ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003725 double-stranded RNA binding 18/555 75/18639 0.24 8.06010810810811 5.10080519276108e-12 4.47850695924423e-09 GO:0042605 peptide antigen binding 12/555 45/18639 0.266666666666667 8.95567567567567 5.06524973439873e-09 2.22364463340104e-06 GO:0042277 peptide binding 25/555 249/18639 0.100401606425703 3.37186584174536 1.22262666485285e-07 3.57822070580267e-05 GO:0038024 cargo receptor activity 12/555 65/18639 0.184615384615385 6.20008316008316 4.12345160676775e-07 9.05097627685522e-05 GO:0023023 MHC protein complex binding 9/555 37/18639 0.243243243243243 8.16902848794741 1.01901894919627e-06 0.000178939727478865 GO:0005126 cytokine receptor binding 24/555 275/18639 0.0872727272727273 2.9309484029484 2.73711537286874e-06 0.000400531216229793 GO:0030228 lipoprotein particle receptor activity 6/555 18/18639 0.333333333333333 11.1945945945946 9.27968442450391e-06 0.00115955979973873 GO:0023026 MHC class II protein complex binding 7/555 27/18639 0.259259259259259 8.70690690690691 1.05654651456831e-05 0.00115955979973873 GO:0140313 molecular sequestering activity 9/555 55/18639 0.163636363636364 5.49552825552826 3.23329626780892e-05 0.00315426013681804 GO:0097110 scaffold protein binding 10/555 70/18639 0.142857142857143 4.7976833976834 4.02294820693655e-05 0.00347432948525759 GO:0140311 protein sequestering activity 7/555 33/18639 0.212121212121212 7.12383292383292 4.35280459428627e-05 0.00347432948525759 GO:0005041 low-density lipoprotein particle receptor activity 5/555 15/18639 0.333333333333333 11.1945945945946 5.38857520427421e-05 0.00394264085779396 GO:0031720 haptoglobin binding 4/555 10/18639 0.4 13.4335135135135 0.000141550197158193 0.00956008254653025 GO:0140297 DNA-binding transcription factor binding 30/555 488/18639 0.0614754098360656 2.06457687195392 0.000155810979079932 0.00977157425944148 GO:0042287 MHC protein binding 7/555 41/18639 0.170731707317073 5.73381674357284 0.000186410331204664 0.0109112180531796 GO:0042608 T cell receptor binding 4/555 11/18639 0.363636363636364 12.212285012285 0.000217205325745674 0.0119191422502938 GO:0042288 MHC class I protein binding 5/555 20/18639 0.25 8.39594594594595 0.000245890099570285 0.01269950043663 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 23/555 349/18639 0.0659025787965616 2.2132579570975 0.000340438344230006 0.0166058259018858 GO:0045296 cadherin binding 22/555 334/18639 0.0658682634730539 2.21210551869235 0.000458035970000174 0.0211660832452712 GO:0051015 actin filament binding 16/555 209/18639 0.076555023923445 2.57100737100737 0.000545226782731371 0.0239354557619072 GO:0005344 oxygen carrier activity 4/555 14/18639 0.285714285714286 9.59536679536679 0.000613549860038007 0.025652227481589 GO:0003713 transcription coactivator activity 18/555 256/18639 0.0703125 2.3613597972973 0.000694976459746029 0.0277358787116824 GO:0003823 antigen binding 14/555 174/18639 0.0804597701149425 2.70214352283318 0.000731245552272175 0.0279145041258683 GO:0140375 immune receptor activity 13/555 156/18639 0.0833333333333333 2.79864864864865 0.000807654921391004 0.028774485257577 GO:0016922 nuclear receptor binding 12/555 137/18639 0.0875912408759124 2.94164529492997 0.000819319056309141 0.028774485257577 GO:0051082 unfolded protein binding 11/555 121/18639 0.0909090909090909 3.05307125307125 0.000983439827397977 0.0332100064790547 GO:0016209 antioxidant activity 9/555 86/18639 0.104651162790698 3.51458202388435 0.00103495412052406 0.0333149391106638 GO:0005178 integrin binding 13/555 161/18639 0.0807453416149068 2.71173409434279 0.00108186461763057 0.0333149391106638 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 6/555 40/18639 0.15 5.03756756756757 0.00110037953782375 0.0333149391106638 GO:0030169 low-density lipoprotein particle binding 4/555 17/18639 0.235294117647059 7.90206677265501 0.00135877654203724 0.0375738428635043 GO:0070403 NAD+ binding 4/555 17/18639 0.235294117647059 7.90206677265501 0.00135877654203724 0.0375738428635043 GO:0035198 miRNA binding 6/555 42/18639 0.142857142857143 4.7976833976834 0.00143023410835879 0.0375738428635043 GO:0004601 peroxidase activity 7/555 57/18639 0.12280701754386 4.12432432432432 0.0014550235277439 0.0375738428635043 GO:0016504 peptidase activator activity 7/555 57/18639 0.12280701754386 4.12432432432432 0.0014550235277439 0.0375738428635043 GO:0061980 regulatory RNA binding 7/555 58/18639 0.120689655172414 4.05321528424977 0.00161305175757772 0.039437440014607 GO:0048156 tau protein binding 6/555 43/18639 0.13953488372093 4.68610936517913 0.00162100705372348 0.039437440014607 GO:0044389 ubiquitin-like protein ligase binding 20/555 322/18639 0.062111801242236 2.08594930334061 0.0016619422329618 0.039437440014607 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/555 59/18639 0.11864406779661 3.98451672010994 0.00178411560068712 0.0412224604579813 GO:0031625 ubiquitin protein ligase binding 19/555 302/18639 0.0629139072847682 2.11288705924468 0.00185724126025196 0.041811739141057 GO:0140674 ATP-dependent histone chaperone activity 12/555 152/18639 0.0789473684210526 2.65135135135135 0.00200870667160943 0.0430038538544655 GO:0016411 acylglycerol O-acyltransferase activity 5/555 31/18639 0.161290322580645 5.41673931996513 0.00205713196114755 0.0430038538544655 GO:0070325 lipoprotein particle receptor binding 5/555 31/18639 0.161290322580645 5.41673931996513 0.00205713196114755 0.0430038538544655 GO:0071813 lipoprotein particle binding 5/555 32/18639 0.15625 5.24746621621622 0.00237924197397632 0.0474766921170729 GO:0071814 protein-lipid complex binding 5/555 32/18639 0.15625 5.24746621621622 0.00237924197397632 0.0474766921170729 GO:0019838 growth factor binding 11/555 136/18639 0.0808823529411765 2.71633545310016 0.00251988403900476 0.0491657374721373 GO:0032395 MHC class II receptor activity 3/555 10/18639 0.3 10.0751351351351 0.00269477373059331 0.0514350290317593 GO:0140658 ATP-dependent chromatin remodeler activity 12/555 158/18639 0.0759493670886076 2.55066712281902 0.00277239022554485 0.0517906088942207 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 6/555 48/18639 0.125 4.19797297297297 0.00287913894634647 0.0526642498935875 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/555 21/18639 0.19047619047619 6.3969111969112 0.00310928914093838 0.0549801663601762 GO:0019825 oxygen binding 5/555 34/18639 0.147058823529412 4.93879173290938 0.00313098897267518 0.0549801663601762 GO:0001540 amyloid-beta binding 8/555 83/18639 0.0963855421686747 3.23699120807555 0.00327186456999074 0.0563273939696445 GO:0140104 molecular carrier activity 16/555 249/18639 0.0642570281124498 2.15799413871703 0.00334776127352611 0.0565256615029986 GO:0032813 tumor necrosis factor receptor superfamily binding 6/555 50/18639 0.12 4.03005405405405 0.00354665138878893 0.0578500133228548 GO:0005114 type II transforming growth factor beta receptor binding 3/555 11/18639 0.272727272727273 9.15921375921376 0.00362386188241118 0.0578500133228548 GO:0034713 type I transforming growth factor beta receptor binding 3/555 11/18639 0.272727272727273 9.15921375921376 0.00362386188241118 0.0578500133228548 GO:0003779 actin binding 24/555 443/18639 0.054176072234763 1.81943749618693 0.00369321842902229 0.0578665674761087 GO:0140713 histone chaperone activity 12/555 164/18639 0.0731707317073171 2.45735003295979 0.00375671337828952 0.0578665674761087 GO:0003712 transcription coregulator activity 26/555 495/18639 0.0525252525252525 1.76399672399672 0.00387758237056156 0.0586985745060871 GO:0019887 protein kinase regulator activity 16/555 255/18639 0.0627450980392157 2.10721780604134 0.00421693997843246 0.0627537847637915 GO:0042171 lysophosphatidic acid acyltransferase activity 4/555 23/18639 0.173913043478261 5.8406580493537 0.00438899132591182 0.0631726948221407 GO:0071617 lysophospholipid acyltransferase activity 4/555 23/18639 0.173913043478261 5.8406580493537 0.00438899132591182 0.0631726948221407 GO:0043394 proteoglycan binding 5/555 37/18639 0.135135135135135 4.53834915997078 0.00455926382345628 0.0645650586612034 GO:0035259 nuclear glucocorticoid receptor binding 3/555 12/18639 0.25 8.39594594594595 0.00472576446487281 0.0658606539707671 GO:0060229 lipase activator activity 4/555 24/18639 0.166666666666667 5.5972972972973 0.00514460865355319 0.0705775999659328 GO:0000510 H3-H4 histone complex chaperone activity 11/555 151/18639 0.0728476821192053 2.4465008054412 0.0055919526180147 0.0722019764502486 GO:0140584 chromatin extrusion motor activity 11/555 151/18639 0.0728476821192053 2.4465008054412 0.0055919526180147 0.0722019764502486 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 11/555 151/18639 0.0728476821192053 2.4465008054412 0.0055919526180147 0.0722019764502486 GO:0140849 ATP-dependent H2AZ histone chaperone activity 11/555 151/18639 0.0728476821192053 2.4465008054412 0.0055919526180147 0.0722019764502486 GO:0019207 kinase regulator activity 17/555 287/18639 0.0592334494773519 1.98928336001507 0.00574817211638072 0.0722709763138673 GO:0015616 DNA translocase activity 11/555 152/18639 0.0723684210526316 2.43040540540541 0.00587149662801795 0.0722709763138673 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/555 13/18639 0.230769230769231 7.75010395010395 0.00600886249534432 0.0722709763138673 GO:0005172 vascular endothelial growth factor receptor binding 3/555 13/18639 0.230769230769231 7.75010395010395 0.00600886249534432 0.0722709763138673 GO:0032396 inhibitory MHC class I receptor activity 3/555 13/18639 0.230769230769231 7.75010395010395 0.00600886249534432 0.0722709763138673 GO:0061775 cohesin loader activity 11/555 153/18639 0.0718954248366013 2.4145204027557 0.00616192166291733 0.0731103678383975 GO:0004532 RNA exonuclease activity 5/555 40/18639 0.125 4.19797297297297 0.00639874211670427 0.0749079410462179 GO:0008157 protein phosphatase 1 binding 4/555 26/18639 0.153846153846154 5.16673596673597 0.00690669572328631 0.077838888969763 GO:0050750 low-density lipoprotein particle receptor binding 4/555 26/18639 0.153846153846154 5.16673596673597 0.00690669572328631 0.077838888969763 GO:0044183 protein folding chaperone 7/555 75/18639 0.0933333333333333 3.13448648648649 0.00691507214082177 0.077838888969763 GO:0001221 transcription coregulator binding 9/555 115/18639 0.0782608695652174 2.62829612220917 0.00744060331160242 0.0820964175698094 GO:0005161 platelet-derived growth factor receptor binding 3/555 14/18639 0.214285714285714 7.1965250965251 0.00748031139588241 0.0820964175698094 GO:0005044 scavenger receptor activity 4/555 27/18639 0.148148148148148 4.97537537537537 0.00792039050829855 0.0850370238151974 GO:0003724 RNA helicase activity 7/555 77/18639 0.0909090909090909 3.05307125307125 0.00796544005089973 0.0850370238151974 GO:0045309 protein phosphorylated amino acid binding 6/555 59/18639 0.101694915254237 3.41530004580852 0.00803880749050272 0.0850370238151974 GO:0003689 DNA clamp loader activity 11/555 160/18639 0.06875 2.30888513513514 0.0085237197778965 0.0890931662499181 GO:0030295 protein kinase activator activity 10/555 139/18639 0.0719424460431655 2.4160995527902 0.00876098853768517 0.0904958580716186 GO:0008186 ATP-dependent activity, acting on RNA 7/555 79/18639 0.0886075949367089 2.97577830995552 0.00912895299093262 0.0912533658087899 GO:0046332 SMAD binding 7/555 79/18639 0.0886075949367089 2.97577830995552 0.00912895299093262 0.0912533658087899 GO:0004953 icosanoid receptor activity 3/555 15/18639 0.2 6.71675675675676 0.0091461232245712 0.0912533658087899 GO:0004540 RNA nuclease activity 9/555 121/18639 0.0743801652892562 2.49796738887648 0.0102357352715555 0.100977253577817 GO:0005125 cytokine activity 14/555 234/18639 0.0598290598290598 2.00928620928621 0.0106541337539782 0.102408919284345 GO:0140597 protein carrier chaperone 12/555 188/18639 0.0638297872340425 2.14364577343301 0.0108133286159998 0.102408919284345 GO:0005149 interleukin-1 receptor binding 3/555 16/18639 0.1875 6.29695945945946 0.0110112446168234 0.102408919284345 GO:0055102 lipase inhibitor activity 3/555 16/18639 0.1875 6.29695945945946 0.0110112446168234 0.102408919284345 GO:0019903 protein phosphatase binding 10/555 144/18639 0.0694444444444444 2.33220720720721 0.0110806917221103 0.102408919284345 GO:0019955 cytokine binding 10/555 144/18639 0.0694444444444444 2.33220720720721 0.0110806917221103 0.102408919284345 GO:0001965 G-protein alpha-subunit binding 4/555 30/18639 0.133333333333333 4.47783783783784 0.0115315903772459 0.105466003658562 GO:0140098 catalytic activity, acting on RNA 20/555 387/18639 0.0516795865633075 1.73559606117746 0.0124070309498162 0.11149432714215 GO:0001216 DNA-binding transcription activator activity 24/555 491/18639 0.0488798370672098 1.64156987945175 0.0124808008036903 0.11149432714215 GO:0001784 phosphotyrosine residue binding 5/555 47/18639 0.106382978723404 3.57274295572168 0.0125933395065537 0.11149432714215 GO:0120013 lipid transfer activity 6/555 65/18639 0.0923076923076923 3.10004158004158 0.0127026114224078 0.11149432714215 GO:0005092 GDP-dissociation inhibitor activity 3/555 17/18639 0.176470588235294 5.92655007949126 0.013079630632849 0.11149432714215 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/555 