ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0042605 peptide antigen binding 23/1192 45/18639 0.511111111111111 7.99211409395973 2.94931536038498e-16 3.27668936538771e-13 GO:0023023 MHC protein complex binding 19/1192 37/18639 0.513513513513513 8.02967984763287 1.04215811755912e-13 5.78918834304093e-11 GO:0023026 MHC class II protein complex binding 16/1192 27/18639 0.592592592592593 9.2662192393736 4.73476886958545e-13 1.75344273803648e-10 GO:0042277 peptide binding 47/1192 249/18639 0.188755020080321 2.9515141101318 1.68977771870353e-11 4.69335761369904e-09 GO:0032396 inhibitory MHC class I receptor activity 9/1192 13/18639 0.692307692307692 10.825438822922 9.82971087592643e-09 2.18416175663085e-06 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 18/1192 68/18639 0.264705882352941 4.13913837347019 1.68066429033952e-07 2.55020003920719e-05 GO:0035198 miRNA binding 14/1192 42/18639 0.333333333333333 5.21224832214765 1.72414832480607e-07 2.55020003920719e-05 GO:0140104 molecular carrier activity 39/1192 249/18639 0.156626506024096 2.44912872968384 1.83632766099528e-07 2.55020003920719e-05 GO:0140597 protein carrier chaperone 32/1192 188/18639 0.170212765957447 2.66157361130944 3.43719577569002e-07 4.24302722976846e-05 GO:0032395 MHC class II receptor activity 7/1192 10/18639 0.7 10.9457214765101 4.34958781900104e-07 4.83239206691015e-05 GO:0032393 MHC class I receptor activity 9/1192 18/18639 0.5 7.81837248322148 4.98563471916513e-07 5.03549106635678e-05 GO:0008135 translation factor activity, RNA binding 19/1192 83/18639 0.228915662650602 3.57949583569176 8.95606508601962e-07 8.29182359213983e-05 GO:0180051 translation factor activity 19/1192 84/18639 0.226190476190476 3.53688279002876 1.08876428682969e-06 9.30474709744455e-05 GO:0051082 unfolded protein binding 23/1192 121/18639 0.190082644628099 2.97227383659659 2.17870675295616e-06 0.000172895943038164 GO:0061980 regulatory RNA binding 15/1192 58/18639 0.258620689655172 4.04398576718352 2.45622089258503e-06 0.000181924094110798 GO:0140416 transcription regulator inhibitor activity 11/1192 33/18639 0.333333333333333 5.21224832214765 3.65427000430084e-06 0.00025374337342364 GO:0140662 ATP-dependent protein folding chaperone 12/1192 40/18639 0.3 4.69102348993289 4.6306255491763e-06 0.000302624999125581 GO:0008137 NADH dehydrogenase (ubiquinone) activity 12/1192 41/18639 0.292682926829268 4.57660828286135 6.16780607302901e-06 0.000380690697063068 GO:0003746 translation elongation factor activity 8/1192 18/18639 0.444444444444444 6.9496644295302 6.70855299022941e-06 0.000392273809060257 GO:0038024 cargo receptor activity 15/1192 65/18639 0.230769230769231 3.60847960764068 1.12184800022931e-05 0.000623186564127384 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 14/1192 58/18639 0.241379310344828 3.77438671603795 1.26173087426812e-05 0.000667515714910419 GO:0003954 NADH dehydrogenase activity 12/1192 44/18639 0.272727272727273 4.2645668090299 1.37737085047476e-05 0.000695572279489754 GO:0140713 histone chaperone activity 26/1192 164/18639 0.158536585365854 2.47899615321657 1.5786655811894e-05 0.000735317836895146 GO:0003823 antigen binding 27/1192 174/18639 0.155172413793103 2.42639146031011 1.62940774892524e-05 0.000735317836895146 GO:0044183 protein folding chaperone 16/1192 75/18639 0.213333333333333 3.3358389261745 1.67441929213137e-05 0.000735317836895146 GO:0042288 MHC class I protein binding 8/1192 20/18639 0.4 6.25469798657718 1.72081581991663e-05 0.000735317836895146 GO:0044389 ubiquitin-like protein ligase binding 41/1192 322/18639 0.127329192546584 1.99101411063404 1.96231284245533e-05 0.000807455395543657 GO:0140311 protein sequestering activity 10/1192 33/18639 0.303030303030303 4.73840756558877 2.62690525002592e-05 0.00104231847599243 GO:0005044 scavenger receptor activity 9/1192 27/18639 0.333333333333333 5.21224832214765 2.84195755765166e-05 0.00108876374019 GO:0031625 ubiquitin protein ligase binding 38/1192 302/18639 0.125827814569536 1.96753744610872 5.05852544542613e-05 0.00187334058995614 GO:0140375 immune receptor activity 24/1192 156/18639 0.153846153846154 2.40565307176045 5.43434264747063e-05 0.00194035860134979 GO:0022853 active monoatomic ion transmembrane transporter activity 20/1192 118/18639 0.169491525423729 2.65029575702423 5.5887916510525e-05 0.00194035860134979 GO:0003689 DNA clamp loader activity 24/1192 160/18639 0.15 2.34551174496644 8.20155077790277e-05 0.00270653160818083 GO:0000510 H3-H4 histone complex chaperone activity 23/1192 151/18639 0.152317880794702 2.38175585581581 9.01365162040421e-05 0.00270653160818083 GO:0140584 chromatin extrusion motor activity 23/1192 151/18639 0.152317880794702 2.38175585581581 9.01365162040421e-05 0.00270653160818083 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 23/1192 151/18639 0.152317880794702 2.38175585581581 9.01365162040421e-05 0.00270653160818083 GO:0140849 ATP-dependent H2AZ histone chaperone activity 23/1192 151/18639 0.152317880794702 2.38175585581581 9.01365162040421e-05 0.00270653160818083 GO:0015616 DNA translocase activity 23/1192 152/18639 0.151315789473684 2.36608640939597 9.99041869651794e-05 0.0028459885055978 GO:0140674 ATP-dependent histone chaperone activity 23/1192 152/18639 0.151315789473684 2.36608640939597 9.99041869651794e-05 0.0028459885055978 GO:0061775 cohesin loader activity 23/1192 153/18639 0.150326797385621 2.3506217923411 0.00011060267837107 0.00304181041717173 GO:0016887 ATP hydrolysis activity 47/1192 417/18639 0.112709832134293 1.76241490029453 0.000112254029796617 0.00304181041717173 GO:0015078 proton transmembrane transporter activity 26/1192 185/18639 0.140540540540541 2.19759658987847 0.000127792809084766 0.00338042406888512 GO:0009055 electron transfer activity 19/1192 116/18639 0.163793103448276 2.5611909858829 0.000136044746837691 0.00351501659852733 GO:0015399 primary active transmembrane transporter activity 24/1192 166/18639 0.144578313253012 2.26073421201585 0.000147231587661168 0.00368098297503209 GO:0140313 molecular sequestering activity 12/1192 55/18639 0.218181818181818 3.41165344722392 0.000149094719960796 0.00368098297503209 GO:0140658 ATP-dependent chromatin remodeler activity 23/1192 158/18639 0.145569620253165 2.27623502676068 0.000180886922597085 0.00436881241316002 GO:0031072 heat shock protein binding 20/1192 131/18639 0.152671755725191 2.38728930785389 0.000245049576454714 0.0057925548817274 GO:0008094 ATP-dependent activity, acting on DNA 27/1192 210/18639 0.128571428571429 2.01043863854267 0.000418396101523641 0.00968412643318261 GO:0030169 low-density lipoprotein particle binding 6/1192 17/18639 0.352941176470588 5.51885116462693 0.000453118171374711 0.0102737609877001 GO:0042162 telomeric DNA binding 9/1192 38/18639 0.236842105263158 3.70343959731544 0.000522436598016151 0.0111975137412396 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/1192 54/18639 0.203703703703704 3.18526286353468 0.000523630851398772 0.0111975137412396 GO:0003712 transcription coregulator activity 51/1192 495/18639 0.103030303030303 1.61105857230018 0.000524096052695282 0.0111975137412396 GO:0003697 single-stranded DNA binding 18/1192 121/18639 0.148760330578512 2.32612735037994 0.000673902691171707 0.014126526224373 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 7/1192 25/18639 0.28 4.37828859060403 0.000744304103022952 0.0153133677492315 GO:0051087 protein-folding chaperone binding 19/1192 134/18639 0.141791044776119 2.21715040568967 0.000883494208400122 0.0178465830096825 GO:0042287 MHC protein binding 9/1192 41/18639 0.219512195121951 3.43245621214601 0.000944463668264555 0.0187374845614629 GO:0008157 protein phosphatase 1 binding 7/1192 26/18639 0.269230769230769 4.2098928755808 0.000962834507098963 0.0187668269717008 GO:0036002 pre-mRNA binding 11/1192 59/18639 0.186440677966102 2.91532533272665 0.00114236442416561 0.0218821875042757 GO:0016004 phospholipase activator activity 6/1192 20/18639 0.3 4.69102348993289 0.00120234584793733 0.0226407836789554 GO:0016651 oxidoreductase activity, acting on NAD(P)H 14/1192 88/18639 0.159090909090909 2.48766397193411 0.00133274123914419 0.0246779252781532 GO:0004129 cytochrome-c oxidase activity 5/1192 15/18639 0.333333333333333 5.21224832214765 0.00185473289579587 0.0332356168907938 GO:0015929 hexosaminidase activity 5/1192 15/18639 0.333333333333333 5.21224832214765 0.00185473289579587 0.0332356168907938 GO:0043394 proteoglycan binding 8/1192 37/18639 0.216216216216216 3.38091783058226 0.00199402097787677 0.0346470826140713 GO:0017069 snRNA binding 10/1192 54/18639 0.185185185185185 2.89569351230425 0.00199587154572508 0.0346470826140713 GO:0070034 telomerase RNA binding 6/1192 22/18639 0.272727272727273 4.2645668090299 0.0020731765936049 0.0354353722383854 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/1192 16/18639 0.3125 4.88648280201342 0.00255693160915949 0.0400328672202179 GO:0017070 U6 snRNA binding 5/1192 16/18639 0.3125 4.88648280201342 0.00255693160915949 0.0400328672202179 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 4/1192 10/18639 0.4 6.25469798657718 0.00255835605097702 0.0400328672202179 GO:0031720 haptoglobin binding 4/1192 10/18639 0.4 6.25469798657718 0.00255835605097702 0.0400328672202179 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/1192 10/18639 0.4 6.25469798657718 0.00255835605097702 0.0400328672202179 GO:0051880 G-quadruplex DNA binding 4/1192 10/18639 0.4 6.25469798657718 0.00255835605097702 0.0400328672202179 GO:0042171 lysophosphatidic acid acyltransferase activity 6/1192 23/18639 0.260869565217391 4.0791508608112 0.00265493774024457 0.0404059702659139 GO:0071617 lysophospholipid acyltransferase activity 6/1192 23/18639 0.260869565217391 4.0791508608112 0.00265493774024457 0.0404059702659139 GO:0140097 catalytic activity, acting on DNA 35/1192 336/18639 0.104166666666667 1.62882760067114 0.00308159771513468 0.0462656089393869 GO:0060229 lipase activator activity 6/1192 24/18639 0.25 3.90918624161074 0.00335094065910878 0.0496386009635981 GO:0071813 lipoprotein particle binding 7/1192 32/18639 0.21875 3.4205379614094 0.0035207128806513 0.0507988572779688 GO:0071814 protein-lipid complex binding 7/1192 32/18639 0.21875 3.4205379614094 0.0035207128806513 0.0507988572779688 GO:0019887 protein kinase regulator activity 28/1192 255/18639 0.109803921568627 1.71697591788393 0.00369214418250616 0.0525893870097992 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 4/1192 11/18639 0.363636363636364 5.68608907870653 0.00381801701496478 0.0530227112953234 GO:0042608 T cell receptor binding 4/1192 11/18639 0.363636363636364 5.68608907870653 0.00381801701496478 0.0530227112953234 GO:0031593 polyubiquitin modification-dependent protein binding 10/1192 59/18639 0.169491525423729 2.65029575702423 0.00392509252862244 0.0538367629543152 GO:0003743 translation initiation factor activity 9/1192 51/18639 0.176470588235294 2.75942558231346 0.0046219468312349 0.062621743042707 GO:0004386 helicase activity 19/1192 155/18639 0.12258064516129 1.91676228620914 0.00479312572527485 0.0641585865154259 GO:0015035 protein-disulfide reductase activity 7/1192 34/18639 0.205882352941176 3.21932984603237 0.0050335778337762 0.0657918232155924 GO:0090482 vitamin transmembrane transporter activity 7/1192 34/18639 0.205882352941176 3.21932984603237 0.0050335778337762 0.0657918232155924 GO:0019207 kinase regulator activity 30/1192 287/18639 0.104529616724739 1.63450295816477 0.00556345528967318 0.0717048712820179 GO:0005126 cytokine receptor binding 29/1192 275/18639 0.105454545454545 1.64896583282489 0.00561505292667467 0.0717048712820179 GO:0005518 collagen binding 11/1192 72/18639 0.152777777777778 2.38894714765101 0.00578708231470803 0.0722409938386587 GO:0042379 chemokine receptor binding 11/1192 72/18639 0.152777777777778 2.38894714765101 0.00578708231470803 0.0722409938386587 GO:0030547 signaling receptor inhibitor activity 8/1192 44/18639 0.181818181818182 2.84304453935326 0.00616074525847727 0.0760509775796472 GO:0035255 ionotropic glutamate receptor binding 6/1192 27/18639 0.222222222222222 3.4748322147651 0.00625421625957563 0.076356420487786 GO:0004175 endopeptidase activity 39/1192 405/18639 0.0962962962962963 1.50576062639821 0.00706711237277062 0.0837170323460005 GO:0008009 chemokine activity 8/1192 45/18639 0.177777777777778 2.77986577181208 0.00708239446238559 0.0837170323460005 GO:0042826 histone deacetylase binding 16/1192 127/18639 0.125984251968504 1.96998361781958 0.00708316925339698 0.0837170323460005 GO:0003713 transcription coactivator activity 27/1192 256/18639 0.10546875 1.64918794567953 0.00733707990948307 0.0854499460371511 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/1192 13/18639 0.307692307692308 4.81130614352091 0.0074637932438382 0.0854499460371511 GO:0097157 pre-mRNA intronic binding 4/1192 13/18639 0.307692307692308 4.81130614352091 0.0074637932438382 0.0854499460371511 GO:0097718 disordered domain specific binding 6/1192 28/18639 0.214285714285714 3.35073106423778 0.00753743898437517 0.0854499460371511 GO:0008374 O-acyltransferase activity 9/1192 55/18639 0.163636363636364 2.55874008541794 0.0076904711229083 0.0863041759348598 GO:0051861 glycolipid binding 6/1192 29/18639 0.206896551724138 3.23518861374682 0.00900007180654832 0.0999907977707519 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 5/1192 21/18639 0.238095238095238 3.72303451581975 0.00912383920901574 0.100362231299173 GO:0043531 ADP binding 7/1192 38/18639 0.184210526315789 2.88045302013423 0.00945662893698871 0.102242570629864 GO:0043021 ribonucleoprotein complex binding 20/1192 177/18639 0.112994350282486 1.76686383801615 0.00947883418080645 0.102242570629864 GO:0032182 ubiquitin-like protein binding 15/1192 120/18639 0.125 1.95459312080537 0.0095911038982718 0.102458811836346 GO:0016504 peptidase activator activity 9/1192 57/18639 0.157894736842105 2.46895973154362 0.00971195711666054 0.102761755777237 GO:0005344 oxygen carrier activity 4/1192 14/18639 0.285714285714286 4.4676414189837 0.00992741736350211 0.104050572555197 GO:0001968 fibronectin binding 6/1192 30/18639 0.2 3.12734899328859 0.0106547881653895 0.10860063900686 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/1192 30/18639 0.2 3.12734899328859 0.0106547881653895 0.10860063900686 GO:0048019 receptor antagonist activity 6/1192 30/18639 0.2 3.12734899328859 0.0106547881653895 0.10860063900686 GO:0043130 ubiquitin binding 13/1192 100/18639 0.13 2.03277684563758 0.0111781547934881 0.112076514027179 GO:0061133 endopeptidase activator activity 5/1192 22/18639 0.227272727272727 3.55380567419158 0.011197563507666 0.112076514027179 GO:0008186 ATP-dependent activity, acting on RNA 11/1192 79/18639 0.139240506329114 2.17726828646674 0.0115445404994174 0.113512837061684 GO:0022804 active transmembrane transporter activity 42/1192 457/18639 0.0919037199124726 1.43707502973874 0.0115454100701802 0.113512837061684 GO:0002039 p53 binding 10/1192 69/18639 0.144927536231884 2.26619492267289 0.0119599912456404 0.115543915425274 GO:0008080 N-acetyltransferase activity 10/1192 69/18639 0.144927536231884 2.26619492267289 0.0119599912456404 0.115543915425274 GO:0043022 ribosome binding 14/1192 112/18639 0.125 1.95459312080537 0.0120758181963074 0.115657189793944 GO:0015036 disulfide oxidoreductase activity 7/1192 40/18639 0.175 2.73643036912752 0.0125070345641406 0.117821517423716 GO:0016411 acylglycerol O-acyltransferase activity 6/1192 31/18639 0.193548387096774 3.02646676769864 0.0125138965400527 0.117821517423716 GO:0097110 scaffold protein binding 10/1192 70/18639 0.142857142857143 2.23382070949185 0.0131778210534188 0.123029909162591 GO:0048020 CCR chemokine receptor binding 8/1192 50/18639 0.16 2.50187919463087 0.0133223962033546 0.123343184849391 GO:0001618 virus receptor activity 11/1192 81/18639 0.135802469135802 2.12350857568978 0.0138023673127356 0.126730827144208 GO:0031369 translation initiation factor binding 6/1192 32/18639 0.1875 2.93188968120805 0.0145892466152991 0.132544801046758 GO:0045296 cadherin binding 32/1192 334/18639 0.0958083832335329 1.49813125426998 0.0146777461950757 0.132544801046758 GO:0004518 nuclease activity 22/1192 209/18639 0.105263157894737 1.64597315436242 