category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	17/399	88/9376	4.5395306447938	SERPINE2/CFD/C1QA/THBD/C2/C1R/C1QC/C1QB/F13A1/VSIG4/MASP1/SERPING1/C4BPB/TFPI/C3AR1/CR1/ITGB2	7.03286665100688
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/399	82/9376	4.5851213399352	HSPA1A/HLA-E/HSPA1B/HLA-A/HLA-B/B2M/HLA-G/CANX/CTSB/HSP90AA1/TAPBP/HLA-F/HSPA2/CTSL/PSME1/TNF	6.87410125072121
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	28/399	238/9376	2.76455845496093	RPS9/CFD/PLCG2/JUN/RPL7A/C1QA/RPS18/RPS25/C2/RPL36A/C1R/RPS17/C1QC/RPL17/C1QB/F13A1/FOS/MASP1/MX1/RPS10/IL6ST/HBEGF/TLR7/ADAR/NFKBIB/IRF9/TNF/C3AR1	5.8130682913397
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/399	78/9376	4.21772379667116	JUN/C1QA/C2/CD14/C1R/C1QC/C1QB/FOS/CFL2/SERPING1/C4BPB/TNF/ITGA5/ITGB2	6.01599914995173
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	20/399	155/9376	3.03209636995715	HLA-E/HLA-A/HLA-B/HLA-G/CANX/ATP6V0C/TUBB/CD14/C1R/TUBB4A/MRC1/CD209/OLR1/HLA-F/COLEC12/CTSL/ITGA5/NCF4/SCARB1/ITGB2	5.37808437653918
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/399	205/9376	2.63644477046274	HLA-E/HLA-A/HLA-B/HLA-G/JUN/YWHAE/CDKN1A/ACTN4/IRF7/DDX3X/CDC42/IL6ST/MRPS18B/EGR2/GTF2H1/ATF6B/HLA-F/CHD4/ATF4/EGR3/IRF9/PXN/GTF2H2	4.99432051140198
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/399	224/9376	2.41281775868242	HLA-E/HLA-A/HLA-B/B2M/HLA-G/CANX/JUN/EGR1/PTEN/CDKN1A/ZFP36/FOS/CDKN2C/EGR2/GPS2/ATF6B/HLA-F/ATF4/SLC2A1/TNF/MSX2/ITGB2/SPI1	4.51189123749906
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/399	70/9376	3.69266022198353	HGF/EGLN3/JUN/CDKN1A/EGLN1/CDC42/VEGFA/PDGFB/EGLN2/EPAS1/SLC2A1	4.76711384988297
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/399	110/9376	2.99074960127592	EGLN3/PLCG2/LDHA/FLT1/CDKN1A/EGLN1/VEGFA/EGLN2/EPAS1/ENO2/SLC2A1/MKNK2/PDK1/PFKFB3	4.42765022800426
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	20/399	196/9376	2.39783131297632	HLA-E/HLA-A/HLA-B/HLA-G/PLCG2/JUN/UBC/CDKN1A/ZFP36/FOS/IRF7/VEGFA/IL6ST/PDGFB/HLA-F/CCR1/GNG10/CD200R1/IRF9/TCF7L2	4.16934596347461
NA	NA	hsa04518	Integrin signaling	17/399	154/9376	2.59401751131074	SPP1/FN1/HGF/PDGFD/FLT1/ITGA11/FBN1/ACTN4/TNXB/CDC42/VEGFA/PDGFB/LAMA3/ITGA5/PXN/COL4A5/ITGB2	4.20481955242769
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/399	201/9376	2.33818376787741	FLT1/CD14/CDKN1A/CSF1R/KMT2A/FUS/CDKN2C/GADD45B/PROM1/TAF15/NUPR1/MAF/IGFBP3/HPGD/CEBPA/RXRB/ZBTB16/EWSR1/MLLT1/SPI1	4.0431255102943
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/399	56/9376	3.7765843179377	HSPA1A/HSPA1B/EEF1G/CD14/IL18/HSF1/TNF/CR1/ITGB2	4.39342682346349
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/399	99/9376	2.84833295359611	CFD/C1QA/C2/C1R/C1QC/C1QB/MASP1/KRT19/KRT18/DEFB1/C3AR1/ITGB2	3.89762900923895
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/399	142/9376	2.4822619930107	SQSTM1/JUNB/PLCG2/JUN/CTSK/FOSB/CSF1R/SOCS3/FOS/IRF9/TNF/LILRB4/NCF4/LILRB5/SPI1	3.752154247015
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	19/399	203/9376	2.19939010086793	SPP1/FN1/HGF/PDGFD/JUN/FLT1/ITGA11/PTEN/ACTN4/TNXB/CDC42/ZYX/VEGFA/PDGFB/ARHGAP5/LAMA3/ITGA5/PXN/COL4A5	3.64216197339845
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/399	50/9376	3.75979949874687	HGF/HBA2/HBA1/IL18/TNF/LRP1/CR1/ITGB2	4.1249748166956
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	26/399	333/9376	1.83473699263173	SPP1/FN1/HLA-E/HLA-A/HLA-B/HLA-G/ATP6V0C/ITGA11/PTEN/CDKN1A/HES1/MX1/TNXB/CDC42/VEGFA/HLA-F/LAMA3/CHD4/PPP2CA/IRF9/TNF/MAML1/ITGA5/PXN/TCF7L2/COL4A5	3.26980599032812
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/399	95/9376	2.72090753198786	ATP6V0C/JUN/CTSK/FLT1/CCL3/FOS/IL18/VEGFA/CTSL/TNF/ITGB2	3.55409003216191
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/399	44/9376	3.7384370015949	HLA-E/HLA-A/HLA-B/HLA-G/HLA-F/TNF/CPE	3.83838206141626
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	18/399	205/9376	2.06330460297084	HLA-E/HLA-A/HLA-B/B2M/HLA-G/PLCG2/JUN/CDKN1A/HES1/IRF7/GADD45B/BCL2L11/CD44/TAPBP/HLA-F/NFKBIB/IRF9/TNF	3.24513487062796
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	27/399	362/9376	1.75266896523076	SPP1/FN1/HGF/CSH1/PDGFD/FLT1/ITGA11/YWHAE/DDIT4/PTEN/CDKN1A/CSF1R/TNXB/BCL2L11/HSP90AA1/VEGFA/MCL1/PDGFB/ATF6B/LAMA3/GNG10/ATF4/PCK2/PPP2CA/ITGA5/COL4A5/EIF4B	3.07897378328765
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	13/399	133/9376	2.29686999453521	GABARAP/PTEN/CDKN1A/DEPP1/TNFSF10/PLK2/GADD45B/BCL2L11/GABARAPL1/PLK3/PCK2/SOD2/SIRT1	3.17557416148493
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	18/399	216/9376	1.95822890559733	HSPA1A/HSPA1B/JUN/CD14/CCL3/TNFSF10/FOS/IRF7/IL18/HSP90AA1/CDC42/OLR1/HSPA2/ATF4/RXRB/TNF/SOD2/NCF4	3.00368841623716
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/399	38/9376	3.71032845271072	GFPT2/HEXB/UGP2/GCK/PGM3/RENBP	3.52933807392509
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/399	137/9376	2.22980809688455	JUN/CTSK/CTSB/CTSD/TNFSF10/FOS/GADD45B/BCL2L11/MCL1/CTSL/ATF4/TNF/PTPN13	3.05697313084574
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/399	39/9376	3.61519182571814	HLA-E/HLA-A/HLA-B/HLA-G/HLA-F/TNF	3.45015532769607
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/399	109/9376	2.37143317008117	SPP1/JUN/CTSK/CD14/CCL3/CCL4/FOS/IRF7/TLR7/IRF9/TNF	3.0361609498238
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/399	275/9376	1.79444976076555	HSPA1A/MT-ND1/HSPA1B/MT-CO3/MT-ND2/EGR1/C1QA/TUBB/MT-ATP6/C1QC/MT-ND4/C1QB/CSNK2B/TUBB4A/MT-CYB/ATF6B/ATF4/NDUFS1/TNF/NCF4/PSMA6	2.81899757176675