17/18639 0.176470588235294 5.92655007949126 0.013079630632849 0.11149432714215 GO:1990226 histone methyltransferase binding 3/555 17/18639 0.176470588235294 5.92655007949126 0.013079630632849 0.11149432714215 GO:0019209 kinase activator activity 10/555 148/18639 0.0675675675675676 2.26917457998539 0.0132497606797238 0.111858556507668 GO:0140693 molecular condensate scaffold activity 5/555 48/18639 0.104166666666667 3.49831081081081 0.0137228977112289 0.114749563718657 GO:0019888 protein phosphatase regulator activity 8/555 107/18639 0.0747663551401869 2.51093710532963 0.014624315484829 0.121133481091319 GO:0003746 translation elongation factor activity 3/555 18/18639 0.166666666666667 5.5972972972973 0.0153543146992325 0.12367970922868 GO:0032393 MHC class I receptor activity 3/555 18/18639 0.166666666666667 5.5972972972973 0.0153543146992325 0.12367970922868 GO:0098641 cadherin binding involved in cell-cell adhesion 3/555 18/18639 0.166666666666667 5.5972972972973 0.0153543146992325 0.12367970922868 GO:1990841 promoter-specific chromatin binding 6/555 68/18639 0.0882352941176471 2.96327503974563 0.015631345658638 0.124766558984402 GO:0048020 CCR chemokine receptor binding 5/555 50/18639 0.1 3.35837837837838 0.0161822476506483 0.128000121056479 GO:0031072 heat shock protein binding 9/555 131/18639 0.0687022900763359 2.30728285537446 0.0165549833142459 0.129779244195606 GO:0030544 Hsp70 protein binding 5/555 51/18639 0.0980392156862745 3.29252782193959 0.0175150456878681 0.136090354990692 GO:0034987 immunoglobulin receptor binding 3/555 19/18639 0.157894736842105 5.3027027027027 0.0178374748246242 0.137379849965088 GO:0005200 structural constituent of cytoskeleton 8/555 112/18639 0.0714285714285714 2.3988416988417 0.0187867144169707 0.14343248050522 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 23/555 484/18639 0.0475206611570248 1.59592360955997 0.0192007819575461 0.145330056540737 GO:0003714 transcription corepressor activity 12/555 204/18639 0.0588235294117647 1.97551669316375 0.0194596754270072 0.145955808090118 GO:0000175 3'-5'-RNA exonuclease activity 4/555 35/18639 0.114285714285714 3.83814671814672 0.0196159286499248 0.145955808090118 GO:0016004 phospholipase activator activity 3/555 20/18639 0.15 5.03756756756757 0.0205304962619338 0.148350384887254 GO:0016505 peptidase activator activity involved in apoptotic process 3/555 20/18639 0.15 5.03756756756757 0.0205304962619338 0.148350384887254 GO:0002020 protease binding 9/555 136/18639 0.0661764705882353 2.22245627980922 0.0206136070116686 0.148350384887254 GO:0016779 nucleotidyltransferase activity 9/555 136/18639 0.0661764705882353 2.22245627980922 0.0206136070116686 0.148350384887254 GO:0051219 phosphoprotein binding 7/555 93/18639 0.0752688172043011 2.52781168265039 0.0209891441946405 0.149824947991011 GO:0030695 GTPase regulator activity 23/555 489/18639 0.0470347648261759 1.57960537224341 0.0213453277972667 0.15099311153131 GO:0043539 protein serine/threonine kinase activator activity 6/555 73/18639 0.0821917808219178 2.76031099592743 0.0214967413911318 0.15099311153131 GO:0060589 nucleoside-triphosphatase regulator activity 23/555 490/18639 0.0469387755102041 1.57638168781026 0.021795764389074 0.151696936602856 GO:0051287 NAD binding 5/555 54/18639 0.0925925925925926 3.10960960960961 0.0219424953856068 0.151696936602856 GO:0070851 growth factor receptor binding 9/555 139/18639 0.0647482014388489 2.17448959751118 0.0233681827651755 0.156907398863691 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/555 21/18639 0.142857142857143 4.7976833976834 0.0234340307820997 0.156907398863691 GO:0008374 O-acyltransferase activity 5/555 55/18639 0.0909090909090909 3.05307125307125 0.0235655043333939 0.156907398863691 GO:0098632 cell-cell adhesion mediator activity 5/555 55/18639 0.0909090909090909 3.05307125307125 0.0235655043333939 0.156907398863691 GO:0019208 phosphatase regulator activity 8/555 117/18639 0.0683760683760684 2.2963270963271 0.0237340149637682 0.156907398863691 GO:0008094 ATP-dependent activity, acting on DNA 12/555 210/18639 0.0571428571428571 1.91907335907336 0.0237684328574839 0.156907398863691 GO:0098631 cell adhesion mediator activity 6/555 76/18639 0.0789473684210526 2.65135135135135 0.0256482701159369 0.167798146268673 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 4/555 38/18639 0.105263157894737 3.53513513513513 0.0258003983442721 0.167798146268673 GO:0061133 endopeptidase activator activity 3/555 22/18639 0.136363636363636 4.57960687960688 0.0265480527174866 0.170140075079951 GO:0140517 protein-RNA adaptor activity 3/555 22/18639 0.136363636363636 4.57960687960688 0.0265480527174866 0.170140075079951 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/555 23/18639 0.130434782608696 4.38049353701528 0.0298719119262229 0.188687328569955 GO:0070577 lysine-acetylated histone binding 3/555 23/18639 0.130434782608696 4.38049353701528 0.0298719119262229 0.188687328569955 GO:0061659 ubiquitin-like protein ligase activity 18/555 372/18639 0.0483870967741935 1.62502179598954 0.0304580584753054 0.191015538152272 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/555 60/18639 0.0833333333333333 2.79864864864865 0.0328322282472132 0.198973037983589 GO:0005540 hyaluronic acid binding 3/555 24/18639 0.125 4.19797297297297 0.0334043838223185 0.198973037983589 GO:0140033 acetylation-dependent protein binding 3/555 24/18639 0.125 4.19797297297297 0.0334043838223185 0.198973037983589 GO:0001618 virus receptor activity 6/555 81/18639 0.0740740740740741 2.48768768768769 0.0336917793910425 0.198973037983589 GO:0004955 prostaglandin receptor activity 2/555 10/18639 0.2 6.71675675675676 0.0339931158286313 0.198973037983589 GO:0005381 iron ion transmembrane transporter activity 2/555 10/18639 0.2 6.71675675675676 0.0339931158286313 0.198973037983589 GO:0008140 cAMP response element binding protein binding 2/555 10/18639 0.2 6.71675675675676 0.0339931158286313 0.198973037983589 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/555 10/18639 0.2 6.71675675675676 0.0339931158286313 0.198973037983589 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/555 10/18639 0.2 6.71675675675676 0.0339931158286313 0.198973037983589 GO:1905394 retromer complex binding 2/555 10/18639 0.2 6.71675675675676 0.0339931158286313 0.198973037983589 GO:0033218 amide binding 13/555 247/18639 0.0526315789473684 1.76756756756757 0.0342637934578703 0.199229209642451 GO:0140272 exogenous protein binding 6/555 82/18639 0.0731707317073171 2.45735003295979 0.0354752643019339 0.204916329323013 GO:0042974 nuclear retinoic acid receptor binding 3/555 25/18639 0.12 4.03005405405405 0.0371437166101979 0.211767423271128 GO:0120020 cholesterol transfer activity 3/555 25/18639 0.12 4.03005405405405 0.0371437166101979 0.211767423271128 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/555 43/18639 0.0930232558139535 3.12407291011942 0.0384470289003928 0.21220576118733 GO:0061134 peptidase regulator activity 12/555 226/18639 0.0530973451327434 1.783209758431 0.0386368314484686 0.21220576118733 GO:0035591 signaling adaptor activity 8/555 129/18639 0.062015503875969 2.08271527341295 0.0391831158382484 0.21220576118733 GO:0004527 exonuclease activity 6/555 84/18639 0.0714285714285714 2.3988416988417 0.0392215979591753 0.21220576118733 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/555 11/18639 0.181818181818182 6.10614250614251 0.0407418389277913 0.21220576118733 GO:0004954 prostanoid receptor activity 2/555 11/18639 0.181818181818182 6.10614250614251 0.0407418389277913 0.21220576118733 GO:0010854 adenylate cyclase regulator activity 2/555 11/18639 0.181818181818182 6.10614250614251 0.0407418389277913 0.21220576118733 GO:0015173 aromatic amino acid transmembrane transporter activity 2/555 11/18639 0.181818181818182 6.10614250614251 0.0407418389277913 0.21220576118733 GO:0019215 intermediate filament binding 2/555 11/18639 0.181818181818182 6.10614250614251 0.0407418389277913 0.21220576118733 GO:0032794 GTPase activating protein binding 2/555 11/18639 0.181818181818182 6.10614250614251 0.0407418389277913 0.21220576118733 GO:0034511 U3 snoRNA binding 2/555 11/18639 0.181818181818182 6.10614250614251 0.0407418389277913 0.21220576118733 GO:0043522 leucine zipper domain binding 2/555 11/18639 0.181818181818182 6.10614250614251 0.0407418389277913 0.21220576118733 GO:0048185 activin binding 2/555 11/18639 0.181818181818182 6.10614250614251 0.0407418389277913 0.21220576118733 GO:0005160 transforming growth factor beta receptor binding 3/555 26/18639 0.115384615384615 3.87505197505198 0.0410876758563168 0.21220576118733 GO:0008143 poly(A) binding 3/555 26/18639 0.115384615384615 3.87505197505198 0.0410876758563168 0.21220576118733 GO:0019865 immunoglobulin binding 3/555 26/18639 0.115384615384615 3.87505197505198 0.0410876758563168 0.21220576118733 GO:0016755 aminoacyltransferase activity 22/555 496/18639 0.0443548387096774 1.48960331299041 0.0417925356938696 0.21458389672057 GO:0001671 ATPase activator activity 3/555 27/18639 0.111111111111111 3.73153153153153 0.045233586524819 0.229566988258908 GO:0035255 ionotropic glutamate receptor binding 3/555 27/18639 0.111111111111111 3.73153153153153 0.045233586524819 0.229566988258908 GO:0030291 protein serine/threonine kinase inhibitor activity 4/555 46/18639 0.0869565217391304 2.92032902467685 0.0474634821515263 0.235171828236253 GO:0004859 phospholipase inhibitor activity 2/555 12/18639 0.166666666666667 5.5972972972973 0.0479450538203751 0.235171828236253 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/555 12/18639 0.166666666666667 5.5972972972973 0.0479450538203751 0.235171828236253 GO:0097677 STAT family protein binding 2/555 12/18639 0.166666666666667 5.5972972972973 0.0479450538203751 0.235171828236253 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/555 12/18639 0.166666666666667 5.5972972972973 0.0479450538203751 0.235171828236253 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/555 12/18639 0.166666666666667 5.5972972972973 0.0479450538203751 0.235171828236253 GO:0019789 SUMO transferase activity 3/555 28/18639 0.107142857142857 3.59826254826255 0.0495783725986963 0.239540439295299 GO:0097718 disordered domain specific binding 3/555 28/18639 0.107142857142857 3.59826254826255 0.0495783725986963 0.239540439295299 GO:0003727 single-stranded RNA binding 6/555 89/18639 0.0674157303370786 2.26407531126632 0.0496541685099594 0.239540439295299 GO:0015078 proton transmembrane transporter activity 10/555 185/18639 0.0540540540540541 1.81533966398831 0.050600382523224 0.241259072366697 GO:0019787 ubiquitin-like protein transferase activity 21/555 479/18639 0.0438413361169102 1.4723579529425 0.0507966678070001 0.241259072366697 GO:0051020 GTPase binding 15/555 315/18639 0.0476190476190476 1.5992277992278 0.0508347703733928 0.241259072366697 GO:0008234 cysteine-type peptidase activity 10/555 187/18639 0.053475935828877 1.7959242665125 0.0536777321681132 0.252745350454932 GO:0038187 pattern recognition receptor activity 4/555 48/18639 0.0833333333333333 2.79864864864865 0.0540694271364979 0.252745350454932 GO:0004629 phospholipase C activity 3/555 29/18639 0.103448275862069 3.47418452935694 0.0541185944026505 0.252745350454932 GO:0019855 calcium channel inhibitor activity 2/555 13/18639 0.153846153846154 5.16673596673597 0.0555698158794716 0.25679104390619 GO:0035325 Toll-like receptor binding 2/555 13/18639 0.153846153846154 5.16673596673597 0.0555698158794716 0.25679104390619 GO:0017124 SH3 domain binding 7/555 115/18639 0.0608695652173913 2.0442303172738 0.0562012621812968 0.25834925756638 GO:0016763 pentosyltransferase activity 4/555 49/18639 0.0816326530612245 2.7415333701048 0.0575494928353454 0.261994801974098 GO:0019902 phosphatase binding 10/555 190/18639 0.0526315789473684 1.76756756756757 0.058521739178475 0.261994801974098 GO:0001968 fibronectin binding 3/555 30/18639 0.1 3.35837837837838 0.0588504837388065 0.261994801974098 GO:0035925 mRNA 3'-UTR AU-rich region binding 3/555 30/18639 0.1 3.35837837837838 0.0588504837388065 0.261994801974098 GO:0048019 receptor antagonist activity 3/555 30/18639 0.1 3.35837837837838 0.0588504837388065 0.261994801974098 GO:0070566 adenylyltransferase activity 3/555 30/18639 0.1 3.35837837837838 0.0588504837388065 0.261994801974098 GO:0005539 glycosaminoglycan binding 12/555 242/18639 0.0495867768595041 1.66531159258432 0.0590831102401725 0.261994801974098 GO:0015399 primary active transmembrane transporter activity 9/555 166/18639 0.0542168674698795 1.82080755454249 0.0606731751479752 0.267693707436795 GO:0001664 G protein-coupled receptor binding 14/555 297/18639 0.0471380471380471 1.58307398307398 0.0617713450664372 0.271176204841659 GO:0042379 chemokine receptor binding 5/555 72/18639 0.0694444444444444 2.33220720720721 0.0632987517162422 0.275421921783914 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/555 14/18639 0.142857142857143 4.7976833976834 0.0635847332934031 0.275421921783914 GO:0005164 tumor necrosis factor receptor binding 3/555 31/18639 0.0967741935483871 3.25004359197908 0.0637699769415754 0.275421921783914 GO:0061630 ubiquitin protein ligase activity 16/555 353/18639 0.0453257790368272 