0.0147934791447326 0.132544801046758 GO:0140030 modification-dependent protein binding 19/1192 173/18639 0.109826589595376 1.71733037203709 0.0149153254672984 0.132567412753348 GO:0140272 exogenous protein binding 11/1192 82/18639 0.134146341463415 2.09761212964479 0.0150491769515747 0.132695520580949 GO:0140098 catalytic activity, acting on RNA 36/1192 387/18639 0.0930232558139535 1.45458092711097 0.0154755504484128 0.135380602741627 GO:0001540 amyloid-beta binding 11/1192 83/18639 0.132530120481928 2.07233969434786 0.0163787847301058 0.14216273308709 GO:0004860 protein kinase inhibitor activity 11/1192 84/18639 0.130952380952381 2.04766898370086 0.0177943152217491 0.153251815591963 GO:0008375 acetylglucosaminyltransferase activity 7/1192 43/18639 0.162790697674419 2.5455166224442 0.0183223961412348 0.155359861633314 GO:0048156 tau protein binding 7/1192 43/18639 0.162790697674419 2.5455166224442 0.0183223961412348 0.155359861633314 GO:0034212 protein N-acetyltransferase activity 8/1192 53/18639 0.150943396226415 2.3602633911612 0.0185984352810358 0.155359861633314 GO:0140296 general transcription initiation factor binding 8/1192 53/18639 0.150943396226415 2.3602633911612 0.0185984352810358 0.155359861633314 GO:0030332 cyclin binding 6/1192 34/18639 0.176470588235294 2.75942558231346 0.0194332634915152 0.161122057754279 GO:0005092 GDP-dissociation inhibitor activity 4/1192 17/18639 0.235294117647059 3.67923410975128 0.0202566607009689 0.165479044402768 GO:0032977 membrane insertase activity 4/1192 17/18639 0.235294117647059 3.67923410975128 0.0202566607009689 0.165479044402768 GO:0140297 DNA-binding transcription factor binding 43/1192 488/18639 0.0881147540983607 1.3778279376169 0.0206498648507247 0.166681570425158 GO:0003725 double-stranded RNA binding 10/1192 75/18639 0.133333333333333 2.08489932885906 0.0207039214389485 0.166681570425158 GO:0030695 GTPase regulator activity 43/1192 489/18639 0.0879345603271984 1.37501029357269 0.0212924799885769 0.169817774099029 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 23/1192 229/18639 0.100436681222707 1.57050276955541 0.0213991794544231 0.169817774099029 GO:0060589 nucleoside-triphosphatase regulator activity 43/1192 490/18639 0.0877551020408163 1.37220415011642 0.0219509714165562 0.170821667532169 GO:0008190 eukaryotic initiation factor 4E binding 3/1192 10/18639 0.3 4.69102348993289 0.0222944570586539 0.170821667532169 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/1192 10/18639 0.3 4.69102348993289 0.0222944570586539 0.170821667532169 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/1192 10/18639 0.3 4.69102348993289 0.0222944570586539 0.170821667532169 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/1192 10/18639 0.3 4.69102348993289 0.0222944570586539 0.170821667532169 GO:0004540 RNA nuclease activity 14/1192 121/18639 0.115702479338843 1.80921016140662 0.0224759127076238 0.171032459028562 GO:0046915 transition metal ion transmembrane transporter activity 7/1192 45/18639 0.155555555555556 2.43238255033557 0.0231176169541015 0.17471886010889 GO:0019001 guanyl nucleotide binding 36/1192 400/18639 0.09 1.40730704697987 0.0243080117265539 0.179926589381825 GO:0032561 guanyl ribonucleotide binding 36/1192 400/18639 0.09 1.40730704697987 0.0243080117265539 0.179926589381825 GO:0004197 cysteine-type endopeptidase activity 11/1192 88/18639 0.125 1.95459312080537 0.0243768839499224 0.179926589381825 GO:0003724 RNA helicase activity 10/1192 77/18639 0.12987012987013 2.03074609953805 0.0244544689438844 0.179926589381825 GO:0030228 lipoprotein particle receptor activity 4/1192 18/18639 0.222222222222222 3.4748322147651 0.0247566319414212 0.180951434782361 GO:0003727 single-stranded RNA binding 11/1192 89/18639 0.123595505617978 1.93263140034688 0.0262675041469854 0.190739850374515 GO:0002020 protease binding 15/1192 136/18639 0.110294117647059 1.72464098894591 0.0273807539156344 0.197532581819934 GO:0005525 GTP binding 34/1192 378/18639 0.0899470899470899 1.40647970597635 0.0281866376934495 0.201055038912414 GO:0019210 kinase inhibitor activity 11/1192 90/18639 0.122222222222222 1.91115771812081 0.028261839140365 0.201055038912414 GO:0030145 manganese ion binding 9/1192 68/18639 0.132352941176471 2.0695691867351 0.028583240560532 0.201055038912414 GO:0061733 protein-lysine-acetyltransferase activity 7/1192 47/18639 0.148936170212766 2.32887690989576 0.0287137044947263 0.201055038912414 GO:0005178 integrin binding 17/1192 161/18639 0.105590062111801 1.65108487223311 0.0287738534537118 0.201055038912414 GO:0008238 exopeptidase activity 12/1192 102/18639 0.117647058823529 1.83961705487564 0.0294511903902535 0.20319771073705 GO:0003756 protein disulfide isomerase activity 4/1192 19/18639 0.210526315789474 3.29194630872483 0.0298120853736626 0.20319771073705 GO:0015245 fatty acid transmembrane transporter activity 4/1192 19/18639 0.210526315789474 3.29194630872483 0.0298120853736626 0.20319771073705 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4/1192 19/18639 0.210526315789474 3.29194630872483 0.0298120853736626 0.20319771073705 GO:0008234 cysteine-type peptidase activity 19/1192 187/18639 0.101604278074866 1.58876018375624 0.0308294252494351 0.208850557634893 GO:0140693 molecular condensate scaffold activity 7/1192 48/18639 0.145833333333333 2.2803586409396 0.0318277036525235 0.214306537926992 GO:0004842 ubiquitin-protein transferase activity 39/1192 449/18639 0.0868596881959911 1.35820279218547 0.0321827989867796 0.21539210647176 GO:0004879 nuclear receptor activity 8/1192 59/18639 0.135593220338983 2.12023660561938 0.0333332042959199 0.221755628579443 GO:0035254 glutamate receptor binding 7/1192 49/18639 0.142857142857143 2.23382070949185 0.0351597164907245 0.23020705072601 GO:0060590 ATPase regulator activity 7/1192 49/18639 0.142857142857143 2.23382070949185 0.0351597164907245 0.23020705072601 GO:0000339 RNA cap binding 4/1192 20/18639 0.2 3.12734899328859 0.0354324083475677 0.23020705072601 GO:0043024 ribosomal small subunit binding 4/1192 20/18639 0.2 3.12734899328859 0.0354324083475677 0.23020705072601 GO:0098531 ligand-modulated transcription factor activity 8/1192 60/18639 0.133333333333333 2.08489932885906 0.0363902411817696 0.235055569493872 GO:0031543 peptidyl-proline dioxygenase activity 3/1192 12/18639 0.25 3.90918624161074 0.0371509659506119 0.237211052707642 GO:0035259 nuclear glucocorticoid receptor binding 3/1192 12/18639 0.25 3.90918624161074 0.0371509659506119 0.237211052707642 GO:0015605 organophosphate ester transmembrane transporter activity 7/1192 50/18639 0.14 2.18914429530201 0.0387146290956451 0.245782588144353 GO:0004177 aminopeptidase activity 6/1192 40/18639 0.15 2.34551174496644 0.0401858256675292 0.252446120202165 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 31/1192 349/18639 0.0888252148997135 1.38893723197631 0.0402186888170866 0.252446120202165 GO:0005096 GTPase activator activity 25/1192 271/18639 0.0922509225092251 1.44250414819584 0.0419150583674108 0.261615898012322 GO:0019903 protein phosphatase binding 15/1192 144/18639 0.104166666666667 1.62882760067114 0.0423768965344793 0.262639640156069 GO:0016407 acetyltransferase activity 11/1192 96/18639 0.114583333333333 1.79171036073825 0.0425518768929725 0.262639640156069 GO:0008194 UDP-glycosyltransferase activity 15/1192 145/18639 0.103448275862069 1.61759430687341 0.0445951639332165 0.273730536628749 GO:0061630 ubiquitin protein ligase activity 31/1192 353/18639 0.0878186968838527 1.37319856645816 0.0456892543057242 0.278094879534225 GO:0002161 aminoacyl-tRNA editing activity 3/1192 13/18639 0.230769230769231 3.60847960764068 0.046057117762644 0.278094879534225 GO:0005172 vascular endothelial growth factor receptor binding 3/1192 13/18639 0.230769230769231 3.60847960764068 0.046057117762644 0.278094879534225 GO:0016209 antioxidant activity 10/1192 86/18639 0.116279069767442 1.81822615888872 0.047448734490119 0.284948886586607 GO:0008649 rRNA methyltransferase activity 4/1192 22/18639 0.181818181818182 2.84304453935326 0.0483837924433386 0.287946982203594 GO:0004222 metalloendopeptidase activity 12/1192 110/18639 0.109090909090909 1.70582672361196 0.0484663237372385 0.287946982203594 GO:0004402 histone acetyltransferase activity 6/1192 42/18639 0.142857142857143 2.23382070949185 0.0493649158226011 0.290182124227036 GO:0042056 chemoattractant activity 6/1192 42/18639 0.142857142857143 2.23382070949185 0.0493649158226011 0.290182124227036 GO:0070717 poly-purine tract binding 5/1192 32/18639 0.15625 2.44324140100671 0.0506886430753384 0.294138026772648 GO:0016860 intramolecular oxidoreductase activity 7/1192 53/18639 0.132075471698113 2.06523046726605 0.0507573681453078 0.294138026772648 GO:0019787 ubiquitin-like protein transferase activity 40/1192 479/18639 0.0835073068893528 1.30578246066329 0.0508321342397375 0.294138026772648 GO:0004712 protein serine/threonine/tyrosine kinase activity 6/1192 43/18639 0.13953488372093 2.18187139066646 0.0543988379330929 0.31204826150863 GO:0019843 rRNA binding 8/1192 65/18639 0.123076923076923 1.92452245740836 0.0544890753669435 0.31204826150863 GO:0070577 lysine-acetylated histone binding 4/1192 23/18639 0.173913043478261 2.71943390720747 0.0557129034609409 0.312144507815264 GO:0140102 catalytic activity, acting on a rRNA 4/1192 23/18639 0.173913043478261 2.71943390720747 0.0557129034609409 0.312144507815264 GO:0005161 platelet-derived growth factor receptor binding 3/1192 14/18639 0.214285714285714 3.35073106423778 0.0559106724169554 0.312144507815264 GO:0070742 C2H2 zinc finger domain binding 3/1192 14/18639 0.214285714285714 3.35073106423778 0.0559106724169554 0.312144507815264 GO:0098847 sequence-specific single stranded DNA binding 3/1192 14/18639 0.214285714285714 3.35073106423778 0.0559106724169554 0.312144507815264 GO:0004857 enzyme inhibitor activity 35/1192 416/18639 0.0841346153846154 1.315591523619 0.0590506557117461 0.328026392478749 GO:0019902 phosphatase binding 18/1192 190/18639 0.0947368421052632 1.48137583892617 0.0614954667005348 0.336492848893112 GO:0004519 endonuclease activity 13/1192 127/18639 0.102362204724409 1.60061168947841 0.0626946855141169 0.336492848893112 GO:0019825 oxygen binding 5/1192 34/18639 0.147058823529412 2.29952131859455 0.063153123667355 0.336492848893112 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/1192 24/18639 0.166666666666667 2.60612416107383 0.0636035087916773 0.336492848893112 GO:0015149 hexose transmembrane transporter activity 4/1192 24/18639 0.166666666666667 2.60612416107383 0.0636035087916773 0.336492848893112 GO:0015295 solute:proton symporter activity 4/1192 24/18639 0.166666666666667 2.60612416107383 0.0636035087916773 0.336492848893112 GO:0035035 histone acetyltransferase binding 4/1192 24/18639 0.166666666666667 2.60612416107383 0.0636035087916773 0.336492848893112 GO:0048027 mRNA 5'-UTR binding 4/1192 24/18639 0.166666666666667 2.60612416107383 0.0636035087916773 0.336492848893112 GO:0055056 D-glucose transmembrane transporter activity 4/1192 24/18639 0.166666666666667 2.60612416107383 0.0636035087916773 0.336492848893112 GO:0140033 acetylation-dependent protein binding 4/1192 24/18639 0.166666666666667 2.60612416107383 0.0636035087916773 0.336492848893112 GO:0003714 transcription corepressor activity 19/1192 204/18639 0.0931372549019608 1.45636350177655 0.0640718103734395 0.33736389253503 GO:0000774 adenyl-nucleotide exchange factor activity 3/1192 15/18639 0.2 3.12734899328859 0.0666726057741635 0.344526814023701 GO:0005041 low-density lipoprotein particle receptor activity 3/1192 15/18639 0.2 3.12734899328859 0.0666726057741635 0.344526814023701 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/1192 15/18639 0.2 3.12734899328859 0.0666726057741635 0.344526814023701 GO:0140776 protein-containing complex destabilizing activity 3/1192 15/18639 0.2 3.12734899328859 0.0666726057741635 0.344526814023701 GO:0016853 isomerase activity 17/1192 180/18639 0.0944444444444444 1.47680369127517 0.0692520208300864 0.35619905158438 GO:0004601 peroxidase activity 7/1192 57/18639 0.12280701754386 1.92030201342282 0.0701327058520544 0.359066526274804 GO:0051213 dioxygenase activity 10/1192 93/18639 0.10752688172043 1.68137042649924 0.0731082823349814 0.372583952633781 GO:0016755 aminoacyltransferase activity 40/1192 496/18639 0.0806451612903226 1.26102781987443 0.0773652367337639 0.390706702077065 GO:0016410 N-acyltransferase activity 10/1192 94/18639 0.106382978723404 1.6634835070684 0.0773676637776367 0.390706702077065 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/1192 16/18639 0.1875 2.93188968120805 0.0782974513879451 0.390848255390996 GO:0005521 lamin binding 3/1192 16/18639 0.1875 2.93188968120805 0.0782974513879451 0.390848255390996 GO:0061659 ubiquitin-like protein ligase activity 31/1192 372/18639 0.0833333333333333 1.30306208053691 0.0793298889796005 0.390848255390996 GO:0003924 GTPase activity 28/1192 331/18639 0.0845921450151057 1.32274579776557 0.0796787149515448 0.390848255390996 GO:0019888 protein phosphatase regulator activity 11/1192 107/18639 0.102803738317757 1.60751583767171 0.0802480374820568 0.390848255390996 GO:0016758 hexosyltransferase activity 18/1192 197/18639 0.0913705583756345 1.42873811876128 0.0807454730278272 0.390848255390996 GO:0008143 poly(A) binding 4/1192 26/18639 0.153846153846154 2.40565307176045 0.0810270880588511 0.390848255390996 GO:0015145 monosaccharide transmembrane transporter activity 4/1192 26/18639 0.153846153846154 2.40565307176045 0.0810270880588511 0.390848255390996 GO:0070006 metalloaminopeptidase activity 4/1192 26/18639 0.153846153846154 2.40565307176045 0.0810270880588511 0.390848255390996 GO:0008237 metallopeptidase activity 17/1192 184/18639 0.0923913043478261 1.44469926320397 0.0811274600368486 0.390848255390996 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/1192 59/18639 0.11864406779661 1.85520702991696 0.0812654788436725 0.390848255390996 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 9/1192 83/18639 0.108433734939759 1.69555065901189 0.0827040725870802 0.396052692432096 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 7/1192 60/18639 0.116666666666667 1.82428691275168 0.0871923970254334 0.415754305129856 GO:0004527 exonuclease activity 9/1192 84/18639 0.107142857142857 1.67536553211889 0.0876590442007979 0.416193154303788 GO:0004683 calcium/calmodulin-dependent protein kinase activity 4/1192 27/18639 0.148148148148148 2.3165548098434 0.0905318032666122 0.41828349562768 GO:0005385 zinc ion transmembrane transporter activity 4/1192 27/18639 0.148148148148148 2.3165548098434 0.0905318032666122 0.41828349562768 GO:0004549 tRNA-specific ribonuclease activity 3/1192 17/18639 0.176470588235294 2.75942558231346 0.0907347636780115 0.41828349562768 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/1192 17/18639 0.176470588235294 2.75942558231346 0.0907347636780115 0.41828349562768 GO:0032183 SUMO binding 3/1192 17/18639 0.176470588235294 2.75942558231346 0.0907347636780115 0.41828349562768 GO:0051787 misfolded protein binding 3/1192 17/18639 0.176470588235294 2.75942558231346 0.0907347636780115 0.41828349562768 GO:1990226 histone methyltransferase binding 3/1192 17/18639 0.176470588235294 2.75942558231346 0.0907347636780115 0.41828349562768 GO:0042887 amide transmembrane transporter activity 5/1192 38/18639 0.131578947368421 2.05746644295302 0.0927512239477243 0.425812437214552 GO:0004521 RNA endonuclease activity 8/1192 73/18639 0.10958904109589 1.71361588673347 0.093717170734713 0.428476447268585 GO:0003735 structural constituent of ribosome 16/1192 175/18639 0.0914285714285714 1.42964525407478 0.094979642382769 0.432468781505149 GO:0032813 tumor necrosis factor receptor superfamily binding 6/1192 50/18639 0.12 1.87640939597315 0.097994963083112 0.444377159123826 GO:0003678 DNA helicase activity 8/1192 74/18639 0.108108108108108 1.69045891529113 0.0995228700656255 0.446809040992843 GO:0048029 monosaccharide binding 8/1192 74/18639 0.108108108108108 1.69045891529113 0.0995228700656255 0.446809040992843 GO:0046966 nuclear thyroid hormone receptor binding 4/1192 28/18639 0.142857142857143 2.23382070949185 0.100542088432233 0.446809040992843 GO:0051119 sugar