
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/315	60/9376	2.48042328042328	PLCG2/VEGFA/CDC42/SPHK1/HSPB1	2.14486341315512
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/315	143/9376	1.87332667332667	HLA-DRB1/FCGR3A/ACTN4/C1QB/C1QC/C1QA/TNF/C3/HLA-DRB3	1.96212276016788
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/315	122/9376	1.95180848295602	NFKBIA/JUN/NFKBIE/MAP3K8/CDC42/GRB2/TNF/PPP2CA	1.97295685790546
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	13/315	235/9376	1.64657885849375	MT-ND5/MT-CO3/MT-ND4L/GNAS/MT-CO1/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/GRB2/PRKACA/FGFR1/MT-ND4	1.8715930625706
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/315	238/9376	1.62582366279845	PLCG2/VEGFA/RALGDS/FLT1/PDGFB/CDC42/RASA3/REL/GRB2/FLT3/PRKACA/FGFR1/ETS2	1.82334030275623
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	10/315	170/9376	1.75088702147526	ACTN4/JUN/CDC42/EZR/ROCK1/PRKACA/VASP/MYH9/PPP2CA/RAB13	1.84211366087455
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/315	65/9376	2.28962148962149	GNAS/NR4A1/LDLR/PRKACA/ATF6B	1.94524194790621
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/315	86/9376	2.0766334440753	PLCG2/JUN/AREG/GRB2/CDKN1A/CRK	1.87008817869717
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	11/315	200/9376	1.63707936507936	NFKBIA/JUN/CDC42/EZR/ROCK1/MYO1G/TLR4/TNF/CYFIP1/MYH9/NLRP3	1.69798826260159
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/315	69/9376	2.15688980906372	FOSB/GNAS/JUN/PRKACA/ATF6B	1.7983098941318
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/315	136/9376	1.75088702147526	NFKBIA/JUN/TLR4/JAK1/STAT3/FCGR2B/IRF7/HSPA6	1.64460238752021
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/315	51/9376	2.33451602863368	PLCG2/GNAS/PRKACA/TCIRG1	1.78171120848801
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/315	93/9376	1.92032770097286	ACTN4/CDC42/ROCK1/SNAI1/FGFR1/PTPRF	1.66300150790025
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	8/315	138/9376	1.72551184725098	FLOT1/GRB2/PRKACA/PTPRF/CRK/SREBF1/EIF4E/SOCS3	1.60083998288008
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/315	53/9376	2.24642108415693	ATP1B3/GNAS/PRKACA/AP2A2	1.6965932288699
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/315	34/9376	2.62633053221289	BHLHE40/BHLHE41/CSNK1E	1.77125542054037
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/315	17/9376	3.50177404295051	NRP2/MYH9	1.9249110657569
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/315	99/9376	1.8039442039442	LMNA/ITGA5/TNF/TPM3/TPM4/TPM1	1.49931393478738
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	13/315	268/9376	1.4438284766643	MT-ND5/MT-CO3/MT-ND4L/GNAS/MT-CO1/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/NFE2L2/PRKACA/SLC39A1/MT-ND4	1.37443403074312
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/315	18/9376	3.30723104056437	HEXB/MAN2B1	1.82679017810239
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/315	195/9376	1.52641432641433	PLCG2/ITGB2/NCF1/FCGR3A/ITGAM/TLR4/C3/C5AR1/HMGB1/HDAC7	1.38500984985466
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/315	37/9376	2.41338481338481	HBA2/HBA1/TNF	1.6060680580061
Organismal Systems	Immune system	hsa04611	Platelet activation	7/315	126/9376	1.65361552028219	PLCG2/GNAS/TLN1/ROCK1/PRKACA/VASP/P2RY1	1.37717652800871
NA	NA	hsa04517	IgSF CAM signaling	14/315	299/9376	1.39368264585656	PLCG2/ITGB2/ITGA5/ACTN4/ITGAM/CDC42/EZR/GRB2/NRP2/FGFR1/PTPRF/MYH9/CD84/INPP5D	1.28992228908114
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/315	174/9376	1.53957307060755	RRBP1/PPP1R15A/CANX/NFE2L2/ATF6B/HSPH1/HYOU1/SELENOS/HSPA6	1.33948121077962
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/315	19/9376	3.13316624895572	IDS/HEXB	1.73534584095023
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/315	103/9376	1.73388811835414	DDX39B/FUS/PABPN1/PNN/CPSF1/PPP2CA	1.39634003134079
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/315	154/9376	1.54623788909503	ATP1B3/GNAS/PRKACA/TPM3/ATF6B/PPP2CA/TPM4/TPM1	1.27433165846185
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/315	21/9376	2.83476946334089	CHSY1/DSE	1.56935828601974
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/315	157/9376	1.51669194216965	ITGB2/SMAD7/ID2/YWHAE/AREG/SERPINE1/PPP2CA/CSNK1E	1.21728552390259
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/315	157/9376	1.51669194216965	MT-CO3/MT-CO1/JUN/CDC42/MT-CYB/TNF/SREBF1/SOCS3	1.21728552390259
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/315	109/9376	1.63844473569244	NFKBIA/TNF/PTPRF/SREBF1/STAT3/SOCS3	1.25002824923503
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/315	133/9376	1.56658312447786	PLK3/GABARAPL1/GRB2/CDKN1A/STAT3/CSNK1E/SGK1	1.22697532479268