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	14/399	157/9376	2.09542965694491	HLA-E/HLA-A/HLA-B/SQSTM1/ZFP36L1/HLA-G/PTEN/CDKN1A/ZFP36L2/GADD45B/RAD50/IGFBP3/HLA-F/SIRT1	2.91809137346207
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	18/399	227/9376	1.86333675598688	HLA-E/HLA-A/HLA-B/B2M/HLA-G/CDKN1A/CCL3/CCL4/VEGFA/ATF6B/TAPBP/HLA-F/CCR1/GNG10/ATF4/TNF/PTGER2/PXN	2.77595754207459
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	19/399	250/9376	1.78590476190476	NEU1/PSAP/ATP6V0C/CTSK/CTSB/CTSD/IDS/MCOLN2/CLTC/TPP1/CLN8/SCARB2/HEXB/TLR7/CLN3/CTSA/CTSL/PLEKHM1/ASAH1	2.65525457499799
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/399	45/9376	3.13316624895572	HLA-E/HLA-A/HLA-B/HLA-G/HLA-F/TNF	3.02394118003752
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/399	136/9376	2.0734188412207	HSPA1A/HSPA1B/JUN/CSNK2B/FOS/MX1/IRF7/CD209/TLR7/ADAR/NFKBIB/IRF9	2.65833161334407
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/399	139/9376	2.02866879428788	HSPA1A/HSPA1B/JUN/CTSD/FOS/HSP90AA1/KRT19/KCNJ5/KRT18/HBEGF/ATF6B/ATF4	2.57587015384284
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	13/399	157/9376	1.94575611002027	JUN/MT-CO3/SOCS3/FOS/BCL2L11/CDC42/MT-CYB/ATF4/CEBPA/ADIPOR2/MLXIP/NDUFS1/TNF	2.51937924863759
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	16/399	214/9376	1.75691565362003	HLA-E/HLA-A/HLA-B/B2M/HLA-G/PLCG2/JUN/SKP1/FOS/CFL2/TAPBP/HLA-F/GNG10/TNF/PXN/BST2	2.36137903588571
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/399	115/9376	2.04336929279721	EGR1/CDKN1A/MAFB/FOS/PDE4C/HBEGF/ATF6B/ATF4/RXRB/LRP6	2.37336483018296
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/399	101/9376	2.09394774063873	FN1/PLCG2/JUN/EGR1/THBD/CDC42/VEGFA/TNF/COL4A5	2.33027285869851
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/399	55/9376	2.5634996582365	NEU1/PSAP/HEXB/SGPP1/ASAH1/PLPP3	2.45162676982629
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/399	70/9376	2.34987468671679	SOCS3/NFKBIB/PCK2/RXRB/ADIPOR2/SLC2A1/TNF	2.38983227891774
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/399	70/9376	2.34987468671679	HLA-E/HLA-A/HLA-B/HLA-G/EIF4G2/HLA-F/ITGB2	2.38983227891774
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/399	105/9376	2.01417830290011	PLCG2/JUN/LSP1/EGR2/CD209/PLK3/EGR3/IRF9/TNF	2.20319099356601
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/399	89/9376	2.11224690940835	SPP1/FN1/ITGA11/TNXB/CD44/LAMA3/ITGA5/COL4A5	2.22261868816694
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/399	157/9376	1.79608256309564	BSG/DUSP8/C1QA/STAB1/C1QC/C1QB/SLC16A1/SLC2A1/LRP1/PTGER2/SIRT1/DUSP16	2.12066712381311
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/399	30/9376	3.13316624895572	FOLR2/SHMT1/ABCC1/TNF	2.46705547967399
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/399	233/9376	1.61364785353943	FN1/NID1/ITGA11/FBN1/ZYX/PDLIM4/TPM1/FHL1/ATP1B2/TNNT2/ENO2/ITGA5/TNNT3/CSRP1/MYOZ3/COL4A5	1.99967443114931
NA	NA	hsa04981	Folate transport and metabolism	4/399	31/9376	3.03209636995715	FOLR2/SLCO2B1/SHMT1/ABCC1	2.38914202475678
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/399	76/9376	2.16435826408126	UBC/ANGPTL4/PLTP/OLR1/PCK2/RXRB/SCD	2.14861411908143
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/399	109/9376	1.94026350279368	PPP1R3C/PTEN/PPP1R3B/SOCS3/GFPT2/PCK2/MLXIP/SLC2A1/TNF	2.08161169789831
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/399	144/9376	1.79504316346422	C1QA/C2/CD14/C1QC/C1QB/ADIPOR2/SCD/TNF/SIRT1/C3AR1/TCF7L2	2.02689162892474
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	13/399	180/9376	1.69713171818435	HLA-E/HLA-A/HLA-B/B2M/HLA-G/SOCS3/IRF7/TAPBP/HLA-F/IRF9/TNF/ITGA5/BST2	1.99093961204463
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/399	93/9376	2.02139757997143	CSNK2B/ACTN4/TJP1/CDC42/CTNNA3/HEG1/ARHGAP29/TCF7L2	2.08688538233405
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/399	62/9376	2.27407227746786	HSPA1A/HSPA1B/EIF4EBP2/CRYAB/SOD2/SIRT1	2.121916390163
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/399	78/9376	2.10886189833558	JUN/FOS/NFKBIB/TNF/NCF4/CR1/ITGB2	2.0731773947478
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/399	63/9376	2.23797589211123	POLR2J3/POLR2A/GTF2H1/POLD4/GTF2H2/ERCC5	2.07847178877085
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/399	80/9376	2.05614035087719	HGF/PDGFD/PLCG2/PTEN/BCL2L11/VEGFA/PDGFB	1.99997720152448
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	19/399	300/9376	1.48825396825397	HSPA1A/HGF/PDGFD/HSPA1B/JUN/FLT1/DUSP8/CD14/CSF1R/FOS/GADD45B/CDC42/VEGFA/PDGFB/ATF4/HSPB1/TNF/MKNK2/DUSP16	1.81203106517481
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	12/399	169/9376	1.66855007340837	SQSTM1/CTSB/GABARAP/CTSD/UBC/DDIT4/PTEN/SMCR8/GABARAPL1/CTSL/PPP2CA/PLEKHM1	1.84894799072713
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/399	100/9376	1.87989974937343	CCL3/CCL4/CSF1R/TNFSF10/IL18/IL6ST/CCR1/TNF	1.86491609652679
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	16/399	248/9376	1.51604818497858	JUN/TUBB/SKP1/CD14/AHNAK/TUBB4A/TNFSF10/FOS/IL18/DYNLRB1/HSP90AA1/CDC42/AHNAK2/TNF/PLEKHM1/TCF7L2	1.73633993155758
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/399	67/9376	2.10436539108966	LDHA/TPI1/ACSS1/PCK2/GCK/ENO2	1.91251631119079
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/399	173/9376	1.62997088095962	TNFSF10/SOCS3/MX1/DNAJB1/IRF7/IL18/TLR7/RSAD2/ADAR/NFKBIB/IRF9/TNF	1.7631338750249
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/399	68/9376	2.0734188412207	CD14/CSF1R/CEBPA/ZBTB16/TCF7L2/SPI1	1.87284552011257
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/399	52/9376	2.25949489107384	ANGPTL4/PLTP/APOC2/LRP1/SCARB1	1.92000970110952
