category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	29/665	137/9376	2.98451237583009	LMNA/CTSL/PMAIP1/TUBA1C/CTSD/MCL1/CASP7/PIK3R3/NOL3/TNFRSF10B/ATF4/CTSK/SEPTIN4/ACTG1/JUN/BCL2L11/SPTAN1/GADD45G/TNFSF10/BAX/PARP1/GADD45A/TNFRSF1A/ATM/TNFRSF10A/RIPK1/CTSF/CTSZ/PIK3R2	6.46493355410678
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	37/665	205/9376	2.54474234366404	HLA-G/HLA-A/CDKN1A/PMAIP1/SCIN/H2BC5/EGR2/H2BC4/CHD4/CDKN2A/H2BC15/PIK3R3/ATF4/JUN/IRF7/EIF2AK2/HLA-E/H2BC11/NFKB2/CCND1/CDKN2B/ACTN1/BAX/H2BC6/H2BC18/H2BC8/GTF2B/RBPJ/H4C8/CCNE1/IRF9/REL/JAK1/DDX3X/STAT3/PKM/PIK3R2	6.1785574489043
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/665	110/9376	3.20437457279563	FLT1/SERPINE1/GAPDH/HMOX1/CDKN1A/EPAS1/PRKCA/EGLN3/PIK3R3/PRKCB/SLC2A1/INSR/PRKCG/ANGPT1/HK2/PFKFB3/CAMK2D/PDK1/LDHC/MKNK2/STAT3/PLCG2/ALDOA/ENO1/PIK3R2	6.42536852398746
NA	NA	hsa04517	IgSF CAM signaling	46/665	299/9376	2.16911509543089	CASK/APP/PTK2/CABLES1/PLXNA1/MAGI1/TUBB4B/TUBA1C/FGFR1/EPB41L1/TUBB2A/VAV3/PRKCA/EZR/PMP22/PIK3R3/PRKCB/ACTG1/BAIAP2/PTPRF/PTPRD/MYLK/TUBB6/PRKCG/SPTAN1/MTSS2/KIRREL1/ITGA5/AFDN/F11R/ACTN1/CDH1/ITGAL/WASL/TUBB8/VCL/PARD6G/VAV2/NECTIN2/PLCG2/MYL6B/MAPK13/CNTNAP2/SPTBN4/PIK3R2/SPTBN1	5.67654583000173
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	23/665	116/9376	2.79554057557687	PTK2/VAV3/PRKCA/EZR/PIK3R3/PRKCB/ACTG1/NCF2/PRKCG/CD99/TXK/AFDN/F11R/ACTN1/ITGAL/MMP2/OCLN/VCL/VAV2/PLCG2/MAPK13/CLDN19/PIK3R2	5.37627133497577
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	16/665	73/9376	3.09024616335359	CDKN1A/PRKCA/CDKN2A/PIK3R3/PRKCB/PRKCG/GADD45G/CCND1/FHIT/BAX/GADD45A/FOXO3/STAT3/PLCG2/PIK3R2/RASSF1	4.95347309586435
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	31/665	204/9376	2.14253280259472	FN1/TIMP3/IGF2/CDKN1A/COL1A2/CTSL/PTK2/FGFR1/WNT5B/TGFB2/VAV3/PRKCA/EZR/TWIST1/PIK3R3/PRKCB/ACTG1/PRKCG/HSPG2/CCND1/ITGA5/SLC9A1/CAMK2D/SDC4/MMP2/STAT3/VAV2/PLCG2/PPP1R12B/MAPK13/PIK3R2	4.55841847808712
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	30/665	195/9376	2.16911509543089	H2AC6/H2BC5/H3-7/H3C12/PRKCA/H2BC4/H2BC15/PIK3R3/PRKCB/ACTG1/NCF2/PRKCG/H2BC11/AZU1/H2BC6/SIGLEC9/H2BC18/H2BC8/ITGAL/SLC25A4/ATG7/H4C8/H2AC8/H2AZ2/H2AX/CASP4/PLCG2/H2AC16/MAPK13/PIK3R2	4.55818590720688
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/665	76/9376	2.96826276216858	CDKN1A/SHC2/PRKCA/CDKN2A/PIK3R3/PRKCB/CALM3/PDGFA/PRKCG/GADD45G/CCND1/BAX/GADD45A/CAMK2D/PLCG2/PIK3R2	4.76004273664493
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	30/665	200/9376	2.11488721804511	GAPDH/TUBB4B/TUBA1C/TUBB2A/EZR/CASP7/TNFRSF10B/CYFIP1/ACTG1/MYO1D/BAIAP2/JUN/IL18/MYO1E/TUBB6/TNFSF10/CYTH1/BAX/TNFRSF1A/TNFRSF10A/CYTH3/MYO5B/WASL/TUBB8/OCLN/CASP4/RIPK1/MAPK13/NCL/CLDN19	4.40333457904468
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/665	101/9376	2.65233380480905	FN1/SERPINE1/EGR1/COL1A2/TGFB2/PRKCA/STAT1/PIK3R3/PRKCB/PRKCE/JUN/CCND1/BAX/COL4A1/MMP2/STAT3/PLCG2/MAPK13/PIK3R2	4.61279304080413
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	27/665	173/9376	2.20046068929549	MX1/MX2/RSAD2/OAS3/OAS2/OAS1/PRKCA/STAT1/PIK3R3/PRKCB/TNFRSF10B/IFIH1/ACTG1/IL18/IRF7/EIF2AK2/TNFSF10/BAX/TNFRSF1A/PML/SLC25A4/TNFRSF10A/IRF9/JAK1/ADAR/TLR3/PIK3R2	4.40320329895305
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	25/665	156/9376	2.25949489107384	MX1/MX2/RSAD2/CDKN1A/IFIT1/OAS3/OAS2/OAS1/STAT1/PIK3R3/SCARB1/IRF7/EIF2AK2/CCND1/BAX/TNFRSF1A/PPP2CB/OCLN/IRF9/JAK1/STAT3/RIPK1/TLR3/CLDN19/PIK3R2	4.3828408703593
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	35/665	253/9376	1.95048887039734	PTK2/H3-7/H3C12/GSK3A/PIK3R3/TLN1/ACTG1/PRKCE/JUN/IL18/CGAS/BNIP3/UBE2D1/ITGA5/SQSTM1/CYTH1/ACTN1/BAX/PPID/NOD1/HK2/TNFRSF1A/ATM/CYTH3/DOCK1/WASL/FOXO3/VCL/CASP4/RIPK1/PLCG2/MAPK13/PIK3R2/CAST/NLRC4	4.23448806431045
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	23/665	142/9376	2.28368103356984	ACP5/TGFB2/STAT1/PIK3R3/CTSK/LILRB3/JUN/NCF2/CSF1R/NFKB2/SQSTM1/TNFRSF1A/TEC1/IRF9/LILRA6/FHL2/NFATC2/FOSL2/JAK1/ATP2A2/PLCG2/MAPK13/PIK3R2	4.2586192766786
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/665	75/9376	2.81984962406015	SERPINE1/CDKN1A/PMAIP1/CDKN2A/TNFRSF10B/GADD45G/CCND1/BAX/SHISA5/GADD45A/ATM/TNFRSF10A/CCNE1/PPM1D/GTSE1	4.37183504188063
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/665	203/9376	2.01417830290011	SPP1/FN1/FLT1/COL1A2/PTK2/SHC2/VAV3/PRKCA/LAMA3/PIK3R3/TLN1/PRKCB/EMP2/ACTG1/JUN/MYLK/PDGFA/PRKCG/CCND1/ITGA5/ACTN1/FLNB/COL4A1/DOCK1/VCL/VAV2/PPP1R12B/LAMC1/PIK3R2	4.03616666581367
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/665	93/9376	2.57728191446358	FN1/CDKN1A/BIRC7/PTK2/LAMA3/PIK3R3/GADD45G/CCND1/FHIT/CDKN2B/BAX/GADD45A/COL4A1/CCNE1/LAMC1/CKS2/PIK3R2	4.22346672249259
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/665	205/9376	1.99452778287181	HLA-G/HLA-A/ISG15/CDKN1A/OAS3/OAS2/OAS1/STAT1/PIK3R3/JUN/IRF7/EIF2AK2/HLA-E/BCL2L11/GADD45G/NFKB2/CCND1/BAX/GADD45A/ITGAL/RBPJ/CCNE1/IRF9/JAK1/STAT3/RIPK1/PLCG2/MAPK13/PIK3R2	3.97784592764509
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	24/665	157/9376	2.15529907571476	SERPINE1/HLA-G/HLA-A/CDKN1A/TGFB2/CDKN2A/PIK3R3/CALM3/HLA-E/GADD45G/CCND1/SQSTM1/CDKN2B/PPID/GADD45A/SLC25A4/ATM/CCNE1/FOXO3/HIPK4/NFATC2/HUS1/MAPK13/PIK3R2	4.03333967634151
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	25/665	168/9376	2.09810239885428	FTL/H2AC6/STAT1/PYGL/TNFRSF10B/EIF2AK2/TNFSF10/SQSTM1/BAX/PPID/PARP1/TNFRSF1A/SLC25A4/CAMK2D/TNFRSF10A/H2AC8/IRF9/H2AZ2/H2AX/JAK1/STAT3/RIPK1/H2AC16/PYGM/TLR3	3.96805131484511
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	26/665	180/9376	2.03655806182122	HLA-G/HLA-A/SRSF7/OAS3/OAS2/OAS1/SRSF2/STAT1/PIK3R3/IFIH1/IRF7/EIF2AK2/HLA-E/BST2/SRSF3/CGAS/ITGA5/BAX/TNFRSF1A/PML/IRF9/JAK1/NECTIN2/TLR3/POU2F1/PIK3R2	3.87965277968878
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	21/665	133/9376	2.22619707162643	CDKN1A/TGFB2/PIK3R3/PLK2/BCL2L11/INSR/GADD45G/TNFSF10/BNIP3/CCND1/IRS2/CDKN2B/GADD45A/ATM/FOXO3/PRKAG2/TPTEP2-CSNK1E/STAT3/MAPK13/PLK3/PIK3R2	3.9349758612923
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/665	109/9376	2.32831620335242	PIK3R3/PYGL/PRKCB/SLC2A1/PRKCE/PTPRF/INSR/RPS6KA2/PPP1R3C/IRS2/GYS1/TNFRSF1A/PPP1R3B/TBC1D4/PRKAG2/STAT3/PYGM/PIK3R2	3.85396345196924
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/665	103/9376	2.32706036937003	FN1/HSPB1/COL1A2/PTK2/PRDX1/TGFB2/PRKCA/LAMA3/C9/PIK3R3/PRKCB/PRKCG/ACTN1/COL4A1/VCL/LAMC1/PIK3R2	3.74163669613927
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/665	78/9376	2.5306342780027	FN1/PTK2/DNM1/SHC2/PIK3R3/ACTG1/CLTC/ARHGAP10/ITGA5/CDH1/DOCK1/WASL/VCL/PIK3R2	3.75047624783469
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	39/665	333/9376	1.65126329336856	SPP1/FN1/MX1/MX2/HLA-G/HLA-A/ISG15/IRF1/CDKN1A/COL1A2/PTK2/MAGI1/WNT5B/LAMA3/CHD4/STAT1/PIK3R3/DLG2/EIF2AK2/HLA-E/CCND1/ITGA5/BAX/TNFRSF1A/PPP2CB/ATM/COL4A1/RBPJ/CCNE1/IRF9/JAK1/PALS1/PARD6G/OASL/PKM/LAMC1/TLR3/CSNK1A1/PIK3R2	3.34337358099465