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/315	63/9376	1.88984630889393	LTA4H/ALOX5/ALOX15B/HPGD	1.32127533078495
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/315	22/9376	2.70591630591631	AOC1/ALDH2	1.49356190504135
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/315	87/9376	1.7106367451195	RALGDS/JUN/AREG/GRB2/CDKN1A	1.24158270608082
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/315	44/9376	2.02943722943723	GNAS/DYNC1H1/PRKACA	1.27612052379192
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/315	243/9376	1.34739042393363	HNRNPU/CWC25/DDX39B/FUS/TRA2B/HNRNPA3/RBM25/DHX16/PRPF8/PRPF38B/HSPA6	1.02297989984653
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/315	93/9376	1.60027308414405	FN1/NFKBIA/COL4A1/CDKN1A/LAMA3	1.08467347340328
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/315	47/9376	1.89989868287741	LDHA/ALDH2/PKM	1.15312887828117
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/315	47/9376	1.89989868287741	TNF/PKM/SOCS3	1.15312887828117
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/315	144/9376	1.44691358024691	SKIL/ID2/GRB2/JAK1/FGFR1/STAT3/DUSP9	1.00765009387578
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/315	71/9376	1.67690587972278	CGA/GRB2/STAT3/SOCS3	1.06746125827552
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/315	71/9376	1.67690587972278	LDHA/FLT3/FGFR1/PKM	1.06746125827552
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/315	72/9376	1.65361552028219	NFKBIA/TNF/CXCL10/IRF7	1.03802210808848
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/315	73/9376	1.63096325288106	PLCG2/GRB2/CDKN1A/STAT3	1.00903640697223
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/315	76/9376	1.56658312447786	ATP1B3/GNAS/EZR/PRKACA	0.924659437838278
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/315	76/9376	1.56658312447786	PLCG2/PDGFB/GRB2/CDKN1A	0.924659437838278
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	15/315	368/9376	1.21325051759834	SQSTM1/MT-ND5/MT-CO3/HNRNPA2B1/MT-ND4L/MT-CO1/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/FUS/HNRNPA3/TNF/TNFRSF1B/MT-ND4	0.778130904841046
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/315	77/9376	1.54623788909503	NFKBIA/GRB2/CDKN1A/CRK	0.897350088034071
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/315	78/9376	1.52641432641433	PLCG2/SYNJ2/ITPK1/INPP5D	0.87042845585385
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/315	78/9376	1.52641432641433	FN1/ITGA5/CDC42/CRK	0.87042845585385
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/315	105/9376	1.41738473167045	SQSTM1/GABARAPL1/JUN/USP15/RABGEF1	0.801901022059582
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/315	55/9376	1.62354978354978	PSAP/SPHK1/HEXB	0.864717151997331
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/315	32/9376	1.86031746031746	GABARAPL1/PPP2CA	0.908908492345398
NA	NA	hsa04382	Cornified envelope formation	9/315	217/9376	1.23449637919684	PLEC/S100A10/COL4A1/KRT7/KRT19/KRT8/COL17A1/PPP2CA/LAMA3	0.651620634741919
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/315	59/9376	1.5134786117837	GNAS/CGA/PRKACA	0.737671774460845
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/315	86/9376	1.3844222960502	ATP1B3/GNAS/PRKACA/ATF6B	0.667732918225066
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/315	194/9376	1.22742595319915	DYNC1H1/MYO1G/DYNLRB1/TPM3/MYH9/KIFC3/TPM4/TPM1	0.596794887788974
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/315	12/9376	2.48042328042328	FCGR2B	0.95675045269379
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/315	89/9376	1.33775637595862	GNAS/PDGFB/GRB2/PRKACA	0.596916641166728
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/315	37/9376	1.60892320892321	CDKN1A/TPM3	0.691936199093627
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/315	117/9376	1.27201193867861	CHD4/INO80D/CHD3/BAZ1A/YY1	0.552016049165415
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/315	90/9376	1.32289241622575	ATP1B3/GNAS/LDLR/PRKACA	0.573875401750936
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/315	38/9376	1.56658312447786	ATP1B3/SGK1	0.652501250672546
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/315	148/9376	1.20669240669241	JUN/NFKB2/GRB2/CDKN1A/FGFR1/NOTCH1	0.472557256837093
NA	NA	hsa04519	Cadherin signaling	15/315	404/9376	1.10513908533711	NFKBIA/YWHAE/ACTN4/LHFPL2/CDC42/VIM/ROCK1/DSC2/MYO1G/KRT7/KRT19/VASP/FGFR1/CYFIP1/KRT8	0.402775545511636
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/315	149/9376	1.19859379993608	PLCG2/GNAS/RALGDS/PDGFB/GRB2/SPHK1	0.455597581045476
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/315	67/9376	1.33276474769012	LDHA/ALDH2/PKM	0.509654716918437
