category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 4/8 203/9376 23.0935960591133 FN1/SPP1/JUN/FLT1 9.29963540695609 NA NA hsa04518 Integrin signaling 3/8 154/9376 22.8311688311688 FN1/SPP1/FLT1 7.98237231608088 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 3/8 300/9376 11.72 HSPB1/JUN/FLT1 5.51461705685709 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 2/8 89/9376 26.3370786516854 FN1/SPP1 7.01812357152035 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 2/8 95/9376 24.6736842105263 JUN/FLT1 6.77699955493965 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 3/8 362/9376 9.71270718232044 FN1/SPP1/FLT1 4.9403283845969 Human Diseases Endocrine and metabolic disease hsa04933 AGE-RAGE signaling pathway in diabetic complications 2/8 101/9376 23.2079207920792 FN1/JUN 6.55720585828407 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 2/8 103/9376 22.7572815533981 FN1/HSPB1 6.48814138215396 Organismal Systems Immune system hsa04620 Toll-like receptor signaling pathway 2/8 109/9376 21.5045871559633 SPP1/JUN 6.29219086168048 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 2/8 138/9376 16.9855072463768 FN1/JUN 5.5282054734682 Genetic Information Processing Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum 2/8 174/9376 13.4712643678161 DNAJA1/HSPH1 4.85233957477516 Environmental Information Processing Signal transduction hsa04310 Wnt signaling pathway 2/8 178/9376 13.1685393258427 NOTUM/JUN 4.78970691156182 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 2/8 333/9376 7.03903903903904 FN1/SPP1 3.27899594115835 Human Diseases Substance dependence hsa05030 Cocaine addiction 1/8 49/9376 23.9183673469388 JUN 4.70021710376753 Environmental Information Processing Signal transduction hsa04370 VEGF signaling pathway 1/8 60/9376 19.5333333333333 HSPB1 4.20844458346104 Organismal Systems Endocrine system hsa04929 GnRH secretion 1/8 65/9376 18.0307692307692 SPP1 4.02624288068527 Human Diseases Immune disease hsa05321 Inflammatory bowel disease 1/8 66/9376 17.7575757575758 JUN 3.99222959093208 Human Diseases Substance dependence hsa05031 Amphetamine addiction 1/8 69/9376 16.9855072463768 JUN 3.89451428156504 Human Diseases Cancer: specific types hsa05211 Renal cell carcinoma 1/8 70/9376 16.7428571428571 JUN 3.86329828310234 Human Diseases Infectious disease: bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection 1/8 71/9376 16.5070422535211 JUN 3.83272047289852 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 1/8 78/9376 15.025641025641 FN1 3.63481607782189 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 1/8 78/9376 15.025641025641 JUN 3.63481607782189 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 1/8 78/9376 15.025641025641 JUN 3.63481607782189 Environmental Information Processing Signal transduction hsa04012 ErbB signaling pathway 1/8 86/9376 13.6279069767442 JUN 3.43779466512885 Human Diseases Cancer: specific types hsa05210 Colorectal cancer 1/8 87/9376 13.4712643678161 JUN 3.41501661589778 Human Diseases Cancer: overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 1/8 90/9376 13.0222222222222 JUN 3.34887438056139 Organismal Systems Immune system hsa04662 B cell receptor signaling pathway 1/8 91/9376 12.8791208791209 JUN 3.32752429024203 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 1/8 93/9376 12.6021505376344 JUN 3.285814076765 Organismal Systems Endocrine system hsa04912 GnRH signaling pathway 1/8 93/9376 12.6021505376344 JUN 3.285814076765 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 1/8 93/9376 12.6021505376344 FN1 3.285814076765 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 1/8 94/9376 12.468085106383 JUN 3.26543649870275 Human Diseases Drug resistance: antineoplastic hsa01522 Endocrine resistance 1/8 99/9376 11.8383838383838 JUN 3.16800265606827 Human Diseases Cancer: overview hsa05231 Choline metabolism in cancer 1/8 99/9376 11.8383838383838 JUN 3.16800265606827 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 1/8 103/9376 11.378640776699 JUN 3.09496793285256 Cellular Processes Transport and catabolism hsa04137 Mitophagy - animal 1/8 105/9376 11.1619047619048 JUN 3.05994534911955 Organismal Systems Immune system hsa04625 C-type lectin receptor signaling