category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	63/1305	122/9376	3.71011871113624	JUN/PTPRC/FYN/CD247/NFKB1/CBLB/NFKBIA/PPP2R5C/LCK/LCP2/NFATC3/CD3E/CD3G/PRKCQ/ZAP70/NFATC2/CD3D/ITK/GRAP2/PIK3CD/PPP3CA/PPP3CC/MALT1/IFNG/MAPK1/RASGRP1/LAT/SOS1/SOS2/MAPK14/PIK3R1/MAP3K8/PTPN6/GSK3B/MAPK8/NFKBIE/FOS/CARD11/NCK2/MAP3K14/PIK3CA/PPP2R5A/IKBKB/RAF1/PPP2R2A/MAP3K7/MAP2K1/CD28/DLG1/NCK1/ICOS/PPP2R2D/VAV1/CD8B/PPP2R5E/AKT2/CD8A/GRB2/PPP2R2B/PPP2R3C/PPP2R1A/NFATC1/CHUK	12.1152032039303
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	44/1305	90/9376	3.51250744997871	JUN/CD247/NFKB1/JAK1/NFKBIA/LCK/NFATC3/STAT3/CD3E/CD3G/PRKCQ/ZAP70/NFATC2/CD3D/PIK3CD/PPP3CA/PPP3CC/IFNG/STAT1/MAPK1/RASGRP1/LAT/MAPK14/PIK3R1/PTPN6/NFKBIE/FOS/BATF/PIK3CA/IKBKB/MAP2K6/RAF1/HIF1A/MAP2K1/CD28/EML4/PTEN/AKT2/MAP3K3/MAP2K3/RPS6KB1/TICAM1/NFATC1/CHUK	9.63033719310318
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	56/1305	142/9376	2.8333926933247	JUN/JUNB/FYN/NFKB1/JAK1/CYBA/NFKBIA/LCK/LCP2/FOSB/TGFBR2/SOCS1/CYLD/TGFB1/NFATC2/CAMK4/CREB1/PIK3CD/JUND/PPP3CA/PPP3CC/ITPR1/IFNG/STAT1/MAPK1/TAB2/MAPK14/PIK3R1/TYROBP/FCGR3A/ITPR2/MAPK8/FOS/MAP3K14/PIK3CA/RELB/IKBKB/PLCG2/MAP2K6/ATP2A2/SOCS3/ATP2A3/IFNAR1/MAP3K7/MAP2K1/FOSL2/SIRPG/NFKB2/TYK2/TAB1/SQSTM1/AKT2/TMEM64/GRB2/NFATC1/CHUK	8.85180735546383
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	61/1305	163/9376	2.68874315398538	JUN/NFKB1/JAK1/NFKBIA/NFATC3/STAT3/PRKCB/TGFBR2/STAT4/BRAF/STAT5B/PRKCA/MYC/TGFB1/NFATC2/CREB1/CREBBP/CASP8/BCL2/PIK3CD/STAT1/JAK3/MAPK1/TAB2/SOS1/SOS2/MAPK14/PIK3R1/RB1/TP53/EP300/MAPK8/DDX3X/FOS/STAT6/IRAK4/MAP3K1/SMAD3/PIK3CA/IKBKB/MAP2K6/MAP2K4/CASP10/RAF1/IFNAR1/PTK2B/CYCS/MAP3K7/MAP2K1/TYK2/TAB1/ATF2/FAS/CASP9/AKT2/GRB2/MAP2K3/TICAM1/NFATC1/TRAF3/CHUK	8.7454888102172
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	47/1305	109/9376	3.09797883932651	JUN/CD247/NFKB1/JAK1/HSP90AA1/NFKBIA/IL2RG/LCK/NFATC3/STAT3/RORA/TGFBR2/CD3E/CD3G/PRKCQ/STAT5B/TGFB1/ZAP70/NFATC2/CD3D/PPP3CA/PPP3CC/IFNG/STAT1/JAK3/MAPK1/LAT/MAPK14/HSP90AB1/RUNX1/MAPK8/IL2RB/NFKBIE/FOS/STAT6/SMAD3/IL4R/IKBKB/SMAD2/TBX21/HIF1A/TYK2/IL21R/IL6R/NFATC1/IL12RB1/CHUK	8.85874073039174
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	54/1305	137/9376	2.83191542914674	JUN/ATM/NFKB1/NFKBIA/TUBA1A/GADD45B/MCL1/SPTAN1/CTSW/CASP8/ERN1/BCL2/PIK3CD/ITPR1/EIF2AK3/MAPK1/TUBA4A/PRF1/PIK3R1/BIRC3/PMAIP1/TNFSF10/CTSC/ITPR2/TP53/MAPK8/FOS/MAP3K14/PIK3CA/TRAF1/IKBKB/CASP10/DDIT3/RAF1/CYCS/MAP2K1/GZMB/BIRC2/PARP4/CFLAR/TRADD/CTSS/CTSD/FAS/BCL2L11/CASP9/RIPK1/AKT2/CASP2/AIFM1/HTRA2/MAP3K5/BAK1/CHUK	8.68521234283837
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	53/1305	138/9376	2.75933144538842	JUN/FYB1/NFKB1/RAC2/WIPF1/ITGA4/NFKBIA/ELMO1/LCK/LCP2/NFATC3/ARHGEF1/RPS6KA3/ROCK1/ZAP70/NFATC2/PIK3CD/MAPK1/TAB2/LAT/MAPK14/PIK3R1/GSK3B/ACTR2/GIT2/MAPK8/PKN1/PKN2/FOS/IRAK4/WAS/ARHGEF7/ITGA5/PIK3CA/IKBKB/MAP2K6/MAP2K4/ARPC4/PTK2B/MAP3K7/MAP2K1/PYCARD/TAB1/VAV1/CD8B/ROCK2/AKT2/CD8A/SKAP2/MAP2K3/TICAM1/NFATC1/CHUK	8.37192732670966
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	68/1305	205/9376	2.38320904588356	JUN/CD247/NFKB1/JAK1/TNFAIP3/NFKBIA/CCND3/RUNX3/STAT3/CD3E/CD44/CCND2/CD3G/GADD45B/MYC/CDKN1B/ITGAL/CD3D/CASP8/BCL2/PIK3CD/STAT1/JAK3/TAB2/MAPK14/B2M/PIK3R1/RB1/ISG15/ICAM1/TP53/MAPK8/NFKBIE/IRAK4/CD58/MAP3K14/PIK3CA/RELB/IKBKB/PLCG2/MAP2K6/PSMD12/MAP2K4/VIM/IFNAR1/CYCS/MAP3K7/NFKB2/TYK2/TAB1/TRAF5/LYN/TRADD/FAS/BCL2L11/USP7/SAP30L/CASP9/RIPK1/AKT2/HDAC1/MAP2K3/POLK/BAK1/TRAF3/TAPBP/CHUK/TAPBPL	8.05162657571319
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	41/1305	93/9376	3.16743706999547	JUN/CD247/NFKB1/JAK1/NFKBIA/IL2RG/LCK/RUNX3/NFATC3/CD3E/STAT4/CD3G/PRKCQ/STAT5B/MAML2/ZAP70/NFATC2/CD3D/PPP3CA/PPP3CC/IFNG/STAT1/JAK3/MAPK1/LAT/MAPK14/MAPK8/IL2RB/NFKBIE/FOS/STAT6/IL4R/IKBKB/TBX21/IL12RB2/TYK2/MAF/NFATC1/IL12RB1/NOTCH1/CHUK	8.44638777997085
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	51/1305	133/9376	2.75502549477141	FYN/CD247/RAC2/CD48/ITGB2/LCK/LCP2/PRKCB/BRAF/PRKCA/HCST/ZAP70/NFATC2/ITGAL/PIK3CD/PPP3CA/PPP3CC/IFNG/KLRD1/FCER1G/ICAM2/MAPK1/SH2D1A/PRF1/LAT/SOS1/SOS2/PIK3R1/PTPN6/TNFSF10/TYROBP/FCGR3A/ICAM1/KLRC4-KLRK1/PIK3CA/PLCG2/KLRC1/LAT2/RAF1/IFNAR1/PTK2B/MAP2K1/GZMB/VAV1/FAS/KLRC2/SH3BP2/GRB2/CD244/NFATC1/SH2D1B	8.19652926956706
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	70/1305	216/9376	2.3283666808571	JUN/NFKB1/CYBA/HSP90AA1/NFKBIA/NFATC3/STAT3/ARHGEF1/SOD2/PRKCA/HSPA4/RAP1B/HSPA8/NFATC2/CAMK2D/CASP8/ERN1/BCL2/PIK3CD/PPP3CA/PPP3CC/ITPR1/NFE2L2/EIF2AK3/TANK/MAPK1/TAB2/RAP1A/MAPK14/PIK3R1/HSP90AB1/PLCB1/TNFSF10/GSK3B/ICAM1/TP53/ABCG1/MAPK8/FOS/IRAK4/XBP1/PIK3CA/IKBKB/MAP2K6/MAP2K4/HSPD1/LDLR/DDIT3/CYCS/ATF6/MAP3K7/MIB1/PYCARD/TAB1/LYN/HSPA5/VAV1/ROCK2/FAS/HSPA6/CASP9/AKT2/POU2F1/MAP2K3/MAP3K5/PLCB2/TICAM1/NFATC1/TRAF3/CHUK	7.94189850966507
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	39/1305	87/9376	3.22071607874224	JUN/RAC2/TGFBR2/GADD45B/BRAF/MYC/TGFB1/LEF1/BCL2/PIK3CD/TCF7/MAPK1/SOS1/SOS2/PIK3R1/PMAIP1/GSK3B/TP53/MAPK8/FOS/SMAD3/PIK3CA/SMAD2/RALGDS/AREG/MSH3/RAF1/CYCS/MAP2K1/CTNNB1/BCL2L11/CASP9/APC/AKT2/GRB2/RPS6KB1/POLK/RALA/BAK1	8.3674938585187
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	47/1305	119/9376	2.83764448308059	JUN/JUNB/NFKB1/IRF1/TNFAIP3/NFKBIA/CYLD/CREB1/CASP8/PIK3CD/RPS6KA5/MAPK1/TNFRSF1B/TAB2/MAPK14/PIK3R1/BIRC3/MAP3K8/ICAM1/MAPK8/ADAM17/FOS/MAP3K14/PIK3CA/TRAF1/IKBKB/MAP2K6/MAP2K4/SOCS3/CASP10/MAP3K7/MAP2K1/BIRC2/TAB1/CEBPB/TRAF5/DNM1L/CFLAR/TRADD/ATF2/FAS/RIPK1/AKT2/MAP2K3/MAP3K5/TRAF3/CHUK	8.11198360623603
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	71/1305	224/9376	2.27728516694034	ZFP36/JUN/ATM/NFKB1/ETS1/JAK1/ITGB2/NFKBIA/IL2RG/CCND3/LCK/NFATC3/PRKACB/TGFBR2/CD3E/CCND2/CD3G/STAT5B/MYC/TGFB1/NFATC2/ITGAL/CREB1/CREBBP/CD3D/PIK3CD/PPP3CA/PPP3CC/JAK3/MAPK1/ATR/B2M/PIK3R1/RB1/CRTC3/TRRAP/EGR1/ICAM1/TP53/EP300/MAPK8/IL2RB/FOS/MAP3K1/SMAD3/NFYB/TBPL1/MAP3K14/PIK3CA/RELB/IKBKB/SMAD2/MAP2K4/TLN1/POLB/ADCY7/MAP2K1/DLG1/NFKB2/ELK4/ANAPC1/TCF3/CDC27/ATF2/PTEN/AKT2/MAP3K3/CRTC1/CRTC2/NFATC1/CHUK	7.78002679233129
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	67/1305	214/9376	2.24940738353565	JUN/CD247/ATM/NFKB1/RAC2/GNG2/NFKBIA/CXCR4/NFATC3/PRKCB/CD3E/CD3G/PRKCA/NFATC2/CD3D/CASP8/SAMHD1/BCL2/PIK3CD/PPP3CA/PPP3CC/ITPR1/MAPK1/TNFRSF1B/TAB2/ATR/MAPK14/B2M/PIK3R1/AP1S2/ITPR2/CUL5/APOBEC3G/MAPK8/FOS/IRAK4/GNAI3/BTRC/PIK3CA/IKBKB/PLCG2/MAP2K6/GNAI2/RAF1/PTK2B/CYCS/BST2/CGAS/MAP3K7/MAP2K1/TAB1/GNB5/TRAF5/TRADD/FAS/CASP9/APOBEC3C/RIPK1/AKT2/CUL4A/MAP2K3/RPS6KB1/NFATC1/BAK1/TAPBP/CHUK/TAPBPL	7.43435048250461
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	63/1305	196/9376	2.30935960591133	ZFP36/JUN/NFKB1/JAK1/PREX1/GNG2/NFKBIA/NFATC3/STAT3/PIK3R5/CLEC2B/MYC/LEF1/NFATC2/CREB1/CREBBP/CASP8/PIK3CD/PPP3CA/PPP3CC/ITPR1/TCF7/STAT1/MAPK1/MAPK14/PIK3R1/RB1/ATG14/PIK3CG/MAPKAPK2/GSK3B/ITPR2/ICAM1/TP53/EP300/MAPK8/FOS/PIK3CA/IKBKB/PLCG2/MAP2K6/MAP2K4/RAF1/IFNAR1/CYCS/HIF1A/MAP2K1/CTNNB1/TYK2/PIK3C3/GNB5/LYN/BECN1/TRADD/FAS/CASP9/AKT2/TICAM1/NFATC1/UBC/BAK1/TRAF3/CHUK	7.4489121804333
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	84/1305	300/9376	2.01170881226054	JUN/DUSP2/NR4A1/NFKB1/RAC2/STK4/RASA2/TAOK3/NFATC3/PRKACB/PRKCB/TGFBR2/GADD45B/RPS6KA3/BRAF/PRKCA/MYC/RAP1B/HSPA8/TGFB1/MAX/JUND/PPP3CA/DUSP1/PPP3CC/RPS6KA5/ARRB2/DUSP10/MAP3K2/MAPK1/RASGRP1/RAPGEF2/TAB2/PTPN7/RAP1A/SOS1/SOS2/MAPK14/MKNK2/MAP3K8/MAPKAPK2/TP53/RASGRP2/MAPK8/MAP4K4/FOS/IRAK4/TAOK1/MAP3K1/DUSP5/FLNA/MAP3K14/RELB/IKBKB/MAP2K6/MAP2K4/AREG/DDIT3/RAF1/MAP3K7/MAP2K1/MAP2K5/NFKB2/ELK4/TAB1/DUSP6/RRAS2/IGF1R/TRADD/ATF2/MAP3K4/FAS/FLT3LG/HSPA6/AKT2/PPM1A/GRB2/MAP3K11/MAP3K3/MAP2K3/CDC25B/MAP3K5/NFATC1/CHUK	7.1613704017787
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	73/1305	248/9376	2.1148436534421	JUN/PTPRC/NFKB1/RHOH/CYTH1/HSP90AA1/NFKBIA/ELMO1/TUBA1A/MYC/EXOC4/LEF1/GCC2/CASP8/BCL2/PIK3CD/ABI1/KPNA4/DYNC1H1/TCF7/MAPK1/TUBA4A/TAB2/DCTN4/CYFIP2/KPNA1/MAPK14/BIRC3/HSP90AB1/RIPK2/TNFSF10/PIK3CG/ACTR2/MAPK8/PKN1/EXOC2/RAB7A/FOS/IRAK4/KPNA3/FLNA/PIK3CA/IKBKB/PIK3C2A/MAP2K6/MAP2K4/ARPC4/RAF1/CYCS/NCKAP1L/MAP3K7/MAP2K1/BIRC2/CTNNB1/PYCARD/TAB1/PIK3C3/VPS41/TRADD/CYTH4/ROCK2/TUBB2A/ACTR1B/RIPK1/AKT2/SNX18/MAP2K3/DYNC1LI2/VPS39/RALA/BAK1/RHOB/CHUK	7.15449873032258
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	47/1305	133/9376	2.53894506380895	KLF2/ATM/STK4/STAT3/IL7R/RBL2/TGFBR2/CCND2/GADD45B/BRAF/SOD2/S1PR4/CDKN1B/TGFB1/CREBBP/FOXO1/PIK3CD/SIRT1/MAPK1/SOS1/SOS2/MAPK14/PIK3R1/TNFSF10/CDKN2D/EP300/FOXO3/MAPK8/BCL6/SMAD3/PIK3CA/PLK3/IKBKB/SGK1/RAF1/PRKAG2/MAP2K1/TPTEP2-CSNK1E/IGF1R/BCL2L11/USP7/PTEN/IRS2/AKT2/GRB2/PRKAA1/CHUK	7.18736468350207
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	52/1305	157/9376	2.37963735754204	ATM/NFKB1/ZFP36L2/ETS1/CCND3/NFATC3/RBL2/TGFBR2/CCND2/GADD45B/MYC/TGFB1/NFATC2/FOXO1/HIPK1/PIK3CD/PPP3CA/PPP3CC/ITPR1/SIRT1/MAPK1/RASSF5/ATR/MAPK14/PIK3R1/RB1/E2F5/MAPKAPK2/ITPR2/TP53/HIPK2/FOXO3/ZFP36L1/SMAD3/BTRC/PIK3CA/SMAD2/MAP2K6/RAD9A/RAF1/TRPM7/MAP2K1/HUS1/PPP1CB/RRAS2/RBBP4/PTEN/SQSTM1/AKT2/LIN52/MAP2K3/NFATC1	7.00971054281243
Human Diseases	Infectious disease: viral	hsa05162	Measles	47/1305	136/9376	2.48293892269551	JUN/NFKB1/CBLB/MSN/JAK1/TNFAIP3/NFKBIA/IL2RG/CCND3/STAT3/CD3E/CCND2/CD3G/STAT5B/CDKN1B/HSPA8/CD3D/CASP8/BCL2/PIK3CD/STAT1/JAK3/TAB2/PIK3R1/GSK3B/TP53/MAPK8/IL2RB/FOS/IRAK4/PIK3CA/IKBKB/IFNAR1/CYCS/ADAR/MAP3K7/CD28/TYK2/MX2/TRADD/FAS/HSPA6/CASP9/AKT2/BAK1/TRAF3/CHUK	7.00460989357564
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	34/1305	83/9376	2.94311960485621	ASXL1/KDM2A/SFMBT2/OGT/MBD5/JARID2/MAX/CREBBP/PCGF5/EZH2/PHC3/EP300/YAF2/MGA/MTF2/KDM2B/AEBP2/CBX4/LCOR/AUTS2/FBRSL1/ASXL2/UBE2D3/UBE2D2/L3MBTL3/EZH1/RBBP4/USP7/HDAC1/SCML1/BCOR/FBRS/DCAF7/FOXK1	7.14970020211505
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	66/1305	227/9376	2.08893614866576	NFKB1/RAC2/JAK1/GNG2/NFKBIA/CXCR4/AKAP13/NFATC3/PRKACB/STAT3/PRKCB/ARHGEF1/ROCK1/PRKCA/MYC/PTGER4/NFATC2/CREB1/CASP8/PIK3CD/PPP3CA/PPP3CC/ITPR1/MAPK1/SOS1/SOS2/MAPK14/B2M/PIK3R1/RB1/PLCB1/GSK3B/ITPR2/TP53/IL10RA/GNAI3/PIK3CA/IKBKB/MAP2K6/GNAI2/RAF1/PTK2B/ADCY7/CYCS/CGAS/MAP2K1/CTNNB1/GNB5/TRAF5/TRADD/ATF2/ROCK2/FAS/CASP9/RIPK1/AKT2/GRB2/IL6R/RPS6KB1/GNA13/PLCB2/NFATC1/BAK1/TAPBP/CHUK/TAPBPL	6.67814355015708