1.52221116300436 0.0639932483415927 0.275421921783914 GO:0005080 protein kinase C binding 4/555 52/18639 0.0769230769230769 2.58336798336798 0.068688429758035 0.290722456476028 GO:0030159 signaling receptor complex adaptor activity 4/555 52/18639 0.0769230769230769 2.58336798336798 0.068688429758035 0.290722456476028 GO:0070717 poly-purine tract binding 3/555 32/18639 0.09375 3.14847972972973 0.0688727459533186 0.290722456476028 GO:0120015 sterol transfer activity 3/555 32/18639 0.09375 3.14847972972973 0.0688727459533186 0.290722456476028 GO:0031386 protein tag activity 2/555 15/18639 0.133333333333333 4.47783783783784 0.0719599040732233 0.29662345434878 GO:0042809 nuclear vitamin D receptor binding 2/555 15/18639 0.133333333333333 4.47783783783784 0.0719599040732233 0.29662345434878 GO:0141047 molecular tag activity 2/555 15/18639 0.133333333333333 4.47783783783784 0.0719599040732233 0.29662345434878 GO:0141050 histone H3K deacetylase activity 2/555 15/18639 0.133333333333333 4.47783783783784 0.0719599040732233 0.29662345434878 GO:0141051 histone H4K deacetylase activity 2/555 15/18639 0.133333333333333 4.47783783783784 0.0719599040732233 0.29662345434878 GO:0140296 general transcription initiation factor binding 4/555 53/18639 0.0754716981132075 2.53462519122896 0.0726308419854308 0.297990090014992 GO:0004857 enzyme inhibitor activity 18/555 416/18639 0.0432692307692308 1.45314449064449 0.0736135329371586 0.30003415557977 GO:0071889 14-3-3 protein binding 3/555 33/18639 0.0909090909090909 3.05307125307125 0.074154227518007 0.30003415557977 GO:0140416 transcription regulator inhibitor activity 3/555 33/18639 0.0909090909090909 3.05307125307125 0.074154227518007 0.30003415557977 GO:0016887 ATP hydrolysis activity 18/555 417/18639 0.0431654676258993 1.44965973167412 0.0749177796809411 0.301733075962689 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 4/555 54/18639 0.0740740740740741 2.48768768768769 0.0766859097134167 0.306046494219909 GO:0017069 snRNA binding 4/555 54/18639 0.0740740740740741 2.48768768768769 0.0766859097134167 0.306046494219909 GO:0140097 catalytic activity, acting on DNA 15/555 336/18639 0.0446428571428571 1.49927606177606 0.0786877496244713 0.312614679503556 GO:0004842 ubiquitin-protein transferase activity 19/555 449/18639 0.0423162583518931 1.42114007102871 0.0798498625435361 0.314779995832858 GO:0022858 alanine transmembrane transporter activity 2/555 16/18639 0.125 4.19797297297297 0.0806668554241378 0.314779995832858 GO:0030275 LRR domain binding 2/555 16/18639 0.125 4.19797297297297 0.0806668554241378 0.314779995832858 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/555 16/18639 0.125 4.19797297297297 0.0806668554241378 0.314779995832858 GO:0031267 small GTPase binding 13/555 283/18639 0.0459363957597173 1.54271798300067 0.0818024437144397 0.317798874253443 GO:0005154 epidermal growth factor receptor binding 3/555 35/18639 0.0857142857142857 2.87861003861004 0.0852340620172754 0.328733340507752 GO:0042826 histone deacetylase binding 7/555 127/18639 0.0551181102362205 1.85107469674399 0.0853658332981406 0.328733340507752 GO:0033293 monocarboxylic acid binding 5/555 79/18639 0.0632911392405063 2.12555593568252 0.0865183766064403 0.33171674524216 GO:0031490 chromatin DNA binding 7/555 128/18639 0.0546875 1.83661317567568 0.0881239352641388 0.335788335673957 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/555 17/18639 0.117647058823529 3.9510333863275 0.0896784853963095 0.335788335673957 GO:0008429 phosphatidylethanolamine binding 2/555 17/18639 0.117647058823529 3.9510333863275 0.0896784853963095 0.335788335673957 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/555 17/18639 0.117647058823529 3.9510333863275 0.0896784853963095 0.335788335673957 GO:0046965 nuclear retinoid X receptor binding 2/555 17/18639 0.117647058823529 3.9510333863275 0.0896784853963095 0.335788335673957 GO:0005484 SNAP receptor activity 3/555 36/18639 0.0833333333333333 2.79864864864865 0.0910223506724395 0.335788335673957 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 3/555 36/18639 0.0833333333333333 2.79864864864865 0.0910223506724395 0.335788335673957 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 3/555 36/18639 0.0833333333333333 2.79864864864865 0.0910223506724395 0.335788335673957 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 3/555 36/18639 0.0833333333333333 2.79864864864865 0.0910223506724395 0.335788335673957 GO:0004386 helicase activity 8/555 155/18639 0.0516129032258065 1.73335658238884 0.092348742819449 0.339256051027097 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7/555 130/18639 0.0538461538461538 1.80835758835759 0.0937898840704659 0.342466464293956 GO:0008408 3'-5' exonuclease activity 4/555 58/18639 0.0689655172413793 2.3161230195713 0.0940027538665641 0.342466464293956 GO:0004518 nuclease activity 10/555 209/18639 0.0478468899521531 1.60687960687961 0.0957337088789638 0.347331390065001 GO:0019213 deacetylase activity 3/555 37/18639 0.0810810810810811 2.72300949598247 0.0969692699652122 0.350366333454553 GO:0001786 phosphatidylserine binding 4/555 59/18639 0.0677966101694915 2.27686669720568 0.0985976950617338 0.350382209322435 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/555 18/18639 0.111111111111111 3.73153153153153 0.0989690067334441 0.350382209322435 GO:0004706 JUN kinase kinase kinase activity 2/555 18/18639 0.111111111111111 3.73153153153153 0.0989690067334441 0.350382209322435 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/555 18/18639 0.111111111111111 3.73153153153153 0.0989690067334441 0.350382209322435 GO:1901611 phosphatidylglycerol binding 2/555 18/18639 0.111111111111111 3.73153153153153 0.0989690067334441 0.350382209322435 GO:0008135 translation factor activity, RNA binding 5/555 83/18639 0.0602409638554217 2.02311950504722 0.101529815503238 0.358004730971257 GO:0043531 ADP binding 3/555 38/18639 0.0789473684210526 2.65135135135135 0.103069458961293 0.36197993987206 GO:0004860 protein kinase inhibitor activity 5/555 84/18639 0.0595238095238095 1.99903474903475 0.105473373575647 0.366867386420486 GO:0180051 translation factor activity 5/555 84/18639 0.0595238095238095 1.99903474903475 0.105473373575647 0.366867386420486 GO:0051087 protein-folding chaperone binding 7/555 134/18639 0.0522388059701493 1.75437676482453 0.105714634127999 0.366867386420486 GO:0031406 carboxylic acid binding 9/555 187/18639 0.0481283422459893 1.61633183986125 0.107212711787379 0.36928371284434 GO:0008301 DNA binding, bending 2/555 19/18639 0.105263157894737 3.53513513513513 0.108513892840364 0.36928371284434 GO:0043395 heparan sulfate proteoglycan binding 2/555 19/18639 0.105263157894737 3.53513513513513 0.108513892840364 0.36928371284434 GO:0097001 ceramide binding 2/555 19/18639 0.105263157894737 3.53513513513513 0.108513892840364 0.36928371284434 GO:0140036 ubiquitin-modified protein reader activity 2/555 19/18639 0.105263157894737 3.53513513513513 0.108513892840364 0.36928371284434 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/555 39/18639 0.0769230769230769 2.58336798336798 0.109317462093188 0.370581975744475 GO:0004222 metalloendopeptidase activity 6/555 110/18639 0.0545454545454545 1.83184275184275 0.11045359211932 0.372993284156781 GO:0043177 organic acid binding 9/555 189/18639 0.0476190476190476 1.5992277992278 0.112472181346689 0.378354694338671 GO:0000339 RNA cap binding 2/555 20/18639 0.1 3.35837837837838 0.118289825793523 0.391918743572503 GO:0001972 retinoic acid binding 2/555 20/18639 0.1 3.35837837837838 0.118289825793523 0.391918743572503 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/555 20/18639 0.1 3.35837837837838 0.118289825793523 0.391918743572503 GO:0010851 cyclase regulator activity 2/555 20/18639 0.1 3.35837837837838 0.118289825793523 0.391918743572503 GO:0042393 histone binding 11/555 247/18639 0.0445344129554656 1.4956340956341 0.120872474479235 0.396022465360052 GO:0004197 cysteine-type endopeptidase activity 5/555 88/18639 0.0568181818181818 1.90816953316953 0.121981685762113 0.396022465360052 GO:0001530 lipopolysaccharide binding 3/555 41/18639 0.0731707317073171 2.45735003295979 0.122234724501793 0.396022465360052 GO:0008137 NADH dehydrogenase (ubiquinone) activity 3/555 41/18639 0.0731707317073171 2.45735003295979 0.122234724501793 0.396022465360052 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/555 41/18639 0.0731707317073171 2.45735003295979 0.122234724501793 0.396022465360052 GO:0042169 SH2 domain binding 3/555 41/18639 0.0731707317073171 2.45735003295979 0.122234724501793 0.396022465360052 GO:0005123 death receptor binding 2/555 21/18639 0.0952380952380952 3.1984555984556 0.128274646321041 0.408548167345329 GO:0035613 RNA stem-loop binding 2/555 21/18639 0.0952380952380952 3.1984555984556 0.128274646321041 0.408548167345329 GO:0070182 DNA polymerase binding 2/555 21/18639 0.0952380952380952 3.1984555984556 0.128274646321041 0.408548167345329 GO:0072542 protein phosphatase activator activity 2/555 21/18639 0.0952380952380952 3.1984555984556 0.128274646321041 0.408548167345329 GO:0016859 cis-trans isomerase activity 3/555 42/18639 0.0714285714285714 2.3988416988417 0.128892758946077 0.408548167345329 GO:0042056 chemoattractant activity 3/555 42/18639 0.0714285714285714 2.3988416988417 0.128892758946077 0.408548167345329 GO:0019210 kinase inhibitor activity 5/555 90/18639 0.0555555555555556 1.86576576576577 0.130661047901885 0.412663309560629 GO:0020037 heme binding 7/555 142/18639 0.0492957746478873 1.65553863722878 0.131866984916661 0.414979257192932 GO:0009055 electron transfer activity 6/555 116/18639 0.0517241379310345 1.73709226467847 0.13268551476024 0.416063864141039 GO:0072341 modified amino acid binding 5/555 91/18639 0.0549450549450549 1.84526284526285 0.135102918289858 0.4204509705417 GO:0008200 ion channel inhibitor activity 3/555 43/18639 0.0697674418604651 2.34305468258957 0.135676188699504 0.4204509705417 GO:1990782 protein tyrosine kinase binding 6/555 117/18639 0.0512820512820513 1.72224532224532 0.136584342998349 0.4204509705417 GO:0004407 histone deacetylase activity 2/555 22/18639 0.0909090909090909 3.05307125307125 0.138447305681397 0.4204509705417 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/555 22/18639 0.0909090909090909 3.05307125307125 0.138447305681397 0.4204509705417 GO:0033558 protein lysine deacetylase activity 2/555 22/18639 0.0909090909090909 3.05307125307125 0.138447305681397 0.4204509705417 GO:0034062 5'-3' RNA polymerase activity 2/555 22/18639 0.0909090909090909 3.05307125307125 0.138447305681397 0.4204509705417 GO:0097747 RNA polymerase activity 2/555 22/18639 0.0909090909090909 3.05307125307125 0.138447305681397 0.4204509705417 GO:0140035 ubiquitin-like protein reader activity 2/555 22/18639 0.0909090909090909 3.05307125307125 0.138447305681397 0.4204509705417 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/555 67/18639 0.0597014925373134 2.00500201694232 0.138873327399878 0.4204509705417 GO:0052689 carboxylic ester hydrolase activity 5/555 92/18639 0.0543478260869565 1.82520564042303 0.139611242931911 0.421232547402811 GO:0022853 active monoatomic ion transmembrane transporter activity 6/555 118/18639 0.0508474576271186 1.70765002290426 0.140536504072752 0.42149716498942 GO:0008201 heparin binding 8/555 172/18639 0.0465116279069767 1.56203645505971 0.142271538051111 0.42149716498942 GO:0001046 core promoter sequence-specific DNA binding 3/555 44/18639 0.0681818181818182 2.28980343980344 0.142579337131956 0.42149716498942 GO:0003954 NADH dehydrogenase activity 3/555 44/18639 0.0681818181818182 2.28980343980344 0.142579337131956 0.42149716498942 GO:0016248 channel inhibitor activity 3/555 44/18639 0.0681818181818182 2.28980343980344 0.142579337131956 0.42149716498942 GO:0030547 signaling receptor inhibitor activity 3/555 44/18639 0.0681818181818182 2.28980343980344 0.142579337131956 0.42149716498942 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 4/555 68/18639 0.0588235294117647 1.97551669316375 0.144313702109258 0.423770670407787 GO:0030145 manganese ion binding 4/555 68/18639 0.0588235294117647 1.97551669316375 0.144313702109258 0.423770670407787 GO:0140030 modification-dependent protein binding 8/555 173/18639 0.046242774566474 1.55300734260272 0.145561546053719 0.426010124783886 GO:0000295 adenine nucleotide transmembrane transporter activity 2/555 23/18639 0.0869565217391304 2.92032902467685 0.148787819372366 0.427836318589441 GO:0005158 insulin receptor binding 2/555 23/18639 0.0869565217391304 2.92032902467685 0.148787819372366 0.427836318589441 GO:0043274 phospholipase binding 2/555 23/18639 0.0869565217391304 2.92032902467685 0.148787819372366 0.427836318589441 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/555 23/18639 0.0869565217391304 2.92032902467685 0.148787819372366 0.427836318589441 GO:0008009 chemokine activity 3/555 45/18639 0.0666666666666667 2.23891891891892 0.149596525976035 0.427836318589441 GO:0046915 transition metal ion transmembrane transporter activity 3/555 45/18639 0.0666666666666667 2.23891891891892 0.149596525976035 0.427836318589441 GO:0141110 transporter inhibitor activity 3/555 45/18639 0.0666666666666667 2.23891891891892 0.149596525976035 