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/399	37/9376	2.54040506672086	GFPT2/UGP2/GCK/PGM3	1.97921095544542
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/399	37/9376	2.54040506672086	HBA2/HBA1/IL18/TNF	1.97921095544542
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/399	37/9376	2.54040506672086	CDKN1A/GADD45B/RXRB/TCF7L2	1.97921095544542
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/399	103/9376	1.8251453877412	JUN/C1QA/C1QC/C1QB/CCL3/FOS/PPP2CA/TNF	1.77519241007004
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/399	103/9376	1.8251453877412	FN1/CD14/ACTN4/LAMA3/HSPB1/TNF/COL4A5/ITGB2	1.77519241007004
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/399	23/9376	3.06505393919582	GLS/ATP1B2/PCK2	2.09038521100897
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/399	69/9376	2.04336929279721	JUN/FOSB/FOS/ATF6B/ATF4/SIRT1	1.83385170249698
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/399	86/9376	1.91268869849041	KCNMB2/ATP1B2/ATF6B/ATF4/GCK/SLC2A1/VAMP2	1.79254684881697
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/399	54/9376	2.17580989510814	LDHA/AMD1/BCAT1/MAT2A/DNMT3B	1.82677859745061
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/399	54/9376	2.17580989510814	HLA-E/HLA-A/HLA-B/HLA-G/HLA-F	1.82677859745061
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/399	71/9376	1.98580959440856	ATP6V0C/PLCG2/JUN/TJP1/CDC42/HBEGF	1.75780420760412
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/399	71/9376	1.98580959440856	LDHA/PTEN/GLS/GCK/SLC2A1/PDK1	1.75780420760412
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/399	106/9376	1.77349032959758	PDGFD/FOLR2/PTEN/CDKN1A/HSP90AA1/PDGFB/ATF4/TCF7L2	1.68839643858112
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/399	90/9376	1.82768031189084	ATF6B/SESN2/ATF4/EHMT2/ADIPOR2/SOD2/SIRT1	1.66332077997809
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/399	73/9376	1.93140385209599	MX1/CHMP4A/NELFE/SUPT4H1/MLLT1/BST2	1.68420294639661
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/399	73/9376	1.93140385209599	HGF/PDGFD/PTEN/CDKN1A/GADD45B/PDGFB	1.68420294639661
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	13/399	204/9376	1.49746916310384	FN1/HGF/PLCG2/CDKN1A/CDC42/CD44/VEGFA/HBEGF/CTSL/TNF/ITGA5/PXN/EIF4B	1.51445264901707
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/399	110/9376	1.70899977215767	SKP1/FBN1/BMP6/LEFTY2/PPP2CA/TNF/GDF6/INHBA	1.57689495496414
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/399	26/9376	2.71139386928861	HES1/GCK/MAFA	1.84220227327655
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	13/399	205/9376	1.49016443547894	MT-ND1/MT-CO3/MT-ND2/CTSD/PTEN/MT-ATP6/MT-ND4/GFPT2/PDK4/MT-CYB/SLC2A1/NDUFS1/NCF4	1.49594922985394
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/399	75/9376	1.87989974937343	BCAT1/MAT2A/TPI1/SHMT1/ENO2/GPT2	1.61289270249218
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/399	93/9376	1.768722882475	FN1/PTEN/CDKN1A/GADD45B/LAMA3/RXRB/COL4A5	1.57062888923983
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/399	187/9376	1.50794097543324	TXNIP/JUN/CTSB/GABARAP/YWHAE/IRF7/IL18/HSP90AA1/GABARAPL1/NFKBIB/IRF9/TNF	1.47913018388938
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	14/399	227/9376	1.44926192132313	MT-ND1/HGF/JUN/MT-CO3/MT-ND2/PTEN/MT-ATP6/MT-ND4/FOS/VEGFA/CBR1/MT-CYB/NDUFS1/SOD2	1.44454873514364
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/399	59/9376	1.99141922603118	PTEN/CDKN1A/GADD45B/CTNNA3/TCF7L2	1.61046677033275
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/399	60/9376	1.95822890559733	PLCG2/CDC42/VEGFA/HSPB1/PXN	1.56977217311732
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/399	78/9376	1.80759591285907	FN1/CDC42/CLTC/CTNNA3/ITGA5/PXN	1.50991714400438
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/399	28/9376	2.51772287862513	ATP6V0C/SLC12A7/SLC4A1	1.69558129959394
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/399	116/9376	1.62060323221848	PLCG2/ACTN4/CDC42/ARHGAP5/CTNNA3/PXN/NCF4/ITGB2	1.41789479375238
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	11/399	174/9376	1.48555296286694	HSPA1A/HSPA1B/CANX/SKP1/PPP1R15A/DNAJB1/HSP90AA1/ATF6B/CRYAB/ATF4/WFS1	1.3629395422657
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	10/399	156/9376	1.50632992738256	YWHAE/CDKN1A/SOCS3/MX1/IRF7/RSAD2/PPP2CA/IRF9/TNF/SCARB1	1.34442602204511
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/399	15/9376	3.13316624895572	HEXB/ST6GALNAC6	1.74307343438356
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/399	47/9376	1.99989335039727	SOCS3/GCK/MAFA/TNF	1.44874361884751
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/399	323/9376	1.30952768919202	PLCG2/DDIT4/PTEN/CDKN1A/TNXB/BCL2L11/CD44/VEGFA/GLS/MCL1/PDGFB/TPM1/BMF/DNMT3B/IGF2BP1/ABCC1/ITGA5/SIRT1	1.19346855225629
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/399	122/9376	1.54090143391265	EEF2K/EEF2/PCK2/ADIPOR2/PPP2CA/SCD/SIRT1/PFKFB3	1.26776796641825
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/399	122/9376	1.54090143391265	CSH1/JUNB/PLCG2/SOCS3/FOS/ATF6B/IGFBP3/ATF4	1.26776796641825
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	11/399	181/9376	1.42810063833617	ATP6V0C/CTSD/CD14/MRC1/IL18/LSP1/CD209/PLK3/TNF/CR1/ITGB2	1.22607142129361
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	9/399	142/9376	1.48935719580642	SQSTM1/JUN/THBD/FOS/HSP90AA1/VEGFA/PDGFB/CTSL/TNF	1.23874435775211
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/399	32/9376	2.20300751879699	LDHA/ACSS1/BCKDHA	1.43708808759085