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	38/1305	103/9376	2.65065654874828	JUN/CD247/NFKB1/NFKBIA/TGFBR2/CD3E/CD3G/TGFB1/CD3D/CASP8/PIK3CD/IFNG/MAPK1/MAPK14/PIK3R1/PLCB1/MAPK8/FOS/IRAK4/GNAI3/PIK3CA/IKBKB/SMAD2/MAP2K4/GNAI2/PPP2R2A/C1QB/PPP2R2D/C1QA/CFLAR/FAS/AKT2/PPP2R2B/PPP2R1A/PLCB2/TICAM1/C1QC/CHUK	6.77317695518411
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	43/1305	125/9376	2.47152796934866	FYN/NFKB1/RAC2/PPP2R5C/PRKCB/ROCK1/PRKCA/S1PR4/BCL2/PIK3CD/FCER1G/MAPK1/MAPK14/PIK3R1/CERS6/PLCB1/TP53/MAPK8/GNAI3/PIK3CA/PPP2R5A/SGMS1/GNAI2/RAF1/PPP2R2A/MAP2K1/PPP2R2D/DEGS1/TRADD/CTSD/ROCK2/NSMAF/PTEN/PPP2R5E/AKT2/GNA13/PPP2R2B/CERS4/PPP2R3C/PPP2R1A/MAP3K5/PLCB2/SPTLC2	6.65972670739241
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	69/1305	253/9376	1.9594566353187	JUN/ATM/NFKB1/FNBP1/CYTH1/NFKBIA/ELMO1/SEPTIN6/CD44/PRKCQ/ROCK1/FOXO1/SEPTIN9/BCL2/PIK3CD/ITPR1/MALT1/RPS6KA5/MAPK1/TAB2/DIAPH1/MAPK14/PIK3R1/ATG14/RIPK2/PLCB1/GSK3B/ITPR2/ACTR2/TP53/FOXO3/MAPK8/ITGA5/TECPR1/BTRC/PIK3CA/IKBKB/PLCG2/TLN1/ARPC4/CYCS/CGAS/MAP3K7/UBE2D3/GLMN/UBE2D2/PYCARD/TAB1/HCLS1/PIK3C3/TRAF5/H3C12/BECN1/VCL/TRADD/CYTH4/ROCK2/SQSTM1/ILK/RIPK1/AKT2/SEPTIN7/TNIP1/RPS6KB1/RPTOR/U2AF1L4/PLCB2/UBC/CHUK	6.22076784691269
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	41/1305	120/9376	2.45476372924649	JUN/NFKB1/NFKBIA/ARHGDIB/RPS6KA3/BRAF/RAP1B/CAMK4/CAMK2D/BCL2/PIK3CD/RPS6KA5/MAPK1/RAP1A/SOS1/SOS2/MAPK14/MATK/PIK3R1/RIPK2/MAPKAPK2/GSK3B/TP53/FOXO3/MAPK8/NFKBIE/KIDINS220/IRAK4/MAP3K1/PIK3CA/IKBKB/PLCG2/SH2B3/RAF1/MAP2K1/PSEN1/MAP2K5/AKT2/GRB2/MAP3K3/MAP3K5	6.44909292818934
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	41/1305	122/9376	2.41452170089818	PRKACB/PRKCB/NCOR1/PRKCA/MYC/MED13L/NCOA1/CREBBP/FOXO1/PIK3CD/MED13/STAT1/MAPK1/ATP1A1/PIK3R1/PLCB1/GSK3B/TP53/EP300/TBC1D4/NCOA3/MED30/SLC16A10/PIK3CA/PLCG2/ATP2A2/MED1/RAF1/ATP2A3/HDAC3/HIF1A/NCOA2/MAP2K1/CTNNB1/CASP9/AKT2/HDAC1/ATP1B3/MED27/PLCB2/NOTCH1	6.32341962451
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	37/1305	105/9376	2.53174238277687	ATM/NFKB1/TNFAIP3/NFKBIA/LCK/PRKCB/GADD45B/PRKCQ/CYLD/ZAP70/BCL2/MALT1/TAB2/LAT/BIRC3/ICAM1/ERC1/IRAK4/CARD11/MAP3K14/TRAF1/RELB/IKBKB/PLCG2/MAP3K7/BIRC2/NFKB2/TAB1/TRAF5/LYN/CFLAR/TRADD/RIPK1/TNFSF14/TICAM1/TRAF3/CHUK	6.34664649024983
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	56/1305	193/9376	2.08467234431144	NFKB1/RAC2/PREX1/GNG2/NFKBIA/CXCR4/ELMO1/PRKACB/STAT3/PIK3R5/PRKCB/BRAF/ROCK1/STAT5B/RAP1B/DOCK2/ITK/PIK3CD/ARRB2/CCR7/GRK2/STAT1/JAK3/GRK5/MAPK1/RAP1A/SOS1/SOS2/PIK3R1/PLCB1/PIK3CG/GSK3B/RASGRP2/FOXO3/GRK6/WAS/GNAI3/PIK3CA/IKBKB/PLCG2/GNAI2/RAF1/PTK2B/ADCY7/MAP2K1/XCL2/GNB5/LYN/VAV1/ROCK2/FGR/AKT2/GRB2/CXCR3/PLCB2/CHUK	6.12226536588262
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	28/1305	68/9376	2.95839531214785	NFKB1/STAT3/BRAF/STAT5B/MYC/LEF1/PIK3CD/PIM2/TCF7/MAPK1/ZBTB16/SOS1/SOS2/PIK3R1/RUNX1/PIM1/PIK3CA/IKBKB/RAF1/MAP2K1/DUSP6/PPARD/ITGAM/PML/AKT2/GRB2/RPS6KB1/CHUK	6.51709197689406
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	53/1305	180/9376	2.11548744146445	ZC3HAV1/NFKB1/JAK1/NFKBIA/SRSF6/SP100/CASP8/SRSF7/BCL2/PIK3CD/IFNG/CD74/STAT1/TAB2/B2M/PIK3R1/BIRC3/NXF1/TP53/SRSF2/IRAK4/ITGA5/PIK3CA/IKBKB/SRSF4/SOCS3/IFNAR1/CYCS/BST2/CGAS/MAP3K7/BIRC2/TYK2/TAB1/TRAF5/SRSF1/PPP1CB/TRADD/FAS/CASP9/PML/EIF2B3/AKT2/POU2F1/PILRB/TNFSF14/TICAM1/BAK1/SRSF3/TRAF3/TAPBP/CHUK/TAPBPL	6.07615266154285
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	30/1305	77/9376	2.79922376474101	NFKB1/RAC2/JAK1/STAT3/TGFBR2/GADD45B/BRAF/TGFB1/PIK3CD/STAT1/MAPK1/PIK3R1/RB1/TP53/MAPK8/SMAD3/ARHGEF6/PIK3CA/IKBKB/SMAD2/RALGDS/RAF1/MAP2K1/CASP9/AKT2/RPS6KB1/POLK/RALA/BAK1/CHUK	6.37440477720184
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	30/1305	77/9376	2.79922376474101	NFKB1/NFKBIA/TGFBR2/GADD45B/BRAF/STAT5B/MYC/CDKN1B/TGFB1/PIK3CD/MAPK1/SOS1/SOS2/CBL/PIK3R1/RB1/RUNX1/TP53/SMAD3/PIK3CA/IKBKB/RAF1/MAP2K1/CTBP1/AKT2/HDAC1/GRB2/POLK/BAK1/CHUK	6.37440477720184
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	29/1305	73/9376	2.85418569254186	STK4/STAT3/PRKCB/GADD45B/BRAF/STAT5B/PRKCA/PIK3CD/JAK3/MAPK1/RASSF5/SOS1/SOS2/PIK3R1/RB1/TP53/FOXO3/RASSF1/PIK3CA/PLCG2/FHIT/RAF1/MAP2K1/EML4/CASP9/AKT2/GRB2/POLK/BAK1	6.39485005315627
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	57/1305	201/9376	2.03744495911248	REL/ATM/NFKB1/JMJD1C/NFKBIZ/BCL11B/MLLT3/TGFBR2/CCND2/FLI1/ZEB1/GADD45B/NCOR1/DDX5/MYC/CDKN1B/KLF3/MAX/FUS/FOXO1/KDM6A/ID2/KMT2A/ZBTB16/BIRC3/RUNX1/AFF1/TP53/IL2RB/NR4A3/BCL6/TAF15/ATF1/TRAF1/CCNT1/PRCC/SS18/PBX3/DDIT3/GZMB/BIRC2/ETV6/RUNX2/ELK4/CEBPB/H3C12/DUSP6/TCF3/IGF1R/SUPT3H/ITGAM/PML/MAF/HDAC1/POLK/BAK1/CCNT2	5.97843177424806
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	54/1305	187/9376	2.07471879033745	JUN/TXNIP/NFKB1/IFI16/JAK1/CYBA/HSP90AA1/TNFAIP3/NFKBIA/ERBIN/NLRP1/CASP8/BCL2/NEK7/ITPR1/STAT1/TANK/MAPK1/TAB2/MAPK14/BIRC3/HSP90AB1/RIPK2/PLCB1/GBP2/ITPR2/MAPK8/PKN1/PKN2/IRAK4/GBP5/GBP4/CARD16/PSTPIP1/IKBKB/NAMPT/CARD8/GBP3/TRPM7/IFNAR1/MAP3K7/BIRC2/TYK2/TP53BP1/PYCARD/TAB1/TRAF5/DNM1L/RIPK1/PLCB2/TICAM1/TRPV2/TRAF3/CHUK	5.96909842425522
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	40/1305	122/9376	2.35563092770555	JUNB/PRKACB/STAT3/PRKCB/SOCS1/STAT5B/PRKCA/CREB1/CREBBP/PIK3CD/ITPR1/STAT1/MAPK1/SOS1/SOS2/MAPK14/PIK3R1/PLCB1/GSK3B/ITPR2/EP300/MAPK8/FOS/MAP3K1/GNAI3/PIK3CA/PLCG2/MAP2K6/MAP2K4/SOCS3/GNAI2/RAF1/ADCY7/MAP2K1/ATF2/IRS2/AKT2/GRB2/MAP2K3/PLCB2	6.06015673453635
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	25/1305	59/9376	3.04435352944996	GADD45B/BRAF/MYC/LEF1/PIK3CD/TCF7/MAPK1/SOS1/SOS2/PIK3R1/GSK3B/TP53/FOXO3/PIK3CA/RAF1/MAP2K1/CTNNB1/PTEN/CASP9/ILK/APC/AKT2/GRB2/POLK/BAK1	6.33389965595718
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	44/1305	142/9376	2.22623711618369	CBLB/FBXW7/HERC1/SOCS1/SMURF2/BIRC6/UBR5/UBE2G1/HUWE1/CBL/BIRC3/COP1/UBE2O/PIAS1/CUL5/TRIP12/UBE2R2/HERC4/MAP3K1/UBE2S/UBE3A/UBE2G2/BTRC/PIAS2/UBA6/UBE2E1/UBE4A/CUL3/SOCS3/TRIM37/UBE2D3/BIRC2/UBE2D2/ANAPC1/CDC27/WWP2/PML/WWP1/CUL2/CUL4A/HERC2/SIAH1/UBC/VHL	5.92039815806946
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	32/1305	91/9376	2.52647888509957	JUN/NFKB1/RAC2/NFKBIA/NFATC3/PRKCB/NFATC2/PIK3CD/PPP3CA/PPP3CC/MALT1/MAPK1/SOS1/SOS2/PIK3R1/PTPN6/GSK3B/NFKBIE/FOS/CARD11/CD81/PIK3CA/IKBKB/PLCG2/RAF1/MAP2K1/LYN/VAV1/AKT2/GRB2/NFATC1/CHUK	5.88366265128184
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	35/1305	105/9376	2.3948914431673	JUN/NFKB1/CBLB/IRF1/NFKBIA/NFATC3/CYLD/NFATC2/CASP8/PIK3CD/PPP3CA/PPP3CC/ITPR1/MALT1/FCER1G/STAT1/MAPK1/MAPK14/PIK3R1/MAPKAPK2/ITPR2/MAPK8/MAP3K14/PIK3CA/PLK3/RELB/IKBKB/PLCG2/RAF1/NFKB2/PYCARD/RRAS2/AKT2/NFATC1/CHUK	5.77961606442468
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	45/1305	156/9376	2.07250221043324	NFKB1/JAK1/NFKBIA/STAT3/BRAF/MYC/CASP8/PIK3CD/IFNG/STAT1/MAPK1/SOS1/SOS2/PIK3R1/RB1/PIAS1/GSK3B/TP53/CD81/PIK3CA/IKBKB/LDLR/SOCS3/RAF1/IFNAR1/CYCS/PPP2R2A/MAP2K1/CTNNB1/TYK2/PPP2R2D/MX2/CFLAR/TRADD/FAS/CASP9/RIPK1/AKT2/GRB2/PPP2R2B/PPP2R1A/TICAM1/BAK1/TRAF3/CHUK	5.43153090489507
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	28/1305	78/9376	2.57911386187248	BTG2/CNOT6L/CNOT2/BTG1/PABPC1/PAN3/DDX6/CNOT4/TOB2/ZCCHC7/CNOT1/DHX36/TOB1/XRN1/HSPA9/TENT4B/XRN2/HSPD1/CNOT8/CNOT9/PABPC4/PNPT1/DCP1A/EXOSC10/EXOSC5/CNOT10/PATL1/MTREX	5.6310994408008
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	34/1305	106/9376	2.30451818116099	NFKB1/HSP90AA1/NFKBIA/ZEB1/BRAF/CDKN1B/LEF1/CREB1/CREBBP/FOXO1/BCL2/PIK3CD/TCF7/MAPK1/SOS1/SOS2/PIK3R1/RB1/HSP90AB1/GSK3B/TP53/EP300/PIK3CA/IKBKB/RAF1/MAP2K1/CTNNB1/IGF1R/PTEN/CASP9/AKT2/GRB2/SLC19A1/CHUK	5.43113280109003
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	47/1305	169/9376	1.99810469518692	PRKACB/PRKCQ/BIRC6/ERN1/DDIT4/BCL2/PIK3CD/ITPR1/RB1CC1/EIF2AK3/TANK/MAPK1/PIK3R1/ATG14/AMBRA1/UVRAG/MAPK8/RAB7A/PIK3CA/NRBF2/RAF1/C9orf72/HIF1A/MAP3K7/MAP2K1/PIK3C3/VPS41/BECN1/RRAS2/CFLAR/IGF1R/CTSD/PTEN/VMP1/IRS2/SQSTM1/AKT2/MTMR3/MTMR14/RUBCN/RPS6KB1/ATG4B/RPTOR/ATG7/PRKAA1/VPS39/UBC	5.26486936481534
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	35/1305	112/9376	2.24521072796935	NFKB1/JAK1/NFKBIA/STAT3/PIK3R5/SOCS1/HSPA8/TGFB1/CASP8/BCL2/IFNG/STAT1/MAPK1/TAB2/MAPK14/BIRC3/PIK3CG/MAPK8/IL10RA/IRAK4/GNAI3/IKBKB/MAP2K6/LDLR/GNAI2/CYCS/MAP3K7/BIRC2/TYK2/TAB1/HSPA6/CASP9/AKT2/MAP2K3/CHUK	5.33064562578714
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	25/1305	69/9376	2.60314287300794	FYN/RAC2/LCP2/PRKCA/PIK3CD/FCER1G/MAPK1/LAT/SOS1/SOS2/MAPK14/PIK3R1/MAPK8/ALOX5AP/PIK3CA/PLCG2/MAP2K6/MAP2K4/RAF1/MAP2K1/LYN/VAV1/AKT2/GRB2/MAP2K3	5.37426574451662
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	25/1305	71/9376	2.5298149047542	NFKB1/IRF1/STAT3/SOCS1/CCND2/STAT5B/PIK3CD/STAT1/MAPK1/SOS1/SOS2/MAPK14/PIK3R1/GSK3B/FOXO3/MAPK8/FOS/PIK3CA/SOCS3/RAF1/MAP2K1/CGA/AKT2/GRB2/SOCS5	5.20279954845792
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	32/1305	103/9376	2.23213183052487	PPP2R5C/PNN/PABPC1/SMG1/FUS/ACIN1/PCF11/EIF4A3/GSPT1/NXF1/WDR33/CPSF6/PAPOLG/PPP2R5A/CASC3/DAZAP1/PABPC4/PPP2R2A/WDR82/FIP1L1/NXT1/UPF3B/PPP2R2D/CPSF7/PPP1CB/RNGTT/SMG6/PPP2R5E/PPP2R2B/PPP2R3C/PPP2R1A/TARDBP	5.05583485952201
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	28/1305	86/9376	2.33919629332621	JUN/CBLB/PRKCB/BRAF/STAT5B/PRKCA/MYC/CDKN1B/CAMK2D/PIK3CD/MAPK1/SOS1/SOS2/CBL/PIK3R1/GSK3B/MAPK8/NCK2/PIK3CA/PLCG2/MAP2K4/AREG/RAF1/MAP2K1/NCK1/AKT2/GRB2/RPS6KB1	5.01663874023474
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	40/1305	144/9376	1.99574286930609	TRA2A/NFKB1/NFKBIA/TRA2B/LEF1/CASP8/FOXO1/TCF7/SIRT1/TAB2/MAPK14/GSK3B/FOXO3/MAPK8/LPIN2/IRAK4/MAP3K14/IKBKB/MAP2K6/MAP2K4/PRKAG2/C1QB/MAP3K7/CTNNB1/IL17RA/TAB1/LPIN1/C1QA/TRADD/FAS/RIPK1/AKT2/MAP2K3/ACADM/MAP3K5/TICAM1/PRKAA1/C1QC/TRAF3/CHUK	4.84181033995493