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/665	136/9376	2.0734188412207	MX1/MX2/OAS3/OAS2/OAS1/STAT1/PIK3R3/IL2RA/IFIH1/JUN/IRF7/EIF2AK2/CCND1/BAX/CCNE1/IRF9/JAK1/STAT3/ADAR/PIK3R2	3.48389563432379
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	30/665	238/9376	1.77721614961774	MX1/MX2/ISG15/OAS3/OAS2/OAS1/PRKCA/C9/STAT1/PIK3R3/PRKCB/IFIH1/CFD/JUN/EIF2AK2/RPS9/PRKCG/RPS12/CGAS/TNFRSF1A/IRF9/RPL36A-HNRNPH2/JAK1/STAT3/ADAR/PLCG2/RPS10/TLR3/MAPK13/PIK3R2	3.35557671274503
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	29/665	232/9376	1.76240601503759	FN1/ENAH/PTK2/SCIN/FGFR1/RGCC/VAV3/EZR/C9/PIK3R3/CYFIP1/ACTG1/BAIAP2/MYLK/PDGFA/ITGA5/GNG12/ACTN1/LIMK2/ITGAL/CYRIA/SLC9A1/DOCK1/WASL/VCL/IQGAP2/VAV2/PPP1R12B/PIK3R2	3.24881253220194
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	23/665	170/9376	1.90754533392304	IGF2/HMOX1/CDKN1A/WNT5B/SHC2/TGFB2/PRKCA/CDKN2A/PIK3R3/PRKCB/ACTG1/PRKCG/GADD45G/CCND1/BAX/GADD45A/TXNRD1/SMARCA4/GSTO1/GSTO2/PLCG2/CSNK1A1/PIK3R2	3.29928443083867
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/665	212/9376	1.79565895871755	FLT1/ENAH/MAGI1/FGFR1/VAV3/PRKCA/EFNA2/PIK3R3/TLN1/PRKCB/ACTG1/RASGRP3/CALM3/INSR/PDGFA/PRKCG/CSF1R/AFDN/ANGPT1/CDH1/ITGAL/RGS14/EFNA1/PARD6G/VAV2/MAPK13/PIK3R2	3.23753745353724
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	22/665	163/9376	1.90296600396697	CDKN1A/TGFB2/PRKCA/EGR2/STAT1/PIK3R3/PRKCB/ATF4/IFIH1/JUN/IRF7/PRKCG/HSPG2/BAX/CCNE1/NFATC2/JAK1/DDX3X/STAT3/TLR3/MAPK13/PIK3R2	3.21312129433114
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	26/665	205/9376	1.78819732257473	GAPDH/MT-ND1/COL1A2/CTSD/TGFB2/PRKCA/PIK3R3/PRKCB/SLC2A1/NCF2/INSR/MT-ND2/PRKCG/PARP1/NDUFA7/GYS1/SLC25A4/MT-ND5/CAMK2D/MT-ND4/MMP2/TBC1D4/ATP2A2/MT-CO1/MAPK13/PIK3R2	3.15257910717288
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	30/665	248/9376	1.7055542081009	GAPDH/AHNAK/TUBB4B/TUBA1C/TUBB2A/CASP7/TNFRSF10B/CYFIP1/ACTG1/JUN/IL18/TUBB6/TNFSF10/ANXA2/CYTH1/BAX/NOD1/TNFRSF1A/TNFRSF10A/CYTH3/WASL/TUBB8/TXN/CASP4/PLEKHM2/EXOC4/PLEKHM1/RIPK1/MAPK13/NLRC4	3.11122102580401
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/665	77/9376	2.38039253979104	CDKN1A/TGFB2/CDKN2A/STAT1/PIK3R3/GADD45G/CCND1/BAX/GADD45A/RALBP1/JAK1/STAT3/PIK3R2	3.36041021516794
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/665	216/9376	1.76240601503759	PTK2/VAV3/PRKCA/CASP7/PIK3R3/TNFRSF10B/ATF4/JUN/IL18/IRF7/CALM3/NCF2/ABCA1/TNFSF10/BAX/TNFRSF1A/MIB1/TANK/CAMK2D/TNFRSF10A/NFATC2/STAT3/HSPA2/VAV2/MAPK13/POU2F1/PIK3R2	3.13204437653418
NA	NA	hsa04518	Integrin signaling	21/665	154/9376	1.92262474367738	SPP1/FN1/FLT1/COL1A2/PTK2/LAMA3/PIK3R3/TLN1/ACTG1/PDGFA/CCND1/ITGA5/ACTN1/FLNB/CDH1/ITGAL/FBN1/COL4A1/VCL/LAMC1/PIK3R2	3.18959361399803
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/665	60/9376	2.58486215538847	HSPB1/PTK2/SHC2/PRKCA/PIK3R3/PRKCB/PRKCG/NFATC2/PLCG2/MAPK13/PIK3R2	3.40263084307195
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/665	98/9376	2.15804818167869	SCIN/VAV3/PRKCA/ASAP2/PIK3R3/PRKCB/PRKCE/PRKCG/PLPP3/LIMK2/DOCK1/MARCKSL1/VAV2/PLCG2/PIK3R2	3.18401376601421
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/665	80/9376	2.29112781954887	SHC2/PRKCA/PIK3R3/PRKCB/BCL2L11/PDGFA/PRKCG/BAX/FOXO3/JAK1/STAT3/PLCG2/PIK3R2	3.20426649595625
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	34/665	300/9376	1.59791478696742	FLT1/IGF2/HSPB1/FGFR1/TGFB2/PRKCA/EFNA2/PRKCB/ATF4/DUSP4/RASGRP3/JUN/CACNB4/INSR/PDGFA/PRKCG/GADD45G/DUSP2/RPS6KA2/CSF1R/NFKB2/GNG12/ANGPT1/CACNA2D3/GADD45A/TNFRSF1A/MAP3K9/ARRB1/MAP3K13/EFNA1/MKNK2/DUSP9/MAP3K11/MAPK13	2.90813880694981
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	27/665	224/9376	1.69946294307197	HLA-G/HLA-A/EGR1/CDKN1A/TGFB2/EGR2/CDKN2A/PIK3R3/IL2RA/TLN1/ATF4/SLC2A1/JUN/HLA-E/NFKB2/CCND1/CDKN2B/BAX/TNFRSF1A/ITGAL/SLC25A4/ATM/CCNE1/NFATC2/JAK1/PIK3R2/CRTC1	2.92747482032084
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	17/665	122/9376	1.96464932823863	SLC16A10/RCAN1/DIO2/PRKCA/STAT1/PIK3R3/PRKCB/ACTG1/SLC2A1/ATP1A1/PRKCG/CCND1/SLC9A1/TBC1D4/ATP2A2/PLCG2/PIK3R2	2.9631053180556
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	23/665	184/9376	1.76240601503759	SEMA4A/ENAH/PTK2/PLXNA1/RGMA/WNT5B/PRKCA/EPHB3/EFNA2/PIK3R3/EPHB2/SEMA4B/SEMA6B/LIMK2/SEMA3B/CAMK2D/EFNA1/NFATC2/EFNB1/PARD6G/PLCG2/RGS3/PIK3R2	2.88570991519212
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/665	133/9376	1.90816891853694	HLA-G/HLA-A/ULBP2/SHC2/VAV3/PRKCA/PIK3R3/PRKCB/TNFRSF10B/HLA-E/PRKCG/TNFSF10/ITGAL/TNFRSF10A/NFATC2/VAV2/PLCG2/PIK3R2	2.91439512873631
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/665	196/9376	1.72643854534295	HLA-G/HLA-A/CDKN1A/RCAN1/STAT1/PIK3R3/JUN/IRF7/CALM3/EIF2AK2/HLA-E/CCND1/GNG12/BAX/TNFRSF1A/IRF9/NFATC2/JAK1/STAT3/GNB5/PLCG2/TLR3/MAPK13/PIK3R2	2.8396710189507
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/665	32/9376	3.08421052631579	BIRC7/PMAIP1/CASP7/SEPTIN4/BCL2L11/BAX/TNFRSF1A	3.26296648650751
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/665	187/9376	1.73413212174822	ANTXR1/TXNIP/OAS3/OAS2/GBP2/CARD18/OAS1/STAT1/JUN/IL18/IRF7/NOD1/TRIP6/TANK/IRF9/TXN/PSTPIP1/JAK1/CASP4/RIPK1/GBP3/MAPK13/NLRC4	2.80171114946763
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/665	233/9376	1.63381845170867	FN1/LMNA/COL1A2/INF2/TPM1/COL27A1/BGN/TLN1/ACTG1/ATP1A1/SPTAN1/HSPG2/DSP/ITGA5/FBN1/COL4A1/SDC4/PDLIM5/VCL/FHL2/SUN1/AGRN/SYNE2/ENO1/SPTBN4/TPM2/SPTBN1	2.70682969873591
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/665	138/9376	1.83903236351749	SHC2/PIK3R3/PYGL/PTPRF/CALM3/INSR/PPP1R3C/IRS2/PHKB/GYS1/HK2/PPP1R3B/PRKAG2/PDE3B/MKNK2/PYGM/PHKA1/PIK3R2	2.74341640425983
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	38/665	362/9376	1.48003157063931	SPP1/FN1/CSH1/FLT1/IGF2/CDKN1A/COL1A2/PTK2/MAGI1/FGFR1/DDIT4/IL7/MCL1/PRKCA/EFNA2/LAMA3/PIK3R3/IL2RA/ATF4/BCL2L11/INSR/PDGFA/CSF1R/CCND1/ITGA5/GNG12/ANGPT1/GYS1/PPP2CB/COL4A1/CCNE1/FOXO3/EFNA1/MYB/JAK1/GNB5/LAMC1/PIK3R2	2.57352127762339
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/665	35/9376	2.81984962406015	TPI1/ENOSF1/HK2/PFKFB3/HSD17B14/PFKFB4/ALDOA	2.98013057651084
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/665	142/9376	1.7872286349677	HMOX1/CTSL/PTK2/PIK3R3/ACTG1/JUN/CALM3/NCF2/PDGFA/SQSTM1/TNFRSF1A/SDC4/MMP2/TXN/GSTO1/GSTO2/MAPK13/PIK3R2	2.61163556394045
Human Diseases	Substance dependence	hsa05032	Morphine addiction	13/665	91/9376	2.01417830290011	GRK3/PDE4C/GABRB2/PDE1B/PRKCA/PRKCB/GABRA3/PRKCG/GNG12/PDE4D/ARRB1/PDE3B/GNB5	2.68600311022027
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	19/665	154/9376	1.73951762523191	RYR3/CDKN1A/RCAN1/PRKCA/PRKCB/ACTG1/JUN/CALM3/CACNB4/MYLK/PRKCG/CCND1/CACNA2D3/CAMK2D/PRKAG2/NFATC2/PPP1R12B/MYL6B/KCNJ2	2.55657645325791
Human Diseases	Cancer: specific types	hsa05218	Melanoma	11/665	73/9376	2.12454423730559	CDKN1A/FGFR1/CDKN2A/PIK3R3/PDGFA/GADD45G/CCND1/BAX/CDH1/GADD45A/PIK3R2	2.66494909655301
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/665	37/9376	2.6674253200569	HBA2/HBA1/PRKCA/APOL1/PRKCB/IL18/PRKCG	2.80775701089226