transmembrane transporter activity 4/1192 28/18639 0.142857142857143 2.23382070949185 0.100542088432233 0.446809040992843 GO:0051537 2 iron, 2 sulfur cluster binding 4/1192 28/18639 0.142857142857143 2.23382070949185 0.100542088432233 0.446809040992843 GO:0000900 mRNA regulatory element binding translation repressor activity 3/1192 18/18639 0.166666666666667 2.60612416107383 0.103930390025329 0.454593162669846 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/1192 18/18639 0.166666666666667 2.60612416107383 0.103930390025329 0.454593162669846 GO:0034185 apolipoprotein binding 3/1192 18/18639 0.166666666666667 2.60612416107383 0.103930390025329 0.454593162669846 GO:0050811 GABA receptor binding 3/1192 18/18639 0.166666666666667 2.60612416107383 0.103930390025329 0.454593162669846 GO:1901682 sulfur compound transmembrane transporter activity 7/1192 63/18639 0.111111111111111 1.73741610738255 0.106395346299309 0.463549920543262 GO:0030295 protein kinase activator activity 13/1192 139/18639 0.0935251798561151 1.46242938535078 0.108266852807774 0.469861224489988 GO:0004629 phospholipase C activity 4/1192 29/18639 0.137931034482759 2.15679240916455 0.11103794046885 0.480012264050166 GO:0043395 heparan sulfate proteoglycan binding 3/1192 19/18639 0.157894736842105 2.46895973154362 0.117827572147517 0.503486279445736 GO:0070003 threonine-type peptidase activity 3/1192 19/18639 0.157894736842105 2.46895973154362 0.117827572147517 0.503486279445736 GO:0097001 ceramide binding 3/1192 19/18639 0.157894736842105 2.46895973154362 0.117827572147517 0.503486279445736 GO:0042169 SH2 domain binding 5/1192 41/18639 0.121951219512195 1.9069201178589 0.118843521974288 0.505881811928867 GO:0004864 protein phosphatase inhibitor activity 6/1192 53/18639 0.113207547169811 1.7701975433709 0.121030826855049 0.513226139831905 GO:0008187 poly-pyrimidine tract binding 4/1192 30/18639 0.133333333333333 2.08489932885906 0.121997522354677 0.51535835488991 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 9/1192 91/18639 0.0989010989010989 1.54649126041743 0.127118804213462 0.528270754739178 GO:0019208 phosphatase regulator activity 11/1192 117/18639 0.094017094017094 1.47012132163139 0.128396765120718 0.528270754739178 GO:0003925 G protein activity 6/1192 54/18639 0.111111111111111 1.73741610738255 0.129254477597203 0.528270754739178 GO:0140463 chromatin-protein adaptor activity 6/1192 54/18639 0.111111111111111 1.73741610738255 0.129254477597203 0.528270754739178 GO:0001094 TFIID-class transcription factor complex binding 2/1192 10/18639 0.2 3.12734899328859 0.130760087806727 0.528270754739178 GO:0004090 carbonyl reductase (NADPH) activity 2/1192 10/18639 0.2 3.12734899328859 0.130760087806727 0.528270754739178 GO:0005031 tumor necrosis factor receptor activity 2/1192 10/18639 0.2 3.12734899328859 0.130760087806727 0.528270754739178 GO:0005381 iron ion transmembrane transporter activity 2/1192 10/18639 0.2 3.12734899328859 0.130760087806727 0.528270754739178 GO:0030957 Tat protein binding 2/1192 10/18639 0.2 3.12734899328859 0.130760087806727 0.528270754739178 GO:0043422 protein kinase B binding 2/1192 10/18639 0.2 3.12734899328859 0.130760087806727 0.528270754739178 GO:0050308 sugar-phosphatase activity 2/1192 10/18639 0.2 3.12734899328859 0.130760087806727 0.528270754739178 GO:0141109 transporter activator activity 2/1192 10/18639 0.2 3.12734899328859 0.130760087806727 0.528270754739178 GO:0030742 GTP-dependent protein binding 3/1192 20/18639 0.15 2.34551174496644 0.132367895171038 0.530905167996472 GO:0031418 L-ascorbic acid binding 3/1192 20/18639 0.15 2.34551174496644 0.132367895171038 0.530905167996472 GO:0008201 heparin binding 15/1192 172/18639 0.0872093023255814 1.36366961916654 0.1376309659627 0.545970532704871 GO:1990841 promoter-specific chromatin binding 7/1192 68/18639 0.102941176470588 1.60966492301619 0.142952294304333 0.545970532704871 GO:0022884 macromolecule transmembrane transporter activity 4/1192 32/18639 0.125 1.95459312080537 0.145212976639234 0.545970532704871 GO:0043425 bHLH transcription factor binding 4/1192 32/18639 0.125 1.95459312080537 0.145212976639234 0.545970532704871 GO:0051059 NF-kappaB binding 4/1192 32/18639 0.125 1.95459312080537 0.145212976639234 0.545970532704871 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1192 81/18639 0.0987654320987654 1.54436987322893 0.145562462082 0.545970532704871 GO:0140791 histone H2AXS140 phosphatase activity 8/1192 81/18639 0.0987654320987654 1.54436987322893 0.145562462082 0.545970532704871 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1192 81/18639 0.0987654320987654 1.54436987322893 0.145562462082 0.545970532704871 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1192 81/18639 0.0987654320987654 1.54436987322893 0.145562462082 0.545970532704871 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1192 81/18639 0.0987654320987654 1.54436987322893 0.145562462082 0.545970532704871 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1192 81/18639 0.0987654320987654 1.54436987322893 0.145562462082 0.545970532704871 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1192 81/18639 0.0987654320987654 1.54436987322893 0.145562462082 0.545970532704871 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1192 81/18639 0.0987654320987654 1.54436987322893 0.145562462082 0.545970532704871 GO:0019212 phosphatase inhibitor activity 6/1192 56/18639 0.107142857142857 1.67536553211889 0.146476227236331 0.545970532704871 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/1192 21/18639 0.142857142857143 2.23382070949185 0.147492101047947 0.545970532704871 GO:0070182 DNA polymerase binding 3/1192 21/18639 0.142857142857143 2.23382070949185 0.147492101047947 0.545970532704871 GO:0001046 core promoter sequence-specific DNA binding 5/1192 44/18639 0.113636363636364 1.77690283709579 0.147975129506044 0.545970532704871 GO:0019209 kinase activator activity 13/1192 148/18639 0.0878378378378378 1.37349786867404 0.15265867692747 0.545970532704871 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1192 82/18639 0.0975609756097561 1.52553609428712 0.15287496556586 0.545970532704871 GO:0033549 MAP kinase phosphatase activity 8/1192 82/18639 0.0975609756097561 1.52553609428712 0.15287496556586 0.545970532704871 GO:0000099 sulfur amino acid transmembrane transporter activity 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0001851 complement component C3b binding 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0005225 volume-sensitive anion channel activity 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0005536 D-glucose binding 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0015173 aromatic amino acid transmembrane transporter activity 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0019203 carbohydrate phosphatase activity 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0031731 CCR6 chemokine receptor binding 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0043522 leucine zipper domain binding 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0047676 arachidonate-CoA ligase activity 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0048407 platelet-derived growth factor binding 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0070697 activin receptor binding 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0140031 phosphorylation-dependent protein binding 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0180030 inositol phosphate kinase activity 2/1192 11/18639 0.181818181818182 2.84304453935326 0.153323857969325 0.545970532704871 GO:0030296 protein tyrosine kinase activator activity 4/1192 33/18639 0.121212121212121 1.89536302623551 0.15741838962878 0.558759843059343 GO:0044325 transmembrane transporter binding 12/1192 136/18639 0.0882352941176471 1.37971279115673 0.160926364746677 0.569392328769294 GO:0008408 3'-5' exonuclease activity 6/1192 58/18639 0.103448275862069 1.61759430687341 0.164674650969135 0.578966889957939 GO:0017116 single-stranded DNA helicase activity 6/1192 58/18639 0.103448275862069 1.61759430687341 0.164674650969135 0.578966889957939 GO:0016922 nuclear receptor binding 12/1192 137/18639 0.0875912408759124 1.36964189487092 0.1668154372805 0.584643377976769 GO:0017018 myosin phosphatase activity 8/1192 84/18639 0.0952380952380952 1.4892138063279 0.16801257835547 0.586987341361408 GO:0030291 protein serine/threonine kinase inhibitor activity 5/1192 46/18639 0.108695652173913 1.69964619200467 0.168911639153787 0.588278467397672 GO:0008376 acetylgalactosaminyltransferase activity 4/1192 34/18639 0.117647058823529 1.83961705487564 0.16998709175697 0.588335386112129 GO:0016831 carboxy-lyase activity 4/1192 34/18639 0.117647058823529 1.83961705487564 0.16998709175697 0.588335386112129 GO:0045309 protein phosphorylated amino acid binding 6/1192 59/18639 0.101694915254237 1.59017745421454 0.174117198756923 0.59083259882674 GO:0070063 RNA polymerase binding 6/1192 59/18639 0.101694915254237 1.59017745421454 0.174117198756923 0.59083259882674 GO:0000340 RNA 7-methylguanosine cap binding 2/1192 12/18639 0.166666666666667 2.60612416107383 0.176558436373067 0.59083259882674 GO:0003995 acyl-CoA dehydrogenase activity 2/1192 12/18639 0.166666666666667 2.60612416107383 0.176558436373067 0.59083259882674 GO:0004526 ribonuclease P activity 2/1192 12/18639 0.166666666666667 2.60612416107383 0.176558436373067 0.59083259882674 GO:0005049 nuclear export signal receptor activity 2/1192 12/18639 0.166666666666667 2.60612416107383 0.176558436373067 0.59083259882674 GO:0043047 single-stranded telomeric DNA binding 2/1192 12/18639 0.166666666666667 2.60612416107383 0.176558436373067 0.59083259882674 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/1192 12/18639 0.166666666666667 2.60612416107383 0.176558436373067 0.59083259882674 GO:0070008 serine-type exopeptidase activity 2/1192 12/18639 0.166666666666667 2.60612416107383 0.176558436373067 0.59083259882674 GO:0097677 STAT family protein binding 2/1192 12/18639 0.166666666666667 2.60612416107383 0.176558436373067 0.59083259882674 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/1192 12/18639 0.166666666666667 2.60612416107383 0.176558436373067 0.59083259882674 GO:0140103 catalytic activity, acting on a glycoprotein 3/1192 23/18639 0.130434782608696 2.0395754304056 0.179254963037887 0.594485755066816 GO:0001784 phosphotyrosine residue binding 5/1192 47/18639 0.106382978723404 1.6634835070684 0.179790471379343 0.594485755066816 GO:0061749 forked DNA-dependent helicase activity 5/1192 47/18639 0.106382978723404 1.6634835070684 0.179790471379343 0.594485755066816 GO:1990518 single-stranded 3'-5' DNA helicase activity 5/1192 47/18639 0.106382978723404 1.6634835070684 0.179790471379343 0.594485755066816 GO:0016874 ligase activity 14/1192 167/18639 0.0838323353293413 1.31086484748624 0.182273113779546 0.597001730050083 GO:0005154 epidermal growth factor receptor binding 4/1192 35/18639 0.114285714285714 1.78705656759348 0.182891893429894 0.597001730050083 GO:0016229 steroid dehydrogenase activity 4/1192 35/18639 0.114285714285714 1.78705656759348 0.182891893429894 0.597001730050083 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 15/1192 181/18639 0.0828729281767956 1.2958628425229 0.183164313094378 0.597001730050083 GO:0001098 basal transcription machinery binding 6/1192 60/18639 0.1 1.5636744966443 0.183775510060422 0.597001730050083 GO:0001099 basal RNA polymerase II transcription machinery binding 6/1192 60/18639 0.1 1.5636744966443 0.183775510060422 0.597001730050083 GO:0030246 carbohydrate binding 22/1192 280/18639 0.0785714285714286 1.22860139022052 0.185937216712332 0.602263113024494 GO:0009378 four-way junction helicase activity 5/1192 48/18639 0.104166666666667 1.62882760067114 0.190922122801851 0.608895383908436 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/1192 48/18639 0.104166666666667 1.62882760067114 0.190922122801851 0.608895383908436 GO:0036121 double-stranded DNA helicase activity 5/1192 48/18639 0.104166666666667 1.62882760067114 0.190922122801851 0.608895383908436 GO:0043138 3'-5' DNA helicase activity 5/1192 48/18639 0.104166666666667 1.62882760067114 0.190922122801851 0.608895383908436 GO:0016757 glycosyltransferase activity 21/1192 267/18639 0.0786516853932584 1.22985634567529 0.191359121184021 0.608895383908436 GO:0031491 nucleosome binding 7/1192 74/18639 0.0945945945945946 1.47915155087974 0.193574833605191 0.608895383908436 GO:0005315 phosphate transmembrane transporter activity 3/1192 24/18639 0.125 1.95459312080537 0.195776599358775 0.608895383908436 GO:0005540 hyaluronic acid binding 3/1192 24/18639 0.125 1.95459312080537 0.195776599358775 0.608895383908436 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/1192 24/18639 0.125 1.95459312080537 0.195776599358775 0.608895383908436 GO:0070300 phosphatidic acid binding 3/1192 24/18639 0.125 1.95459312080537 0.195776599358775 0.608895383908436 GO:0031490 chromatin DNA binding 11/1192 128/18639 0.0859375 1.34378277055369 0.195968347140219 0.608895383908436 GO:0016409 palmitoyltransferase activity 4/1192 36/18639 0.111111111111111 1.73741610738255 0.196105199217204 0.608895383908436 GO:0020037 heme binding 12/1192 142/18639 0.0845070422535211 1.32141506758673 0.197805801279089 0.608895383908436 GO:0001664 G protein-coupled receptor binding 23/1192 297/18639 0.0774410774410774 1.21092637787269 0.197942018774849 0.608895383908436 GO:0061134 peptidase regulator activity 18/1192 226/18639 0.079646017699115 1.24540446635386 0.198709572819507 0.608895383908436 GO:0005035 death receptor activity 2/1192 13/18639 0.153846153846154 2.40565307176045 0.20028594884769 0.608895383908436 GO:0008035 high-density lipoprotein particle binding 2/1192 13/18639 0.153846153846154 2.40565307176045 0.20028594884769 0.608895383908436 GO:0017154 semaphorin receptor activity 2/1192 13/18639 0.153846153846154 2.40565307176045 0.20028594884769 0.608895383908436 GO:0035673 oligopeptide transmembrane transporter activity 2/1192 13/18639 0.153846153846154 2.40565307176045 0.20028594884769 0.608895383908436 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1192 13/18639 0.153846153846154 2.40565307176045 0.20028594884769 0.608895383908436 GO:0140666 annealing activity 2/1192 13/18639 0.153846153846154 2.40565307176045 0.20028594884769 0.608895383908436 GO:0017124 SH3 domain binding 10/1192 115/18639 0.0869565217391304 1.35971695360374 0.200438509856088 0.608895383908436 GO:0008514 organic anion transmembrane transporter activity 21/1192 269/18639 0.0780669144981413 1.22071243232454 0.200590198479287 0.608895383908436 GO:0019003 GDP binding 7/1192 75/18639 0.0933333333333333 1.45942953020134 0.202638664884974 0.613437484161324 GO:0005539 glycosaminoglycan binding 19/1192 242/18639 0.0785123966942149 1.22767832381164 0.207870435252506 0.627565362949821 GO:0004722 protein serine/threonine phosphatase activity 9/1192 103/18639 0.087378640776699 1.36631752133968 0.212586215600245 0.631692549419682 GO:0001848 complement binding 3/1192 25/18639 0.12 1.87640939597315 0.212648977032368 0.631692549419682 GO:0003707 nuclear steroid receptor activity 3/1192 25/18639 0.12 1.87640939597315 0.212648977032368 0.631692549419682 GO:0015645 fatty acid ligase activity 3/1192 25/18639 0.12 1.87640939597315 0.212648977032368 0.631692549419682 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/1192 25/18639 0.12 1.87640939597315 0.212648977032368 0.631692549419682 GO:0120515 fatty acid-CoA ligase activity 3/1192 25/18639 0.12 1.87640939597315 0.212648977032368 0.631692549419682 GO:0008494 translation activator activity 2/1192 14/18639 0.142857142857143 2.23382070949185 0.224348494919479 0.659394650411484 GO:0015926 glucosidase activity 2/1192 14/18639 0.142857142857143 2.23382070949185 0.224348494919479 0.659394650411484 GO:0019763 immunoglobulin receptor activity 2/1192 14/18639 0.142857142857143 2.23382070949185 0.224348494919479 0.659394650411484 GO:0044548 S100 protein binding 2/1192 14/18639 0.142857142857143 2.23382070949185 0.224348494919479 0.659394650411484 GO:0016830 carbon-carbon lyase activity 5/1192 51/18639 0.0980392156862745 1.53301421239637 0.225670522167078 0.661530211418533 GO:0004435 phosphatidylinositol