Organismal Systems	Immune system	hsa04611	Platelet activation	36/1305	126/9376	2.0527640941434	FYN/LCP2/APBB1IP/PRKACB/PIK3R5/ARHGEF1/ROCK1/RAP1B/PPP1R12A/PIK3CD/ITPR1/FCER1G/ORAI1/MAPK1/RASGRP1/RAP1A/MAPK14/PIK3R1/STIM1/PLCB1/PIK3CG/ITPR2/RASGRP2/GNAI3/FERMT3/PIK3CA/PLCG2/TLN1/GNAI2/ADCY7/LYN/PPP1CB/ROCK2/AKT2/GNA13/PLCB2	4.78379643608959
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	30/1305	98/9376	2.19939010086793	PIP4K2A/PRKCB/INPP4A/PRKCA/PIK3CD/ITPR1/DGKZ/PIK3R1/PLCB1/ITPKB/ITPR2/DGKD/PIK3CA/PLCG2/PIK3C2A/PI4K2B/IP6K1/IMPA1/PIK3C3/DGKA/IPMK/DGKE/PTEN/PI4KA/MTMR3/PI4KB/MTMR14/DGKQ/IP6K2/PLCB2	4.79925177535907
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	45/1305	173/9376	1.86884592385888	DNAJB1/NFKB1/JAK1/NFKBIA/CCND3/PRKCB/PRKCA/CREBBP/CASP8/PIK3CD/IFNG/STAT1/MAPK1/KPNA1/PIK3R1/NXF1/TNFSF10/NUP98/ICAM1/EP300/IRAK4/PIK3CA/IKBKB/SOCS3/RAF1/IFNAR1/KPNA5/CYCS/ADAR/MAP2K1/NXT1/TYK2/PYCARD/MX2/RAB11A/TRADD/DNAJC3/FAS/CASP9/PML/AKT2/TICAM1/BAK1/TRAF3/CHUK	4.63797420530497
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	44/1305	170/9376	1.85956276763579	ARID1B/PRKCB/TGFBR2/GADD45B/ARID2/BRAF/PRKCA/MYC/TGFB1/LEF1/PIK3CD/TCF7/NFE2L2/MAPK1/CSNK1A1/SMARCC1/SOS1/SOS2/PIK3R1/RB1/ARID1A/GSK3B/SMARCA2/TP53/SMAD3/SMARCC2/PBRM1/GSTA3/PIK3CA/PLCG2/SMAD2/RAF1/MAP2K1/CTNNB1/GSTT1/IGF1R/PTEN/FRAT2/APC/AKT2/GRB2/RPS6KB1/POLK/BAK1	4.54772077201124
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	33/1305	115/9376	2.06168915542229	AKAP13/PRKACB/PDE4D/PRKCB/NR4A2/ARHGEF1/BRAF/MEF2A/PRKCA/STK39/WNK1/CREB1/BCL2/JUND/ITPR1/ARRB2/MAPK1/PLCB1/ITPR2/PDE4B/EGR1/FOS/GNAI3/SGK1/GNAI2/RAF1/ADCY7/MAP2K1/RUNX2/ATF2/GNA13/PLCB2/OXSR1	4.60621897198782
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	45/1305	178/9376	1.81635025184037	JUN/RAC2/CCND3/NFATC3/PRKACB/CCDC88C/PRKCB/TLE4/CCND2/PRKCA/MYC/LEF1/NFATC2/CAMK2D/CREBBP/TBL1XR1/PPP3CA/PPP3CC/TCF7/SIRT1/CSNK1A1/PLCB1/GSK3B/TP53/EP300/MAPK8/SMAD3/RYK/INVS/SENP2/BTRC/CACYBP/CHD8/MAP3K7/TPTEP2-CSNK1E/CTNNB1/PSEN1/CTBP1/ROCK2/PPARD/FRAT2/APC/SIAH1/PLCB2/NFATC1	4.42147373983244
NA	NA	hsa04517	IgSF CAM signaling	67/1305	299/9376	1.60994374607568	FYN/CD96/MBP/CD48/MSN/ITGB2/ITGA4/LCK/LCP2/PRKCB/CASK/TUBA1A/SPTAN1/PRKCQ/PRKCA/RAP1B/ITGAL/IQGAP1/DOK2/CD2/FOXO1/PIK3CD/ICAM3/ICAM2/MAPK1/RAPGEF2/SH2D1A/TUBA4A/CSK/RAP1A/MAPK14/PIK3R1/PTPN6/SPTBN1/GSK3B/ACTR2/ICAM1/MAPK8/MYH9/LY9/ERC1/SLAMF6/MTSS1/JAML/ITGA5/NCK2/PIK3CA/PLCG2/CD226/ARPC4/CRTAM/MAP2K1/SLAMF7/CD28/CTNNB1/NCK1/LYN/NCAM1/VAV1/VCL/TUBB2A/ITGAM/AKT2/GRB2/CD244/PALS2/SH2D1B	4.31004127851824
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	28/1305	93/9376	2.16312775511886	JUN/PRKACB/PRKCB/PRKCA/CAMK2D/ITPR1/MAP3K2/MAPK1/SOS1/SOS2/MAPK14/PLCB1/ITPR2/EGR1/MAPK8/MAP3K1/MAP2K6/MAP2K4/RAF1/PTK2B/ADCY7/MAP2K1/CGA/MAP3K4/GRB2/MAP3K3/MAP2K3/PLCB2	4.53264742648393
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	44/1305	174/9376	1.81681419826485	HSPH1/DNAJB1/PPP1R15A/HSP90AA1/DNAJA1/DNAJC1/HSPA8/ERO1B/ERN1/BCL2/NGLY1/NFE2L2/EIF2AK3/UBE2G1/HSP90AB1/MOGS/MAPK8/MARCHF6/XBP1/UBE2G2/DDIT3/SEC31A/SEC23A/ATF6/UBE2D3/MAGT1/UBQLN1/UBE2D2/SEC24B/HSPA5/RRBP1/DNAJC3/HSPA6/MAN1A1/GANAB/SEC61A1/EDEM1/EDEM3/DNAJB11/MAN1C1/SEC63/DERL1/MAP3K5/BAK1	4.37304562358937
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	31/1305	108/9376	2.06226763161629	PNN/ACIN1/KPNA4/TPR/EIF4A3/KPNA1/POM121/POM121C/NXF1/NUP98/NUP210/THOC2/RANBP2/KPNA3/SENP2/CASC3/XPO6/KPNA5/KPNB1/NXT1/UPF3B/NUP107/XPO4/NUP153/NUP188/THOC1/NUP88/THOC3/TNPO3/NUP160/NUP50	4.46457408314045
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	25/1305	80/9376	2.24521072796935	JAK1/STAT3/PRKCB/BRAF/PRKCA/BCL2/PIK3CD/MAPK1/SOS1/SOS2/PIK3R1/EIF4E/GSK3B/FOXO3/PIK3CA/PLCG2/RAF1/MAP2K1/IGF1R/BCL2L11/PTEN/AKT2/GRB2/IL6R/RPS6KB1	4.49745689882502
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	31/1305	109/9376	2.0433477450877	JUN/NFKB1/JAK1/NFKBIA/CASP8/PIK3CD/STAT1/MAPK1/TAB2/MAPK14/PIK3R1/MAP3K8/MAPK8/FOS/IRAK4/SPP1/PIK3CA/IKBKB/MAP2K6/MAP2K4/IFNAR1/MAP3K7/MAP2K1/TYK2/TAB1/RIPK1/AKT2/MAP2K3/TICAM1/TRAF3/CHUK	4.40554832685437
Human Diseases	Cancer: specific types	hsa05214	Glioma	24/1305	76/9376	2.26884452510587	PRKCB/GADD45B/BRAF/PRKCA/CAMK4/CAMK2D/PIK3CD/MAPK1/SOS1/SOS2/PIK3R1/RB1/CAMK1D/TP53/PIK3CA/PLCG2/RAF1/MAP2K1/IGF1R/PTEN/AKT2/GRB2/POLK/BAK1	4.46581730579231
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	49/1305	205/9376	1.71731240071021	JUN/REL/NFKB1/JAK1/RASA2/NFKBIA/CCND3/PRKACB/STAT3/RBL2/CCND2/STAT5B/SP100/CDKN1B/CREB1/CREBBP/CASP8/PIK3CD/JAK3/MAPK1/GTF2B/PIK3R1/RB1/PMAIP1/MAPKAPK2/TP53/EP300/DDX3X/UBE3A/TBPL1/HDAC7/PIK3CA/TRAF1/POLB/HDAC3/DLG1/NFKB2/CHD4/TRAF5/LYN/HDAC4/TRADD/ATF2/USP7/HDAC1/GRB2/GTF2A1/BAK1/TRAF3	4.17545822580831
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	29/1305	101/9376	2.06292629262926	JUN/NFKB1/STAT3/PRKCB/TGFBR2/STAT5B/PRKCA/CDKN1B/TGFB1/FOXO1/BCL2/PIK3CD/STAT1/MAPK1/DIAPH1/MAPK14/PIK3R1/PLCB1/EGR1/ICAM1/PIM1/MAPK8/SMAD3/PIK3CA/PLCG2/SMAD2/AKT2/PLCB2/NFATC1	4.31851167517965
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	40/1305	157/9376	1.83049027503234	DUSP2/ELMO1/NFATC3/ODC1/ATP11B/TGFB1/PTGER4/NFATC2/ADAM10/CAMK2D/CREB1/GPR132/ATP8A1/SIRT1/MAPK1/MAPK14/PTPN6/MAPKAPK2/ARG2/VPS8/RAB7A/ADAM17/DUSP5/ATP2A2/SGK1/ATP2A3/C1QB/HIF1A/MAP2K1/SIRPG/CEBPB/VPS41/C1QA/PECAM1/PPARD/PLA2G6/DNMT3A/VPS39/NFATC1/C1QC	4.21958451963706
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	32/1305	116/9376	1.98197912537984	TXK/RAC2/RHOH/MSN/ITGB2/CYBA/ITGA4/CXCR4/PRKCB/ROCK1/PRKCA/RAP1B/ITGAL/ITK/PIK3CD/RASSF5/RAP1A/MAPK14/PIK3R1/ICAM1/GNAI3/PIK3CA/PLCG2/GNAI2/PTK2B/SIPA1/CTNNB1/VAV1/PECAM1/VCL/ROCK2/ITGAM	4.27910533671048
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	42/1305	168/9376	1.79616858237548	JAK1/IL2RG/CCND3/STAT3/IL7R/SOCS1/CCND2/STAT4/MCL1/STAT5B/MYC/CREBBP/BCL2/PIK3CD/IFNG/STAT1/JAK3/PTPN2/SOS1/SOS2/PIK3R1/PTPN6/PIAS1/PIM1/EP300/IL2RB/IL10RA/STAT6/PIAS2/PIK3CA/IL4R/SOCS3/RAF1/IFNAR1/IL12RB2/TYK2/IL21R/AKT2/GRB2/IL6R/SOCS5/IL12RB1	4.18701234933067
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	57/1305	250/9376	1.63810574712644	CBLB/CYTH1/SMAP2/WIPF1/IL2RG/CXCR4/BIN1/TGFBR2/SMURF2/ACAP2/HSPA8/IGF2R/ARAP2/SH3KBP1/ARRB2/GRK2/GRK5/USP8/VPS37B/CBL/CAPZA1/AP2B1/ACTR2/ARFGEF1/GIT2/IL2RB/RABEP1/GRK6/RAB7A/ARFGAP3/SMAD3/SNX1/WASHC4/SMAD2/GBF1/IST1/LDLR/ARPC4/RAB11FIP2/TFRC/SMAP1/CHMP1B/RAB11A/PDCD6IP/IGF1R/CYTH4/HSPA6/PML/WWP1/ARAP1/ARFGEF2/ASAP1/IQSEC1/ZFYVE16/RUFY2/ARFGAP2/WASHC1	4.11196726509527
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	23/1305	73/9376	2.26366451477458	CXCR4/MLLT3/AFF4/ELL2/CREBBP/SAMHD1/SERINC5/EP300/APOBEC3G/MDFIC/CPSF6/RANBP2/PSIP1/CCNT1/BST2/CPSF7/MX2/PDCD6IP/NUP153/BICD1/APOBEC3C/TNPO3/CCNT2	4.35821779985796
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	27/1305	93/9376	2.08587319243604	NFKB1/NFKBIA/GADD45B/MYC/CDKN1B/MAX/BCL2/PIK3CD/CKS2/PIK3R1/BIRC3/RB1/TP53/PIK3CA/TRAF1/IKBKB/FHIT/CYCS/BIRC2/TRAF5/PTEN/CASP9/AKT2/POLK/BAK1/TRAF3/CHUK	4.23159047621571
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	22/1305	70/9376	2.25804050355775	JUN/ETS1/BRAF/RAP1B/TGFB1/CREBBP/PIK3CD/MAPK1/RAP1A/SOS1/SOS2/PIK3R1/EP300/PIK3CA/PRCC/RAF1/HIF1A/MAP2K1/AKT2/GRB2/CUL2/VHL	4.2480472637869
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	27/1305	94/9376	2.06368305209098	JUN/NFKB1/HSP90AA1/TNFAIP3/NFKBIA/FOSB/CASP8/JUND/S100A9/IFNG/MAPK1/TAB2/MAPK14/HSP90AB1/GSK3B/MAPK8/FOS/IKBKB/USP25/MAP3K7/IL17RA/CEBPB/TRAF5/SRSF1/TRADD/TRAF3/CHUK	4.16756713645439
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	23/1305	75/9376	2.20330012771392	ATM/REV3L/CASP8/BCL2/PIK3CD/MAPK1/PIK3R1/BIRC3/PMAIP1/TP53/GSTA3/PIK3CA/MSH3/CYCS/BIRC2/GSTT1/FAS/TOP2B/CASP9/AKT2/MAP3K5/BAK1/ERCC1	4.20694653472281
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	26/1305	90/9376	2.07557258407833	NFKB1/PRKACB/SOD2/CAMK4/CREB1/FOXO1/PIK3CD/RB1CC1/SIRT1/PIK3R1/EIF4E/TP53/FOXO3/EHMT1/PIK3CA/ADCY7/PRKAG2/IGF1R/ATF2/IRS2/AKT2/SESN1/RPS6KB1/RPTOR/PRKAA1/SESN3	4.1226252524821
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	13/1305	32/9376	2.91877394636015	BIRC6/CASP8/BCL2/BIRC3/PMAIP1/MAPK8/CYCS/BIRC2/BECN1/BCL2L11/CASP9/HTRA2/BAK1	4.37179317278738
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	21/1305	67/9376	2.25191284954538	PRKACB/PRKCB/RPS6KA3/BRAF/PRKCA/RAP1B/CAMK4/CAMK2D/CREBBP/PPP3CA/PPP3CC/ITPR1/MAPK1/RAP1A/PLCB1/ITPR2/EP300/RAF1/MAP2K1/PPP1CB/PLCB2	4.1351113014854
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	70/1305	333/9376	1.5102919010965	ATM/NFKB1/IRF1/JAK1/ITGA4/PPP2R5C/CCND3/PRKACB/RBL2/CCND2/CDKN1B/MAML2/PTGER4/CREB1/CREBBP/CASP8/FOXO1/PIK3CD/TCF7/STAT1/MAPK1/CSNK1A1/SOS1/ATR/SOS2/PIK3R1/RB1/GSK3B/ISG15/TP53/EP300/MFNG/UBE3A/SPP1/ITGA5/TBPL1/PIK3CA/PPP2R5A/IKBKB/RAF1/IFNAR1/PPP2R2A/MAP2K1/CTNNB1/PSEN1/DLG1/CHD4/TYK2/PPP2R2D/MX2/TRADD/FAS/PTEN/PPP2R5E/APC/AKT2/HDAC1/NFX1/GRB2/LFNG/RPS6KB1/PPP2R2B/PPP2R3C/PPP2R1A/TADA3/TICAM1/BAK1/NOTCH1/TRAF3/CHUK	3.81251663556236
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	43/1305	181/9376	1.70685633242311	NFKB1/JAK1/ITGB2/CORO1A/TGFB1/CAMK2D/CREB1/CREBBP/CASP8/BCL2/PPP3CA/PPP3CC/MALT1/IFNG/CD74/FCER1G/STAT1/MAPK1/MAPK14/RIPK2/FCGR3A/EP300/MAPK8/HSPA9/IL10RA/RAB7A/IRAK4/NFYB/PLK3/HSPD1/CASP10/RAF1/CYCS/PIK3C3/CEBPB/TRADD/CTSS/CTSD/NFYC/ITGAM/CASP9/AKT2/NFYA	3.86119552371184
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	46/1305	200/9376	1.65247509578544	JUN/FYN/NFKB1/CYTH1/WIPF1/NFKBIA/ARHGEF1/TUBA1A/ROCK1/CASP8/ABI1/MAPK1/TUBA4A/TAB2/CYFIP2/MAPK14/MYO1F/PTPN6/TNFSF10/ACTR2/MAPK8/MYH9/FOS/IRAK4/NCK2/IKBKB/ARPC4/CYCS/NCKAP1L/MAP3K7/MYO1G/NCK1/PYCARD/TAB1/HCLS1/SEC24B/TRADD/CYTH4/ROCK2/FAS/TUBB2A/CASP9/RIPK1/GNA13/BAK1/CHUK	3.75041611044829
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	27/1305	99/9376	1.9594566353187	JUN/PRKACB/NCOR1/BRAF/CDKN1B/BCL2/PIK3CD/MAPK1/SOS1/SOS2/MAPK14/PIK3R1/RB1/TP53/MAPK8/FOS/NCOA3/PIK3CA/MED1/RAF1/ADCY7/MAP2K1/IGF1R/AKT2/GRB2/RPS6KB1/NOTCH1	3.85892546291102
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	38/1305	158/9376	1.72795964886755	ATM/ATRX/PPP2R5C/CCND3/RBL2/CCND2/GADD45B/STAG1/CDC14A/MYC/CCNH/CDKN1B/TGFB1/STAG2/CREBBP/PDS5A/NIPBL/ATR/RB1/E2F5/PDS5B/CDKN2D/GSK3B/TP53/EP300/SMAD3/WAPL/PPP2R5A/SMAD2/ORC2/ORC4/ANAPC1/CDC27/PPP2R5E/MAU2/HDAC1/PPP2R1A/CDC25B	3.71060494325269