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/665	37/9376	2.6674253200569	CDKN1A/GADD45G/CCND1/BAX/CDH1/GADD45A/PAX8	2.80775701089226
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/665	115/9376	1.83903236351749	EGR1/CDKN1A/PDE4C/FGFR1/PRKCA/MMP15/PRKCB/ATF4/GATA3/PRKCG/GCM1/PDE4D/MAFB/ARRB1/WNK2	2.50127328719095
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/665	38/9376	2.59722991689751	PRKCA/PIK3R3/PRKCB/ATP1A1/INSR/PRKCG/PIK3R2	2.72580481048432
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	24/665	214/9376	1.58122408825803	HLA-G/HLA-A/PTK2/PRKCA/PIK3R3/PRKCB/JUN/CALM3/HLA-E/BST2/PRKCG/CGAS/GNG12/BAX/LIMK2/TNFRSF1A/ATM/NFATC2/APOBEC3D/GNB5/RIPK1/PLCG2/MAPK13/PIK3R2	2.37639046877926
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/665	76/9376	2.0406806489909	PRKCA/EZR/PRKCB/ACTG1/CALM3/ATP1A1/MYLK/PRKCG/SLC9A1/CAMK2D/KCNJ2	2.51678000499192
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/665	138/9376	1.73686389887763	FN1/PTK2/VAV3/PIK3R3/ACTG1/BAIAP2/JUN/IL18/RPS6KA2/ITGA5/DOCK1/WASL/NFATC2/VAV2/MAPK13/PIK3R2/NLRC4	2.40935224406943
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/665	48/9376	2.34987468671679	HIBCH/IL4I1/ACADS/ABAT/AUH/HIBADH/HMGCS1/BCAT2	2.59049201145827
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	11/665	77/9376	2.01417830290011	CDKN1A/SHC2/TGFB2/CDKN2A/PIK3R3/GADD45G/CCND1/BAX/GADD45A/BCR/PIK3R2	2.46890288872694
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/665	87/9376	1.94472387866217	CDKN1A/PMAIP1/TGFB2/PIK3R3/JUN/BCL2L11/GADD45G/CCND1/BAX/GADD45A/PIK3R2/MSH3	2.44592137001909
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/665	59/9376	2.15073276411367	CDKN1A/PIK3R3/GADD45G/CCND1/BAX/CDH1/GADD45A/FOXO3/PIK3R2	2.44976762399527
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/665	41/9376	2.40718870346598	CDKN1A/TYMP/CDKN2A/CCND1/CDH1/MMP2/RASSF1	2.49487942390448
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/665	143/9376	1.67613439192387	H2AC6/H2BC5/H3-7/H3C12/H2BC4/C9/H2BC15/H2BC11/ACTN1/H2BC6/H2BC18/H2BC8/H4C8/H2AC8/H2AZ2/H2AX/H2AC16	2.2510859742643
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/665	91/9376	1.85924151036933	VAV3/PIK3R3/PRKCB/RASGRP3/LILRB3/JUN/DAPP1/LILRA6/NFATC2/VAV2/PLCG2/PIK3R2	2.27566036729707
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/665	71/9376	1.98580959440856	FGFR1/PIK3R3/SLC2A1/SLC1A5/HK2/PDK1/LDHC/GLS/PKM/PIK3R2	2.30370295945291
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/665	52/9376	2.16911509543089	PLTP/ANGPTL4/CYP27A1/SCARB1/ABCA1/APOE/NPC1/APOC2	2.33571721404783
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/665	72/9376	1.95822890559733	ISG15/IFIH1/IRF7/DHX58/TANK/ZNFX1/DDX3X/ADAR/RIPK1/MAPK13	2.25508605213365
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/665	238/9376	1.48101345801478	FLT1/IGF2/FGFR1/SHC2/PRKCA/RALGAPA2/EFNA2/PIK3R3/PRKCB/RASGRP3/CALM3/INSR/PDGFA/PRKCG/CSF1R/AFDN/GNG12/ANGPT1/RALBP1/EFNA1/REL/GNB5/PLCG2/PIK3R2/RASSF1	2.07674217658141
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	24/665	227/9376	1.49066940478951	HLA-G/HLA-A/CDKN1A/PTK2/PRKCA/CDKN2A/PIK3R3/PRKCB/ATF4/CALM3/HLA-E/PRKCG/CGAS/CCND1/GNG12/BAX/TNFRSF1A/NFATC2/JAK1/STAT3/GNB5/RIPK1/MAPK13/PIK3R2	2.06765248449091
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/665	53/9376	2.12818839551709	ATP2B4/DNM1/PRKCA/PRKCB/CLTC/ATP1A1/PRKCG/AP2M1	2.27564322771629
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/665	170/9376	1.57579831932773	MAGI1/TUBA1C/EZR/ACTG1/PRKCE/DLG2/JUN/RAB13/CCND1/AFDN/F11R/ACTN1/PPP2CB/PRKAG2/OCLN/PALS1/PARD6G/MYL6B/CLDN19	2.09325348194909
Cellular Processes	Cell motility	hsa04814	Motor proteins	21/665	194/9376	1.52620727075421	TUBB4B/TUBA1C/TUBB2A/TPM1/KIF26A/ACTG1/MYO1D/KIFC3/MYO1E/TUBB6/MYO18B/KIF13A/STARD9/MYO7A/KIF21A/MYO5B/TUBB8/MYL6B/DYNLT5/KIF16B/TPM2	2.0462162029062
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/665	105/9376	1.74562119584676	IRF1/EGR2/STAT1/PIK3R3/JUN/CALM3/NFKB2/IRF9/NFATC2/PLCG2/MAPK13/PLK3/PIK3R2	2.12281456252736
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/665	75/9376	1.87989974937343	CDKN1A/PMAIP1/CDKN2A/PIK3R3/BAX/ATM/GSTO1/GSTO2/PIK3R2/MSH3	2.11378814314914
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/665	27/9376	2.61097187412977	GAD1/ACSM5/ACADS/ABAT/HMGCS1	2.31605951081358
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/665	107/9376	1.71299276227953	PYGL/ATF4/SLC2A1/CALM3/PHKB/GYS1/CAMK2D/PRKAG2/PDE3B/LDHC/PKM/PYGM/PHKA1	2.04938249829583
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/665	86/9376	1.80339220143382	CDKN1A/PTK2/SHC2/PRKCA/PIK3R3/PRKCB/JUN/PRKCG/CAMK2D/PLCG2/PIK3R2	2.06790905209857
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/665	98/9376	1.72643854534295	PRKCA/PIK3R3/PRKCB/CALM3/DGKH/PRKCG/CDS1/INPP4A/ITPKB/IMPA1/PLCG2/PIK3R2	1.99731787081814
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/665	98/9376	1.72643854534295	ATP2B4/POMC/PRKCA/SCARB1/PRKCB/ATF4/PRKCE/CALM3/ATP1A1/PRKCG/CYP11A1/CAMK2D	1.99731787081814
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/665	47/9376	2.09988801791713	PIK3R3/PRKCE/INSR/IRS2/HK2/PKM/PIK3R2	2.08853764343377
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/665	99/9376	1.70899977215767	CDKN1A/PTK2/SHC2/CDKN2A/PIK3R3/JUN/DLL1/CCND1/BAX/MMP2/MAPK13/PIK3R2	1.95939668341003
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/665	201/9376	1.47305577376277	FLT1/NUPR1/FUS/CDKN1A/PTK2/CEBPA/H3-7/H3C12/HPGD/PTCRA/PDGFA/GADD45G/CSF1R/BAX/GADD45A/PML/ATM/HHEX/MLF1/REL/PAX8	1.87313808346301
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	19/665	178/9376	1.50497592295345	NOTUM/DKK2/ROR1/WNT5B/PRKCA/SFRP1/LZTS2/PRICKLE2/PRKCB/JUN/PRKCG/CCND1/MCC/TLE3/CAMK2D/PPARD/TPTEP2-CSNK1E/NFATC2/CSNK1A1	1.87930134311778
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	14/665	122/9376	1.61794650560828	CSH1/PTK2/SHC2/PRKCA/STAT1/PIK3R3/PRKCB/ATF4/PRKCG/IRS2/STAT3/PLCG2/MAPK13/PIK3R2	1.89814114149139
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/665	100/9376	1.69190977443609	IL34/TNFRSF10D/IL2RA/TNFRSF10B/IL18/CSF1R/TNFSF10/CCL28/TNFRSF1A/TNFRSF10A/CCL14/ACKR3	1.92190337670027
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/665	191/9376	1.47636105971736	H2AC6/H2BC5/SHC2/H3-7/H3C12/H2BC4/H2BC15/ATF4/CALM3/H2BC11/GNG12/H2BC6/H2BC18/H2BC8/H4C8/H2AC8/H2AZ2/H2AX/GNB5/H2AC16	1.83770505523833
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	31/665	323/9376	1.35317861216509	TIMP3/HMOX1/CDKN1A/CYP1B1/DDIT4/MCL1/TGFB2/PRKCA/TPM1/EZR/EFNA2/CDKN2A/PIK3R3/PRKCB/PRKCE/BCL2L11/PDGFA/PRKCG/CCND1/ITGA5/IRS2/FSCN1/ATM/CCNE1/EFNA1/GLS/STAT3/PLCG2/ABCC1/PIK3R2/RASSF1	1.7846861388007
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	17/665	157/9376	1.52667017863129	CEBPA/CASP7/GSK3A/PIK3R3/ATF4/JUN/BCL2L11/INSR/IRS2/BAX/NDUFA7/TNFRSF1A/PRKAG2/MAP3K11/MT-CO1/MAPK13/PIK3R2	1.83869248445925
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/665	69/9376	1.83903236351749	GRIA4/ARC/PRKCA/PRKCB/ATF4/JUN/CALM3/PRKCG/CAMK2D	1.93268401797786