phospholipase C activity 3/1192 26/18639 0.115384615384615 1.80423980382034 0.229817049507175 0.664913390631435 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1192 26/18639 0.115384615384615 1.80423980382034 0.229817049507175 0.664913390631435 GO:0019865 immunoglobulin binding 3/1192 26/18639 0.115384615384615 1.80423980382034 0.229817049507175 0.664913390631435 GO:0030247 polysaccharide binding 3/1192 26/18639 0.115384615384615 1.80423980382034 0.229817049507175 0.664913390631435 GO:0052742 phosphatidylinositol kinase activity 3/1192 26/18639 0.115384615384615 1.80423980382034 0.229817049507175 0.664913390631435 GO:0005080 protein kinase C binding 5/1192 52/18639 0.0961538461538462 1.50353316985028 0.237648732933429 0.685786343607896 GO:0008320 protein transmembrane transporter activity 3/1192 27/18639 0.111111111111111 1.73741610738255 0.247227705287245 0.695721979810681 GO:0016405 CoA-ligase activity 3/1192 27/18639 0.111111111111111 1.73741610738255 0.247227705287245 0.695721979810681 GO:0004467 long-chain fatty acid-CoA ligase activity 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:0004953 icosanoid receptor activity 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:0031386 protein tag activity 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:0042809 nuclear vitamin D receptor binding 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:0048531 beta-1,3-galactosyltransferase activity 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:0050780 dopamine receptor binding 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:0120283 protein serine/threonine kinase binding 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:0141047 molecular tag activity 2/1192 15/18639 0.133333333333333 2.08489932885906 0.248606324018758 0.695721979810681 GO:1901505 carbohydrate derivative transmembrane transporter activity 5/1192 53/18639 0.0943396226415094 1.47516461947575 0.24979643148326 0.696764204715892 GO:0004532 RNA exonuclease activity 4/1192 40/18639 0.1 1.5636744966443 0.251487350216987 0.696764204715892 GO:0015144 carbohydrate transmembrane transporter activity 4/1192 40/18639 0.1 1.5636744966443 0.251487350216987 0.696764204715892 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/1192 40/18639 0.1 1.5636744966443 0.251487350216987 0.696764204715892 GO:0140789 histone phosphatase activity 11/1192 136/18639 0.0808823529411765 1.264736725227 0.253191825452293 0.699741587257456 GO:0008236 serine-type peptidase activity 15/1192 194/18639 0.077319587628866 1.20902667266311 0.259926874917577 0.716572600579225 GO:0046625 sphingolipid binding 3/1192 28/18639 0.107142857142857 1.67536553211889 0.264829979309846 0.720326939886634 GO:0051019 mitogen-activated protein kinase binding 3/1192 28/18639 0.107142857142857 1.67536553211889 0.264829979309846 0.720326939886634 GO:0051959 dynein light intermediate chain binding 3/1192 28/18639 0.107142857142857 1.67536553211889 0.264829979309846 0.720326939886634 GO:0001530 lipopolysaccharide binding 4/1192 41/18639 0.0975609756097561 1.52553609428712 0.265827223540522 0.720326939886634 GO:0004812 aminoacyl-tRNA ligase activity 4/1192 41/18639 0.0975609756097561 1.52553609428712 0.265827223540522 0.720326939886634 GO:0016875 ligase activity, forming carbon-oxygen bonds 4/1192 41/18639 0.0975609756097561 1.52553609428712 0.265827223540522 0.720326939886634 GO:0140318 protein transporter activity 4/1192 41/18639 0.0975609756097561 1.52553609428712 0.265827223540522 0.720326939886634 GO:0046906 tetrapyrrole binding 12/1192 152/18639 0.0789473684210526 1.23447986577181 0.266551529833373 0.720532237578778 GO:0031267 small GTPase binding 21/1192 283/18639 0.0742049469964664 1.16032383143216 0.270757779380938 0.723704241181969 GO:0003688 DNA replication origin binding 2/1192 16/18639 0.125 1.95459312080537 0.272936162966017 0.723704241181969 GO:0005149 interleukin-1 receptor binding 2/1192 16/18639 0.125 1.95459312080537 0.272936162966017 0.723704241181969 GO:0015562 efflux transmembrane transporter activity 2/1192 16/18639 0.125 1.95459312080537 0.272936162966017 0.723704241181969 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/1192 16/18639 0.125 1.95459312080537 0.272936162966017 0.723704241181969 GO:0030275 LRR domain binding 2/1192 16/18639 0.125 1.95459312080537 0.272936162966017 0.723704241181969 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1192 16/18639 0.125 1.95459312080537 0.272936162966017 0.723704241181969 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1192 16/18639 0.125 1.95459312080537 0.272936162966017 0.723704241181969 GO:0004520 DNA endonuclease activity 4/1192 42/18639 0.0952380952380952 1.4892138063279 0.280310876249461 0.737974842448227 GO:0043175 RNA polymerase core enzyme binding 4/1192 42/18639 0.0952380952380952 1.4892138063279 0.280310876249461 0.737974842448227 GO:0051879 Hsp90 protein binding 4/1192 42/18639 0.0952380952380952 1.4892138063279 0.280310876249461 0.737974842448227 GO:0051020 GTPase binding 23/1192 315/18639 0.073015873015873 1.14173058485139 0.284415826465571 0.747011780622338 GO:0017171 serine hydrolase activity 15/1192 198/18639 0.0757575757575758 1.18460189139719 0.285667362965617 0.748529340223586 GO:0170055 lipid transmembrane transporter activity 5/1192 56/18639 0.0892857142857143 1.39613794343241 0.287086927259525 0.750479002789017 GO:0005200 structural constituent of cytoskeleton 9/1192 112/18639 0.0803571428571429 1.25652414908917 0.288174445142024 0.750574334931534 GO:0061135 endopeptidase regulator activity 14/1192 184/18639 0.0760869565217391 1.18975233440327 0.289143511051815 0.750574334931534 GO:0004725 protein tyrosine phosphatase activity 8/1192 98/18639 0.0816326530612245 1.27646897685249 0.289681773415391 0.750574334931534 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/1192 70/18639 0.0857142857142857 1.34029242569511 0.289825733290394 0.750574334931534 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/1192 17/18639 0.117647058823529 1.83961705487564 0.297229682871084 0.755657157139073 GO:0008429 phosphatidylethanolamine binding 2/1192 17/18639 0.117647058823529 1.83961705487564 0.297229682871084 0.755657157139073 GO:0016805 dipeptidase activity 2/1192 17/18639 0.117647058823529 1.83961705487564 0.297229682871084 0.755657157139073 GO:0019198 transmembrane receptor protein phosphatase activity 2/1192 17/18639 0.117647058823529 1.83961705487564 0.297229682871084 0.755657157139073 GO:0038191 neuropilin binding 2/1192 17/18639 0.117647058823529 1.83961705487564 0.297229682871084 0.755657157139073 GO:0045236 CXCR chemokine receptor binding 2/1192 17/18639 0.117647058823529 1.83961705487564 0.297229682871084 0.755657157139073 GO:0048038 quinone binding 2/1192 17/18639 0.117647058823529 1.83961705487564 0.297229682871084 0.755657157139073 GO:0070403 NAD+ binding 2/1192 17/18639 0.117647058823529 1.83961705487564 0.297229682871084 0.755657157139073 GO:0015932 nucleobase-containing compound transmembrane transporter activity 5/1192 57/18639 0.087719298245614 1.37164429530201 0.299743572381843 0.758553380412543 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1192 30/18639 0.1 1.5636744966443 0.300417180361403 0.758553380412543 GO:0015215 nucleotide transmembrane transporter activity 3/1192 30/18639 0.1 1.5636744966443 0.300417180361403 0.758553380412543 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 10/1192 128/18639 0.078125 1.22162070050336 0.302778137643352 0.762781203904228 GO:0019205 nucleobase-containing compound kinase activity 4/1192 44/18639 0.0909090909090909 1.42152226967663 0.309605962144194 0.77792291277501 GO:0101005 deubiquitinase activity 9/1192 115/18639 0.0782608695652174 1.22374525824336 0.314849376344445 0.77792291277501 GO:0046943 carboxylic acid transmembrane transporter activity 14/1192 188/18639 0.074468085106383 1.16443845494788 0.31680448879188 0.77792291277501 GO:0033218 amide binding 18/1192 247/18639 0.0728744939271255 1.13951987609706 0.317188289956291 0.77792291277501 GO:0042393 histone binding 18/1192 247/18639 0.0728744939271255 1.13951987609706 0.317188289956291 0.77792291277501 GO:0005164 tumor necrosis factor receptor binding 3/1192 31/18639 0.0967741935483871 1.51323338384932 0.318312153084723 0.77792291277501 GO:0016878 acid-thiol ligase activity 3/1192 31/18639 0.0967741935483871 1.51323338384932 0.318312153084723 0.77792291277501 GO:0070325 lipoprotein particle receptor binding 3/1192 31/18639 0.0967741935483871 1.51323338384932 0.318312153084723 0.77792291277501 GO:0072349 modified amino acid transmembrane transporter activity 3/1192 31/18639 0.0967741935483871 1.51323338384932 0.318312153084723 0.77792291277501 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/1192 130/18639 0.0769230769230769 1.20282653588023 0.319636490444284 0.77792291277501 GO:0008409 5'-3' exonuclease activity 2/1192 18/18639 0.111111111111111 1.73741610738255 0.321392094476804 0.77792291277501 GO:0015172 acidic amino acid transmembrane transporter activity 2/1192 18/18639 0.111111111111111 1.73741610738255 0.321392094476804 0.77792291277501 GO:0017075 syntaxin-1 binding 2/1192 18/18639 0.111111111111111 1.73741610738255 0.321392094476804 0.77792291277501 GO:0017128 phospholipid scramblase activity 2/1192 18/18639 0.111111111111111 1.73741610738255 0.321392094476804 0.77792291277501 GO:0031690 adrenergic receptor binding 2/1192 18/18639 0.111111111111111 1.73741610738255 0.321392094476804 0.77792291277501 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/1192 18/18639 0.111111111111111 1.73741610738255 0.321392094476804 0.77792291277501 GO:1901611 phosphatidylglycerol binding 2/1192 18/18639 0.111111111111111 1.73741610738255 0.321392094476804 0.77792291277501 GO:1990381 ubiquitin-specific protease binding 2/1192 18/18639 0.111111111111111 1.73741610738255 0.321392094476804 0.77792291277501 GO:0005342 organic acid transmembrane transporter activity 14/1192 189/18639 0.0740740740740741 1.1582774049217 0.323825555183234 0.779025791477495 GO:0015294 solute:monoatomic cation symporter activity 9/1192 116/18639 0.0775862068965517 1.21319573015506 0.323858143713664 0.779025791477495 GO:0043539 protein serine/threonine kinase activator activity 6/1192 73/18639 0.0821917808219178 1.28521191505011 0.323951319228265 0.779025791477495 GO:0005125 cytokine activity 17/1192 234/18639 0.0726495726495727 1.13600283944244 0.328441617117814 0.787532990070848 GO:0004721 phosphoprotein phosphatase activity 13/1192 175/18639 0.0742857142857143 1.16158676893576 0.328906667320318 0.787532990070848 GO:1990782 protein tyrosine kinase binding 9/1192 117/18639 0.0769230769230769 1.20282653588023 0.332916249170714 0.794925204644123 GO:0008378 galactosyltransferase activity 3/1192 32/18639 0.09375 1.46594484060403 0.336218964441154 0.794925204644123 GO:0030515 snoRNA binding 3/1192 32/18639 0.09375 1.46594484060403 0.336218964441154 0.794925204644123 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1192 32/18639 0.09375 1.46594484060403 0.336218964441154 0.794925204644123 GO:0140142 nucleocytoplasmic carrier activity 3/1192 32/18639 0.09375 1.46594484060403 0.336218964441154 0.794925204644123 GO:0004252 serine-type endopeptidase activity 13/1192 176/18639 0.0738636363636364 1.15498684411226 0.33628699026349 0.794925204644123 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 5/1192 60/18639 0.0833333333333333 1.30306208053691 0.338163508989813 0.796003521723098 GO:0004180 carboxypeptidase activity 4/1192 46/18639 0.0869565217391304 1.35971695360374 0.339172689296686 0.796003521723098 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 7/1192 89/18639 0.0786516853932584 1.22985634567529 0.342456414993502 0.796003521723098 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 7/1192 89/18639 0.0786516853932584 1.22985634567529 0.342456414993502 0.796003521723098 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/1192 19/18639 0.105263157894737 1.64597315436242 0.345340861809661 0.796003521723098 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/1192 19/18639 0.105263157894737 1.64597315436242 0.345340861809661 0.796003521723098 GO:0030506 ankyrin binding 2/1192 19/18639 0.105263157894737 1.64597315436242 0.345340861809661 0.796003521723098 GO:0034987 immunoglobulin receptor binding 2/1192 19/18639 0.105263157894737 1.64597315436242 0.345340861809661 0.796003521723098 GO:0046624 sphingolipid transporter activity 2/1192 19/18639 0.105263157894737 1.64597315436242 0.345340861809661 0.796003521723098 GO:0050145 nucleoside monophosphate kinase activity 2/1192 19/18639 0.105263157894737 1.64597315436242 0.345340861809661 0.796003521723098 GO:0140036 ubiquitin-modified protein reader activity 2/1192 19/18639 0.105263157894737 1.64597315436242 0.345340861809661 0.796003521723098 GO:1990380 K48-linked deubiquitinase activity 2/1192 19/18639 0.105263157894737 1.64597315436242 0.345340861809661 0.796003521723098 GO:0004674 protein serine/threonine kinase activity 30/1192 433/18639 0.069284064665127 1.08337724940713 0.350737518385135 0.806768908749244 GO:0140793 histone H2AXY142 phosphatase activity 7/1192 90/18639 0.0777777777777778 1.21619127516779 0.353023096577254 0.809473278509828 GO:0140359 ABC-type transporter activity 4/1192 47/18639 0.0851063829787234 1.33078680565472 0.353998942126207 0.809473278509828 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/1192 33/18639 0.0909090909090909 1.42152226967663 0.354099021922391 0.809473278509828 GO:0051536 iron-sulfur cluster binding 6/1192 76/18639 0.0789473684210526 1.23447986577181 0.358588036905329 0.818051969202918 GO:0015179 L-amino acid transmembrane transporter activity 5/1192 62/18639 0.0806451612903226 1.26102781987443 0.363994624801179 0.828684483922355 GO:0008013 beta-catenin binding 8/1192 106/18639 0.0754716981132075 1.1801316955806 0.367097341523773 0.834039154259534 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1192 20/18639 0.1 1.5636744966443 0.369004524769509 0.836661279630457 GO:0051540 metal cluster binding 6/1192 77/18639 0.0779220779220779 1.21844765972283 0.370195235177386 0.83765154028936 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/1192 34/18639 0.0882352941176471 1.37971279115673 0.371916305486787 0.839835397145976 GO:0052689 carboxylic ester hydrolase activity 7/1192 92/18639 0.0760869565217391 1.18975233440327 0.3742426601651 0.843374432948126 GO:0005507 copper ion binding 5/1192 63/18639 0.0793650793650794 1.24101150527325 0.376930355935193 0.847711792396759 GO:0016763 pentosyltransferase activity 4/1192 49/18639 0.0816326530612245 1.27646897685249 0.38362710414273 0.861029722631461 GO:0004843 cysteine-type deubiquitinase activity 8/1192 108/18639 0.0740740740740741 1.1582774049217 0.386811309185537 0.863152259171996 GO:0000175 3'-5'-RNA exonuclease activity 3/1192 35/18639 0.0857142857142857 1.34029242569511 0.38963734411712 0.863152259171996 GO:0043015 gamma-tubulin binding 3/1192 35/18639 0.0857142857142857 1.34029242569511 0.38963734411712 0.863152259171996 GO:0004536 DNA nuclease activity 5/1192 64/18639 0.078125 1.22162070050336 0.389860457111332 0.863152259171996 GO:0001846 opsonin binding 2/1192 21/18639 0.0952380952380952 1.4892138063279 0.392321622003357 0.863152259171996 GO:0005123 death receptor binding 2/1192 21/18639 0.0952380952380952 1.4892138063279 0.392321622003357 0.863152259171996 GO:0019200 carbohydrate kinase activity 2/1192 21/18639 0.0952380952380952 1.4892138063279 0.392321622003357 0.863152259171996 GO:0035613 RNA stem-loop binding 2/1192 21/18639 0.0952380952380952 1.4892138063279 0.392321622003357 0.863152259171996 GO:0046332 SMAD binding 6/1192 79/18639 0.0759493670886076 1.18760088352731 0.39343802538206 0.863152259171996 GO:0005506 iron ion binding 11/1192 154/18639 0.0714285714285714 1.11691035474593 0.397227416309976 0.863152259171996 GO:0140101 catalytic activity, acting on a tRNA 10/1192 139/18639 0.0719424460431655 1.12494568103906 0.39738432788926 0.863152259171996 GO:0000287 magnesium ion binding 16/1192 230/18639 0.0695652173913043 1.08777356288299 0.400852979188396 0.863152259171996 GO:0005085 guanyl-nucleotide exchange factor activity 16/1192 230/18639 0.0695652173913043 1.08777356288299 0.400852979188396 0.863152259171996 