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	20/1305	66/9376	2.177174039243	JUN/NFKB1/IL2RG/STAT3/RORA/STAT4/TGFB1/IFNG/STAT1/STAT6/SMAD3/IL4R/SMAD2/TBX21/IL12RB2/IL18RAP/IL21R/MAF/NFATC1/IL12RB1	3.85891332058281
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	46/1305	204/9376	1.62007362331906	MSN/PRKACB/STAT3/PRKCB/CD44/ARHGEF1/BRAF/ROCK1/DDX5/PRKCA/MYC/TGFB1/CAMK2D/IQGAP1/PPP1R12A/PIK3CD/ITPR1/MAPK1/SOS1/SOS2/MAPK14/CBL/PIK3R1/PTPN6/ITPR2/TP53/ITGA5/FLNA/PIK3CA/PLCG2/SMAD2/RAF1/HIF1A/MAP2K1/CTNNB1/HCLS1/VAV1/PPP1CB/RRAS2/IGF1R/ROCK2/FAS/AKT2/GRB2/RPS6KB1/EIF4B	3.60042309470967
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	19/1305	62/9376	2.20175503646026	PRKACB/SOD2/HSPA8/FOXO1/PIK3CD/SIRT1/PIK3R1/FOXO3/PIK3CA/ADCY7/PRKAG2/IGF1R/HSPA6/IRS2/AKT2/HDAC1/RPS6KB1/RPTOR/PRKAA1	3.81742839199836
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	35/1305	144/9376	1.74627501064283	PRKCB/RORA/PRKCA/ERN1/PIK3CD/ITPR1/RB1CC1/PUM2/ATXN2L/GTF2B/PIK3R1/ATG14/AMBRA1/PLCB1/PUM1/ATXN1/ITPR2/MAPK8/NOP56/XBP1/TBPL1/PIK3CA/PSMD12/NRBF2/ATP2A2/OPA1/ATP2A3/CYCS/PIK3C3/ATXN2/BECN1/AKT2/NFYA/MAP3K5/PLCB2	3.62877021203121
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	21/1305	72/9376	2.09553001277139	NFKB1/NFKBIA/CYLD/CASP8/TANK/MAPK14/RNF125/ISG15/MAPK8/DDX3X/MAP3K1/ZNFX1/IKBKB/CASP10/ADAR/MAP3K7/OTUD5/TRADD/RIPK1/TRAF3/CHUK	3.75217337639274
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	22/1305	78/9376	2.02644660575695	JUN/NFKB1/JAK1/ITGB2/CYBA/ITGA4/NFKBIA/MARCKSL1/PRKCB/TGFB1/IFNG/STAT1/MAPK1/TAB2/MAPK14/PTPN6/FCGR3A/FOS/IRAK4/MAP3K7/TAB1/ITGAM	3.66029521192095
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	32/1305	130/9376	1.7685352195697	JUN/NFKB1/GNG2/NFKBIA/PRKACB/TGFBR2/PRKCA/TGFB1/CREB1/PIK3CD/ARRB2/MAPK1/SOS1/SOS2/MAPK14/PIK3R1/PLCB1/MAPK8/FOS/GNAI3/PIK3CA/SMAD2/MAP2K4/GNAI2/RAF1/ADCY7/MAP2K1/GNB5/ATF2/AKT2/GRB2/PLCB2	3.54801728258578
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	28/1305	109/9376	1.84560441491792	NFKB1/NFKBIA/STAT3/PRKCB/RPS6KA3/PRKCQ/OGT/CREB1/FOXO1/PIK3CD/OGA/PIK3R1/GSK3B/MAPK8/TBC1D4/PIK3CA/IKBKB/SOCS3/MLXIP/PRKAG2/PPP1CB/SLC27A4/PTEN/IRS2/AKT2/RPS6KB1/CRTC2/PRKAA1	3.57057475119111
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	26/1305	99/9376	1.88688416734394	JUN/RAC2/GPCPD1/PRKCB/PRKCA/PIK3CD/DGKZ/MAPK1/SOS1/SOS2/PIK3R1/MAPK8/FOS/DGKD/WAS/PIK3CA/RALGDS/RAF1/HIF1A/MAP2K1/DGKA/DGKE/AKT2/GRB2/RPS6KB1/DGKQ	3.56703968687373
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	34/1305	142/9376	1.72027413523285	JUN/KLF2/NFKB1/RAC2/CYBA/HSP90AA1/MEF2A/BCL2/PIK3CD/DUSP1/IFNG/NFE2L2/MAPK14/PIK3R1/HSP90AB1/ICAM1/TP53/MAPK8/FOS/GSTA3/PIK3CA/IKBKB/MAP2K6/MAP2K4/MAP3K7/CTNNB1/MAP2K5/GSTT1/PECAM1/SQSTM1/AKT2/MAP3K5/PRKAA1/CHUK	3.47755716024082
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	28/1305	110/9376	1.82882619296412	NFKB1/STAT3/PRKCB/PRKCA/CDKN1B/CAMK2D/CREBBP/BCL2/PIK3CD/IFNG/MAPK1/MKNK2/PIK3R1/EIF4E/EP300/PIK3CA/PLCG2/HIF1A/MAP2K1/TFRC/PGK1/IGF1R/AKT2/CUL2/IL6R/RPS6KB1/PFKFB3/VHL	3.515935363238
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/1305	37/9376	2.52434503468986	GADD45B/BRAF/MYC/LEF1/TPR/TCF7/MAPK1/TP53/MAP2K1/CTNNB1/TPM3/POLK/BAK1	3.7356069538414
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	18/1305	60/9376	2.15540229885057	RAC2/PRKCB/PRKCA/NFATC2/PIK3CD/PPP3CA/PPP3CC/MAPK1/MAPK14/PIK3R1/MAPKAPK2/PIK3CA/PLCG2/RAF1/SH2D2A/MAP2K1/CASP9/AKT2	3.6101174638039
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	33/1305	138/9376	1.71807429618524	CBLB/PDE3B/PRKACB/SOCS1/BRAF/FOXO1/PIK3CD/MAPK1/SOS1/SOS2/MKNK2/CBL/PIK3R1/EIF4E/GSK3B/MAPK8/PRKAR1A/PIK3CA/IKBKB/SOCS3/RAF1/PRKAG2/MAP2K1/PRKAR2A/PPP1CB/IRS2/RHOQ/AKT2/GRB2/RPS6KB1/RPTOR/PRKAA1/PRKAR1B	3.41701720764378
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	32/1305	133/9376	1.72864344769971	GNG2/PPP2R5C/PRKACB/PRKCB/PRKCA/CAMK2D/CREB1/PPP3CA/PPP3CC/ITPR1/ARRB2/MAPK14/PLCB1/GSK3B/ITPR2/MAPK8/FOS/GNAI3/PPP2R5A/GNAI2/PPP2R2A/PPP2R2D/GNB5/PPP1CB/ATF2/PPP2R5E/AKT2/CLOCK/PPP2R2B/PPP2R3C/PPP2R1A/PLCB2	3.40299748575835
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	13/1305	38/9376	2.45791490219802	PTPRC/IL2RG/LCK/IL7R/CD3E/ZAP70/CD3D/ORAI1/JAK3/ADA/ICOS/CD8B/CD8A	3.62096443367539
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	33/1305	140/9376	1.69353037766831	KLF2/GNG2/PDE3B/PRKACB/PIK3R5/MEF2A/CAMK4/ITPR1/MAPK1/PLCB1/PIK3CG/ITPR2/EGR1/SMAD3/GNAI3/SPP1/SMAD2/GNAI2/RAF1/ADCY7/PRKAG2/MAP2K1/PIK3C3/GNB5/BECN1/RRAS2/HDAC4/AKT2/RPS6KB1/NRF1/GNA13/PLCB2/PRKAA1	3.32441141346489
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	36/1305	158/9376	1.63701440419031	PRKCB/RICTOR/RPS6KA3/BRAF/PRKCA/DDIT4/PIK3CD/MAPK1/SOS1/SOS2/PIK3R1/EIF4E/GSK3B/LPIN2/CAB39/PIK3CA/IKBKB/SGK1/RAF1/PRR5L/MAP2K1/MAPKAP1/SLC7A5/TELO2/LPIN1/IGF1R/FNIP1/PTEN/AKT2/MIOS/GRB2/RPS6KB1/EIF4B/RPTOR/PRKAA1/CHUK	3.24703271780083
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	24/1305	93/9376	1.85410950438759	FYN/RAC2/TGFBR2/SMURF2/ROCK1/RAP1B/LEF1/CREBBP/IQGAP1/TCF7/MAPK1/CCM2/RAP1A/PTPN6/EP300/PTPRJ/SMAD3/WAS/YES1/MAP3K7/CTNNB1/IGF1R/VCL/ROCK2	3.32841962541103
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	21/1305	78/9376	1.93433539640436	PIP4K2A/INPP4A/PIK3CD/PLCB1/PIK3CG/ITPKB/PIK3CA/PLCG2/PIK3C2A/PI4K2B/IP6K1/IMPA1/PIK3C3/IPMK/PTEN/PI4KA/MTMR3/PI4KB/MTMR14/IP6K2/PLCB2	3.33182784044097
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	14/1305	44/9376	2.28603274120515	CCNH/TAF7/GTF2B/TAF3/TAF1/TAF15/GTF2I/TBPL1/TAF2/TAF4B/TAF5L/MNAT1/ERCC3/GTF2A1	3.43809774124964
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	35/1305	154/9376	1.63288052943225	PPP2R5C/PRKACB/PIK3R5/PRKCA/ATP2B1/CAMK2D/CREB1/BCL2/RPS6KA5/MAPK1/CREM/ATP1A1/MAPK14/PLCB1/PIK3CG/GNAI3/PPP2R5A/ATP2A2/GNAI2/ATP2A3/ADCY7/PPP2R2A/ATP2B4/PPP2R2D/ADRB2/PPP1CB/ATF2/TPM3/PPP2R5E/AKT2/PPP2R2B/ATP1B3/PPP2R3C/PPP2R1A/PLCB2	3.18417374209443
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	37/1305	166/9376	1.60140331440705	PDE3B/NFATC3/PIK3R5/ROCK1/MEF2A/ATP2B1/NFATC2/CREB1/PPP1R12A/PPP3CA/PPP3CC/ITPR1/MAPK1/ATP1A1/PLCB1/PIK3CG/ITPR2/GNAI3/GTF2I/ATP2A2/GNAI2/RAF1/ATP2A3/ADCY7/MAP2K1/ATP2B4/ADRB2/PPP1CB/RGS2/ATF2/ROCK2/IRS2/AKT2/GNA13/ATP1B3/PLCB2/NFATC1	3.14352751850064
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	45/1305	212/9376	1.52504879635654	FYB1/SKAP1/RAC2/ITGB2/EVL/LCP2/APBB1IP/PRKCB/BRAF/PRKCA/RAP1B/ITGAL/SIPA1L1/PRKD3/PIK3CD/MAPK1/RAPGEF2/RASSF5/RAP1A/LAT/MAPK14/PIK3R1/PLCB1/RASGRP2/RGS14/GNAI3/PIK3CA/PRKD2/MAP2K6/RALGDS/TLN1/GNAI2/RAF1/ADCY7/SIPA1/MAP2K1/CTNNB1/SIPA1L3/VAV1/IGF1R/ITGAM/AKT2/MAP2K3/PLCB2/RALA	3.10922590764832
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	71/1305	368/9376	1.38617357987673	MT-CO1/MT-CO2/MT-CO3/MT-ATP6/MT-CYB/MT-ND4/TUBA1A/MT-ND1/MT-ND2/FUS/SRSF7/ERN1/BCL2/MT-ND5/PPP3CA/PPP3CC/RB1CC1/TPR/EIF2AK3/TANK/ATXN2L/TUBA4A/TNFRSF1B/DCTN4/MAPK14/SETX/POM121/POM121C/ATG14/NXF1/AMBRA1/NUP98/NUP210/TP53/SPG11/RANBP2/SDHA/XBP1/MAP2K6/HNRNPA1L3/PSMD12/NRBF2/GPX7/DDIT3/CYCS/C9orf72/ATF6/NXT1/UBQLN1/PIK3C3/ATXN2/NUP107/VAPB/MT-ND6/HSPA5/BECN1/NUP153/NUP188/TUBB2A/CASP9/SQSTM1/ACTR1B/NUP88/NUP160/MAP2K3/DERL1/NUP50/MAP3K5/TARDBP/SRSF3/MT-ND4L	3.03892162154905
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	70/1305	362/9376	1.38930166592578	NR4A1/NFKB1/JAK1/HSP90AA1/GNG2/ITGA4/IL2RG/PPP2R5C/CCND3/PIK3R5/IL7R/RBL2/CCND2/MCL1/PRKCA/MYC/CDKN1B/CREB1/DDIT4/BCL2/PIK3CD/LPAR6/JAK3/MAPK1/SOS1/SOS2/PIK3R1/HSP90AB1/PIK3CG/EIF4E/GSK3B/TP53/FOXO3/IL2RB/CDC37/PKN1/PKN2/SPP1/ITGA5/PIK3CA/PPP2R5A/IL4R/IKBKB/AREG/SGK1/RAF1/IFNAR1/PPP2R2A/MAP2K1/PPP2R2D/GNB5/IGF1R/ATF2/BCL2L11/FLT3LG/PTEN/PPP2R5E/CASP9/AKT2/GRB2/IL6R/RPS6KB1/PPP2R2B/EIF4B/PPP2R3C/PPP2R1A/CRTC2/RPTOR/PRKAA1/CHUK	3.03744897397305
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	32/1305	139/9376	1.6540257449213	JUN/HSP90AA1/FKBP5/PRKACB/NCOA1/HSPA8/CREB1/BCL2/PIK3CD/ITPR1/MAPK1/SOS1/SOS2/PIK3R1/HSP90AB1/PLCB1/ITPR2/FOS/NCOA3/GNAI3/PIK3CA/GNAI2/RAF1/ADCY7/NCOA2/MAP2K1/ATF2/CTSD/HSPA6/AKT2/GRB2/PLCB2	3.12366170145983
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	28/1305	117/9376	1.71940924124832	EPC1/ARID1B/ARID2/BPTF/CHD3/RSF1/BAZ2B/BAZ1A/BAZ2A/SMARCC1/INO80/ARID1A/TRRAP/SMARCA2/SMARCC2/PBRM1/MTA2/SMARCA5/SS18/DPF2/CHD4/GATAD2B/GATAD2A/RBBP4/EP400/MEAF6/HDAC1/BRD9	3.14857557067659
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	21/1305	82/9376	1.83997757218951	HSP90AA1/HSPA4/HSPA8/CREB1/IFNG/CD74/KLRD1/B2M/HSP90AB1/NFYB/KLRC1/HSPA5/CD8B/CTSS/KLRC2/HSPA6/NFYC/CD8A/NFYA/TAPBP/TAPBPL	3.07185352096041
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	24/1305	98/9376	1.75951208069435	PTPRC/RAC2/MARCKSL1/BIN1/PRKCB/PRKCA/PIK3CD/MAPK1/LAT/PIK3R1/FCGR3A/ACTR2/WAS/PIK3CA/PLCG2/ARPC4/RAF1/MAP2K1/LYN/VAV1/PLA2G6/AKT2/ASAP1/RPS6KB1	3.03911938162675
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	24/1305	98/9376	1.75951208069435	NR4A1/PRKACB/PRKCB/NR4A2/PRKCA/ATP2B1/CAMK4/CAMK2D/CREB1/PRKD3/ITPR1/ORAI1/ATP1A1/PLCB1/CAMK1D/ITPR2/ATF1/PRKD2/LDLR/ADCY7/ATP2B4/ATF2/ATP1B3/PLCB2	3.03911938162675
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	33/1305	148/9376	1.60198819509164	JUN/GADD45B/BRAF/MYC/NCOA1/LEF1/PIK3CD/TCF7/MAPK1/CSNK1A1/SOS1/SOS2/PIK3R1/RB1/GSK3B/TP53/FOS/NCOA3/PIK3CA/RAF1/MAP2K1/CTNNB1/NFKB2/IGF1R/PTEN/FRAT2/APC/AKT2/GRB2/RPS6KB1/POLK/BAK1/NOTCH1	2.96819384408801
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	34/1305	154/9376	1.5862268000199	JUN/NFATC3/PRKACB/PIK3R5/PRKCB/ROCK1/PRKCA/NFATC2/CAMK4/CAMK2D/PPP1R12A/PPP3CA/PPP3CC/ITPR1/CD38/MAPK1/PLCB1/PIK3CG/CAMK1D/ITPR2/FOS/GNAI3/GNAI2/RAF1/ADCY7/PRKAG2/MAP2K1/MAP2K5/PPP1CB/RGS2/ROCK2/PLCB2/PRKAA1/NFATC1	2.9494476393672
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	27/1305	115/9376	1.68683658170915	FYN/GNG2/PRKACB/PIK3R5/PRKCB/PRKCA/CAMK4/CAMK2D/CREB1/BCL2/PIK3CD/ITPR1/MAPK1/PIK3R1/PLCB1/PIK3CG/ITPR2/FOS/KCNQ5/GNAI3/PIK3CA/GNAI2/ADCY7/MAP2K1/GNB5/AKT2/PLCB2	2.97989263351339
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	33/1305	149/9376	1.59123659646687	FYN/CYTH1/PIK3R5/PRKCA/PIK3CD/DGKZ/FCER1G/LPAR6/MAPK1/SOS1/SOS2/PIK3R1/PLCB1/PIK3CG/AGPAT4/DGKD/PIK3CA/PLCG2/RALGDS/RAF1/PTK2B/ADCY7/MAP2K1/DGKA/RRAS2/CYTH4/DGKE/AKT2/GRB2/DGKQ/GNA13/PLCB2/RALA	2.92517196545009
