ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0030695 GTPase regulator activity 70/1273 489/18639 0.143149284253579 2.09596190825016 2.78046013042887e-09 1.78096646802675e-06 GO:0060589 nucleoside-triphosphatase regulator activity 70/1273 490/18639 0.142857142857143 2.09168443496802 3.03401442593995e-09 1.78096646802675e-06 GO:0005096 GTPase activator activity 44/1273 271/18639 0.162361623616236 2.37726496667952 6.89884848387324e-08 2.69974937335573e-05 GO:0003725 double-stranded RNA binding 19/1273 75/18639 0.253333333333333 3.70925373134328 4.52030071521884e-07 0.000132670825991673 GO:0045296 cadherin binding 46/1273 334/18639 0.137724550898204 2.01653409598713 4.24199634188493e-06 0.000996020741074582 GO:0003779 actin binding 55/1273 443/18639 0.124153498871332 1.81782958795189 1.21656497897875e-05 0.00238041214220176 GO:0043394 proteoglycan binding 11/1273 37/18639 0.297297297297297 4.35296490520371 2.3611869695402e-05 0.00396004786034313 GO:0016209 antioxidant activity 17/1273 86/18639 0.197674418604651 2.89430753210691 6.06227235089637e-05 0.00889638467494043 GO:0004857 enzyme inhibitor activity 50/1273 416/18639 0.120192307692308 1.75983065442021 6.92871526328458e-05 0.009038124132329 GO:0048306 calcium-dependent protein binding 16/1273 80/18639 0.2 2.92835820895522 8.54831584974411e-05 0.0100357228075996 GO:0030527 structural constituent of chromatin 18/1273 98/18639 0.183673469387755 2.68930855924459 0.000101821727622352 0.0100870600592796 GO:0051020 GTPase binding 40/1273 315/18639 0.126984126984127 1.8592750533049 0.000111021911770091 0.0100870600592796 GO:0035091 phosphatidylinositol binding 37/1273 284/18639 0.130281690140845 1.90755728400252 0.000116894938089433 0.0100870600592796 GO:0048029 monosaccharide binding 15/1273 74/18639 0.202702702702703 2.96793061718435 0.000120288620809126 0.0100870600592796 GO:1901981 phosphatidylinositol phosphate binding 27/1273 185/18639 0.145945945945946 2.13691004437273 0.000148496253821253 0.0105240201045325 GO:0005543 phospholipid binding 56/1273 497/18639 0.112676056338028 1.64977927265083 0.000151919045909601 0.0105240201045325 GO:0042578 phosphoric ester hydrolase activity 44/1273 363/18639 0.121212121212121 1.77476255088195 0.000152392113949789 0.0105240201045325 GO:0005516 calmodulin binding 29/1273 207/18639 0.140096618357488 2.05126541207008 0.000178249300106324 0.011546439723355 GO:0044548 S100 protein binding 6/1273 14/18639 0.428571428571429 6.27505330490405 0.000186867423120736 0.011546439723355 GO:0051015 actin filament binding 29/1273 209/18639 0.138755980861244 2.03163607798329 0.000210787852013108 0.0123326685630826 GO:0005085 guanyl-nucleotide exchange factor activity 31/1273 230/18639 0.134782608695652 1.97345879299156 0.000220668133250079 0.0123326685630826 GO:0031267 small GTPase binding 36/1273 283/18639 0.127208480565371 1.86255999156163 0.000231106225202571 0.0123326685630826 GO:0003714 transcription corepressor activity 28/1273 204/18639 0.137254901960784 2.00965759438104 0.000322312933193833 0.0164519731986765 GO:0019838 growth factor binding 21/1273 136/18639 0.154411764705882 2.26086479367867 0.000359818702055875 0.0176011315088999 GO:0097718 disordered domain specific binding 8/1273 28/18639 0.285714285714286 4.18336886993603 0.000419171848387097 0.0196843100002581 GO:0004713 protein tyrosine kinase activity 21/1273 140/18639 0.15 2.19626865671642 0.000535376141772164 0.02417429194002 GO:0005200 structural constituent of cytoskeleton 18/1273 112/18639 0.160714285714286 2.35314498933902 0.000566880172513635 0.0246487897233706 GO:0003712 transcription coregulator activity 53/1273 495/18639 0.107070707070707 1.56770691994573 0.000764868288049391 0.032069834648928 GO:0098641 cadherin binding involved in cell-cell adhesion 6/1273 18/18639 0.333333333333333 4.88059701492537 0.000911311256954682 0.0368923936436137 GO:0016791 phosphatase activity 33/1273 273/18639 0.120879120879121 1.76988682958832 0.00101318634120443 0.0396493588191335 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 5/1273 13/18639 0.384615384615385 5.63145809414466 0.00119358349697578 0.0452021621112763 GO:0004721 phosphoprotein phosphatase activity 23/1273 175/18639 0.131428571428571 1.92434968017058 0.00189902180569154 0.0696703624963083 GO:0005154 epidermal growth factor receptor binding 8/1273 35/18639 0.228571428571429 3.34669509594883 0.00207116952584002 0.0736834249495814 GO:0010314 phosphatidylinositol-5-phosphate binding 6/1273 21/18639 0.285714285714286 4.18336886993603 0.00223186213163921 0.0770648865454246 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 7/1273 29/18639 0.241379310344828 3.53422542460113 0.0028080530005244 0.0941901206461615 GO:0031720 haptoglobin binding 4/1273 10/18639 0.4 5.85671641791045 0.00325733250289455 0.106225232177728 GO:1902936 phosphatidylinositol bisphosphate binding 16/1273 111/18639 0.144144144144144 2.11052843888665 0.00353519190320305 0.112170683631362 GO:0016776 phosphotransferase activity, phosphate group as acceptor 8/1273 39/18639 0.205128205128205 3.00344431687715 0.00424804813817836 0.128279940024015 GO:0038024 cargo receptor activity 11/1273 65/18639 0.169230769230769 2.47784156142365 0.00426142901272281 0.128279940024015 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/1273 48/18639 0.1875 2.74533582089552 0.00467883251807265 0.134249767786676 GO:0005536 D-glucose binding 4/1273 11/18639 0.363636363636364 5.32428765264586 0.00484387765069005 0.134249767786676 GO:0050786 RAGE receptor binding 4/1273 11/18639 0.363636363636364 5.32428765264586 0.00484387765069005 0.134249767786676 GO:0035401 histone H3Y41 kinase activity 16/1273 115/18639 0.139130434782609 2.03711875405581 0.00503150748093162 0.134249767786676 GO:0140801 histone H2AXY142 kinase activity 16/1273 115/18639 0.139130434782609 2.03711875405581 0.00503150748093162 0.134249767786676 GO:0005201 extracellular matrix structural constituent 21/1273 168/18639 0.125 1.83022388059702 0.00528122353473229 0.135261038218819 GO:0004674 protein serine/threonine kinase activity 44/1273 433/18639 0.10161662817552 1.48784943642067 0.00540108421593027 0.135261038218819 GO:0030246 carbohydrate binding 31/1273 280/18639 0.110714285714286 1.62105543710021 0.00542325390349733 0.135261038218819 GO:0140658 ATP-dependent chromatin remodeler activity 20/1273 158/18639 0.126582278481013 1.85339127149065 0.00555304268948884 0.135261038218819 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 6/1273 25/18639 0.24 3.51402985074627 0.00576069157661068 0.135261038218819 GO:0120020 cholesterol transfer activity 6/1273 25/18639 0.24 3.51402985074627 0.00576069157661068 0.135261038218819 GO:0001786 phosphatidylserine binding 10/1273 59/18639 0.169491525423729 2.4816594991146 0.00622100553074966 0.14163725834434 GO:0004725 protein tyrosine phosphatase activity 14/1273 98/18639 0.142857142857143 2.09168443496802 0.00663982553916889 0.14163725834434 GO:0005178 integrin binding 20/1273 161/18639 0.124223602484472 1.81885603040697 0.00683421075905459 0.14163725834434 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 4/1273 12/18639 0.333333333333333 4.88059701492537 0.00687676637617324 0.14163725834434 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 4/1273 12/18639 0.333333333333333 4.88059701492537 0.00687676637617324 0.14163725834434 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 4/1273 12/18639 0.333333333333333 4.88059701492537 0.00687676637617324 0.14163725834434 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 4/1273 12/18639 0.333333333333333 4.88059701492537 0.00687676637617324 0.14163725834434 GO:0046332 SMAD binding 12/1273 79/18639 0.151898734177215 2.22406952578878 0.00709962156590264 0.141825463138506 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 13/1273 89/18639 0.146067415730337 2.13868857957404 0.00724832009225753 0.141825463138506 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 13/1273 89/18639 0.146067415730337 2.13868857957404 0.00724832009225753 0.141825463138506 GO:0046982 protein heterodimerization activity 38/1273 369/18639 0.102981029810298 1.50782672005825 0.00750801459613228 0.142530646064496 GO:0046624 sphingolipid transporter activity 5/1273 19/18639 0.263157894736842 3.85310290652003 0.00764857811078639 0.142530646064496 GO:0050145 nucleoside monophosphate kinase activity 5/1273 19/18639 0.263157894736842 3.85310290652003 0.00764857811078639 0.142530646064496 GO:0140793 histone H2AXY142 phosphatase activity 13/1273 90/18639 0.144444444444444 2.11492537313433 0.00795715758362897 0.145964109424694 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/1273 28/18639 0.214285714285714 3.13752665245203 0.0102873708465734 0.185805744213494 GO:0019902 phosphatase binding 22/1273 190/18639 0.115789473684211 1.69536527886881 0.0105933521798 0.188433264531594 GO:0140789 histone phosphatase activity 17/1273 136/18639 0.125 1.83022388059702 0.011324943949796 0.197559283181716 GO:0001221 transcription coregulator binding 15/1273 115/18639 0.130434782608696 1.90979883192732 0.011585453126075 0.197559283181716 GO:0030291 protein serine/threonine kinase inhibitor activity 8/1273 46/18639 0.173913043478261 2.54639844256976 0.0118159364507134 0.197559283181716 GO:0009931 calcium-dependent protein serine/threonine kinase activity 5/1273 21/18639 0.238095238095238 3.48614072494669 0.0119477931055382 0.197559283181716 GO:0019200 carbohydrate kinase activity 5/1273 21/18639 0.238095238095238 3.48614072494669 0.0119477931055382 0.197559283181716 GO:0120013 lipid transfer activity 10/1273 65/18639 0.153846153846154 2.25258323765786 0.0122624193987488 0.199945560751821 GO:0005344 oxygen carrier activity 4/1273 14/18639 0.285714285714286 4.18336886993603 0.0124625275251629 0.200424757733441 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 12/1273 86/18639 0.13953488372093 2.04304061089899 0.0137127282735809 0.209761638190679 GO:0008201 heparin binding 20/1273 172/18639 0.116279069767442 1.70253384241583 0.0137334748435584 0.209761638190679 GO:0004866 endopeptidase inhibitor activity 19/1273 161/18639 0.118012422360248 1.72791322888662 0.0138641285573919 0.209761638190679 GO:0016769 transferase activity, transferring nitrogenous groups 6/1273 30/18639 0.2 2.92835820895522 0.0144355981878088 0.209761638190679 GO:0070566 adenylyltransferase activity 6/1273 30/18639 0.2 2.92835820895522 0.0144355981878088 0.209761638190679 GO:0004601 peroxidase activity 9/1273 57/18639 0.157894736842105 2.31186174391202 0.0145129553208996 0.209761638190679 GO:0000510 H3-H4 histone complex chaperone activity 18/1273 151/18639 0.119205298013245 1.7453790649402 0.0148298262093922 0.209761638190679 GO:0140584 chromatin extrusion motor activity 18/1273 151/18639 0.119205298013245 1.7453790649402 0.0148298262093922 0.209761638190679 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 18/1273 151/18639 0.119205298013245 1.7453790649402 0.0148298262093922 0.209761638190679 GO:0140849 ATP-dependent H2AZ histone chaperone activity 18/1273 151/18639 0.119205298013245 1.7453790649402 0.0148298262093922 0.209761638190679 GO:0032266 phosphatidylinositol-3-phosphate binding 8/1273 48/18639 0.166666666666667 2.44029850746269 0.0151571042248914 0.211838575714553 GO:0015616 DNA translocase activity 18/1273 152/18639 0.118421052631579 1.73389630793401 0.0157848537996427 0.214676639572499 GO:0140674 ATP-dependent histone chaperone activity 18/1273 152/18639 0.118421052631579 1.73389630793401 0.0157848537996427 0.214676639572499 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 4/1273 15/18639 0.266666666666667 3.9044776119403 0.0160916050105451 0.214676639572499 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 4/1273 15/18639 0.266666666666667 3.9044776119403 0.0160916050105451 0.214676639572499 GO:0061775 cohesin loader activity 18/1273 153/18639 0.117647058823529 1.7225636523266 0.016787147457909 0.22035472439142 GO:0070273 phosphatidylinositol-4-phosphate binding 6/1273 31/18639 0.193548387096774 2.83389504092441 0.0168926108988312 0.22035472439142 GO:0004222 metalloendopeptidase activity 14/1273 110/18639 0.127272727272727 1.86350067842605 0.0175890996234268 0.220361036600113 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 5/1273 23/18639 0.217391304347826 3.1829980532122 0.0176438990122748 0.220361036600113 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/1273 23/18639 0.217391304347826 3.1829980532122 0.0176438990122748 0.220361036600113 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 5/1273 23/18639 0.217391304347826 3.1829980532122 0.0176438990122748 0.220361036600113 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/1273 59/18639 0.152542372881356 2.23349354920314 0.0179600408284022 0.221948294026781 GO:0005319 lipid transporter activity 20/1273 178/18639 0.112359550561798 1.6451450612108 0.0193397794531252 0.236123622986601 GO:0120015 sterol transfer activity 6/1273 32/18639 0.1875 2.74533582089552 0.0196226583144941 0.236123622986601 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 9/1273 60/18639 0.15 2.19626865671642 0.0198907044313986 0.236123622986601 GO:0140996 histone H3 kinase activity 35/1273 357/18639 0.0980392156862745 1.43546971027217 0.0199116172705907 0.236123622986601 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 4/1273 16/18639 0.25 3.66044776119403 0.0203188547795802 0.23618153971512 GO:0055102 lipase inhibitor activity 4/1273 16/18639 0.25 3.66044776119403 0.0203188547795802 0.23618153971512 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/1273 24/18639 0.208333333333333 3.05037313432836 0.0210654590042144 0.237796623759113 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/1273 24/18639 0.208333333333333 3.05037313432836 0.0210654590042144 0.237796623759113 GO:0035035 histone acetyltransferase binding 5/1273 24/18639 0.208333333333333 3.05037313432836 0.0210654590042144 0.237796623759113 GO:0005010 insulin-like growth factor receptor activity 8/1273 51/18639 0.156862745098039 2.29675153643547 0.021379299683948 0.239040931704333 GO:0030414 peptidase inhibitor activity 19/1273 169/18639 0.112426035502959 1.6461185198269 0.022089648087991 0.243378059669754 GO:0035173 histone kinase activity 35/1273 360/18639 0.0972222222222222 1.42350746268657 0.0222644800400512 0.243378059669754 GO:0019207 kinase regulator activity 29/1273 287/18639 0.101045296167247 1.47948411253835 0.0223891230360592 0.243378059669754 GO:0002020 protease binding 16/1273 136/18639 0.117647058823529 1.7225636523266 0.0232222844212272 0.247845108277461 GO:0016779 nucleotidyltransferase activity 16/1273 136/18639 0.117647058823529 1.7225636523266 0.0232222844212272 0.247845108277461 GO:0005080 protein kinase C binding 8/1273 52/18639 0.153846153846154 2.25258323765786 0.0238044218765674 0.250019868061497 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/1273 17/18639 0.235294117647059 3.4451273046532 0.0251670990097066 0.250019868061497 GO:0019198 transmembrane receptor protein phosphatase activity 4/1273 17/18639 0.235294117647059 3.4451273046532 0.0251670990097066 0.250019868061497 GO:0003689 DNA clamp loader activity 18/1273 160/18639 0.1125 1.64720149253731 0.0252500520881767 0.250019868061497 GO:0005539 glycosaminoglycan binding 25/1273 242/18639 0.103305785123967 1.51258171950167 0.0254509210710408 0.250019868061497 GO:0008376 acetylgalactosaminyltransferase activity 6/1273 34/18639 0.176470588235294 2.5838454784899 0.0259496874916917 0.250019868061497 GO:0005544 calcium-dependent phospholipid binding 8/1273 53/18639 0.150943396226415 2.21008166713602 0.0264160611516508 0.250019868061497 GO:0005522 profilin binding 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.250019868061497 GO:0008190 eukaryotic initiation factor 4E binding 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.250019868061497 GO:0030957 Tat protein binding 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.250019868061497 GO:0035374 chondroitin sulfate binding 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.250019868061497 GO:0070513 death domain binding 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.250019868061497 GO:1905394 retromer complex