category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	36/645	82/9376	6.38184912081679	HLA-E/HLA-DRB1/HLA-A/CANX/CTSB/IFI30/HLA-DRA/TAPBP/HSPA1A/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/HSPA1B/PSME2/HLA-B/B2M/PSME1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TAP1/TNF/HLA-G/CTSL/TAP2/HSP90AA1/HLA-DOA/HSPA6/HSP90AB1/HLA-DQB2/HSPA5/LGMN/HSPA2	13.3036439059944
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	44/645	180/9376	3.55335055986219	HLA-E/HLA-DRB1/HLA-A/HLA-DRA/TAPBP/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/TNFRSF14/HLA-B/B2M/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/IRF7/TAP1/TNF/IFNGR2/HLA-G/TAP2/NFKBIA/IRF9/CCL5/SRSF1/HLA-DOA/DAXX/CCL2/CARD9/PIK3R2/SOCS3/SRSF2/HLA-DQB2/IL6/ITGA5/PIK3R3/SRSF6/TICAM1/BIRC3/SRSF7/SRSF8/IKBKB	9.40114427414482
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	30/645	95/9376	4.59045287637699	CCL3/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/ATP6V0C/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/TNFSF13/ITGB2/CTSL/VEGFA/JUN/CCL20/CCL5/HLA-DOA/FLT1/CCL2/CXCL3/CXCL1/HLA-DQB2/IL6/LTB/CXCL8/TLR4/TNFRSF11A	9.55976351054853
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	39/645	155/9376	3.65755438859715	HLA-E/HLA-DRB1/HLA-A/CANX/HLA-DRA/TUBB/HLA-DPB1/HLA-DPA1/HLA-C/ATP6V0C/HLA-F/HLA-DQA1/HLA-B/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TAP1/HLA-G/ITGB2/CTSL/TAP2/FCGR3A/TUBB4B/HLA-DOA/LAMP1/RILP/DYNC1H1/TUBA1C/HLA-DQB2/ITGA5/ITGAM/FCAR/MRC2/TLR4/RAB5B/TUBB3/COLEC12/TUBA1B	9.0676030711079
Human Diseases	Immune disease	hsa05330	Allograft rejection	18/645	39/9376	6.70912343470483	HLA-E/HLA-DRB1/HLA-A/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/HLA-B/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/HLA-G/HLA-DOA/HLA-DQB2	9.71027564413553
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	19/645	44/9376	6.27709654686399	HLA-E/HLA-DRB1/HLA-A/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/HLA-B/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/HLA-G/HLA-DOA/HLA-DQB2/HSPD1	9.53602793117247
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	19/645	45/9376	6.13760551248923	HLA-E/HLA-DRB1/HLA-A/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/HLA-B/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/HLA-G/HLA-DOA/HLA-DQB2/IL6	9.3893692318049
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	19/645	56/9376	4.93200442967885	HSPA1A/HSPA1B/EEF1G/TNF/NAIP/ITGB2/NFKBIA/CLK1/HSF1/HSPA6/NFKB2/CXCL3/CXCL1/HSPD1/IL6/CXCL8/ITGAM/VCP/TLR4	8.02109309956917
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	39/645	205/9376	2.76546795235394	HLA-E/HLA-DRB1/HLA-A/PLCG2/HLA-DRA/TAPBP/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/HLA-B/B2M/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/IRF7/TAP1/TNF/PSMC4/HLA-G/TAP2/NFKBIA/NFKBIB/JUN/IRF9/NFKBIE/HLA-DOA/NFKB2/PIK3R2/TNFAIP3/ISG15/HLA-DQB2/IL6/PIK3R3/CDKN1A/IKBKB/USP7	6.94643415896765
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	28/645	119/9376	3.4203374373005	TNF/ATF6B/NFKBIA/CEBPB/JUN/MMP14/ATF4/CCL20/CFLAR/CCL5/CCL2/PIK3R2/CXCL3/RIPK3/CXCL1/TNFAIP3/SOCS3/MMP9/IL6/JAG1/PIK3R3/BIRC3/MAPK3/TAB3/PTGS2/ITCH/IKBKB/IRF1	7.2218384415353
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	41/645	224/9376	2.66068660022148	HLA-E/HLA-DRB1/HLA-A/CANX/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/HLA-B/B2M/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/GPS2/TNF/PRKACA/HLA-G/ITGB2/ATF6B/NFKBIA/JUN/ATF4/HLA-DOA/MAD1L1/HRAS/NFKB2/PIK3R2/SPI1/HLA-DQB2/IL6/ETS2/PIK3R3/KAT5/CDKN1A/CDKN2B/MAPK3/IL2RA/IKBKB	6.83734015292131
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	22/645	78/9376	4.10001987676406	HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/IFNGR2/ITGB2/NFKBIA/NFKBIB/JUN/FCGR3A/HLA-DOA/HLA-DQB2/ITGAM/MAPK3/TLR4/PTGS2	7.47223480034037
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	20/645	70/9376	4.15326688815061	HLA-E/HLA-DRB1/HLA-A/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/HLA-B/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/HLA-G/ITGB2/HLA-DOA/EIF4G2/HLA-DQB2/EIF4G1	7.19716944795519
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	34/645	181/9376	2.73060088226477	HLA-DRB1/LSP1/HLA-DRA/HLA-DPB1/HLA-DPA1/ATP6V0C/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/IFNGR2/ITGB2/CEBPB/IL10RB/FCGR3A/HLA-DOA/CTSD/PLK3/LAMP1/CARD9/HLA-DQB2/HSPD1/IL6/CALML4/ITGAX/ITGAM/MRC2/MAPK3/HSPA9/TLR4/RAB5B/CAMK2G	6.38989678079452
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	17/645	54/9376	4.57628481194373	HLA-E/HLA-DRB1/HLA-A/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/HLA-B/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/HLA-G/HLA-DOA/HLA-DQB2	7.16321407398906
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	25/645	109/9376	3.33404452030439	HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/IFNGR2/NFKBIA/NFKBIB/HSP90AA1/JUN/NFKBIE/AHR/HLA-DOA/IL27RA/HSP90AB1/HLA-DQB2/IL6/RXRB/MAPK3/IL2RA/IKBKB	6.66171892165661
Human Diseases	Immune disease	hsa05310	Asthma	13/645	32/9376	5.90542635658915	PRG2/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/HLA-DOA/HLA-DQB2	7.55472805620779
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	29/645	142/9376	2.96870837427667	PLCG2/LILRB4/SQSTM1/LILRB3/FOSB/TNF/IFNGR2/LILRB2/NFKBIA/OSCAR/JUN/IRF9/FCGR3A/LILRA6/LILRA2/NFKB2/PIK3R2/SOCS3/LILRB5/SPI1/FOSL2/LILRB1/SIRPA/LILRA4/PIK3R3/MAPK3/LILRA1/IKBKB/TNFRSF11A	6.42486678248462
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	44/645	275/9376	2.32582945736434	TUBB/HSPA1A/MT-CO3/HSPA1B/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/PSMB3/NDUFA3/PSMA6/MT-CO2/MT-ND5/TNF/NDUFA7/MT-ND2/NDUFA6/MT-CYB/PSMA2/PSMC4/PRKACA/CSNK2B/ATF6B/MT-ND4L/NDUFS1/NDUFS3/ATF4/NDUFA13/TUBB4B/CCL5/HSPA6/MT-ND3/PPIF/PIK3R2/TUBA1C/IL6/MT-ND6/HSPA5/PIK3R3/COX4I2/MAPK3/TUBB3/PRNP/TUBA1B	6.06516967800716
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	25/645	112/9376	3.24473975636766	HLA-DRB1/HLA-DRA/HSPA1A/HLA-DPB1/HLA-DPA1/HLA-DQA1/HSPA1B/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/ALOX5/IFNGR2/NFKBIA/NFKBIB/IL10RB/HLA-DOA/HSPA6/PPIF/HLA-DQB2/BIRC3/MAPK3/TLR4/IKBKB	6.49544990841912
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	22/645	94/9376	3.40214415305954	FOSB/TNF/NFKBIA/CEBPB/HSP90AA1/JUN/CCL20/SRSF1/CCL2/CXCL3/HSP90AB1/CXCL1/TNFAIP3/MMP9/IL6/CXCL8/HSP90B1/MAPK3/TAB3/ELAVL1/PTGS2/IKBKB	6.36173701587668
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	35/645	205/9376	2.48183021365097	HLA-E/HLA-A/HLA-C/YWHAE/HLA-F/CDC42/HLA-B/ACTN4/IRF7/PRKACA/HLA-G/ATF6B/NFKBIA/MRPS18B/JUN/IRF9/CHD4/ATF4/MAD1L1/GTF2H1/PKM/SCRIB/HRAS/NFKB2/PIK3R2/DNAJA3/GTF2H2/PIK3R3/ACTN1/GTF2H4/DDX3X/CDKN1A/CDKN2B/MAPK3/USP7	5.8304292639076
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	36/645	216/9376	2.42273901808786	CCL3/HSPA1A/HSPA1B/CDC42/IRF7/TNF/NFKBIA/HSP90AA1/JUN/ATF4/CCL5/SOD2/HSPA6/CCL2/HRAS/PIK3R2/CXCL3/HSP90AB1/CXCL1/MMP9/HSPD1/IL6/CALML4/RXRB/CXCL8/HSPA5/AGER/HSP90B1/TICAM2/PIK3R3/TICAM1/MAPK3/TLR4/HSPA2/CAMK2G/IKBKB	5.74960331422225
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	31/645	173/9376	2.60479455123897	HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/IRF7/TNF/IFNGR2/NFKBIA/NFKBIB/IRF9/DNAJB1/CCL5/PABPN1/HLA-DOA/CCL2/PIK3R2/SOCS3/HLA-DQB2/IL6/CXCL8/MX1/PIK3R3/TICAM1/MAPK3/TLR4/IKBKB	5.79043622974227