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	22/1305	89/9376	1.77598691291059	PRKACB/PRKCB/TUBA1A/PRKCA/ITPR1/MAP3K2/MAPK1/TUBA4A/SOS1/SOS2/PLCB1/ITPR2/CSNK1D/GNAI3/GNAI2/RAF1/ADCY7/MAP2K1/MAP2K5/TUBB2A/GRB2/PLCB2	2.95759632437455
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	17/1305	63/9376	1.93872164446877	KMT2E/KMT2C/SMYD3/ASH1L/SETD2/PRDM2/NSD1/KMT2A/EZH2/EHMT1/NSD3/CAMKMT/PHYKPL/KMT2B/SETD1B/EZH1/GCDH	3.00600380034953
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	42/1305	203/9376	1.48648434403488	JUN/FYN/RAC2/ITGA4/CCND3/PRKCB/CCND2/BRAF/ROCK1/PRKCA/RAP1B/PPP1R12A/BCL2/PIK3CD/MAPK1/DIAPH1/RAP1A/SOS1/SOS2/PIK3R1/BIRC3/GSK3B/MAPK8/SPP1/ITGA5/FLNA/PIK3CA/TLN1/RAF1/MAP2K1/BIRC2/CTNNB1/VAV1/PPP1CB/IGF1R/VCL/ROCK2/PTEN/ILK/AKT2/GRB2/PARVG	2.81765886015402
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/1305	34/9376	2.32445345954474	CRY1/RORA/CREB1/PER1/CSNK1D/BTRC/NFIL3/PRKAG2/TPTEP2-CSNK1E/CLOCK/PRKAA1	3.11088136576451
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	19/1305	75/9376	1.82011749680715	ATM/CCND3/CCND2/GADD45B/CASP8/BCL2/ATR/PMAIP1/COP1/TP53/MDM4/CYCS/FAS/PTEN/CASP9/SESN1/SIAH1/SESN3/PPM1D	2.86727341067703
Organismal Systems	Nervous system	hsa04730	Long-term depression	16/1305	60/9376	1.91591315453384	PRKCB/BRAF/PRKCA/ITPR1/MAPK1/PLCB1/ITPR2/GNAI3/GNAI2/RAF1/MAP2K1/LYN/IGF1R/GNA13/PPP2R1A/PLCB2	2.86182057781934
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	46/1305	232/9376	1.42454749636676	RAC2/MSN/ITGB2/ITGA4/CXCR4/PIP4K2A/SSH2/TMSB4X/ARHGEF1/BRAF/ROCK1/RGCC/IQGAP2/ITGAL/FGD3/IQGAP1/PPP1R12A/PIK3CD/MAPK1/DIAPH1/CYFIP2/SOS1/SOS2/PIK3R1/ACTR2/CYRIB/MYH9/ARHGEF6/ARHGEF7/SPATA13/ITGA5/PIK3CA/ARPC4/RAF1/ITGAE/NCKAP1L/MAP2K1/VAV1/PPP1CB/RRAS2/VCL/ROCK2/ITGAM/APC/AKT2/GNA13	2.63286983169259
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/1305	56/9376	1.92446633825944	MGAT4A/MGAT5/ST6GAL1/B4GALT1/MAN2A1/MOGS/ALG13/MAGT1/ALG3/DPM1/MAN1A1/GANAB/MAN1C1/ALG6/DHRSX	2.79000113486005
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	15/1305	56/9376	1.92446633825944	PRKACB/SMURF2/CCND2/SPOP/BCL2/ARRB2/GRK2/CSNK1A1/GSK3B/CSNK1D/BTRC/CSNK1G2/CSNK1G3/CUL3/TPTEP2-CSNK1E	2.79000113486005
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	15/1305	56/9376	1.92446633825944	NFKB1/CLK1/ITGB2/NFKBIA/HSPA8/CASP8/CLK4/HSPD1/CYCS/NFKB2/PYCARD/HSPA6/ITGAM/CASP9/BCL2L13	2.79000113486005
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	45/1305	227/9376	1.42427464681756	JUN/NFKB1/MT-CO1/CYBA/MT-CO2/MT-CO3/NFKBIA/MT-ATP6/MT-CYB/MT-ND4/BRAF/SOD2/MT-ND1/MT-ND2/PRKD3/PIK3CD/MT-ND5/NFE2L2/MAPK1/SOS1/SOS2/MAPK14/PIK3R1/FOXO3/MAPK8/PTPRJ/FOS/SDHA/GSTA3/MAP3K14/PIK3CA/IKBKB/PRKD2/MAP2K4/RAF1/HIF1A/MAP2K1/GSTT1/MT-ND6/PTEN/AKT2/GRB2/MAP3K5/MT-ND4L/CHUK	2.60195880135994
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	32/1305	150/9376	1.53273052362708	TGFBR2/GADD45B/BRAF/MYC/CDKN1B/TGFB1/LEF1/BCL2/PIK3CD/TCF7/MAPK1/CSNK1A1/SOS1/SOS2/PIK3R1/RB1/GSK3B/TP53/SMAD3/PIK3CA/SMAD2/RAF1/ABCB1/MAP2K1/CTNNB1/FRAT2/APC/AKT2/GRB2/RPS6KB1/POLK/BAK1	2.64468350093416
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	23/1305	99/9376	1.66916676341964	PRKCH/PRKACB/PRKCB/PRKCQ/PRKCA/PTGER4/CAMK2D/PIK3CD/ITPR1/MAPK14/PIK3R1/PLCB1/ITPR2/MAPK8/PIK3CA/PLCG2/MAP2K6/ADCY7/PPP1CB/PLA2G6/MAP2K3/PLCB2/TRPV2	2.69138235876188
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	24/1305	105/9376	1.64221127531472	JUN/ARIH1/USP15/SMURF2/EIF2AK3/USP8/HUWE1/AMBRA1/CITED2/TP53/FOXO3/MAPK8/RAB7A/OPA1/RHOT2/HIF1A/SAMM50/TBC1D15/BECN1/RRAS2/SQSTM1/SIAH1/UBC/BCL2L13	2.66094872238631
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	27/1305	122/9376	1.59005087620124	PPP2R5C/CREB1/FOXO1/PIK3CD/SIRT1/PIK3R1/FOXO3/CAB39/TBC1D1/PIK3CA/PPP2R5A/PPP2R2A/PRKAG2/MAP3K7/PPP2R2D/IGF1R/PPP2R5E/IRS2/AKT2/RPS6KB1/PFKFB3/PPP2R2B/PPP2R3C/PPP2R1A/CRTC2/RPTOR/PRKAA1	2.63773916487891
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	33/1305	157/9376	1.51015447690168	JUN/NFKB1/MT-CO1/MT-CO2/MT-CO3/MT-CYB/TGFB1/CASP8/ERN1/PIK3CD/EIF2AK3/MAPK14/PIK3R1/GSK3B/MAPK8/FOS/SDHA/XBP1/PIK3CA/IKBKB/SOCS3/MLXIP/DDIT3/CYCS/PRKAG2/FAS/BCL2L11/IRS2/AKT2/IL6R/MAP3K11/MAP3K5/PRKAA1	2.5920110061181
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	44/1305	226/9376	1.39878615264639	JUN/NFKB1/RAC2/NFKBIA/PDE3B/PRKACB/PDE4D/BRAF/ROCK1/RAP1B/ATP2B1/CAMK4/CAMK2D/CREB1/CREBBP/PPP1R12A/PIK3CD/ORAI1/MAPK1/RAP1A/ATP1A1/PIK3R1/PDE4B/EP300/MAPK8/FOS/GNAI3/PIK3CA/ATP2A2/GNAI2/RAF1/ATP2A3/ADCY7/MAP2K1/ATP2B4/ADRB2/VAV1/PPP1CB/RRAS2/CGA/ROCK2/AKT2/ATP1B3/NFATC1	2.44011875227969
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	34/1305	168/9376	1.45404123335158	JAK1/HSP90AA1/TNFAIP3/STAT3/STAT4/CYLD/STAT5B/CAMK2D/CASP8/BCL2/IFNG/STAT1/JAK3/BIRC3/HSP90AB1/TNFSF10/MAPK8/STAT6/TRPM7/IFNAR1/BIRC2/TYK2/PYCARD/SPATA2L/TRAF5/CHMP1B/DNM1L/CFLAR/TRADD/FAS/SQSTM1/RIPK1/AIFM1/TICAM1	2.38778104691881
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	16/1305	65/9376	1.7685352195697	PRKCB/PRKCA/PIK3CD/ITPR1/ARRB2/MAPK1/PIK3R1/PLCB1/ITPR2/SPP1/PIK3CA/RAF1/MAP2K1/CGA/AKT2/PLCB2	2.50005469482193
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	42/1305	217/9376	1.39058212829069	JUN/NFKB1/HSP90AA1/CCND3/PRKACB/STAT3/PRKCB/RPS6KA3/STAT5B/PRKCA/MYC/CREB1/BCL2/PIK3CD/KPNA4/ARRB2/MAPK1/AIP/SOS1/SOS2/KPNA1/PIK3R1/RB1/HSP90AB1/FOS/BCL6/GNAI3/KPNA3/GSTA3/PIK3CA/GNAI2/RAF1/KPNA5/ADCY7/MAP2K1/KPNB1/GSTT1/ADRB2/ATF2/AKT2/GRB2/RPS6KB1	2.34069822266056
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	24/1305	110/9376	1.56756530825496	TGFBR2/SMURF2/NCOR1/ROCK1/MYC/TGFB1/CREBBP/IFNG/ID2/MAPK1/E2F5/SKIL/LEMD3/EP300/EMP3/SMAD3/SMAD2/TFRC/SMAD7/NOG/HDAC1/RPS6KB1/ZFYVE16/PPP2R1A	2.40764946279524
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	24/1305	110/9376	1.56756530825496	HSP90AA1/PDE3B/PRKACB/STK10/RPS6KA3/BRAF/PIK3CD/MAPK1/MAPK14/PIK3R1/HSP90AB1/MAPK8/GNAI3/PIK3CA/GNAI2/RAF1/ADCY7/MAP2K1/ANAPC1/IGF1R/CDC27/AKT2/CPEB2/CDC25B	2.40764946279524
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	40/1305	205/9376	1.40188767404915	NFKB1/RAC2/MT-CO1/CYBA/MT-CO2/MT-CO3/MT-ATP6/PRKCB/MT-CYB/TGFBR2/MT-ND4/PRKCA/MT-ND1/TGFB1/MT-ND2/CAMK2D/PIK3CD/MT-ND5/PDK3/MAPK14/PIK3R1/PLCB1/GSK3B/MAPK8/TBC1D4/SMAD3/SDHA/PIK3CA/SMAD2/ATP2A2/ATP2A3/MPC1/MT-ND6/PPP1CB/CTSD/PTEN/AKT2/PLCB2/GSR/MT-ND4L	2.33937848111653
Genetic Information Processing	Transcription	hsa03040	Spliceosome	46/1305	243/9376	1.36006180723082	TRA2A/PRPF38B/SF1/SRSF6/DDX5/TRA2B/HSPA8/FUS/SRSF7/ACIN1/RBMX/EIF4A3/TCERG1/RBM25/SRSF10/SF3B1/THOC2/SRSF2/PRPF40A/CASC3/HNRNPA1L3/HNRNPU/SRSF4/BCAS2/CDC40/PRPF38A/CDC5L/HNRNPC/AQR/DHX38/DDX46/PPIE/U2SURP/SF3B4/RBM22/SRSF1/PRPF18/HSPA6/THOC1/SLU7/DDX23/THOC3/SNIP1/U2AF2/U2AF1L4/SRSF3	2.28665521135073
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	83/1305	480/9376	1.24234993614304	NFKB1/MT-CO1/MT-CO2/MT-CO3/MT-ATP6/PRKCB/MT-CYB/MT-ND4/TUBA1A/BRAF/PRKCA/MT-ND1/MT-ND2/CAMK2D/CASP8/FUS/ERN1/BCL2/MT-ND5/PPP3CA/PPP3CC/ITPR1/RB1CC1/EIF2AK3/TANK/MAPK1/ATXN2L/CSNK1A1/UBE2G1/TUBA4A/TNFRSF1B/DCTN4/MAPK14/ATG14/AMBRA1/PLCB1/ATXN1/GSK3B/ITPR2/MAPK8/SPG11/SDHA/XBP1/UBE2G2/MAP2K6/PSMD12/NRBF2/ATP2A2/GPX7/DDIT3/RAF1/ATP2A3/CYCS/C9orf72/ATF6/MAP2K1/TPTEP2-CSNK1E/CTNNB1/PSEN1/PIK3C3/ATXN2/VAPB/HTT/MT-ND6/HSPA5/BECN1/TRAP1/FAS/TUBB2A/FRAT2/CASP9/SQSTM1/ACTR1B/APC/MAP2K3/HTRA2/DERL1/MAP3K5/PLCB2/UBC/BAK1/TARDBP/MT-ND4L	2.1917618413412
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	18/1305	78/9376	1.6580017683466	JUN/NFKB1/IRF1/ITGB2/MAPK1/MAPK14/MAPK8/FOS/IRAK4/GNAI3/ITGA5/GNAI2/C1QB/PYCARD/C1QA/ITGAM/TICAM1/C1QC	2.34642572600105
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	29/1305	144/9376	1.44691358024691	KAT6A/JAK1/STAT3/MYC/JARID2/PCGF5/PIK3CD/TCF7/ID2/JAK3/MAPK1/MAPK14/PIK3R1/SKIL/GSK3B/SMAD3/PIK3CA/SMAD2/RAF1/MAP2K1/CTNNB1/REST/TCF3/IGF1R/RIF1/APC/SMARCAD1/AKT2/GRB2	2.17312205852274
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	44/1305	238/9376	1.32825911973985	REL/NFKB1/RAC2/STK4/ETS1/RASA2/GNG2/PRKACB/RALGAPA1/PRKCB/PRKCA/RAP1B/ZAP70/PIK3CD/MAPK1/RASGRP1/RASAL3/RASSF5/RAP1A/LAT/SOS1/SOS2/PIK3R1/RASGRP2/MAPK8/RASSF1/EXOC2/SHOC2/PIK3CA/IKBKB/PLCG2/RALGDS/RAF1/RALGAPA2/MAP2K1/GNB5/RRAS2/IGF1R/FLT3LG/PLA2G6/AKT2/GRB2/RALA/CHUK	2.06256157460166
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	16/1305	70/9376	1.64221127531472	NFKB1/NFKBIA/STAT3/PRKCQ/TNFRSF1B/MAPK8/NFKBIE/IKBKB/SOCS3/PRKAG2/TRADD/IRS2/AKT2/PRKAA1/ACSL3/CHUK	2.16856599064863
NA	NA	hsa04518	Integrin signaling	30/1305	154/9376	1.3996118823705	RAC2/ITGB2/ITGA4/CCND3/CCND2/TGFB1/ITGAL/PIK3CD/ICAM3/ICAM2/PIK3R1/GSK3B/ICAM1/ARHGEF6/SPP1/ITGA5/FLNA/FERMT3/NCK2/PIK3CA/TLN1/ITGAE/CTNNB1/IGF1R/VCL/LIMS1/ITGAM/ILK/AKT2/PARVG	2.01054322845824
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	22/1305	107/9376	1.47722275933684	PDE3B/PRKACB/CAMK2D/CREB1/CREBBP/FOXO1/PPP3CA/PPP3CC/ITPR1/SIRT1/SIK1/SIK2/PLCB1/ITPR2/EP300/PPP4R3A/PRKAG2/ATF2/AKT2/CRTC2/PLCB2/PRKAA1	1.99629084765137
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	14/1305	62/9376	1.62234581633914	TLE4/MAML2/CREBBP/SPEN/ATXN1/EP300/MFNG/ADAM17/NUMB/PSEN1/CTBP1/HDAC1/LFNG/NOTCH1	1.9769092010067
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	15/1305	69/9376	1.56188572380476	JUN/PRKACB/PRKCB/FOSB/PRKCA/CAMK4/CAMK2D/CREB1/PPP3CA/PPP3CC/SIRT1/FOS/PPP1CB/ATF2/HDAC1	1.88362699832925
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	16/1305	75/9376	1.53273052362708	PRKACB/PRKCB/PRKCA/CREB1/ITPR1/ATP1A1/PLCB1/ITPR2/GPX7/ADCY7/HSPA5/ATF2/CGA/ATP1B3/PLCB2/GSR	1.86251856764269
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	29/1305	155/9376	1.344229390681	NR4A1/PRKACB/BRAF/RAP1B/CDKN1B/LEF1/CAMK2D/CREB1/ITPR1/TCF7/ORAI1/KMT2A/MAPK1/AIP/USP8/RAP1A/RB1/PLCB1/GSK3B/ITPR2/GNAI3/LDLR/GNAI2/ADCY7/MAP2K1/CTNNB1/ATF2/APC/PLCB2	1.73760879679564
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	20/1305	100/9376	1.43693486590038	CD7/ITGA4/CD37/IL7R/CD3E/CD44/CD3G/CD3D/CD2/CD38/ITGA5/IL4R/CD55/TFRC/CD5/CD8B/FLT3LG/ITGAM/CD8A/IL6R	1.76629626955073