binding 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.250019868061497 GO:0061135 endopeptidase regulator activity 20/1273 184/18639 0.108695652173913 1.5914990266061 0.0265759252353201 0.250019868061497 GO:0019887 protein kinase regulator activity 26/1273 255/18639 0.101960784313725 1.49288849868306 0.0266205140610622 0.250019868061497 GO:0004860 protein kinase inhibitor activity 11/1273 84/18639 0.130952380952381 1.91737739872068 0.0273712987178212 0.255030989640651 GO:0019208 phosphatase regulator activity 14/1273 117/18639 0.11965811965812 1.75200918484501 0.0284342529057976 0.261867609812895 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.261867609812895 GO:0050750 low-density lipoprotein particle receptor binding 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.261867609812895 GO:0120014 phospholipid transfer activity 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.261867609812895 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 8/1273 54/18639 0.148148148148148 2.16915422885572 0.0292203210268222 0.261867609812895 GO:0019888 protein phosphatase regulator activity 13/1273 107/18639 0.121495327102804 1.77890919235598 0.0304034316197319 0.268557506354721 GO:0070064 proline-rich region binding 4/1273 18/18639 0.222222222222222 3.25373134328358 0.0306530714237926 0.268557506354721 GO:1901611 phosphatidylglycerol binding 4/1273 18/18639 0.222222222222222 3.25373134328358 0.0306530714237926 0.268557506354721 GO:0031406 carboxylic acid binding 20/1273 187/18639 0.106951871657754 1.56596695666055 0.0308861154522041 0.268594811413982 GO:0140713 histone chaperone activity 18/1273 164/18639 0.109756097560976 1.60702584637787 0.0313506035221593 0.270629474522169 GO:0004715 non-membrane spanning protein tyrosine kinase activity 7/1273 45/18639 0.155555555555556 2.27761194029851 0.0316734932299329 0.271421029576213 GO:0098632 cell-cell adhesion mediator activity 8/1273 55/18639 0.145454545454545 2.12971506105834 0.0322229348666844 0.273106384732605 GO:0005044 scavenger receptor activity 5/1273 27/18639 0.185185185185185 2.71144278606965 0.033811072587135 0.273106384732605 GO:0043177 organic acid binding 20/1273 189/18639 0.105820105820106 1.54939587775409 0.0340373041702002 0.273106384732605 GO:0008081 phosphoric diester hydrolase activity 11/1273 87/18639 0.126436781609195 1.85126093669583 0.0343532792337436 0.273106384732605 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.273106384732605 GO:0005114 type II transforming growth factor beta receptor binding 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.273106384732605 GO:0008526 phosphatidylinositol transfer activity 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.273106384732605 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.273106384732605 GO:0042608 T cell receptor binding 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.273106384732605 GO:0048185 activin binding 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.273106384732605 GO:0048407 platelet-derived growth factor binding 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.273106384732605 GO:0097493 structural molecule activity conferring elasticity 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.273106384732605 GO:0061134 peptidase regulator activity 23/1273 226/18639 0.101769911504425 1.49009377889314 0.0360434778918277 0.276413207020445 GO:0003724 RNA helicase activity 10/1273 77/18639 0.12987012987013 1.90153130451638 0.0361895244606663 0.276413207020445 GO:0005520 insulin-like growth factor binding 4/1273 19/18639 0.210526315789474 3.08248232521602 0.0367876029739276 0.276413207020445 GO:0008301 DNA binding, bending 4/1273 19/18639 0.210526315789474 3.08248232521602 0.0367876029739276 0.276413207020445 GO:0043395 heparan sulfate proteoglycan binding 4/1273 19/18639 0.210526315789474 3.08248232521602 0.0367876029739276 0.276413207020445 GO:1990380 K48-linked deubiquitinase activity 4/1273 19/18639 0.210526315789474 3.08248232521602 0.0367876029739276 0.276413207020445 GO:0004197 cysteine-type endopeptidase activity 11/1273 88/18639 0.125 1.83022388059702 0.0369366380405321 0.276413207020445 GO:0019903 protein phosphatase binding 16/1273 144/18639 0.111111111111111 1.62686567164179 0.0369649689115928 0.276413207020445 GO:0008017 microtubule binding 27/1273 276/18639 0.0978260869565217 1.43234912394549 0.0381102015181934 0.281436804466001 GO:0045499 chemorepellent activity 5/1273 28/18639 0.178571428571429 2.61460554371002 0.038924920791605 0.281436804466001 GO:0046875 ephrin receptor binding 5/1273 28/18639 0.178571428571429 2.61460554371002 0.038924920791605 0.281436804466001 GO:0141052 histone H3 demethylase activity 5/1273 28/18639 0.178571428571429 2.61460554371002 0.038924920791605 0.281436804466001 GO:0001784 phosphotyrosine residue binding 7/1273 47/18639 0.148936170212766 2.18069228326453 0.0390573853718558 0.281436804466001 GO:0019199 transmembrane receptor protein kinase activity 10/1273 78/18639 0.128205128205128 1.87715269804822 0.039075127025518 0.281436804466001 GO:0030145 manganese ion binding 9/1273 68/18639 0.132352941176471 1.93788410886743 0.0409940427435613 0.293457354761835 GO:0008186 ATP-dependent activity, acting on RNA 10/1273 79/18639 0.126582278481013 1.85339127149065 0.0421151477851216 0.298069521339123 GO:0019210 kinase inhibitor activity 11/1273 90/18639 0.122222222222222 1.78955223880597 0.0425048547134018 0.298069521339123 GO:0141003 histone H2AX kinase activity 33/1273 354/18639 0.0932203389830508 1.36491272451303 0.0429572662981012 0.298069521339123 GO:0038187 pattern recognition receptor activity 7/1273 48/18639 0.145833333333333 2.13526119402985 0.043137921177435 0.298069521339123 GO:0031418 L-ascorbic acid binding 4/1273 20/18639 0.2 2.92835820895522 0.0435758846656618 0.298069521339123 GO:0004300 enoyl-CoA hydratase activity 3/1273 12/18639 0.25 3.66044776119403 0.0439233621734823 0.298069521339123 GO:0004859 phospholipase inhibitor activity 3/1273 12/18639 0.25 3.66044776119403 0.0439233621734823 0.298069521339123 GO:0016208 AMP binding 3/1273 12/18639 0.25 3.66044776119403 0.0439233621734823 0.298069521339123 GO:0031543 peptidyl-proline dioxygenase activity 3/1273 12/18639 0.25 3.66044776119403 0.0439233621734823 0.298069521339123 GO:0072341 modified amino acid binding 11/1273 91/18639 0.120879120879121 1.76988682958832 0.0454949894418365 0.306960446004115 GO:0008237 metallopeptidase activity 19/1273 184/18639 0.103260869565217 1.51192407527579 0.0469251702509448 0.314800856426338 GO:0016763 pentosyltransferase activity 7/1273 49/18639 0.142857142857143 2.09168443496802 0.0474838202119394 0.316738664368277 GO:0097110 scaffold protein binding 9/1273 70/18639 0.128571428571429 1.88251599147122 0.0480051096045339 0.318406772179225 GO:0001618 virus receptor activity 10/1273 81/18639 0.123456790123457 1.80762852404643 0.0486700981181375 0.321003905565693 GO:0004714 transmembrane receptor protein tyrosine kinase activity 8/1273 60/18639 0.133333333333333 1.95223880597015 0.050382744825941 0.325515672673792 GO:0001968 fibronectin binding 5/1273 30/18639 0.166666666666667 2.44029850746269 0.0504943911999667 0.325515672673792 GO:0031210 phosphatidylcholine binding 5/1273 30/18639 0.166666666666667 2.44029850746269 0.0504943911999667 0.325515672673792 GO:0032452 histone demethylase activity 5/1273 30/18639 0.166666666666667 2.44029850746269 0.0504943911999667 0.325515672673792 GO:0008094 ATP-dependent activity, acting on DNA 21/1273 210/18639 0.1 1.46417910447761 0.050963491498163 0.325515672673792 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4/1273 21/18639 0.19047619047619 2.78891257995736 0.0510177885621616 0.325515672673792 GO:0140272 exogenous protein binding 10/1273 82/18639 0.121951219512195 1.78558427375319 0.0521902635647391 0.328034974290935 GO:0030295 protein kinase activator activity 15/1273 139/18639 0.107913669064748 1.58004939332116 0.0524874218739498 0.328034974290935 GO:0015036 disulfide oxidoreductase activity 6/1273 40/18639 0.15 2.19626865671642 0.0525303025269981 0.328034974290935 GO:0050997 quaternary ammonium group binding 6/1273 40/18639 0.15 2.19626865671642 0.0525303025269981 0.328034974290935 GO:0005035 death receptor activity 3/1273 13/18639 0.230769230769231 3.3788748564868 0.0542795831954488 0.330177360992005 GO:0008035 high-density lipoprotein particle binding 3/1273 13/18639 0.230769230769231 3.3788748564868 0.0542795831954488 0.330177360992005 GO:0031994 insulin-like growth factor I binding 3/1273 13/18639 0.230769230769231 3.3788748564868 0.0542795831954488 0.330177360992005 GO:0089720 caspase binding 3/1273 13/18639 0.230769230769231 3.3788748564868 0.0542795831954488 0.330177360992005 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/1273 13/18639 0.230769230769231 3.3788748564868 0.0542795831954488 0.330177360992005 GO:0016836 hydro-lyase activity 8/1273 61/18639 0.131147540983607 1.92023489111818 0.0546719387516543 0.330424697810672 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 32/1273 349/18639 0.0916905444126074 1.34251379207116 0.0548831482734932 0.330424697810672 GO:0005518 collagen binding 9/1273 72/18639 0.125 1.83022388059702 0.0557667719824852 0.33298275069494 GO:0001540 amyloid-beta binding 10/1273 83/18639 0.120481927710843 1.76407121021399 0.0558752997333077 0.33298275069494 GO:0070325 lipoprotein particle receptor binding 5/1273 31/18639 0.161290322580645 2.36157920077034 0.0569562720271081 0.336013383717713 GO:0140457 protein demethylase activity 5/1273 31/18639 0.161290322580645 2.36157920077034 0.0569562720271081 0.336013383717713 GO:1901681 sulfur compound binding 26/1273 275/18639 0.0945454545454545 1.38431478968792 0.0578731367254985 0.338502746829309 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 6/1273 41/18639 0.146341463414634 2.14270112850382 0.05813397924354 0.338502746829309 GO:0003774 cytoskeletal motor activity 16/1273 153/18639 0.104575163398693 1.53116769095698 0.0585679313365943 0.338502746829309 GO:0008093 cytoskeletal anchor activity 4/1273 22/18639 0.181818181818182 2.66214382632293 0.059108230919939 0.338502746829309 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/1273 22/18639 0.181818181818182 2.66214382632293 0.059108230919939 0.338502746829309 GO:0033691 sialic acid binding 4/1273 22/18639 0.181818181818182 2.66214382632293 0.059108230919939 0.338502746829309 GO:0043539 protein serine/threonine kinase activator activity 9/1273 73/18639 0.123287671232877 1.80515232058884 0.059935235208612 0.341572651140342 GO:0016887 ATP hydrolysis activity 37/1273 417/18639 0.0887290167865707 1.2991517233974 0.0617336612462228 0.348928921208052 GO:0004175 endopeptidase activity 36/1273 405/18639 0.0888888888888889 1.30149253731343 0.0633061214930703 0.348928921208052 GO:0031369 translation initiation factor binding 5/1273 32/18639 0.15625 2.28777985074627 0.0638699041961107 0.348928921208052 GO:0071813 lipoprotein particle binding 5/1273 32/18639 0.15625 2.28777985074627 0.0638699041961107 0.348928921208052 GO:0071814 protein-lipid complex binding 5/1273 32/18639 0.15625 2.28777985074627 0.0638699041961107 0.348928921208052 GO:0031492 nucleosomal DNA binding 6/1273 42/18639 0.142857142857143 2.09168443496802 0.0640811691566577 0.348928921208052 GO:0001217 DNA-binding transcription repressor activity 26/1273 278/18639 0.0935251798561151 1.36937614087834 0.0641933815771706 0.348928921208052 GO:0031491 nucleosome binding 9/1273 74/18639 0.121621621621622 1.78075837031061 0.064298016474538 0.348928921208052 GO:0004386 helicase activity 16/1273 155/18639 0.103225806451613 1.51141068849302 0.064346910908265 0.348928921208052 GO:0005347 ATP transmembrane transporter activity 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.348928921208052 GO:0005545 1-phosphatidylinositol binding 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.348928921208052 GO:0008191 metalloendopeptidase inhibitor activity 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.348928921208052 GO:0008559 ABC-type xenobiotic transporter activity 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.348928921208052 GO:0019992 diacylglycerol binding 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.348928921208052 GO:0042043 neurexin family protein binding 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.348928921208052 GO:0004864 protein phosphatase inhibitor activity 7/1273 53/18639 0.132075471698113 1.93382145874402 0.0675850769809847 0.355541518218645 GO:0140296 general transcription initiation factor binding 7/1273 53/18639 0.132075471698113 1.93382145874402 0.0675850769809847 0.355541518218645 GO:0070577 lysine-acetylated histone binding 4/1273 23/18639 0.173913043478261 2.54639844256976 0.0678375639531315 0.355541518218645 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 18/1273 181/18639 0.0994475138121547 1.45608971716006 0.0697291831310328 0.3638313822037 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 25/1273 268/18639 0.0932835820895522 1.36583871686344 0.07007644740779 0.364025439189139 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/1273 33/18639 0.151515151515152 2.21845318860244 0.0712327533959257 0.366403348254909 GO:0071889 14-3-3 protein binding 5/1273 33/18639 0.151515151515152 2.21845318860244 0.0712327533959257 0.366403348254909 GO:0003713 transcription coactivator activity 24/1273 256/18639 0.09375 1.37266791044776 0.0714704997873715 0.366403348254909 GO:0140297 DNA-binding transcription factor binding 42/1273 488/18639 0.0860655737704918 1.26015414729631 0.0721575768651348 0.368317370607253 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 13/1273 122/18639 0.10655737704918 1.56019084903352 0.0732076651758301 0.370903331638962 GO:0051287 NAD binding 7/1273 54/18639 0.12962962962963 1.89800995024876 0.0732989768039452 0.370903331638962 GO:0098631 cell adhesion mediator activity 9/1273 76/18639 0.118421052631579 1.73389630793401 0.0736119900101177 0.370903331638962 GO:0015631 tubulin binding 34/1273 385/18639 0.0883116883116883 1.29304128707114 0.0744878136101597 0.372637107370444 GO:0001046 core promoter sequence-specific DNA binding 6/1273 44/18639 0.136363636363636 1.9966078697422 0.0770057720209464 0.372637107370444 GO:0001223 transcription coactivator binding 6/1273 44/18639 0.136363636363636 1.9966078697422 0.0770057720209464 0.372637107370444 GO:0019205 nucleobase-containing compound kinase activity 6/1273 44/18639 0.136363636363636 1.9966078697422 0.0770057720209464 0.372637107370444 GO:0015149 hexose transmembrane transporter activity 4/1273 24/18639 0.166666666666667 2.44029850746269 0.0771919849429149 0.372637107370444 GO:0030215 semaphorin receptor binding 4/1273 24/18639 0.166666666666667 2.44029850746269 0.0771919849429149 0.372637107370444 GO:0048027 mRNA 5'-UTR binding 4/1273 24/18639 0.166666666666667 2.44029850746269 0.0771919849429149 0.372637107370444 GO:0050431 transforming growth factor beta binding 4/1273 24/18639 0.166666666666667 2.44029850746269 0.0771919849429149 0.372637107370444 GO:0055056 D-glucose transmembrane transporter activity 4/1273 24/18639 0.166666666666667 2.44029850746269 0.0771919849429149 0.372637107370444 GO:0140033 acetylation-dependent protein binding 4/1273 24/18639 0.166666666666667 2.44029850746269 0.0771919849429149 0.372637107370444 GO:0044389 ubiquitin-like protein ligase binding 29/1273 322/18639 0.0900621118012422 1.31867062204505 0.0775462224785225 0.372637107370444 GO:0047372 monoacylglycerol lipase activity 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.372637107370444 GO:0050700 CARD domain binding 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.372637107370444 GO:0106310 protein serine kinase activity 32/1273 361/18639 0.0886426592797784 1.2978872948278 0.0784552828775731 0.372900818211623 GO:0090482 vitamin transmembrane transporter activity 5/1273 34/18639 0.147058823529412 2.15320456540825 0.0790401785518281 0.374166006531638 GO:0019209 kinase activator activity 15/1273 148/18639 0.101351351351351 1.48396530859217 0.0809232936135379 0.381541954627685 GO:0003727 single-stranded RNA binding 10/1273 89/18639 0.112359550561798 1.6451450612108 