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	21/645	93/9376	3.28242060515129	HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/IFNGR2/NFKBIA/NFKBIB/JUN/NFKBIE/HLA-DOA/MAML1/HLA-DQB2/JAG1/MAPK3/IL2RA/IKBKB	6.01210393405892
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	32/645	187/9376	2.48751813621855	CTSB/YWHAE/GABARAP/IRF7/TNF/NAIP/GPSM3/NFKBIA/NFKBIB/GSDMD/HSP90AA1/JUN/IRF9/CCL5/CCL2/CARD9/CXCL3/HSP90AB1/RIPK3/CXCL1/TNFAIP3/IL6/RNF31/CXCL8/ATG16L1/TICAM1/BIRC3/PSTPIP1/MAPK3/TAB3/TLR4/IKBKB	5.58447625123293
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	40/645	268/9376	2.16961703112345	TUBB/MT-CO3/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/PSMB3/NDUFA3/PSMA6/MT-CO2/MT-ND5/SLC39A1/NDUFA7/MT-ND2/NDUFA6/MT-CYB/PSMA2/PSMC4/PRKACA/SLC39A7/MT-ND4L/NDUFS1/NDUFS3/ATF4/NDUFA13/TUBB4B/DAXX/MT-ND3/PPIF/SLC39A4/TUBA1C/CALML4/MT-ND6/HSPA5/COX4I2/TUBB3/SLC39A13/CAMK2G/GNAS/TUBA1B	5.27998964729582
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	20/645	91/9376	3.19482068319278	PLCG2/LILRB4/LILRB3/LILRB2/INPP5D/NFKBIA/NFKBIB/JUN/NFKBIE/LILRA6/LILRA2/HRAS/PIK3R2/LILRB5/LILRB1/LILRA4/PIK3R3/MAPK3/LILRA1/IKBKB	5.71823879587367
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	38/645	250/9376	2.20953798449612	CTSB/ATP6V0C/CLN8/NEU1/PSAP/MAN2B1/IDS/CTSL/CLN6/LAPTM5/CLN3/HEXA/SLC2A6/AP2A2/VPS11/CTSD/BORCS5/LAMP1/SCARB2/CTSA/CTSO/SLC15A3/CTSZ/GAA/PLEKHM1/GM2A/SLC11A1/HEXB/VPS13A/AP1B1/LGMN/AP5B1/TPP1/GGA3/AP5S1/NAGLU/MLST8/CTNS	5.26844905774727
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	14/645	50/9376	4.0702015503876	HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNFSF13/HLA-DOA/HLA-DQB2/IL6/ICOSLG	5.91612967499047
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	35/645	227/9376	2.24130041320903	CCL3/HLA-E/HLA-A/TAPBP/CCL4/HLA-C/HLA-F/HLA-B/B2M/TAP1/TNF/PRKACA/GNG10/HLA-G/ATF6B/TAP2/NFKBIA/VEGFA/IL10RB/ATF4/CCL5/CCL2/HRAS/PIK3R2/IL6/CALML4/CXCL8/PIK3R3/SP1/CDKN1A/MAPK3/PTGS2/PTGER4/IKBKB/GNAS	5.14560584630063
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	16/645	66/9376	3.52398402630961	HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/IFNGR2/JUN/HLA-DOA/HLA-DQB2/IL6/TLR4	5.59264471533621
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	21/645	105/9376	2.90728682170543	PLCG2/CCL4/TNF/CSNK2B/NFKBIA/CFLAR/NFKB2/CXCL3/CXCL1/TNFAIP3/BCL2A1/LTB/CXCL8/TICAM2/TICAM1/BIRC3/TAB3/TLR4/PTGS2/IKBKB/TNFRSF11A	5.34171691076348
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	27/645	157/9376	2.49989631165753	MT-CO3/MT-CO1/CDC42/NDUFA3/MT-CO2/TNF/NDUFA7/NDUFA6/MT-CYB/ADIPOR2/NDUFS1/NDUFS3/JUN/ATF4/NDUFA13/PIK3R2/SOCS3/PRKAG1/IL6/CXCL8/PIK3R3/SREBF1/COX4I2/NR1H3/MLXIP/ITCH/IKBKB	5.1511317424267
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	20/645	99/9376	2.93665335525801	HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/CFD/C2/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/ITGB2/FCGR3A/HLA-DOA/HLA-DQB2/DEFB1/CFB/ITGAM/FCAR/C5AR1	5.26501015291913
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	27/645	160/9376	2.45302325581395	HLA-E/HLA-DRB1/HLA-A/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-C/HLA-F/HLA-DQA1/HLA-B/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/HLA-G/ITGB2/HLA-DOA/SIGLEC1/CLDN7/F11R/HLA-DQB2/CLDN23/ICOSLG/PTPRC/ITGAM/PTPRF/CD99L2	5.03842531063784
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	36/645	248/9376	2.11012753188297	TUBB/CDC42/TNF/DYNLRB1/NAIP/CYFIP1/NFKBIA/GSDMD/HSP90AA1/JUN/ARPC1B/TUBB4B/SKP1/FLNA/VPS11/RILP/HRAS/HSP90AB1/DYNC1H1/RIPK3/TUBA1C/IL6/CXCL8/HSP90B1/PLEKHM1/PTPRC/BIRC3/FBXO22/AHNAK/MAPK3/TAB3/TLR4/RAB5B/TUBB3/IKBKB/TUBA1B	4.81553340291483
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/645	110/9376	2.77513742071882	PLCG2/LDHA/IFNGR2/VEGFA/EGLN2/FLT1/SERPINE1/PIK3R2/HMOX1/EGLN1/EIF4E/IL6/ANGPT2/PIK3R3/HK3/CDKN1A/MAPK3/TLR4/ENO2/MKNK1/CAMK2G	5.08997530496361
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	49/645	388/9376	1.83578678174698	TUBB/MT-CO3/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/PSMB3/NDUFA3/PSMA6/MT-CO2/MT-ND5/TNF/SLC39A1/NDUFA7/MT-ND2/NDUFA6/MT-CYB/PSMA2/PSMC4/CSNK2B/SLC39A7/MT-ND4L/NDUFS1/NDUFS3/ATF4/NDUFA13/TUBB4B/LRP1/MT-ND3/PPIF/HRAS/PIK3R2/SLC39A4/PSEN2/TUBA1C/IL6/CALML4/MT-ND6/AGER/CSNK1E/PIK3R3/COX4I2/MAPK3/PTGS2/TUBB3/SLC39A13/IDE/IKBKB/TUBA1B	4.56996980602003
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	27/645	174/9376	2.25565356856455	CANX/HSPA1A/HSPA1B/ATF6B/HSP90AA1/HYOU1/DNAJB1/ATF4/HSPH1/RNF5/SKP1/TXNDC5/HSPA6/RRBP1/BCAP29/PPP1R15A/HSP90AB1/NPLOC4/HSPA5/HSP90B1/KRTCAP2/P4HB/ERO1B/VCP/NSFL1C/MBTPS1/MOGS	4.54398455286308
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	23/645	137/9376	2.44042324449726	CTSB/TNF/CTSL/NFKBIA/LMNA/JUN/ATF4/CFLAR/MCL1/DAXX/CTSD/HRAS/PIK3R2/CTSO/TUBA1C/BCL2A1/CTSZ/PIK3R3/BIRC3/MAPK3/CASP2/IKBKB/TUBA1B	4.61605975901384
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/645	103/9376	2.68147813652442	CCL3/TNF/IFNGR2/NFKBIA/JUN/PPP2CA/CFLAR/CCL5/CCL2/SERPINE1/PIK3R2/IL6/CXCL8/PIK3R3/TICAM1/MAPK3/TLR4/IKBKB/GNAS	4.66372794901485
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	29/645	196/9376	2.15079892422085	HLA-E/HLA-A/PLCG2/HLA-C/HLA-F/HLA-B/IRF7/GNG10/HLA-G/NFKBIA/VEGFA/JUN/IRF9/PDGFB/HRAS/PIK3R2/CXCL3/CXCL1/IL6/CALML4/CXCL8/ANGPT2/PIK3R3/MICB/TICAM1/CDKN1A/MAPK3/PTGS2/IKBKB	4.42526867709752
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/645	101/9376	2.59065162330186	PLCG2/FN1/CDC42/TNF/VEGFA/JUN/COL4A1/CCL2/SERPINE1/HRAS/PIK3R2/THBD/IL6/CXCL8/AGER/PIM1/PIK3R3/MAPK3	4.36829844682586
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/645	227/9376	1.98515179455657	MT-CO3/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/NDUFA3/MT-CO2/MT-ND5/NDUFA7/MT-ND2/NDUFA6/MT-CYB/MT-ND4L/NDUFS1/NFKBIA/VEGFA/NDUFS3/JUN/NDUFA13/AHR/SOD2/MT-ND3/PPIF/HRAS/PIK3R2/HMOX1/MT-ND6/PIK3R3/COX4I2/MAPK3/IKBKB	4.08378405390106
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	18/645	105/9376	2.49196013289037	PLCG2/LSP1/TNF/NFKBIA/JUN/IRF9/PLK3/CARD9/HRAS/NFKB2/PIK3R2/IL6/CALML4/PIK3R3/MAPK3/PTGS2/IKBKB/IRF1	4.17851608963525
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	18/645	109/9376	2.40051205461916	CCL3/CCL4/IRF7/TNF/NFKBIA/JUN/IRF9/CCL5/PIK3R2/IL6/CXCL8/TICAM2/PIK3R3/TICAM1/TOLLIP/MAPK3/TLR4/IKBKB	3.99727493331957
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/645	109/9376	2.40051205461916	TNF/RPS6KA1/NFKBIA/PCK2/PIK3R2/SOCS3/PRKAG1/PPP1R3B/IL6/SLC27A3/PIK3R3/SREBF1/PTPRF/SLC27A1/NR1H3/MLXIP/CPT1A/IKBKB	3.99727493331957
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	17/645	100/9376	2.47119379844961	HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/HLA-DOA/ANPEP/HLA-DQB2/IL6/ITGA5/ITGAM/IL2RA	4.01997189662228
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/645	103/9376	2.39921728004817	FN1/ACTN4/TNF/PRKACA/ITGB2/COL4A1/PIK3R2/CXCL3/CXCL1/IL6/CXCL8/PIK3R3/ACTN1/ITGAM/TLR4/RAB5B/GNAS	3.88085256296783
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	30/645	235/9376	1.85571499257793	MT-CO3/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/NDUFA3/MT-CO2/MT-ND5/NDUFA7/MT-ND2/NDUFA6/MT-CYB/PRKACA/RPS6KA1/MT-ND4L/NDUFS1/NDUFS3/NDUFA13/SMARCB1/MT-ND3/COX16/HRAS/PRKAG1/MT-ND6/SMARCE1/COX4I2/CPT1A/MLST8/GNAS/COX18	3.61076911637402