GO:0000049 tRNA binding 6/1192 80/18639 0.075 1.17275587248322 0.405053128594132 0.863152259171996 GO:0000993 RNA polymerase II complex binding 3/1192 36/18639 0.0833333333333333 1.30306208053691 0.407231175471658 0.863152259171996 GO:0004033 aldo-keto reductase (NADPH) activity 3/1192 36/18639 0.0833333333333333 1.30306208053691 0.407231175471658 0.863152259171996 GO:0045505 dynein intermediate chain binding 3/1192 36/18639 0.0833333333333333 1.30306208053691 0.407231175471658 0.863152259171996 GO:0005048 signal sequence binding 4/1192 51/18639 0.0784313725490196 1.22641136991709 0.413087173450689 0.863152259171996 GO:0030544 Hsp70 protein binding 4/1192 51/18639 0.0784313725490196 1.22641136991709 0.413087173450689 0.863152259171996 GO:0005243 gap junction channel activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0032931 histone H3K56 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0043992 histone H3K9 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0043993 histone H3K18 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0043994 histone H3K23 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0043999 histone H2AK5 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0044012 histone H2AK9 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0044014 histone H2BK5 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0044015 histone H2BK12 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0044016 histone H3K4 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0044017 histone H3K27 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0044018 histone H3K36 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0046972 histone H4K16 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0050321 tau-protein kinase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0140035 ubiquitin-like protein reader activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0140517 protein-RNA adaptor activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0140784 metal ion sensor activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0140908 histone H3K122 acetyltransferase activity 2/1192 22/18639 0.0909090909090909 1.42152226967663 0.415239706068299 0.863152259171996 GO:0008235 metalloexopeptidase activity 5/1192 66/18639 0.0757575757575758 1.18460189139719 0.415649377729089 0.863152259171996 GO:0022829 wide pore channel activity 3/1192 37/18639 0.0810810810810811 1.26784418646835 0.424669291479963 0.879306900129695 GO:0019783 ubiquitin-like protein peptidase activity 9/1192 127/18639 0.0708661417322835 1.10811578502352 0.42501152598528 0.879306900129695 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/1192 23/18639 0.0869565217391304 1.35971695360374 0.437714443499767 0.898629557184506 GO:0008171 O-methyltransferase activity 2/1192 23/18639 0.0869565217391304 1.35971695360374 0.437714443499767 0.898629557184506 GO:0044013 histone H2B acetyltransferase activity 2/1192 23/18639 0.0869565217391304 1.35971695360374 0.437714443499767 0.898629557184506 GO:0003777 microtubule motor activity 5/1192 68/18639 0.0735294117647059 1.14976065929728 0.441257650047748 0.898629557184506 GO:0140223 general transcription initiation factor activity 5/1192 68/18639 0.0735294117647059 1.14976065929728 0.441257650047748 0.898629557184506 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/1192 38/18639 0.0789473684210526 1.23447986577181 0.441925572402056 0.898629557184506 GO:0005246 calcium channel regulator activity 4/1192 53/18639 0.0754716981132075 1.1801316955806 0.442230358759961 0.898629557184506 GO:0051117 ATPase binding 6/1192 84/18639 0.0714285714285714 1.11691035474593 0.451245696316148 0.898629557184506 GO:0000217 DNA secondary structure binding 3/1192 39/18639 0.0769230769230769 1.20282653588023 0.458976211569885 0.898629557184506 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/1192 39/18639 0.0769230769230769 1.20282653588023 0.458976211569885 0.898629557184506 GO:0030215 semaphorin receptor binding 2/1192 24/18639 0.0833333333333333 1.30306208053691 0.459708792967129 0.898629557184506 GO:0043998 histone H2A acetyltransferase activity 2/1192 24/18639 0.0833333333333333 1.30306208053691 0.459708792967129 0.898629557184506 GO:0050699 WW domain binding 2/1192 24/18639 0.0833333333333333 1.30306208053691 0.459708792967129 0.898629557184506 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1192 24/18639 0.0833333333333333 1.30306208053691 0.459708792967129 0.898629557184506 GO:0042578 phosphoric ester hydrolase activity 24/1192 363/18639 0.0661157024793388 1.03383437794664 0.46331896947404 0.898629557184506 GO:0008083 growth factor activity 11/1192 162/18639 0.0679012345679012 1.06175428784489 0.463557090743358 0.898629557184506 GO:0032451 demethylase activity 3/1192 40/18639 0.075 1.17275587248322 0.475799632760661 0.898629557184506 GO:0061791 GTPase motor activity 3/1192 40/18639 0.075 1.17275587248322 0.475799632760661 0.898629557184506 GO:1990606 membrane scission GTPase motor activity 3/1192 40/18639 0.075 1.17275587248322 0.475799632760661 0.898629557184506 GO:0140299 molecular sensor activity 5/1192 71/18639 0.0704225352112676 1.10117922298894 0.47912513118212 0.898629557184506 GO:0008139 nuclear localization sequence binding 2/1192 25/18639 0.08 1.25093959731544 0.481192255222327 0.898629557184506 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1192 25/18639 0.08 1.25093959731544 0.481192255222327 0.898629557184506 GO:0019707 protein-cysteine S-acyltransferase activity 2/1192 25/18639 0.08 1.25093959731544 0.481192255222327 0.898629557184506 GO:0042974 nuclear retinoic acid receptor binding 2/1192 25/18639 0.08 1.25093959731544 0.481192255222327 0.898629557184506 GO:0016791 phosphatase activity 18/1192 273/18639 0.0659340659340659 1.03099417361162 0.481798829801866 0.898629557184506 GO:0001216 DNA-binding transcription activator activity 32/1192 491/18639 0.065173116089613 1.01909539496166 0.482278434185719 0.898629557184506 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0004955 prostaglandin receptor activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0005131 growth hormone receptor binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0005345 purine nucleobase transmembrane transporter activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0005522 profilin binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0008140 cAMP response element binding protein binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0008239 dipeptidyl-peptidase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0015643 toxic substance binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0016783 sulfurtransferase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0031996 thioesterase binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0032356 oxidized DNA binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0033204 ribonuclease P RNA binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0035256 G protein-coupled glutamate receptor binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0042166 acetylcholine binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0043208 glycosphingolipid binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0045322 unmethylated CpG binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0050815 phosphoserine residue binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0051864 histone H3K36 demethylase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0070513 death domain binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0097177 mitochondrial ribosome binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0098505 G-rich strand telomeric DNA binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0099122 RNA polymerase II C-terminal domain binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0140940 histone H2A methyltransferase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0140999 histone H3K4 trimethyltransferase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:1990259 histone H2AQ104 methyltransferase activity 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:1990763 arrestin family protein binding 1/1192 10/18639 0.1 1.5636744966443 0.483690796756377 0.898629557184506 GO:0001727 lipid kinase activity 3/1192 41/18639 0.0731707317073171 1.14415207071534 0.492376401909619 0.898731634528862 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/1192 41/18639 0.0731707317073171 1.14415207071534 0.492376401909619 0.898731634528862 GO:0016877 ligase activity, forming carbon-sulfur bonds 3/1192 41/18639 0.0731707317073171 1.14415207071534 0.492376401909619 0.898731634528862 GO:0015297 antiporter activity 9/1192 135/18639 0.0666666666666667 1.04244966442953 0.498319347614986 0.898731634528862 GO:0008198 ferrous iron binding 2/1192 26/18639 0.0769230769230769 1.20282653588023 0.502140189031922 0.898731634528862 GO:0034237 protein kinase A regulatory subunit binding 2/1192 26/18639 0.0769230769230769 1.20282653588023 0.502140189031922 0.898731634528862 GO:0050750 low-density lipoprotein particle receptor binding 2/1192 26/18639 0.0769230769230769 1.20282653588023 0.502140189031922 0.898731634528862 GO:0070412 R-SMAD binding 2/1192 26/18639 0.0769230769230769 1.20282653588023 0.502140189031922 0.898731634528862 GO:0097602 cullin family protein binding 2/1192 26/18639 0.0769230769230769 1.20282653588023 0.502140189031922 0.898731634528862 GO:0031492 nucleosomal DNA binding 3/1192 42/18639 0.0714285714285714 1.11691035474593 0.508689134652708 0.898731634528862 GO:0048487 beta-tubulin binding 3/1192 42/18639 0.0714285714285714 1.11691035474593 0.508689134652708 0.898731634528862 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0002162 dystroglycan binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0004954 prostanoid receptor activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0008172 S-methyltransferase activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0008432 JUN kinase binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0008526 phosphatidylinositol transfer activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0010854 adenylate cyclase regulator activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0015205 nucleobase transmembrane transporter activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0015217 ADP transmembrane transporter activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0019215 intermediate filament binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0019864 IgG binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0032050 clathrin heavy chain binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0032404 mismatch repair complex binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0032794 GTPase activating protein binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0034713 type I transforming growth factor beta receptor binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0035252 UDP-xylosyltransferase activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0042285 xylosyltransferase activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0048185 activin binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0070990 snRNP binding 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0097493 structural molecule activity conferring elasticity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1192 11/18639 0.0909090909090909 1.42152226967663 0.516727490635082 0.898731634528862 GO:0001671 ATPase activator activity 2/1192 27/18639 0.0740740740740741 1.1582774049217 0.522533187731496 0.898731634528862 GO:0008266 poly(U) RNA binding 2/1192 27/18639 0.0740740740740741 1.1582774049217 0.522533187731496 0.898731634528862 GO:0015252 proton channel activity 2/1192 27/18639 0.0740740740740741 1.1582774049217 0.522533187731496 0.898731634528862 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/1192 122/18639 0.0655737704918033 1.02536032566839 0.523247391597121 0.898731634528862 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 31/1192 484/18639 0.0640495867768595 1.00152705363581 0.523638578059346 0.898731634528862 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1192 43/18639 0.0697674418604651 1.09093569533323 0.524722400995198 0.898731634528862 GO:0015459 potassium channel regulator activity 4/1192 59/18639 0.0677966101694915 1.06011830280969 0.526513402184257 0.898731634528862 GO:0070851 growth factor receptor binding 9/1192 139/18639 0.0647482014388489 1.01245111293516 0.53403449800328 0.898731634528862 GO:0004714 transmembrane receptor protein tyrosine kinase activity 4/1192 60/18639 0.0666666666666667 1.04244966442953 0.53996696598386 0.898731634528862 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/1192 60/18639 0.0666666666666667 1.04244966442953 0.53996696598386 0.898731634528862 GO:0098631 cell adhesion mediator activity 5/1192 76/18639 0.0657894736842105 1.02873322147651 0.540108189832199 0.898731634528862 GO:0019789 SUMO transferase activity 2/1192 28/18639 0.0714285714285714 1.11691035474593 0.542356511456238 0.898731634528862 GO:0036408 histone H3K14 acetyltransferase activity 2/1192 28/18639 0.0714285714285714 1.11691035474593 0.542356511456238 0.898731634528862 GO:0045499 chemorepellent activity 2/1192 28/18639 0.0714285714285714 1.11691035474593 0.542356511456238 0.898731634528862 GO:0141052 histone H3 demethylase activity 2/1192 28/18639 0.0714285714285714 1.11691035474593 0.542356511456238 0.898731634528862 GO:0004713 protein tyrosine kinase activity 9/1192 140/18639 0.0642857142857143 1.00521931927133 0.542822341602529 0.898731634528862 GO:0003720 telomerase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0004875 complement receptor activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0005095 GTPase inhibitor activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0005247 voltage-gated chloride channel activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0010853 cyclase activator activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0015166 polyol transmembrane transporter activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0015368 calcium:monoatomic cation antiporter activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0016208 AMP binding 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0016840 carbon-nitrogen lyase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0017166 vinculin binding 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0035251 UDP-glucosyltransferase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0035497 cAMP response element binding 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0036009 protein-glutamine N-methyltransferase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0097371 MDM2/MDM4 family protein binding 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:1990459 transferrin receptor binding 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:1990817 poly(A) RNA polymerase activity 1/1192 12/18639 0.0833333333333333 1.30306208053691 0.547651950113447 0.898731634528862 GO:0051219 phosphoprotein binding 6/1192 93/18639 0.0645161290322581 1.00882225589955 0.551316334966312 0.903410690483146 GO:0019905 syntaxin binding 4/1192 61/18639 0.0655737704918033 1.02536032566839 0.553223071662818 0.904156817747938 GO:0051539 4 iron, 4 sulfur cluster binding 3/1192 45/18639 0.0666666666666667 1.04244966442953 0.555898003059597 0.904156817747938 GO:0140303 intramembrane lipid transporter activity 3/1192 45/18639 0.0666666666666667 1.04244966442953 0.555898003059597 0.904156817747938 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/1192 29/18639 0.0689655172413793 1.07839620458227 0.561599570485535 0.904156817747938 GO:0010484 histone H3 acetyltransferase activity 2/1192 29/18639 0.0689655172413793 1.07839620458227 0.561599570485535 0.904156817747938 GO:0016417 S-acyltransferase activity 2/1192 29/18639 0.0689655172413793 1.07839620458227 0.561599570485535 0.904156817747938 GO:0035250 UDP-galactosyltransferase activity 2/1192 29/18639 0.0689655172413793 1.07839620458227 0.561599570485535 0.904156817747938 GO:0097472 cyclin-dependent protein kinase activity 2/1192 29/18639 0.0689655172413793 1.07839620458227 0.561599570485535 0.904156817747938 