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/315	15/9376	1.98433862433862	HEXB	0.711347621084217
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/315	69/9376	1.29413388543823	CTSB/GNAS/PRKACA	0.457211976662739
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/315	125/9376	1.19060317460317	CTSD/ROCK1/SPHK1/TNF/PPP2CA	0.399984945403455
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/315	42/9376	1.41738473167045	AOC1/ALDH2	0.505452274212221
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/315	98/9376	1.21490119857467	PLCG2/SYNJ2/ITPK1/INPP5D	0.398728740929122
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/315	155/9376	1.15219662058372	GNAS/NR4A1/LDLR/CDKN1A/PRKACA/ATF6B	0.356233450335744
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/315	16/9376	1.86031746031746	MIF	0.642145811193634
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/315	16/9376	1.86031746031746	HEXB	0.642145811193634
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/315	43/9376	1.3844222960502	ALDH2/ACADVL	0.471069529156225
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/315	99/9376	1.20262946929614	RALGDS/JUN/PDGFB/GRB2	0.377893372977602
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	14/315	388/9376	1.07399770904926	APOE/MT-ND5/MT-CO3/MT-ND4L/MT-CO1/LRP1/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/TNF/SLC39A1/MT-ND4/CSNK1E	0.27755909009871
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/315	44/9376	1.35295815295815	MGAT4B/HEXB	0.437537258367683
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/315	44/9376	1.35295815295815	POLD4/HMGB1	0.437537258367683
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/315	158/9376	1.13031946955998	DDIT4/GRB2/TNF/FNIP1/EIF4E/SGK1	0.30801533928017
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/315	73/9376	1.2232224396608	SAMHD1/CHMP4A/AFF4	0.356977315941035
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/315	73/9376	1.2232224396608	PDGFB/CDKN1A/FGFR1	0.356977315941035
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/315	103/9376	1.15592541223609	ATP1B3/COL4A1/SLC38A2/COL17A1	0.296673143444335
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	11/315	308/9376	1.06303854875283	MT-ND5/MT-CO3/MT-ND4L/MT-CO1/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/AP2A2/POLR2J3/MT-ND4	0.209738742029352
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/315	75/9376	1.19060317460317	SERPINE1/CDKN1A/IGFBP3	0.308993105481056
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/315	76/9376	1.1749373433584	OLR1/SCD/PLTP	0.285496440995776
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/315	254/9376	1.05466816647919	PLCG2/VEGFA/GNAS/FLT1/PDGFB/PRKACA/SPHK1/FGFR1/P2RX7	0.164686948500946
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/315	107/9376	1.11271324729269	LDHA/GNAS/PRKACA/PKM	0.218626730327
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/315	50/9376	1.19060317460317	AOC1/ALDH2	0.25195343071217
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/315	50/9376	1.19060317460317	HLA-DRB1/HLA-DRB3	0.25195343071217
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/315	21/9376	1.41738473167045	ALDH2	0.357007351709689
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/315	115/9376	1.03530710835059	GNAS/ALOX5/PRKACA/ALOX15B	0.0710288819028377
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/315	23/9376	1.29413388543823	POLD4	0.263321524415158
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/315	23/9376	1.29413388543823	ANPEP	0.263321524415158
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/315	23/9376	1.29413388543823	ATP1B3	0.263321524415158
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/315	54/9376	1.10241034685479	LDHA/MAT2A	0.140714553694315
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/315	86/9376	1.03831672203765	LMNA/ITGA5/DSC2	0.0665552879890167
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/315	149/9376	0.998828166613402	MT-ND5/MT-ND4L/MT-ND6/PRKACA/MT-ND4	-0.0026883238877266
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/315	56/9376	1.06303854875283	PRKACA/CSNK1E	0.088215543397314
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/315	57/9376	1.04438874965191	SCD/ACADVL	0.06267271859715
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/315	89/9376	1.00331728196897	GABARAPL1/PRKACA/SLC38A2	0.00586263043917057
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/315	90/9376	0.992169312169312	PRKACA/ATF6B/EIF4E	-0.0139174502063258
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/315	184/9376	0.970600414078675	PLCG2/CDC42/ROCK1/EPHB6/PLXNB2/EPHB2	-0.0750927427563635