0.0815399627121604 0.382911664896305 GO:0016500 protein-hormone receptor activity 8/1273 67/18639 0.119402985074627 1.74827355758521 0.08520584473877 0.393835429765376 GO:0019212 phosphatase inhibitor activity 7/1273 56/18639 0.125 1.83022388059702 0.0855549465112398 0.393835429765376 GO:0030170 pyridoxal phosphate binding 7/1273 56/18639 0.125 1.83022388059702 0.0855549465112398 0.393835429765376 GO:0140104 molecular carrier activity 23/1273 249/18639 0.0923694779116466 1.35245459449739 0.0864833895192372 0.393835429765376 GO:0004709 MAP kinase kinase kinase activity 4/1273 25/18639 0.16 2.34268656716418 0.0871539533394483 0.393835429765376 GO:0008483 transaminase activity 4/1273 25/18639 0.16 2.34268656716418 0.0871539533394483 0.393835429765376 GO:0015662 P-type ion transporter activity 4/1273 25/18639 0.16 2.34268656716418 0.0871539533394483 0.393835429765376 GO:0017025 TBP-class protein binding 4/1273 25/18639 0.16 2.34268656716418 0.0871539533394483 0.393835429765376 GO:0140358 P-type transmembrane transporter activity 4/1273 25/18639 0.16 2.34268656716418 0.0871539533394483 0.393835429765376 GO:0043015 gamma-tubulin binding 5/1273 35/18639 0.142857142857143 2.09168443496802 0.0872855412993832 0.393835429765376 GO:0008083 growth factor activity 16/1273 162/18639 0.0987654320987654 1.44610281923715 0.0875562582357437 0.393835429765376 GO:0019842 vitamin binding 15/1273 150/18639 0.1 1.46417910447761 0.0883767059275637 0.396008598316641 GO:0008234 cysteine-type peptidase activity 18/1273 187/18639 0.0962566844919786 1.40937026099449 0.0887220329295411 0.396044359921222 GO:0016835 carbon-oxygen lyase activity 9/1273 79/18639 0.113924050632911 1.66805214434158 0.0890644683912468 0.39606699201259 GO:0005548 phospholipid transporter activity 8/1273 68/18639 0.117647058823529 1.7225636523266 0.0911007516714646 0.400441058575312 GO:0032934 sterol binding 8/1273 68/18639 0.117647058823529 1.7225636523266 0.0911007516714646 0.400441058575312 GO:0005159 insulin-like growth factor receptor binding 3/1273 16/18639 0.1875 2.74533582089552 0.0914124392659144 0.400441058575312 GO:0005521 lamin binding 3/1273 16/18639 0.1875 2.74533582089552 0.0914124392659144 0.400441058575312 GO:0070279 vitamin B6 binding 7/1273 57/18639 0.12280701754386 1.79811468970935 0.0920944592774563 0.400825029157068 GO:0140597 protein carrier chaperone 18/1273 188/18639 0.0957446808510638 1.40187361067005 0.0921829283410633 0.400825029157068 GO:0004033 aldo-keto reductase (NADPH) activity 5/1273 36/18639 0.138888888888889 2.03358208955224 0.0959603255995104 0.415710045217067 GO:0005160 transforming growth factor beta receptor binding 4/1273 26/18639 0.153846153846154 2.25258323765786 0.0977026081787839 0.416231679815852 GO:0015145 monosaccharide transmembrane transporter activity 4/1273 26/18639 0.153846153846154 2.25258323765786 0.0977026081787839 0.416231679815852 GO:0050681 nuclear androgen receptor binding 4/1273 26/18639 0.153846153846154 2.25258323765786 0.0977026081787839 0.416231679815852 GO:0070006 metalloaminopeptidase activity 4/1273 26/18639 0.153846153846154 2.25258323765786 0.0977026081787839 0.416231679815852 GO:0031490 chromatin DNA binding 13/1273 128/18639 0.1015625 1.48705690298507 0.0978534443178664 0.416231679815852 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7/1273 58/18639 0.120689655172414 1.76711271230057 0.0989053700834113 0.417805920071532 GO:0140359 ABC-type transporter activity 6/1273 47/18639 0.127659574468085 1.86916481422674 0.0989353030493065 0.417805920071532 GO:0051213 dioxygenase activity 10/1273 93/18639 0.10752688172043 1.57438613384689 0.102094173290982 0.42806628372719 GO:0051219 phosphoprotein binding 10/1273 93/18639 0.10752688172043 1.57438613384689 0.102094173290982 0.42806628372719 GO:0015399 primary active transmembrane transporter activity 16/1273 166/18639 0.0963855421686747 1.41125696817119 0.102953463961867 0.42905471566841 GO:0004550 nucleoside diphosphate kinase activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.42905471566841 GO:0005092 GDP-dissociation inhibitor activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.42905471566841 GO:0030169 low-density lipoprotein particle binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.42905471566841 GO:0032183 SUMO binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.42905471566841 GO:0036041 long-chain fatty acid binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.42905471566841 GO:0038191 neuropilin binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.42905471566841 GO:0048038 quinone binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.42905471566841 GO:0031593 polyubiquitin modification-dependent protein binding 7/1273 59/18639 0.11864406779661 1.73716164938022 0.105984554977716 0.42905471566841 GO:0045309 protein phosphorylated amino acid binding 7/1273 59/18639 0.11864406779661 1.73716164938022 0.105984554977716 0.42905471566841 GO:0140693 molecular condensate scaffold activity 6/1273 48/18639 0.125 1.83022388059702 0.106906357602431 0.431299188402934 GO:0035255 ionotropic glutamate receptor binding 4/1273 27/18639 0.148148148148148 2.16915422885572 0.108814179586027 0.437492626143822 GO:0031072 heat shock protein binding 13/1273 131/18639 0.099236641221374 1.45300216474878 0.11186504239059 0.441968315691179 GO:0030165 PDZ domain binding 9/1273 83/18639 0.108433734939759 1.58766408919259 0.112422537464595 0.441968315691179 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 7/1273 60/18639 0.116666666666667 1.70820895522388 0.113328190280781 0.441968315691179 GO:0004867 serine-type endopeptidase inhibitor activity 10/1273 95/18639 0.105263157894737 1.54124116260801 0.113401679711622 0.441968315691179 GO:0005004 GPI-linked ephrin receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0005008 hepatocyte growth factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0005009 insulin receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0005011 macrophage colony-stimulating factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0005018 platelet-derived growth factor alpha-receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0005020 stem cell factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0008288 boss receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0036332 placental growth factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0038062 protein tyrosine kinase collagen receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0060175 brain-derived neurotrophic factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.441968315691179 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 13/1273 132/18639 0.0984848484848485 1.44199457259159 0.116784571455891 0.446596374231975 GO:0019789 SUMO transferase activity 4/1273 28/18639 0.142857142857143 2.09168443496802 0.120462389385098 0.453791747207882 GO:0051119 sugar transmembrane transporter activity 4/1273 28/18639 0.142857142857143 2.09168443496802 0.120462389385098 0.453791747207882 GO:0004706 JUN kinase kinase kinase activity 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.453791747207882 GO:0032393 MHC class I receptor activity 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.453791747207882 GO:0034185 apolipoprotein binding 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.453791747207882 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 40/1273 484/18639 0.0826446280991736 1.21006537560133 0.121258693916251 0.454232024671503 GO:0033218 amide binding 22/1273 247/18639 0.0890688259109312 1.3041271375914 0.121876565393121 0.454232024671503 GO:0042393 histone binding 22/1273 247/18639 0.0890688259109312 1.3041271375914 0.121876565393121 0.454232024671503 GO:0005006 epidermal growth factor receptor activity 6/1273 50/18639 0.12 1.75701492537313 0.123802284650007 0.455623455106921 GO:0005007 fibroblast growth factor receptor activity 6/1273 50/18639 0.12 1.75701492537313 0.123802284650007 0.455623455106921 GO:0005017 platelet-derived growth factor receptor activity 6/1273 50/18639 0.12 1.75701492537313 0.123802284650007 0.455623455106921 GO:0005019 platelet-derived growth factor beta-receptor activity 6/1273 50/18639 0.12 1.75701492537313 0.123802284650007 0.455623455106921 GO:0051087 protein-folding chaperone binding 13/1273 134/18639 0.0970149253731343 1.42047226553798 0.126993406348199 0.465907059539954 GO:0042626 ATPase-coupled transmembrane transporter activity 10/1273 98/18639 0.102040816326531 1.49406031069144 0.13162412940134 0.476461305709736 GO:0031625 ubiquitin protein ligase binding 26/1273 302/18639 0.0860927152317881 1.26055154690126 0.13239666532163 0.476461305709736 GO:0003785 actin monomer binding 4/1273 29/18639 0.137931034482759 2.01955738548636 0.132618836908376 0.476461305709736 GO:0004629 phospholipase C activity 4/1273 29/18639 0.137931034482759 2.01955738548636 0.132618836908376 0.476461305709736 GO:0005021 vascular endothelial growth factor receptor activity 6/1273 51/18639 0.117647058823529 1.7225636523266 0.132711113259867 0.476461305709736 GO:0005030 neurotrophin receptor activity 6/1273 51/18639 0.117647058823529 1.7225636523266 0.132711113259867 0.476461305709736 GO:0005272 sodium channel activity 6/1273 51/18639 0.117647058823529 1.7225636523266 0.132711113259867 0.476461305709736 GO:0004177 aminopeptidase activity 5/1273 40/18639 0.125 1.83022388059702 0.134724926541952 0.477707376823536 GO:0032451 demethylase activity 5/1273 40/18639 0.125 1.83022388059702 0.134724926541952 0.477707376823536 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.477707376823536 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.477707376823536 GO:0030506 ankyrin binding 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.477707376823536 GO:0031420 alkali metal ion binding 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.477707376823536 GO:0097001 ceramide binding 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.477707376823536 GO:0140036 ubiquitin-modified protein reader activity 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.477707376823536 GO:0001216 DNA-binding transcription activator activity 40/1273 491/18639 0.0814663951120163 1.19281393440131 0.140360239687781 0.478476512887792 GO:0030159 signaling receptor complex adaptor activity 6/1273 52/18639 0.115384615384615 1.6894374282434 0.141915041972548 0.478476512887792 GO:0001965 G-protein alpha-subunit binding 4/1273 30/18639 0.133333333333333 1.95223880597015 0.145253367017362 0.478476512887792 GO:0031624 ubiquitin conjugating enzyme binding 4/1273 30/18639 0.133333333333333 1.95223880597015 0.145253367017362 0.478476512887792 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/1273 41/18639 0.121951219512195 1.78558427375319 0.145362558111176 0.478476512887792 GO:0042169 SH2 domain binding 5/1273 41/18639 0.121951219512195 1.78558427375319 0.145362558111176 0.478476512887792 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0004090 carbonyl reductase (NADPH) activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0005131 growth hormone receptor binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0005345 purine nucleobase transmembrane transporter activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0008140 cAMP response element binding protein binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0008519 ammonium channel activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0015187 glycine transmembrane transporter activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0031419 cobalamin binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0031434 mitogen-activated protein kinase kinase binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0050308 sugar-phosphatase activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0051864 histone H3K36 demethylase activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.478476512887792 GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/1273 88/18639 0.102272727272727 1.49745590230665 0.145906807166805 0.478476512887792 GO:0005003 ephrin receptor activity 6/1273 53/18639 0.113207547169811 1.65756125035201 0.151403973673598 0.492377465631037 GO:0005005 transmembrane-ephrin receptor activity 6/1273 53/18639 0.113207547169811 1.65756125035201 0.151403973673598 0.492377465631037 GO:0038064 collagen receptor activity 6/1273 53/18639 0.113207547169811 1.65756125035201 0.151403973673598 0.492377465631037 GO:0070851 growth factor receptor binding 13/1273 139/18639 0.0935251798561151 1.36937614087834 0.154625011419745 0.501463434825361 GO:0000287 magnesium ion binding 20/1273 230/18639 0.0869565217391304 1.27319922128488 0.158796553961879 0.513573427964865 GO:0140097 catalytic activity, acting on DNA 28/1273 336/18639 0.0833333333333333 1.22014925373134 0.159834326133866 0.515509612310875 GO:0015485 cholesterol binding 6/1273 54/18639 0.111111111111111 1.62686567164179 0.161167098282305 0.515927507315611 GO:0017124 SH3 domain binding 11/1273 115/18639 0.0956521739130435 1.40051914341337 0.161889774330975 0.515927507315611 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 12/1273 128/18639 0.09375 1.37266791044776 0.164581104594367 0.515927507315611 GO:0004722 protein serine/threonine phosphatase activity 10/1273 103/18639 0.0970873786407767 1.42153311114331 0.165215254617194 0.515927507315611 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/1273 43/18639 0.116279069767442 1.70253384241583 0.167658954282084 0.515927507315611 GO:0008375 acetylglucosaminyltransferase activity 5/1273 43/18639 0.116279069767442 1.70253384241583 0.167658954282084 0.515927507315611 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.515927507315611 GO:0036122 BMP binding 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.515927507315611 GO:0140312 cargo adaptor activity 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.515927507315611 GO:0002162 dystroglycan binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0008046 axon guidance receptor activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0008199 ferric iron binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0008432 JUN kinase binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0015205 nucleobase transmembrane transporter activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0015217 ADP transmembrane transporter activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0019203 carbohydrate phosphatase activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0032794 GTPase activating protein binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.515927507315611 GO:0140313 molecular sequestering activity 6/1273 55/18639 0.109090909090909 1.59728629579376 0.171192959347102 0.515927507315611 GO:0050840 extracellular matrix binding 7/1273 67/18639 0.104477611940299 1.52973936288706 0.171683105049988 0.515927507315611 GO:0042910 xenobiotic transmembrane transporter activity 4/1273 32/18639 0.125 1.83022388059702 0.171829348688589 0.515927507315611 GO:0051059 NF-kappaB binding 4/1273 32/18639 0.125 1.83022388059702 0.171829348688589 0.515927507315611 GO:0043178 alcohol binding 9/1273 92/18639 0.0978260869565217 1.43234912394549 0.175892940911199 0.526781409769765 GO:0035403 histone H3T6 kinase activity 21/1273 247/18639 0.0850202429149798 1.24484863133724 0.176571811948547 0.527468975133828 GO:0003954 NADH dehydrogenase activity 5/1273 44/18639 0.113636363636364 1.66383989145183 0.179281157136076 0.532850831589249 GO:0030547 signaling receptor inhibitor activity 5/1273 44/18639 0.113636363636364 1.66383989145183 0.179281157136076 0.532850831589249 GO:1990841 promoter-specific chromatin binding 7/1273 68/18639 0.102941176470588 1.50724319578578 0.180930260355721 0.536394256711151 GO:0140311 protein sequestering activity 4/1273 33/18639 0.121212121212121 1.77476255088195 0.18570474114275 0.538098976291163 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/1273 22/18639 0.136363636363636 1.9966078697422 0.187072004997848 0.538098976291163 GO:0140035 ubiquitin-like protein reader activity 3/1273 22/18639 0.136363636363636 1.9966078697422 0.187072004997848 0.538098976291163 GO:0140517 protein-RNA adaptor