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/665	70/9376	1.8127604726101	CDKN1A/EPAS1/TGFB2/EGLN3/PIK3R3/SLC2A1/JUN/FLCN/PIK3R2	1.88578650739654
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/665	70/9376	1.8127604726101	HLA-G/HLA-A/CD55/ACTG1/HLA-E/CCND1/ITGAL/EIF4G1/EIF4G2	1.88578650739654
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/665	50/9376	1.97389473684211	AOC1/LAP3/OAT/P4HA1/CNDP2/PYCR1/P4HA2	1.90770742224768
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/665	71/9376	1.7872286349677	IRF1/SHC2/STAT1/PIK3R3/CCND1/FOXO3/STAT3/MAPK13/PIK3R2	1.83964626275444
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/665	93/9376	1.66765300347643	FGFR1/ACTG1/BAIAP2/PTPRF/INSR/AFDN/ACTN1/CDH1/WASL/VCL/NECTIN2	1.78776553290661
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/665	31/9376	2.27407227746786	CNDP2/GAD1/HIBCH/ACADS/ABAT	1.96312391649628
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/665	32/9376	2.20300751879699	HIBCH/ACADS/ACSS1/ABAT/LDHC	1.88338613939828
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/665	23/9376	2.45204315135665	IDI1/HMGCS1/PMVK/DHDDS	1.92632884391039
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/665	250/9376	1.35352781954887	HLA-G/HLA-A/IGF2R/GRK3/DNM1/ASAP2/IQSEC1/IL2RA/CLTC/HLA-E/SNX3/RABEP1/PSD3/CYTH1/ARAP2/PML/CYTH3/WASL/EHD1/RAB11FIP5/ARRB1/WASHC2A/AP2M1/PARD6G	1.56536572648303
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/665	75/9376	1.69190977443609	GAPDH/MAT2A/TPI1/ASL/PYCR1/PKM/ALDOA/ENO1/BCAT2	1.66217876340284
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/665	120/9376	1.52741854636591	MAGED1/SHC2/PIK3R3/ATF4/JUN/CALM3/RPS6KA2/BAX/CAMK2D/FOXO3/PLCG2/MAPK13/PIK3R2	1.6065594515459
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/665	109/9376	1.55221080223495	SPP1/STAT1/PIK3R3/CTSK/JUN/IRF7/IRF9/JAK1/RIPK1/TLR3/MAPK13/PIK3R2	1.60217894220135
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/665	76/9376	1.66964780371983	PLIN2/PLTP/ANGPTL4/CYP27A1/FABP5/PPARD/ME1/HMGCS1/FADS2	1.61947491233072
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	14/665	133/9376	1.48413138108429	SCN1A/GRIA4/PRKCA/GSK3A/PRKCB/ATF4/CALM3/PRKCG/GNG12/PPP2CB/CAMK2D/ARRB1/GNB5/MAPK13	1.55362081866165
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	16/665	157/9376	1.43686605047651	SERPINE1/WNT5B/TGFB2/BMP2/ACTG1/DLG2/LIMD1/CCND1/TEAD1/CDH1/PPP2CB/TPTEP2-CSNK1E/PALS1/PARD6G/TP53BP2/RASSF1	1.5251714570475
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/665	99/9376	1.56658312447786	HTR2B/PRKCA/PIK3R3/PRKCB/PRKCE/CALM3/PRKCG/CAMK2D/PLCG2/MAPK13/PIK3R2	1.56581304899367
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/665	99/9376	1.56658312447786	PRKCA/PIK3R3/PRKCB/JUN/DGKH/PDGFA/PRKCG/PLPP3/CHKA/SLC44A2/PIK3R2	1.56581304899367
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/665	89/9376	1.58418518205626	SPP1/FN1/COL1A2/LAMA3/HSPG2/ITGA5/COL4A1/SDC4/AGRN/LAMC1	1.52992545800732
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/665	89/9376	1.58418518205626	HTR2B/TUBB4B/TUBA1C/TUBB2A/PRKCA/PRKCB/TUBB6/PDGFA/PRKCG/TUBB8	1.52992545800732
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/665	89/9376	1.58418518205626	GABRB2/PRKCA/PRKCB/GABRA3/GAD1/PRKCG/GNG12/ABAT/GLS/GNB5	1.52992545800732
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/665	56/9376	1.76240601503759	GRK3/DHH/CCND1/GLI3/TPTEP2-CSNK1E/ARRB1/CSNK1A1	1.58101075885787
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/665	67/9376	1.68349231287173	GAPDH/TPI1/ACSS1/HK2/LDHC/PKM/ALDOA/ENO1	1.55125064352699
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/665	125/9376	1.46632180451128	CTSD/PRKCA/PIK3R3/PRKCB/PRKCE/PRKCG/SPTLC3/BAX/TNFRSF1A/PPP2CB/MAPK13/ABCC1/PIK3R2	1.45013636311094
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/665	149/9376	1.41938739466115	GRIA4/MT-ND1/GABRB2/PRKCA/PRKCB/GABRA3/MT-ND2/PRKCG/GNG12/MGLL/NDUFA7/MT-ND5/MT-ND4/GNB5/MAPK13	1.42574120365227
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/665	68/9376	1.65873507297656	CEBPA/PIK3R3/CSF1R/CCND1/PML/PPARD/STAT3/PIK3R2	1.50625849822095
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/665	36/9376	1.95822890559733	PYGL/GYS1/HK2/GBE1/PYGM	1.59151059351408
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/665	26/9376	2.16911509543089	SCARB1/TCN2/PLB1/ABCC1	1.64930353806972
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/665	37/9376	1.90530380004064	GAD1/ASL/IL4I1/ABAT/GLS	1.52442994656263
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	12/665	116/9376	1.45854290899663	GAPDH/TPI1/HIBCH/ACADS/OGDH/ACSS1/HK2/GCSH/ME1/PKM/ALDOA/ENO1	1.37298545687443
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/665	128/9376	1.43195488721805	NME4/PDE4C/PDE1B/ADA2/FHIT/HDDC2/PDE6G/ENPP4/PDE4D/PDE3B/AK1/PAPSS1/NUDT2	1.3595084783091
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/665	140/9376	1.40992481203008	SPP1/SERPINE1/RYR3/EGR1/PRKCE/CALM3/MYLK/CCND1/GNG12/CDH1/SLC9A1/PRKAG2/PDE3B/GNB5	1.35017081423858
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/665	105/9376	1.47706408879341	CITED2/OPTN/ATF4/JUN/BNIP3/SQSTM1/FOXO3/USP15/FIS1/FKBP8/MARCHF5	1.35822130673124
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/665	18/9376	2.34987468671679	PRDX1/CD320/TCN2	1.58380109720356
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/665	130/9376	1.40992481203008	COL1A2/SHC2/PRKCA/PIK3R3/ATF4/JUN/GNG12/COL4A1/MMP2/ARRB1/GNB5/MAPK13/PIK3R2	1.30035338273157
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	15/665	155/9376	1.36444336648072	HLA-G/HLA-A/COLEC12/MARCO/CTSL/TUBB4B/TUBA1C/TUBB2A/SCARB1/ACTG1/HLA-E/NCF2/TUBB6/ITGA5/TUBB8	1.26406481140515
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/665	193/9376	1.31495578324048	GRK3/PTK2/SHC2/VAV3/GSK3A/STAT1/PIK3R3/PRKCB/GNG12/CCL28/FOXO3/ARRB1/STAT3/GNB5/VAV2/PLCG2/CCL14/PIK3R2	1.22151387276824
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	15/665	157/9376	1.34706192232173	PTK2/CASP7/SLC16A1/DUSP4/SLC2A1/TIMD4/DUSP2/ABCA1/ANO5/CAMK2D/PPARD/DOCK1/NFATC2/ATP2A2/MAPK13	1.21165042963575
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/665	29/9376	1.94472387866217	LIMD1/TEAD1/TPTEP2-CSNK1E/RASSF1	1.40776519675805
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/665	10/9376	2.81984962406015	SQOR/PAPSS1	1.59081940731211
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/665	63/9376	1.56658312447786	HPGD/CBR3/PTGES/PTGR1/PTGR2/CBR1/PLB1	1.24667015378267
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/665	63/9376	1.56658312447786	CDKN1A/WNT5B/BMP2/GADD45G/GLI3/BAX/GADD45A	1.24667015378267
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	33/665	388/9376	1.19916285559259	GAPDH/DKK2/RYR3/APP/MT-ND1/TUBB4B/TUBA1C/WNT5B/BACE2/TUBB2A/CASP7/PIK3R3/ATF4/CALM3/EIF2AK2/INSR/TUBB6/MT-ND2/APOE/IRS2/PPID/NDUFA7/TNFRSF1A/SLC39A12/SLC25A4/MT-ND5/MT-ND4/TUBB8/TPTEP2-CSNK1E/ATP2A2/MT-CO1/CSNK1A1/PIK3R2	1.1070191392464