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/315	122/9376	0.975904241478012	PLCG2/ATP1B3/PRKACA/NOTCH1	-0.0499469093559095
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/315	154/9376	0.966398680684395	GNAS/JUN/ROCK1/CDKN1A/PRKACA	-0.0783893351684207
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/315	59/9376	1.00898574118913	GRB2/CDKN1A	0.0129090628036216
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/315	217/9376	0.960163850486431	VEGFA/GNAS/JUN/GRB2/PRKACA/ATF6B/STAT3	-0.110697048374961
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/315	27/9376	1.10241034685479	SCD	0.0993564324634727
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/315	60/9376	0.992169312169312	GNAS/PPP2CA	-0.01134523892591
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/315	93/9376	0.960163850486431	ATP1B3/GNAS/PRKACA	-0.0719825955906528
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/315	28/9376	1.06303854875283	TCIRG1	0.0622843189716321
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/315	158/9376	0.94193289129998	YWHAE/ORC6/CDKN1A/DDX11/PPP2CA	-0.137243960918855
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/315	62/9376	0.960163850486431	PRKACA/HSPA6	-0.0586756529991867
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/315	62/9376	0.960163850486431	LFNG/NOTCH1	-0.0586756529991867
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/315	191/9376	0.935028671154325	FOSB/GNAS/GRB2/PRKACA/ATF6B/HDAC7	-0.16914209387627
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/315	29/9376	1.0263820470717	CSNK1E	0.0265292039430554
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/315	63/9376	0.944923154446964	ALDH2/PLOD2	-0.0817800519025967
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/315	63/9376	0.944923154446964	POLR2J3/POLD4	-0.0817800519025967
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/315	226/9376	0.921927236971485	ATP1B3/GNAS/NFKBIA/JUN/CGA/ROCK1/PRKACA	-0.221511394900741
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/315	30/9376	0.992169312169312	TNF	-0.00800940952889223
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/315	65/9376	0.915848595848596	ALDH2/ABHD16A	-0.126932470223155
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/315	65/9376	0.915848595848596	SPP1/CGA	-0.126932470223155
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/315	99/9376	0.901972101972102	PLCG2/GNAS/PRKACA	-0.182816907927287
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/315	31/9376	0.960163850486431	ALDH2	-0.0414210780250809
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/315	31/9376	0.960163850486431	ALDH2	-0.0414210780250809
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/315	31/9376	0.960163850486431	BAG6	-0.0414210780250809
NA	NA	hsa04981	Folate transport and metabolism	1/315	31/9376	0.960163850486431	SLCO2B1	-0.0414210780250809
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/315	133/9376	0.895190356844492	GNAS/PRKACA/ATF6B/PPP2CA	-0.226972601894285
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/315	166/9376	0.896538535092752	ATP1B3/GTF2I/ROCK1/VASP/ATF6B	-0.250758522403412
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/315	134/9376	0.888509831793414	GNAS/ROCK1/PRKACA/MYH9	-0.242358824653201
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/315	32/9376	0.93015873015873	LDHA	-0.0737859292678921
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/315	138/9376	0.862755923625489	YWHAE/PRKACA/PPP2CA/REC8	-0.302828693571645
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/315	34/9376	0.875443510737628	POLR2J3	-0.135655915202713
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/315	140/9376	0.850430839002268	SPP1/SERPINE1/PRKACA/SPHK1	-0.332442824199639
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/315	36/9376	0.826807760141093	POLD4	-0.19411499767271
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/315	37/9376	0.804461604461605	MIF	-0.22219565981885
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/315	178/9376	0.836097734974139	NOTUM/JUN/PRKACA/FOSL1/CSNK1E	-0.411624393403019
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/315	75/9376	0.79373544973545	PKM/MAT2A	-0.334382279149275
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/315	38/9376	0.783291562238931	HEXB	-0.249570664146946
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/315	38/9376	0.783291562238931	NAPRT	-0.249570664146946
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/315	39/9376	0.763207163207163	MAT2A	-0.276280373488055
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	14/315	480/9376	0.868148148148148	SQSTM1/MT-ND5/MT-CO3/MT-ND4L/MT-CO1/MT-CYB/MT-ATP8/MT-ND6/MT-ATP6/FUS/TNF/TNFRSF1B/MT-ND4/CSNK1E	-0.552920020276942