activity 3/1273 22/18639 0.136363636363636 1.9966078697422 0.187072004997848 0.538098976291163 GO:0030971 receptor tyrosine kinase binding 8/1273 81/18639 0.0987654320987654 1.44610281923715 0.187463783052032 0.538098976291163 GO:0033192 calmodulin-dependent protein phosphatase activity 8/1273 81/18639 0.0987654320987654 1.44610281923715 0.187463783052032 0.538098976291163 GO:0140791 histone H2AXS140 phosphatase activity 8/1273 81/18639 0.0987654320987654 1.44610281923715 0.187463783052032 0.538098976291163 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/1273 81/18639 0.0987654320987654 1.44610281923715 0.187463783052032 0.538098976291163 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/1273 81/18639 0.0987654320987654 1.44610281923715 0.187463783052032 0.538098976291163 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/1273 81/18639 0.0987654320987654 1.44610281923715 0.187463783052032 0.538098976291163 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/1273 81/18639 0.0987654320987654 1.44610281923715 0.187463783052032 0.538098976291163 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/1273 81/18639 0.0987654320987654 1.44610281923715 0.187463783052032 0.538098976291163 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/1273 81/18639 0.0987654320987654 1.44610281923715 0.187463783052032 0.538098976291163 GO:0061659 ubiquitin-like protein ligase activity 30/1273 372/18639 0.0806451612903226 1.18078960038517 0.195345784356268 0.542082011030994 GO:0003995 acyl-CoA dehydrogenase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0004000 adenosine deaminase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0005095 GTPase inhibitor activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0008179 adenylate cyclase binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0016840 carbon-nitrogen lyase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0017166 vinculin binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0034452 dynactin binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0045295 gamma-catenin binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0097677 STAT family protein binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.542082011030994 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/1273 82/18639 0.0975609756097561 1.42846741900255 0.196239228865564 0.542082011030994 GO:0033549 MAP kinase phosphatase activity 8/1273 82/18639 0.0975609756097561 1.42846741900255 0.196239228865564 0.542082011030994 GO:0015020 glucuronosyltransferase activity 4/1273 34/18639 0.117647058823529 1.7225636523266 0.199926682821539 0.548397022505812 GO:0015035 protein-disulfide reductase activity 4/1273 34/18639 0.117647058823529 1.7225636523266 0.199926682821539 0.548397022505812 GO:0019825 oxygen binding 4/1273 34/18639 0.117647058823529 1.7225636523266 0.199926682821539 0.548397022505812 GO:0005496 steroid binding 10/1273 108/18639 0.0925925925925926 1.35572139303483 0.202499683716541 0.548703734768438 GO:0004180 carboxypeptidase activity 5/1273 46/18639 0.108695652173913 1.5914990266061 0.203377036430255 0.548703734768438 GO:0140030 modification-dependent protein binding 15/1273 173/18639 0.0867052023121387 1.26951945474937 0.203717998850563 0.548703734768438 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.548703734768438 GO:0003887 DNA-directed DNA polymerase activity 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.548703734768438 GO:0005158 insulin receptor binding 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.548703734768438 GO:0017134 fibroblast growth factor binding 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.548703734768438 GO:0042171 lysophosphatidic acid acyltransferase activity 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.548703734768438 GO:0043274 phospholipase binding 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.548703734768438 GO:0071617 lysophospholipid acyltransferase activity 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.548703734768438 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/1273 83/18639 0.0963855421686747 1.41125696817119 0.205179675948334 0.548703734768438 GO:0016829 lyase activity 17/1273 200/18639 0.085 1.24455223880597 0.207367632674111 0.553294547180468 GO:0017018 myosin phosphatase activity 8/1273 84/18639 0.0952380952380952 1.39445628997868 0.214277959843016 0.568345918240381 GO:0000175 3'-5'-RNA exonuclease activity 4/1273 35/18639 0.114285714285714 1.67334754797441 0.214461023663108 0.568345918240381 GO:0140566 histone reader activity 4/1273 35/18639 0.114285714285714 1.67334754797441 0.214461023663108 0.568345918240381 GO:0005504 fatty acid binding 5/1273 47/18639 0.106382978723404 1.55763734518895 0.215810576118463 0.568786867791248 GO:0044325 transmembrane transporter binding 12/1273 136/18639 0.0882352941176471 1.29192273924495 0.218798555910747 0.568786867791248 GO:0008253 5'-nucleotidase activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0017154 semaphorin receptor activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0030955 potassium ion binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0031432 titin binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0032396 inhibitory MHC class I receptor activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0035325 Toll-like receptor binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0039706 co-receptor binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0043560 insulin receptor substrate binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0045159 myosin II binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0051011 microtubule minus-end binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0071837 HMG box domain binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0140852 histone ubiquitin ligase activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.568786867791248 GO:0004622 lysophospholipase activity 3/1273 24/18639 0.125 1.83022388059702 0.223209340613361 0.569669056261056 GO:0050699 WW domain binding 3/1273 24/18639 0.125 1.83022388059702 0.223209340613361 0.569669056261056 GO:0070300 phosphatidic acid binding 3/1273 24/18639 0.125 1.83022388059702 0.223209340613361 0.569669056261056 GO:0000993 RNA polymerase II complex binding 4/1273 36/18639 0.111111111111111 1.62686567164179 0.229273610921058 0.576375201758719 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/1273 36/18639 0.111111111111111 1.62686567164179 0.229273610921058 0.576375201758719 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/1273 36/18639 0.111111111111111 1.62686567164179 0.229273610921058 0.576375201758719 GO:0045505 dynein intermediate chain binding 4/1273 36/18639 0.111111111111111 1.62686567164179 0.229273610921058 0.576375201758719 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/1273 36/18639 0.111111111111111 1.62686567164179 0.229273610921058 0.576375201758719 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/1273 36/18639 0.111111111111111 1.62686567164179 0.229273610921058 0.576375201758719 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/1273 36/18639 0.111111111111111 1.62686567164179 0.229273610921058 0.576375201758719 GO:0015026 coreceptor activity 6/1273 61/18639 0.0983606557377049 1.44017616833863 0.236159336927011 0.592416798188699 GO:0046906 tetrapyrrole binding 13/1273 152/18639 0.0855263157894737 1.25225844461901 0.239227359455341 0.598833518124883 GO:0035254 glutamate receptor binding 5/1273 49/18639 0.102040816326531 1.49406031069144 0.241346128124626 0.602851817911299 GO:0070001 aspartic-type peptidase activity 4/1273 37/18639 0.108108108108108 1.58289632916499 0.244330501307025 0.607543897655936 GO:0035402 histone H3T11 kinase activity 20/1273 247/18639 0.0809716599190283 1.18557012508309 0.245787217601097 0.607543897655936 GO:0004705 JUN kinase activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.607543897655936 GO:0005161 platelet-derived growth factor receptor binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.607543897655936 GO:0032454 histone H3K9 demethylase activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.607543897655936 GO:0034236 protein kinase A catalytic subunit binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.607543897655936 GO:0061665 SUMO ligase activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.607543897655936 GO:1901612 cardiolipin binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.607543897655936 GO:0004679 AMP-activated protein kinase activity 20/1273 248/18639 0.0806451612903226 1.18078960038517 0.25144510679338 0.616276733560394 GO:0005506 iron ion binding 13/1273 154/18639 0.0844155844155844 1.23599534793565 0.253641449190405 0.620364711144866 GO:0032813 tumor necrosis factor receptor superfamily binding 5/1273 50/18639 0.1 1.46417910447761 0.254406555177361 0.620942402865327 GO:0000146 microfilament motor activity 4/1273 38/18639 0.105263157894737 1.54124116260801 0.259598151210607 0.621301662710185 GO:0005109 frizzled binding 4/1273 38/18639 0.105263157894737 1.54124116260801 0.259598151210607 0.621301662710185 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 4/1273 38/18639 0.105263157894737 1.54124116260801 0.259598151210607 0.621301662710185 GO:0004435 phosphatidylinositol phospholipase C activity 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.621301662710185 GO:0008143 poly(A) binding 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.621301662710185 GO:0008157 protein phosphatase 1 binding 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.621301662710185 GO:0008198 ferrous iron binding 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.621301662710185 GO:0015216 purine nucleotide transmembrane transporter activity 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.621301662710185 GO:0030507 spectrin binding 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.621301662710185 GO:0043548 phosphatidylinositol 3-kinase binding 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.621301662710185 GO:0070412 R-SMAD binding 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.621301662710185 GO:0008238 exopeptidase activity 9/1273 102/18639 0.0882352941176471 1.29192273924495 0.26124955607139 0.621301662710185 GO:0017022 myosin binding 7/1273 76/18639 0.0921052631578947 1.34858601728201 0.26143357868725 0.621301662710185 GO:0022804 active transmembrane transporter activity 35/1273 457/18639 0.0765864332603939 1.12136255266338 0.263295397083555 0.624462214497158 GO:0016758 hexosyltransferase activity 16/1273 197/18639 0.0812182741116751 1.1891809985605 0.271838833730382 0.636866955031562 GO:0008252 nucleotidase activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.636866955031562 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.636866955031562 GO:0030553 cGMP binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.636866955031562 GO:0031005 filamin binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.636866955031562 GO:0033130 acetylcholine receptor binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.636866955031562 GO:0034483 heparan sulfate sulfotransferase activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.636866955031562 GO:0051371 muscle alpha-actinin binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.636866955031562 GO:0120283 protein serine/threonine kinase binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.636866955031562 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/1273 39/18639 0.102564102564103 1.50172215843858 0.275043585801524 0.639408256893047 GO:1990782 protein tyrosine kinase binding 10/1273 117/18639 0.0854700854700855 1.25143513203215 0.277251236524172 0.642185053107609 GO:0019955 cytokine binding 12/1273 144/18639 0.0833333333333333 1.22014925373134 0.279325829271383 0.642185053107609 GO:0004364 glutathione transferase activity 3/1273 27/18639 0.111111111111111 1.62686567164179 0.279520069964215 0.642185053107609 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/1273 27/18639 0.111111111111111 1.62686567164179 0.279520069964215 0.642185053107609 GO:0005385 zinc ion transmembrane transporter activity 3/1273 27/18639 0.111111111111111 1.62686567164179 0.279520069964215 0.642185053107609 GO:0008395 steroid hydroxylase activity 3/1273 27/18639 0.111111111111111 1.62686567164179 0.279520069964215 0.642185053107609 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 5/1273 52/18639 0.0961538461538462 1.40786452353617 0.281008711946859 0.6443441949719 GO:0016757 glycosyltransferase activity 21/1273 267/18639 0.0786516853932584 1.15160154284756 0.281974989689375 0.64529948907471 GO:0022853 active monoatomic ion transmembrane transporter activity 10/1273 118/18639 0.0847457627118644 1.2408297495573 0.286039638505744 0.648531723507926 GO:0008194 UDP-glycosyltransferase activity 12/1273 145/18639 0.0827586206896552 1.21173443129182 0.287245809460662 0.648531723507926 GO:0004532 RNA exonuclease activity 4/1273 40/18639 0.1 1.46417910447761 0.290634547941476 0.648531723507926 GO:0015144 carbohydrate transmembrane transporter activity 4/1273 40/18639 0.1 1.46417910447761 0.290634547941476 0.648531723507926 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/1273 40/18639 0.1 1.46417910447761 0.290634547941476 0.648531723507926 GO:0061791 GTPase motor activity 4/1273 40/18639 0.1 1.46417910447761 0.290634547941476 0.648531723507926 GO:0071949 FAD binding 4/1273 40/18639 0.1 1.46417910447761 0.290634547941476 0.648531723507926 GO:1990606 membrane scission GTPase motor activity 4/1273 40/18639 0.1 1.46417910447761 0.290634547941476 0.648531723507926 GO:0033293 monocarboxylic acid binding 7/1273 79/18639 0.0886075949367089 1.29737389004345 0.293948362185929 0.648531723507926 GO:0008146 sulfotransferase activity 5/1273 53/18639 0.0943396226415094 1.38130104196001 0.294509205516991 0.648531723507926 GO:1901505 carbohydrate derivative transmembrane transporter activity 5/1273 53/18639 0.0943396226415094 1.38130104196001 0.294509205516991 0.648531723507926 GO:0008235 metalloexopeptidase activity 6/1273 66/18639 0.0909090909090909 1.33107191316147 0.295091653491148 0.648531723507926 GO:0061630 ubiquitin protein ligase activity 27/1273 353/18639 0.0764872521246459 1.11991036319817 0.297694565805941 0.648531723507926 GO:0046625 sphingolipid binding 3/1273 28/18639 0.107142857142857 1.56876332622601 0.298606991633709 0.648531723507926 GO:0046966 nuclear thyroid hormone receptor binding 3/1273 28/18639 0.107142857142857 1.56876332622601 0.298606991633709 0.648531723507926 GO:0051019 mitogen-activated protein kinase binding 3/1273 28/18639 0.107142857142857 1.56876332622601 0.298606991633709 0.648531723507926 GO:0051393 alpha-actinin binding 3/1273 28/18639 0.107142857142857 1.56876332622601 0.298606991633709 0.648531723507926 GO:0051959 dynein light intermediate chain binding 3/1273 28/18639 0.107142857142857 1.56876332622601 0.298606991633709 0.648531723507926 GO:0000062 fatty-acyl-CoA binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0004707 MAP kinase activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0005024 transforming growth factor beta receptor activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0008142 oxysterol binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0008296 3'-5'-DNA exonuclease activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0015562 efflux transmembrane transporter activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0022858 alanine transmembrane transporter activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.648531723507926 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 19/1273 243/18639 0.0781893004115226 1.14483139856274 0.303449249955398 0.654957578414724 GO:0032182 ubiquitin-like protein binding 10/1273 120/18639 0.0833333333333333 1.22014925373134 0.303841451339483 0.654957578414724 GO:0050661 NADP binding 5/1273 54/18639 0.0925925925925926 1.35572139303483 0.308115542989918 0.654957578414724 GO:0140463 chromatin-protein adaptor activity 5/1273 54/18639 0.0925925925925926 1.35572139303483 0.308115542989918 0.654957578414724 GO:0051082 unfolded protein binding 