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	42/645	368/9376	1.65904954499494	TUBB/CHCHD10/MT-CO3/SQSTM1/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/PSMB3/NDUFA3/PSMA6/MT-CO2/MT-ND5/TNF/NDUFA7/MT-ND2/NDUFA6/MT-CYB/PSMA2/FUS/PSMC4/HNRNPA2B1/MT-ND4L/NDUFS1/NDUFS3/ATF4/NDUFA13/TUBB4B/SMCR8/DAXX/MT-ND3/TUBA1C/MT-ND6/HSPA5/VCP/POM121/COX4I2/SRSF7/GLE1/NUP43/TUBB3/TUBA1B	3.5055913332147
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/645	78/9376	2.60910355794077	C2/TNF/ITGB2/JUN/IL6/CALML4/ITGA5/CXCL8/TICAM2/ITGAM/TICAM1/MAPK3/TLR4/IRF1	3.87855564834225
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	27/645	205/9376	1.91455473624504	MT-CO3/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/NDUFA3/MT-CO2/MT-ND5/NDUFA7/MT-ND2/NDUFA6/MT-CYB/MT-ND4L/NDUFS1/NDUFS3/NDUFA13/CTSD/MT-ND3/PPIF/PIK3R2/MMP9/MT-ND6/AGER/PIK3R3/SP1/COX4I2/CAMK2G	3.5984194737875
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	22/645	157/9376	2.03695255023947	ALOX5/DUSP2/CEBPB/STAB1/DUSP8/SLC16A1/LRP1/VPS11/DUSP16/SIRPA/AGER/ADAM9/SCARF1/SIGLEC10/BSG/NR1H3/MAPK3/RAB5B/PTGS2/CPT1A/PTGER4/CAMK2G	3.56123230346903
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/645	90/9376	2.42273901808786	IFNGR2/CSNK2B/NFKBIA/NFKBIB/JUN/NFKBIE/HRAS/PIK3R2/TICAM2/PIK3R3/TICAM1/MAPK3/TLR4/BATF/IKBKB	3.68608765492607
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	20/645	138/9376	2.10672958094596	ATP6V0C/MT-CO3/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/NDUFA3/MT-CO2/MT-ND5/NDUFA7/MT-ND2/NDUFA6/MT-CYB/MT-ND4L/NDUFS1/NDUFS3/NDUFA13/MT-ND3/MT-ND6/COX4I2	3.55979987676452
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	16/645	100/9376	2.32582945736434	CCL3/CCL4/TNFRSF14/TNF/IL10RB/CCL20/CCL5/CCL18/CCL2/CXCL3/CXCL1/IL6/CXCL8/ACKR3/CCL8/IL2RA	3.62277027264207
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	20/645	139/9376	2.09157325302549	HSPA1A/HSPA1B/PRKACA/ATF6B/HSP90AA1/JUN/ATF4/CTSD/HSPA6/HRAS/PIK3R2/HSP90AB1/MMP9/CALML4/HSP90B1/PIK3R3/SP1/GABBR1/MAPK3/GNAS	3.52393845781389
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	38/645	333/9376	1.65881230067277	HLA-E/HLA-A/FN1/HLA-C/ATP6V0C/HLA-F/CDC42/HLA-B/TNF/PRKACA/HLA-G/VEGFA/IRF9/PPP2CA/CHD4/COL4A1/HES4/PKM/SCRIB/HRAS/MAML1/PIK3R2/ISG15/ITGA5/PPP2R3B/MX1/JAG1/LFNG/PIK3R3/TICAM1/RFNG/CDKN1A/MAPK3/PTGS2/PTGER4/IKBKB/IRF1/GNAS	3.32706321018471
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/645	144/9376	2.01894918173988	C2/TNF/ADIPOR2/NFKBIA/SCD/CXCL3/CXCL1/PRKAG1/IL6/CXCL8/SREBF1/TICAM1/TRA2B/ACACA/TAB3/TLR4/C5AR1/CPT1A/ACADVL/IKBKB	3.34903259528665
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	19/645	138/9376	2.00139310189866	FLOT1/PRKACA/PCK2/HRAS/PIK3R2/EIF4E/SOCS3/PRKAG1/PPP1R3B/CALML4/PIK3R3/SREBF1/HK3/PTPRF/ACACA/MAPK3/PHKG2/MKNK1/IKBKB	3.22098469409734
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/645	120/9376	2.05932816537468	PLCG2/YWHAE/CDC42/RPS6KA1/NFKBIA/NFKBIB/JUN/ATF4/NFKBIE/HRAS/PIK3R2/PSEN2/CALML4/PIK3R3/MAPK3/CAMK2G/IKBKB	3.17426346783764
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/645	46/9376	2.84408493427705	PSME2/PSMB3/PSME1/PSMA6/PSMB8/PSMA2/PSMC4/PSMB9/PSMB10	3.40763064443224
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	34/645	308/9376	1.60467129769455	TUBB/MT-CO3/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/PSMB3/NDUFA3/PSMA6/MT-CO2/MT-ND5/NDUFA7/POLR2J3/MT-ND2/NDUFA6/MT-CYB/PSMA2/PSMC4/POLR2A/MT-ND4L/NDUFS1/NDUFS3/NDUFA13/TUBB4B/SOD2/AP2A2/MT-ND3/PPIF/TUBA1C/MT-ND6/SP1/COX4I2/TUBB3/TUBA1B	2.9327325413559
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	48/645	480/9376	1.45364341085271	TUBB/MT-CO3/SQSTM1/MT-ND1/MT-CO1/MT-ATP6/MT-ND4/PSMB3/NDUFA3/PSMA6/MT-CO2/MT-ND5/TNF/NDUFA7/MT-ND2/NDUFA6/MT-CYB/PSMA2/FUS/PSMC4/CSNK2B/MT-ND4L/NDUFS1/NDUFS3/ATF4/NDUFA13/TUBB4B/SMCR8/DAXX/MT-ND3/PPIF/HRAS/PSEN2/TUBA1C/IL6/CALML4/MT-ND6/HSPA5/AGER/CSNK1E/VCP/COX4I2/MAPK3/PTGS2/TUBB3/PRNP/CAMK2G/TUBA1B	2.77313709433661
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/645	169/9376	1.80630246318976	CTSB/SQSTM1/GABARAP/PRKACA/CTSL/PPP2CA/CFLAR/SMCR8/VPS11/CTSD/LAMP1/HRAS/PIK3R2/ATG9A/PLEKHM1/PIK3R3/ATG16L1/ATG4B/MAPK3/DDIT4/MLST8	2.87485383329317
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/645	18/9376	4.03789836347976	NEU1/MAN2B1/HEXA/HEXD/HEXB	3.50631939076289
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/645	214/9376	1.69818155473448	HLA-E/HLA-A/PLCG2/TAPBP/HLA-C/HLA-F/HLA-B/B2M/TAP1/TNF/GNG10/HLA-G/TAP2/NFKBIA/JUN/SKP1/HRAS/PIK3R2/CALML4/PIK3R3/SAMHD1/AP1B1/MAPK3/TLR4/IKBKB	2.80810676236789
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/645	50/9376	2.61655813953488	TNF/HBA2/ITGB2/HBA1/LRP1/CCL2/IL6/CXCL8/TLR4	3.11502923299688
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	27/645	238/9376	1.64909126441274	PLCG2/RPS18/CFD/RPS9/RPS17/RPL7A/C2/RPS25/RPL36A/TNF/RPL17/NFKBIA/NFKBIB/JUN/IRF9/CCL2/PIK3R2/ISG15/IL6/CXCL8/MX1/PIK3R3/CFB/MAPK3/TLR4/C5AR1/IKBKB	2.75678036851652
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/645	70/9376	2.28429678848283	TNF/ADIPOR2/NFKBIA/NFKBIB/PCK2/NFKBIE/SOCS3/PRKAG1/RXRB/CPT1A/IKBKB	2.93134134725806
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/645	70/9376	2.28429678848283	CDC42/VEGFA/JUN/EGLN2/PDGFB/HRAS/PIK3R2/EGLN1/PIK3R3/CDKN1A/MAPK3	2.93134134725806
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	20/645	163/9376	1.78361154705854	IRF7/TNF/ATF6B/NFKBIA/JUN/ATF4/HRAS/PIK3R2/MMP9/IL6/HSPG2/CXCL8/TICAM2/PIK3R3/TICAM1/DDX3X/CDKN1A/MAPK3/TLR4/IKBKB	2.74301128937252
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/645	71/9376	2.25212359427885	PLCG2/ATP6V0C/CDC42/NFKBIA/JUN/CCL5/CXCL3/CXCL1/F11R/CXCL8/IKBKB	2.87840358061933
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	37/645	362/9376	1.48576812711465	FN1/YWHAE/GNG10/ATF6B/VEGFA/HSP90AA1/PPP2CA/PCK2/ATF4/EREG/MCL1/COL4A1/FLT1/PDGFB/HRAS/CSH1/PIK3R2/SGK3/HSP90AB1/EIF4E/IL6/ITGA5/AREG/PPP2R3B/ANGPT2/HSP90B1/PIK3R3/CDC37/CDKN1A/MAPK3/IL2RA/TLR4/LPAR6/DDIT4/NR4A1/MLST8/IKBKB	2.56187553104662
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/645	63/9376	2.30737049341701	POLR2J3/POLR2A/POLD4/GTF2H1/ERCC5/CDK7/GTF2H2/GTF2H4/CETN2/POLD2	2.82981245427836
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	23/645	200/9376	1.67168992248062	TUBB/CDC42/TNF/NAIP/CYFIP1/NFKBIA/NFKBIB/JUN/ARPC1B/TUBB4B/CLDN7/TUBA1C/IL6/CLDN23/CXCL8/CTTN/NCL/MAPK3/TAB3/TLR4/TUBB3/IKBKB/TUBA1B	2.60970026293642
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/645	156/9376	1.77046312860266	YWHAE/IRF7/TNF/NFKBIA/IRF9/PPP2CA/CFLAR/HRAS/PIK3R2/CLDN7/SOCS3/CLDN23/MX1/PIK3R3/TICAM1/CDKN1A/NR1H3/MAPK3/IKBKB	2.63743764030539
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	19/645	157/9376	1.75918629338863	HLA-E/HLA-A/HLA-C/HLA-F/SQSTM1/HLA-B/HLA-G/RAD50/SERPINE1/HRAS/PIK3R2/IL6/CALML4/CXCL8/PIK3R3/HUS1/CDKN1A/CDKN2B/MAPK3	2.60729264009443
Human Diseases	Infectious disease: viral	hsa05162	Measles	17/645	136/9376	1.81705426356589	HSPA1A/HSPA1B/IRF7/CSNK2B/NFKBIA/NFKBIB/JUN/IRF9/HSPA6/PIK3R2/TNFAIP3/IL6/MX1/PIK3R3/IL2RA/TLR4/IKBKB	2.60866235216364
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/645	116/9376	1.87971130713713	PLCG2/CDC42/ACTN4/ITGB2/PIK3R2/CLDN7/F11R/CTNND1/MMP9/CLDN23/PIK3R3/ARHGAP35/ACTN1/ITGAM/CD99L2	2.59117757679819