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/399	32/9376	2.20300751879699	GABARAP/GABARAPL1/PPP2CA	1.43708808759085
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/399	49/9376	1.91826505038105	JUN/FOSB/ATF6B/ATF4	1.35863118942987
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	10/399	163/9376	1.44164091209619	JUN/CDKN1A/FOS/IRF7/DDX3X/EGR2/ATF6B/ATF4/EGR3/TNF	1.199137647854
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/399	105/9376	1.56658312447786	SQSTM1/JUN/GABARAP/UBC/CSNK2B/GABARAPL1/ATF4	1.23083962000227
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/399	17/9376	2.76455845496093	CD209/PCDH7	1.53515510242963
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	17/399	308/9376	1.29700875565537	MT-ND1/GPX3/MT-CO3/MT-ND2/TUBB/MT-ATP6/MT-ND4/POLR2J3/TUBB4A/CLTC/POLR2A/TGM2/DNAH8/MT-CYB/NDUFS1/SOD2/PSMA6	1.11736568106458
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/399	33/9376	2.13624971519708	BCAT1/BCKDHA/GPT2	1.37845964458805
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/399	87/9376	1.62060323221848	JUN/CDKN1A/FOS/GADD45B/BCL2L11/TCF7L2	1.22601462668334
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/399	18/9376	2.61097187412977	NEU1/HEXB	1.44224540423115
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/399	89/9376	1.58418518205626	PDGFD/TUBB/TUBB4A/TJP1/GJA1/PDGFB	1.16738548968335
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/399	89/9376	1.58418518205626	GABARAP/GLS/GABARAPL1/GABRA3/GNG10/GABRE	1.16738548968335
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	14/399	250/9376	1.3159298245614	HSPA1A/HLA-E/HSPA1B/HLA-A/HLA-B/HLA-G/FOLR2/CHMP4A/CDC42/CLTC/HLA-F/SPG21/EHD4/RUFY1	1.06739919734274
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/399	109/9376	1.5090938355062	JUN/FOS/HSP90AA1/IL6ST/NFKBIB/RXRB/EBI3	1.12706244597282
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	14/399	253/9376	1.30032591359823	SQSTM1/PLCG2/JUN/UBC/SKP1/CD14/ACTN4/IL18/CDC42/CD44/NFKBIB/TNF/ITGA5/PXN	1.02091762970337
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/399	91/9376	1.54936792530777	PLCG2/JUN/FOS/NFKBIB/LILRB4/LILRB5	1.11019563441447
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/399	72/9376	1.63185742133111	IRF7/DDX3X/ADAR/NFKBIB/TNF	1.13463705214581
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/399	19/9376	2.47355230180715	IDS/HEXB	1.35544067579272
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/399	73/9376	1.60950321007999	HGF/PLCG2/CDKN1A/GADD45B/RXRB	1.1021288992362
NA	NA	hsa04519	Cadherin signaling	21/399	404/9376	1.22146951537259	KRT7/YWHAE/PCDHGA3/ACTN4/KRT8/PCDH19/TJP1/CDC42/KRT19/GJA1/PCDH12/KRT18/PCDH10/PCDH7/GABRA3/CTNNA3/PCDHGA10/GABRE/SAV1/TCF7L2/LRP6	0.959326582783667
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/399	133/9376	1.41345845817551	HLA-E/HLA-A/HLA-B/HLA-G/PLCG2/TNFSF10/TNF/ITGB2	1.01241296518709
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/399	37/9376	1.90530380004064	GFPT2/GLS/GPT2	1.16319222635451
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/399	20/9376	2.34987468671679	LSS/FDFT1	1.27400114436913
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/399	20/9376	2.34987468671679	UGP2/NPL	1.27400114436913
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/399	75/9376	1.56658312447786	PTEN/CDKN1A/GADD45B/IGFBP3/SESN2	1.03857034562891
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/399	75/9376	1.56658312447786	CANX/GPX3/ATP1B2/ATF6B/ATF4	1.03857034562891
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/399	155/9376	1.36444336648072	CDKN1A/KMT2A/RASD1/CDKN2C/ATF6B/ATF4/SCARB1/TCF7L2/CYP11A1	0.964524716632717
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/399	38/9376	1.85516422635536	SIRT1/SIRT2/NAPRT	1.11357856296571
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/399	76/9376	1.54597018862947	PLCG2/PTEN/CDKN1A/GADD45B/PDGFB	1.00748995569027
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/399	157/9376	1.34706192232173	YWHAE/BMP6/DLG5/CTNNA3/PPP2CA/GDF6/SAV1/TCF7L2/ITGB2	0.924530749339688
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/399	138/9376	1.36224619519814	MT-ND1/ATP6V0C/MT-CO3/MT-ND2/MT-ATP6/MT-ND4/MT-CYB/NDUFS1	0.903776137273614
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/399	138/9376	1.36224619519814	FN1/JUN/FOS/IL18/CDC42/TNF/ITGA5/PXN	0.903776137273614
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/399	98/9376	1.43869878778579	KCNJ5/ATP1B2/ATF6B/ATF4/SCARB1/CYP11A1	0.920362174616357
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/399	160/9376	1.3218045112782	HLA-E/HLA-A/HLA-B/HLA-G/SIGLEC1/NFASC/HLA-F/NLGN2/ITGB2	0.865540431796106
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	7/399	119/9376	1.38227922748047	JUNB/JUN/SOCS3/FOS/ATF6B/ATF4/TNF	0.884760085638769
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	14/399	268/9376	1.22754647813564	MT-ND1/MT-CO3/MT-ND2/TUBB/UBC/MT-ATP6/MT-ND4/TUBB4A/MT-CYB/SLC39A14/ATF4/SLC39A1/NDUFS1/PSMA6	0.796769089859983
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/399	100/9376	1.40992481203008	CD14/CSF1R/CD44/TNF/ITGA5/CR1	0.868821000193464
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/399	41/9376	1.7194205024757	POLD4/RAD50/TOP3A	0.973249190378186
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/399	41/9376	1.7194205024757	CDKN1A/VEGFA/HBEGF	0.973249190378186
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/399	23/9376	2.04336929279721	GLS/GPT2	1.05616792757168
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/399	61/9376	1.54090143391265	ATP7B/CYBRD1/ATP1B2/FTL	0.893507277412541