0.427836318589441 GO:0004674 protein serine/threonine kinase activity 17/555 433/18639 0.0392609699769053 1.31853192684601 0.151021488439982 0.430509307955534 GO:0004175 endopeptidase activity 16/555 405/18639 0.0395061728395062 1.32676676676677 0.154229695526425 0.438231950395473 GO:0004896 cytokine receptor activity 5/555 96/18639 0.0520833333333333 1.74915540540541 0.158282613211138 0.442548738754674 GO:0035035 histone acetyltransferase binding 2/555 24/18639 0.0833333333333333 2.79864864864865 0.159277222604188 0.442548738754674 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/555 24/18639 0.0833333333333333 2.79864864864865 0.159277222604188 0.442548738754674 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/555 24/18639 0.0833333333333333 2.79864864864865 0.159277222604188 0.442548738754674 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/555 24/18639 0.0833333333333333 2.79864864864865 0.159277222604188 0.442548738754674 GO:0050431 transforming growth factor beta binding 2/555 24/18639 0.0833333333333333 2.79864864864865 0.159277222604188 0.442548738754674 GO:0070300 phosphatidic acid binding 2/555 24/18639 0.0833333333333333 2.79864864864865 0.159277222604188 0.442548738754674 GO:0140359 ABC-type transporter activity 3/555 47/18639 0.0638297872340425 2.14364577343301 0.16395037382005 0.454095988056796 GO:0042626 ATPase-coupled transmembrane transporter activity 5/555 98/18639 0.0510204081632653 1.7134583563155 0.167981746931981 0.460401324449064 GO:0046906 tetrapyrrole binding 7/555 152/18639 0.0460526315789474 1.54662162162162 0.168588999708811 0.460401324449064 GO:0004709 MAP kinase kinase kinase activity 2/555 25/18639 0.08 2.6867027027027 0.169897527473231 0.460401324449064 GO:0005537 D-mannose binding 2/555 25/18639 0.08 2.6867027027027 0.169897527473231 0.460401324449064 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/555 25/18639 0.08 2.6867027027027 0.169897527473231 0.460401324449064 GO:0019211 phosphatase activator activity 2/555 25/18639 0.08 2.6867027027027 0.169897527473231 0.460401324449064 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/555 25/18639 0.08 2.6867027027027 0.169897527473231 0.460401324449064 GO:0004521 RNA endonuclease activity 4/555 73/18639 0.0547945205479452 1.84020733061829 0.172698264316376 0.466551003291626 GO:0043130 ubiquitin binding 5/555 100/18639 0.05 1.67918918918919 0.177907753567135 0.470607170914345 GO:0048029 monosaccharide binding 4/555 74/18639 0.0540540540540541 1.81533966398831 0.178593710444311 0.470607170914345 GO:0035254 glutamate receptor binding 3/555 49/18639 0.0612244897959184 2.0561500275786 0.178692701402378 0.470607170914345 GO:0060590 ATPase regulator activity 3/555 49/18639 0.0612244897959184 2.0561500275786 0.178692701402378 0.470607170914345 GO:0004435 phosphatidylinositol phospholipase C activity 2/555 26/18639 0.0769230769230769 2.58336798336798 0.18063168177464 0.470607170914345 GO:0004529 DNA exonuclease activity 2/555 26/18639 0.0769230769230769 2.58336798336798 0.18063168177464 0.470607170914345 GO:0015216 purine nucleotide transmembrane transporter activity 2/555 26/18639 0.0769230769230769 2.58336798336798 0.18063168177464 0.470607170914345 GO:0030247 polysaccharide binding 2/555 26/18639 0.0769230769230769 2.58336798336798 0.18063168177464 0.470607170914345 GO:0043548 phosphatidylinositol 3-kinase binding 2/555 26/18639 0.0769230769230769 2.58336798336798 0.18063168177464 0.470607170914345 GO:0051139 metal cation:proton antiporter activity 2/555 26/18639 0.0769230769230769 2.58336798336798 0.18063168177464 0.470607170914345 GO:0070412 R-SMAD binding 2/555 26/18639 0.0769230769230769 2.58336798336798 0.18063168177464 0.470607170914345 GO:0120014 phospholipid transfer activity 2/555 26/18639 0.0769230769230769 2.58336798336798 0.18063168177464 0.470607170914345 GO:0061135 endopeptidase regulator activity 8/555 184/18639 0.0434782608695652 1.46016451233843 0.184110473853749 0.478251467584591 GO:0005096 GTPase activator activity 11/555 271/18639 0.040590405904059 1.36317941557794 0.186629118618471 0.483363911938104 GO:0008320 protein transmembrane transporter activity 2/555 27/18639 0.0740740740740741 2.48768768768769 0.191463529394626 0.491535025755795 GO:0015252 proton channel activity 2/555 27/18639 0.0740740740740741 2.48768768768769 0.191463529394626 0.491535025755795 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/555 27/18639 0.0740740740740741 2.48768768768769 0.191463529394626 0.491535025755795 GO:0005010 insulin-like growth factor receptor activity 3/555 51/18639 0.0588235294117647 1.97551669316375 0.193779120514013 0.496029352219543 GO:0005179 hormone activity 6/555 132/18639 0.0454545454545455 1.52653562653563 0.200982904286189 0.510596793142592 GO:0046625 sphingolipid binding 2/555 28/18639 0.0714285714285714 2.3988416988417 0.202377772225082 0.510596793142592 GO:0046875 ephrin receptor binding 2/555 28/18639 0.0714285714285714 2.3988416988417 0.202377772225082 0.510596793142592 GO:0051019 mitogen-activated protein kinase binding 2/555 28/18639 0.0714285714285714 2.3988416988417 0.202377772225082 0.510596793142592 GO:0051959 dynein light intermediate chain binding 2/555 28/18639 0.0714285714285714 2.3988416988417 0.202377772225082 0.510596793142592 GO:0000149 SNARE binding 5/555 106/18639 0.0471698113207547 1.5841407445181 0.20892529467331 0.523424030969593 GO:0038064 collagen receptor activity 3/555 53/18639 0.0566037735849057 1.90096889342172 0.209166147768667 0.523424030969593 GO:0008083 growth factor activity 7/555 162/18639 0.0432098765432099 1.45115115115115 0.209250381401284 0.523424030969593 GO:0003785 actin monomer binding 2/555 29/18639 0.0689655172413793 2.3161230195713 0.213359933545262 0.53067994802476 GO:0051861 glycolipid binding 2/555 29/18639 0.0689655172413793 2.3161230195713 0.213359933545262 0.53067994802476 GO:0030246 carbohydrate binding 11/555 280/18639 0.0392857142857143 1.31936293436293 0.214848022627793 0.532426281482113 GO:0048306 calcium-dependent protein binding 4/555 80/18639 0.05 1.67918918918919 0.215274863241629 0.532426281482113 GO:0004843 cysteine-type deubiquitinase activity 5/555 108/18639 0.0462962962962963 1.5548048048048 0.219635810687922 0.540545303623816 GO:0044325 transmembrane transporter binding 6/555 136/18639 0.0441176470588235 1.48163751987281 0.219788921860709 0.540545303623816 GO:0015215 nucleotide transmembrane transporter activity 2/555 30/18639 0.0666666666666667 2.23891891891892 0.224396322817152 0.547277698426276 GO:0031210 phosphatidylcholine binding 2/555 30/18639 0.0666666666666667 2.23891891891892 0.224396322817152 0.547277698426276 GO:0031624 ubiquitin conjugating enzyme binding 2/555 30/18639 0.0666666666666667 2.23891891891892 0.224396322817152 0.547277698426276 GO:0004620 phospholipase activity 5/555 109/18639 0.0458715596330275 1.54054054054054 0.225053492286481 0.547360017250775 GO:0005201 extracellular matrix structural constituent 7/555 168/18639 0.0416666666666667 1.39932432432432 0.235247011742708 0.568473554083317 GO:0004713 protein tyrosine kinase activity 6/555 140/18639 0.0428571428571429 1.43930501930502 0.239155291060413 0.568473554083317 GO:0022884 macromolecule transmembrane transporter activity 2/555 32/18639 0.0625 2.09898648648649 0.246580752235703 0.568473554083317 GO:0030515 snoRNA binding 2/555 32/18639 0.0625 2.09898648648649 0.246580752235703 0.568473554083317 GO:0043425 bHLH transcription factor binding 2/555 32/18639 0.0625 2.09898648648649 0.246580752235703 0.568473554083317 GO:0005085 guanyl-nucleotide exchange factor activity 9/555 230/18639 0.0391304347826087 1.31414806110458 0.248197412507158 0.568473554083317 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 3/555 58/18639 0.0517241379310345 1.73709226467847 0.248674134930782 0.568473554083317 GO:0004879 nuclear receptor activity 3/555 59/18639 0.0508474576271186 1.70765002290426 0.256713944209482 0.568473554083317 GO:0015459 potassium channel regulator activity 3/555 59/18639 0.0508474576271186 1.70765002290426 0.256713944209482 0.568473554083317 GO:0070063 RNA polymerase binding 3/555 59/18639 0.0508474576271186 1.70765002290426 0.256713944209482 0.568473554083317 GO:0019239 deaminase activity 2/555 33/18639 0.0606060606060606 2.03538083538084 0.257705044152974 0.568473554083317 GO:0030296 protein tyrosine kinase activator activity 2/555 33/18639 0.0606060606060606 2.03538083538084 0.257705044152974 0.568473554083317 GO:0035401 histone H3Y41 kinase activity 5/555 115/18639 0.0434782608695652 1.46016451233843 0.258331243529 0.568473554083317 GO:0101005 deubiquitinase activity 5/555 115/18639 0.0434782608695652 1.46016451233843 0.258331243529 0.568473554083317 GO:0140801 histone H2AXY142 kinase activity 5/555 115/18639 0.0434782608695652 1.46016451233843 0.258331243529 0.568473554083317 GO:0008081 phosphoric diester hydrolase activity 4/555 87/18639 0.0459770114942529 1.54408201304753 0.260340431487312 0.568473554083317 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0005031 tumor necrosis factor receptor activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0005131 growth hormone receptor binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0005522 profilin binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0005528 FK506 binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0016427 tRNA (cytidine) methyltransferase activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0030957 Tat protein binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0031434 mitogen-activated protein kinase kinase binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0042975 peroxisome proliferator activated receptor binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0043208 glycosphingolipid binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0043422 protein kinase B binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0050815 phosphoserine residue binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0070513 death domain binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0098505 G-rich strand telomeric DNA binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0099122 RNA polymerase II C-terminal domain binding 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0141109 transporter activator activity 1/555 10/18639 0.1 3.35837837837838 0.260928066395873 0.568473554083317 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/555 60/18639 0.05 1.67918918918919 0.264788613462316 0.571096995556952 GO:0098531 ligand-modulated transcription factor activity 3/555 60/18639 0.05 1.67918918918919 0.264788613462316 0.571096995556952 GO:0016651 oxidoreductase activity, acting on NAD(P)H 4/555 88/18639 0.0454545454545455 1.52653562653563 0.266928943188512 0.571096995556952 GO:0015035 protein-disulfide reductase activity 2/555 34/18639 0.0588235294117647 1.97551669316375 0.268836006250921 0.571096995556952 GO:0030332 cyclin binding 2/555 34/18639 0.0588235294117647 1.97551669316375 0.268836006250921 0.571096995556952 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/555 34/18639 0.0588235294117647 1.97551669316375 0.268836006250921 0.571096995556952 GO:0019905 syntaxin binding 3/555 61/18639 0.0491803278688525 1.65166149756314 0.272893540750681 0.571096995556952 GO:0043021 ribonucleoprotein complex binding 7/555 177/18639 0.0395480225988701 1.32817224003665 0.276050585228658 0.571096995556952 GO:0005319 lipid transporter activity 7/555 178/18639 0.0393258426966292 1.32071059823869 0.280696361306698 0.571096995556952 GO:0106310 protein serine kinase activity 13/555 361/18639 0.03601108033241 1.20938833570413 0.280803072745789 0.571096995556952 GO:0015179 L-amino acid transmembrane transporter activity 3/555 62/18639 0.0483870967741935 1.62502179598954 0.281024229844674 0.571096995556952 GO:0000099 sulfur amino acid transmembrane transporter activity 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0001851 complement component C3b binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0002162 dystroglycan binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0003953 NAD+ nucleosidase activity 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0008432 JUN kinase binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0008526 phosphatidylinositol transfer activity 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0015217 ADP transmembrane transporter activity 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0019864 IgG binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0031731 CCR6 chemokine receptor binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0032050 clathrin heavy chain binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0048407 platelet-derived growth factor binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0050998 nitric-oxide synthase binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0140031 phosphorylation-dependent protein binding 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0180030 inositol phosphate kinase activity 1/555 11/18639 0.0909090909090909 3.05307125307125 0.282946689142681 0.571096995556952 GO:0032182 ubiquitin-like protein binding 5/555 120/18639 0.0416666666666667 1.39932432432432 0.286894499387159 0.577737088215426 GO:0000993 