10/1273 121/18639 0.0826446280991736 1.21006537560133 0.312843698163577 0.654957578414724 GO:0004676 3-phosphoinositide-dependent protein kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0004711 ribosomal protein S6 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0035175 histone H3S10 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0035979 histone H2AXS139 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0044022 histone H3S28 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0044023 histone H4S1 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0044024 histone H2AS1 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0044025 histone H2BS14 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0072354 histone H3T3 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0072371 histone H2AS121 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0072518 Rho-dependent protein serine/threonine kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0140823 histone H2BS36 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0140855 histone H3S57 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0140995 histone H2A kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0140997 histone H4 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0140998 histone H2B kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:1990244 histone H2AT120 kinase activity 19/1273 245/18639 0.0775510204081633 1.13548583612549 0.316037274166781 0.654957578414724 GO:0004843 cysteine-type deubiquitinase activity 9/1273 108/18639 0.0833333333333333 1.22014925373134 0.317701636320478 0.654957578414724 GO:0106222 lncRNA binding 3/1273 29/18639 0.103448275862069 1.51466803911477 0.317759471025094 0.654957578414724 GO:0003777 microtubule motor activity 6/1273 68/18639 0.0882352941176471 1.29192273924495 0.319452773970143 0.654957578414724 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 6/1273 68/18639 0.0882352941176471 1.29192273924495 0.319452773970143 0.654957578414724 GO:0008307 structural constituent of muscle 4/1273 42/18639 0.0952380952380952 1.39445628997868 0.322128375115932 0.654957578414724 GO:0016859 cis-trans isomerase activity 4/1273 42/18639 0.0952380952380952 1.39445628997868 0.322128375115932 0.654957578414724 GO:0042056 chemoattractant activity 4/1273 42/18639 0.0952380952380952 1.39445628997868 0.322128375115932 0.654957578414724 GO:0043175 RNA polymerase core enzyme binding 4/1273 42/18639 0.0952380952380952 1.39445628997868 0.322128375115932 0.654957578414724 GO:0051879 Hsp90 protein binding 4/1273 42/18639 0.0952380952380952 1.39445628997868 0.322128375115932 0.654957578414724 GO:0004677 DNA-dependent protein kinase activity 19/1273 246/18639 0.0772357723577236 1.13087004004368 0.322386332819704 0.654957578414724 GO:0140857 histone H3T45 kinase activity 19/1273 246/18639 0.0772357723577236 1.13087004004368 0.322386332819704 0.654957578414724 GO:0008429 phosphatidylethanolamine binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.654957578414724 GO:0015278 intracellularly gated calcium channel activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.654957578414724 GO:0016018 cyclosporin A binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.654957578414724 GO:0030548 acetylcholine receptor regulator activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.654957578414724 GO:0070403 NAD+ binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.654957578414724 GO:0070492 oligosaccharide binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.654957578414724 GO:1901567 fatty acid derivative binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.654957578414724 GO:1990226 histone methyltransferase binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.654957578414724 GO:0004620 phospholipase activity 9/1273 109/18639 0.0825688073394495 1.2089552238806 0.327362598513835 0.658088511395963 GO:0002039 p53 binding 6/1273 69/18639 0.0869565217391304 1.27319922128488 0.331745332391152 0.665759008935407 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.671565504047577 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.671565504047577 GO:0008187 poly-pyrimidine tract binding 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.671565504047577 GO:0015215 nucleotide transmembrane transporter activity 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.671565504047577 GO:0048156 tau protein binding 4/1273 43/18639 0.0930232558139535 1.36202707393266 0.337971392637352 0.672505788061444 GO:0016853 isomerase activity 14/1273 180/18639 0.0777777777777778 1.13880597014925 0.346591825103805 0.686454039336083 GO:0015932 nucleobase-containing compound transmembrane transporter activity 5/1273 57/18639 0.087719298245614 1.28436763550668 0.349372439213842 0.686454039336083 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.686454039336083 GO:0008525 phosphatidylcholine transporter activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.686454039336083 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.686454039336083 GO:0016854 racemase and epimerase activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.686454039336083 GO:0017128 phospholipid scramblase activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.686454039336083 GO:0022851 GABA-gated chloride ion channel activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.686454039336083 GO:0035615 clathrin adaptor activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.686454039336083 GO:0099602 neurotransmitter receptor regulator activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.686454039336083 GO:0030020 extracellular matrix structural constituent conferring tensile strength 4/1273 44/18639 0.0909090909090909 1.33107191316147 0.353840416187479 0.691195754748919 GO:0016411 acylglycerol O-acyltransferase activity 3/1273 31/18639 0.0967741935483871 1.41694752046221 0.356061715677821 0.693227950589986 GO:0047499 calcium-independent phospholipase A2 activity 3/1273 31/18639 0.0967741935483871 1.41694752046221 0.356061715677821 0.693227950589986 GO:0008408 3'-5' exonuclease activity 5/1273 58/18639 0.0862068965517241 1.26222336592898 0.363207187919533 0.705968938108496 GO:0042605 peptide antigen binding 4/1273 45/18639 0.0888888888888889 1.30149253731343 0.369708378187884 0.715053766050371 GO:0046915 transition metal ion transmembrane transporter activity 4/1273 45/18639 0.0888888888888889 1.30149253731343 0.369708378187884 0.715053766050371 GO:0140303 intramembrane lipid transporter activity 4/1273 45/18639 0.0888888888888889 1.30149253731343 0.369708378187884 0.715053766050371 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.71672193525206 GO:0043425 bHLH transcription factor binding 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.71672193525206 GO:0070717 poly-purine tract binding 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.71672193525206 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.71672193525206 GO:0004890 GABA-A receptor activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.71672193525206 GO:0008574 plus-end-directed microtubule motor activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.71672193525206 GO:0015245 fatty acid transmembrane transporter activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.71672193525206 GO:0022821 solute:potassium antiporter activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.71672193525206 GO:0120227 acyl-CoA binding 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.71672193525206 GO:0020037 heme binding 11/1273 142/18639 0.0774647887323944 1.13422324994745 0.377678875054362 0.718630468904086 GO:0008514 organic anion transmembrane transporter activity 20/1273 269/18639 0.0743494423791822 1.08860899961161 0.379822424140671 0.721539685988912 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/1273 46/18639 0.0869565217391304 1.27319922128488 0.385549458355277 0.730774510523647 GO:0101005 deubiquitinase activity 9/1273 115/18639 0.0782608695652174 1.14587929915639 0.38622722449586 0.730774510523647 GO:0035591 signaling adaptor activity 10/1273 129/18639 0.0775193798449612 1.13502256161055 0.386551082653479 0.730774510523647 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/1273 60/18639 0.0833333333333333 1.22014925373134 0.390891528963105 0.737792049843545 GO:0019239 deaminase activity 3/1273 33/18639 0.0909090909090909 1.33107191316147 0.394061785926654 0.742581920831287 GO:0009055 electron transfer activity 9/1273 116/18639 0.0775862068965517 1.13600102933608 0.396125711818241 0.743173705072084 GO:0000339 RNA cap binding 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.743173705072084 GO:0001972 retinoic acid binding 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.743173705072084 GO:0016004 phospholipase activator activity 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.743173705072084 GO:0016408 C-acyltransferase activity 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.743173705072084 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.743173705072084 GO:0042288 MHC class I protein binding 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.743173705072084 GO:0052745 inositol phosphate phosphatase activity 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.743173705072084 GO:0043495 protein-membrane adaptor activity 4/1273 47/18639 0.0851063829787234 1.24610987615116 0.401339121819166 0.743173705072084 GO:0061749 forked DNA-dependent helicase activity 4/1273 47/18639 0.0851063829787234 1.24610987615116 0.401339121819166 0.743173705072084 GO:1990518 single-stranded 3'-5' DNA helicase activity 4/1273 47/18639 0.0851063829787234 1.24610987615116 0.401339121819166 0.743173705072084 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/1273 61/18639 0.0819672131147541 1.20014680694886 0.404706903252042 0.748229770736846 GO:0005253 monoatomic anion channel activity 8/1273 103/18639 0.0776699029126214 1.13722648891465 0.406559571971771 0.750473172161729 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/1273 34/18639 0.0882352941176471 1.29192273924495 0.412849053969084 0.757319983374539 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/1273 34/18639 0.0882352941176471 1.29192273924495 0.412849053969084 0.757319983374539 GO:0030332 cyclin binding 3/1273 34/18639 0.0882352941176471 1.29192273924495 0.412849053969084 0.757319983374539 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/1273 34/18639 0.0882352941176471 1.29192273924495 0.412849053969084 0.757319983374539 GO:0005179 hormone activity 10/1273 132/18639 0.0757575757575758 1.10922659430122 0.414597784373262 0.759341339866161 GO:0009378 four-way junction helicase activity 4/1273 48/18639 0.0833333333333333 1.22014925373134 0.417054145862613 0.760281936712278 GO:0036121 double-stranded DNA helicase activity 4/1273 48/18639 0.0833333333333333 1.22014925373134 0.417054145862613 0.760281936712278 GO:0043138 3'-5' DNA helicase activity 4/1273 48/18639 0.0833333333333333 1.22014925373134 0.417054145862613 0.760281936712278 GO:0015179 L-amino acid transmembrane transporter activity 5/1273 62/18639 0.0806451612903226 1.18078960038517 0.418482668839175 0.760677197237884 GO:0005126 cytokine receptor binding 20/1273 275/18639 0.0727272727272727 1.06485753052917 0.418566839365991 0.760677197237884 GO:0015085 calcium ion transmembrane transporter activity 11/1273 147/18639 0.0748299319727891 1.09564422784039 0.42204574995161 0.765674163194523 GO:0005123 death receptor binding 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.765674163194523 GO:0005248 voltage-gated sodium channel activity 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.765674163194523 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.765674163194523 GO:0051010 microtubule plus-end binding 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.765674163194523 GO:0070182 DNA polymerase binding 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.765674163194523 GO:0004252 serine-type endopeptidase activity 13/1273 176/18639 0.0738636363636364 1.08149592944369 0.426374970466052 0.766560819796547 GO:0004623 phospholipase A2 activity 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.771457939472235 GO:0016229 steroid dehydrogenase activity 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.771457939472235 GO:0034061 DNA polymerase activity 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.771457939472235 GO:0001222 transcription corepressor binding 4/1273 49/18639 0.0816326530612245 1.19524824855315 0.432672636328212 0.771457939472235 GO:0060590 ATPase regulator activity 4/1273 49/18639 0.0816326530612245 1.19524824855315 0.432672636328212 0.771457939472235 GO:0019787 ubiquitin-like protein transferase activity 34/1273 479/18639 0.0709812108559499 1.03929205745801 0.433041552054687 0.771457939472235 GO:0016755 aminoacyltransferase activity 35/1273 496/18639 0.0705645161290323 1.03319090033702 0.445549056157606 0.777757563813329 GO:0015605 organophosphate ester transmembrane transporter activity 4/1273 50/18639 0.08 1.17134328358209 0.448174034689156 0.777757563813329 GO:0005243 gap junction channel activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0008649 rRNA methyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0032931 histone H3K56 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0043992 histone H3K9 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0043993 histone H3K18 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0043994 histone H3K23 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0043999 histone H2AK5 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0044012 histone H2AK9 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0044014 histone H2BK5 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0044015 histone H2BK12 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0044016 histone H3K4 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0044017 histone H3K27 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0044018 histone H3K36 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0046972 histone H4K16 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0070034 telomerase RNA binding 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0140908 histone H3K122 acetyltransferase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.777757563813329 GO:0004190 aspartic-type endopeptidase activity 3/1273 36/18639 0.0833333333333333 1.22014925373134 0.449827415527471 0.777757563813329 GO:0016409 palmitoyltransferase activity 3/1273 36/18639 0.0833333333333333 1.22014925373134 0.449827415527471 0.777757563813329 GO:0016922 nuclear receptor binding 10/1273 137/18639 0.072992700729927 1.06874387188147 0.461262688643196 0.784866837831683 GO:0042562 hormone binding 7/1273 94/18639 0.074468085106383 1.09034614163226 0.463314757933882 0.784866837831683 GO:0003743 translation initiation factor activity 4/1273 51/18639 0.0784313725490196 1.14837576821773 0.463539116739026 0.784866837831683 GO:0016830 carbon-carbon lyase activity 4/1273 51/18639 0.0784313725490196 1.14837576821773 0.463539116739026 0.784866837831683 GO:0022829 wide pore channel activity 3/1273 37/18639 0.0810810810810811 1.18717224687374 0.467959496193981 0.784866837831683 GO:0030551 cyclic nucleotide binding 3/1273 37/18639 0.0810810810810811 1.18717224687374 0.467959496193981 0.784866837831683 GO:0042805 actinin binding 3/1273 37/18639 0.0810810810810811 1.18717224687374 0.467959496193981 0.784866837831683 GO:0004602 glutathione peroxidase activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.784866837831683 GO:0016917 GABA receptor activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.784866837831683 GO:0044013 histone H2B acetyltransferase activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.784866837831683 GO:0099186 structural constituent of postsynapse 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.784866837831683 GO:0140102 catalytic activity, acting on a rRNA 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.784866837831683 GO:0140103 catalytic activity, acting on a glycoprotein 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.784866837831683 