category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	32/335	180/9376	4.97565505804312	HLA-E/NFKBIA/HLA-F/IL1B/TNFSF14/ITGA5/HLA-A/HLA-B/IRF7/TAPBP/SRSF3/HLA-DRB1/TNFRSF14/TAP1/CD74/IFIH1/HLA-DRA/HLA-C/HLA-G/OAS2/CFP/EIF2AK2/BIRC3/HLA-DQA1/OAS3/MYD88/OAS1/APAF1/SP100/TAP2/TNF/NXF1	10.3668132415372
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	32/335	205/9376	4.36886785584274	PLCG2/HLA-E/NFKBIA/JUN/HLA-F/NFKB2/ISG15/HLA-A/CCND3/NFKBIE/HLA-B/TNFAIP3/IRF7/TAPBP/HLA-DRB1/MAP2K3/GADD45B/TAP1/HLA-DRA/HLA-C/HLA-G/OAS2/EIF2AK2/HLA-DQA1/OAS3/CDKN1A/MYD88/OAS1/VIM/APAF1/TAP2/TNF	9.38755224404848
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/335	82/9376	6.48503822351656	HLA-E/IFI30/HLA-F/CTSB/HSP90AA1/HLA-A/HLA-B/TAPBP/HLA-DRB1/LGMN/TAP1/CD74/HSP90AB1/HLA-DRA/HLA-C/HLA-G/HLA-DQA1/TAP2/TNF	9.60251640083182
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	23/335	155/9376	4.15306692344728	HLA-E/NCF1/HLA-F/FCAR/CORO1A/ITGB2/ITGA5/HLA-A/ATP6V1B2/HLA-B/HLA-DRB1/TAP1/OLR1/CD14/HLA-DRA/HLA-C/HLA-G/TUBB4B/ATP6V0D1/HLA-DQA1/LAMP1/DYNC1LI1/TAP2	7.61920807258246
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	27/335	224/9376	3.37356076759062	HLA-E/NFKBIA/TLN1/JUN/HLA-F/NFKB2/SPI1/ITGB2/ATF4/HLA-A/CCND3/HLA-B/GPS2/HLA-DRB1/IL1R2/FOS/HLA-DRA/HLA-C/HLA-G/TGFB1/ETS2/HLA-DQA1/CDKN1A/PRKACA/MAP3K3/CRTC2/TNF	6.92095723130476
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	17/335	95/9376	5.0083896307934	JUN/VEGFA/CCL3/LTB/FLT1/IL1B/ITGB2/ATP6V1B2/CCL3L1/HLA-DRB1/FOS/HLA-DRA/CCL20/ATP6V0D1/TGFB1/HLA-DQA1/TNF	7.55847452025306
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	27/335	238/9376	3.17511601655588	PLCG2/NFKBIA/JUN/ISG15/C1QA/IL1B/C3AR1/MX1/C1QB/RPS9/ADAM17/C1QC/F13A1/RPLP0/ADAR/FOS/IFIH1/MX2/RPS2/OAS2/RPS4Y1/EIF2AK2/OAS3/MYD88/RPL36A/OAS1/TNF	6.54252114787
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	26/335	227/9376	3.20568084686699	HLA-E/NFKBIA/VEGFA/HLA-F/CCL3/CCL4/IL1B/ATF4/HLA-A/HLA-B/CCL3L1/TAPBP/GRB2/TAP1/HLA-C/HLA-G/ARHGEF1/PLCB2/CDKN1A/PRKACA/CALM2/CCL4L2/PTGER4/TAP2/GNB2/TNF	6.47542971536804
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	20/335	142/9376	3.94198023964684	PLCG2/SQSTM1/NFKBIA/NCF1/JUN/NFKB2/FOSB/IL1B/SPI1/LILRB3/GRB2/LILRA2/FOS/JUND/CSF1R/TGFB1/OSCAR/JUNB/LILRB2/TNF	6.79968502154079
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	22/335	173/9376	3.55917522215512	NFKBIA/IL1B/MX1/RSAD2/CCND3/IRF7/HLA-DRB1/ADAR/IFIH1/MX2/HLA-DRA/OAS2/EIF2AK2/DNAJB1/HLA-DQA1/OAS3/MYD88/OAS1/APAF1/PABPN1/TNF/NXF1	6.53970517728854
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/335	44/9376	6.99701492537313	HLA-E/HLA-F/IL1B/HLA-A/HLA-B/HLA-DRB1/HLA-DRA/HLA-C/HLA-G/HLA-DQA1/TNF	7.67492093154598
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/335	45/9376	6.84152570480929	HLA-E/HLA-F/IL1B/HLA-A/HLA-B/HLA-DRB1/HLA-DRA/HLA-C/HLA-G/HLA-DQA1/TNF	7.56080889964286
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	24/335	216/9376	3.10978441127695	NFKBIA/NCF1/JUN/CCL3/IL1B/ATF4/HSP90AA1/CCL3L1/IRF7/RXRA/MAP2K3/SOD2/FOS/OLR1/HSP90AB1/CD14/ARHGEF1/PLCB2/XBP1/MYD88/APAF1/CALM2/ERN1/TNF	6.03833251700952
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/335	39/9376	7.17642556448527	HLA-E/HLA-F/HLA-A/HLA-B/HLA-DRB1/HLA-DRA/HLA-C/HLA-G/HLA-DQA1/TNF	7.43987507196319
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	22/335	187/9376	3.29271290605795	NFKBIA/JUN/TXNIP/IL1B/CTSB/HSP90AA1/TNFAIP3/IRF7/YWHAE/HSP90AB1/NLRP1/OAS2/GPSM3/BIRC3/GSDMD/PLCB2/OAS3/MYD88/OAS1/NLRP12/MFN2/TNF	6.0958765071565
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	16/335	105/9376	4.26484719260839	PLCG2/NFKBIA/NFKB2/LTB/CCL4/IL1B/PLAU/TNFSF14/CFLAR/TNFAIP3/GADD45B/CD14/BIRC3/MYD88/CCL4L2/TNF	6.475808918109
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/335	78/9376	4.66467661691542	JUN/IRF1/C1QA/IL1B/ITGB2/ITGA5/C1QB/C1QC/FOS/CD14/MYD88/CALM2/TNF	6.25587402351804
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/335	78/9376	4.66467661691542	NFKBIA/NCF1/JUN/IL1B/ITGB2/HLA-DRB1/FOS/HLA-DRA/TGFB1/MARCKSL1/HLA-DQA1/MYD88/TNF	6.25587402351804
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	15/335	103/9376	4.0759310244892	NFKBIA/JUN/CCL3/C1QA/IL1B/C1QB/CFLAR/C1QC/CCL3L1/SERPINE1/FOS/TGFB1/PLCB2/MYD88/TNF	6.04205789071683
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	22/335	205/9376	3.00359665089188	HLA-E/NFKBIA/JUN/HLA-F/NFKB2/ATF4/HLA-A/CCND3/HLA-B/IRF7/GRB2/YWHAE/ACTN4/HLA-C/PMAIP1/CHD4/HLA-G/ATP6V0D1/EIF2AK2/CDKN1A/PRKACA/SP100	5.58314218339769
Human Diseases	Infectious disease: viral	hsa05162	Measles	17/335	136/9376	3.49850746268657	NFKBIA/JUN/IL1B/MX1/CCND3/TNFAIP3/IRF7/ADAR/FOS/IFIH1/MX2/OAS2/EIF2AK2/OAS3/MYD88/OAS1/APAF1	5.64955091075831
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/335	54/9376	5.18297401879491	HLA-E/HLA-F/HLA-A/HLA-B/CGA/HLA-DRB1/HLA-DRA/HLA-C/HLA-G/HLA-DQA1	5.93372349515375
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	28/335	333/9376	2.35335036529066	SPP1/FN1/HLA-E/VEGFA/IRF1/HLA-F/ISG15/ITGA5/MX1/OASL/HLA-A/CCND3/ATP6V1B2/HLA-B/GRB2/HES4/MX2/COL4A1/HLA-C/CHD4/HLA-G/ATP6V0D1/EIF2AK2/CDKN1A/PRKACA/PTGER4/TNF/LAMA3	4.84034037969791
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/335	109/9376	3.5947966589073	SPP1/NFKBIA/JUN/CCL3/CCL4/IL1B/CCL3L1/IRF7/MAP2K3/FOS/CD14/MYD88/CCL4L2/TNF	5.24501584611922