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/399	42/9376	1.67848191908342	SAT1/SLC39A14/FTL	0.929042323056909
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/399	83/9376	1.41558716067277	SKP1/CSNK2B/PHF1/RING1/CBX7	0.801732839372292
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/399	83/9376	1.41558716067277	CCL4/IRF7/IL18/ADAR/NFKBIB	0.801732839372292
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/399	63/9376	1.49198392807415	PTGDS/CBR1/HPGDS/HPGD	0.826005354019381
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/399	125/9376	1.3159298245614	CTSD/PTEN/SGPP1/ABCC1/PPP2CA/TNF/ASAH1	0.749648654426303
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/399	168/9376	1.25886143931257	CSH1/CDKN1A/SOCS3/IL6ST/MCL1/PDGFB/FHL1/SOCS7/IRF9	0.713749505879731
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/399	298/9376	1.18282282888429	CSH1/BMP6/CCL3/CCL4/CSF1R/TNFSF10/IL18/IL6ST/CCR1/TNF/EBI3/TNFRSF21/GDF6/TNFSF9/INHBA	0.676160724852495
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/399	44/9376	1.60218728639781	TAF15/GTF2H1/GTF2H2	0.844067209278907
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/399	105/9376	1.34278553526674	PLCG2/CD14/CSNK2B/CCL4/GADD45B/TNF	0.744663933220396
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/399	148/9376	1.27020253336043	JUN/PTEN/CDKN1A/HES1/FOS/GADD45B/TCF7L2/LRP6	0.698510525690286
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/399	65/9376	1.44607673028726	ATF6B/ATF4/SCARB1/CYP11A1	0.760807100567203
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/399	149/9376	1.26167768414324	MT-ND1/MT-ND2/MT-ND4/KCNJ5/GABRA3/GNG10/NDUFS1/GABRE	0.678790936752237
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/399	86/9376	1.36620621320744	ITGA11/GJA1/CTNNA3/ITGA5/TCF7L2	0.719239533247143
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/399	107/9376	1.31768674021502	LDHA/ATF4/PCK2/GCK/SLC2A1/SIRT1	0.696756469012342
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/399	26/9376	1.80759591285907	ABCC1/SCARB1	0.86932356908364
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/399	66/9376	1.42416647679806	JUN/IL18/MAF/TNF	0.729020838751162
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/399	87/9376	1.3505026935154	MT-CO3/TPM1/MT-CYB/ATP1B2/TNNT2	0.692425380070378
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/399	130/9376	1.26531713900135	JUN/FOS/VEGFA/ATF6B/GNG10/ATF4/COL4A5	0.642194394699479
NA	NA	hsa04382	Cornified envelope formation	11/399	217/9376	1.19118071676888	KRT7/KRT8/TJP1/KRT19/KRT18/ABHD5/LAMA3/PPP2CA/PRSS8/DST/COL4A5	0.600698291017234
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/399	27/9376	1.74064791608651	HACD4/SCD	0.812489170125397
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/399	47/9376	1.49992001279795	LDHA/ACSS1/PCK2	0.724333178320909
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/399	68/9376	1.38227922748047	DHRS3/CYP2W1/CYP26B1/RDH13	0.666980968775153
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/399	90/9376	1.30548593706488	JUN/PTEN/CSNK2B/FOS/NFKBIB	0.613909863278369
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/399	91/9376	1.29113993775648	PDE4C/KCNJ5/GABRA3/GNG10/GABRE	0.588353038120786
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	10/399	200/9376	1.1749373433584	JUN/TUBB/TUBB4A/TNFSF10/FOS/IL18/TJP1/CDC42/NFKBIB/TNF	0.527202299402371
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/399	178/9376	1.1881388865422	FRZB/JUN/NOTUM/SKP1/CSNK2B/CCN4/SIRT1/TCF7L2/LRP6	0.534254687620009
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/399	71/9376	1.32387306293904	SOCS3/FOS/SOCS7/GCK	0.577500397635542
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/399	50/9376	1.40992481203008	AOC1/AMD1/SAT1	0.612700135328865
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/399	93/9376	1.26337348748215	JUN/FOS/MAF/NFKBIB/MAML1	0.538115903051388
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/399	93/9376	1.26337348748215	JUN/EGR1/CDC42/HBEGF/ATF4	0.538115903051388
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/399	51/9376	1.38227922748047	LPCAT1/PLD3/PLPP3	0.577095703477552
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/399	51/9376	1.38227922748047	ATP6V0C/PLCG2/TJP1	0.577095703477552
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/399	94/9376	1.24993334399829	JUN/FOSB/FOS/HSP90AA1/TNF	0.513421224439997
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/399	116/9376	1.21545242416386	TPI1/ACSS1/SHMT1/GCK/ENO2/GPT2	0.492245052335983
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/399	138/9376	1.19196542079837	PPP1R3C/PPP1R3B/SOCS3/FLOT1/PCK2/GCK/MKNK2	0.47893882337221
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/399	52/9376	1.3556969346443	BMP6/SCARB1/CYP11A1	0.542234486230991
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/399	31/9376	1.51604818497858	ACSS1/SHMT1	0.606719456694749
NA	NA	hsa04517	IgSF CAM signaling	14/399	299/9376	1.10027577304465	PLCG2/TUBB/TUBB4A/ACTN4/TJP1/CDC42/NFASC/CD209/CD84/PPFIA1/NLGN2/ITGA5/PXN/ITGB2	0.371506929331884
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/399	32/9376	1.468671679198	UGP2/GCK	0.559865567457268
Human Diseases	Immune disease	hsa05310	Asthma	2/399	32/9376	1.468671679198	PRG2/TNF	0.559865567457268
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	17/399	368/9376	1.08553993679852	MT-ND1/SQSTM1/GPX3/MT-CO3/MT-ND2/TUBB/MT-ATP6/MT-ND4/TUBB4A/FUS/SMCR8/DNAH8/MT-CYB/ATF4/NDUFS1/TNF/PSMA6	0.352927190631999
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	11/399	232/9376	1.1141647221502	FN1/PDGFD/ITGA11/ACTN4/CFL2/CDC42/PDGFB/ITGA5/PXN/PIP4K2B/ITGB2	0.371205396469772