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/645	138/9376	1.79072014380407	FN1/CDC42/TNF/RPS6KA1/NFKBIA/JUN/ARPC1B/CCL2/PIK3R2/IL6/ITGA5/CXCL8/PIK3R3/TICAM1/MAPK3/TLR4/IKBKB	2.54335432876297
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/645	47/9376	2.47428665677058	TNF/PKM/PIK3R2/SOCS3/PIK3R3/HK3/MAPK3/IKBKB	2.75389145669949
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/645	30/9376	2.90728682170543	TNF/ABCC1/IL6/SHMT1/FPGS/IKBKB	2.84378820425784
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/645	15/9376	3.87638242894057	HEXA/B3GALT4/ST6GALNAC6/HEXB	3.03015354242907
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	17/645	142/9376	1.74027732285184	SQSTM1/TNF/CTSL/VEGFA/HSP90AA1/JUN/PDGFB/CCL2/PIK3R2/HMOX1/HSP90AB1/THBD/MMP9/CALML4/HSP90B1/PIK3R3/IKBKB	2.41589015598357
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/645	90/9376	1.93819121447028	PRKACA/ADIPOR2/ATF6B/ATF4/SESN2/SOD2/EHMT2/HRAS/PIK3R2/EIF4E/PRKAG1/PIK3R3	2.43070233518082
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	16/645	133/9376	1.74874395290552	GABARAP/PCK2/SOD2/PLK3/HRAS/PIK3R2/SGK3/PRKAG1/IL6/CSNK1E/PIK3R3/CDKN1A/CDKN2B/MAPK3/IKBKB/USP7	2.36366635442247
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/645	32/9376	2.72558139534884	GABARAP/PPP2CA/ATG9A/ATG16L1/ATG4B/MLST8	2.65752601977221
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/645	41/9376	2.48183021365097	TYMP/VEGFA/HRAS/MMP9/CXCL8/CDKN1A/MAPK3	2.58444154765827
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/645	71/9376	2.04738508570805	LDHA/PKM/SLC16A3/HRAS/TIGAR/PIK3R2/PIK3R3/HK3/SLC7A5/MAPK3	2.40774712238025
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	13/645	103/9376	1.83469556709566	DDX39B/FUS/PPP2CA/PABPN1/CPSF1/PPP2R3B/RBM8A/SMG5/NUDT21/GLE1/CPSF7/CPSF2/UPF2	2.31510179087379
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	21/645	193/9376	1.58168454030606	CCL3/PLCG2/CCL4/CDC42/PRKACA/GNG10/NFKBIA/NFKBIB/CCL20/CCL5/CCL18/CCL2/HRAS/PIK3R2/CXCL3/CXCL1/CXCL8/PIK3R3/CCL8/MAPK3/IKBKB	2.21925591081431
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/645	62/9376	2.11012753188297	HSPA1A/HSPA1B/PRKACA/SOD2/HSPA6/HRAS/PIK3R2/PRKAG1/PIK3R3	2.38360398558568
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/645	253/9376	1.49386279376168	PLCG2/SQSTM1/CDC42/ACTN4/TNF/NAIP/NFKBIA/NFKBIB/JUN/ARPC1B/CCL5/SKP1/UBE2V1/PIK3R2/RNF31/ITGA5/CXCL8/PIK3R3/ACTN1/ATG16L1/HK3/CTTN/MAPK3/TAB3/TLR4/IKBKB	2.16436864352987
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/645	83/9376	1.9265153637807	CCL4/IRF7/NFKBIA/NFKBIB/GSDMD/CCL5/RIPK3/IL6/POLR3E/SAMHD1/IKBKB	2.3043434262067
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	17/645	149/9376	1.65851932781853	MT-ND1/MT-ND4/NDUFA3/MT-ND5/NDUFA7/MT-ND2/NDUFA6/PRKACA/GNG10/MT-ND4L/NDUFS1/NDUFS3/NDUFA13/MT-ND3/MT-ND6/MAPK3/PTGS2	2.20224129262665
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/645	44/9376	2.31261451726568	MGAT4B/HEXA/KRTCAP2/HEXD/HEXB/ALG9/MGAT1	2.37197265358856
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/645	106/9376	1.7827702208571	NFKBIA/HSP90AA1/ATF4/PDGFB/HRAS/PIK3R2/HSP90AB1/MMP9/HSP90B1/PIK3R3/CDKN1A/MAPK3/IKBKB	2.20282939054828
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	16/645	143/9376	1.62645416598905	HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA1/ACTN4/C2/HLA-DQB1/HLA-DRB5/HLA-DMA/HLA-DMB/TNF/FCGR3A/HLA-DOA/HLA-DQB2/ACTN1	2.05172619874894
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/645	19/9376	3.06030191758466	IDS/HEXA/HEXB/NAGLU	2.44327782783992
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/645	88/9376	1.81705426356589	CFD/C2/ITGB2/SERPINA1/SERPINE2/SERPINE1/THBD/ITGAX/CFB/ITGAM/C5AR1	2.09297786191976
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	15/645	133/9376	1.63944745584892	HLA-E/HLA-A/PLCG2/HLA-C/HLA-B/TNF/IFNGR2/HLA-G/ITGB2/FCGR3A/HRAS/PIK3R2/PIK3R3/MICB/MAPK3	2.01863458255118
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/645	168/9376	1.55747508305648	SQSTM1/TNF/CHMP4A/IFNGR2/HSP90AA1/IRF9/CFLAR/CHMP1B/HSP90AB1/RIPK3/TNFAIP3/RNF31/GLUL/TICAM2/TICAM1/BIRC3/TLR4/CAMK2G	1.98166823460585
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/645	122/9376	1.66811538950311	ADIPOR2/SCD/PPP2CA/PCK2/EEF2K/PIK3R2/PRKAG1/PPP2R3B/PIK3R3/SREBF1/ACACA/PFKFB2/ELAVL1/CPT1A	2.01883183566709
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/645	122/9376	1.66811538950311	CDC42/TNF/NFKBIA/NFKBIB/JUN/PPP2CA/NFKBIE/HRAS/PIK3R2/PPP2R3B/PTPRC/PIK3R3/MAPK3/IKBKB	2.01883183566709
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/645	68/9376	1.92393980848153	HRAS/PIK3R2/SPI1/BCL2A1/PIM1/PIK3R3/ITGAM/MAPK3/IKBKB	2.0782770882146
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	18/645	170/9376	1.53915184678523	CDC42/ACTN4/PRKACA/JUN/PPP2CA/ARPC1B/ARHGAP17/SCRIB/CLDN7/F11R/PRKAG1/TUBA1C/TJP2/CLDN23/RAPGEF6/ACTN1/CTTN/TUBA1B	1.92811784443523
NA	NA	hsa03272	Virion - Hepatitis viruses	7/645	48/9376	2.11989664082687	CHMP4A/CHMP1B/LAMP1/CLDN7/TGOLN2/HSPG2/CLDN23	2.11415971597438
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/645	20/9376	2.90728682170543	CYP51A1/LSS/MSMO1/NSDHL	2.32070212926334
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/645	243/9376	1.43569719590391	HSPA1A/HSPA1B/DDX39B/CWC25/FUS/PRPF8/HNRNPU/PUF60/PRPF31/DHX16/SRSF1/HSPA6/LSM2/SRSF2/RBM8A/RBM25/PRPF3/SRSF6/TRA2B/SF3A2/DDX23/SRSF7/SRSF8/RBM22	1.87031464396129
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/645	49/9376	2.0766334440753	GALNT4/COLGALT1/C1GALT1C1/POGLUT1/LFNG/RFNG/GALNT6	2.05365940991219
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/645	60/9376	1.93819121447028	PLCG2/CDC42/VEGFA/HRAS/PIK3R2/PIK3R3/MAPK3/PTGS2	1.9814620021316
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/645	71/9376	1.84264657713724	HRAS/PIK3R2/SOCS3/GALT/PIK3R3/SOCS7/MAPK3/TNFRSF11A/IRF1	1.93709066414118
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/645	93/9376	1.71936317412687	FN1/NFKBIA/COL4A1/PIK3R2/RXRB/PIK3R3/BIRC3/CDKN1A/CDKN2B/PTGS2/IKBKB	1.89486817610401
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	13/645	117/9376	1.6151593453919	INO80D/CHD4/TFPT/SMARCB1/SRCAP/INO80B/BRD9/KAT5/SMARCE1/PHF10/MCRS1/BAZ2A/ACTR8	1.81983501257663
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/645	250/9376	1.3954976744186	HLA-E/HLA-A/HSPA1A/HLA-C/HLA-F/HSPA1B/CDC42/HLA-B/VPS28/CHMP4A/HLA-G/RUFY1/ARPC1B/CHMP1B/AP2A2/HSPA6/HRAS/ACAP1/WWP1/RAB35/ASAP3/IL2RA/RAB5B/ITCH	1.72269029732039
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/645	201/9376	1.4464113540823	FUS/ID2/CEBPB/NUPR1/FLT1/TAF15/SPI1/MMP9/BCL2A1/IL6/RXRB/CXCL8/SP1/ITGAM/BIRC3/LDB1/EWSR1/CDKN1A/NFKBIZ/KMT2A	1.73885642998536
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	14/645	130/9376	1.56546213476446	PRKACA/GNG10/ATF6B/NFKBIA/VEGFA/JUN/ATF4/COL4A1/HRAS/PIK3R2/MMP9/PIK3R3/MAPK3/GNAS	1.76454103075573
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/645	107/9376	1.6302542925451	LDHA/PRKACA/PCK2/ATF4/PKM/PRKAG1/CALML4/ACACA/PHKG2/CPT1A/CAMK2G/GNAS	1.78207000916945
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/645	86/9376	1.69028303587525	PLCG2/JUN/EREG/HRAS/PIK3R2/AREG/PIK3R3/CDKN1A/MAPK3/CAMK2G	1.74784159524296