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/665	75/9376	1.50391979949875	PRKCA/PRKCB/ATF4/ATP1A1/PRKCG/GPX3/ASGR1/PAX8	1.21056938365654
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/665	87/9376	1.45854290899663	TPM1/ATP1A1/CACNB4/CACNA2D3/SLC9A1/TRDN/ATP2A2/MT-CO1/TPM2	1.18718275838843
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	15/665	160/9376	1.3218045112782	HLA-G/HLA-A/SIGLEC1/PTPRF/HLA-E/PTPRD/CD99/F11R/CDH1/ITGAL/SDC4/OCLN/NECTIN2/CNTNAP2/CLDN19	1.13434024428272
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/665	99/9376	1.42416647679806	LMNA/TGFB2/TPM1/ACTG1/CACNB4/ITGA5/CACNA2D3/PRKAG2/ATP2A2/TPM2	1.17222941457731
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/665	148/9376	1.33371266002845	CDKN1A/FGFR1/WNT5B/SHC2/PIK3R3/JUN/DLL1/GADD45G/NFKB2/CCND1/BAX/GADD45A/CSNK1A1/PIK3R2	1.13060838368184
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/665	88/9376	1.44196855775803	SERPINE2/SERPINE1/CFI/CD55/KLKB1/CFHR1/C9/CFD/TFPI	1.15089064744127
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/665	149/9376	1.32476156835041	DNM1/SHC2/PRKCA/PIK3R3/AGPAT2/DGKH/INSR/PDGFA/PLPP3/CYTH1/AGPAT4/CYTH3/PLCG2/PIK3R2	1.10405309089944
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/665	65/9376	1.51838056680162	SPP1/PRKCA/PIK3R3/PRKCB/PRKCG/ARRB1/PIK3R2	1.15869646283513
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	14/665	150/9376	1.3159298245614	CDKN1A/WNT5B/SHC2/TGFB2/PIK3R3/GADD45G/CCND1/CDKN2B/BAX/CDH1/GADD45A/CCNE1/CSNK1A1/PIK3R2	1.07768536383011
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/665	21/9376	2.01417830290011	CSGALNACT1/CHPF/CHSY3	1.2854776215124
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	20/665	227/9376	1.24222450399126	HMOX1/MT-ND1/PTK2/CYP1B1/EPHX1/PIK3R3/JUN/NCF2/MT-ND2/NDUFA7/SLC25A4/MT-ND5/MT-ND4/FOXO3/GSTO1/GSTO2/CBR1/MT-CO1/MAPK13/PIK3R2	1.0207200461112
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/665	139/9376	1.31863471628712	KRT19/KRT18/CTSD/POMC/SHC2/PIK3R3/ATF4/JUN/CALM3/MMP2/GREB1/FKBP5/PIK3R2	1.04567680366318
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/665	90/9376	1.40992481203008	STAT1/PIK3R3/JUN/NFATC2/JAK1/STAT3/BATF2/MAPK13/PIK3R2	1.07962659752365
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/665	78/9376	1.44607673028726	TGFB2/STAT1/PRKCB/JUN/NCF2/JAK1/MARCKSL1/MAPK13	1.09301105149506
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	22/665	254/9376	1.22119471908117	FLT1/RYR3/HTR2B/ATP2B4/FGFR1/PDE1B/PRKCA/PRKCB/CALM3/MYLK/PDGFA/PRKCG/PHKB/SLC25A4/CAMK2D/ITPKB/MCOLN1/NFATC2/TRDN/ATP2A2/PLCG2/PHKA1	0.987436172377762
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/665	115/9376	1.34862373324616	PRKCA/PIK3R3/PRKCB/ATF4/PRKCG/GNG12/KCNQ4/CAMK2D/GNB5/KCNJ2/PIK3R2	1.03929630031634
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/665	103/9376	1.3688590408059	COL1A2/SLC16A10/COL27A1/SLC7A8/ATP1A1/SLC1A5/COL17A1/SLC36A1/COL4A1/DPP4	1.03999528178002
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/665	67/9376	1.47305577376277	PRKCA/PRKCB/ATF4/CALM3/PRKCG/RPS6KA2/CAMK2D	1.07364495496727
NA	NA	hsa04382	Cornified envelope formation	19/665	217/9376	1.23449637919684	KRT19/KRT7/KRT8/KRT18/S100A13/LAMA3/S100A9/S100A1/PRSS8/S100A4/DSP/S100A11/SPTLC3/COL17A1/PCSK6/PPP2CB/COL4A1/OCLN/CLDN19	0.965615954127566
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/665	154/9376	1.28174982911825	ATP2B4/PRKCA/TPM1/ATF4/CALM3/ATP1A1/CACNB4/CACNA2D3/PPP2CB/SLC9A1/CAMK2D/ATP2A2/MAPK13/TPM2	0.974033551407608
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	39/665	480/9376	1.14556390977444	DKK2/RYR3/APP/FUS/GRIA4/MT-ND1/HIP1/TUBB4B/TUBA1C/WNT5B/TUBB2A/PRKCA/CASP7/OPTN/PRKCB/ATF4/CALM3/TUBB6/MT-ND2/PRKCG/GPX3/SQSTM1/BAX/PPID/NDUFA7/TNFRSF1A/SLC25A4/TANK/MT-ND5/CAMK2D/MT-ND4/TUBB8/TPTEP2-CSNK1E/ATP2A2/HTT/FIG4/MT-CO1/MAPK13/CSNK1A1	0.904564203975343
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/665	117/9376	1.32557033609665	H2AC6/CHD4/ACTG1/CECR2/H2AC8/H2AZ2/H2AX/SMARCA4/MORF4L2/H2AC16/INO80	0.97907998081758
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/665	12/9376	2.34987468671679	ASGR1/NPC1	1.29275381441941
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/665	45/9376	1.56658312447786	ABCA9/ABCG2/ABCA6/ABCA1/ABCC1	1.05261184108184
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/665	93/9376	1.36444336648072	STAT1/IL2RA/JUN/GATA3/DLL1/RBPJ/NFATC2/JAK1/MAPK13	0.975865136377956
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/665	93/9376	1.36444336648072	EGR1/PRKCA/PRKCB/ATF4/JUN/CALM3/CAMK2D/MMP2/MAPK13	0.975865136377956
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/665	93/9376	1.36444336648072	RYR3/ATP2B4/PRKCA/PRKCB/CALM3/ATP1A1/PRKCG/SLC9A1/SLC12A2	0.975865136377956
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/665	69/9376	1.43035850495805	VAV3/PRKCA/PIK3R3/VAV2/PLCG2/MAPK13/PIK3R2	0.991316951167791
NA	NA	hsa04519	Cadherin signaling	33/665	404/9376	1.1516712573513	KRT19/KRT7/ENAH/KRT8/PTK2/KRT18/FGFR1/GABRB2/WNT5B/VAV3/PRICKLE2/GABRA3/CYFIP1/LHFPL2/ACTG1/MYO1D/LIMD1/MYO1E/RERE/DSP/MYO7A/AFDN/ACTN1/TEAD1/CDH1/FMN1/TMC6/VCL/PALS1/VAV2/MAPK13/FAT1/CSNK1A1	0.861017128599297
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/665	95/9376	1.33571824297586	FLT1/CTSL/ACP5/TGFB2/CTSK/JUN/IL18/ANGPT1/ITGAL	0.908660839726849
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	23/665	275/9376	1.17920984278879	RYR3/EGR1/MT-ND1/TUBB4B/TUBA1C/TUBB2A/C9/PIK3R3/ATF4/NCF2/TUBB6/MT-ND2/STIP1/BAX/NDUFA7/SLC25A4/MT-ND5/MT-ND4/TUBB8/LAMC1/MT-CO1/MAPK13/PIK3R2	0.833385812071825
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/665	83/9376	1.35896367424586	CASP7/GSDME/IL18/IRF7/ZDHHC11B/CGAS/ADAR/RIPK1	0.907557256201071
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/665	59/9376	1.43382184274245	TYMP/NME4/CMPK2/HDDC2/NT5C3B/NUDT2	0.9235530073318
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/665	59/9376	1.43382184274245	PIK3R3/INSR/IRS2/MGLL/PDE3B/PIK3R2	0.9235530073318
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	21/665	250/9376	1.18433684210526	IGF2R/CTSL/ACP5/CTSD/SCARB2/CTSK/CLTC/DMXL2/GNPTAB/CLN8/SLC36A1/MCOLN1/AP2M1/AP5Z1/PLEKHM1/FIG4/NPC1/GGA2/TLR3/CTSF/CTSZ	0.816214619624304
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/665	122/9376	1.27124368297794	PIK3R3/INSR/CCND1/IRS2/GYS1/PPP2CB/PFKFB3/FOXO3/PRKAG2/PFKFB4/PIK3R2	0.833176964927187
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/665	97/9376	1.30817766064646	RYR3/GRIA4/PRKCA/PRKCB/CALM3/PRKCG/GNG12/CAMK2D/GNB5	0.842944318627606
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/665	36/9376	1.56658312447786	GALNT3/GCNT1/GALNT1/GALNT10	0.941030936810158
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	19/665	226/9376	1.18533501896334	GRIA4/PDE4C/ATP2B4/POMC/VAV3/PIK3R3/JUN/CALM3/ATP1A1/AFDN/GLI3/CNGA1/SLC9A1/CAMK2D/PDE4D/PDE3B/ATP2A2/VAV2/PIK3R2	0.779226320011097
NA	NA	hsa03272	Virion - Hepatitis viruses	5/665	48/9376	1.468671679198	SCARB1/HSPG2/OCLN/DPP4/CLDN19	0.899409591798546