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/335	109/9376	3.5947966589073	NFKBIA/JUN/IL1B/HSP90AA1/NFKBIE/HLA-DRB1/RXRA/FOS/HSP90AB1/HLA-DRA/TGFB1/HLA-DQA1/STAT6/EBI3	5.24501584611922
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/335	139/9376	3.22164715988403	JUN/CTSD/ATF4/HSP90AA1/FKBP5/GRB2/FOS/HSP90AB1/KRT19/KRT23/KRT18/PLCB2/GABBR1/PRKACA/CALM2/POMC	5.07945153854777
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/335	156/9376	3.04998086490624	NFKBIA/MX1/RSAD2/IFIT1/CFLAR/IRF7/GRB2/YWHAE/RXRA/MX2/OAS2/EIF2AK2/OAS3/CDKN1A/OAS1/APAF1/TNF	4.96988629823077
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	25/335	300/9376	2.33233830845771	JUN/VEGFA/NFKB2/DUSP2/FLNA/FLT1/IL1B/ATF4/GRB2/MAP2K3/GADD45B/IGF2/MAP3K11/FOS/CD14/JUND/NR4A1/CSF1R/DUSP9/TGFB1/RPS6KA1/MYD88/PRKACA/MAP3K3/TNF	4.5146876209838
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/335	103/9376	3.53247355455731	FN1/IL1B/ITGB2/IL1R2/ACTN4/COL4A1/CD14/TGFB1/PLCB2/PRDX1/PRKACA/TNF/LAMA3	4.97454322009242
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/335	181/9376	2.78334295373959	PLK3/LSP1/IL1B/CTSD/CORO1A/ITGB2/HLA-DRB1/CD74/CD14/HLA-DRA/ATP6V0D1/TGFB1/HLA-DQA1/MYD88/APAF1/LAMP1/CALM2/TNF	4.66335092305489
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	14/335	119/9376	3.29271290605795	NFKBIA/JUN/IRF1/IL1B/ATF4/ADAM17/CFLAR/TNFAIP3/MAP2K3/FOS/CCL20/BIRC3/JUNB/TNF	4.84493362477513
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	15/335	137/9376	3.06438609870356	NFKBIA/JUN/CTSD/CTSB/ATF4/CFLAR/GADD45B/FOS/CTSZ/PMAIP1/BIRC3/MCL1/APAF1/ERN1/TNF	4.68531218039275
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/335	70/9376	3.99829424307036	HLA-E/HLA-F/ITGB2/HLA-A/HLA-B/HLA-DRB1/HLA-DRA/HLA-C/HLA-G/HLA-DQA1	4.84664883419914
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/335	99/9376	3.3924920850294	C1QA/FCAR/ITGB2/C3AR1/C1QB/C1QC/HLA-DRB1/HLA-DRA/KRT19/KRT23/KRT18/HLA-DQA1	4.6064263920983
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	18/335	196/9376	2.57033201340238	PLCG2/HLA-E/NFKBIA/JUN/VEGFA/UBC/HLA-F/HLA-A/HLA-B/IRF7/ATG3/FOS/HLA-C/HLA-G/EIF2AK2/CDKN1A/CALM2/GNB2	4.27659364884869
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/335	50/9376	4.47808955223881	IL1B/ITGB2/HBA2/HBA1/TGFB1/MYD88/LRP1/TNF	4.7465478518615
NA	NA	hsa04518	Integrin signaling	15/335	154/9376	2.72610971118434	SPP1/FN1/TLN1/VEGFA/FLNA/FLT1/ITGB2/ITGA5/CCND3/ICAM3/ACTN4/COL4A1/PARVG/TGFB1/LAMA3	4.15734440922572
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	15/335	157/9376	2.67401844281776	SQSTM1/HLA-E/HLA-F/HLA-A/CCND3/HLA-B/SERPINE1/MAP2K3/GADD45B/HLA-C/HLA-G/TGFB1/CDKN1A/CALM2/SIRT1	4.07162679880349
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/335	94/9376	3.27519847570657	NFKBIA/JUN/FOSB/IL1B/HSP90AA1/TNFAIP3/FOS/HSP90AB1/JUND/CCL20/TNF	4.26738906426945
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/335	66/9376	3.81655359565807	JUN/IL1B/IL18RAP/HLA-DRB1/HLA-DRA/TGFB1/HLA-DQA1/STAT6/TNF	4.41992555055833
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	14/335	144/9376	2.72106135986733	NFKBIA/C1QA/IL1B/C3AR1/C1QB/C1QC/ALDH3A2/MAP2K3/CD14/MYD88/ALDH2/LPIN2/SIRT1/TNF	4.00617124549824
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	20/335	250/9376	2.2390447761194	SMAP2/HLA-E/HLA-F/EHD1/HLA-A/ACAP1/RAB11FIP1/HLA-B/IGF2R/DAB2/VPS37B/HLA-C/FOLR2/HLA-G/SPART/GRK2/GRK6/CYTH1/CBL/ARPC1B	3.82222791741204
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	18/335	214/9376	2.35413586274236	PLCG2/HLA-E/NFKBIA/JUN/HLA-F/HLA-A/HLA-B/TAPBP/MAP2K3/TAP1/FOS/HLA-C/HLA-G/MYD88/CALM2/TAP2/GNB2/TNF	3.85721449466096
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	15/335	163/9376	2.57558831608827	NFKBIA/JUN/ATF4/IRF7/GRB2/MAP2K3/FOS/IFIH1/TGFB1/STAT6/HSPG2/CDKN1A/MYD88/APAF1/TNF	3.90603225554141
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/335	56/9376	3.99829424307036	NFKBIA/NFKB2/IL1B/ITGB2/CD14/MYD88/APAF1/TNF	4.33171739677693
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/335	203/9376	2.3438276597309	SPP1/FN1/TLN1/JUN/VEGFA/FLNA/FLT1/ITGA5/CCND3/VASP/GRB2/ZYX/ACTN4/COL4A1/PARVG/BIRC3/LAMA3	3.7259386968566
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/335	138/9376	2.63655634869133	FN1/NFKBIA/JUN/IL1B/ITGA5/MAP2K3/FOS/ARHGEF1/RPS6KA1/MYD88/ARPC1B/BAIAP2/TNF	3.72804661904873
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/335	75/9376	3.3585671641791	CCND3/SERPINE1/GADD45B/SHISA5/CD82/PMAIP1/SESN2/CDKN1A/APAF1	3.94742479411941
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	19/335	248/9376	2.14424650938854	NFKBIA/JUN/FLNA/IL1B/HSP90AA1/MAP2K3/FOS/HSP90AB1/PLEKHM1/CD14/TUBB4B/BIRC3/GSDMD/MYD88/CYTH1/ARPC1B/CYFIP1/DYNC1LI1/TNF	3.51525980322235
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/335	91/9376	3.07561095620797	PLCG2/NFKBIA/JUN/LILRB3/NFKBIE/GRB2/LILRA2/FOS/INPP5D/LILRB2	3.82979478723081
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/335	93/9376	3.00946878510672	FN1/NFKBIA/RXRA/GADD45B/COL4A1/BIRC3/CDKN1A/CKS2/APAF1/LAMA3	3.74868001105398
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/335	37/9376	4.53860427591771	IL1B/HBA2/HBA1/PLCB2/MYD88/TNF	4.15128432301675
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/335	112/9376	2.74882729211087	NFKBIA/PPIF/HLA-DRB1/MAP2K3/HLA-DRA/TGFB1/BIRC3/HLA-DQA1/MYD88/TNF/LAMA3	3.58390482134609