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/645	76/9376	1.72141982864137	PLCG2/PDGFB/HRAS/PIK3R2/CALML4/PIK3R3/CDKN1A/MAPK3/CAMK2G	1.7162750863141
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/645	99/9376	1.6151593453919	PRKACA/JUN/HRAS/PIK3R2/MMP9/JAG1/PIK3R3/SP1/CDKN1A/MAPK3/GNAS	1.67237992816736
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/645	44/9376	1.98224101479915	TAF9/GTF2H1/TAF15/CDK7/GTF2H2/GTF2H4	1.77496804712323
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/645	89/9376	1.6333072032053	TUBB/PRKACA/TUBB4B/PDGFB/HRAS/TUBA1C/MAPK3/TUBB3/GNAS/TUBA1B	1.6315681155596
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/645	78/9376	1.67728085867621	LSM2/PARN/CNOT3/HSPD1/EXOSC4/EXOSC10/HSPA9/ENO2/BTG3	1.63250617834343
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	27/645	300/9376	1.30827906976744	HSPA1A/HSPA1B/CDC42/TNF/DUSP2/PRKACA/RPS6KA1/VEGFA/JUN/ATF4/EREG/DUSP8/FLNA/DAXX/HSPA6/FLT1/PDGFB/HRAS/NFKB2/DUSP16/AREG/ANGPT2/CACNA2D4/MAPK3/MKNK1/NR4A1/IKBKB	1.47499627994988
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/645	16/9376	2.72558139534884	MIF/IL4I1/GOT2	1.87754786769702
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/645	16/9376	2.72558139534884	HEXA/HEXB/GBGT1	1.87754786769702
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/645	80/9376	1.6353488372093	PLCG2/VEGFA/PDGFB/HRAS/PIK3R2/EIF4E/IL6/PIK3R3/MAPK3	1.55111028237423
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/645	69/9376	1.68538366475677	PLCG2/TNF/ALOX5/INPP5D/HRAS/PIK3R2/PIK3R3/MAPK3	1.55305536849971
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/645	69/9376	1.68538366475677	FOSB/PRKACA/ATF6B/JUN/ATF4/CALML4/CAMK2G/GNAS	1.55305536849971
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/645	93/9376	1.56305743102442	CDC42/PRKACA/JUN/MMP14/ATF4/HRAS/CALML4/MAPK3/CAMK2G/GNAS	1.48314460030852
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/645	105/9376	1.52286452565522	SQSTM1/GABARAP/CSNK2B/JUN/ATF4/HRAS/RABGEF1/ATG9A/SP1/VCP/RAB5B	1.46438084033603
NA	NA	hsa04518	Integrin signaling	15/645	154/9376	1.41588643914225	FN1/CDC42/ACTN4/ITGB2/VEGFA/FLNA/COL4A1/FLT1/PDGFB/PIK3R2/ITGA5/ITGAX/PIK3R3/ACTN1/ITGAM	1.41434728914486
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/645	204/9376	1.35388356893145	PLCG2/FN1/CDC42/TNF/PRKACA/CTSL/VEGFA/FLNA/HRAS/PIK3R2/MMP9/HSPG2/ITGA5/PIK3R3/CTTN/CDKN1A/MAPK3/TLR4/CAMK2G	1.38891913310861
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/645	168/9376	1.3844222960502	IFNGR2/IL10RB/IRF9/MCL1/PDGFB/IL27RA/HRAS/CSH1/PIK3R2/SOCS3/IL6/PIM1/PIK3R3/SOCS7/CDKN1A/IL2RA	1.36651390512418
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	9/645	83/9376	1.5762398430933	CSNK2B/SKP1/RING1/PHF1/RYBP/EPOP/EED/MBD6/USP7	1.43317050775288
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/645	38/9376	1.91268869849041	HEXA/GALT/HEXB/HK3/GNPNAT1	1.53221968563436
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/645	49/9376	1.77997152349312	FOSB/PRKACA/ATF6B/JUN/ATF4/GNAS	1.48778199999252
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/645	72/9376	1.6151593453919	IRF7/TNF/NFKBIA/NFKBIB/ISG15/CXCL8/DDX3X/IKBKB	1.42413947594372
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/645	62/9376	1.64121030257564	MAML1/PSEN2/DTX2/JAG1/LFNG/RFNG/ITCH	1.37677103659026
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/645	122/9376	1.42981319100267	PLCG2/PRKACA/ATF6B/ATF4/HRAS/CSH1/PIK3R2/SOCS3/SSTR2/PIK3R3/MAPK3/GNAS	1.29875851839184
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/645	110/9376	1.45364341085271	TNF/SMAD7/ID3/ID2/PPP2CA/SKP1/ID1/INHBA/SP1/CDKN2B/MAPK3	1.3007633840341
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/645	98/9376	1.48330960291093	PLCG2/CDC42/INPP5D/ARPC1B/FCGR3A/PIK3R2/PTPRC/PIK3R3/ASAP3/MAPK3	1.30720824793648
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/645	75/9376	1.55055297157623	PKM/SHMT1/GLUL/PYCR2/ACY1/GOT2/PRPS1/ENO2	1.30106328615979
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/645	87/9376	1.5037690457097	JUN/EREG/RALGDS/HRAS/PIK3R2/AREG/PIK3R3/CDKN1A/MAPK3	1.28303978944449
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/645	41/9376	1.77273586689355	POLD4/RAD50/SSBP1/TOP3A/POLD2	1.34771896359499
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/645	76/9376	1.53015095879233	SCD/PCK2/ANGPTL4/PLTP/RXRB/SLC27A1/NR1H3/CPT1A	1.26124185451676
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/645	65/9376	1.56546213476446	PRKACA/ATF6B/ATF4/CYP11A1/SP1/NR4A1/GNAS	1.24335614423269
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/645	77/9376	1.5102788684184	CDC42/VEGFA/RALGDS/PIK3R2/PIK3R3/CDKN1A/MAPK3/IKBKB	1.22199189079295
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	18/645	203/9376	1.2889448963226	FN1/CDC42/ACTN4/ZYX/VEGFA/JUN/FLNA/COL4A1/FLT1/PDGFB/HRAS/PIK3R2/ITGA5/PIK3R3/ARHGAP35/ACTN1/BIRC3/MAPK3	1.13120378987035
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/645	55/9376	1.58579281183932	NEU1/PSAP/SGPP1/HEXA/GM2A/HEXB	1.18420701764255
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/645	67/9376	1.51873192178642	PRKACA/RPS6KA1/ATF4/HRAS/CALML4/MAPK3/CAMK2G	1.15814346804708
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/645	44/9376	1.65186751233263	PRKACA/NSF/DYNC1H1/RAB5B/GNAS	1.17796344065791
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/645	56/9376	1.55747508305648	MGAT4B/SRD5A3/KRTCAP2/ALG9/MGAT1/MOGS	1.13722138971529
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/645	45/9376	1.6151593453919	TAP1/TAP2/ABCC1/DEFB1/ABCD1	1.12425101854141
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	14/645	158/9376	1.28803846531253	TNF/RPS6KA1/SESN2/HRAS/PIK3R2/EIF4E/PIK3R3/FNIP1/MIOS/SLC7A5/MAPK3/DDIT4/MLST8/IKBKB	0.992416968495942
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/645	34/9376	1.71016871865025	SKP1/BHLHE40/PRKAG1/CSNK1E	1.12749485074084
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	20/645	238/9376	1.22154908475018	PLCG2/CDC42/PRKACA/GNG10/VEGFA/RASA3/RALGDS/FLT1/PDGFB/HRAS/PIK3R2/RGL2/CALML4/ANGPT2/ETS2/PIK3R3/SYNGAP1/MAPK3/RAB5B/IKBKB	0.94094960291089
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	18/645	212/9376	1.23422553751645	CDC42/ITGB2/VEGFA/RALGDS/FLT1/PDGFB/HRAS/PIK3R2/CTNND1/CALML4/P2RY1/ID1/ANGPT2/RAPGEF6/PIK3R3/ITGAM/MAPK3/GNAS	0.93754718867827
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/645	23/9376	1.89605662285137	GLUL/ACY1/GOT2	1.16938469738123
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/645	23/9376	1.89605662285137	POLD4/SSBP1/POLD2	1.16938469738123
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/645	108/9376	1.34596612115992	DDX39B/RBM8A/XPO6/POM121/IPO9/GLE1/NUP43/RANGAP1/UPF2/AHCTF1	0.982847051292104
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/645	83/9376	1.4011020827496	ECH1/SOD2/DHRS4/MPV17L/AMACR/DECR2/ABCD1/PEX10	0.997584048525968
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/645	122/9376	1.31066209175245	PLCG2/PRKACA/MED17/HRAS/PIK3R2/DIO2/RXRB/PIK3R3/MAPK3/PFKFB2/MED16	0.938721859754208
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/645	98/9376	1.33497864261984	PLCG2/INPP5D/ITPK1/PIP4K2B/PIK3R2/CALML4/PIK3R3/IPPK/PI4K2A	0.906017264870934
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	9/645	98/9376	1.33497864261984	PRKACA/ATF6B/ATF4/NR4A2/CALML4/CYP11A1/NR4A1/CAMK2G/GNAS	0.906017264870934