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/399	120/9376	1.1749373433584	PLCG2/JUN/YWHAE/CDC42/ATF4/NFKBIB	0.406600539398566
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/399	12/9376	1.95822890559733	CD209	0.700221854708604
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/399	143/9376	1.15028830818305	C1QA/C2/C1R/C1QC/C1QB/ACTN4/TNF	0.381793271141413
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/399	99/9376	1.18680539733171	JUN/CDKN1A/FOS/CDKN2C/HBEGF	0.393921524964379
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/399	99/9376	1.18680539733171	PDGFD/JUN/FOS/PDGFB/PLPP3	0.393921524964379
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/399	99/9376	1.18680539733171	ITGA11/TPM1/TNNT2/TNF/ITGA5	0.393921524964379
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/399	77/9376	1.22071412296976	CDKN1A/GADD45B/CDC42/VEGFA	0.409981099393726
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/399	122/9376	1.15567607543449	JUN/FOS/CDC42/NFKBIB/PPP2CA/TNF	0.364874502450343
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/399	122/9376	1.15567607543449	PLCG2/DIO2/ATP1B2/RXRB/SLC2A1/MED17	0.364874502450343
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/399	78/9376	1.20506394190605	PLCG2/PTEN/TPI1/PIP4K2B	0.383396642517544
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/399	78/9376	1.20506394190605	BTG2/TOB2/ENO2/EXOSC6	0.383396642517544
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/399	34/9376	1.38227922748047	POLR2J3/POLR2A	0.470767746103275
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/399	34/9376	1.38227922748047	BHLHE40/SKP1	0.470767746103275
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/399	13/9376	1.80759591285907	RAD50	0.614277701102864
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	8/399	170/9376	1.10582338198437	JUN/ACTN4/TJP1/CDC42/YBX3/ARHGAP17/SYNPO/PPP2CA	0.293546621130313
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/399	35/9376	1.34278553526674	TPI1/PFKFB3	0.42831797148878
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/399	150/9376	1.0966081871345	HGF/CDKN1A/GADD45B/CTNNA3/RXRB/TCF7L2/LRP6	0.251454441131386
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/399	36/9376	1.30548593706488	UGP2/DCXR	0.387146652251403
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/399	36/9376	1.30548593706488	UGP2/GCK	0.387146652251403
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/399	36/9376	1.30548593706488	POLD4/RNASEH2A	0.387146652251403
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/399	105/9376	1.11898794605562	ITGA11/TPM1/TNNT2/TNF/ITGA5	0.258488246438526
Genetic Information Processing	Translation	hsa03010	Ribosome	10/399	222/9376	1.05850211113369	RPS9/RPL7A/RPS18/RPS25/RPL36A/RPS17/RPL17/RPS10/MRPS18B/MRPS24	0.185972635264778
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/399	83/9376	1.13246972853821	ECH1/AMACR/DECR2/SOD2	0.255554891108497
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/399	154/9376	1.06812485759854	DHRS3/BCAT1/MAT2A/UGP2/SHMT1/NAPRT/RDH13	0.179704884798382
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	17/399	388/9376	1.02958426995323	MT-ND1/MT-CO3/MT-ND2/TUBB/MT-ATP6/MT-ND4/CSNK2B/TUBB4A/MT-CYB/SLC39A14/ATF4/SLC39A1/NDUFS1/TNF/LRP1/PSMA6/LRP6	0.125473398470051
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/399	62/9376	1.13703613873393	HES1/SPEN/MAML1	0.228228204919493
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/399	39/9376	1.20506394190605	MAT2A/SHMT1	0.270535585469423
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/399	86/9376	1.09296497056595	PLCG2/JUN/CDKN1A/HBEGF	0.18258587546223
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/399	133/9376	1.06009384363164	FOS/KCNJ5/ATF6B/GNG10/ATF4/PPP2CA	0.147148486667957
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/399	16/9376	1.468671679198	MIF	0.395546231553539
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/399	16/9376	1.468671679198	HEXB	0.395546231553539
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/399	63/9376	1.11898794605562	CDKN1A/GADD45B/TCF7L2	0.199772136643646
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/399	158/9376	1.04108372196314	CDKN1C/SKP1/YWHAE/CDKN1A/CDKN2C/GADD45B/PPP2CA	0.109795981782505
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/399	158/9376	1.04108372196314	DDIT4/PTEN/FNIP1/SESN2/TNF/EIF4B/LRP6	0.109795981782505
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	5/399	112/9376	1.04905119942714	HSPA1A/HSPA1B/LAMA3/NFKBIB/TNF	0.110094555674584
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/399	17/9376	1.38227922748047	AMACR	0.33258059826218
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/399	41/9376	1.1462803349838	GABRA3/GABRE	0.19789152116365
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/399	43/9376	1.09296497056595	SCARB1/PLPP3	0.128809947865382
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/399	19/9376	1.23677615090357	BCKDHA	0.217797512581499
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/399	44/9376	1.06812485759854	POLD4/POLG2	0.0954884962445679
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/399	44/9376	1.06812485759854	AQP3/VAMP2	0.0954884962445679
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	20/399	480/9376	0.979114452798663	MT-ND1/SQSTM1/GPX3/MT-CO3/MT-ND2/TUBB/UBC/MT-ATP6/MT-ND4/CSNK2B/TUBB4A/FUS/SMCR8/DNAH8/MT-CYB/ATF4/NDUFS1/TNF/PSMA6/LRP6	-0.0990320030456833
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/399	45/9376	1.04438874965191	ABCC1/DEFB1	0.0629247570687425