GO:0015101 organic cation transmembrane transporter activity 6/1273 81/18639 0.0740740740740741 1.08457711442786 0.479960662620512 0.784866837831683 GO:0005501 retinoid binding 3/1273 38/18639 0.0789473684210526 1.15593087195601 0.485819040049698 0.784866837831683 GO:0019840 isoprenoid binding 3/1273 38/18639 0.0789473684210526 1.15593087195601 0.485819040049698 0.784866837831683 GO:0043531 ADP binding 3/1273 38/18639 0.0789473684210526 1.15593087195601 0.485819040049698 0.784866837831683 GO:0008173 RNA methyltransferase activity 5/1273 67/18639 0.0746268656716418 1.09267097349076 0.486250434175002 0.784866837831683 GO:0005246 calcium channel regulator activity 4/1273 53/18639 0.0754716981132075 1.10504083356801 0.493790047338758 0.784866837831683 GO:0016860 intramolecular oxidoreductase activity 4/1273 53/18639 0.0754716981132075 1.10504083356801 0.493790047338758 0.784866837831683 GO:0017046 peptide hormone binding 4/1273 53/18639 0.0754716981132075 1.10504083356801 0.493790047338758 0.784866837831683 GO:0015295 solute:proton symporter activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.784866837831683 GO:0030552 cAMP binding 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.784866837831683 GO:0043998 histone H2A acetyltransferase activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.784866837831683 GO:0060229 lipase activator activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.784866837831683 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.784866837831683 GO:0070840 dynein complex binding 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.784866837831683 GO:0003924 GTPase activity 23/1273 331/18639 0.0694864048338369 1.01740542002976 0.497096757975412 0.784866837831683 GO:0005254 chloride channel activity 6/1273 83/18639 0.072289156626506 1.05844272612839 0.503973148348105 0.784866837831683 GO:0008135 translation factor activity, RNA binding 6/1273 83/18639 0.072289156626506 1.05844272612839 0.503973148348105 0.784866837831683 GO:0019783 ubiquitin-like protein peptidase activity 9/1273 127/18639 0.0708661417322835 1.03760723939358 0.504190741166249 0.784866837831683 GO:0042826 histone deacetylase binding 9/1273 127/18639 0.0708661417322835 1.03760723939358 0.504190741166249 0.784866837831683 GO:0022836 gated channel activity 22/1273 318/18639 0.0691823899371069 1.01295409743734 0.507057452908562 0.784866837831683 GO:0000182 rDNA binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0004955 prostaglandin receptor activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0005031 tumor necrosis factor receptor activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0005337 nucleoside transmembrane transporter activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0005381 iron ion transmembrane transporter activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0005528 FK506 binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0008239 dipeptidyl-peptidase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0015643 toxic substance binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0032052 bile acid binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0043121 neurotrophin binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0043295 glutathione binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0043422 protein kinase B binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0045322 unmethylated CpG binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0051378 serotonin binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0051880 G-quadruplex DNA binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0098505 G-rich strand telomeric DNA binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0099122 RNA polymerase II C-terminal domain binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0140999 histone H3K4 trimethyltransferase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:1990763 arrestin family protein binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.784866837831683 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/1273 54/18639 0.0740740740740741 1.08457711442786 0.508644007686666 0.784866837831683 GO:0051117 ATPase binding 6/1273 84/18639 0.0714285714285714 1.04584221748401 0.515830234996506 0.784866837831683 GO:0180051 translation factor activity 6/1273 84/18639 0.0714285714285714 1.04584221748401 0.515830234996506 0.784866837831683 GO:0003707 nuclear steroid receptor activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.784866837831683 GO:0005537 D-mannose binding 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.784866837831683 GO:0015645 fatty acid ligase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.784866837831683 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.784866837831683 GO:0019211 phosphatase activator activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.784866837831683 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.784866837831683 GO:0019707 protein-cysteine S-acyltransferase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.784866837831683 GO:0047617 fatty acyl-CoA hydrolase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.784866837831683 GO:0120515 fatty acid-CoA ligase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.784866837831683 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/1273 40/18639 0.075 1.09813432835821 0.520633589342093 0.784866837831683 GO:0022834 ligand-gated channel activity 13/1273 188/18639 0.0691489361702128 1.01246427437282 0.5229630913081 0.784866837831683 GO:0016782 transferase activity, transferring sulphur-containing groups 5/1273 70/18639 0.0714285714285714 1.04584221748401 0.525554746759389 0.784866837831683 GO:0043130 ubiquitin binding 7/1273 100/18639 0.07 1.02492537313433 0.52943738484255 0.784866837831683 GO:0016298 lipase activity 9/1273 130/18639 0.0692307692307692 1.01366245694604 0.532815632022898 0.784866837831683 GO:0042277 peptide binding 17/1273 249/18639 0.0682730923694779 0.999640352454594 0.53692397169291 0.784866837831683 GO:0001530 lipopolysaccharide binding 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.784866837831683 GO:0001727 lipid kinase activity 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.784866837831683 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.784866837831683 GO:0016877 ligase activity, forming carbon-sulfur bonds 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.784866837831683 GO:0017080 sodium channel regulator activity 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.784866837831683 GO:0042287 MHC protein binding 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.784866837831683 GO:0140828 metal cation:monoatomic cation antiporter activity 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.784866837831683 GO:0170055 lipid transmembrane transporter activity 4/1273 56/18639 0.0714285714285714 1.04584221748401 0.537738702521115 0.784866837831683 GO:0001637 G protein-coupled chemoattractant receptor activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0004529 DNA exonuclease activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0004950 chemokine receptor activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0005112 Notch binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0005227 calcium-activated cation channel activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0016289 acyl-CoA hydrolase activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0019865 immunoglobulin binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0030247 polysaccharide binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0051139 metal cation:proton antiporter activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0052742 phosphatidylinositol kinase activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.784866837831683 GO:0050660 flavin adenine dinucleotide binding 6/1273 86/18639 0.0697674418604651 1.0215203054495 0.539205418708581 0.784866837831683 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0001851 complement component C3b binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0004954 prostanoid receptor activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0008503 benzodiazepine receptor activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0010854 adenylate cyclase regulator activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0019864 IgG binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0032050 clathrin heavy chain binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0034056 estrogen response element binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0034713 type I transforming growth factor beta receptor binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0035252 UDP-xylosyltransferase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0042285 xylosyltransferase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0043522 leucine zipper domain binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0045294 alpha-catenin binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0050998 nitric-oxide synthase binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0070697 activin receptor binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0140031 phosphorylation-dependent protein binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0140537 transcription regulator activator activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0180030 inositol phosphate kinase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:1900750 oligopeptide binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:1990948 ubiquitin ligase inhibitor activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.784866837831683 GO:0005262 calcium channel activity 9/1273 131/18639 0.0687022900763359 1.00592457559531 0.542226766895664 0.785894104117912 GO:0016504 peptidase activator activity 4/1273 57/18639 0.0701754385964912 1.02749410840534 0.551955024280155 0.793145650679736 GO:0019001 guanyl nucleotide binding 27/1273 400/18639 0.0675 0.988320895522388 0.5544738709481 0.793145650679736 GO:0032561 guanyl ribonucleotide binding 27/1273 400/18639 0.0675 0.988320895522388 0.5544738709481 0.793145650679736 GO:0001671 ATPase activator activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.793145650679736 GO:0008266 poly(U) RNA binding 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.793145650679736 GO:0008320 protein transmembrane transporter activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.793145650679736 GO:0016405 CoA-ligase activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.793145650679736 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.793145650679736 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.793145650679736 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.793145650679736 GO:0017116 single-stranded DNA helicase activity 4/1273 58/18639 0.0689655172413793 1.00977869274318 0.565936345492053 0.793145650679736 GO:0015081 sodium ion transmembrane transporter activity 11/1273 164/18639 0.0670731707317073 0.982071350564252 0.569461614216922 0.793145650679736 GO:0008236 serine-type peptidase activity 13/1273 194/18639 0.0670103092783505 0.981150946299431 0.569548112739415 0.793145650679736 GO:0005245 voltage-gated calcium channel activity 3/1273 43/18639 0.0697674418604651 1.0215203054495 0.570333882352448 0.793145650679736 GO:0000340 RNA 7-methylguanosine cap binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0004126 cytidine deaminase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0004875 complement receptor activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0005078 MAP-kinase scaffold activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0005527 macrolide binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0010853 cyclase activator activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0015132 prostaglandin transmembrane transporter activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0015368 calcium:monoatomic cation antiporter activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0016423 tRNA (guanine) methyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0016801 hydrolase activity, acting on ether bonds 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0016803 ether hydrolase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0035251 UDP-glucosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0035497 cAMP response element binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0043047 single-stranded telomeric DNA binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0070410 co-SMAD binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0097371 MDM2/MDM4 family protein binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:1990459 transferrin receptor binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:1990817 poly(A) RNA polymerase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.793145650679736 GO:0003678 DNA helicase activity 5/1273 74/18639 0.0675675675675676 0.989310205728116 0.575781955811151 0.795019275017815 GO:0035064 methylated histone binding 5/1273 74/18639 0.0675675675675676 0.989310205728116 0.575781955811151 0.795019275017815 GO:0004842 ubiquitin-protein transferase activity 30/1273 449/18639 0.066815144766147 0.978293388292391 0.577608414910075 0.795019275017815 GO:0005242 inward rectifier potassium channel activity 2/1273 28/18639 0.0714285714285714 1.04584221748401 0.579052934948466 0.795019275017815 GO:0036408 histone H3K14 acetyltransferase activity 2/1273 28/18639 0.0714285714285714 1.04584221748401 0.579052934948466 0.795019275017815 GO:0050698 proteoglycan sulfotransferase activity 2/1273 28/18639 0.0714285714285714 1.04584221748401 0.579052934948466 0.795019275017815 GO:0015297 antiporter activity 9/1273 135/18639 0.0666666666666667 0.976119402985075 0.579107482491224 0.795019275017815 GO:0036002 pre-mRNA binding 4/1273 59/18639 0.0677966101694915 0.992663799645839 0.579673338513842 0.795019275017815 GO:0070063 RNA polymerase binding 4/1273 59/18639 0.0677966101694915 0.992663799645839 0.579673338513842 0.795019275017815 GO:0043014 alpha-tubulin binding 3/1273 44/18639 0.0681818181818182 0.998303934871099 0.586174867681593 0.797871107443876 GO:0003697 single-stranded DNA binding 8/1273 121/18639 0.0661157024793388 0.968052300481066 0.589837447826642 0.797871107443876 GO:0015291 secondary active transmembrane transporter activity 19/1273 287/18639 0.0662020905923345 0.969317177180301 0.590379612795978 0.797871107443876 GO:0004497 monooxygenase activity 7/1273 106/18639 0.0660377358490566 0.966910729372008 0.592158669245003 0.797871107443876 GO:0008013 beta-catenin binding 7/1273 106/18639 0.0660377358490566 0.966910729372008 0.592158669245003 0.797871107443876 GO:0001098 basal transcription machinery binding 4/1273 60/18639 0.0666666666666667 0.976119402985075 0.593157753481751 0.797871107443876 GO:0001099 basal RNA polymerase II transcription machinery binding 4/1273 60/18639 0.0666666666666667 0.976119402985075 0.593157753481751 0.797871107443876 GO:0005525 GTP binding 25/1273 378/18639 0.0661375661375661 0.968372423596304 0.596558562436 0.797871107443876 GO:0010484 histone H3 acetyltransferase activity 2/1273 29/18639 0.0689655172413793 1.00977869274318 0.598408006350198 0.797871107443876 GO:0016417 S-acyltransferase activity 2/1273 29/18639 0.0689655172413793 1.00977869274318 0.598408006350198 0.797871107443876 GO:0043236 laminin binding 2/1273 29/18639 0.0689655172413793 1.00977869274318 0.598408006350198 0.797871107443876 GO:0099604 ligand-gated calcium channel activity 2/1273 29/18639 0.0689655172413793 1.00977869274318 0.598408006350198 0.797871107443876 GO:0017171 serine hydrolase activity 13/1273 198/18639 0.0656565656565657 0.961329715061058 0.59958608933043 0.797871107443876 GO:0140034 methylation-dependent protein binding 5/1273 76/18639 0.0657894736842105 0.963275726630008 0.599814618901421 0.797871107443876 GO:0004535 poly(A)-specific ribonuclease activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0004993 G protein-coupled serotonin receptor activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0005172 