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/645	36/9376	1.6151593453919	POLD4/SSBP1/MCM6/POLD2	1.0050760858822
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/645	73/9376	1.3939046405437	CHMP4A/NELFE/SMARCB1/SUPT4H1/MX1/SAMHD1/CPSF7	0.918278715806148
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/645	73/9376	1.3939046405437	PLCG2/HRAS/PIK3R2/RXRB/PIK3R3/CDKN1A/MAPK3	0.918278715806148
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/645	217/9376	1.20578716107598	PRKACA/ATF6B/RPS6KA1/VEGFA/HSP90AA1/JUN/ATF4/AHR/HRAS/PIK3R2/HSP90AB1/KLF4/RXRB/HSP90B1/JAG1/PIK3R3/MAPK3/GNAS	0.833599824938234
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/645	99/9376	1.3214940098661	JUN/RALGDS/PDGFB/HRAS/PIK3R2/CHKB/PIK3R3/SP1/MAPK3	0.874017656000298
NA	NA	hsa04517	IgSF CAM signaling	24/645	299/9376	1.16680407560084	PLCG2/TUBB/CDC42/ACTN4/INPP5D/ITGB2/PPFIA1/ARPC1B/TUBB4B/NRP2/PIK3R2/F11R/TUBA1C/TJP2/ITGA5/RAPGEF6/ITGAX/PIK3R3/ACTN1/ITGAM/PTPRF/MAPK3/TUBB3/TUBA1B	0.796717920088962
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/645	37/9376	1.57150639011104	GLUL/IL4I1/GOT2/ADSL	0.946684499820299
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/645	37/9376	1.57150639011104	TNF/HBA2/HBA1/IL6	0.946684499820299
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/645	37/9376	1.57150639011104	HRAS/RXRB/CDKN1A/MAPK3	0.946684499820299
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/645	75/9376	1.3567338501292	CANX/PRKACA/ATF6B/ATF4/HSPA5/HSP90B1/GNAS	0.843031169198346
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/645	115/9376	1.26403774856758	PRKACA/ATF6B/MMP14/ATF4/NR4A2/RXRB/SP1/CDKN1A/MAPK3/GNAS	0.774318259013507
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/645	155/9376	1.21918479619905	PRKACA/ATF6B/ATF4/AHR/CYP11A1/SP1/CDKN1A/CDKN2B/MAPK3/NR4A1/KMT2A/CAMK2G/GNAS	0.747860792494938
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/645	51/9376	1.42514059887521	PLCG2/ATP6V0C/PRKACA/TJP2/GNAS	0.827421400223763
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/645	77/9376	1.3214940098661	NFKBIA/HRAS/PIK3R2/PIK3R3/CDKN1A/MAPK3/IKBKB	0.769898769691475
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/645	157/9376	1.20365377968696	YWHAE/SMAD7/ITGB2/ID2/PPP2CA/SCRIB/SERPINE1/AREG/ID1/LIMD1/CSNK1E/BIRC3/DLG5	0.699413313345222
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/645	52/9376	1.39773404889684	ALOX5/PRKACA/CYP11A1/PTGS2/GNAS	0.781676061564599
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/645	78/9376	1.30455177897038	FN1/CDC42/ARPC1B/PIK3R2/ITGA5/PIK3R3/CTTN	0.734086390343899
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/645	93/9376	1.25044594481954	CDC42/ACTN4/CSNK2B/CTNND1/SNAI1/ACTN1/PTPRF/MAPK3	0.65969744871754
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	23/645	298/9376	1.12193954528901	CCL3/CCL4/TNFRSF14/TNF/TNFSF13/IFNGR2/IL10RB/CCL20/CCL5/IL27RA/CCL18/CCL2/CSH1/CXCL3/CXCL1/IL6/LTB/CXCL8/ACKR3/CCL8/INHBA/IL2RA/TNFRSF11A	0.581421537798555
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/645	149/9376	1.17071952551896	PLCG2/RALGDS/PDGFB/HRAS/PIK3R2/AGPAT1/AGPAT5/CXCL8/PIK3R3/MAPK3/LPAR6/GNAS	0.570925670171212
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/645	17/9376	1.71016871865025	NRP2/LAMP1	0.796534841438891
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/645	30/9376	1.45364341085271	B3GALT4/PIGW/PIGU	0.676387927626274
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/645	43/9376	1.3522264287002	DGAT1/AGPAT1/GOT2/SLC27A1	0.629185978394797
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/645	18/9376	1.6151593453919	ACACA/ACSF3	0.710012279240957
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/645	57/9376	1.27512579899361	SCD/ACACA/ACSF3/CPT1A/ACADVL	0.566262223823152
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/645	125/9376	1.16291472868217	TNF/PPP2CA/SGPP1/CTSD/HRAS/PIK3R2/ABCC1/PPP2R3B/PIK3R3/MAPK3	0.498373012723415
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/645	31/9376	1.40675168792198	BAG6/HSPA5/SRP68	0.616529780426939
NA	NA	hsa04981	Folate transport and metabolism	3/645	31/9376	1.40675168792198	ABCC1/SHMT1/FPGS	0.616529780426939
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/645	154/9376	1.1327091513138	PRKACA/JUN/EEF2K/HRAS/PRKAG1/CALML4/CDKN1A/CACNA2D4/MAPK3/PTGS2/CAMK2G/GNAS	0.451317500980576
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/645	99/9376	1.1746613421032	PLCG2/PRKACA/PIK3R2/CALML4/PIK3R3/PTGER4/CAMK2G/GNAS	0.474836519916768
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/645	32/9376	1.36279069767442	GALT/GAA/HK3	0.558725147014103
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/645	32/9376	1.36279069767442	LDHA/BCKDHA/ACACA	0.558725147014103
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/645	59/9376	1.23190119563789	PRKACA/PIK3R2/PIK3R3/PTGS2/GNAS	0.485651178855244
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/645	59/9376	1.23190119563789	HRAS/PIK3R2/PIK3R3/CDKN1A/MAPK3	0.485651178855244
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/645	142/9376	1.12606179713943	SKP1/HERC3/HERC2/SOCS3/WWP1/BIRC3/UBE2W/MGRN1/ITCH/PPIL2/UBE3B	0.411401842733051
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/645	73/9376	1.19477540618031	PDGFB/HRAS/PIK3R2/PIK3R3/CDKN1A/MAPK3	0.454064490357372
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/645	33/9376	1.3214940098661	BCKDHA/ACY1/GOT2	0.502828844052308
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	12/645	158/9376	1.10403297026788	YWHAE/CDKN1C/PPP2CA/SKP1/MAD1L1/TFDP2/CDK7/ESCO1/CDKN1A/CDKN2B/MCM6/DDX11	0.358438533078762
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/645	47/9376	1.23714332838529	LDHA/PCK2/PKM/ACACA	0.442971509681888
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/645	75/9376	1.16291472868217	PIK3R2/ATP7A/PIK3R3/BIRC3/CDKN1A/MAPK3	0.384999052236899
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/645	89/9376	1.14331504224371	GABARAP/PRKACA/GNG10/NSF/SLC38A2/GLUL/GABBR1	0.369217738597409
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/645	34/9376	1.28262653898769	POLR2J3/POLR2A/POLR3E	0.44871022761601
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/645	48/9376	1.21136950904393	PIK3R2/SLC37A4/PIK3R3/HK3	0.399026914551694
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	17/645	232/9376	1.06516974071104	FN1/CDC42/ACTN4/CYFIP1/ITGB2/ARPC1B/PIP4K2B/PDGFB/HRAS/PIK3R2/ITGA5/ITGAX/PIK3R3/ARHGAP35/ACTN1/ITGAM/MAPK3	0.273184074541238
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/645	35/9376	1.24598006644518	TIGAR/HK3/PFKFB2	0.396251347437395
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/645	78/9376	1.11818723911747	PLCG2/INPP5D/ITPK1/PIP4K2B/IPPK/PI4K2A	0.284876496344134
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/645	22/9376	1.3214940098661	AOC1/CNDP2	0.410316559497391
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/645	50/9376	1.16291472868217	AOC1/PYCR2/CNDP2/GOT2	0.313928791003292
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/645	36/9376	1.21136950904393	GALNT4/C1GALT1C1/GALNT6	0.34534538151147
Genetic Information Processing	Translation	hsa03010	Ribosome	16/645	222/9376	1.04767092674069	RPS18/RPS9/RPS17/RPL7A/RPS25/RPL36A/RPL17/MRPS18B/MRPL38/MRPS24/MRPS12/MRPL23/MRPL45/MRPS5/MRPL46/MRPL30	0.195370113787102