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/665	48/9376	1.468671679198	PIK3R3/PRKCB/ATP1A1/HK2/PIK3R2	0.899409591798546
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/665	110/9376	1.28174982911825	RGMA/TGFB2/NBL1/BMP2/LTBP1/INHBA/CDKN2B/PPP2CB/FBN1/NOG	0.821251753670583
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/665	86/9376	1.31155796467914	PRKCA/PRKCB/ATF4/SLC2A1/ATP1A1/TRPM4/PRKCG/CAMK2D	0.801941485445792
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/665	62/9376	1.36444336648072	PIK3R3/INSR/IRS2/FOXO3/PRKAG2/PIK3R2	0.795463453995709
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/665	50/9376	1.40992481203008	HBA2/HBA1/TGFB2/IL18/ITGAL	0.802978573443142
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/665	38/9376	1.48413138108429	GALE/HK2/AMDHD2/GALK2	0.826210198985807
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	14/665	166/9376	1.18909321496512	ATP2B4/ATF4/PRKCE/CALM3/ATP1A1/INSR/MYLK/IRS2/CNGA1/SLC25A4/PDE3B/NFATC2/ATP2A2/IRAG1	0.679145189239418
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/665	27/9376	1.56658312447786	HSD17B4/HACD2/FADS2	0.814564335471272
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/665	168/9376	1.1749373433584	CSH1/CDKN1A/IL7/MCL1/STAT1/PIK3R3/IL2RA/PDGFA/CCND1/IRF9/JAK1/IL27RA/STAT3/PIK3R2	0.632145377382888
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/665	90/9376	1.25326649958229	PIK3R3/ATF4/INSR/IRS2/BAX/FOXO3/PRKAG2/PIK3R2	0.66703268791324
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/665	65/9376	1.30146905725853	AGPAT2/DGKH/PLPP3/MBOAT1/MGLL/AGPAT4	0.673850743392892
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/665	78/9376	1.26531713900135	TPI1/PLCH1/INPP4A/ITPKB/IMPA1/PLCG2/FIG4	0.650100185438458
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/665	78/9376	1.26531713900135	DHX36/TOB2/HSPA9/TOB1/EXOSC6/ENO1/ZCCHC7	0.650100185438458
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/665	78/9376	1.26531713900135	IRF1/CASP7/JUN/CALM3/ITGA5/NOD1/MAPK13	0.650100185438458
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/665	104/9376	1.22012724117987	AGPAT2/DGKH/PLPP3/MBOAT1/CDS1/AGPAT4/SELENOI/PLB1/CHKA	0.623686297790516
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/665	28/9376	1.51063372717508	PCBD1/SPR/CBR1	0.74763842549365
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/665	66/9376	1.28174982911825	TGFB2/STAT1/JUN/IL18/GATA3/STAT3	0.634633864419031
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/665	105/9376	1.20850698174006	PRKCB/GADD45G/NFKB2/PARP1/GADD45A/TNFRSF1A/ATM/RIPK1/PLCG2	0.593628050935132
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/665	105/9376	1.20850698174006	LMNA/TGFB2/TPM1/ACTG1/CACNB4/ITGA5/CACNA2D3/ATP2A2/TPM2	0.593628050935132
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/665	79/9376	1.24930046635576	CYP1B1/EPHX1/CBR3/DHDH/GSTO1/GSTO2/CBR1	0.614791246151117
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/665	158/9376	1.16006471875892	WNT5B/DDIT4/PRKCA/PIK3R3/PRKCB/FNIP2/INSR/PRKCG/RPS6KA2/TNFRSF1A/FLCN/RICTOR/PIK3R2	0.560619579673926
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/665	29/9376	1.45854290899663	CALM3/CNGA1/PDE6G	0.683290391071489
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/665	17/9376	1.65873507297656	CYP27A1/HSD17B4	0.75107443229717
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/665	17/9376	1.65873507297656	TXNRD1/PAPSS1	0.75107443229717
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/665	43/9376	1.31155796467914	SCARB1/AGPAT2/PLPP3/ABCA1	0.565750448493632
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/665	56/9376	1.25886143931257	CASP7/IL18/BNIP3/NFKB2/NLRC4	0.536804160164478
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/665	109/9376	1.16415810167621	STAT1/IL2RA/JUN/GATA3/NFATC2/JAK1/IL27RA/STAT3/MAPK13	0.476286687317409
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/665	70/9376	1.20850698174006	POMC/SLC2A1/IRS2/TNFRSF1A/PRKAG2/STAT3	0.483782942347911
NA	NA	hsa04981	Folate transport and metabolism	3/665	31/9376	1.36444336648072	ABCG2/ABCC1/ST20-MTHFS	0.561543879102858
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/665	57/9376	1.23677615090357	HSD17B4/ACADS/HACD2/ACADVL/FADS2	0.495396783207424
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/665	44/9376	1.28174982911825	HLA-G/HLA-A/GAD1/HLA-E	0.517565224896468
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/665	19/9376	1.48413138108429	OGDH/GCSH	0.583625385714596
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/665	85/9376	1.16111455108359	TYMP/NME4/CMPK2/ADA2/HDDC2/AK1/NT5C3B	0.412264037650939
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/665	112/9376	1.13297529538131	BIRC7/TGFB2/LAMA3/STAT1/TNFRSF1A/JAK1/STAT3/LAMC1/MAPK13	0.391149839004032
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/665	86/9376	1.14761321909425	LMNA/ACTG1/CACNB4/DSP/ITGA5/CACNA2D3/ATP2A2	0.379952296561532
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/665	73/9376	1.1588423112576	MX1/MX2/BICD1/BST2/ELL/APOBEC3D	0.376425097241675
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/665	169/9376	1.08455754771544	CTSL/CTSD/DDIT4/OPTN/PIK3R3/BNIP3/SQSTM1/IRS2/PPP2CB/TANK/ATG7/PLEKHM1/PIK3R2	0.3064778653367
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/665	47/9376	1.19993601023836	ACSS1/ME1/LDHC/PKM	0.379651270728034
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/665	102/9376	1.10582338198437	ATP2B4/PRKCA/PRKCB/ATP1A1/PRKCG/SLC9A1/SLC12A2/ATP2A2	0.296900296301618
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	12/665	158/9376	1.07082897116208	CDKN1A/TGFB2/CDKN1C/CDKN2A/GADD45G/CCND1/CDC14B/CDKN2B/GADD45A/PPP2CB/ATM/CCNE1	0.248075330713126
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/665	103/9376	1.09508723264472	SERPINE1/TGFB2/PIK3R3/JUN/TNFRSF1A/PPP2CB/MAPK13/PIK3R2	0.268097734820237
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/665	62/9376	1.13703613873393	PTCRA/DLL1/TLE3/RBPJ/DTX1	0.299106117068798
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	22/665	298/9376	1.04088408941818	CSH1/IL34/TNFRSF10D/IL7/TGFB2/GDF15/IL2RA/TNFRSF10B/BMP2/IL18/INHBA/CSF1R/TNFSF10/CCL28/TNFRSF1A/TNFRSF10A/INHA/TNFSF18/TNFRSF21/IL27RA/CCL14/ACKR3	0.198166311691643
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	27/665	368/9376	1.03445570447859	HNRNPA2B1/FUS/MT-ND1/TUBB4B/SRSF7/TUBA1C/TUBB2A/OPTN/ATF4/ACTG1/TUBB6/MT-ND2/SRSF3/GPX3/SQSTM1/BAX/NDUFA7/NUP210/TNFRSF1A/TANK/MT-ND5/MT-ND4/TUBB8/POM121/FIG4/MT-CO1/MAPK13	0.186308774203238
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/665	22/9376	1.28174982911825	AOC1/CNDP2	0.365543253490859
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/665	119/9376	1.06632968977065	IRF1/CASP7/PIK3R3/ATF4/JUN/TNFRSF1A/RIPK1/MAPK13/PIK3R2	0.201191101744777
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/665	217/9376	1.03957589827102	CYP1B1/PRKCA/EPHX1/PIK3R3/PRKCB/ATF4/JUN/DLL1/PRKCG/RPS6KA2/CCND1/ARRB1/GSTO1/GSTO2/STAT3/PIK3R2	0.162966775437292