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	29/1305	157/9376	1.32710544939844	ITGB2/CCND3/TGFBR2/CCND2/MYC/TGFB1/LEF1/TCF7/ID2/BIRC3/GSK3B/RASSF1/SMAD3/CSNK1D/BTRC/SMAD2/AREG/PPP2R2A/TPTEP2-CSNK1E/BIRC2/CTNNB1/DLG1/TP53BP2/SMAD7/PPP2R2D/PPP1CB/APC/PPP2R2B/PPP2R1A	1.66196899839297
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	9/1305	38/9376	1.7016333938294	PRKCB/PRKCA/PIK3CD/MAPK1/ATP1A1/PIK3R1/PIK3CA/SGK1/ATP1B3	1.74261855798641
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1305	73/9376	1.4763029444182	GADD45B/BRAF/PIK3CD/MAPK1/PIK3R1/RB1/TP53/PIK3CA/RAF1/MAP2K1/IGF1R/PTEN/AKT2/POLK/BAK1	1.64270812879356
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	47/1305	275/9376	1.22792615813305	FYN/RAC2/MT-CO1/CYBA/MT-CO2/MT-CO3/MT-ATP6/PRKACB/MT-CYB/MT-ND4/TUBA1A/MT-ND1/HSPA8/MT-ND2/CREB1/PIK3CD/MT-ND5/PPP3CA/PPP3CC/ITPR1/EIF2AK3/MAPK1/TUBA4A/MAPK14/PIK3R1/GSK3B/ITPR2/EGR1/MAPK8/SDHA/PIK3CA/PSMD12/DDIT3/CYCS/C1QB/STIP1/MT-ND6/NCAM1/HSPA5/C1QA/ATF2/TUBB2A/HSPA6/CASP9/C1QC/MT-ND4L/NOTCH1	1.54256395964014
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/1305	69/9376	1.45776000888445	PDE3B/PRKACB/PTGER4/CREB1/PPP3CA/PPP3CC/ITPR1/ORAI1/PLCB1/ITPR2/GNAI3/GNAI2/ADRB2/PLCB2	1.53456312371051
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	19/1305	101/9376	1.35157239861917	PRKACB/PRKCB/PRKCA/LEF1/CAMK2D/CREB1/CREBBP/TCF7/MAPK1/PLCB1/GSK3B/EP300/GNAI3/GNAI2/RAF1/ADCY7/MAP2K1/CTNNB1/PLCB2	1.42838644470089
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	63/1305	388/9376	1.16658371845005	NFKB1/MT-CO1/MT-CO2/MT-CO3/MT-ATP6/MT-CYB/MT-ND4/TUBA1A/BRAF/MT-ND1/MT-ND2/ADAM10/CASP8/ERN1/PIK3CD/MT-ND5/PPP3CA/PPP3CC/ITPR1/RB1CC1/EIF2AK3/MAPK1/CSNK1A1/TUBA4A/PIK3R1/ATG14/AMBRA1/PLCB1/GSK3B/ITPR2/MAPK8/ADAM17/SDHA/XBP1/PIK3CA/IKBKB/PSMD12/NRBF2/ATP2A2/DDIT3/RAF1/ATP2A3/CYCS/ATF6/MAP2K1/TPTEP2-CSNK1E/CTNNB1/PSEN1/SLC39A10/PIK3C3/MT-ND6/BECN1/FAS/TUBB2A/FRAT2/IRS2/CASP9/APC/AKT2/MAP3K5/PLCB2/MT-ND4L/CHUK	1.34754756432495
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/1305	41/9376	1.5771236333053	BRAF/MYC/RPS6KA5/MAPK1/RB1/TP53/RASSF1/RAF1/MAP2K1	1.48912394360905
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1305	71/9376	1.41669634666235	JUN/NFKB1/NFKBIA/ADAM10/CSK/MAPK14/MAPK8/ADAM17/MAP3K14/IKBKB/PLCG2/MAP2K4/LYN/CHUK	1.41715677989638
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	53/1305	323/9376	1.17890941010403	ATM/NFKB1/GLS/STAT3/PRKCB/SOCS1/CD44/CCND2/ZEB1/MCL1/ROCK1/PRKCA/MYC/CDKN1B/CREBBP/DDIT4/BCL2/PIK3CD/ZEB2/RPS6KA5/SIRT1/MAPK1/EZH2/FOXP1/SOS1/SOS2/PIK3R1/TP53/PIM1/EP300/RASSF1/SOX4/ITGA5/PIK3CA/IKBKB/PLCG2/VIM/MDM4/RAF1/ABCB1/MAP2K1/HDAC4/BCL2L11/PTEN/IRS2/APC/HDAC1/GRB2/DNMT3A/RPTOR/CDC25B/BAK1/NOTCH1	1.31572584332218
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/1305	53/9376	1.49115882310417	PRKACB/PRKCB/PRKCA/ATP2B1/ATP1A1/PLCB1/AP2B1/ATP2B4/RAB11A/ATP1B3/PLCB2	1.44181408274431
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	19/1305	102/9376	1.33832168882879	PRKCB/PRKCA/RAP1B/ATP2B1/ITPR1/CD38/RAP1A/ATP1A1/PLCB1/ITPR2/SLC12A2/ATP2A2/ATP2A3/ADCY7/ATP2B4/SLC4A4/RAB11A/ATP1B3/PLCB2	1.38141319672609
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	12/1305	59/9376	1.46128969413598	PDE3B/PRKACB/PIK3CD/PIK3R1/GNAI3/PIK3CA/GNAI2/ADCY7/ADRB2/CGA/IRS2/AKT2	1.42918658289528
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/1305	78/9376	1.38166814028883	ELMO1/SEPTIN6/SEPTIN9/PIK3CD/SEPTIN1/CBL/PIK3R1/ACTR2/ITGA5/PIK3CA/ARPC4/CTNNB1/HCLS1/VCL/ILK	1.36102361156112
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1305	14/9376	2.0527640941434	ST3GAL1/B4GALT1/CHST2/B3GNT2	1.58503181615789
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/1305	91/9376	1.34219190770915	GNG2/PDE3B/PDE7A/PRKACB/PDE4D/PRKCB/PRKCA/ARRB2/GRK2/GRK5/PDE4B/GRK6/GNAI3/PDE7B/GNAI2/ADCY7/GNB5	1.31894503527828
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	29/1305	170/9376	1.22562091503268	JUN/MSN/RAB8B/PRKACB/TUBA1A/ROCK1/HSPA4/ARHGEF18/WHAMM/RAPGEF2/TUBA4A/RAP1A/RUNX1/ACTR2/MAPK8/MYH9/MAP3K1/WAS/ARPC4/PPP2R2A/PRKAG2/DLG1/HCLS1/PPP2R2D/ROCK2/PPP2R2B/PPP2R1A/MAP3K5/PRKAA1	1.19370098441614
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/1305	50/9376	1.43693486590038	GYPC/ITGB2/TGFB1/ITGAL/IFNG/KLRB1/ICAM1/KLRC4-KLRK1/CD81/PECAM1	1.24560751080328
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/1305	44/9376	1.46959247648903	MGAT4A/B4GALT1/MAN2A1/ALG13/MAGT1/ALG3/MAN1A1/HEXA/MAN1C1	1.25541503026726
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/1305	44/9376	1.46959247648903	PRKACB/ARHGDIB/CREB1/DYNC1H1/VAMP2/DCTN4/AQP3/RAB11A/DYNC1LI2	1.25541503026726
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	39/1305	238/9376	1.17732058340578	JUN/RPS4Y1/NFKB1/JAK1/NFKBIA/STAT3/PRKCB/RPS10/PRKCA/PIK3CD/STAT1/MAPK1/TAB2/MAPK14/PIK3R1/RPL36A/ISG15/MAPK8/ADAM17/FOS/IRAK4/PIK3CA/RPL17/IKBKB/PLCG2/IFNAR1/ADAR/CGAS/C1QB/MAP3K7/TYK2/MX2/RPL10/C1QA/IL6R/RSL24D1/C1QC/TRAF3/CHUK	1.11416438942672
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1305	21/9376	1.7106367451195	CHST11/CHST12/CSGALNACT2/UST/CSGALNACT1	1.31087907712835
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/1305	63/9376	1.3685093960956	CCNH/RPA2/POLR2C/RFC1/POLR2M/RPA1/MNAT1/ERCC3/CUL4A/POLR2A/POLD2/ERCC1	1.18005231013372
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	23/1305	134/9376	1.23319036998913	PRKCH/PRKACB/PRKCB/ARHGEF1/BRAF/PRKCQ/ROCK1/PRKCA/PPP1R12A/ITPR1/MAPK1/PLCB1/ITPR2/MYH9/RAF1/ADCY7/MAP2K1/CALCRL/PPP1CB/ROCK2/PLA2G6/GNA13/PLCB2	1.0932191960973
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/1305	33/9376	1.5240218274701	VTI1A/VAMP2/STX5/STX16/VAMP5/STX8/VAMP7	1.21252413880112
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/1305	70/9376	1.33429666119321	FYN/RAC2/ITGB2/ITGAL/CASP8/PRF1/EIF4G3/ICAM1/CD55/CYCS/CD28/SNTB1/CASP9	1.1288253540795
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	49/1305	308/9376	1.14301637060258	MT-CO1/MT-CO2/MT-CO3/MT-ATP6/MT-CYB/MT-ND4/TUBA1A/SOD2/MT-ND1/MT-ND2/CREB1/CREBBP/CASP8/ERN1/MT-ND5/ITPR1/RB1CC1/TUBA4A/DCTN4/ATG14/AMBRA1/PLCB1/AP2B1/TP53/EP300/MAPK8/SDHA/TBPL1/PSMD12/NRBF2/GPX7/RCOR1/CYCS/POLR2C/REST/PIK3C3/HTT/TAF4B/MT-ND6/BECN1/TUBB2A/CASP9/ACTR1B/HDAC1/NRF1/POLR2A/MAP3K5/PLCB2/MT-ND4L	1.02620133534017
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/1305	71/9376	1.31550375047218	GLS/MYC/PIK3CD/MAPK1/PIK3R1/TP53/PIK3CA/RAF1/HIF1A/MAP2K1/SLC7A5/PTEN/AKT2	1.07300743729987
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	17/1305	97/9376	1.25916972785085	GNG2/PRKACB/PRKCB/PRKCA/CAMK2D/CREB1/PER1/ITPR1/RPS6KA5/MAPK1/PLCB1/FOS/GNAI3/GNAI2/ADCY7/GNB5/PLCB2	1.03168418422519
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	40/1305	250/9376	1.14954789272031	LAPTM5/NCOA7/CTSW/IGF2R/GNPTAB/VPS13C/VPS13A/LITAF/AP2B1/CTSC/AP1S2/WDR7/SPG11/RAB7A/AP3B1/GGA1/OSBPL5/KXD1/AP3M2/GLA/ENTPD4/VPS41/DMXL1/TELO2/NPC1/CTSS/CTSD/SLC36A4/ARSB/HEXA/SUMF1/GPR155/GGA2/VAMP7/RPTOR/SLC15A4/VPS39/AP3D1/TMEM175/BLOC1S1	0.963689862062994
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1305	47/9376	1.37578870139398	SOCS1/PIK3CD/MAPK1/PIK3R1/MAPK8/PIK3CA/IKBKB/SOCS3/IRS2	1.0384900052592
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	30/1305	184/9376	1.17141429285357	FYN/RAC2/CXCR4/SSH2/NFATC3/ROCK1/PRKCA/NFATC2/CAMK2D/PIK3CD/PPP3CA/PPP3CC/SEMA4D/RGS3/MAPK1/ABLIM1/PIK3R1/GSK3B/GNAI3/RYK/EPHA4/NCK2/PIK3CA/PLCG2/GNAI2/RAF1/NCK1/LRIG2/ROCK2/ILK	0.944230784375166
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/1305	23/9376	1.56188572380476	MSH3/RPA2/RFC1/RPA1/POLD2	1.08483495172192
Organismal Systems	Digestive system	hsa04970	Salivary secretion	16/1305	93/9376	1.23607300292506	PRKACB/PRKCB/PRKCA/ATP2B1/ITPR1/VAMP2/CD38/ATP1A1/PLCB1/ITPR2/SLC12A2/ADCY7/ATP2B4/ADRB2/ATP1B3/PLCB2	0.919964023265241
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1305	48/9376	1.34712643678161	HMGCS1/HIBCH/DBT/ACAA2/OXCT1/IVD/PCCB/ACAA1/ACADM	0.96948537211984
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1305	48/9376	1.34712643678161	PRKCB/PIK3CD/ATP1A1/PIK3R1/PLCB1/PIK3CA/AKT2/ATP1B3/PLCB2	0.96948537211984
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1305	42/9376	1.3685093960956	TP53/PCBP2/TFRC/SAT2/LPCAT3/GCLM/ATG7/ACSL3	0.962424196378216
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	7/1305	36/9376	1.39702000851426	RPA2/RNASEH2C/RFC1/RNASEH2B/POLA1/RPA1/POLD2	0.959660074744257
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1305	55/9376	1.3063044235458	SAMD8/CERS6/CERK/UGCG/SGMS1/GLA/DEGS1/HEXA/CERS4/SPTLC2	0.916074047994621
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	37/1305	235/9376	1.13120404336839	MT-CO1/MT-CO2/MT-CO3/MT-ATP6/ARID1B/PRKACB/MT-CYB/MT-ND4/RPS6KA3/MT-ND1/MT-ND2/CREB1/MT-ND5/SMARCC1/SOS1/SOS2/KDM3A/MAPK14/ARID1A/SMARCA2/SMARCC2/SDHA/KDM3B/ADCY7/PRKAG2/MT-ND6/ATF2/COA1/GRB2/MAP2K3/RPS6KB1/COX11/RPTOR/MAP3K5/PRKAA1/MT-ND4L/ACSL3	0.819052077295072
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1305	37/9376	1.35926271098685	PRKCB/PRKCA/IFNG/PLCB1/ICAM1/FAS/PLCB2	0.880420279449028
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1305	76/9376	1.22895745109901	PRKACB/PRKCB/PRKCA/CAMK2D/ITPR1/ATP1A1/PLCB1/ITPR2/GNAI3/GNAI2/ADCY7/ATP1B3/PLCB2	0.805837222115728
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/1305	50/9376	1.29324137931034	ODC1/AMD1/ARG2/SAT2/P4HA1/OAT/PYCR2/GOT2/LAP3	0.835968225594881
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	19/1305	116/9376	1.17680010569428	GLS/GNG2/PRKACB/PRKCB/SLC38A2/PRKCA/SLC38A1/PPP3CA/PPP3CC/ITPR1/GRK2/MAPK1/PLCB1/ITPR2/GNAI3/GNAI2/ADCY7/GNB5/PLCB2	0.770430100043856
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1305	103/9376	1.18582003496634	NFKB1/ITGB2/PRKACB/PRKCB/PRKCA/TGFB1/PIK3CD/SERPINB9/IFNG/PIK3R1/PLCB1/ARG2/RAB7A/PIK3CA/VCL/ITGAM/PLCB2	0.762479620366758
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	17/1305	104/9376	1.17441791924551	GPCPD1/ETNK1/DGKZ/SAMD8/LCLAT1/LPIN2/AGPAT4/DGKD/SGMS1/LPCAT3/DGKA/LPIN1/DGKE/PLA2G6/CEPT1/DGKQ/TAFAZZIN	0.71919768324694