RNA polymerase II complex binding 2/555 36/18639 0.0555555555555556 1.86576576576577 0.291077575995131 0.579380495538779 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/555 36/18639 0.0555555555555556 1.86576576576577 0.291077575995131 0.579380495538779 GO:0022829 wide pore channel activity 2/555 37/18639 0.0540540540540541 1.81533966398831 0.302169479196841 0.579380495538779 GO:0030280 structural constituent of skin epidermis 2/555 37/18639 0.0540540540540541 1.81533966398831 0.302169479196841 0.579380495538779 GO:0000340 RNA 7-methylguanosine cap binding 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0004000 adenosine deaminase activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0004875 complement receptor activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0005078 MAP-kinase scaffold activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0005095 GTPase inhibitor activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0005165 neurotrophin receptor binding 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0005527 macrolide binding 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0008179 adenylate cyclase binding 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0010853 cyclase activator activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0016840 carbon-nitrogen lyase activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0017166 vinculin binding 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0031543 peptidyl-proline dioxygenase activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0035497 cAMP response element binding 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0043047 single-stranded telomeric DNA binding 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/555 12/18639 0.0833333333333333 2.79864864864865 0.304310474171982 0.579380495538779 GO:0019843 rRNA binding 3/555 65/18639 0.0461538461538462 1.55002079002079 0.305527527829675 0.579380495538779 GO:0160215 deacylase activity 3/555 65/18639 0.0461538461538462 1.55002079002079 0.305527527829675 0.579380495538779 GO:0008237 metallopeptidase activity 7/555 184/18639 0.0380434782608696 1.27764394829612 0.308947866777676 0.584603937566379 GO:0005501 retinoid binding 2/555 38/18639 0.0526315789473684 1.76756756756757 0.313230591432149 0.58861309711733 GO:0019840 isoprenoid binding 2/555 38/18639 0.0526315789473684 1.76756756756757 0.313230591432149 0.58861309711733 GO:0042162 telomeric DNA binding 2/555 38/18639 0.0526315789473684 1.76756756756757 0.313230591432149 0.58861309711733 GO:0004867 serine-type endopeptidase inhibitor activity 4/555 95/18639 0.0421052631578947 1.41405405405405 0.313748211219716 0.58861309711733 GO:0050840 extracellular matrix binding 3/555 67/18639 0.0447761194029851 1.50375151270674 0.321914340266896 0.594550252405699 GO:0000217 DNA secondary structure binding 2/555 39/18639 0.0512820512820513 1.72224532224532 0.324252922747768 0.594550252405699 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/555 39/18639 0.0512820512820513 1.72224532224532 0.324252922747768 0.594550252405699 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/555 13/18639 0.0769230769230769 2.58336798336798 0.325038862363025 0.594550252405699 GO:0004465 lipoprotein lipase activity 1/555 13/18639 0.0769230769230769 2.58336798336798 0.325038862363025 0.594550252405699 GO:0005035 death receptor activity 1/555 13/18639 0.0769230769230769 2.58336798336798 0.325038862363025 0.594550252405699 GO:0005542 folic acid binding 1/555 13/18639 0.0769230769230769 2.58336798336798 0.325038862363025 0.594550252405699 GO:0008035 high-density lipoprotein particle binding 1/555 13/18639 0.0769230769230769 2.58336798336798 0.325038862363025 0.594550252405699 GO:0031432 titin binding 1/555 13/18639 0.0769230769230769 2.58336798336798 0.325038862363025 0.594550252405699 GO:0043560 insulin receptor substrate binding 1/555 13/18639 0.0769230769230769 2.58336798336798 0.325038862363025 0.594550252405699 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/555 13/18639 0.0769230769230769 2.58336798336798 0.325038862363025 0.594550252405699 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/555 13/18639 0.0769230769230769 2.58336798336798 0.325038862363025 0.594550252405699 GO:0004519 endonuclease activity 5/555 127/18639 0.0393700787401575 1.32219621195999 0.327749846910448 0.597021505367995 GO:0019783 ubiquitin-like protein peptidase activity 5/555 127/18639 0.0393700787401575 1.32219621195999 0.327749846910448 0.597021505367995 GO:0005548 phospholipid transporter activity 3/555 68/18639 0.0441176470588235 1.48163751987281 0.330111292797247 0.598270180264024 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 5/555 128/18639 0.0390625 1.31186655405405 0.333641879746068 0.598270180264024 GO:0015036 disulfide oxidoreductase activity 2/555 40/18639 0.05 1.67918918918919 0.335228984599588 0.598270180264024 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/555 40/18639 0.05 1.67918918918919 0.335228984599588 0.598270180264024 GO:0050997 quaternary ammonium group binding 2/555 40/18639 0.05 1.67918918918919 0.335228984599588 0.598270180264024 GO:0140662 ATP-dependent protein folding chaperone 2/555 40/18639 0.05 1.67918918918919 0.335228984599588 0.598270180264024 GO:0005347 ATP transmembrane transporter activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0008195 phosphatidate phosphatase activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0008494 translation activator activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0008559 ABC-type xenobiotic transporter activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0015386 potassium:proton antiporter activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0019763 immunoglobulin receptor activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0019992 diacylglycerol binding 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0032036 myosin heavy chain binding 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0043176 amine binding 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0046030 inositol trisphosphate phosphatase activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0061665 SUMO ligase activity 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0070742 C2H2 zinc finger domain binding 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0098847 sequence-specific single stranded DNA binding 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:1901612 cardiolipin binding 1/555 14/18639 0.0714285714285714 2.3988416988417 0.345150718445303 0.598270180264024 GO:0016298 lipase activity 5/555 130/18639 0.0384615384615385 1.29168399168399 0.345452534452975 0.598270180264024 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/555 41/18639 0.0487804878048781 1.63823335530653 0.346151767168706 0.598270180264024 GO:0140318 protein transporter activity 2/555 41/18639 0.0487804878048781 1.63823335530653 0.346151767168706 0.598270180264024 GO:0140828 metal cation:monoatomic cation antiporter activity 2/555 41/18639 0.0487804878048781 1.63823335530653 0.346151767168706 0.598270180264024 GO:0008307 structural constituent of muscle 2/555 42/18639 0.0476190476190476 1.5992277992278 0.357014717579838 0.614625337323721 GO:0043175 RNA polymerase core enzyme binding 2/555 42/18639 0.0476190476190476 1.5992277992278 0.357014717579838 0.614625337323721 GO:0005518 collagen binding 3/555 72/18639 0.0416666666666667 1.39932432432432 0.362837228401823 0.615763438757842 GO:0004129 cytochrome-c oxidase activity 1/555 15/18639 0.0666666666666667 2.23891891891892 0.364664348043309 0.615763438757842 GO:0004559 alpha-mannosidase activity 1/555 15/18639 0.0666666666666667 2.23891891891892 0.364664348043309 0.615763438757842 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/555 15/18639 0.0666666666666667 2.23891891891892 0.364664348043309 0.615763438757842 GO:0015929 hexosaminidase activity 1/555 15/18639 0.0666666666666667 2.23891891891892 0.364664348043309 0.615763438757842 GO:0031005 filamin binding 1/555 15/18639 0.0666666666666667 2.23891891891892 0.364664348043309 0.615763438757842 GO:0045504 dynein heavy chain binding 1/555 15/18639 0.0666666666666667 2.23891891891892 0.364664348043309 0.615763438757842 GO:0061578 K63-linked deubiquitinase activity 1/555 15/18639 0.0666666666666667 2.23891891891892 0.364664348043309 0.615763438757842 GO:0120283 protein serine/threonine kinase binding 1/555 15/18639 0.0666666666666667 2.23891891891892 0.364664348043309 0.615763438757842 GO:0141003 histone H2AX kinase activity 12/555 354/18639 0.0338983050847458 1.13843334860284 0.364689052567287 0.615763438757842 GO:0008375 acetylglucosaminyltransferase activity 2/555 43/18639 0.0465116279069767 1.56203645505971 0.367811718988635 0.619843933343611 GO:0140996 histone H3 kinase activity 12/555 357/18639 0.0336134453781513 1.12886668180786 0.375523396884129 0.631627475985182 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/555 44/18639 0.0454545454545455 1.52653562653563 0.378537070505619 0.63308010805138 GO:0004708 MAP kinase kinase activity 1/555 16/18639 0.0625 2.09898648648649 0.38359751421792 0.63308010805138 GO:0005159 insulin-like growth factor receptor binding 1/555 16/18639 0.0625 2.09898648648649 0.38359751421792 0.63308010805138 GO:0008296 3'-5'-DNA exonuclease activity 1/555 16/18639 0.0625 2.09898648648649 0.38359751421792 0.63308010805138 GO:0015923 mannosidase activity 1/555 16/18639 0.0625 2.09898648648649 0.38359751421792 0.63308010805138 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/555 16/18639 0.0625 2.09898648648649 0.38359751421792 0.63308010805138 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/555 16/18639 0.0625 2.09898648648649 0.38359751421792 0.63308010805138 GO:0017070 U6 snRNA binding 1/555 16/18639 0.0625 2.09898648648649 0.38359751421792 0.63308010805138 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/555 16/18639 0.0625 2.09898648648649 0.38359751421792 0.63308010805138 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/555 16/18639 0.0625 2.09898648648649 0.38359751421792 0.63308010805138 GO:0016247 channel regulator activity 6/555 168/18639 0.0357142857142857 1.19942084942085 0.384432811480898 0.633268308593299 GO:0035173 histone kinase activity 12/555 360/18639 0.0333333333333333 1.11945945945946 0.386395050891602 0.635308716634507 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/555 45/18639 0.0444444444444444 1.49261261261261 0.3891854679256 0.638700637081639 GO:0141108 transporter regulator activity 6/555 170/18639 0.0352941176470588 1.18531001589825 0.395088617224068 0.645262825201434 GO:0003924 GTPase activity 11/555 331/18639 0.0332326283987915 1.11607740671185 0.398458563715638 0.645262825201434 GO:0004180 carboxypeptidase activity 2/555 46/18639 0.0434782608695652 1.46016451233843 0.399751985232532 0.645262825201434 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/555 46/18639 0.0434782608695652 1.46016451233843 0.399751985232532 0.645262825201434 GO:0004550 nucleoside diphosphate kinase activity 1/555 17/18639 0.0588235294117647 1.97551669316375 0.401967453519271 0.645262825201434 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/555 17/18639 0.0588235294117647 1.97551669316375 0.401967453519271 0.645262825201434 GO:0015278 intracellularly gated calcium channel activity 1/555 17/18639 0.0588235294117647 1.97551669316375 0.401967453519271 0.645262825201434 GO:0016018 cyclosporin A binding 1/555 17/18639 0.0588235294117647 1.97551669316375 0.401967453519271 0.645262825201434 GO:0036041 long-chain fatty acid binding 1/555 17/18639 0.0588235294117647 1.97551669316375 0.401967453519271 0.645262825201434 GO:0038191 neuropilin binding 1/555 17/18639 0.0588235294117647 1.97551669316375 0.401967453519271 0.645262825201434 GO:0048038 quinone binding 1/555 17/18639 0.0588235294117647 1.97551669316375 0.401967453519271 0.645262825201434 GO:0005504 fatty acid binding 2/555 47/18639 0.0425531914893617 1.42909718228867 0.410232056850865 0.645262825201434 GO:0019199 transmembrane receptor protein kinase activity 3/555 78/18639 0.0384615384615385 1.29168399168399 0.411377294791835 0.645262825201434 GO:0000400 four-way junction DNA binding 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0000900 mRNA regulatory element binding translation repressor activity 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0008409 5'-3' exonuclease activity 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0008525 phosphatidylcholine transporter activity 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0015172 acidic amino acid transmembrane transporter activity 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0017128 phospholipid scramblase activity 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0031690 adrenergic receptor binding 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0034185 apolipoprotein binding 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0035615 clathrin adaptor activity 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0070064 proline-rich region binding 1/555 18/18639 0.0555555555555556 1.86576576576577 0.419790891565496 0.645262825201434 GO:0036121 double-stranded DNA helicase activity 2/555 48/18639 0.0416666666666667 