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/335	362/9376	1.85556196915973	SPP1/FN1/VEGFA/FLT1/CSH1/ITGA5/ATF4/HSP90AA1/CCND3/DDIT4/GRB2/YWHAE/RXRA/IGF2/OSM/HSP90AB1/COL4A1/NR4A1/CSF1R/MCL1/CDKN1A/CRTC2/GNB2/LAMA3	3.1955586061938
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/335	169/9376	2.31853749006447	SQSTM1/UBC/ATG2A/CTSD/CTSB/CFLAR/DDIT4/ATG3/VMP1/PLEKHM1/PRKACA/ATG16L2/LAMP1/ERN1	3.32948122664858
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/335	100/9376	2.79880597014925	CCL3/CCL4/TNFSF14/IL18RAP/CCL3L1/TNFRSF14/CCL20/CSF1R/CCL4L2/TNF	3.48099786897187
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/335	101/9376	2.77109501994976	PLCG2/FN1/JUN/VEGFA/IL1B/SERPINE1/COL4A1/TGFB1/PLCB2/TNF	3.44465234406642
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	18/335	250/9376	2.01514029850746	PSAP/CTSD/CTSB/ATP6V1B2/BORCS5/IGF2R/GLA/HEXB/LGMN/MCOLN1/PLEKHM1/CTSZ/ATP6V0D1/CLN3/AP5Z1/SLC11A1/LAMTOR4/LAMP1	3.13152330232762
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/335	193/9376	2.17523780063414	PLCG2/NFKBIA/NCF1/CCL3/CCL4/FGR/CCL3L1/GRB2/CCL20/GRK2/PLCB2/PRKACA/GRK6/CCL4L2/GNB2	3.17549856780441
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/335	157/9376	2.31748265044206	DUSP2/C1QA/C1QB/ADAM17/STAB1/C1QC/RXRA/SCARF1/TGFB1/LRP1/SIRT1/PTGER4/BSG	3.20444358872725
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/335	88/9376	2.86241519674356	C1QA/ITGB2/PLAU/C3AR1/C1QB/C1QC/F13A1/SERPINE2/SERPINE1	3.37875379498059
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	10/335	105/9376	2.66552949538024	PLCG2/NFKBIA/PLK3/JUN/IRF1/NFKB2/LSP1/IL1B/CALM2/TNF	3.30356985281751
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/335	160/9376	2.27402985074627	HLA-E/HLA-F/ITGB2/HLA-A/HLA-B/ICAM3/HLA-DRB1/HLA-DRA/VSIR/HLA-C/HLA-G/HLA-DQA1/SIGLEC1	3.12873059539911
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/335	142/9376	2.3651881437881	SQSTM1/NCF1/JUN/VEGFA/IL1B/HSP90AA1/KLF2/IL1R2/FOS/HSP90AB1/CALM2/TNF	3.15530649995643
Human Diseases	Immune disease	hsa05310	Asthma	5/335	32/9376	4.37313432835821	PRG2/HLA-DRB1/HLA-DRA/HLA-DQA1/TNF	3.67910360426091
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/335	93/9376	2.70852190659605	JUN/ATF4/CGA/GRB2/MAP2K3/PLCB2/PRKACA/MAP3K3/CALM2	3.1872612140946
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/335	204/9376	2.05794556628622	PLCG2/FN1/VEGFA/FLNA/PLAU/ITGA5/GRB2/IGF2/ARHGEF1/TGFB1/HSPG2/CDKN1A/PRKACA/CBL/TNF	2.94066932020578
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/335	130/9376	2.36822043628014	NFKBIA/JUN/VEGFA/ATF4/GRB2/FOS/COL4A1/TGFB1/PLCB2/PRKACA/GNB2	3.02378293433679
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/335	100/9376	2.51892537313433	IL1B/ITGA5/HLA-DRB1/IL1R2/CD14/HLA-DRA/CSF1R/HLA-DQA1/TNF	2.93938094199742
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/335	37/9376	3.78217022993142	TPM3/NCOA4/RXRA/GADD45B/CDKN1A	3.26387998174306
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/335	52/9376	3.22939150401837	APOE/PLTP/APOC1/APOC2/CYP27A1/LRP1	3.10303510069327
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/335	298/9376	1.78447360512872	CCL3/LTB/CCL4/IL1B/CSH1/TNFSF14/IL1RN/IL18RAP/CCL3L1/TNFRSF14/IL1R2/OSM/CCL20/RELT/CSF1R/TGFB1/EBI3/CCL4L2/TNF	2.64905628276863
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	12/335	157/9376	2.13921475425421	JUN/IL1B/MT-CO3/ATF4/RXRA/MAP3K11/FOS/CEBPA/TGFB1/XBP1/ERN1/TNF	2.77085198368912
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	10/335	120/9376	2.33233830845771	PLCG2/NFKBIA/JUN/ATF4/NFKBIE/GRB2/YWHAE/RPS6KA1/MAP3K3/CALM2	2.82743918425988
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/335	103/9376	2.44555861469352	EIF4A3/FUS/DDX39B/RBM8A/PCF11/UPF1/PNN/PABPN1/NXF1	2.83951387884359
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/335	69/9376	2.83936837551374	JUN/FOSB/ATF4/FOS/PRKACA/CALM2/SIRT1	2.95180871642707
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/335	87/9376	2.57361468519472	JUN/RALGDS/GRB2/GADD45B/FOS/PMAIP1/TGFB1/CDKN1A	2.83839838989307
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/335	201/9376	1.9494170936363	FLT1/SPI1/PLAU/FUS/RXRA/GADD45B/IL1R2/CD14/CEBPA/CSF1R/BIRC3/CDKN1A/MLLT1/HPGD	2.61909858534064
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/335	106/9376	2.37634469163616	NFKBIA/PLAU/ATF4/HSP90AA1/GRB2/IL1R2/HSP90AB1/FOLR2/CDKN1A	2.74309017641935
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/335	93/9376	2.40757502808538	NFKBIA/JUN/NFKBIE/HLA-DRB1/FOS/HLA-DRA/HLA-DQA1/STAT6	2.62584241713521
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	17/335	275/9376	1.73017096336499	NCF1/PPIF/C1QA/IL1B/MT-CO3/MT-ATP6/MT-ND2/ATF4/C1QB/MT-ND1/C1QC/MT-ND5/MT-ATP8/TUBB4B/PRKACA/APAF1/TNF	2.36562638387943
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/335	133/9376	2.10436539108966	PLCG2/HLA-E/ITGB2/HLA-A/HLA-B/GRB2/HLA-C/HLA-G/LAT2/TNF	2.46906167976028
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/335	115/9376	2.19036988968202	NR4A2/ATF4/RXRA/FOS/JUND/ARHGEF1/PLCB2/CDKN1A/PRKACA	2.47230312646066
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/335	200/9376	1.81922388059702	NFKBIA/JUN/IL1B/MYO1F/FOS/ARHGEF1/TUBB4B/MYD88/CYTH1/ARPC1B/CYFIP1/BAIAP2/TNF	2.25419097195689
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/335	65/9376	2.5835132032147	ALDH3A2/GLA/DGKZ/PNPLA2/ALDH2/LPIN2	2.46592583661185
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/335	83/9376	2.36043877000539	NFKBIA/CCL4/IL1B/IRF7/ADAR/GSDMD/CCL4L2	2.39629281040644