GO:0106222 lncRNA binding 2/1192 29/18639 0.0689655172413793 1.07839620458227 0.561599570485535 0.904156817747938 GO:0015291 secondary active transmembrane transporter activity 18/1192 287/18639 0.0627177700348432 0.980701774898861 0.569214978366676 0.904156817747938 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/1192 46/18639 0.0652173913043478 1.0197877152028 0.571018373787242 0.904156817747938 GO:0003964 RNA-directed DNA polymerase activity 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0004535 poly(A)-specific ribonuclease activity 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0019855 calcium channel inhibitor activity 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0030955 potassium ion binding 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0035325 Toll-like receptor binding 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0043560 insulin receptor substrate binding 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0046974 histone H3K9 methyltransferase activity 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0051011 microtubule minus-end binding 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0071837 HMG box domain binding 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0089720 caspase binding 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0140333 glycerophospholipid flippase activity 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1192 13/18639 0.0769230769230769 1.20282653588023 0.576599116885594 0.904156817747938 GO:0001965 G-protein alpha-subunit binding 2/1192 30/18639 0.0666666666666667 1.04244966442953 0.580255455494401 0.904156817747938 GO:0031210 phosphatidylcholine binding 2/1192 30/18639 0.0666666666666667 1.04244966442953 0.580255455494401 0.904156817747938 GO:0032452 histone demethylase activity 2/1192 30/18639 0.0666666666666667 1.04244966442953 0.580255455494401 0.904156817747938 GO:0033612 receptor serine/threonine kinase binding 2/1192 30/18639 0.0666666666666667 1.04244966442953 0.580255455494401 0.904156817747938 GO:0043995 histone H4K5 acetyltransferase activity 2/1192 30/18639 0.0666666666666667 1.04244966442953 0.580255455494401 0.904156817747938 GO:0043996 histone H4K8 acetyltransferase activity 2/1192 30/18639 0.0666666666666667 1.04244966442953 0.580255455494401 0.904156817747938 GO:0043997 histone H4K12 acetyltransferase activity 2/1192 30/18639 0.0666666666666667 1.04244966442953 0.580255455494401 0.904156817747938 GO:0051015 actin filament binding 13/1192 209/18639 0.062200956937799 0.972620500305064 0.582146201646423 0.905832535054868 GO:0043495 protein-membrane adaptor activity 3/1192 47/18639 0.0638297872340425 0.998090104241039 0.585815153218676 0.906358782347503 GO:0048306 calcium-dependent protein binding 5/1192 80/18639 0.0625 0.977296560402685 0.586385732337652 0.906358782347503 GO:0035591 signaling adaptor activity 8/1192 129/18639 0.062015503875969 0.969720618073982 0.587502046408532 0.906358782347503 GO:0005319 lipid transporter activity 11/1192 178/18639 0.0617977528089888 0.966315700173441 0.591029751495842 0.906358782347503 GO:1901681 sulfur compound binding 17/1192 275/18639 0.0618181818181818 0.96663514338011 0.593570252803646 0.906358782347503 GO:0015293 symporter activity 9/1192 146/18639 0.0616438356164384 0.963908936287579 0.594106608029123 0.906358782347503 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/1192 31/18639 0.0645161290322581 1.00882225589955 0.598320510833 0.906358782347503 GO:0005452 solute:inorganic anion antiporter activity 2/1192 31/18639 0.0645161290322581 1.00882225589955 0.598320510833 0.906358782347503 GO:0140457 protein demethylase activity 2/1192 31/18639 0.0645161290322581 1.00882225589955 0.598320510833 0.906358782347503 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/1192 48/18639 0.0625 0.977296560402685 0.600281222931966 0.906358782347503 GO:0038187 pattern recognition receptor activity 3/1192 48/18639 0.0625 0.977296560402685 0.600281222931966 0.906358782347503 GO:0042626 ATPase-coupled transmembrane transporter activity 6/1192 98/18639 0.0612244897959184 0.957351732639364 0.603174189833608 0.906358782347503 GO:0004705 JUN kinase activity 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0005347 ATP transmembrane transporter activity 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0008174 mRNA methyltransferase activity 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0008559 ABC-type xenobiotic transporter activity 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0016530 metallochaperone activity 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0019992 diacylglycerol binding 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0030983 mismatched DNA binding 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0032036 myosin heavy chain binding 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0046030 inositol trisphosphate phosphatase activity 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:1901474 azole transmembrane transporter activity 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:1901612 cardiolipin binding 1/1192 14/18639 0.0714285714285714 1.11691035474593 0.603695318575295 0.906358782347503 GO:0001221 transcription coregulator binding 7/1192 115/18639 0.0608695652173913 0.951801867522615 0.608566557921666 0.909983103433339 GO:0035401 histone H3Y41 kinase activity 7/1192 115/18639 0.0608695652173913 0.951801867522615 0.608566557921666 0.909983103433339 GO:0140801 histone H2AXY142 kinase activity 7/1192 115/18639 0.0608695652173913 0.951801867522615 0.608566557921666 0.909983103433339 GO:0001217 DNA-binding transcription repressor activity 17/1192 278/18639 0.0611510791366906 0.956203828883202 0.611709447075047 0.913453220027389 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 8/1192 132/18639 0.0606060606060606 0.947681513117755 0.613734236628981 0.915027402875789 GO:0001222 transcription corepressor binding 3/1192 49/18639 0.0612244897959184 0.957351732639364 0.614410839374743 0.915027402875789 GO:0042910 xenobiotic transmembrane transporter activity 2/1192 32/18639 0.0625 0.977296560402685 0.615793947259123 0.915859538694626 GO:0030165 PDZ domain binding 5/1192 83/18639 0.0602409638554217 0.941972588339937 0.619368003747319 0.915969000006782 GO:0106310 protein serine kinase activity 22/1192 361/18639 0.0609418282548476 0.95293182620982 0.624538209982029 0.915969000006782 GO:0008173 RNA methyltransferase activity 4/1192 67/18639 0.0597014925373134 0.933537012921967 0.628199957506435 0.915969000006782 GO:0050840 extracellular matrix binding 4/1192 67/18639 0.0597014925373134 0.933537012921967 0.628199957506435 0.915969000006782 GO:0004559 alpha-mannosidase activity 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0015116 sulfate transmembrane transporter activity 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0016846 carbon-sulfur lyase activity 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0017081 chloride channel regulator activity 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0031005 filamin binding 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0033130 acetylcholine receptor binding 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0047372 monoacylglycerol lipase activity 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0050700 CARD domain binding 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0061578 K63-linked deubiquitinase activity 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0141050 histone H3K deacetylase activity 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0141051 histone H4K deacetylase activity 1/1192 15/18639 0.0666666666666667 1.04244966442953 0.629058818186476 0.915969000006782 GO:0042923 neuropeptide binding 2/1192 33/18639 0.0606060606060606 0.947681513117755 0.632677490829235 0.918829663152 GO:0071889 14-3-3 protein binding 2/1192 33/18639 0.0606060606060606 0.947681513117755 0.632677490829235 0.918829663152 GO:0005548 phospholipid transporter activity 4/1192 68/18639 0.0588235294117647 0.919808527437821 0.639883851722603 0.925078016583975 GO:0005021 vascular endothelial growth factor receptor activity 3/1192 51/18639 0.0588235294117647 0.919808527437821 0.641644065259971 0.925078016583975 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 16/1192 268/18639 0.0597014925373134 0.933537012921967 0.648770194296556 0.925078016583975 GO:0051427 hormone receptor binding 2/1192 34/18639 0.0588235294117647 0.919808527437821 0.648975064913138 0.925078016583975 GO:0003774 cytoskeletal motor activity 9/1192 153/18639 0.0588235294117647 0.919808527437821 0.650228540373262 0.925078016583975 GO:0050660 flavin adenine dinucleotide binding 5/1192 86/18639 0.0581395348837209 0.909113079444358 0.650738899309258 0.925078016583975 GO:0000062 fatty-acyl-CoA binding 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0004707 MAP kinase activity 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0005159 insulin-like growth factor receptor binding 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0015923 mannosidase activity 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0022841 potassium ion leak channel activity 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0022858 alanine transmembrane transporter activity 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0055102 lipase inhibitor activity 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0070411 I-SMAD binding 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0097027 ubiquitin-protein transferase activator activity 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0140327 flippase activity 1/1192 16/18639 0.0625 0.977296560402685 0.652800328534506 0.925078016583975 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/1192 52/18639 0.0576923076923077 0.90211990191017 0.654742250266063 0.92664794910267 GO:0008081 phosphoric diester hydrolase activity 5/1192 87/18639 0.0574712643678161 0.898663503818561 0.660823014910452 0.930460423957928 GO:0010485 histone H4 acetyltransferase activity 2/1192 35/18639 0.0571428571428571 0.89352828379674 0.664692502537139 0.930460423957928 GO:0034061 DNA polymerase activity 2/1192 35/18639 0.0571428571428571 0.89352828379674 0.664692502537139 0.930460423957928 GO:0046982 protein heterodimerization activity 22/1192 369/18639 0.0596205962059621 0.932272057619905 0.665145001762083 0.930460423957928 GO:0005003 ephrin receptor activity 3/1192 53/18639 0.0566037735849057 0.88509877168545 0.66749296375643 0.930460423957928 GO:0005005 transmembrane-ephrin receptor activity 3/1192 53/18639 0.0566037735849057 0.88509877168545 0.66749296375643 0.930460423957928 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1192 53/18639 0.0566037735849057 0.88509877168545 0.66749296375643 0.930460423957928 GO:0038064 collagen receptor activity 3/1192 53/18639 0.0566037735849057 0.88509877168545 0.66749296375643 0.930460423957928 GO:0051018 protein kinase A binding 3/1192 53/18639 0.0566037735849057 0.88509877168545 0.66749296375643 0.930460423957928 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 7/1192 122/18639 0.0573770491803279 0.897190284959842 0.670273555848995 0.930460423957928 GO:0004550 nucleoside diphosphate kinase activity 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0004659 prenyltransferase activity 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0008484 sulfuric ester hydrolase activity 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0008569 minus-end-directed microtubule motor activity 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0016018 cyclosporin A binding 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0030548 acetylcholine receptor regulator activity 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0045125 bioactive lipid receptor activity 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0046965 nuclear retinoid X receptor binding 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0070492 oligosaccharide binding 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:1901567 fatty acid derivative binding 1/1192 17/18639 0.0588235294117647 0.919808527437821 0.67502349388847 0.930460423957928 GO:0000149 SNARE binding 6/1192 106/18639 0.0566037735849057 0.88509877168545 0.678848098182786 0.931318403553253 GO:0004497 monooxygenase activity 6/1192 106/18639 0.0566037735849057 0.88509877168545 0.678848098182786 0.931318403553253 GO:0004190 aspartic-type endopeptidase activity 2/1192 36/18639 0.0555555555555556 0.868708053691275 0.679837286482167 0.931318403553253 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1192 36/18639 0.0555555555555556 0.868708053691275 0.679837286482167 0.931318403553253 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/1192 36/18639 0.0555555555555556 0.868708053691275 0.679837286482167 0.931318403553253 GO:0008017 microtubule binding 16/1192 276/18639 0.0579710144927536 0.906477969069157 0.694074929370126 0.940464663934299 GO:0019213 deacetylase activity 2/1192 37/18639 0.0540540540540541 0.845229457645565 0.694418314768008 0.940464663934299 GO:0070001 aspartic-type peptidase activity 2/1192 37/18639 0.0540540540540541 0.845229457645565 0.694418314768008 0.940464663934299 GO:0000400 four-way junction DNA binding 1/1192 18/18639 0.0555555555555556 0.868708053691275 0.695825340912686 0.940464663934299 GO:0008308 voltage-gated monoatomic anion channel activity 1/1192 18/18639 0.0555555555555556 0.868708053691275 0.695825340912686 0.940464663934299 GO:0008525 phosphatidylcholine transporter activity 1/1192 18/18639 0.0555555555555556 0.868708053691275 0.695825340912686 0.940464663934299 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/1192 18/18639 0.0555555555555556 0.868708053691275 0.695825340912686 0.940464663934299 GO:0016854 racemase and epimerase activity 1/1192 18/18639 0.0555555555555556 0.868708053691275 0.695825340912686 0.940464663934299 GO:0035615 clathrin adaptor activity 1/1192 18/18639 0.0555555555555556 0.868708053691275 0.695825340912686 0.940464663934299 GO:0070628 proteasome binding 1/1192 18/18639 0.0555555555555556 0.868708053691275 0.695825340912686 0.940464663934299 GO:0099602 neurotransmitter receptor regulator activity 1/1192 18/18639 0.0555555555555556 0.868708053691275 0.695825340912686 0.940464663934299 GO:0030170 pyridoxal phosphate binding 3/1192 56/18639 0.0535714285714286 0.837682766059444 0.703662656719513 0.949455955386655 GO:0004620 phospholipase activity 6/1192 109/18639 0.055045871559633 0.860738255033557 0.704679763115162 0.949455955386655 GO:0004866 endopeptidase inhibitor activity 9/1192 161/18639 0.0559006211180124 0.874103755888115 0.708630482952986 0.949455955386655 GO:0070279 vitamin B6 binding 3/1192 57/18639 0.0526315789473684 0.822986577181208 0.715029917497966 0.949455955386655 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0008574 plus-end-directed microtubule motor activity 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0022840 leak channel activity 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0022842 narrow pore channel activity 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0031420 alkali metal ion binding 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0042577 lipid phosphatase activity 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0042800 histone H3K4 methyltransferase activity 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0046527 glucosyltransferase activity 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0120227 acyl-CoA binding 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0141147 intracellularly calcium-gated channel activity 1/1192 19/18639 0.0526315789473684 0.822986577181208 0.715296700862854 0.949455955386655 GO:0016298 lipase activity 7/1192 130/18639 0.0538461538461538 0.841978575116159 0.732933171495695 0.96053764057497 GO:0001614 purinergic nucleotide receptor activity 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0010851 cyclase regulator activity 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0015095 magnesium ion transmembrane transporter activity 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0015464 acetylcholine receptor activity 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0016502 nucleotide