1.39932432432432 0.42062146061544 0.645262825201434 GO:0001222 transcription corepressor binding 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0005004 GPI-linked ephrin receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0005008 hepatocyte growth factor receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0005009 insulin receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0005011 macrophage colony-stimulating factor receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0005020 stem cell factor receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0008288 boss receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0036332 placental growth factor receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0038062 protein tyrosine kinase collagen receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:0060175 brain-derived neurotrophic factor receptor activity 2/555 49/18639 0.0408163265306122 1.3707666850524 0.430916301433017 0.645262825201434 GO:1901681 sulfur compound binding 9/555 275/18639 0.0327272727272727 1.09910565110565 0.434296538535071 0.645262825201434 GO:0015101 organic cation transmembrane transporter activity 3/555 81/18639 0.037037037037037 1.24384384384384 0.435229583399131 0.645262825201434 GO:0030971 receptor tyrosine kinase binding 3/555 81/18639 0.037037037037037 1.24384384384384 0.435229583399131 0.645262825201434 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 8/555 243/18639 0.0329218106995885 1.10563897230564 0.437074754913292 0.645262825201434 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:0005520 insulin-like growth factor binding 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:0022821 solute:potassium antiporter activity 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:0030506 ankyrin binding 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:0042577 lipid phosphatase activity 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:0046624 sphingolipid transporter activity 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:0050145 nucleoside monophosphate kinase activity 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:0070003 threonine-type peptidase activity 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:1990380 K48-linked deubiquitinase activity 1/555 19/18639 0.0526315789473684 1.76756756756757 0.437084058161337 0.645262825201434 GO:0005006 epidermal growth factor receptor activity 2/555 50/18639 0.04 1.34335135135135 0.44111299560944 0.645262825201434 GO:0005007 fibroblast growth factor receptor activity 2/555 50/18639 0.04 1.34335135135135 0.44111299560944 0.645262825201434 GO:0005017 platelet-derived growth factor receptor activity 2/555 50/18639 0.04 1.34335135135135 0.44111299560944 0.645262825201434 GO:0005019 platelet-derived growth factor beta-receptor activity 2/555 50/18639 0.04 1.34335135135135 0.44111299560944 0.645262825201434 GO:0015605 organophosphate ester transmembrane transporter activity 2/555 50/18639 0.04 1.34335135135135 0.44111299560944 0.645262825201434 GO:0004676 3-phosphoinositide-dependent protein kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0004711 ribosomal protein S6 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0035175 histone H3S10 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0035979 histone H2AXS139 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0044022 histone H3S28 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0044023 histone H4S1 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0044024 histone H2AS1 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0044025 histone H2BS14 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0072354 histone H3T3 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0072371 histone H2AS121 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0072518 Rho-dependent protein serine/threonine kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0140823 histone H2BS36 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0140855 histone H3S57 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0140995 histone H2A kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0140997 histone H4 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0140998 histone H2B kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:1990244 histone H2AT120 kinase activity 8/555 245/18639 0.0326530612244898 1.09661334804192 0.446098559108508 0.645262825201434 GO:0016853 isomerase activity 6/555 180/18639 0.0333333333333333 1.11945945945946 0.448116396306228 0.646265658413853 GO:0004677 DNA-dependent protein kinase activity 8/555 246/18639 0.032520325203252 1.09215557020435 0.450602611107067 0.646265658413853 GO:0140857 histone H3T45 kinase activity 8/555 246/18639 0.032520325203252 1.09215557020435 0.450602611107067 0.646265658413853 GO:0005021 vascular endothelial growth factor receptor activity 2/555 51/18639 0.0392156862745098 1.31701112877583 0.451208255817417 0.646265658413853 GO:0005030 neurotrophin receptor activity 2/555 51/18639 0.0392156862745098 1.31701112877583 0.451208255817417 0.646265658413853 GO:0005048 signal sequence binding 2/555 51/18639 0.0392156862745098 1.31701112877583 0.451208255817417 0.646265658413853 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/555 20/18639 0.05 1.67918918918919 0.453862701970169 0.646567026950318 GO:0031418 L-ascorbic acid binding 1/555 20/18639 0.05 1.67918918918919 0.453862701970169 0.646567026950318 GO:0052745 inositol phosphate phosphatase activity 1/555 20/18639 0.05 1.67918918918919 0.453862701970169 0.646567026950318 GO:0035402 histone H3T11 kinase activity 8/555 247/18639 0.0323886639676113 1.08773388773389 0.455100709174597 0.646567026950318 GO:0035403 histone H3T6 kinase activity 8/555 247/18639 0.0323886639676113 1.08773388773389 0.455100709174597 0.646567026950318 GO:0004679 AMP-activated protein kinase activity 8/555 248/18639 0.032258064516129 1.08334786399303 0.459592321090042 0.65189346997909 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/555 21/18639 0.0476190476190476 1.5992277992278 0.470142104752626 0.659666074953274 GO:0001846 opsonin binding 1/555 21/18639 0.0476190476190476 1.5992277992278 0.470142104752626 0.659666074953274 GO:0036122 BMP binding 1/555 21/18639 0.0476190476190476 1.5992277992278 0.470142104752626 0.659666074953274 GO:0140312 cargo adaptor activity 1/555 21/18639 0.0476190476190476 1.5992277992278 0.470142104752626 0.659666074953274 GO:0004864 protein phosphatase inhibitor activity 2/555 53/18639 0.0377358490566038 1.26731259561448 0.471082720951825 0.659666074953274 GO:0005003 ephrin receptor activity 2/555 53/18639 0.0377358490566038 1.26731259561448 0.471082720951825 0.659666074953274 GO:0005005 transmembrane-ephrin receptor activity 2/555 53/18639 0.0377358490566038 1.26731259561448 0.471082720951825 0.659666074953274 GO:0005246 calcium channel regulator activity 2/555 53/18639 0.0377358490566038 1.26731259561448 0.471082720951825 0.659666074953274 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/555 54/18639 0.037037037037037 1.24384384384384 0.48085670625965 0.671211745780561 GO:0140463 chromatin-protein adaptor activity 2/555 54/18639 0.037037037037037 1.24384384384384 0.48085670625965 0.671211745780561 GO:0008093 cytoskeletal anchor activity 1/555 22/18639 0.0454545454545455 1.52653562653563 0.485937095184589 0.671894125310345 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/555 22/18639 0.0454545454545455 1.52653562653563 0.485937095184589 0.671894125310345 GO:0031683 G-protein beta/gamma-subunit complex binding 1/555 22/18639 0.0454545454545455 1.52653562653563 0.485937095184589 0.671894125310345 GO:0033691 sialic acid binding 1/555 22/18639 0.0454545454545455 1.52653562653563 0.485937095184589 0.671894125310345 GO:0050321 tau-protein kinase activity 1/555 22/18639 0.0454545454545455 1.52653562653563 0.485937095184589 0.671894125310345 GO:0070034 telomerase RNA binding 1/555 22/18639 0.0454545454545455 1.52653562653563 0.485937095184589 0.671894125310345 GO:0019212 phosphatase inhibitor activity 2/555 56/18639 0.0357142857142857 1.19942084942085 0.500066969197128 0.684460483157688 GO:0005212 structural constituent of eye lens 1/555 23/18639 0.0434782608695652 1.46016451233843 0.501262062266963 0.684460483157688 GO:0005283 amino acid:sodium symporter activity 1/555 23/18639 0.0434782608695652 1.46016451233843 0.501262062266963 0.684460483157688 GO:0016493 C-C chemokine receptor activity 1/555 23/18639 0.0434782608695652 1.46016451233843 0.501262062266963 0.684460483157688 GO:0016849 phosphorus-oxygen lyase activity 1/555 23/18639 0.0434782608695652 1.46016451233843 0.501262062266963 0.684460483157688 GO:0016917 GABA receptor activity 1/555 23/18639 0.0434782608695652 1.46016451233843 0.501262062266963 0.684460483157688 GO:0017134 fibroblast growth factor binding 1/555 23/18639 0.0434782608695652 1.46016451233843 0.501262062266963 0.684460483157688 GO:0140103 catalytic activity, acting on a glycoprotein 1/555 23/18639 0.0434782608695652 1.46016451233843 0.501262062266963 0.684460483157688 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/555 57/18639 0.0350877192982456 1.17837837837838 0.509499444764928 0.6946281250056 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/555 91/18639 0.032967032967033 1.10715770715771 0.51176904709656 0.696640656357798 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/555 24/18639 0.0416666666666667 1.39932432432432 0.516130968339257 0.697173831079797 GO:0004806 triacylglycerol lipase activity 1/555 24/18639 0.0416666666666667 1.39932432432432 0.516130968339257 0.697173831079797 GO:0005315 phosphate transmembrane transporter activity 1/555 24/18639 0.0416666666666667 1.39932432432432 0.516130968339257 0.697173831079797 GO:0019957 C-C chemokine binding 1/555 24/18639 0.0416666666666667 1.39932432432432 0.516130968339257 0.697173831079797 GO:0050699 WW domain binding 1/555 24/18639 0.0416666666666667 1.39932432432432 0.516130968339257 0.697173831079797 GO:0099106 ion channel regulator activity 5/555 160/18639 0.03125 1.04949324324324 0.51991146382478 0.701201636310533 GO:0004866 endopeptidase inhibitor activity 5/555 161/18639 0.031055900621118 1.0429746516703 0.525447183809379 0.706699271652642 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 7/555 229/18639 0.0305676855895196 1.02657854360911 0.525597522083343 0.706699271652642 GO:0051213 dioxygenase activity 3/555 93/18639 0.032258064516129 1.08334786399303 0.526419619713717 0.706722364080494 GO:0031593 polyubiquitin modification-dependent protein binding 2/555 59/18639 0.0338983050847458 1.13843334860284 0.528011149847208 0.706873085857689 GO:0001848 complement binding 1/555 25/18639 0.04 1.34335135135135 0.530557361708675 0.706873085857689 GO:0003707 nuclear steroid receptor activity 1/555 25/18639 0.04 1.34335135135135 0.530557361708675 0.706873085857689 GO:0005251 delayed rectifier potassium channel activity 1/555 25/18639 0.04 1.34335135135135 0.530557361708675 0.706873085857689 GO:0008139 nuclear localization sequence binding 1/555 25/18639 0.04 1.34335135135135 0.530557361708675 0.706873085857689 GO:0001098 basal transcription machinery binding 2/555 60/18639 0.0333333333333333 1.11945945945946 0.537087789032895 0.711486240267113 GO:0001099 basal RNA polymerase II transcription machinery binding 2/555 60/18639 0.0333333333333333 1.11945945945946 0.537087789032895 0.711486240267113 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/555 60/18639 0.0333333333333333 1.11945945945946 0.537087789032895 0.711486240267113 GO:0016798 hydrolase activity, acting on glycosyl bonds 4/555 130/18639 0.0307692307692308 1.03334719334719 0.544170459910829 0.711486240267113 GO:0001637 G protein-coupled chemoattractant receptor activity 1/555 26/18639 0.0384615384615385 1.29168399168399 0.544554388906037 0.711486240267113 GO:0004950 chemokine receptor activity 1/555 26/18639 0.0384615384615385 1.29168399168399 0.544554388906037 0.711486240267113 GO:0005112 Notch binding 1/555 26/18639 0.0384615384615385 1.29168399168399 0.544554388906037 0.711486240267113 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/555 26/18639 0.0384615384615385 1.29168399168399 0.544554388906037 0.711486240267113 GO:0008198 ferrous iron binding 1/555 26/18639 0.0384615384615385 1.29168399168399 0.544554388906037 0.711486240267113 GO:0034237 protein kinase A regulatory subunit binding 1/555 26/18639 0.0384615384615385 1.29168399168399 0.544554388906037 0.711486240267113 GO:0050681 nuclear androgen receptor binding 1/555 26/18639 0.0384615384615385 1.29168399168399 0.544554388906037 0.711486240267113 GO:0070006 metalloaminopeptidase activity 1/555 26/18639 0.0384615384615385 1.29168399168399 0.544554388906037 0.711486240267113 GO:0097602 cullin family protein binding 1/555 26/18639 0.0384615384615385 1.29168399168399 0.544554388906037 0.711486240267113 GO:0015026 coreceptor activity 2/555 61/18639 0.0327868852459016 1.10110766504209 0.5460435262628 0.712371792063504 GO:0016829 lyase activity 6/555 200/18639 0.03 1.00751351351351 0.550267218170401 0.716816939990523 GO:0008395 steroid hydroxylase activity 1/555 27/18639 0.037037037037037 1.24384384384384 0.558134806579552 0.724914733989418 GO:0016405 CoA-ligase