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	41/1305	268/9376	1.09914793846858	MT-CO1/MT-CO2/MT-CO3/MT-ATP6/PRKACB/MT-CYB/MT-ND4/TUBA1A/MT-ND1/MT-ND2/CAMK2D/ERN1/MT-ND5/DUSP1/ITPR1/NFE2L2/EIF2AK3/UBE2G1/TUBA4A/ITPR2/TP53/MAPK8/SDHA/GNAI3/XBP1/UBE2G2/PSMD12/GNAI2/DDIT3/CYCS/ATF6/SLC39A10/MT-ND6/HSPA5/TRAP1/TUBB2A/CASP9/HTRA2/MAP3K5/UBC/MT-ND4L	0.66216587432884
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	11/1305	65/9376	1.21586796345417	DGKZ/LCLAT1/LPIN2/AGPAT4/DGKD/GLA/DGKA/LPIN1/DGKE/AGK/DGKQ	0.702221188766615
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1305	65/9376	1.21586796345417	NR4A1/PRKACB/CREB1/ITPR1/ORAI1/PLCB1/ITPR2/LDLR/ADCY7/ATF2/PLCB2	0.702221188766615
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1305	52/9376	1.24350132625995	MYLIP/OSBPL5/LDLR/VAPB/NPC1/STARD3NL/PLTP/SOAT1/STARD3	0.707993206995791
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	20/1305	128/9376	1.12260536398467	PDE3B/PDE7A/PDE4D/ADA/DCK/PDE4B/NT5C2/FHIT/PDE7B/ADCY7/ADA2/ENTPD4/PRPS1/GART/NUDT5/HPRT1/IMPDH2/NUDT9/AK3/AMPD2	0.561587930720527
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1305	54/9376	1.19744572158365	REV3L/ATR/WDR48/RPA2/TELO2/RPA1/REV1/POLK/ERCC1	0.585082729157122
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1305	41/9376	1.22665171479301	ATM/UIMC1/RAD51B/RPA2/BABAM2/RPA1/POLD2	0.58481835759406
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1305	15/9376	1.43693486590038	ST3GAL1/ST3GAL5/HEXA	0.680970704047718
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	21/1305	138/9376	1.09332000666334	PPP2R5C/PRKACB/RPS6KA3/CAMK2D/PPP3CA/PPP3CC/ITPR1/MAPK1/MAPK14/ITPR2/BTRC/PPP2R5A/ADCY7/MAP2K1/ANAPC1/PPP1CB/IGF1R/CDC27/PPP2R5E/CPEB2/PPP2R1A	0.444071136204251
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1305	83/9376	1.1253104371509	NFKB1/IFI16/NFKBIA/CASP8/SAMHD1/POLR3GL/IKBKB/ADAR/CGAS/PYCARD/G3BP1/RIPK1/CHUK	0.461079212821401
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1305	49/9376	1.17300805379623	JUN/NFKB1/PRKACB/FOSB/CREB1/GNAI3/GNAI2/ATF2	0.488225650466594
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	29/1305	195/9376	1.06849002849003	NFKB1/RAC2/ITGB2/CYBA/PRKCB/PRKCA/ITGAL/PIK3CD/MAPK1/MAPK14/PIK3R1/PLCB1/FCGR3A/SELPLG/HDAC7/PIK3CA/PLCG2/RAF1/HDAC3/MAP3K7/MAP2K1/H3C12/CLCN3/HDAC4/ITGAM/AKT2/HDAC1/ATG7/PLCB2	0.388621549666509
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1305	16/9376	1.34712643678161	ST3GAL1/GLA/HEXA	0.558775013450724
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1305	23/9376	1.24950857904381	GLS/ATP1A1/SLC4A4/ATP1B3	0.481727183720452
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/1305	30/9376	1.19744572158365	NFKB1/IKBKB/GART/SLC19A1/CHUK	0.435534624797209
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/1305	31/9376	1.15881844024224	IMMP2L/HSPA5/SEC61A1/SEC63/SPCS3	0.356138840931331
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/1305	45/9376	1.11761600681141	IFNG/KLRD1/PRF1/KLRC1/GZMB/CD28/FAS	0.318006365363967
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1305	32/9376	1.12260536398467	PIK3C3/BECN1/ATG4B/RPTOR/ATG7	0.279347806567884
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1305	18/9376	1.19744572158365	LMBRD1/THAP11/ZNF143	0.337147295337778
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	23/1305	160/9376	1.0327969348659	PTPRC/ITGB2/ITGA4/GLG1/ITGAL/SELL/CD2/ICAM3/ICAM2/ICAM1/SELPLG/JAML/CD58/CD226/CD28/ICOS/NCAM1/PECAM1/CD8B/SPN/ITGAM/CD8A/CD6	0.168247738747453
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1305	89/9376	1.04944681217444	GLS/GNG2/PRKACB/PRKCB/SLC38A2/PRKCA/SLC38A1/GPHN/PLCL1/GNAI3/GNAI2/ADCY7/GNB5	0.188461567464612
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1305	19/9376	1.13442226255293	OGDH/DBT/LIAS	0.235834266079156
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/1305	149/9376	1.01260510684255	GNG2/PRKACB/PRKCB/MT-ND4/PRKCA/MT-ND1/MT-ND2/MT-ND5/ITPR1/MAPK1/MAPK14/PLCB1/ITPR2/MAPK8/GNAI3/GNAI2/ADCY7/GNB5/MT-ND6/PLCB2/MT-ND4L	0.0623643823431725
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1305	12/9376	1.19744572158365	NCAM1/NPC1	0.275191406824162
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/1305	63/9376	1.0263820470717	GADD45B/LEF1/TCF7/GSK3B/TP53/CTNNB1/APC/POLK/BAK1	0.0844814160042261
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/1305	34/9376	1.05656975433852	POLR3GL/POLR2C/CRCP/POLR2M/POLR2A	0.132871255965506
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/1305	49/9376	1.0263820470717	OGT/ST6GAL1/B4GALT1/MFNG/GALNT10/LFNG/B3GLCT	0.0744496675709252
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/1305	20/9376	1.07770114942529	LBR/CYP2R1/SOAT1	0.139869993587197
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	16/1305	115/9376	0.999606863235049	GNG2/PRKACB/PRKCB/BRAF/PRKCA/DUSP1/ITPR1/MAPK1/PLCB1/ITPR2/GNAI3/GNAI2/RAF1/MAP2K1/GNB5/PLCB2	-0.00170565368973994
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	12/1305	86/9376	1.0025126971398	PRKACB/PRKCB/PRKCA/CAMK2D/CREB1/VAMP2/ATP1A1/PLCB1/ADCY7/ATF2/ATP1B3/PLCB2	0.00941258117038284
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1305	44/9376	0.979728317659352	POLG2/POLB/PARP4/RFC1/POLD2/PNKP	-0.0541945963221737
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/1305	44/9376	0.979728317659352	IFNG/PRF1/HSPD1/GZMB/CD28/FAS	-0.0541945963221737
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1305	30/9376	0.957956577266922	SUCLG2/SDHA/OGDH/ACLY	-0.0927412668067536
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1305	38/9376	0.945351885460778	CD38/SIRT1/NT5C2/NAMPT/SIRT7	-0.135727317702568
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1305	76/9376	0.945351885460778	HMGCS1/PLIN2/PPARD/SLC27A4/ILK/PLTP/ACAA1/ACADM/UBC/ACSL3	-0.19233916434152
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1305	23/9376	0.937131434282859	GLS/ARG2/GOT2	-0.121380584281011
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1305	23/9376	0.937131434282859	IDI1/HMGCS1/PDSS2	-0.121380584281011
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/1305	39/9376	0.921112093525887	IFNG/PRF1/GZMB/CD28/FAS	-0.198502634669811
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/1305	85/9376	0.929781383817895	ADA/DCK/NT5C2/ADA2/ENTPD4/NT5C3A/UPP1/HPRT1/IMPDH2/AK3/AMPD2	-0.261491586297027
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/1305	32/9376	0.898084291187739	SUCLG2/HIBCH/DBT/PCCB	-0.232207864209553
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1305	48/9376	0.898084291187739	CD81/TGOLN2/IST1/LDLR/CHMP1B/PDCD6IP	-0.284639193138938
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1305	17/9376	0.845255803470814	MYH9/TFRC	-0.256774166293999
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/1305	50/9376	0.86216091954023	ITGA4/CXCR4/TGFB1/MAP3K14/CD28/ICOS	-0.392949630030331
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1305	26/9376	0.829000884173298	LMBRD1/BTD/SLC19A1	-0.351076656563885
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/1305	59/9376	0.85241898824599	ODC1/GSTA3/GPX7/GSTT1/GCLM/LAP3/GSR	-0.457241522128531
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/1305	43/9376	0.835427247616502	ACAA2/ACAA1/GCDH/ACADM/ACSL3	-0.434919367511525
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1305	18/9376	0.798297147722435	CBR4/ACSL3	-0.344416534133332
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/1305	100/9376	0.86216091954023	IL2RG/CXCR4/CCR7/TNFRSF1B/TNFSF10/IL2RB/IL10RA/IL18RAP/XCL2/IL6R/CXCR3/TNFSF14	-0.557210405062759
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1305	19/9376	0.756281508368623	ARSB/HEXA	-0.427586699644866
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/1305	54/9376	0.798297147722435	MAT2A/AMD1/AHCYL2/GCLM/DNMT3A/GOT2	-0.597697708224762
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1305	29/9376	0.74324217201744	RASSF1/TPTEP2-CSNK1E/RASSF4	-0.55681867321112
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1305	39/9376	0.736889674820709	MAT2A/AHCYL2/GART/MTHFD2L	-0.662054490875079
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/1305	57/9376	0.756281508368623	ELOVL5/ACAA2/CBR4/ACAA1/ACADM/ACSL3	-0.742110324986555
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/1305	155/9376	0.834349276974416	ITGB2/CORO1A/CYBA/TUBA1A/DYNC1H1/TUBA4A/FCGR3A/RAB7A/ITGA5/TFRC/PIK3C3/CTSS/TUBB2A/ITGAM/SEC61A1/DYNC1LI2/STX12/MSR1	-0.836175414758671
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1305	12/9376	0.598722860791826	COQ7	-0.559282923830218
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/1305	32/9376	0.673563218390805	B4GALT1/GALM/GLA	-0.743763534986991
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/1305	59/9376	0.730644847067991	DPYD/DCK/NT5C2/ENTPD4/NT5C3A/UPP1	-0.834527143133292
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1305	23/9376	0.624754289521906	LNPEP/PREP	-0.724488352282475
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/1305	51/9376	0.704379836225678	PRKACB/PRKCA/SLC12A2/PLCG2/SEC61A1	-0.851181040532058
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1305	33/9376	0.653152211772901	OGDH/DBT/GOT2	-0.802564499546785
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1305	13/9376	0.552667256115532	POLM	-0.648966193406473
Human Diseases	Substance dependence	hsa05034	Alcoholism	22/1305	191/9376	0.82755411125153	GNG2/PRKACB/FOSB/BRAF/CAMK4/CREB1/MAPK1/SOS1/SOS2/GNAI3/HDAC7/GNAI2/RAF1/HDAC3/MAP2K1/GNB5/H3C12/PPP1CB/HDAC4/ATF2/HDAC1/GRB2	-0.96818236650329
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1305	24/9376	0.598722860791826	EXT1/HS2ST1	-0.79145278346699
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/1305	52/9376	0.690834070144415	PRKACB/LDLR/ADCY7/IGF1R/CGA	-0.898916574846992
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/1305	87/9376	0.74324217201744	MT-CO1/MT-CO2/MT-CO3/MT-CYB/ATP1A1/ATP2A2/ATP2A3/TPM3/ATP1B3	-0.967444496546128
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/1305	54/9376	0.665247623102029	PRF1/GZMB/CD28/CGA/FAS	-0.991957854018723
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1305	26/9376	0.552667256115532	PLA2G6/ACAA1	-0.918414597264157