vascular endothelial growth factor receptor binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0035673 oligopeptide transmembrane transporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0046975 histone H3K36 methyltransferase activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0061459 L-arginine transmembrane transporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0070123 transforming growth factor beta receptor activity, type III 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0070700 BMP receptor binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0071714 icosanoid transmembrane transporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0097157 pre-mRNA intronic binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0140666 annealing activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.797871107443876 GO:0052689 carboxylic ester hydrolase activity 6/1273 92/18639 0.0652173913043478 0.95489941596366 0.606123670115647 0.803148068527956 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/1273 46/18639 0.0652173913043478 0.95489941596366 0.616712618027798 0.807542251990414 GO:0030276 clathrin binding 3/1273 46/18639 0.0652173913043478 0.95489941596366 0.616712618027798 0.807542251990414 GO:0022839 monoatomic ion-gated channel activity 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.807542251990414 GO:0033612 receptor serine/threonine kinase binding 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.807542251990414 GO:0043995 histone H4K5 acetyltransferase activity 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.807542251990414 GO:0043996 histone H4K8 acetyltransferase activity 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.807542251990414 GO:0043997 histone H4K12 acetyltransferase activity 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.807542251990414 GO:0048019 receptor antagonist activity 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.807542251990414 GO:0098918 structural constituent of synapse 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.807542251990414 GO:0015276 ligand-gated monoatomic ion channel activity 12/1273 186/18639 0.0645161290322581 0.944631680308137 0.623387059198213 0.807542251990414 GO:0008174 mRNA methyltransferase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0008195 phosphatidate phosphatase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0008331 high voltage-gated calcium channel activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0008494 translation activator activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0015386 potassium:proton antiporter activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0030983 mismatched DNA binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0032036 myosin heavy chain binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0042813 Wnt receptor activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0043176 amine binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0046030 inositol trisphosphate phosphatase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0070742 C2H2 zinc finger domain binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0071933 Arp2/3 complex binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0098847 sequence-specific single stranded DNA binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:1901474 azole transmembrane transporter activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:1990825 sequence-specific mRNA binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.807542251990414 GO:0099095 ligand-gated monoatomic anion channel activity 3/1273 47/18639 0.0638297872340425 0.934582407113369 0.631397174587478 0.810044967671474 GO:1901682 sulfur compound transmembrane transporter activity 4/1273 63/18639 0.0634920634920635 0.929637526652452 0.632028271198527 0.810044967671474 GO:0005164 tumor necrosis factor receptor binding 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.810426053465598 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.810426053465598 GO:0016878 acid-thiol ligase activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.810426053465598 GO:0017147 Wnt-protein binding 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.810426053465598 GO:0046943 carboxylic acid transmembrane transporter activity 12/1273 188/18639 0.0638297872340425 0.934582407113369 0.638169350532235 0.813028240982365 GO:0005125 cytokine activity 15/1273 234/18639 0.0641025641025641 0.93857634902411 0.638511105780017 0.813028240982365 GO:0005342 organic acid transmembrane transporter activity 12/1273 189/18639 0.0634920634920635 0.929637526652452 0.645446143562838 0.817771438418733 GO:0001664 G protein-coupled receptor binding 19/1273 297/18639 0.063973063973064 0.936680235187698 0.650400674717722 0.817771438418733 GO:0022884 macromolecule transmembrane transporter activity 2/1273 32/18639 0.0625 0.915111940298508 0.652417964195288 0.817771438418733 GO:0047498 calcium-dependent phospholipase A2 activity 2/1273 32/18639 0.0625 0.915111940298508 0.652417964195288 0.817771438418733 GO:0000774 adenyl-nucleotide exchange factor activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0004129 cytochrome-c oxidase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0004559 alpha-mannosidase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0004953 icosanoid receptor activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0015929 hexosaminidase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0031386 protein tag activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0042809 nuclear vitamin D receptor binding 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0048531 beta-1,3-galactosyltransferase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0140776 protein-containing complex destabilizing activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0141047 molecular tag activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.817771438418733 GO:0160215 deacylase activity 4/1273 65/18639 0.0615384615384615 0.901033295063146 0.656572256449826 0.8200168394384 GO:0015079 potassium ion transmembrane transporter activity 10/1273 160/18639 0.0625 0.915111940298508 0.660029427132132 0.82345860515741 GO:0048020 CCR chemokine receptor binding 3/1273 50/18639 0.06 0.878507462686567 0.673072861638011 0.833137444793141 GO:0004708 MAP kinase kinase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0005149 interleukin-1 receptor binding 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0015378 sodium:chloride symporter activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0015385 sodium:proton antiporter activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0015923 mannosidase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0016722 oxidoreductase activity, acting on metal ions 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0019841 retinol binding 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0022841 potassium ion leak channel activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0030275 LRR domain binding 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0140328 floppase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.833137444793141 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/1273 67/18639 0.0597014925373134 0.874136778792604 0.679989170170389 0.835049462113009 GO:0008175 tRNA methyltransferase activity 2/1273 34/18639 0.0588235294117647 0.861281826163301 0.685100920401227 0.838694974505778 GO:0016831 carboxy-lyase activity 2/1273 34/18639 0.0588235294117647 0.861281826163301 0.685100920401227 0.838694974505778 GO:0051427 hormone receptor binding 2/1273 34/18639 0.0588235294117647 0.861281826163301 0.685100920401227 0.838694974505778 GO:0030544 Hsp70 protein binding 3/1273 51/18639 0.0588235294117647 0.861281826163301 0.686168720694197 0.839127164682279 GO:0004527 exonuclease activity 5/1273 84/18639 0.0595238095238095 0.871535181236674 0.687722244481342 0.840151836650463 GO:0008509 monoatomic anion transmembrane transporter activity 9/1273 149/18639 0.0604026845637584 0.884403485926074 0.69601580800846 0.843442333345638 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0004659 prenyltransferase activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0008569 minus-end-directed microtubule motor activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0016805 dipeptidase activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0045236 CXCR chemokine receptor binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0070402 NADPH binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.843442333345638 GO:0010485 histone H4 acetyltransferase activity 2/1273 35/18639 0.0571428571428571 0.836673773987207 0.700473828800679 0.843442333345638 GO:0061631 ubiquitin conjugating enzyme activity 2/1273 35/18639 0.0571428571428571 0.836673773987207 0.700473828800679 0.843442333345638 GO:0015171 amino acid transmembrane transporter activity 6/1273 102/18639 0.0588235294117647 0.861281826163301 0.704648042814625 0.84759918264792 GO:0051018 protein kinase A binding 3/1273 53/18639 0.0566037735849057 0.828780625176007 0.711172493816085 0.850709669363198 GO:0008028 monocarboxylic acid transmembrane transporter activity 4/1273 70/18639 0.0571428571428571 0.836673773987207 0.712975764601121 0.850709669363198 GO:0005484 SNAP receptor activity 2/1273 36/18639 0.0555555555555556 0.813432835820896 0.715217735463809 0.850709669363198 GO:0055106 ubiquitin-protein transferase regulator activity 2/1273 36/18639 0.0555555555555556 0.813432835820896 0.715217735463809 0.850709669363198 GO:0005216 monoatomic ion channel activity 28/1273 448/18639 0.0625 0.915111940298508 0.71563605040324 0.850709669363198 GO:0000400 four-way junction DNA binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0000900 mRNA regulatory element binding translation repressor activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0004970 glutamate-gated receptor activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0008308 voltage-gated monoatomic anion channel activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0015172 acidic amino acid transmembrane transporter activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0015373 monoatomic anion:sodium symporter activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0030228 lipoprotein particle receptor activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0031690 adrenergic receptor binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0050811 GABA receptor binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0070628 proteasome binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:1990381 ubiquitin-specific protease binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.850709669363198 GO:0015078 proton transmembrane transporter activity 11/1273 185/18639 0.0594594594594595 0.870592981040742 0.725585805960255 0.855227263463497 GO:0015108 chloride transmembrane transporter activity 7/1273 121/18639 0.0578512396694215 0.847045762920933 0.727769608710465 0.855227263463497 GO:0019213 deacetylase activity 2/1273 37/18639 0.0540540540540541 0.791448164582493 0.729346777707799 0.855227263463497 GO:0030280 structural constituent of skin epidermis 2/1273 37/18639 0.0540540540540541 0.791448164582493 0.729346777707799 0.855227263463497 GO:0042379 chemokine receptor binding 4/1273 72/18639 0.0555555555555556 0.813432835820896 0.733541068211592 0.855227263463497 GO:0008374 O-acyltransferase activity 3/1273 55/18639 0.0545454545454545 0.798643147896879 0.734612171083493 0.855227263463497 GO:0000149 SNARE binding 6/1273 106/18639 0.0566037735849057 0.828780625176007 0.739006286361256 0.855227263463497 GO:0003756 protein disulfide isomerase activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0016918 retinal binding 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0022840 leak channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0022842 narrow pore channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0042577 lipid phosphatase activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0042800 histone H3K4 methyltransferase activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0042834 peptidoglycan binding 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0046527 glucosyltransferase activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0099589 serotonin receptor activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0141147 intracellularly calcium-gated channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.855227263463497 GO:0042162 telomeric DNA binding 2/1273 38/18639 0.0526315789473684 0.770620581304006 0.742876096466582 0.857558050395052 GO:0042887 amide transmembrane transporter activity 2/1273 38/18639 0.0526315789473684 0.770620581304006 0.742876096466582 0.857558050395052 GO:0005244 voltage-gated monoatomic ion channel activity 10/1273 173/18639 0.0578034682080925 0.84634630316625 0.751421723139072 0.86560104615713 GO:0000217 DNA secondary structure binding 2/1273 39/18639 0.0512820512820513 0.750861079219288 0.755821633506017 0.86560104615713 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.86560104615713 GO:0010851 cyclase regulator activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.86560104615713 GO:0015095 magnesium ion transmembrane transporter activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.86560104615713 GO:0016505 peptidase activator activity involved in apoptotic process 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.86560104615713 GO:0043024 ribosomal small subunit binding 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.86560104615713 GO:0061608 nuclear import signal receptor activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.86560104615713 GO:0140664 ATP-dependent DNA damage sensor activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.86560104615713 GO:0140939 histone H4 methyltransferase activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.86560104615713 GO:0044183 protein folding chaperone 4/1273 75/18639 0.0533333333333333 0.78089552238806 0.762278030216229 0.870539306881179 GO:0022832 voltage-gated channel activity 10/1273 175/18639 0.0571428571428571 0.836673773987207 0.763854066277837 0.871491422556056 GO:0061980 regulatory RNA binding 3/1273 58/18639 0.0517241379310345 0.757334019557386 0.766918288277764 0.87250302810442 GO:0030331 nuclear estrogen receptor binding 2/1273 40/18639 0.05 0.732089552238806 0.768199951619907 0.87250302810442 GO:0071855 neuropeptide receptor binding 2/1273 40/18639 0.05 0.732089552238806 0.768199951619907 0.87250302810442 GO:0140662 ATP-dependent protein folding chaperone 2/1273 40/18639 0.05 0.732089552238806 0.768199951619907 0.87250302810442 GO:0022843 voltage-gated monoatomic cation channel activity 8/1273 143/18639 0.0559440559440559 0.819121177330132 0.768456670408834 0.87250302810442 GO:0099106 ion channel regulator activity 9/1273 160/18639 0.05625 0.823600746268657 0.772027194941821 0.873519144618654 GO:0001846 opsonin binding 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.873519144618654 GO:0015174 basic amino acid transmembrane transporter activity 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.873519144618654 GO:0035613 RNA stem-loop binding 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.873519144618654 GO:0061891 calcium ion sensor activity 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.873519144618654 GO:0072542 protein phosphatase activator activity 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.873519144618654 GO:0004879 nuclear receptor activity 3/1273 59/18639 0.0508474576271186 0.744497849734379 0.776949267729403 0.875372783411054 GO:0070888 E-box binding 3/1273 59/18639 0.0508474576271186 0.744497849734379 0.776949267729403 0.875372783411054 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/1273 41/18639 0.0487804878048781 0.714233709501274 0.780028075617613 0.877158008405247 GO:0140318 protein transporter activity 2/1273 41/18639 0.0487804878048781 0.714233709501274 0.780028075617613 0.877158008405247 GO:0098531 ligand-modulated