receptor activity 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0016505 peptidase activator activity involved in apoptotic process 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0052745 inositol phosphate phosphatase activity 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0061608 nuclear import signal receptor activity 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0140664 ATP-dependent DNA damage sensor activity 1/1192 20/18639 0.05 0.781837248322148 0.733522604867767 0.96053764057497 GO:0004867 serine-type endopeptidase inhibitor activity 5/1192 95/18639 0.0526315789473684 0.822986577181208 0.734540676166058 0.96053764057497 GO:0050997 quaternary ammonium group binding 2/1192 40/18639 0.05 0.781837248322148 0.734884783518204 0.96053764057497 GO:0070888 E-box binding 3/1192 59/18639 0.0508474576271186 0.795088727107269 0.73674655222347 0.961839505899266 GO:0004896 cytokine receptor activity 5/1192 96/18639 0.0520833333333333 0.81441380033557 0.742877183535506 0.964524345709888 GO:0019199 transmembrane receptor protein kinase activity 4/1192 78/18639 0.0512820512820513 0.801884357253485 0.743146214855633 0.964524345709888 GO:0140828 metal cation:monoatomic cation antiporter activity 2/1192 41/18639 0.0487804878048781 0.762768047143559 0.747321110780182 0.964524345709888 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1192 21/18639 0.0476190476190476 0.74460690316395 0.750582654010987 0.964524345709888 GO:0008373 sialyltransferase activity 1/1192 21/18639 0.0476190476190476 0.74460690316395 0.750582654010987 0.964524345709888 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/1192 21/18639 0.0476190476190476 0.74460690316395 0.750582654010987 0.964524345709888 GO:0051428 peptide hormone receptor binding 1/1192 21/18639 0.0476190476190476 0.74460690316395 0.750582654010987 0.964524345709888 GO:0061891 calcium ion sensor activity 1/1192 21/18639 0.0476190476190476 0.74460690316395 0.750582654010987 0.964524345709888 GO:0072542 protein phosphatase activator activity 1/1192 21/18639 0.0476190476190476 0.74460690316395 0.750582654010987 0.964524345709888 GO:0140312 cargo adaptor activity 1/1192 21/18639 0.0476190476190476 0.74460690316395 0.750582654010987 0.964524345709888 GO:0016247 channel regulator activity 9/1192 168/18639 0.0535714285714286 0.837682766059444 0.754272895888235 0.964524345709888 GO:0015026 coreceptor activity 3/1192 61/18639 0.0491803278688525 0.769020244251293 0.757131663977166 0.964524345709888 GO:0030414 peptidase inhibitor activity 9/1192 169/18639 0.0532544378698225 0.832726063301696 0.760366629904471 0.964524345709888 GO:0141108 transporter regulator activity 9/1192 170/18639 0.0529411764705882 0.827827674694039 0.766353461735047 0.964524345709888 GO:0004407 histone deacetylase activity 1/1192 22/18639 0.0454545454545455 0.710761134838316 0.766551365817782 0.964524345709888 GO:0015377 chloride:monoatomic cation symporter activity 1/1192 22/18639 0.0454545454545455 0.710761134838316 0.766551365817782 0.964524345709888 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1192 22/18639 0.0454545454545455 0.710761134838316 0.766551365817782 0.964524345709888 GO:0016881 acid-amino acid ligase activity 1/1192 22/18639 0.0454545454545455 0.710761134838316 0.766551365817782 0.964524345709888 GO:0033558 protein lysine deacetylase activity 1/1192 22/18639 0.0454545454545455 0.710761134838316 0.766551365817782 0.964524345709888 GO:0033691 sialic acid binding 1/1192 22/18639 0.0454545454545455 0.710761134838316 0.766551365817782 0.964524345709888 GO:0034062 5'-3' RNA polymerase activity 1/1192 22/18639 0.0454545454545455 0.710761134838316 0.766551365817782 0.964524345709888 GO:0097747 RNA polymerase activity 1/1192 22/18639 0.0454545454545455 0.710761134838316 0.766551365817782 0.964524345709888 GO:0015101 organic cation transmembrane transporter activity 4/1192 81/18639 0.0493827160493827 0.772184936614467 0.769315745279171 0.964524345709888 GO:0030971 receptor tyrosine kinase binding 4/1192 81/18639 0.0493827160493827 0.772184936614467 0.769315745279171 0.964524345709888 GO:0008200 ion channel inhibitor activity 2/1192 43/18639 0.0465116279069767 0.727290463555486 0.770693212444671 0.964524345709888 GO:0019838 growth factor binding 7/1192 136/18639 0.0514705882352941 0.804832461508093 0.774172042882769 0.964524345709888 GO:0000295 adenine nucleotide transmembrane transporter activity 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0003887 DNA-directed DNA polymerase activity 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0004602 glutathione peroxidase activity 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0005158 insulin receptor binding 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0005212 structural constituent of eye lens 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0005283 amino acid:sodium symporter activity 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0016493 C-C chemokine receptor activity 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0016917 GABA receptor activity 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0031681 G-protein beta-subunit binding 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0043274 phospholipase binding 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0099186 structural constituent of postsynapse 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1192 23/18639 0.0434782608695652 0.679858476801868 0.781498498650419 0.964524345709888 GO:0016248 channel inhibitor activity 2/1192 44/18639 0.0454545454545455 0.710761134838316 0.781656573597836 0.964524345709888 GO:0043014 alpha-tubulin binding 2/1192 44/18639 0.0454545454545455 0.710761134838316 0.781656573597836 0.964524345709888 GO:0015171 amino acid transmembrane transporter activity 5/1192 102/18639 0.0490196078431373 0.766507106198184 0.788854394922785 0.964524345709888 GO:0141110 transporter inhibitor activity 2/1192 45/18639 0.0444444444444444 0.69496644295302 0.792156972227522 0.964524345709888 GO:0140767 enzyme-substrate adaptor activity 7/1192 139/18639 0.0503597122302158 0.787461976727343 0.792948488972239 0.964524345709888 GO:0160215 deacylase activity 3/1192 65/18639 0.0461538461538462 0.721695921528136 0.794062925414942 0.964524345709888 GO:0019957 C-C chemokine binding 1/1192 24/18639 0.0416666666666667 0.651531040268456 0.795489355419257 0.964524345709888 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1192 24/18639 0.0416666666666667 0.651531040268456 0.795489355419257 0.964524345709888 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1192 24/18639 0.0416666666666667 0.651531040268456 0.795489355419257 0.964524345709888 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1192 24/18639 0.0416666666666667 0.651531040268456 0.795489355419257 0.964524345709888 GO:0050431 transforming growth factor beta binding 1/1192 24/18639 0.0416666666666667 0.651531040268456 0.795489355419257 0.964524345709888 GO:0140612 DNA damage sensor activity 1/1192 24/18639 0.0416666666666667 0.651531040268456 0.795489355419257 0.964524345709888 GO:0004677 DNA-dependent protein kinase activity 13/1192 246/18639 0.0528455284552846 0.826332051072189 0.79899883300876 0.964524345709888 GO:0030276 clathrin binding 2/1192 46/18639 0.0434782608695652 0.679858476801868 0.80220872670208 0.964524345709888 GO:0035402 histone H3T11 kinase activity 13/1192 247/18639 0.0526315789473684 0.822986577181208 0.803499195387705 0.964524345709888 GO:0015631 tubulin binding 21/1192 385/18639 0.0545454545454545 0.852913361805979 0.80531580666893 0.964524345709888 GO:0000030 mannosyltransferase activity 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0005537 D-mannose binding 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0008483 transaminase activity 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0015271 outward rectifier potassium channel activity 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0015662 P-type ion transporter activity 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0017025 TBP-class protein binding 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0017056 structural constituent of nuclear pore 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0019211 phosphatase activator activity 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0047617 fatty acyl-CoA hydrolase activity 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0120020 cholesterol transfer activity 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0140358 P-type transmembrane transporter activity 1/1192 25/18639 0.04 0.625469798657718 0.808585067927463 0.964524345709888 GO:0016500 protein-hormone receptor activity 3/1192 67/18639 0.0447761194029851 0.700152759691476 0.810700616364864 0.964524345709888 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/1192 67/18639 0.0447761194029851 0.700152759691476 0.810700616364864 0.964524345709888 GO:0042054 histone methyltransferase activity 3/1192 67/18639 0.0447761194029851 0.700152759691476 0.810700616364864 0.964524345709888 GO:0140938 histone H3 methyltransferase activity 2/1192 47/18639 0.0425531914893617 0.66539340282736 0.811826218856898 0.964524345709888 GO:0141003 histone H2AX kinase activity 19/1192 354/18639 0.0536723163841808 0.839260323057673 0.816777200522041 0.964524345709888 GO:0001637 G protein-coupled chemoattractant receptor activity 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0004529 DNA exonuclease activity 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0004950 chemokine receptor activity 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0005112 Notch binding 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0005160 transforming growth factor beta receptor binding 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0015216 purine nucleotide transmembrane transporter activity 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0016289 acyl-CoA hydrolase activity 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0030507 spectrin binding 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0043548 phosphatidylinositol 3-kinase binding 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0050681 nuclear androgen receptor binding 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0051139 metal cation:proton antiporter activity 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0120014 phospholipid transfer activity 1/1192 26/18639 0.0384615384615385 0.601413267940114 0.820842863083285 0.964524345709888 GO:0019955 cytokine binding 7/1192 144/18639 0.0486111111111111 0.760119546979866 0.821584319816927 0.964524345709888 GO:0140996 histone H3 kinase activity 19/1192 357/18639 0.0532212885154062 0.832207715300885 0.827345140869433 0.964524345709888 GO:0005004 GPI-linked ephrin receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0005008 hepatocyte growth factor receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0005009 insulin receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0005011 macrophage colony-stimulating factor receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0005020 stem cell factor receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0008288 boss receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0036332 placental growth factor receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0038062 protein tyrosine kinase collagen receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0060175 brain-derived neurotrophic factor receptor activity 2/1192 49/18639 0.0408163265306122 0.638234488426243 0.829815869417953 0.964524345709888 GO:0016829 lyase activity 10/1192 200/18639 0.05 0.781837248322148 0.830072988805133 0.964524345709888 GO:0004364 glutathione transferase activity 1/1192 27/18639 0.037037037037037 0.57913870246085 0.832316312135277 0.964524345709888 GO:0008395 steroid hydroxylase activity 1/1192 27/18639 0.037037037037037 0.57913870246085 0.832316312135277 0.964524345709888 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/1192 27/18639 0.037037037037037 0.57913870246085 0.832316312135277 0.964524345709888 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/1192 27/18639 0.037037037037037 0.57913870246085 0.832316312135277 0.964524345709888 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/1192 27/18639 0.037037037037037 0.57913870246085 0.832316312135277 0.964524345709888 GO:0015103 inorganic anion transmembrane transporter activity 8/1192 165/18639 0.0484848484848485 0.758145210494204 0.835434333842326 0.964524345709888 GO:0035173 histone kinase activity 19/1192 360/18639 0.0527777777777778 0.825272651006711 0.837460966739817 0.964524345709888 GO:0005006 epidermal growth factor receptor activity 2/1192 50/18639 0.04 0.625469798657718 0.838216549718186 0.964524345709888 GO:0005007 fibroblast growth factor receptor activity 2/1192 50/18639 0.04 0.625469798657718 0.838216549718186 0.964524345709888 GO:0005017 platelet-derived growth factor receptor activity 2/1192 50/18639 0.04 0.625469798657718 0.838216549718186 0.964524345709888 GO:0005019 platelet-derived growth factor beta-receptor activity 2/1192 50/18639 0.04 0.625469798657718 0.838216549718186 0.964524345709888 GO:0005242 inward rectifier potassium channel activity 1/1192 28/18639 0.0357142857142857 0.558455177372963 0.843055564012278 0.964524345709888 GO:0016866 intramolecular transferase activity 1/1192 28/18639 0.0357142857142857 0.558455177372963 0.843055564012278 0.964524345709888 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/1192 28/18639 0.0357142857142857 0.558455177372963 0.843055564012278 0.964524345709888 GO:0005010 insulin-like growth factor receptor activity 2/1192 51/18639 0.0392156862745098 0.613205684958547 0.846239916430766 0.964524345709888 GO:0005030 neurotrophin receptor activity 2/1192 51/18639 0.0392156862745098 0.613205684958547 0.846239916430766 0.964524345709888 GO:0016597 amino acid binding 2/1192 51/18639 0.0392156862745098 0.613205684958547 0.846239916430766 0.964524345709888 GO:0043178 alcohol binding 4/1192 92/18639 0.0434782608695652 0.679858476801868 0.847662637726259 0.964524345709888 GO:0005201 extracellular matrix structural constituent 8/1192 168/18639 0.0476190476190476 0.74460690316395 0.84933823458239 0.964524345709888 GO:0031406 carboxylic acid binding 9/1192 187/18639 0.0481283422459893 0.752570613358217 0.852180476629222 0.964524345709888 GO:0005416 amino acid:monoatomic cation symporter activity 1/1192 29/18639 0.0344827586206897 0.539198102291136 0.85310756378109 0.964524345709888 GO:0043236 laminin binding 1/1192 29/18639 0.0344827586206897 0.539198102291136 0.85310756378109 0.964524345709888 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 12/1192 243/18639 0.0493827160493827 0.772184936614467 0.85866970691087 0.964524345709888 GO:0035064 methylated histone binding 3/1192 74/18639 0.0405405405405405 0.633922093234174 0.860223133282095 0.964524345709888 GO:0043177 organic acid binding 9/1192 189/18639 0.0476190476190476 0.74460690316395 0.8603905979339 0.964524345709888 GO:0017046 peptide hormone binding 2/1192 53/18639 0.0377358490566038 0.5900658477903 0.8612098959919 0.964524345709888 GO:0003730 mRNA 3'-UTR binding 13/1192 262/18639 0.049618320610687 0.775869025052513 0.862409003766486 0.964524345709888 GO:0016769 transferase activity, transferring nitrogenous groups 1/1192 30/18639 0.0333333333333333 0.521224832214765 0.862516257170286 0.964524345709888 GO:0031624 ubiquitin conjugating enzyme binding 1/1192 30/18639 0.0333333333333333 0.521224832214765 0.862516257170286 0.964524345709888 GO:0051721 protein phosphatase 2A binding 1/1192 30/18639 0.0333333333333333 0.521224832214765 0.862516257170286 0.964524345709888 GO:0070566 adenylyltransferase activity 1/1192 30/18639 0.0333333333333333 0.521224832214765 0.862516257170286 0.964524345709888 GO:0098918 structural constituent of synapse 1/1192 30/18639 0.0333333333333333 0.521224832214765 0.862516257170286 0.964524345709888 GO:0004676 3-phosphoinositide-dependent protein kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0004711 ribosomal protein S6 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0035175 histone H3S10 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0035979 histone H2AXS139 