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/645	65/9376	1.11818723911747	HRAS/PIK3R2/PIK3R3/GABBR1/MAPK3	0.259873864034799
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/645	37/9376	1.17862979258328	MIF/IL4I1/GOT2	0.295895301908786
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/645	37/9376	1.17862979258328	GALT/HK3/GNPNAT1	0.295895301908786
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/645	195/9376	1.04364142317631	PLCG2/ITGB2/GSDMD/FCGR3A/PPIF/PIK3R2/AGER/PIK3R3/CLCN3/ITGAM/MAPK3/TLR4/C5AR1/AZU1	0.167380445012055
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/645	23/9376	1.26403774856758	ANPEP/CTSA	0.344578338948489
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/645	138/9376	1.05336479047298	YWHAE/PRKACA/RPS6KA1/PPP2CA/SKP1/MAD1L1/CALML4/REC8/MAPK3/CAMK2G	0.171648050092696
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/645	52/9376	1.11818723911747	APOC2/LRP1/ANGPTL4/PLTP	0.232276155025642
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/645	110/9376	1.05719520789288	PRKACA/RPS6KA1/HSP90AA1/MAD1L1/PIK3R2/HSP90AB1/PIK3R3/MAPK3	0.163999807755247
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/645	38/9376	1.14761321909425	PIK3R2/PIK3R3/MAPK3	0.247812732348017
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/645	38/9376	1.14761321909425	TAP1/TAP2/PTPRC	0.247812732348017
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/645	67/9376	1.08480851556173	LDHA/PCK2/PKM/HK3/ENO2	0.189347183405118
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/645	54/9376	1.07677289692794	LDHA/IL4I1/ADI1/GOT2	0.153774300620147
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/645	69/9376	1.05336479047298	CTSB/PRKACA/CALML4/PTGER4/GNAS	0.120922745309865
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/645	85/9376	1.02610123119015	NME2/TYMP/AK6/GMPR2/IMPDH2/ADSL	0.065701113138133
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/645	144/9376	1.00947459086994	ID3/ID2/HRAS/PIK3R2/KLF4/ID1/PIK3R3/INHBA/MAPK3/DLX5	0.0311406243010591
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/645	144/9376	1.00947459086994	PSMB3/PSMA6/PSMA2/PSMC4/PPIF/PIK3R2/PIK3R3/KAT5/SP1/OMA1	0.0311406243010591
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/645	115/9376	1.01123019885406	PRKACA/GNG10/ATF4/HRAS/PIK3R2/PIK3R3/MAPK3/CAMK2G	0.0329337303935795
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/645	56/9376	1.03831672203765	PRKACA/CSNK1E/MGRN1/HHAT	0.0781642035839274
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/645	87/9376	1.0025126971398	MT-CO3/MT-CO1/MT-CO2/MT-CYB/CACNA2D4/COX4I2	0.00639954049707006
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/645	133/9376	0.983668473509355	PRKACA/GNG10/ATF6B/PPP2CA/ATF4/CALML4/PPP2R3B/CAMK2G/GNAS	-0.0515560486765872
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/645	104/9376	0.978413834227788	LPCAT1/PLD3/AGPAT1/CRLS1/MBOAT7/CHKB/AGPAT5	-0.0601643137663283
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/645	194/9376	0.974090945416767	TUBB/DYNLRB1/TUBB4B/DYNC1H1/MYO19/TUBA1C/TNNI2/MYO15B/KIFC1/KIF27/TUBB3/KIF3B/TUBA1B	-0.0991099570892355
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/645	28/9376	1.03831672203765	ATP6V0C/SLC12A7	0.0551876007412676
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/645	75/9376	0.969095607235142	CD82/SESN2/SERPINE1/CDKN1A/MDM4	-0.0730330647245483
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/645	60/9376	0.969095607235142	PPP2CA/HRAS/MAPK3/GNAS	-0.0652701485774315
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/645	29/9376	1.0025126971398	LIMD1/CSNK1E	0.00368329517761588
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/645	13/9376	1.11818723911747	RAD50	0.115895948309072
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/645	76/9376	0.956344349245206	PRKACA/SSTR2/CALML4/CAMK2G/GNAS	-0.103857840875245
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/645	61/9376	0.953208794001779	HMOX2/HMOX1/SLC39A4/ATP7A	-0.0996486061123178
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/645	30/9376	0.969095607235142	PCK2/ACLY	-0.0460788312509127
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/645	154/9376	0.943924292761502	PRKACA/ATF6B/PPP2CA/ATF4/CALML4/PPP2R3B/CACNA2D4/MAPK3/CAMK2G/GNAS	-0.190702357795616
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/645	170/9376	0.940592795257638	PLCG2/SMARCB1/HRAS/PIK3R2/HMOX1/PIK3R3/SMARCE1/CDKN1A/MAPK3/PHF10/TXNRD2	-0.212452377256522
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/645	63/9376	0.922948197366802	EHMT2/COLGALT1/PLOD2/KMT2A	-0.166779158481799
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/645	63/9376	0.922948197366802	ALOX5/LTC4S/PRXL2B/PTGS2	-0.166779158481799
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/645	31/9376	0.937834458614654	SHMT1/GLUL	-0.0942267941805836
Organismal Systems	Immune system	hsa04611	Platelet activation	8/645	126/9376	0.922948197366802	PLCG2/PRKACA/PIK3R2/P2RY1/PIK3R3/ARHGAP35/MAPK3/GNAS	-0.236663188375786
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/645	48/9376	0.908527131782946	BCKDHA/IL4I1/ACSF3	-0.172684019255868
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/645	65/9376	0.894549791293977	DGAT1/ABHD16A/AGPAT1/AGPAT5	-0.231867276064146
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/645	97/9376	0.8991608726924	PRKACA/GNG10/CALML4/MAPK3/CAMK2G/GNAS	-0.271330028026762
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/645	99/9376	0.880996006577402	TNF/LMNA/PRKAG1/IL6/ITGA5/CACNA2D4	-0.323525752250293
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/645	115/9376	0.884826423997304	ALOX5/PRKACA/GNG10/HRAS/MAPK3/PTGS2/GNAS	-0.337758533916384
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/645	148/9376	0.883972344437461	JUN/HRAS/NFKB2/PIK3R2/JAG1/PIK3R3/SP1/CDKN1A/MAPK3	-0.386698140072939
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/645	17/9376	0.855084359325125	AMACR	-0.162539342885116
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/645	17/9376	0.855084359325125	TXNRD2	-0.162539342885116
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/645	17/9376	0.855084359325125	GLUL	-0.162539342885116
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/645	101/9376	0.863550541100622	PRKACA/HRAS/CALML4/MAPK3/CAMK2G/GNAS	-0.374721875392867
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/645	86/9376	0.845141517937624	PRKACA/ATF6B/ATF4/CAMK2G/GNAS	-0.392111760332645
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/645	53/9376	0.82281702501097	PRKACA/AP2A2/GNAS	-0.351573055584113
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/645	36/9376	0.807579672695952	GAA/HK3	-0.31438532285926
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	20/645	323/9376	0.900088799289606	PLCG2/VEGFA/MCL1/PDGFB/SOX4/HRAS/PIK3R2/HMOX1/ABCC1/MMP9/ST14/ITGA5/PIM1/PIK3R3/CDKN1A/MAPK3/MDM4/DDIT4/PTGS2/IKBKB	-0.496652562579968
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/645	105/9376	0.830653377630122	TNF/PRKACA/LMNA/ITGA5/CACNA2D4/GNAS	-0.474287194877692
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/645	19/9376	0.765075479396165	BCKDHA	-0.278593087502521