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/665	106/9376	1.06409419775855	CDKN1A/FGFR1/PIK3R3/ATF4/PDGFA/CCND1/CCNE1/PIK3R2	0.183355624042904
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/665	134/9376	1.05218269554483	ADM/PRKCA/PRKCB/PRKCE/CALM3/MYLK/PRKCG/PPP1R12B/MYL6B/IRAG1	0.168096387509358
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/665	23/9376	1.22602157567833	ASL/GLS	0.299847756017751
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/665	23/9376	1.22602157567833	ATP1A1/GLS	0.299847756017751
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/665	51/9376	1.10582338198437	PLA2G7/PLPP3/SELENOI/PLB1	0.209365326494254
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/665	51/9376	1.10582338198437	PRKCA/ACTG1/SLC12A2/PLCG2	0.209365326494254
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/665	37/9376	1.14318228002439	GALE/HK2/GALK2	0.241102882233004
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/665	122/9376	1.04010846789104	VAV3/PIK3R3/JUN/PPP2CB/TEC1/NFATC2/VAV2/MAPK13/PIK3R2	0.123200847217717
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/665	52/9376	1.08455754771544	CYP1B1/SCARB1/INSR/CYP11A1	0.168933341591864
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/665	24/9376	1.1749373433584	HS6ST1/HS2ST1	0.237081874688297
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/665	39/9376	1.08455754771544	MAT2A/GCSH/ST20-MTHFS	0.146198682007019
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/665	39/9376	1.08455754771544	HLA-G/HLA-A/HLA-E	0.146198682007019
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/665	268/9376	0.999573560767591	RYR3/MT-ND1/TUBB4B/TUBA1C/TUBB2A/ATF4/CALM3/TUBB6/MT-ND2/BAX/NDUFA7/SLC39A12/SLC25A4/MT-ND5/CAMK2D/MT-ND4/TUBB8/TXN/MT-CO1	-0.00195693090970534
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/665	54/9376	1.04438874965191	MAT2A/IL4I1/LDHC/BCAT2	0.0903811153668152
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/665	83/9376	1.01922275568439	CBX4/UBE2D1/SCMH1/KDM2A/RYBP/PCGF3	0.0486003254847494
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	11/665	155/9376	1.00059180208586	CDKN1A/WNT5B/POMC/CDKN2A/SCARB1/ATF4/CCND1/CDKN2B/CYP11A1/CAMK2D/CCNE1	0.00205265415934292
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/665	26/9376	1.08455754771544	PLB1/FADS2	0.119287710134458
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/665	70/9376	1.00708915145005	CYP1B1/EPHX1/GSTO1/GSTO2/CBR1	0.0164484206650328
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/665	41/9376	1.03165230148542	GRIA4/GABRB2/GABRA3	0.0561180426624329
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/665	71/9376	0.992904797204278	JUN/F11R/NOD1/PLCG2/MAPK13	-0.0165805240394612
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/665	144/9376	0.979114452798663	FGFR1/WNT5B/PIK3R3/INHBA/PCGF3/JAK1/STAT3/DUSP9/MAPK13/PIK3R2	-0.0697817184782583
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/665	115/9376	0.980817260542661	APP/HTR2B/GABRB2/PRKCA/PRKCB/PRKCG/GNG12/GNB5	-0.0571864398396188
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/665	42/9376	1.00708915145005	AOC1/CYP1B1/IL4I1	0.0127217675356314
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/665	42/9376	1.00708915145005	HMOX1/FTL/ATG7	0.0127217675356314
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/665	101/9376	0.977175612298072	WNT5B/POMC/PRKCA/PRKCB/CALM3/PRKCG/CAMK2D	-0.0637184668410487
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/665	116/9376	0.972361939331086	GRIA4/GRK3/PRKCA/PRKCB/PRKCG/GNG12/GLS/GNB5	-0.082754862435154
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/665	28/9376	1.00708915145005	B3GNT2/GCNT2	0.0103794985449266
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/665	59/9376	0.955881228494966	LAP3/GPX3/GSTO1/GSTO2	-0.093923403777178
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/665	44/9376	0.961312371838688	POLE/POLG2/PARP1	-0.0710679081250367
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/665	13/9376	1.08455754771544	POLM	0.0842905713789173
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/665	90/9376	0.939949874686717	ABCG2/EPHX1/SCARB1/SLC2A1/ATP1A1/SLC9A1	-0.158155131307572
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/665	60/9376	0.939949874686717	PRKCA/PRKCB/PRKCG/PPP2CB	-0.128925034790316
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/665	45/9376	0.939949874686717	HLA-G/HLA-A/HLA-E	-0.111562576138253
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/665	61/9376	0.92454086034759	HMOX1/FTL/ATP2B4/ATP1A1	-0.163360777283207
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/665	30/9376	0.939949874686717	ABCG2/ABCC1	-0.0910173341351198
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	12/665	181/9376	0.934756781456403	CTSD/TGFB2/STAT1/IL18/CALM3/BAX/TNFRSF1A/HSPA9/CAMK2D/JAK1/MAPK13/PLK3	-0.244884474426935
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/665	46/9376	0.919516181758745	BLVRB/HMOX1/FTL	-0.151185144573488
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/665	14/9376	1.00708915145005	B3GNT2	0.00733392404804981
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/665	31/9376	0.909628910987145	ACSS1/GCSH	-0.139246139593854
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/665	63/9376	0.895190356844492	PLOD2/PHYKPL/SMYD3/CAMKMT	-0.230615859007443
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/665	79/9376	0.892357475968402	DNM1/CLTC/NAPA/AP2M1/STX3	-0.265453500571472
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/665	15/9376	0.939949874686717	AK1	-0.0643073893175291
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/665	32/9376	0.881203007518797	GALE/HK2	-0.18598438126558
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/665	32/9376	0.881203007518797	PPP2CB/ATG7	-0.18598438126558
Organismal Systems	Immune system	hsa04611	Platelet activation	8/665	126/9376	0.895190356844492	COL1A2/PIK3R3/TLN1/ACTG1/MYLK/PLCG2/MAPK13/PIK3R2	-0.32724883000701
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/665	49/9376	0.863219272671475	GALNT3/GALNT1/GALNT10	-0.265224973304189
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/665	65/9376	0.867646038172354	POMC/SCARB1/ATF4/CYP11A1	-0.295840695491576
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/665	33/9376	0.854499886078833	OGDH/BCAT2	-0.231334061551094
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/665	33/9376	0.854499886078833	USE1/STX3	-0.231334061551094
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/665	16/9376	0.881203007518797	IL4I1	-0.131398366703506
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/665	82/9376	0.859710251237851	HLA-G/HLA-A/CTSL/HLA-E/HSPA2	-0.352528297466153
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/665	144/9376	0.881203007518797	PRKCA/PIK3R3/PRKCB/PRKCG/SLC25A4/GTF2B/RBPJ/ATP2A2/PIK3R2	-0.396918414704333
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/665	34/9376	0.829367536488279	PRKAG2/TPTEP2-CSNK1E	-0.275387131270692