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/335	122/9376	2.06469292879863	PLCG2/CSH1/ATF4/GRB2/MAP2K3/FOS/PLCB2/JUNB/PRKACA	2.2784491710925
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	16/335	268/9376	1.67092893740254	UBC/PPIF/MT-CO3/MT-ATP6/MT-ND2/ATF4/MT-ND1/MT-ND5/MT-ATP8/TUBB4B/XBP1/PRKACA/APAF1/CALM2/ERN1/MFN2	2.14502430109485
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/335	50/9376	2.79880597014925	AOC1/ALDH3A2/AMD1/LAP3/ALDH2	2.45483001092703
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	14/335	227/9376	1.72613584062069	NFKBIA/NCF1/JUN/VEGFA/PPIF/MT-CO3/MT-ATP6/MT-ND2/MT-ND1/GRB2/SOD2/FOS/MT-ND5/MT-ATP8	2.13178692938638
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/335	105/9376	2.13242359630419	SQSTM1/JUN/UBC/ATF4/TOMM40L/RABGEF1/FKBP8/MFN2	2.24615683105368
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/335	69/9376	2.43374432186892	CTSB/PLCB2/PRKACA/CALM2/KCNJ2/PTGER4	2.30086536376296
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	15/335	253/9376	1.65937112854699	PLCG2/SQSTM1/NFKBIA/TLN1/JUN/UBC/IL1B/ITGA5/ACTN4/CD14/PLCB2/MYD88/CYTH1/ARPC1B/TNF	2.04654433477359
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	21/335	388/9376	1.51481766425604	APOE/PPIF/ATG2A/IL1B/MT-CO3/MT-ATP6/MT-ND2/ATF4/MT-ND1/ADAM17/MT-ND5/MT-ATP8/TUBB4B/EIF2AK2/PLCB2/XBP1/LRP1/APAF1/CALM2/ERN1/TNF	1.9935979476178
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/335	70/9376	2.39897654584222	JUN/VEGFA/GRB2/TGFB1/CDKN1A/EGLN2	2.26140181559859
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	20/335	368/9376	1.52109020116807	SQSTM1/ATG2A/MT-CO3/MT-ATP6/MT-ND2/ATF4/FUS/MT-ND1/HNRNPA2B1/TOMM40L/SRSF3/MAP2K3/MT-ND5/MT-ATP8/TUBB4B/XBP1/APAF1/ERN1/TNF/NXF1	1.96300964854209
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/335	71/9376	2.3651881437881	PLCG2/NFKBIA/JUN/ATP6V1B2/ADAM17/ATP6V0D1	2.22261018751466
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/335	90/9376	2.17684908789386	NFKBIA/JUN/NFKBIE/MAP2K3/FOS/MYD88/MAP3K3	2.15937215681699
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/335	22/9376	3.81655359565807	AOC1/ALDH3A2/ALDH2	2.54583635781478
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/335	72/9376	2.33233830845771	NFKBIA/ISG15/IRF7/ADAR/IFIH1/TNF	2.18446816367977
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/335	38/9376	2.94611154752553	NADK/NAPRT/SIRT1/SIRT2	2.31383507518539
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/335	77/9376	2.18088776894747	VEGFA/RALGDS/GADD45B/RALBP1/TGFB1/CDKN1A	2.00279118038853
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/335	77/9376	2.18088776894747	NFKBIA/GRB2/GADD45B/TGFB1/CDKN1A/CBL	2.00279118038853
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/335	98/9376	1.99914712153518	PLCG2/ITPK1/PIP4P1/DGKZ/INPP5D/PLCB2/CALM2	1.91388175527659
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/335	98/9376	1.99914712153518	NR4A2/ATF4/NR4A1/PLCB2/PRKACA/CALM2/POMC	1.91388175527659
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/335	99/9376	1.97895371626715	PLCG2/IL1B/MAP2K3/PLCB2/PRKACA/CALM2/PTGER4	1.88484562330341
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/335	104/9376	1.88381171067738	MBOAT7/LPCAT1/DGKZ/PLD3/CRLS1/LPIN2/PHOSPHO1	1.7445744871635
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/335	168/9376	1.66595593461265	SQSTM1/IL1B/HSP90AA1/CFLAR/TNFAIP3/HSP90AB1/EIF2AK2/BIRC3/STAT6/TNF	1.6765529961155
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/335	65/9376	2.15292766934558	ATF4/NR4A1/PLCB2/PRKACA/POMC	1.79539654093966
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/335	238/9376	1.5287595635269	PLCG2/VEGFA/RALGDS/FLT1/GRB2/IGF2/RALBP1/CSF1R/ETS2/PRKACA/RGL2/CALM2/GNB2	1.59045338279978
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/335	217/9376	1.54772680376917	JUN/VEGFA/ATF4/HSP90AA1/CCND3/GRB2/RXRA/FOS/HSP90AB1/RPS6KA1/PRKACA/KLF5	1.57133809224136
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/335	30/9376	2.79880597014925	IL1B/FOLR2/TNF	1.89946749677421
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/335	67/9376	2.08866117175317	ATF4/RPS6KA1/PLCB2/PRKACA/CALM2	1.72138663571403
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	23/335	480/9376	1.34109452736318	SQSTM1/UBC/PPIF/ATG2A/IL1B/MT-CO3/MT-ATP6/MT-ND2/ATF4/FUS/MT-ND1/TOMM40L/MAP2K3/MT-ND5/MT-ATP8/TUBB4B/PLCB2/XBP1/APAF1/CALM2/ERN1/MFN2/TNF	1.47671875332571
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/335	68/9376	2.05794556628622	SPI1/GRB2/CD14/CEBPA/CSF1R	1.68534725869557
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/335	49/9376	2.28473956746878	JUN/FOSB/ATF4/PRKACA	1.73556929627366
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/335	89/9376	1.88683548549388	SPP1/FN1/ITGA5/COL4A1/HSPG2/LAMA3	1.61808059698313
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/335	69/9376	2.0281202682241	PLCG2/GRB2/MAP2K3/INPP5D/TNF	1.64992201109884
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/335	154/9376	1.6356658267106	JUN/RGS2/FOS/PLCB2/CDKN1A/PRKACA/CALM2/KCNJ2/EEF2	1.53100452056315
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/335	50/9376	2.2390447761194	HLA-DRB1/HLA-DRA/TGFB1/HLA-DQA1	1.69092406394887
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/335	133/9376	1.68349231287173	PLK3/GRB2/GADD45B/KLF2/SOD2/TGFB1/CDKN1A/SIRT1	1.5281035531702