activity 1/555 27/18639 0.037037037037037 1.24384384384384 0.558134806579552 0.724914733989418 GO:1901682 sulfur compound transmembrane transporter activity 2/555 63/18639 0.0317460317460317 1.06615186615187 0.56358901791632 0.730917515111564 GO:0030414 peptidase inhibitor activity 5/555 169/18639 0.029585798816568 0.993603070526147 0.568669028963967 0.736418005059533 GO:0005242 inward rectifier potassium channel activity 1/555 28/18639 0.0357142857142857 1.19942084942085 0.571310993037125 0.736580105560347 GO:0046966 nuclear thyroid hormone receptor binding 1/555 28/18639 0.0357142857142857 1.19942084942085 0.571310993037125 0.736580105560347 GO:0141052 histone H3 demethylase activity 1/555 28/18639 0.0357142857142857 1.19942084942085 0.571310993037125 0.736580105560347 GO:0004536 DNA nuclease activity 2/555 64/18639 0.03125 1.04949324324324 0.572177520177195 0.736615634480318 GO:0008017 microtubule binding 8/555 276/18639 0.0289855072463768 0.973443008225617 0.580787506298432 0.744318395348255 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/555 29/18639 0.0344827586206897 1.15806150978565 0.584094959447549 0.744318395348255 GO:0005416 amino acid:monoatomic cation symporter activity 1/555 29/18639 0.0344827586206897 1.15806150978565 0.584094959447549 0.744318395348255 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/555 29/18639 0.0344827586206897 1.15806150978565 0.584094959447549 0.744318395348255 GO:0097472 cyclin-dependent protein kinase activity 1/555 29/18639 0.0344827586206897 1.15806150978565 0.584094959447549 0.744318395348255 GO:0099604 ligand-gated calcium channel activity 1/555 29/18639 0.0344827586206897 1.15806150978565 0.584094959447549 0.744318395348255 GO:0106222 lncRNA binding 1/555 29/18639 0.0344827586206897 1.15806150978565 0.584094959447549 0.744318395348255 GO:0001217 DNA-binding transcription repressor activity 8/555 278/18639 0.0287769784172662 0.96643982111608 0.588977425840104 0.748625292049745 GO:0015171 amino acid transmembrane transporter activity 3/555 102/18639 0.0294117647058824 0.987758346581876 0.589180041920699 0.748625292049745 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/555 30/18639 0.0333333333333333 1.11945945945946 0.596498360710666 0.753366267040857 GO:0008187 poly-pyrimidine tract binding 1/555 30/18639 0.0333333333333333 1.11945945945946 0.596498360710666 0.753366267040857 GO:0032452 histone demethylase activity 1/555 30/18639 0.0333333333333333 1.11945945945946 0.596498360710666 0.753366267040857 GO:0051721 protein phosphatase 2A binding 1/555 30/18639 0.0333333333333333 1.11945945945946 0.596498360710666 0.753366267040857 GO:0016500 protein-hormone receptor activity 2/555 67/18639 0.0298507462686567 1.00250100847116 0.597201505535805 0.753366267040857 GO:0003735 structural constituent of ribosome 5/555 175/18639 0.0285714285714286 0.959536679536679 0.599713905905417 0.755450228672821 GO:0022804 active transmembrane transporter activity 13/555 457/18639 0.0284463894967177 0.955337394287066 0.60648768191803 0.75893684697939 GO:0005452 solute:inorganic anion antiporter activity 1/555 31/18639 0.032258064516129 1.08334786399303 0.608532506006253 0.75893684697939 GO:0008327 methyl-CpG binding 1/555 31/18639 0.032258064516129 1.08334786399303 0.608532506006253 0.75893684697939 GO:0016878 acid-thiol ligase activity 1/555 31/18639 0.032258064516129 1.08334786399303 0.608532506006253 0.75893684697939 GO:0047499 calcium-independent phospholipase A2 activity 1/555 31/18639 0.032258064516129 1.08334786399303 0.608532506006253 0.75893684697939 GO:0070273 phosphatidylinositol-4-phosphate binding 1/555 31/18639 0.032258064516129 1.08334786399303 0.608532506006253 0.75893684697939 GO:0140457 protein demethylase activity 1/555 31/18639 0.032258064516129 1.08334786399303 0.608532506006253 0.75893684697939 GO:0002039 p53 binding 2/555 69/18639 0.0289855072463768 0.973443008225617 0.61326498529981 0.7637541235365 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/555 32/18639 0.03125 1.04949324324324 0.62020836903111 0.768043650224703 GO:0042910 xenobiotic transmembrane transporter activity 1/555 32/18639 0.03125 1.04949324324324 0.62020836903111 0.768043650224703 GO:0047498 calcium-dependent phospholipase A2 activity 1/555 32/18639 0.03125 1.04949324324324 0.62020836903111 0.768043650224703 GO:0051059 NF-kappaB binding 1/555 32/18639 0.03125 1.04949324324324 0.62020836903111 0.768043650224703 GO:0005543 phospholipid binding 14/555 497/18639 0.028169014084507 0.946022078416445 0.622353513008531 0.769614625945761 GO:0019956 chemokine binding 1/555 33/18639 0.0303030303030303 1.01769041769042 0.631536597933552 0.778776872170869 GO:0042923 neuropeptide binding 1/555 33/18639 0.0303030303030303 1.01769041769042 0.631536597933552 0.778776872170869 GO:0008175 tRNA methyltransferase activity 1/555 34/18639 0.0294117647058824 0.987758346581876 0.642527524954237 0.787903864399191 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/555 34/18639 0.0294117647058824 0.987758346581876 0.642527524954237 0.787903864399191 GO:0016831 carboxy-lyase activity 1/555 34/18639 0.0294117647058824 0.987758346581876 0.642527524954237 0.787903864399191 GO:0051427 hormone receptor binding 1/555 34/18639 0.0294117647058824 0.987758346581876 0.642527524954237 0.787903864399191 GO:0042578 phosphoric ester hydrolase activity 10/555 363/18639 0.0275482093663912 0.925173106991289 0.643450408652663 0.787935088977738 GO:0019001 guanyl nucleotide binding 11/555 400/18639 0.0275 0.923554054054054 0.64860190566794 0.788860869788982 GO:0032561 guanyl ribonucleotide binding 11/555 400/18639 0.0275 0.923554054054054 0.64860190566794 0.788860869788982 GO:0003678 DNA helicase activity 2/555 74/18639 0.027027027027027 0.907669831994156 0.651266838760193 0.788860869788982 GO:0035064 methylated histone binding 2/555 74/18639 0.027027027027027 0.907669831994156 0.651266838760193 0.788860869788982 GO:0043022 ribosome binding 3/555 112/18639 0.0267857142857143 0.899565637065637 0.652329189891245 0.788860869788982 GO:0004623 phospholipase A2 activity 1/555 35/18639 0.0285714285714286 0.959536679536679 0.653191175781993 0.788860869788982 GO:0005343 organic acid:sodium symporter activity 1/555 35/18639 0.0285714285714286 0.959536679536679 0.653191175781993 0.788860869788982 GO:0016229 steroid dehydrogenase activity 1/555 35/18639 0.0285714285714286 0.959536679536679 0.653191175781993 0.788860869788982 GO:0043015 gamma-tubulin binding 1/555 35/18639 0.0285714285714286 0.959536679536679 0.653191175781993 0.788860869788982 GO:0061631 ubiquitin conjugating enzyme activity 1/555 35/18639 0.0285714285714286 0.959536679536679 0.653191175781993 0.788860869788982 GO:0004190 aspartic-type endopeptidase activity 1/555 36/18639 0.0277777777777778 0.932882882882883 0.663537278633046 0.80025512450524 GO:0140034 methylation-dependent protein binding 2/555 76/18639 0.0263157894736842 0.883783783783784 0.665614403048438 0.801659047841603 GO:0070001 aspartic-type peptidase activity 1/555 37/18639 0.027027027027027 0.907669831994156 0.67357527306183 0.810135739381215 GO:0005506 iron ion binding 4/555 154/18639 0.025974025974026 0.872306072306072 0.676930728710269 0.813057701515207 GO:0000146 microfilament motor activity 1/555 38/18639 0.0263157894736842 0.883783783783784 0.683314318511281 0.819541603218631 GO:0000287 magnesium ion binding 6/555 230/18639 0.0260869565217391 0.876098707403055 0.684779616494132 0.819541603218631 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 7/555 268/18639 0.0261194029850746 0.877188382412263 0.689614682337163 0.819541603218631 GO:0005525 GTP binding 10/555 378/18639 0.0264550264550265 0.888459888459888 0.69247094344872 0.819541603218631 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/555 39/18639 0.0256410256410256 0.861122661122661 0.692763302610321 0.819541603218631 GO:0000049 tRNA binding 2/555 80/18639 0.025 0.839594594594595 0.692877780829425 0.819541603218631 GO:0033192 calmodulin-dependent protein phosphatase activity 2/555 81/18639 0.0246913580246914 0.829229229229229 0.699400520004875 0.819541603218631 GO:0140791 histone H2AXS140 phosphatase activity 2/555 81/18639 0.0246913580246914 0.829229229229229 0.699400520004875 0.819541603218631 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 2/555 81/18639 0.0246913580246914 0.829229229229229 0.699400520004875 0.819541603218631 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 2/555 81/18639 0.0246913580246914 0.829229229229229 0.699400520004875 0.819541603218631 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 2/555 81/18639 0.0246913580246914 0.829229229229229 0.699400520004875 0.819541603218631 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 2/555 81/18639 0.0246913580246914 0.829229229229229 0.699400520004875 0.819541603218631 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 2/555 81/18639 0.0246913580246914 0.829229229229229 0.699400520004875 0.819541603218631 GO:1990439 MAP kinase serine/threonine phosphatase activity 2/555 81/18639 0.0246913580246914 0.829229229229229 0.699400520004875 0.819541603218631 GO:0004177 aminopeptidase activity 1/555 40/18639 0.025 0.839594594594595 0.70193084922598 0.819541603218631 GO:0030331 nuclear estrogen receptor binding 1/555 40/18639 0.025 0.839594594594595 0.70193084922598 0.819541603218631 GO:0032451 demethylase activity 1/555 40/18639 0.025 0.839594594594595 0.70193084922598 0.819541603218631 GO:0061791 GTPase motor activity 1/555 40/18639 0.025 0.839594594594595 0.70193084922598 0.819541603218631 GO:0071855 neuropeptide receptor binding 1/555 40/18639 0.025 0.839594594594595 0.70193084922598 0.819541603218631 GO:0071949 FAD binding 1/555 40/18639 0.025 0.839594594594595 0.70193084922598 0.819541603218631 GO:1990606 membrane scission GTPase motor activity 1/555 40/18639 0.025 0.839594594594595 0.70193084922598 0.819541603218631 GO:0003697 single-stranded DNA binding 3/555 121/18639 0.0247933884297521 0.83265579629216 0.702968167733244 0.819662750690289 GO:0015079 potassium ion transmembrane transporter activity 4/555 160/18639 0.025 0.839594594594595 0.705564040222967 0.819708228366632 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 2/555 82/18639 0.024390243902439 0.819116677653263 0.705807996179013 0.819708228366632 GO:0033549 MAP kinase phosphatase activity 2/555 82/18639 0.024390243902439 0.819116677653263 0.705807996179013 0.819708228366632 GO:0008528 G protein-coupled peptide receptor activity 3/555 122/18639 0.0245901639344262 0.825830748781568 0.708232271812651 0.82143716598614 GO:0001727 lipid kinase activity 1/555 41/18639 0.024390243902439 0.819116677653263 0.710825326277412 0.821583338605496 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/555 41/18639 0.024390243902439 0.819116677653263 0.710825326277412 0.821583338605496 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2/555 83/18639 0.0240963855421687 0.809247802018886 0.712101276399524 0.821583338605496 GO:0030165 PDZ domain binding 2/555 83/18639 0.0240963855421687 0.809247802018886 0.712101276399524 0.821583338605496 GO:0017018 myosin phosphatase activity 2/555 84/18639 0.0238095238095238 0.7996138996139 0.718281466408553 0.823574134568345 GO:0005267 potassium channel activity 3/555 124/18639 0.0241935483870968 0.812510897994769 0.718545340167692 0.823574134568345 GO:0019894 kinesin binding 1/555 42/18639 0.0238095238095238 0.7996138996139 0.719454853318817 0.823574134568345 GO:0031492 nucleosomal DNA binding 1/555 42/18639 0.0238095238095238 0.7996138996139 0.719454853318817 0.823574134568345 GO:0048487 beta-tubulin binding 1/555 42/18639 0.0238095238095238 0.7996138996139 0.719454853318817 0.823574134568345 GO:0051879 Hsp90 protein binding 1/555 42/18639 0.0238095238095238 0.7996138996139 0.719454853318817 0.823574134568345 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 2/555 86/18639 0.0232558139534884 0.781018227529856 0.730307172946882 0.834908460738753 GO:0001223 transcription coactivator binding 1/555 44/18639 0.0227272727272727 0.763267813267813 0.735950337697932 0.838815926506042 GO:0019205 nucleobase-containing compound kinase activity 1/555 44/18639 0.0227272727272727 0.763267813267813 0.735950337697932 0.838815926506042 GO:0016874 ligase activity 4/555 167/18639 0.0239520958083832 0.804402006797216 0.73659120653321 0.838815926506042 GO:0001653 peptide receptor activity 3/555 128/18639 0.0234375 0.787119932432432 0.738319588700304 0.839695076267963 GO:0051539 4 iron, 4 sulfur cluster binding 1/555 45/18639 0.0222222222222222 0.746306306306306 0.743831357465485 0.843777689734749 GO:0140303 intramembrane lipid transporter activity 1/555 45/18639 0.0222222222222222 0.746306306306306 0.743831357465485 0.843777689734749 GO:0035091 phosphatidylinositol binding 7/555 284/18639 0.0246478873239437 0.827769318614389 0.745188121401883 0.844226026568842 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 2/555 89/18639 0.0224719101123595 0.754691770422108 0.747527077585336 0.844695976988321 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 2/555 89/18639 0.0224719101123595 0.754691770422108 0.747527077585336 0.844695976988321 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/555 46/18639 0.0217391304347826 0.730082256169213 