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/665	83/9376	0.84935229640366	PRDX1/HSD17B4/PXMP2/DECR2/PMVK	-0.380878139873412
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/665	17/9376	0.829367536488279	GAD1	-0.19455117227088
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/665	69/9376	0.817347717118884	PDE1B/CALM3/PDE3B/KCNJ2	-0.420733649047311
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/665	36/9376	0.783291562238931	DHDH/FGGY	-0.359928376597692
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/665	54/9376	0.783291562238931	HLA-G/HLA-A/HLA-E	-0.441245821696709
NA	NA	hsa04082	Neuroactive ligand signaling	12/665	199/9376	0.850205916802055	GRIA4/HTR2B/GABRB2/TAC3/POMC/PRKCA/PRKCB/GABRA3/PRKCG/GNG12/GNB5/SLC17A9	-0.590110423039802
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/665	20/9376	0.704962406015038	NPL	-0.364930114169103
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	19/665	308/9376	0.869758812615956	GRIA4/MT-ND1/HIP1/TUBB4B/TUBA1C/TUBB2A/CLTC/TUBB6/MT-ND2/GPX3/BAX/NDUFA7/SLC25A4/MT-ND5/MT-ND4/TUBB8/AP2M1/HTT/MT-CO1	-0.642141005054857
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/665	21/9376	0.671392767633369	BCAT2	-0.416511812830642
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	14/665	235/9376	0.839955207166853	MT-ND1/FGFR1/ACTG1/MT-ND2/RPS6KA2/MGLL/NDUFA7/MT-ND5/MT-ND4/PRKAG2/SMARCA4/KDM3A/MT-CO1/MAPK13	-0.686500849980738
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/665	110/9376	0.76904989747095	PIK3R3/RPS6KA2/PDE3B/STK10/MAPK13/PIK3R2	-0.673179385080584
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/665	144/9376	0.783291562238931	TRA2A/CCND1/TNFRSF1A/FOXO3/PRKAG2/ACADVL/RIPK1/MAPK13	-0.724055110930407
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/665	23/9376	0.613010787839163	LARGE1	-0.51339278792857
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/665	23/9376	0.613010787839163	MSH3	-0.51339278792857
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/665	43/9376	0.65577898233957	ACADS/ACADVL	-0.625062483390147
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/665	44/9376	0.640874914559125	MGAT1/MAN1C1	-0.659701041146542
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/665	99/9376	0.712083238399028	KRT19/CFI/KRT18/CFD/ITGAL	-0.795688757504492
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/665	82/9376	0.687768200990281	TYMP/NME4/GSTO1/GSTO2	-0.784594351981533
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/665	100/9376	0.704962406015038	CD55/IL7/IL2RA/CSF1R/ITGA5	-0.819519782901401
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/665	26/9376	0.542278773857721	HHEX	-0.645720203833175
NA	NA	hsa04081	Hormone signaling	12/665	219/9376	0.772561540838397	CSH1/IGF2/SLC16A10/POMC/DIO2/PIK3R3/INSR/GNG12/IRS2/STAT3/GNB5/PIK3R2	-0.940961401182278
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/665	86/9376	0.65577898233957	SCN9A/PDE1B/GABRA3/PKD1L3	-0.886015270091248
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/665	49/9376	0.575479515114316	ATF4/JUN	-0.823167389660499
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/665	28/9376	0.503544575725027	HACD2	-0.726879428403797
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/665	30/9376	0.469974937343358	OGDH	-0.803353331506474
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/665	30/9376	0.469974937343358	PLB1	-0.803353331506474
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/665	31/9376	0.454814455493573	ALDOA	-0.840036158290566
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/665	31/9376	0.454814455493573	HSD17B14	-0.840036158290566
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/665	31/9376	0.454814455493573	IMMP2L	-0.840036158290566
Human Diseases	Immune disease	hsa05310	Asthma	1/665	32/9376	0.440601503759398	PRG2	-0.875774554820199
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/665	94/9376	0.599968005119181	S100A9/JUN/MAPK6/MAPK13	-1.07696186844219
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/665	55/9376	0.5126999316473	PLPP3/SPTLC3	-1.00140329726039
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/665	56/9376	0.503544575725027	MGAT1/MAN1C1	-1.02950573787561
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/665	36/9376	0.391645781119465	POLE	-1.01040803330162
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/665	138/9376	0.613010787839163	MT-ND1/MT-ND2/NDUFA7/MT-ND5/MT-ND4/MT-CO1	-1.26535351802493
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/665	138/9376	0.613010787839163	CALM3/RPS6KA2/PPP2CB/CAMK2D/CCNE1/MAPK13	-1.26535351802493
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/665	174/9376	0.648241292887391	PPP1R15A/MAN1C1/RRBP1/ATF4/WFS1/UBE2D1/BAX/SIL1	-1.29401949737639
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/665	37/9376	0.381060760008128	IL4I1	-1.04222418209663
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/665	38/9376	0.371032845271072	NNMT	-1.0733844125127
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/665	103/9376	0.547543616322359	FUS/PCF11/ETF1/PPP2CB	-1.27569735909933
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/665	142/9376	0.595742878322567	BIRC7/UBE2S/UBE2D1/PML/RHOBTB2/TRIM32	-1.3411253466311
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/665	41/9376	0.34388410049514	GCSH	-1.16326264795859
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/665	41/9376	0.34388410049514	ATM	-1.16326264795859
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/665	66/9376	0.427249943039417	CYP1B1/CYP11A1	-1.29010400159838
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/665	68/9376	0.41468376824414	ALDH1A1/RDH10	-1.33837954649228
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/665	44/9376	0.320437457279563	GTF2B	-1.24833417416805
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/665	154/9376	0.549321355336393	MAT2A/NME4/CMPK2/SPR/AK1/BCAT2	-1.55803509155288
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/665	73/9376	0.386280770419199	GSTO1/GSTO2	-1.4543941022074
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/665	50/9376	0.281984962406015	CCL28	-1.40647912416593
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/665	63/9376	0.223797589211123	POLE	-1.70790187179755
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/665	108/9376	0.261097187412977	NUP210/POM121	-2.1338733465926
Genetic Information Processing	Transcription	hsa03040	Spliceosome	7/665	243/9376	0.406151180420186	FUS/SRSF7/HNRNPU/SRSF2/TRA2A/SRSF3/RBMX	-2.59140182031521
Genetic Information Processing	Translation	hsa03010	Ribosome	5/665	222/9376	0.317550633340107	RPS9/RPS12/RPL36A-HNRNPH2/MRPL14/RPS10	-2.84317716359369
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/665	183/9376	0.154090143391265	RRP7A/REXO2	-3.19288630590053
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/665	370/9376	0.304848608006503	CSH1/ADM/GRIA4/HTR2B/GABRB2/TAC3/POMC/GABRA3	-3.76943918949961
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/665	449/9376	0.188408660850344	GRK3/PDE1B/CALM3/SLC24A4/CAMK2D/ARRB1	-4.86934180363684