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/335	70/9376	1.99914712153518	NFKBIA/NFKBIE/RXRA/TNF/POMC	1.61509006094845
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/335	32/9376	2.62388059701493	PMAIP1/BIRC3/APAF1	1.77117908028136
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/335	51/9376	2.19514193737196	PLCG2/ATP6V1B2/ATP6V0D1/PRKACA	1.64732754715871
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/335	16/9376	3.49850746268657	GLA/HEXB	1.92531823895095
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/335	33/9376	2.54436906377205	STX4/VAMP1/STX6	1.71066392138129
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/335	158/9376	1.59425656527489	ATP6V1B2/DDIT4/GRB2/SLC3A2/RPS6KA1/SESN2/LAMTOR4/LPIN2/TNF	1.45005337055591
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/335	205/9376	1.50179832544594	NCF1/PPIF/CTSD/MT-CO3/MT-ATP6/MT-ND2/MT-ND1/MT-ND5/MT-ATP8/TGFB1/PLCB2	1.39829111668182
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/335	73/9376	1.91699039051319	PLCG2/GRB2/RXRA/GADD45B/CDKN1A	1.51396038457561
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/335	138/9376	1.62249621457928	MT-CO3/MT-ATP6/MT-ND2/MT-ND1/ATP6V1B2/MT-ND5/MT-ATP8/ATP6V0D1	1.41803544374665
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/335	233/9376	1.44144513484082	FN1/TLN1/FMNL1/ITGA5/TPM3/ZYX/COL4A1/PLEC/HSPG2/DAAM2/DSP/VIM	1.3134397103727
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/335	76/9376	1.84131971720346	UBC/PLTP/RXRA/OLR1/CYP27A1	1.4175102114321
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/335	76/9376	1.84131971720346	PLCG2/GRB2/GADD45B/CDKN1A/CALM2	1.4175102114321
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/335	212/9376	1.45221064488876	TLN1/VEGFA/RALGDS/FLT1/ITGB2/VASP/MAP2K3/CSF1R/PLCB2/RGS14/CALM2	1.28193492197498
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/335	98/9376	1.71355467560158	PLCG2/NCF1/VASP/INPP5D/MARCKSL1/ARPC1B	1.36682501064293
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/335	143/9376	1.56576557770588	C1QA/C1QB/C1QC/HLA-DRB1/ACTN4/HLA-DRA/HLA-DQA1/TNF	1.31229939509494
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/335	78/9376	1.79410639112132	PLCG2/ITPK1/INPP5D/PLCB2/ISYNA1	1.35559834152759
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/335	38/9376	2.20958366064415	HEXB/AMDHD2/GNPDA1	1.43813806763965
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/335	59/9376	1.89749557298254	CGA/ABHD5/PNPLA2/PRKACA	1.33112880116005
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/335	174/9376	1.44765826042203	PPP1R15A/ERO1B/ATF4/HSP90AA1/HSP90AB1/DNAJB1/DNAJA1/XBP1/ERN1	1.14730772958789
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/335	21/9376	2.66552949538024	ALDH3A2/ALDH2	1.47075348689943
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/335	41/9376	2.04790680742628	VEGFA/TYMP/CDKN1A	1.29436641559495
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/335	107/9376	1.56942390849491	ATF4/PLCB2/PRKACA/CALM2/CRTC2/SIRT1	1.14027854486677
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/335	42/9376	1.99914712153518	AOC1/ALDH3A2/ALDH2	1.24916554135647
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/335	108/9376	1.55489220563847	EIF4A3/DDX39B/RBM8A/UPF1/PNN/NXF1	1.11641919989467
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/335	86/9376	1.62721277334259	PLCG2/JUN/GRB2/CDKN1A/CBL	1.12475017653461
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/335	23/9376	2.43374432186892	GLS/ASL	1.32513452399567
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/335	110/9376	1.52662143826323	PLCG2/VEGFA/FLT1/SERPINE1/CDKN1A/EGLN2	1.06942057792038
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/335	65/9376	1.72234213547646	SPP1/CGA/PLCB2/GABBR1	1.12486724526747
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/335	44/9376	1.90827679782904	HEXB/MGAT1/MAN2A2	1.1624037448701
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/335	44/9376	1.90827679782904	STX4/PRKACA/DYNC1LI1	1.1624037448701
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/335	89/9376	1.57236290457823	SLC38A2/GABBR1/PRKACA/GLS/GNB2	1.04430790770081
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/335	308/9376	1.27218453188602	PPIF/ATG2A/MT-CO3/MT-ATP6/MT-ND2/MT-ND1/SOD2/MT-ND5/MT-ATP8/TUBB4B/POLR2A/PLCB2/APAF1/ERN1	0.93493808323494
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/335	90/9376	1.55489220563847	ATF4/SOD2/SESN2/PRKACA/SIRT1	1.01815839534266
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	11/335	235/9376	1.31007939028263	MT-CO3/MT-ATP6/MT-ND2/MT-ND1/GRB2/MAP2K3/MT-ND5/MT-ATP8/RPS6KA1/PNPLA2/PRKACA	0.926637315492516
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/335	91/9376	1.53780547810399	GRK2/GABBR1/PRKACA/GRK6/GNB2	0.992326914842342
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/335	115/9376	1.46024659312135	ATF4/FOS/PLCB2/PRKACA/KCNJ2/GNB2	0.955895390987023
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/335	140/9376	1.39940298507463	SPP1/SERPINE1/KLF2/PLCB2/PRKACA/CALM2/GNB2	0.916501477034473
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/335	116/9376	1.44765826042203	SLC38A2/GRK2/PLCB2/PRKACA/GLS/GNB2	0.933834492340032
NA	NA	hsa03272	Virion - Hepatitis viruses	3/335	48/9376	1.74925373134328	TGOLN2/HSPG2/LAMP1	1.00174012869852