0.751477565737328 0.846979849444639 GO:0030276 clathrin binding 1/555 46/18639 0.0217391304347826 0.730082256169213 0.751477565737328 0.846979849444639 GO:0140793 histone H2AXY142 phosphatase activity 2/555 90/18639 0.0222222222222222 0.746306306306306 0.75305372484972 0.847668167202634 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3/555 132/18639 0.0227272727272727 0.763267813267813 0.756978013244386 0.849886021567256 GO:0043495 protein-membrane adaptor activity 1/555 47/18639 0.0212765957446809 0.714548591144336 0.758895946365295 0.849886021567256 GO:0061749 forked DNA-dependent helicase activity 1/555 47/18639 0.0212765957446809 0.714548591144336 0.758895946365295 0.849886021567256 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/555 47/18639 0.0212765957446809 0.714548591144336 0.758895946365295 0.849886021567256 GO:0009378 four-way junction helicase activity 1/555 48/18639 0.0208333333333333 0.699662162162162 0.766093275849334 0.85359123882705 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/555 48/18639 0.0208333333333333 0.699662162162162 0.766093275849334 0.85359123882705 GO:0032266 phosphatidylinositol-3-phosphate binding 1/555 48/18639 0.0208333333333333 0.699662162162162 0.766093275849334 0.85359123882705 GO:0043138 3'-5' DNA helicase activity 1/555 48/18639 0.0208333333333333 0.699662162162162 0.766093275849334 0.85359123882705 GO:0015297 antiporter activity 3/555 135/18639 0.0222222222222222 0.746306306306306 0.770256631758779 0.857142360816487 GO:0046982 protein heterodimerization activity 9/555 369/18639 0.024390243902439 0.819116677653263 0.7735708959124 0.859740818495047 GO:0003743 translation initiation factor activity 1/555 51/18639 0.0196078431372549 0.658505564387917 0.786423739947157 0.86962222125139 GO:0005272 sodium channel activity 1/555 51/18639 0.0196078431372549 0.658505564387917 0.786423739947157 0.86962222125139 GO:0016597 amino acid binding 1/555 51/18639 0.0196078431372549 0.658505564387917 0.786423739947157 0.86962222125139 GO:0016830 carbon-carbon lyase activity 1/555 51/18639 0.0196078431372549 0.658505564387917 0.786423739947157 0.86962222125139 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 4/555 181/18639 0.0220994475138122 0.742183067044946 0.79112877858281 0.873724613327933 GO:0004725 protein tyrosine phosphatase activity 2/555 98/18639 0.0204081632653061 0.6853833425262 0.793615933883798 0.874272007465464 GO:0005249 voltage-gated potassium channel activity 2/555 98/18639 0.0204081632653061 0.6853833425262 0.793615933883798 0.874272007465464 GO:0003730 mRNA 3'-UTR binding 6/555 262/18639 0.0229007633587786 0.769094285124819 0.795989432702988 0.874702111826114 GO:0005544 calcium-dependent phospholipid binding 1/555 53/18639 0.0188679245283019 0.633656297807241 0.798987578228409 0.874702111826114 GO:0008146 sulfotransferase activity 1/555 53/18639 0.0188679245283019 0.633656297807241 0.798987578228409 0.874702111826114 GO:0051018 protein kinase A binding 1/555 53/18639 0.0188679245283019 0.633656297807241 0.798987578228409 0.874702111826114 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/555 53/18639 0.0188679245283019 0.633656297807241 0.798987578228409 0.874702111826114 GO:1901981 phosphatidylinositol phosphate binding 4/555 185/18639 0.0216216216216216 0.726135865595325 0.804940679299547 0.877989144986976 GO:0015485 cholesterol binding 1/555 54/18639 0.0185185185185185 0.621921921921922 0.804990047510838 0.877989144986976 GO:0050661 NADP binding 1/555 54/18639 0.0185185185185185 0.621921921921922 0.804990047510838 0.877989144986976 GO:0016757 glycosyltransferase activity 6/555 267/18639 0.0224719101123595 0.754691770422108 0.810286594199697 0.882669515765923 GO:0008238 exopeptidase activity 2/555 102/18639 0.0196078431372549 0.658505564387917 0.811604010006238 0.8830090716053 GO:0015631 tubulin binding 9/555 385/18639 0.0233766233766234 0.785075465075465 0.813467406434266 0.883941067882779 GO:0004722 protein serine/threonine phosphatase activity 2/555 103/18639 0.0194174757281553 0.652112306481239 0.815877050910835 0.885006144969055 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/555 56/18639 0.0178571428571429 0.599710424710425 0.816463527818832 0.885006144969055 GO:0016791 phosphatase activity 6/555 273/18639 0.021978021978022 0.738105138105138 0.826396608121209 0.893295562377506 GO:0017116 single-stranded DNA helicase activity 1/555 58/18639 0.0172413793103448 0.579030754892824 0.827263106405448 0.893295562377506 GO:0004497 monooxygenase activity 2/555 106/18639 0.0188679245283019 0.633656297807241 0.828180623889852 0.893295562377506 GO:0008013 beta-catenin binding 2/555 106/18639 0.0188679245283019 0.633656297807241 0.828180623889852 0.893295562377506 GO:0036002 pre-mRNA binding 1/555 59/18639 0.0169491525423729 0.56921667430142 0.832422622897831 0.896769402336559 GO:0005496 steroid binding 2/555 108/18639 0.0185185185185185 0.621921921921922 0.835967032848129 0.899484135834139 GO:1902936 phosphatidylinositol bisphosphate binding 2/555 111/18639 0.018018018018018 0.605113221329437 0.847049706151958 0.910293319463182 GO:0005507 copper ion binding 1/555 63/18639 0.0158730158730159 0.533075933075933 0.851567389753863 0.91402954548153 GO:0008235 metalloexopeptidase activity 1/555 66/18639 0.0151515151515152 0.508845208845209 0.864478806628562 0.926755057655528 GO:0005516 calmodulin binding 4/555 207/18639 0.0193236714975845 0.648962005483745 0.868147548041404 0.928828246352773 GO:0008173 RNA methyltransferase activity 1/555 67/18639 0.0149253731343284 0.501250504235579 0.868528462705725 0.928828246352773 GO:0032934 sterol binding 1/555 68/18639 0.0147058823529412 0.493879173290938 0.872457318143929 0.931894799671982 GO:0098960 postsynaptic neurotransmitter receptor activity 1/555 69/18639 0.0144927536231884 0.486721504112808 0.876268970097519 0.934828864818495 GO:0016782 transferase activity, transferring sulphur-containing groups 1/555 70/18639 0.0142857142857143 0.47976833976834 0.87996690879412 0.937625830777226 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/555 122/18639 0.0163934426229508 0.550553832521046 0.882094460389509 0.937625830777226 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/555 122/18639 0.0163934426229508 0.550553832521046 0.882094460389509 0.937625830777226 GO:0140299 molecular sensor activity 1/555 71/18639 0.0140845070422535 0.473011039208222 0.883554520707484 0.938042163459699 GO:0031491 nucleosome binding 1/555 74/18639 0.0135135135135135 0.453834915997078 0.893687768198064 0.947654420867029 GO:0019003 GDP binding 1/555 75/18639 0.0133333333333333 0.447783783783784 0.896865968502404 0.949706136223588 GO:0004252 serine-type endopeptidase activity 3/555 176/18639 0.0170454545454545 0.57245085995086 0.898831360526291 0.949706136223588 GO:0017022 myosin binding 1/555 76/18639 0.0131578947368421 0.441891891891892 0.899949322708457 0.949706136223588 GO:0051536 iron-sulfur cluster binding 1/555 76/18639 0.0131578947368421 0.441891891891892 0.899949322708457 0.949706136223588 GO:0051540 metal cluster binding 1/555 77/18639 0.012987012987013 0.436153036153036 0.902940656323541 0.951718963087718 GO:0015370 solute:sodium symporter activity 1/555 79/18639 0.0126582278481013 0.425111187136504 0.908658146177295 0.955451320172054 GO:0016835 carbon-oxygen lyase activity 1/555 79/18639 0.0126582278481013 0.425111187136504 0.908658146177295 0.955451320172054 GO:0099094 ligand-gated monoatomic cation channel activity 2/555 136/18639 0.0147058823529412 0.493879173290938 0.915972491646181 0.9608409171629 GO:0140789 histone phosphatase activity 2/555 136/18639 0.0147058823529412 0.493879173290938 0.915972491646181 0.9608409171629 GO:0051117 ATPase binding 1/555 84/18639 0.0119047619047619 0.39980694980695 0.921523725674632 0.963638767221448 GO:0046943 carboxylic acid transmembrane transporter activity 3/555 188/18639 0.0159574468085106 0.535911443358252 0.921646282145097 0.963638767221448 GO:0140767 enzyme-substrate adaptor activity 2/555 139/18639 0.0143884892086331 0.48321991055804 0.921932305769951 0.963638767221448 GO:0005342 organic acid transmembrane transporter activity 3/555 189/18639 0.0158730158730159 0.533075933075933 0.923317957440882 0.963939556044107 GO:0050660 flavin adenine dinucleotide binding 1/555 86/18639 0.0116279069767442 0.390509113764928 0.926148257327373 0.965746045051584 GO:0022843 voltage-gated monoatomic cation channel activity 2/555 143/18639 0.013986013986014 0.46970326970327 0.929261570669606 0.967843011919233 GO:0008236 serine-type peptidase activity 3/555 194/18639 0.0154639175257732 0.519336862635832 0.931197093994962 0.96870977313694 GO:0008194 UDP-glycosyltransferase activity 2/555 145/18639 0.0137931034482759 0.463224603914259 0.932677850774191 0.969101956189041 GO:0016758 hexosyltransferase activity 3/555 197/18639 0.0152284263959391 0.511428179448484 0.93556026621836 0.970947888581229 GO:0017171 serine hydrolase activity 3/555 198/18639 0.0151515151515152 0.508845208845209 0.936957026323781 0.971249432245903 GO:0043178 alcohol binding 1/555 92/18639 0.0108695652173913 0.365041128084606 0.938452483210758 0.971652453135667 GO:0019842 vitamin binding 2/555 150/18639 0.0133333333333333 0.447783783783784 0.940548408431808 0.972675503655038 GO:0003774 cytoskeletal motor activity 2/555 153/18639 0.0130718954248366 0.439003709591945 0.944842994977442 0.975493993022549 GO:0016407 acetyltransferase activity 1/555 96/18639 0.0104166666666667 0.349831081081081 0.945495886175614 0.975493993022549 GO:0030594 neurotransmitter receptor activity 1/555 97/18639 0.0103092783505155 0.346224575090554 0.947127217846462 0.976030161114077 GO:0030527 structural constituent of chromatin 1/555 98/18639 0.0102040816326531 0.3426916712631 0.948709808402778 0.976514902435685 GO:0005253 monoatomic anion channel activity 1/555 103/18639 0.00970873786407767 0.326056153240619 0.955941037293287 0.982805890800358 GO:0015081 sodium ion transmembrane transporter activity 2/555 164/18639 0.0121951219512195 0.409558338826632 0.95819732560948 0.983973394017688 GO:0008514 organic anion transmembrane transporter activity 4/555 269/18639 0.0148698884758364 0.499387119461469 0.961012972729237 0.985711904271344 GO:0005244 voltage-gated monoatomic ion channel activity 2/555 173/18639 0.0115606936416185 0.38825183565068 0.966763648962635 0.989844222424134 GO:0004721 phosphoprotein phosphatase activity 2/555 175/18639 0.0114285714285714 0.383814671814672 0.968423903260059 0.989844222424134 GO:0022832 voltage-gated channel activity 2/555 175/18639 0.0114285714285714 0.383814671814672 0.968423903260059 0.989844222424134 GO:0015294 solute:monoatomic cation symporter activity 1/555 116/18639 0.00862068965517241 0.289515377446412 0.970327817084158 0.990637003953362 GO:0015291 secondary active transmembrane transporter activity 4/555 287/18639 0.0139372822299652 0.468066672944722 0.973319081680351 0.992536763897036 GO:0005261 monoatomic cation channel activity 5/555 341/18639 0.0146627565982405 0.492430847269557 0.976022772541109 0.993188324074172 GO:0015276 ligand-gated monoatomic ion channel activity 2/555 186/18639 0.010752688172043 0.361115954664342 0.976220414209579 0.993188324074172 GO:0022834 ligand-gated channel activity 2/555 188/18639 0.0106382978723404 0.357274295572168 0.9774221969417 0.993260056614366 GO:0005262 calcium channel activity 1/555 131/18639 0.00763358778625954 0.256364761708273 0.981202521457319 0.995522314675739 GO:0046873 metal ion transmembrane transporter activity 7/555 450/18639 0.0155555555555556 0.522414414414414 0.981916087140307 0.995522314675739 GO:0140101 catalytic activity, acting on a tRNA 1/555 139/18639 0.00719424460431655 0.24160995527902 0.98526671461387 0.997767215029963 GO:0015293 symporter activity 1/555 146/18639 0.00684931506849315 0.230025916327286 0.988096176178295 0.998231642202337 GO:0015085 calcium ion transmembrane transporter activity 1/555 147/18639 0.00680272108843537 0.2284611141754 0.98845342606858 0.998231642202337 GO:0008509 monoatomic anion transmembrane transporter activity 1/555 149/18639 0.00671140939597315 0.225394522038817 0.989136137489787 0.998231642202337 GO:0015103 inorganic anion transmembrane transporter activity 1/555 165/18639 0.00606060606060606 0.203538083538084 0.993329958931439 0.999505406634956 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 1/555 167/18639 0.00598802395209581 0.201100501699304 0.993724715209295 0.999505406634956 GO:0045182 translation regulator activity 4/555 356/18639 0.0112359550561798 0.377345885211054 0.994248267128639 0.999505406634956 GO:0022836 gated channel activity 3/555 318/18639 0.00943396226415094 0.316828148903621 0.996309117059745 0.999505406634956 GO:0005216 monoatomic ion channel activity 5/555 448/18639 0.0111607142857143 0.374819015444015 0.997576179579095 0.999505406634956 GO:0008168 methyltransferase activity 1/555 204/18639 0.00490196078431373 0.164626391096979 0.997972557313283 0.999505406634956 GO:0016741 transferase activity, transferring one-carbon groups 1/555 215/18639 0.00465116279069767 0.156203645505971 0.998551640242639 0.999505406634956 GO:0030371 translation repressor activity 2/555 329/18639 0.0060790273556231 0.204156740326953 0.999505406634956 0.999505406634956