pathway 1/8 105/9376 11.1619047619048 JUN 3.05994534911955 Organismal Systems Immune system hsa04659 Th17 cell differentiation 1/8 109/9376 10.7522935779817 JUN 2.99266169394468 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 1/8 110/9376 10.6545454545455 FLT1 2.97638575199795 Environmental Information Processing Signal transduction hsa04668 TNF signaling pathway 1/8 119/9376 9.84873949579832 JUN 2.83874870617589 Organismal Systems Nervous system hsa04722 Neurotrophin signaling pathway 1/8 120/9376 9.76666666666667 JUN 2.8243637869906 Organismal Systems Immune system hsa04660 T cell receptor signaling pathway 1/8 122/9376 9.60655737704918 JUN 2.79609438141271 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 1/8 130/9376 9.01538461538462 JUN 2.6892197302464 Human Diseases Infectious disease: viral hsa05162 Measles 1/8 136/9376 8.61764705882353 JUN 2.61493866259189 Cellular Processes Cell growth and death hsa04210 Apoptosis 1/8 137/9376 8.55474452554745 JUN 2.60300362743414 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 1/8 139/9376 8.43165467625899 JUN 2.57949470216609 Environmental Information Processing Signal transduction hsa04371 Apelin signaling pathway 1/8 140/9376 8.37142857142857 SPP1 2.56791656008247 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 1/8 142/9376 8.25352112676056 JUN 2.54510267884295 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 1/8 142/9376 8.25352112676056 JUN 2.54510267884295 Human Diseases Cancer: specific types hsa05224 Breast cancer 1/8 148/9376 7.91891891891892 JUN 2.47926241514055 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 1/8 154/9376 7.61038961038961 JUN 2.41703004692752 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 1/8 157/9376 7.46496815286624 JUN 2.38715983807449 Human Diseases Infectious disease: viral hsa05161 Hepatitis B 1/8 163/9376 7.19018404907975 JUN 2.32972156169015 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 1/8 170/9376 6.89411764705882 JUN 2.26628730610123 Organismal Systems Immune system hsa04621 NOD-like receptor signaling pathway 1/8 187/9376 6.26737967914438 JUN 2.12612352141385 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 1/8 196/9376 5.97959183673469 JUN 2.05876905608674 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 1/8 200/9376 5.86 JUN 2.03016695883304 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 1/8 201/9376 5.83084577114428 FLT1 2.02313729198338 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 1/8 204/9376 5.74509803921569 FN1 2.00232901788136 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 1/8 205/9376 5.71707317073171 JUN 1.99548463215177 Human Diseases Cancer: overview hsa05203 Viral carcinogenesis 1/8 205/9376 5.71707317073171 JUN 1.99548463215177 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 1/8 212/9376 5.52830188679245 FLT1 1.94880306044896 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 1/8 214/9376 5.47663551401869 JUN 1.93584539334682 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 1/8 216/9376 5.42592592592593 JUN 1.92304953209702 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 1/8 217/9376 5.40092165898618 JUN 1.91671113478509 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 1/8 224/9376 5.23214285714286 JUN 1.87341292902484 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 1/8 226/9376 5.1858407079646 JUN 1.86137364486955 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 1/8 227/9376 5.16299559471366 JUN 1.85540728208206 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 1/8 232/9376 5.05172413793103 FN1 1.82609321628515 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 1/8 233/9376 5.03004291845494 FN1 1.8203314082622 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 1/8 238/9376 4.92436974789916 FLT1 1.7920082779825 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 1/8 238/9376 4.92436974789916 JUN 1.7920082779825 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 1/8 248/9376 4.7258064516129 JUN 1.73766280781864 Human Diseases Infectious disease: bacterial hsa05131 Shigellosis 1/8 253/9376 4.63241106719368 JUN 1.71156581605925 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 1/8 254/9376 4.61417322834646 FLT1 1.70642804307295