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/645	38/9376	0.765075479396165	NAPRT/SIRT2	-0.394390744295157
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/645	140/9376	0.830653377630122	PRKACA/GNG10/SERPINE1/HRAS/PRKAG1/CALML4/JAG1/MAPK3	-0.548696381504256
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/645	42/9376	0.692211148025101	AOC1/IL4I1	-0.543346825559419
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/645	42/9376	0.692211148025101	HMOX1/PRNP	-0.543346825559419
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/645	43/9376	0.676113214350099	CPT1A/ACADVL	-0.578562559516886
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/645	23/9376	0.632018874283788	B3GALNT2	-0.480228019484249
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/645	23/9376	0.632018874283788	PCK2	-0.480228019484249
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/645	44/9376	0.660747004933051	POLD4/POLD2	-0.613050378738072
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/645	116/9376	0.751884522854852	PKM/SHMT1/HK3/GOT2/PRPS1/ENO2	-0.730820731323026
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/645	116/9376	0.751884522854852	PRKACA/GNG10/SLC38A2/GLUL/MAPK3/GNAS	-0.730820731323026
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/645	184/9376	0.790023592854735	PLCG2/CDC42/HRAS/PIK3R2/EPHB6/SEMA7A/PIK3R3/SEMA4C/MAPK3/CAMK2G	-0.781822033054278
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/645	82/9376	0.709094346757421	NME2/TYMP/IMPDH2/CES1	-0.719103255052346
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/645	46/9376	0.632018874283788	HMOX2/HMOX1	-0.679981565520913
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	8/645	154/9376	0.755139434209202	NME2/NAPRT/AK6/SHMT1/FPGS/PDXP/RDH13/ADSL	-0.832722216571808
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/645	26/9376	0.559093619558736	ABCC1	-0.611872244829661
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/645	27/9376	0.538386448463968	SCD	-0.652846910867506
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/645	68/9376	0.641313269493844	DGAT1/DHRS4/RDH13	-0.806817075110848
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/645	28/9376	0.519158361018826	GCNT2	-0.692556538782035
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/645	28/9376	0.519158361018826	FPGS	-0.692556538782035
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/645	89/9376	0.653322881282118	FN1/COL4A1/HSPG2/ITGA5	-0.893132638364779
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/645	29/9376	0.501256348569901	CALML4	-0.7310949087655
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/645	51/9376	0.570056239550084	LPCAT1/PLD3	-0.836769457516245
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/645	91/9376	0.638964136638555	PRKACA/GNG10/GABBR1/GNAS	-0.940618655721785
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/645	128/9376	0.681395348837209	NME2/AK6/GMPR2/IMPDH2/ADSL/PRPS1	-0.986430943545622
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/645	31/9376	0.468917229307327	PRPS1	-0.804983368788106
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/645	31/9376	0.468917229307327	CNDP2	-0.804983368788106
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/645	93/9376	0.625222972409769	PRKACA/CALML4/PRH1/GNAS	-0.987196854464423
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/645	32/9376	0.454263565891473	BIRC3	-0.840475434824634
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/645	150/9376	0.6783669250646	HRAS/PIK3R2/RXRB/PIK3R3/CDKN1A/CDKN2B/MAPK3	-1.0792774634095
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/645	79/9376	0.552016485133942	ATP6V0C/NSF/AP2A2	-1.08677005790867
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/645	226/9376	0.70752555395486	PRKACA/NFKBIA/JUN/PIK3R2/SSTR2/CALML4/PIK3R3/GABBR1/MAPK3/CAMK2G/GNAS	-1.20966496076618
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/645	191/9376	0.684962863752587	FOSB/PRKACA/GNG10/ATF6B/ATF4/HRAS/CALML4/MAPK3/GNAS	-1.19556269598064
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/645	59/9376	0.492760478255157	NME2/TYMP	-1.06226908843544
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/645	59/9376	0.492760478255157	TXNDC12/ANPEP	-1.06226908843544
NA	NA	hsa04382	Cornified envelope formation	10/645	217/9376	0.669881756153324	PPP2CA/PLEC/COL4A1/CLDN7/ST14/TCHH/CLDN23/PPP2R3B/KRT7/SLC27A1	-1.33723847902201
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/645	39/9376	0.372729079705824	SHMT1	-1.06688419146466
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/645	86/9376	0.507084910762574	PRKACA/P2RY1/GABBR1	-1.24809310256289
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/645	86/9376	0.507084910762574	LMNA/ITGA5/CACNA2D4	-1.24809310256289
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/645	183/9376	0.635472529334519	CSNK2B/FBL/AK6/RMRP/RBM28/GTPBP4/MDN1/HEATR1	-1.35350753670495
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/645	41/9376	0.354547173378711	SHMT1	-1.12572620453158
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/645	66/9376	0.440498003288701	SRD5A3/CYP11A1	-1.23974472600076
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/645	134/9376	0.542404257780863	PRKACA/ADM/CALML4/MAPK3/GNAS	-1.45005639622043
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/645	233/9376	0.623881292211465	FN1/ZYX/LMNA/PLEC/COL4A1/FBLN1/TNNI2/HSPG2/ITGA5/ENO2	-1.58012715776256
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/645	178/9376	0.571657521121854	NOTUM/PRKACA/CSNK2B/JUN/SKP1/CSNK1E/CAMK2G	-1.5681512393211
NA	NA	hsa04081	Hormone signaling	9/645	219/9376	0.597387703090156	PRKACA/ADIPOR2/GNG10/CSH1/PIK3R2/DIO2/SSTR2/PIK3R3/GNAS	-1.63857372696049
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/645	54/9376	0.269193224231984	TOP3A	-1.46378872400345
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/645	254/9376	0.572300555453824	PLCG2/PRKACA/VEGFA/FLT1/PDGFB/PPIF/CALML4/PHKG2/CAMK2G/GNAS	-1.87820940970627
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/645	90/9376	0.323031869078381	PRKACA/GNAS	-1.75391539730336
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/645	63/9376	0.2307370493417	CDKN1A	-1.66507496486188
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/645	166/9376	0.437844400859251	ATF6B/ATF4/PPIF/CALML4/MAPK3	-1.98616018179198
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/645	70/9376	0.20766334440753	PTGS2	-1.80846765351654
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/645	103/9376	0.282260856476255	SLC38A2/COL4A1	-1.99071283238481
NA	NA	hsa04519	Cadherin signaling	16/645	404/9376	0.575700360733748	YWHAE/CDC42/ACTN4/CYFIP1/NFKBIA/ARPC1B/HRAS/CTNND1/PSEN2/LHFPL2/LIMD1/ARHGAP35/ACTN1/KRT7/MAPK3/IKBKB	-2.36947545373497
NA	NA	hsa04082	Neuroactive ligand signaling	5/645	199/9376	0.365237037902692	PRKACA/GNG10/P2RY1/GABBR1/GNAS	-2.45992152013203
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/645	102/9376	0.142514059887521	GNAS	-2.36661192926347
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/645	370/9376	0.432164257280536	ADM/CSH1/SSTR2/CHRNB1/P2RY1/LTB4R/GABBR1/LPAR6/C5AR1/PGRMC2/PTGER4	-3.02894312142341
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/645	449/9376	0.129500526579306	PRKACA/CALML4/OR4D9/CAMK2G	-5.13774348566773