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/335	71/9376	1.57679209585873	IRF1/CGA/GRB2/FOS	0.939052975347651
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/335	73/9376	1.53359231241055	MX1/AFF4/MX2/MLLT1	0.880966290226405
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/335	28/9376	1.99914712153518	ATP6V1B2/ATP6V0D1	1.01917535299771
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/335	97/9376	1.44268348976766	FOS/PLCB2/PRKACA/CALM2/GNB2	0.843584151075442
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/335	122/9376	1.37646195253242	NFKBIA/JUN/NFKBIE/GRB2/FOS/TNF	0.805630807244317
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/335	99/9376	1.41353836876225	JUN/GRB2/FOS/CDKN1A/PRKACA	0.796213315785452
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/335	99/9376	1.41353836876225	JUN/RALGDS/GRB2/FOS/DGKZ	0.796213315785452
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/335	75/9376	1.49269651741294	PMAIP1/BIRC3/CDKN1A/APAF1	0.824603377147845
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/335	75/9376	1.49269651741294	ATF4/CGA/PLCB2/PRKACA	0.824603377147845
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/335	52/9376	1.61469575200918	CGA/PRKACA/HSD17B1	0.855579870692748
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/335	76/9376	1.47305577376276	PLCB2/PRKACA/CALM2/KCNJ2	0.797035153430821
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/335	226/9376	1.23840972130498	NFKBIA/JUN/CGA/FOS/FFAR2/HCAR2/GABBR1/PRKACA/CALM2/POMC	0.698340837958493
Organismal Systems	Immune system	hsa04611	Platelet activation	6/335	126/9376	1.33276474769012	PLCG2/TLN1/VASP/ARHGEF1/PLCB2/PRKACA	0.723854910984342
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/335	78/9376	1.43528511289705	FN1/ITGA5/CBL/ARPC1B	0.743063881278788
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/335	31/9376	1.80568127106403	ALDH3A2/ALDH2	0.864876843404708
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/335	31/9376	1.80568127106403	ALDH3A2/ALDH2	0.864876843404708
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/335	55/9376	1.52662143826323	PSAP/GLA/HEXB	0.753960220379416
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/335	32/9376	1.74925373134328	ATG2A/ATG3	0.817216818291583
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/335	105/9376	1.33276474769012	ITGA5/TPM3/TGFB1/PRKACA/TNF	0.660037298407937
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/335	158/9376	1.23997732854714	CCND3/PRKDC/YWHAE/GADD45B/TGFB1/CDKN1A/CDKN1C	0.585571879977147
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/335	133/9376	1.2626192346538	ATF4/FOS/PLCB2/PRKACA/CALM2/GNB2	0.587145426580123
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/335	34/9376	1.64635645302897	POLR2A/CRCP	0.726760680964152
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/335	59/9376	1.42312167973691	GRB2/GADD45B/CDKN1A	0.62755680501164
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/335	110/9376	1.27218453188602	HSP90AA1/HSP90AB1/RPS6KA1/PRKACA/AURKA	0.55273051615693
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/335	138/9376	1.21687216093446	YWHAE/RPS6KA1/REC8/PRKACA/AURKA/CALM2	0.494030973625823
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/335	138/9376	1.21687216093446	FLOT1/GRB2/FLOT2/PRKACA/CBL/CALM2	0.494030973625823
NA	NA	hsa04382	Cornified envelope formation	9/335	217/9376	1.16079510282688	KRT7/COL4A1/PLEC/KRT19/KRT23/KRT18/ABHD5/DSP/LAMA3	0.461294697245128
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/335	13/9376	2.15292766934558	PRKDC	0.800693003414787
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/335	166/9376	1.1802193850027	PPIF/ATF4/RGS2/VASP/PLCB2/CALM2/GTF2I	0.450947038722641
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/335	62/9376	1.35426095329803	SOD2/PRKACA/SIRT1	0.538704771181848
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/335	37/9376	1.51286809197257	GLS/ASL	0.601666957922014
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/335	89/9376	1.25789032366259	GRB2/TUBB4B/PLCB2/PRKACA	0.470535218418488
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/335	168/9376	1.16616915422886	CSH1/CCND3/GRB2/OSM/MCL1/STAT6/CDKN1A	0.418333074164145
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/335	38/9376	1.47305577376276	TAP1/TAP2	0.562441060093905
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/335	116/9376	1.20638188368502	PLCG2/NCF1/ITGB2/VASP/ACTN4	0.430521535328067
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/335	15/9376	1.86587064676617	HEXB	0.646007159542251
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/335	148/9376	1.13465106897943	JUN/NFKB2/GRB2/GADD45B/FOS/CDKN1A	0.317823991395686
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/335	149/9376	1.12703596113393	PLCG2/RALGDS/GRB2/DGKZ/PLCB2/CYTH1	0.300877255353918
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/335	149/9376	1.12703596113393	MT-ND2/MT-ND1/MT-ND5/PLCB2/PRKACA/GNB2	0.300877255353918
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/335	42/9376	1.33276474769012	NCOA4/SLC3A2	0.416033081848839
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/335	178/9376	1.10065403320476	JUN/NOTUM/CCND3/PLCB2/DAAM2/PRKACA/SIRT1	0.260972224449126
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/335	43/9376	1.30177021867407	ALDH3A2/ALDH2	0.381768225707109
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/335	17/9376	1.64635645302897	CYP27A1	0.513430463469904