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/399	168/9376	0.979114452798663	SQSTM1/TNFSF10/CHMP4A/HSP90AA1/FTL/IRF9/TNF	-0.0575869818021913
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	9/399	217/9376	0.974602404629084	KLF4/JUN/FOS/HSP90AA1/CHRNA3/VEGFA/ATF6B/ATF4/RXRB	-0.0798003710473569
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/399	193/9376	0.974041320918878	PLCG2/CCL3/CCL4/CDC42/CCR1/GNG10/NFKBIB/PXN	-0.076820198533988
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/399	46/9376	1.02168464639861	PSME1/PSMA6	0.0310811380367261
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/399	170/9376	0.967595459236326	HGF/PLCG2/PTEN/CDKN1A/GADD45B/TCF7L2/LRP6	-0.0898879176991399
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/399	97/9376	0.969020489367749	FOS/RASD1/KCNJ5/GNG10	-0.0646571125997587
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/399	21/9376	1.11898794605562	DSEL	0.115079295038288
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/399	21/9376	1.11898794605562	BCAT1	0.115079295038288
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/399	98/9376	0.959132525190527	PLCG2/CFL2/CDC42/PLPP3	-0.0857373647567298
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/399	48/9376	0.979114452798663	BCAT1/BCKDHA	-0.0305829011991006
NA	NA	hsa03272	Virion - Hepatitis viruses	2/399	48/9376	0.979114452798663	CHMP4A/SCARB1	-0.0305829011991006
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/399	48/9376	0.979114452798663	TAS1R3/ATP1B2	-0.0305829011991006
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/399	22/9376	1.06812485759854	AOC1	0.0674411144898139
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/399	23/9376	1.02168464639861	POLD4	0.0219506441343879
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/399	23/9376	1.02168464639861	CTSA	0.0219506441343879
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/399	77/9376	0.915535592227322	CDKN1A/GADD45B/BCR	-0.156894403911919
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/399	103/9376	0.912572693870599	FUS/DDX39B/PCF11/PPP2CA	-0.188088417604366
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/399	154/9376	0.915535592227322	TPM1/ATP1B2/ATF6B/ATF4/TNNT2/PPP2CA	-0.222806581964549
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/399	154/9376	0.915535592227322	JUN/CDKN1A/FOS/EEF2K/KCNJ5/EEF2	-0.222806581964549
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/399	79/9376	0.892357475968402	ATP6V0C/CLTC/VAMP2	-0.202550106693698
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/399	53/9376	0.886745164798789	CLTC/ATP1B2	-0.174310407671824
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/399	54/9376	0.870323958043256	HES1/TOP3A	-0.201469148230717
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/399	212/9376	0.886745164798789	HGF/PDGFD/FLT1/CSF1R/CDC42/VEGFA/PDGFB/ITGB2	-0.351632182404407
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/399	238/9376	0.888608074808871	HGF/PDGFD/PLCG2/FLT1/CSF1R/CDC42/VEGFA/PDGFB/GNG10	-0.366963682285138
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/399	28/9376	0.839240959541711	HACD4	-0.179598019230403
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/399	28/9376	0.839240959541711	CBR1	-0.179598019230403
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/399	57/9376	0.824517433935716	HACD4/SCD	-0.280151673986838
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/399	243/9376	0.870323958043256	HSPA1A/HSPA1B/HNRNPU/PRPF8/FUS/DDX39B/CWC25/PRPF31/SF1	-0.431780105089618
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/399	86/9376	0.819723727924462	SCN9A/TAS1R3/GABRA3	-0.354067782322682
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/399	29/9376	0.810301616109239	SAV1	-0.215691475835538
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/399	59/9376	0.796567690412472	GPX3/HPGDS	-0.330456547543748
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/399	194/9376	0.847892928196781	TUBB/TUBB4A/DYNLRB1/DNAH8/TPM1/TNNT2/TNNT3	-0.451323658622303
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/399	115/9376	0.817347717118884	FOS/CHRNA3/GNG10/ATF4	-0.415481371107328
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/399	30/9376	0.783291562238931	PCK2	-0.250628257001423
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/399	31/9376	0.758024092489288	BAG6	-0.284491827336266
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/399	90/9376	0.783291562238931	ATP1B2/SLC2A1/SCARB1	-0.435501053421355
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/399	32/9376	0.734335839598998	BCL2L11	-0.317356952676312
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/399	63/9376	0.745991964037077	KMT2A/EHMT2	-0.42646108073209
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/399	33/9376	0.712083238399028	VAMP2	-0.349290857070603
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/399	65/9376	0.723038365143628	SPP1/KCNJ5	-0.472372495753671
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	8/399	235/9376	0.799957340158908	MT-ND1/MT-CO3/MT-ND2/MT-ATP6/MT-ND4/MT-CYB/KDM3A/NDUFS1	-0.654735924238701
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/399	98/9376	0.719349393892896	PLCG2/PTEN/PIP4K2B	-0.588787134443273
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/399	69/9376	0.68112309759907	PLCG2/TNF	-0.5604659389459
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/399	69/9376	0.68112309759907	CTSB/PTGER2	-0.5604659389459
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/399	37/9376	0.635101266680214	MIF	-0.468845231827292