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0044022 histone H3S28 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0044023 histone H4S1 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0044024 histone H2AS1 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0044025 histone H2BS14 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0072354 histone H3T3 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0072371 histone H2AS121 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0072518 Rho-dependent protein serine/threonine kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0140823 histone H2BS36 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0140855 histone H3S57 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0140995 histone H2A kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0140997 histone H4 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0140998 histone H2B kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:1990244 histone H2AT120 kinase activity 12/1192 245/18639 0.0489795918367347 0.765881386111492 0.865725402752483 0.964524345709888 GO:0015485 cholesterol binding 2/1192 54/18639 0.037037037037037 0.57913870246085 0.868183506718684 0.964524345709888 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/1192 54/18639 0.037037037037037 0.57913870246085 0.868183506718684 0.964524345709888 GO:0051287 NAD binding 2/1192 54/18639 0.037037037037037 0.57913870246085 0.868183506718684 0.964524345709888 GO:0140857 histone H3T45 kinase activity 12/1192 246/18639 0.0487804878048781 0.762768047143559 0.869147278123956 0.964524345709888 GO:0008327 methyl-CpG binding 1/1192 31/18639 0.032258064516129 0.504411127949773 0.871322782048196 0.964524345709888 GO:0070273 phosphatidylinositol-4-phosphate binding 1/1192 31/18639 0.032258064516129 0.504411127949773 0.871322782048196 0.964524345709888 GO:0140034 methylation-dependent protein binding 3/1192 76/18639 0.0394736842105263 0.617239932885906 0.872110917154188 0.964524345709888 GO:0035403 histone H3T6 kinase activity 12/1192 247/18639 0.048582995951417 0.759679917398038 0.872499520646658 0.964524345709888 GO:0016779 nucleotidyltransferase activity 6/1192 136/18639 0.0441176470588235 0.689856395578366 0.873925405905867 0.965140284255882 GO:0098632 cell-cell adhesion mediator activity 2/1192 55/18639 0.0363636363636364 0.568608907870653 0.874833748863638 0.96518400693893 GO:0004679 AMP-activated protein kinase activity 12/1192 248/18639 0.0483870967741935 0.756616691924659 0.875782912831794 0.965272635075519 GO:0015106 bicarbonate transmembrane transporter activity 1/1192 32/18639 0.03125 0.488648280201342 0.879565647686553 0.967522212455208 GO:0120015 sterol transfer activity 1/1192 32/18639 0.03125 0.488648280201342 0.879565647686553 0.967522212455208 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/1192 56/18639 0.0357142857142857 0.558455177372963 0.88117341894305 0.968332016266794 GO:0019956 chemokine binding 1/1192 33/18639 0.0303030303030303 0.473840756558877 0.887280902588344 0.974080121319813 GO:0015370 solute:sodium symporter activity 3/1192 79/18639 0.0379746835443038 0.593800441763656 0.888265656889234 0.974198563478716 GO:0099106 ion channel regulator activity 7/1192 160/18639 0.04375 0.684107592281879 0.892746532428986 0.976220084457154 GO:0015108 chloride transmembrane transporter activity 5/1192 121/18639 0.0413223140495868 0.646146486216651 0.893034215683483 0.976220084457154 GO:0008175 tRNA methyltransferase activity 1/1192 34/18639 0.0294117647058824 0.45990426371891 0.894502291608805 0.976220084457154 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1192 34/18639 0.0294117647058824 0.45990426371891 0.894502291608805 0.976220084457154 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/1192 34/18639 0.0294117647058824 0.45990426371891 0.894502291608805 0.976220084457154 GO:0001786 phosphatidylserine binding 2/1192 59/18639 0.0338983050847458 0.530059151404846 0.898452200712279 0.979568591748127 GO:0005343 organic acid:sodium symporter activity 1/1192 35/18639 0.0285714285714286 0.44676414189837 0.901261403052089 0.979746985118269 GO:0061631 ubiquitin conjugating enzyme activity 1/1192 35/18639 0.0285714285714286 0.44676414189837 0.901261403052089 0.979746985118269 GO:0140566 histone reader activity 1/1192 35/18639 0.0285714285714286 0.44676414189837 0.901261403052089 0.979746985118269 GO:0005254 chloride channel activity 3/1192 83/18639 0.036144578313253 0.565183553003962 0.906957525814281 0.980865810205383 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1192 36/18639 0.0277777777777778 0.434354026845638 0.907587806382659 0.980865810205383 GO:0055106 ubiquitin-protein transferase regulator activity 1/1192 36/18639 0.0277777777777778 0.434354026845638 0.907587806382659 0.980865810205383 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/1192 36/18639 0.0277777777777778 0.434354026845638 0.907587806382659 0.980865810205383 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/1192 36/18639 0.0277777777777778 0.434354026845638 0.907587806382659 0.980865810205383 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/1192 36/18639 0.0277777777777778 0.434354026845638 0.907587806382659 0.980865810205383 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/1192 61/18639 0.0327868852459016 0.512680162834195 0.908638565205804 0.981047080606072 GO:0030280 structural constituent of skin epidermis 1/1192 37/18639 0.027027027027027 0.422614728822783 0.913509181149732 0.985348252677041 GO:0000146 microfilament motor activity 1/1192 38/18639 0.0263157894736842 0.411493288590604 0.919051437685025 0.989420963459766 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 3/1192 86/18639 0.0348837209302326 0.545467847666615 0.919066097471178 0.989420963459766 GO:0019842 vitamin binding 6/1192 150/18639 0.04 0.625469798657718 0.923515347839033 0.991906094835927 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/1192 39/18639 0.0256410256410256 0.400942178626742 0.924238830098307 0.991906094835927 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/1192 39/18639 0.0256410256410256 0.400942178626742 0.924238830098307 0.991906094835927 GO:0120013 lipid transfer activity 2/1192 65/18639 0.0307692307692308 0.481130614352091 0.926203975098217 0.991906094835927 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/1192 40/18639 0.025 0.390918624161074 0.929094062061899 0.991906094835927 GO:0030331 nuclear estrogen receptor binding 1/1192 40/18639 0.025 0.390918624161074 0.929094062061899 0.991906094835927 GO:0071855 neuropeptide receptor binding 1/1192 40/18639 0.025 0.390918624161074 0.929094062061899 0.991906094835927 GO:0071949 FAD binding 1/1192 40/18639 0.025 0.390918624161074 0.929094062061899 0.991906094835927 GO:0005179 hormone activity 5/1192 132/18639 0.0378787878787879 0.592300945698597 0.93022450334668 0.991906094835927 GO:1902936 phosphatidylinositol bisphosphate binding 4/1192 111/18639 0.036036036036036 0.563486305097043 0.930302565993732 0.991906094835927 GO:0017080 sodium channel regulator activity 1/1192 41/18639 0.024390243902439 0.381384023571779 0.933638385843942 0.993555791832011 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/1192 41/18639 0.024390243902439 0.381384023571779 0.933638385843942 0.993555791832011 GO:0032934 sterol binding 2/1192 68/18639 0.0294117647058824 0.45990426371891 0.937231300327844 0.99484849093091 GO:0008307 structural constituent of muscle 1/1192 42/18639 0.0238095238095238 0.372303451581975 0.937891695020951 0.99484849093091 GO:0016859 cis-trans isomerase activity 1/1192 42/18639 0.0238095238095238 0.372303451581975 0.937891695020951 0.99484849093091 GO:0016279 protein-lysine N-methyltransferase activity 2/1192 69/18639 0.0289855072463768 0.453238984534578 0.940546050591438 0.99484849093091 GO:0098960 postsynaptic neurotransmitter receptor activity 2/1192 69/18639 0.0289855072463768 0.453238984534578 0.940546050591438 0.99484849093091 GO:0005245 voltage-gated calcium channel activity 1/1192 43/18639 0.0232558139534884 0.363645231777743 0.941872611272768 0.99484849093091 GO:0005543 phospholipid binding 24/1192 497/18639 0.0482897384305835 0.755094324335273 0.943028859280359 0.99484849093091 GO:0016278 lysine N-methyltransferase activity 2/1192 70/18639 0.0285714285714286 0.44676414189837 0.943694008090177 0.99484849093091 GO:0042562 hormone binding 3/1192 94/18639 0.0319148936170213 0.49904505212052 0.944647659154298 0.99484849093091 GO:0001223 transcription coactivator binding 1/1192 44/18639 0.0227272727272727 0.355380567419158 0.945598565637301 0.99484849093091 GO:0016790 thiolester hydrolase activity 1/1192 44/18639 0.0227272727272727 0.355380567419158 0.945598565637301 0.99484849093091 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/1192 44/18639 0.0227272727272727 0.355380567419158 0.945598565637301 0.99484849093091 GO:0008276 protein methyltransferase activity 3/1192 95/18639 0.0315789473684211 0.493791946308725 0.947255665937648 0.99564904906029 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/1192 45/18639 0.0222222222222222 0.34748322147651 0.949085874578432 0.996629873966577 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/1192 46/18639 0.0217391304347826 0.339929238400934 0.952349811197907 0.996873489166253 GO:0008170 N-methyltransferase activity 3/1192 98/18639 0.0306122448979592 0.478675866319682 0.954409187419169 0.996873489166253 GO:0003684 damaged DNA binding 2/1192 74/18639 0.027027027027027 0.422614728822783 0.954768404408032 0.996873489166253 GO:0005504 fatty acid binding 1/1192 47/18639 0.0212765957446809 0.33269670141368 0.955404671900972 0.996873489166253 GO:0099095 ligand-gated monoatomic anion channel activity 1/1192 47/18639 0.0212765957446809 0.33269670141368 0.955404671900972 0.996873489166253 GO:0035091 phosphatidylinositol binding 12/1192 284/18639 0.0422535211267606 0.660707533793364 0.955418613708548 0.996873489166253 GO:1901981 phosphatidylinositol phosphate binding 7/1192 185/18639 0.0378378378378378 0.591660620351896 0.955598799245778 0.996873489166253 GO:0008188 neuropeptide receptor activity 1/1192 48/18639 0.0208333333333333 0.325765520134228 0.958263838805772 0.99871587702928 GO:0017022 myosin binding 2/1192 76/18639 0.0263157894736842 0.411493288590604 0.959492157395253 0.998753825507151 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 6/1192 167/18639 0.0359281437125748 0.561799220351244 0.960098186896163 0.998753825507151 GO:0003779 actin binding 20/1192 443/18639 0.0451467268623025 0.705947854015483 0.964182121937306 0.99999999999932 GO:0005253 monoatomic anion channel activity 3/1192 103/18639 0.029126213592233 0.455439173779892 0.96435047417433 0.99999999999932 GO:0008509 monoatomic anion transmembrane transporter activity 5/1192 149/18639 0.0335570469798658 0.524722985451106 0.965360203617931 0.99999999999932 GO:0033293 monocarboxylic acid binding 2/1192 79/18639 0.0253164556962025 0.395866961175771 0.965701173438505 0.99999999999932 GO:0030159 signaling receptor complex adaptor activity 1/1192 52/18639 0.0192307692307692 0.300706633970057 0.967982379972961 0.99999999999932 GO:0016741 transferase activity, transferring one-carbon groups 8/1192 215/18639 0.0372093023255814 0.581832370844389 0.968665430094065 0.99999999999932 GO:0005544 calcium-dependent phospholipid binding 1/1192 53/18639 0.0188679245283019 0.29503292389515 0.970035696972597 0.99999999999932 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/1192 53/18639 0.0188679245283019 0.29503292389515 0.970035696972597 0.99999999999932 GO:0050661 NADP binding 1/1192 54/18639 0.0185185185185185 0.289569351230425 0.97195743641135 0.99999999999932 GO:0005496 steroid binding 3/1192 108/18639 0.0277777777777778 0.434354026845638 0.972223102575897 0.99999999999932 GO:0008168 methyltransferase activity 7/1192 204/18639 0.0343137254901961 0.536554974338729 0.978597217791179 0.99999999999932 GO:0005516 calmodulin binding 7/1192 207/18639 0.0338164251207729 0.528778815290341 0.981004880590932 0.99999999999932 GO:0016836 hydro-lyase activity 1/1192 61/18639 0.0163934426229508 0.256340081417098 0.982369379607247 0.99999999999932 GO:0072341 modified amino acid binding 2/1192 91/18639 0.021978021978022 0.343664724537208 0.982545909462072 0.99999999999932 GO:0022824 transmitter-gated monoatomic ion channel activity 1/1192 63/18639 0.0158730158730159 0.24820230105465 0.984559284346485 0.99999999999932 GO:0022835 transmitter-gated channel activity 1/1192 63/18639 0.0158730158730159 0.24820230105465 0.984559284346485 0.99999999999932 GO:0008528 G protein-coupled peptide receptor activity 3/1192 122/18639 0.0245901639344262 0.384510122125646 0.986418275735272 0.99999999999932 GO:0030594 neurotransmitter receptor activity 2/1192 97/18639 0.0206185567010309 0.322407112710164 0.987614092541363 0.99999999999932 GO:0001653 peptide receptor activity 3/1192 128/18639 0.0234375 0.366486210151007 0.99007188562852 0.99999999999932 GO:0016782 transferase activity, transferring sulphur-containing groups 1/1192 70/18639 0.0142857142857143 0.223382070949185 0.990294535426125 0.99999999999932 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/1192 130/18639 0.0230769230769231 0.360847960764068 0.991063807109239 0.99999999999932 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/1192 73/18639 0.0136986301369863 0.214201985841684 0.992046278686135 0.99999999999932 GO:0015081 sodium ion transmembrane transporter activity 4/1192 164/18639 0.024390243902439 0.381384023571779 0.994171452052192 0.99999999999932 GO:0016835 carbon-oxygen lyase activity 1/1192 79/18639 0.0126582278481013 0.197933480587885 0.994658845777216 0.99999999999932 GO:0015085 calcium ion transmembrane transporter activity 3/1192 147/18639 0.0204081632653061 0.319117244213121 0.996400905073109 0.99999999999932 GO:0022832 voltage-gated channel activity 4/1192 175/18639 0.0228571428571429 0.357411313518696 0.996651729393152 0.99999999999932 GO:0046873 metal ion transmembrane transporter activity 16/1192 450/18639 0.0355555555555556 0.555973154362416 0.997357887690034 0.99999999999932 GO:0005262 calcium channel activity 2/1192 131/18639 0.0152671755725191 0.238728930785389 0.998312723084533 0.99999999999932 GO:0005249 voltage-gated potassium channel activity 1/1192 98/18639 0.0102040816326531 0.159558622106561 0.998487744251574 0.99999999999932 GO:0030527 structural constituent of chromatin 1/1192 98/18639 0.0102040816326531 0.159558622106561 0.998487744251574 0.99999999999932 GO:0099094 ligand-gated monoatomic cation channel activity 2/1192 136/18639 0.0147058823529412 0.229952131859455 0.998748604140711 0.99999999999932 GO:0005244 voltage-gated monoatomic ion channel activity 3/1192 173/18639 0.0173410404624277 0.271157427163751 0.999141924257833 0.99999999999932 GO:0022843 voltage-gated monoatomic cation channel activity 2/1192 143/18639 0.013986013986014 0.218695733796405 0.999178095585749 0.99999999999932 GO:0015276 ligand-gated monoatomic ion channel activity 3/1192 186/18639 0.0161290322580645 0.252205563974886 0.999587627043774 0.99999999999932 GO:0022834 ligand-gated channel activity 3/1192 188/18639 0.0159574468085106 0.24952252606026 0.999631892430745 0.99999999999932 GO:0015079 potassium ion transmembrane transporter activity 2/1192 160/18639 0.0125 0.195459312080537 0.99970645788114 0.99999999999932 GO:0005267 potassium channel activity 1/1192 124/18639 0.00806451612903226 0.126102781987443 0.999731604440211 0.99999999999932 GO:0045182 translation regulator activity 8/1192 356/18639 0.0224719101123595 0.351387527335797 0.999929674157799 0.99999999999932 GO:0005261 monoatomic cation channel activity 7/1192 341/18639 0.0205278592375367 0.320988899604401 0.999958927546867 0.99999999999932 GO:0022836 gated channel activity 6/1192 318/18639 0.0188679245283019 0.29503292389515 0.999966421080462 0.99999999999932 GO:0005216 monoatomic ion channel activity 10/1192 448/18639 0.0223214285714286 0.349034485858102 0.999990271900915 0.99999999999932 GO:0030371 translation repressor activity 5/1192 329/18639 0.0151975683890578 0.237640501009771 0.999996022834039 0.99999999999932 GO:0004984 olfactory receptor activity 1/1192 419/18639 0.00238663484486874 0.0373192003972386 0.99999999999932 0.99999999999932