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/335	17/9376	1.64635645302897	LAMP1	0.513430463469904
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/335	154/9376	1.09044388447374	ATF4/TPM3/PLCB2/PRKACA/KCNE1/CALM2	0.217834576231861
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/335	99/9376	1.1308306950098	ITGA5/TPM3/TGFB1/TNF	0.251897162026473
NA	NA	hsa04519	Cadherin signaling	15/335	404/9376	1.03916063248116	NFKBIA/MYO1F/KRT7/VASP/YWHAE/MAP2K3/ACTN4/KRT19/KRT23/KRT18/DAAM2/DSP/VIM/ARPC1B/CYFIP1	0.154880076562089
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/335	155/9376	1.08340876263842	ATF4/NR4A1/PLCB2/CDKN1A/PRKACA/POMC	0.20155256233
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/335	18/9376	1.55489220563847	HEXB	0.453579234482393
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/335	18/9376	1.55489220563847	PRDX1	0.453579234482393
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/335	45/9376	1.24391376451078	TAP1/TAP2	0.315702687046329
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/335	101/9376	1.1084380079799	PLCB2/PRKACA/CALM2/POMC	0.2109041209909
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/335	157/9376	1.0696073771271	ITGB2/CCND3/YWHAE/SERPINE1/TGFB1/BIRC3	0.169302353460385
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/335	19/9376	1.47305577376276	HEXB	0.397301898526516
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/335	47/9376	1.1909812638933	ALDH3A2/ALDH2	0.252651541683929
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/335	103/9376	1.08691493986379	COL4A1/SLC3A2/SLC38A2/COL18A1	0.170727202282563
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/335	48/9376	1.16616915422886	ALDH3A2/ALDH2	0.222165473429817
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/335	134/9376	1.04433058587659	ARHGEF1/PLCB2/PRKACA/CALM2/ADM	0.0994884569764801
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/335	78/9376	1.07646383467279	EXOSC4/CNOT3/TOB2	0.130529421029982
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/335	79/9376	1.06283771018326	ATP6V1B2/NAPA/ATP6V0D1	0.107959853898037
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/335	51/9376	1.09757096868598	LPCAT1/PLD3	0.134487243308368
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/335	80/9376	1.04955223880597	PLCG2/VEGFA/GRB2	0.0856761660886494
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/335	195/9376	1.00469957902794	PLCG2/NCF1/PPIF/ITGB2/PADI4/GSDMD/PLCB2	0.0127653014829934
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/335	109/9376	1.0270847596878	NFKBIA/RPS6KA1/CRTC2/TNF	0.0547480255391816
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/335	23/9376	1.21687216093446	GLS	0.200443540291189
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/335	53/9376	1.05615319628274	PLCB2/PRKACA	0.0789104248229697
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/335	170/9376	0.987813871817384	PLCG2/GRB2/GADD45B/IGF2/TGFB1/CDKN1A	-0.0308641644669763
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/335	83/9376	1.0116166157166	PHC2/FBRS/PHF1	0.0204616432114965
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/335	144/9376	0.971807628524046	PPIF/ATG2A/PLCB2/XBP1/ERN1	-0.0656243121733187
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/335	232/9376	0.965105506948019	FN1/ITGB2/ITGA5/ACTN4/ARHGEF1/ARPC1B/CYFIP1/BAIAP2	-0.103593518550046
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/335	86/9376	0.976327664005554	PLCB2/GABBR1/PRKACA	-0.0424504493855344
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/335	86/9376	0.976327664005554	ATF4/PLCB2/PRKACA	-0.0424504493855344
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/335	56/9376	0.999573560767591	MGAT1/MAN2A2	-0.000616088379572931
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/335	56/9376	0.999573560767591	GRK2/PRKACA	-0.000616088379572931
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/335	323/9376	0.953153735964142	PLCG2/VEGFA/PLAU/ITGA5/DDIT4/GRB2/MCL1/CDKN1A/VIM/GLS/SIRT1	-0.164922447002958
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/335	150/9376	0.932935323383084	GRB2/RXRA/GADD45B/TGFB1/CDKN1A	-0.15937953164503
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/335	59/9376	0.948747786491272	TYMP/CMPK2	-0.076015191136768
NA	NA	hsa04517	IgSF CAM signaling	10/335	299/9376	0.936055508411122	PLCG2/ITGB2/ITGA5/ICAM3/GRB2/ACTN4/TUBB4B/INPP5D/ARPC1B/BAIAP2	-0.21630540530361
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/335	60/9376	0.932935323383084	PLCG2/VEGFA	-0.100312378286401
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/335	122/9376	0.91764130168828	PLCG2/RXRA/PLCB2/PRKACA	-0.176248101987805
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/335	243/9376	0.921417603341318	EIF4A3/CWC25/FUS/SRSF3/DDX39B/RBM8A/RBM25/HNRNPU	-0.23890293495768
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/335	154/9376	0.908703237061446	ALDH3A2/NADK/NAPRT/CMPK2/ALDH2	-0.219888738545235
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/335	93/9376	0.902840635532017	ACTN4/CCM2/BAIAP2	-0.181251567661695
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/335	93/9376	0.902840635532017	PLCB2/PRKACA/CALM2	-0.181251567661695
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/335	29/9376	0.965105506948019	CALM2	-0.0362259328676846