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/399	184/9376	0.766263484798954	PLCG2/SEMA6A/SEMA4A/CFL2/CDC42/SEMA7A	-0.67505155487691
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/399	70/9376	0.671392767633369	CBR1/HPGDS	-0.581769684788792
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/399	38/9376	0.618388075451787	ATP1B2	-0.496927777673883
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/399	103/9376	0.684429520402949	COL16A1/ATP1B2/COL4A5	-0.678908624522967
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/399	104/9376	0.677848467322152	LPCAT1/PLD3/PLPP3	-0.696460729688071
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/399	41/9376	0.5731401674919	SHMT1	-0.577466148050886
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/399	75/9376	0.626633249791145	CDKN1A/ATP7B	-0.684396724960888
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/399	42/9376	0.559493973027808	AOC1	-0.603182975268787
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/399	44/9376	0.534062428799271	HEXB	-0.653090216789771
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/399	79/9376	0.594904983978935	CBR1/HPGDS	-0.762264165155269
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/399	142/9376	0.661936531469519	UBC/SKP1/SOCS3/HERC2	-0.855763883300294
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/399	46/9376	0.510842323199303	FTL	-0.701121751994289
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/399	144/9376	0.652742968532442	KLF4/LEFTY2/IL6ST/INHBA	-0.885300827064503
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/399	82/9376	0.5731401674919	IMPDH2/UPP1	-0.818459803812277
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/399	116/9376	0.607726212081929	DLGAP1/GLS/GNG10	-0.896229559788618
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/399	117/9376	0.602531970953024	INO80D/SRCAP/CHD4	-0.912051923348609
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/399	85/9376	0.552911690992186	IMPDH2/UPP1	-0.872927187393169
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/399	149/9376	0.630838842071622	PDGFD/PLCG2/PDGFB/PLPP3	-0.957602666896017
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/399	93/9376	0.505349394992859	ATP1B2/VAMP2	-1.01065357623127
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/399	254/9376	0.647603260118801	HGF/PDGFD/PLCG2/FLT1/MCOLN2/VEGFA/PDGFB	-1.20035630998506
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/399	195/9376	0.602531970953024	PLCG2/TLR7/NCF4/CR1/ITGB2	-1.18244510207889
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/399	59/9376	0.398283845206236	UPP1	-0.977430986835912
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/399	59/9376	0.398283845206236	ABHD5	-0.977430986835912
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/399	60/9376	0.391645781119465	PPP2CA	-0.996606884449895
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/399	166/9376	0.566234864269107	KCNMB2/ATP1B2/ATF6B/ATF4	-1.1887358068721
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/399	99/9376	0.474722158932685	PLCG2/PTGER2	-1.10766739686758
NA	NA	hsa04082	Neuroactive ligand signaling	5/399	199/9376	0.590420775556983	CHRNA3/GABRA3/GNG10/OGFRL1/GABRE	-1.23117720242321
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/399	138/9376	0.510842323199303	SKP1/YWHAE/PPP2CA	-1.22041043223341
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/399	140/9376	0.503544575725027	SPP1/EGR1/GNG10	-1.24769601882239
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/399	65/9376	0.361519182571814	PLPP3	-1.08896229391411
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/399	66/9376	0.356041619199514	CYP11A1	-1.10678024919805
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/399	67/9376	0.350727565181611	ATF4	-1.12439608486057
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/399	183/9376	0.513633811304217	CSNK2B/RRP7A/UTP4/FBL	-1.40076978138125
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/399	73/9376	0.321900642015999	HPGDS	-1.22616728940541
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/399	115/9376	0.408673858559442	KCNJ5/GNG10	-1.34509677153742
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/399	76/9376	0.309194037725894	ATP1B2	-1.27475837109204
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/399	191/9376	0.492120353239119	FOSB/ATF6B/GNG10/ATF4	-1.49501099134658
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	5/399	226/9376	0.519883780247078	JUN/FOS/PDE4C/ATP1B2/PTGER2	-1.54026881992508
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/399	128/9376	0.367167919799499	IMPDH2/PDE4C	-1.5197635861219
NA	NA	hsa04081	Hormone signaling	4/399	219/9376	0.429200856021332	CSH1/DIO2/GNG10/ADIPOR2	-1.8019188849517
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/399	101/9376	0.23266086007097	TCF7L2	-1.63454752431743
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/399	102/9376	0.230379871246744	ATP1B2	-1.64759107732243
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/399	108/9376	0.217580989510814	DDX39B	-1.72410905443749
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/399	110/9376	0.213624971519708	HSP90AA1	-1.74898619691601
Organismal Systems	Immune system	hsa04611	Platelet activation	1/399	126/9376	0.186497991009269	PLCG2	-1.93811485117889
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/399	370/9376	0.44457088667615	CSH1/CHRNA3/GABRA3/OGFRL1/PTGER2/C3AR1/GABRE	-2.29810572220822
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/399	134/9376	0.175363782590805	KCNMB2	-2.02692787512515
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/399	144/9376	0.163185742133111	PSMA6	-2.13338330820275