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/315	79/9376	0.753546313039984	AP2A2/TCIRG1	-0.410138274222493
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/315	116/9376	0.769786535303777	GNAS/PRKACA/SLC38A2	-0.465165045107156
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/315	41/9376	0.725977545489741	POLD4	-0.327848928972637
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/315	154/9376	0.773118944547516	ALDH2/NAPRT/MAT2A/PDXK	-0.529296333045178
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/315	82/9376	0.725977545489741	CES1/TYMP	-0.464669956832456
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/315	83/9376	0.717230828074202	PHF1/YY1	-0.48244297571969
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/315	44/9376	0.676479076479076	GTF2I	-0.40104600705656
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/315	122/9376	0.731928181108509	SCD/SREBF1/PPP2CA	-0.555672851171253
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/315	45/9376	0.661446208112875	ABCG1	-0.424446243655214
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/315	86/9376	0.692211148025102	PRKACA/P2RY1	-0.534622342247033
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/315	48/9376	0.62010582010582	ALDH2	-0.491973646905022
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/315	48/9376	0.62010582010582	ATP1B3	-0.491973646905022
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/315	49/9376	0.607450599287334	LFNG	-0.513658193677408
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/315	91/9376	0.654177568463283	GNAS/PRKACA	-0.618067278709893
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/315	51/9376	0.583629007158419	PLD3	-0.555896556442759
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/315	170/9376	0.700354808590103	PLCG2/GRB2/NFE2L2/CDKN1A	-0.735104595931189
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/315	97/9376	0.613712976599575	GNAS/PRKACA	-0.713014314306081
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/315	56/9376	0.531519274376417	MGAT4B	-0.655587455607377
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/315	101/9376	0.589407512179789	GNAS/PRKACA	-0.773512928536014
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/315	102/9376	0.583629007158419	ATP1B3/GNAS	-0.788315119244131
NA	NA	hsa04081	Hormone signaling	5/315	219/9376	0.679568022033775	GNAS/CGA/PRKACA/HAMP/STAT3	-0.894610828909652
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/315	59/9376	0.504492870594565	TYMP	-0.711853648853601
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/315	59/9376	0.504492870594565	ANPEP	-0.711853648853601
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/315	61/9376	0.487952120739006	ATP1B3	-0.748060820979547
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/315	108/9376	0.551205173427396	DDX39B/PNN	-0.874620307945444
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/315	63/9376	0.472461577223482	CDKN1A	-0.783307743246371
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/315	67/9376	0.444254915896707	PRKACA	-0.851166193184728
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/315	75/9376	0.396867724867725	CDKN1A	-0.977757663779606
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/315	78/9376	0.381603581603582	BTG2	-1.02252125856219
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/315	85/9376	0.350177404295051	TYMP	-1.12208534763271
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/315	142/9376	0.419226469930695	HERC2/SOCS3	-1.30019622648749
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/315	150/9376	0.396867724867725	GRB2/CDKN1A	-1.38836713160002
NA	NA	hsa04082	Neuroactive ligand signaling	3/315	199/9376	0.448719789423307	GNAS/PRKACA/P2RY1	-1.46555264983854
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/315	104/9376	0.286202686202686	PLD3	-1.36476450044524
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/315	110/9376	0.270591630591631	PRKACA	-1.43474191710504
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/315	115/9376	0.258826777087647	PRKACA	-1.49105117295488
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/315	116/9376	0.256595511767926	PKM	-1.50210928260708
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/315	183/9376	0.325301413826004	RMRP/GNL2	-1.71853968244966
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/315	370/9376	0.482676962676963	C3AR1/CGA/C3/P2RX7/C5AR1/P2RY1	-1.89299540322496
Genetic Information Processing	Translation	hsa03010	Ribosome	2/315	222/9376	0.268153868153868	RPS9/RPS17	-2.05751810190066
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/315	449/9376	0.0662919362251211	PRKACA	-3.78037047405781