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/335	63/9376	0.888509831793414	ALDH3A2/ALDH2	-0.170907787111054
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/335	63/9376	0.888509831793414	GADD45B/CDKN1A	-0.170907787111054
NA	NA	hsa04081	Hormone signaling	7/335	219/9376	0.894595515572821	CSH1/CGA/IGF2/PLCB2/PRKACA/GNB2/POMC	-0.303811595691734
NA	NA	hsa04981	Folate transport and metabolism	1/335	31/9376	0.902840635532017	FOLR2	-0.104297924584122
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/335	191/9376	0.879206063921231	FOSB/ATF4/GRB2/PRKACA/CALM2/GNB2	-0.324654960827772
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/335	32/9376	0.874626865671642	GLA	-0.136745443698193
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	8/335	254/9376	0.881513691385592	PLCG2/VEGFA/PPIF/FLT1/MCOLN1/PLCB2/PRKACA/CALM2	-0.368501958946903
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/335	67/9376	0.83546446870127	ALDH3A2/ALDH2	-0.260162915723016
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/335	170/9376	0.823178226514486	JUN/VASP/ACTN4/PRKACA/ARPC1B	-0.447841694787392
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/335	73/9376	0.766796156205275	GADD45B/CDKN1A	-0.385021898472004
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/335	142/9376	0.788396047929367	UBC/UBE2S/BIRC3/CBL	-0.489072021627936
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/335	110/9376	0.763310719131615	EMP3/TGFB1/TNF	-0.480649607369965
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/335	115/9376	0.730123296560675	PLCB2/PRKACA/GNB2	-0.56051234448661
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/335	44/9376	0.636092265943012	GTF2I	-0.465725551798867
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/335	83/9376	0.674411077144399	SOD2/PRDX1	-0.57349614858724
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/335	85/9376	0.658542581211589	TYMP/CMPK2	-0.608715825714357
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/335	46/9376	0.608436080467229	HMOX2	-0.512437104048713
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/335	46/9376	0.608436080467229	PSMB8	-0.512437104048713
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/335	122/9376	0.68823097626621	CRTC2/SIRT1/EEF2	-0.667187556603866
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/335	86/9376	0.650885109337036	ITGA5/DSP	-0.626050762345608
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/335	47/9376	0.59549063194665	TNF	-0.535130584963401
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/335	87/9376	0.643403671298679	MT-CO3/TPM3	-0.643208566080691
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/335	48/9376	0.583084577114428	PLCB2	-0.557409181838883
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/335	125/9376	0.671713432835821	CTSD/PLCB2/TNF	-0.711235762421297
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/335	90/9376	0.62195688225539	RXRA/PRKACA	-0.693662246868835
NA	NA	hsa04082	Neuroactive ligand signaling	5/335	199/9376	0.703217580439511	PLCB2/GABBR1/PRKACA/GNB2/POMC	-0.814543252829943
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/335	54/9376	0.518297401879491	AMD1	-0.683315270738335
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/335	59/9376	0.474373893245636	LAP3	-0.779587187285176
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/335	60/9376	0.466467661691542	PLCB2	-0.798034083637513
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/335	61/9376	0.45882065084414	HMOX2	-0.816233680061015
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/335	62/9376	0.451420317766009	ADAM17	-0.834194368421579
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/335	63/9376	0.444254915896707	HPGD	-0.851924111783067
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/335	63/9376	0.444254915896707	POLR2A	-0.851924111783067
Genetic Information Processing	Translation	hsa03010	Ribosome	5/335	222/9376	0.630361704988571	RPS9/RPLP0/RPS2/RPS4Y1/RPL36A	-1.07287172204809
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/335	66/9376	0.424061510628675	HSD17B1	-0.90380145744307
Cellular Processes	Cell motility	hsa04814	Motor proteins	4/335	194/9376	0.577073395907063	MYO1F/TPM3/TUBB4B/DYNC1LI1	-1.14576890836463
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/335	71/9376	0.394198023964684	GLS	-0.986282842902858
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/335	117/9376	0.478428370965684	CHD4/BAZ2A	-1.09275966360132
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/335	75/9376	0.373174129353234	ASL	-1.04908947303509
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/335	82/9376	0.341317801237714	TYMP	-1.15313811113165
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/335	370/9376	0.605147236789028	CSH1/C3AR1/CGA/LTB4R/GABBR1/PTGER4/ADM/POMC	-1.49166012178189
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/335	144/9376	0.388723051409619	GRB2/DUSP9	-1.42288949806384
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/335	102/9376	0.274392742171495	PLCB2	-1.41829955054069
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/335	183/9376	0.152940216948047	NXF1	-2.22746446583113
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/335	184/9376	0.152109020116807	PLCG2	-2.23585546694161
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/335	449/9376	0.249336834757172	RGS2/GRK2/PRKACA/CALM2	-3.13772816405224