transcription factor activity 3/1273 60/18639 0.05 0.732089552238806 0.786622505321384 0.880581625944843 GO:0015293 symporter activity 8/1273 146/18639 0.0547945205479452 0.802289920261705 0.787770925489924 0.880581625944843 GO:0008970 phospholipase A1 activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.880581625944843 GO:0015377 chloride:monoatomic cation symporter activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.880581625944843 GO:0016881 acid-amino acid ligase activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.880581625944843 GO:0050321 tau-protein kinase activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.880581625944843 GO:0061133 endopeptidase activator activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.880581625944843 GO:0140784 metal ion sensor activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.880581625944843 GO:0004402 histone acetyltransferase activity 2/1273 42/18639 0.0476190476190476 0.697228144989339 0.791323352105459 0.880581625944843 GO:0019894 kinesin binding 2/1273 42/18639 0.0476190476190476 0.697228144989339 0.791323352105459 0.880581625944843 GO:0035198 miRNA binding 2/1273 42/18639 0.0476190476190476 0.697228144989339 0.791323352105459 0.880581625944843 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7/1273 130/18639 0.0538461538461538 0.788404133180253 0.792505612326176 0.88106211067323 GO:0019905 syntaxin binding 3/1273 61/18639 0.0491803278688525 0.720088084169317 0.795945270706085 0.884048957245926 GO:0015103 inorganic anion transmembrane transporter activity 9/1273 165/18639 0.0545454545454545 0.798643147896879 0.801704722718956 0.888448056645956 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.888448056645956 GO:0008171 O-methyltransferase activity 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.888448056645956 GO:0016493 C-C chemokine receptor activity 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.888448056645956 GO:0031681 G-protein beta-subunit binding 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.888448056645956 GO:0005249 voltage-gated potassium channel activity 5/1273 98/18639 0.0510204081632653 0.74703015534572 0.807664244058957 0.891163367034976 GO:0008170 N-methyltransferase activity 5/1273 98/18639 0.0510204081632653 0.74703015534572 0.807664244058957 0.891163367034976 GO:0016790 thiolester hydrolase activity 2/1273 44/18639 0.0454545454545455 0.665535956580733 0.812385633790141 0.892364389446852 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 9/1273 167/18639 0.0538922155688623 0.789078559299312 0.812736147594411 0.892364389446852 GO:0022824 transmitter-gated monoatomic ion channel activity 3/1273 63/18639 0.0476190476190476 0.697228144989339 0.813569994099248 0.892364389446852 GO:0022835 transmitter-gated channel activity 3/1273 63/18639 0.0476190476190476 0.697228144989339 0.813569994099248 0.892364389446852 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.892364389446852 GO:0004806 triacylglycerol lipase activity 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.892364389446852 GO:0005315 phosphate transmembrane transporter activity 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.892364389446852 GO:0005540 hyaluronic acid binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.892364389446852 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.892364389446852 GO:0019957 C-C chemokine binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.892364389446852 GO:0140612 DNA damage sensor activity 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.892364389446852 GO:0016247 channel regulator activity 9/1273 168/18639 0.0535714285714286 0.784381663113006 0.818074988565446 0.892583677115087 GO:0008009 chemokine activity 2/1273 45/18639 0.0444444444444444 0.650746268656716 0.82218790699953 0.895406867177595 GO:0051539 4 iron, 4 sulfur cluster binding 2/1273 45/18639 0.0444444444444444 0.650746268656716 0.82218790699953 0.895406867177595 GO:0141108 transporter regulator activity 9/1273 170/18639 0.0529411764705882 0.775153643546971 0.828403677129276 0.897672531810423 GO:0099094 ligand-gated monoatomic cation channel activity 7/1273 136/18639 0.0514705882352941 0.753621597892888 0.828747827287175 0.897672531810423 GO:0001848 complement binding 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.897672531810423 GO:0008139 nuclear localization sequence binding 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.897672531810423 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.897672531810423 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.897672531810423 GO:0017056 structural constituent of nuclear pore 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.897672531810423 GO:0046873 metal ion transmembrane transporter activity 26/1273 450/18639 0.0577777777777778 0.845970149253731 0.839049710487819 0.906104866364033 GO:0061733 protein-lysine-acetyltransferase activity 2/1273 47/18639 0.0425531914893617 0.62305493807558 0.840422382562966 0.906104866364033 GO:0008066 glutamate receptor activity 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.906104866364033 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.906104866364033 GO:0034237 protein kinase A regulatory subunit binding 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.906104866364033 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/1273 48/18639 0.0416666666666667 0.610074626865672 0.848889150942407 0.913470085432068 GO:0023026 MHC class II protein complex binding 1/1273 27/18639 0.037037037037037 0.54228855721393 0.852128668162634 0.916116352035653 GO:0005267 potassium channel activity 6/1273 124/18639 0.0483870967741935 0.708473760231103 0.858146948676507 0.921670260029912 GO:0016279 protein-lysine N-methyltransferase activity 3/1273 69/18639 0.0434782608695652 0.63659961064244 0.858864790862626 0.921670260029912 GO:0008527 taste receptor activity 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.924450040054545 GO:0016278 lysine N-methyltransferase activity 3/1273 70/18639 0.0428571428571429 0.627505330490405 0.865397135322097 0.926985617580421 GO:0004181 metallocarboxypeptidase activity 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.928854955038271 GO:0005416 amino acid:monoatomic cation symporter activity 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.928854955038271 GO:0035250 UDP-galactosyltransferase activity 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.928854955038271 GO:0051861 glycolipid binding 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.928854955038271 GO:0005048 signal sequence binding 2/1273 51/18639 0.0392156862745098 0.574187884108867 0.871889404133028 0.928854955038271 GO:0016597 amino acid binding 2/1273 51/18639 0.0392156862745098 0.574187884108867 0.871889404133028 0.928854955038271 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/1273 91/18639 0.043956043956044 0.64359521075939 0.876536675241395 0.932959253611421 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/1273 30/18639 0.0333333333333333 0.488059701492537 0.880443868856444 0.935421811798612 GO:0051721 protein phosphatase 2A binding 1/1273 30/18639 0.0333333333333333 0.488059701492537 0.880443868856444 0.935421811798612 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 3/1273 73/18639 0.0410958904109589 0.601717440196279 0.883421264422589 0.937736495869909 GO:0034212 protein N-acetyltransferase activity 2/1273 53/18639 0.0377358490566038 0.552520416784005 0.885384297546422 0.938123795414711 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/1273 53/18639 0.0377358490566038 0.552520416784005 0.885384297546422 0.938123795414711 GO:0008327 methyl-CpG binding 1/1273 31/18639 0.032258064516129 0.472315840154068 0.888622435944721 0.939858324143336 GO:0072349 modified amino acid transmembrane transporter activity 1/1273 31/18639 0.032258064516129 0.472315840154068 0.888622435944721 0.939858324143336 GO:0140098 catalytic activity, acting on RNA 21/1273 387/18639 0.0542635658914729 0.794515793127386 0.889451494235403 0.939888437652892 GO:0017069 snRNA binding 2/1273 54/18639 0.037037037037037 0.54228855721393 0.891626542291414 0.941339532958741 GO:0019003 GDP binding 3/1273 75/18639 0.04 0.585671641791045 0.894210259772138 0.942820816961673 GO:0008378 galactosyltransferase activity 1/1273 32/18639 0.03125 0.457555970149254 0.896241935033413 0.942820816961673 GO:0015106 bicarbonate transmembrane transporter activity 1/1273 32/18639 0.03125 0.457555970149254 0.896241935033413 0.942820816961673 GO:0140142 nucleocytoplasmic carrier activity 1/1273 32/18639 0.03125 0.457555970149254 0.896241935033413 0.942820816961673 GO:0051536 iron-sulfur cluster binding 3/1273 76/18639 0.0394736842105263 0.577965435978005 0.899261211189242 0.944528406305058 GO:0004896 cytokine receptor activity 4/1273 96/18639 0.0416666666666667 0.610074626865672 0.900792586540951 0.944528406305058 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/1273 56/18639 0.0357142857142857 0.522921108742004 0.903173674406002 0.944528406305058 GO:0019956 chemokine binding 1/1273 33/18639 0.0303030303030303 0.443690637720489 0.903340554730434 0.944528406305058 GO:0030296 protein tyrosine kinase activator activity 1/1273 33/18639 0.0303030303030303 0.443690637720489 0.903340554730434 0.944528406305058 GO:0140416 transcription regulator inhibitor activity 1/1273 33/18639 0.0303030303030303 0.443690637720489 0.903340554730434 0.944528406305058 GO:0051540 metal cluster binding 3/1273 77/18639 0.038961038961039 0.570459391354914 0.904093771030786 0.944528406305058 GO:0015294 solute:monoatomic cation symporter activity 5/1273 116/18639 0.0431034482758621 0.631111682964488 0.904627129474283 0.944528406305058 GO:0030594 neurotransmitter receptor activity 4/1273 97/18639 0.0412371134020619 0.603785197722727 0.905106011152632 0.944528406305058 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.948744095539828 GO:0140375 immune receptor activity 7/1273 156/18639 0.0448717948717949 0.657003444316877 0.914639789486492 0.952783596146533 GO:0015459 potassium channel regulator activity 2/1273 59/18639 0.0338983050847458 0.496331899822919 0.918356627649953 0.955807341188869 GO:0004540 RNA nuclease activity 5/1273 121/18639 0.0413223140495868 0.605032687800666 0.922539579865576 0.959310422287145 GO:0023023 MHC protein complex binding 1/1273 37/18639 0.027027027027027 0.395724082291247 0.92720242829812 0.962852127314574 GO:0016741 transferase activity, transferring one-carbon groups 10/1273 215/18639 0.0465116279069767 0.681013536966331 0.927585822821792 0.962852127314574 GO:0005507 copper ion binding 2/1273 63/18639 0.0317460317460317 0.464818763326226 0.935137923953883 0.969833853994575 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/1273 39/18639 0.0256410256410256 0.375430539609644 0.936825341775174 0.97072634708213 GO:0004536 DNA nuclease activity 2/1273 64/18639 0.03125 0.457555970149254 0.938791151542263 0.971905477875324 GO:0019843 rRNA binding 2/1273 65/18639 0.0307692307692308 0.450516647531573 0.942248425837478 0.974221166846057 GO:0008168 methyltransferase activity 9/1273 204/18639 0.0441176470588235 0.645961369622476 0.943203517078926 0.974221166846057 GO:0004812 aminoacyl-tRNA ligase activity 1/1273 41/18639 0.024390243902439 0.357116854750637 0.945177094580629 0.974221166846057 GO:0008227 G protein-coupled amine receptor activity 1/1273 41/18639 0.024390243902439 0.357116854750637 0.945177094580629 0.974221166846057 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/1273 41/18639 0.024390243902439 0.357116854750637 0.945177094580629 0.974221166846057 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/1273 130/18639 0.0384615384615385 0.563145809414466 0.947397485400173 0.974927010420535 GO:0042054 histone methyltransferase activity 2/1273 67/18639 0.0298507462686567 0.437068389396302 0.94861350063075 0.974927010420535 GO:0048487 beta-tubulin binding 1/1273 42/18639 0.0238095238095238 0.34861407249467 0.948929624884902 0.974927010420535 GO:0140223 general transcription initiation factor activity 2/1273 68/18639 0.0294117647058824 0.430640913081651 0.951539481030456 0.974927010420535 GO:0008200 ion channel inhibitor activity 1/1273 43/18639 0.0232558139534884 0.340506768483166 0.952425489138358 0.974927010420535 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/1273 43/18639 0.0232558139534884 0.340506768483166 0.952425489138358 0.974927010420535 GO:0004518 nuclease activity 9/1273 209/18639 0.0430622009569378 0.630507748339642 0.952498156483704 0.974927010420535 GO:0043022 ribosome binding 4/1273 112/18639 0.0357142857142857 0.522921108742004 0.952505350044594 0.974927010420535 GO:0008080 N-acetyltransferase activity 2/1273 69/18639 0.0289855072463768 0.424399740428293 0.954305889692182 0.975069725412203 GO:0098960 postsynaptic neurotransmitter receptor activity 2/1273 69/18639 0.0289855072463768 0.424399740428293 0.954305889692182 0.975069725412203 GO:0016248 channel inhibitor activity 1/1273 44/18639 0.0227272727272727 0.332767978290366 0.955682229960409 0.97562690258567 GO:0141110 transporter inhibitor activity 1/1273 45/18639 0.0222222222222222 0.325373134328358 0.958716191845884 0.977713857703615 GO:0140299 molecular sensor activity 2/1273 71/18639 0.028169014084507 0.412444818162708 0.959392132942559 0.977713857703615 GO:0005261 monoatomic cation channel activity 16/1273 341/18639 0.0469208211143695 0.687004858405918 0.960433049542378 0.977909155303155 GO:0008276 protein methyltransferase activity 3/1273 95/18639 0.0315789473684211 0.462372348782404 0.961803876152328 0.977909155303155 GO:0043021 ribonucleoprotein complex binding 7/1273 177/18639 0.0395480225988701 0.579053883126739 0.962082686861282 0.977909155303155 GO:0140938 histone H3 methyltransferase activity 1/1273 47/18639 0.0212765957446809 0.31152746903779 0.964175651203362 0.978975133348692 GO:0140767 enzyme-substrate adaptor activity 5/1273 139/18639 0.0359712230215827 0.526683131107055 0.964799173155397 0.978975133348692 GO:0003684 damaged DNA binding 2/1273 74/18639 0.027027027027027 0.395724082291247 0.966016270092827 0.979363645154558 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/1273 122/18639 0.0327868852459016 0.480058722779545 0.970748724092092 0.983312340020808 GO:0015370 solute:sodium symporter activity 2/1273 79/18639 0.0253164556962025 0.37067825429813 0.974810276904803 0.985830614479273 GO:0016874 ligase activity 6/1273 167/18639 0.0359281437125748 0.526052372866208 0.974957353556769 0.985830614479273 GO:0000049 tRNA binding 2/1273 80/18639 0.025 0.366044776119403 0.976283403314958 0.985830614479273 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/1273 53/18639 0.0188679245283019 0.276260208392002 0.976593700714987 0.985830614479273 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 9/1273 229/18639 0.0393013100436681 0.57544156944535 0.977573374780325 0.985971771470878 GO:0003823 antigen binding 6/1273 174/18639 0.0344827586206897 0.50488934637159 0.981656611541155 0.989240224849198 GO:0003730 mRNA 3'-UTR binding 10/1273 262/18639 0.0381679389312977 0.558846986441837 0.986786868211691 0.993535987681478 GO:0140101 catalytic activity, acting on a tRNA 4/1273 139/18639 0.0287769784172662 0.421346504885644 0.987612008197857 0.993535987681478 GO:0016410 N-acyltransferase activity 2/1273 94/18639 0.0212765957446809 0.31152746903779 0.989914191806476 0.994999367449318 GO:0016407 acetyltransferase activity 2/1273 96/18639 0.0208333333333333 0.305037313432836 0.991087794137705 0.995326835173367 GO:0004519 endonuclease activity 3/1273 127/18639 0.0236220472440945 0.345869079797861 0.993444818699671 0.996841211242234 GO:0004521 RNA endonuclease activity 1/1273 73/18639 0.0136986301369863 0.200572480065426 0.994341074223449 0.996888489443492 GO:0003735 structural constituent of ribosome 4/1273 175/18639 0.0228571428571429 0.334669509594883 0.998207993476556 0.999911420086585 GO:0045182 translation regulator activity 6/1273 356/18639 0.0168539325842697 0.24677175918162 0.999998816035894 0.999999979449485 GO:0030371 translation repressor activity 3/1273 329/18639 0.00911854103343465 0.133511772444767 0.999999979449485 0.999999979449485