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	29/1305	254/9376	0.820297462817148	CXCR4/STIM2/NFATC3/PRKACB/PRKCB/PRKCA/ATP2B1/NFATC2/CAMK4/CAMK2D/PPP3CA/PPP3CC/ITPR1/CD38/ORAI1/STIM1/PLCB1/CAMK1D/ITPKB/ITPR2/PLCG2/ATP2A2/ATP2A3/PTK2B/ADCY7/ATP2B4/ADRB2/PLCB2/NFATC1	-1.16749022648709
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1305	46/9376	0.624754289521906	IFNG/PSME4/PSMF1/PSMD12	-1.02584335773615
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/1305	37/9376	0.582541161851507	NANS/GALK2/GPI	-1.02303750347922
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1305	27/9376	0.532198098481623	HMGCS1/OXCT1	-0.978787705053169
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/1305	27/9376	0.532198098481623	ELOVL5/ACAA1	-0.978787705053169
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1305	16/9376	0.44904214559387	GOT2	-0.886885727750707
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/1305	38/9376	0.567211131276467	GALK2/GPI/HEXA	-1.07490025554706
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/1305	28/9376	0.513191023535851	ELOVL5/ACAA2	-1.03730258924582
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1305	28/9376	0.513191023535851	B4GALT1/B3GNT2	-1.03730258924582
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1305	28/9376	0.513191023535851	GCH1/GPHN	-1.03730258924582
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1305	17/9376	0.422627901735407	MARS1	-0.9580600920652
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1305	17/9376	0.422627901735407	CA5B	-0.9580600920652
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/1305	86/9376	0.668341798093201	ITGA4/LEF1/TCF7/ITGA5/ATP2A2/ATP2A3/CTNNB1/SNTB1	-1.24239395859571
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	14/1305	138/9376	0.728880004442223	MT-CO1/MT-CO2/MT-CO3/MT-ATP6/MT-CYB/MT-ND4/MT-ND1/MT-ND2/MT-ND5/SDHA/CYCS/MT-ND6/COX11/MT-ND4L	-1.29014740546881
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1305	18/9376	0.399148573861218	HEXA	-1.02598036360444
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1305	51/9376	0.563503868980542	PAFAH1B1/AGPS/PLA2G6/CEPT1	-1.25680611987277
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/1305	61/9376	0.588907731926386	ATP2B1/ATP1A1/TRPM7/ATP2B4/ATP1B3	-1.29520948694867
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/1305	116/9376	0.68130532434932	SUCLG2/HIBCH/ME2/SDHA/OGDH/ADPGK/PRPS1/PGK1/GPI/PCCB/GOT2	-1.38875466098176
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1305	31/9376	0.463527376096898	PRPS1/GPI	-1.20300097505567
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/1305	31/9376	0.463527376096898	DPYD/HIBCH	-1.20300097505567
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	9/1305	99/9376	0.653152211772901	ITGB2/ITGAL/FCGR3A/ICAM1/SELPLG/C1QB/C1QA/ITGAM/C1QC	-1.39501850576011
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/1305	99/9376	0.653152211772901	ITGA4/TGFB1/ITGA5/ATP2A2/ATP2A3/PRKAG2/SNTB1/TPM3/PRKAA1	-1.39501850576011
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/1305	20/9376	0.359233716475096	NANS	-1.15344466112046
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1305	21/9376	0.342127349023901	DPYD	-1.21354756773027
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/1305	75/9376	0.574773946360153	MAT2A/ARG2/PRPS1/PGK1/PYCR2/GOT2	-1.48666424247178
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1305	45/9376	0.478978288633461	ABCG1/ABCB1/ABCB7	-1.40872169698006
NA	NA	hsa04519	Cadherin signaling	45/1305	404/9376	0.800273130761352	NFKB1/RAC2/NFKBIA/TAOK3/EVL/ERBIN/TMC8/ROCK1/LEF1/ADAM10/CREBBP/TMC6/TCF7/MAPK1/CSNK1A1/CYFIP2/MAPK14/MYO1F/GSK3B/ACTR2/EP300/RERE/MAPK8/SHOC2/TAOK1/RYK/IKBKB/VIM/ARPC4/RAF1/PTK2B/NCKAP1L/MAP2K1/MYO1G/CTNNB1/PSEN1/VAV1/PPP1CB/RRAS2/IGF1R/VCL/ROCK2/APC/MAP2K3/CHUK	-1.65009810249094
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	18/1305	183/9376	0.706689278311664	NOP58/NXF1/XRN1/NOP56/XRN2/RBM28/IMP4/BMS1/NXT1/RIOK2/RIOK1/GNL3L/MPHOSPH10/EMG1/LSG1/DKC1/MDN1/WDR43	-1.61120972175166
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1305	22/9376	0.326576105886451	CARNMT1	-1.27153523655202
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/1305	95/9376	0.605025206694898	JUN/ITGB2/TGFB1/ITGAL/IFNG/ICAM1/FOS/CD28	-1.55582597245082
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/1305	105/9376	0.615829228243021	ITGA4/PRKACB/TGFB1/ITGA5/ATP2A2/ATP2A3/ADCY7/SNTB1/TPM3	-1.59177947130237
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1305	23/9376	0.312377144760953	B4GALT1	-1.32759612028394
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1305	36/9376	0.399148573861218	PGM2L1/GPI	-1.45235280880768
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1305	36/9376	0.399148573861218	ST3GAL1/GALNT10	-1.45235280880768
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1305	37/9376	0.388360774567671	GLS/GOT2	-1.49890194921128
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/1305	90/9376	0.558808003405705	PRKACB/ATP1A1/LDLR/ADCY7/ABCB1/SLC4A4/ATP1B3	-1.69107068484015
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/1305	82/9376	0.525707877768433	DPYD/GSTA3/GSTT1/UPP1/HPRT1/IMPDH2	-1.73451765127856
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/1305	83/9376	0.519374047915801	SOD2/NUDT19/AGPS/ACAA1/HACL1/ACSL3	-1.76846111694315
Cellular Processes	Cell motility	hsa04814	Motor proteins	18/1305	194/9376	0.666619267685745	TUBA1A/DYNC1H1/KIF13B/TUBA4A/DCTN4/MYO1F/CAPZA1/MYH9/HOOK3/BICDL1/MYO1G/KIF2A/TUBB2A/TPM3/ACTR1B/KIF21B/DYNC1LI2/MYO9A	-1.88668734913931
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/1305	43/9376	0.334170899046601	SLC27A4/GOT2	-1.75959851958128
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/1305	88/9376	0.489864158829676	ITGB2/CD55/C1QB/C1QA/ITGAM/C1QC	-1.9332734662879
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/1305	67/9376	0.428935780865786	GALM/ADPGK/PGK1/GPI	-1.88624480312136
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/1305	30/9376	0.23948914431673	PIGL	-1.67756894161864
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1305	30/9376	0.23948914431673	PLA2G6	-1.67756894161864
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/1305	31/9376	0.231763688048449	PCCB	-1.72271424705134
NA	NA	hsa04981	Folate transport and metabolism	1/1305	31/9376	0.231763688048449	SLC19A1	-1.72271424705134
Human Diseases	Immune disease	hsa05310	Asthma	1/1305	32/9376	0.224521072796935	FCER1G	-1.76687487654187
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/1305	233/9376	0.647545755019486	ITGA4/SUN2/SPTAN1/SYNE1/FMNL1/DIAPH1/ATP1A1/CAPZA1/SPTBN1/MYH9/SYNE2/ITGA5/LBR/TLN1/VIM/SNTB1/VCL/PDLIM2/TPM3/ATP1B3/AMPD2	-2.19060243770141
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/1305	47/9376	0.305730822531996	ME2/ACYP2	-1.91860904568322
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/1305	298/9376	0.675070071228368	IL2RG/IL16/CXCR4/IL32/IL7R/TGFBR2/CD27/TGFB1/IFNG/CCR7/TNFRSF1B/TNFRSF25/TNFSF10/IL2RB/IL10RA/IL4R/IFNAR1/IL12RB2/IL18RAP/XCL2/IL17RA/IL21R/FAS/IL6R/CXCR3/TNFSF14/IL12RB1/TNFRSF18	-2.29208109205
NA	NA	hsa04081	Hormone signaling	19/1305	219/9376	0.623327909865463	GNG2/PRKACB/STAT3/STAT5B/PIK3CD/PIK3R1/PLCB1/SLC16A10/GNAI3/PIK3CA/GNAI2/ADCY7/ADRB2/GNB5/IGF1R/CGA/IRS2/GNA13/PLCB2	-2.26796377049565
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/1305	35/9376	0.20527640941434	PFKFB3	-1.89400299460164
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1305	37/9376	0.194180387283836	GOT2	-1.97476639494335
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1305	68/9376	0.316970926301555	DHRS4L2/RDH11/PNPLA4	-2.27296464027149
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/1305	42/9376	0.17106367451195	GCDH	-2.16490647283136
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/1305	154/9376	0.466537294123501	GCH1/MAT2A/GPHN/RDH11/COQ7/EPRS1/GCLM/LIAS/AK3/MTHFD2L	-2.68397882608652
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/1305	46/9376	0.156188572380476	EPRS1	-2.30680411270386
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/1305	89/9376	0.322906711438288	ITGA4/CD44/SPP1/ITGA5	-2.58067318944533
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/1305	63/9376	0.228084899349267	PLA2G6/LTA4H	-2.47185067029792
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/1305	103/9376	0.34877059851951	SLC38A2/ATP1A1/SLC16A10/SLC36A4/ATP1B3	-2.67220457095745
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/1305	79/9376	0.272835734031718	VAMP2/AP2B1/NAPA	-2.60976786589046
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/1305	70/9376	0.20527640941434	GSTA3/GSTT1	-2.68355698000732
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1305	86/9376	0.250628174284951	PRKACB/PLCB1/PLCB2	-2.80715213330332
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/1305	73/9376	0.196840392589094	GSTA3/GSTT1	-2.7699950866861
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/1305	143/9376	0.351697344800793	IFNG/FCGR3A/C1QB/CD28/H3C12/C1QA/C1QC	-3.14124363529186
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/1305	79/9376	0.181890489354479	GSTA3/GSTT1	-2.93616726176583
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/1305	66/9376	0.10885870196215	HSD17B11	-2.92126475005437
NA	NA	hsa04082	Neuroactive ligand signaling	11/1305	199/9376	0.397142802133272	GNG2/PRKACB/PRKCB/PRKCA/PLCB1/GNAI3/GNAI2/ADCY7/ADRB2/GNB5/PLCB2	-3.4563510295321
Genetic Information Processing	Translation	hsa03010	Ribosome	13/1305	222/9376	0.42072417244831	RPS4Y1/RPS10/RPL36A/MRPS9/RPL17/MRPL18/MRPS35/MRPS28/RPL10/MRPS25/DAP3/RSL24D1/MRPS30	-3.51223575599329
NA	NA	hsa04382	Cornified envelope formation	12/1305	217/9376	0.397309179511627	PPP2R5C/S100A9/UGCG/PPP2R5A/PPP2R2A/PPP2R2D/SLC27A4/PPP2R5E/PPP2R2B/PPP2R3C/PPP2R1A/SPTLC2	-3.61183277510597
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/1305	370/9376	0.213598426012219	S1PR4/PTGER4/LPAR6/GZMA/P2RY8/NR3C1/ADRB2/CALCRL/PTGDR/CGA/P2RY10	-6.20592446324278
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1305	449/9376	0.0960090110846581	PRKACB/CAMK2D/ARRB2/GRK2/NCALD/RGS2	-7.89335662592836