category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	34/666	82/9376	5.83725188603237	HLA-E/HSP90AA1/HLA-A/HLA-C/HLA-B/PSME1/HLA-F/HSPA1A/HSP90AB1/TAPBP/PSME2/CTSB/HLA-DRA/CANX/HSPA8/HSPA1B/HLA-DRB1/IFI30/TAP1/B2M/HLA-G/LGMN/TNF/HSPA4/TAP2/CTSL/HLA-DPA1/HSPA2/HLA-DMA/HLA-DPB1/HLA-DQA1/HSPA6/HLA-DQB1/HLA-DMB	12.1651640543045
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	50/666	224/9376	3.14242814242814	JUN/HLA-E/HLA-A/HLA-C/HLA-B/ZFP36/HLA-F/EGR1/HLA-DRA/FOS/GPS2/CANX/NFKBIA/HLA-DRB1/LTA/B2M/CCND2/HLA-G/ATF4/MAD1L1/MYC/CDKN1A/TNF/PRKACA/NFKB2/HLA-DPA1/ATF6B/HRAS/HLA-DMA/HLA-DPB1/MSX2/HLA-DQA1/PTEN/CCNE1/ICAM1/EGR2/PPP3R1/PIK3R3/PTTG1/CRTC2/TNFRSF13C/SLC2A1/NRP1/AKT3/HLA-DQB1/SPI1/HLA-DMB/RELA/KAT2A/E2F1	8.97399747951
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	44/666	205/9376	3.02163627041676	PLCG2/JUN/HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/TAPBP/HLA-DRA/NFKBIA/PSMC4/HLA-DRB1/NFKBIB/GADD45B/TAP1/B2M/CCND2/HLA-G/MYC/CDKN1A/TNF/NFKB2/TAP2/HLA-DPA1/IRF9/HLA-DMA/IRF7/HLA-DPB1/HLA-DQA1/GADD45G/CCNE1/NFKBIE/ICAM1/PIK3R3/AKT3/HLA-DQB1/HES1/MAP2K3/HLA-DMB/RELA/BTK/RUNX3/FADD/E2F1	8.09254792076608
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	37/666	155/9376	3.36057347670251	HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/ATP6V0C/TUBB/HLA-DRA/CANX/HLA-DRB1/TUBB4B/TAP1/HLA-G/CD14/TUBA1B/ITGA5/TAP2/CTSL/MRC1/HLA-DPA1/HLA-DMA/HLA-DPB1/HLA-DQA1/MSR1/FCGR2A/TUBA1C/TUBB4A/COLEC12/TUBB2A/DYNC1H1/FCGR3A/SCARB1/OLR1/HLA-DQB1/HLA-DMB/ITGAM/CYBB	8.19422786153093
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	40/666	180/9376	3.12846179512846	HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/TAPBP/HLA-DRA/NFKBIA/TNFRSF14/HLA-DRB1/LTA/TAP1/B2M/HLA-G/SRSF2/DAXX/CCL5/ITGA5/TNF/TAP2/SRSF3/HLA-DPA1/IRF9/NXF1/IFNGR2/HLA-DMA/IRF7/HLA-DPB1/HLA-DQA1/CGAS/SRSF1/SRSF7/PIK3R3/CCL2/AKT3/HLA-DQB1/HLA-DMB/RELA/FADD/SRSF6	7.97289979337233
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	17/666	44/9376	5.43925743925744	HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/HLA-DRA/HSPD1/HLA-DRB1/LTA/HLA-G/TNF/HLA-DPA1/HLA-DMA/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB	8.16136835271771
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	25/666	95/9376	3.70475738896791	JUN/LTB/CCL3/ATP6V0C/HLA-DRA/FOS/HLA-DRB1/FLT1/CCL5/TNF/CTSL/HLA-DPA1/CCL3L1/HLA-DMA/HLA-DPB1/HLA-DQA1/VEGFA/ICAM1/ANGPT1/CCL2/IL23A/CCL20/HLA-DQB1/HLA-DMB/CXCL3	7.32666622993875
Human Diseases	Immune disease	hsa05330	Allograft rejection	15/666	39/9376	5.41464541464542	HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/TNF/HLA-DPA1/HLA-DMA/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB	7.63902842535905
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	38/666	205/9376	2.60959496081447	JUN/HLA-E/HLA-A/HLA-C/HLA-B/YWHAE/HLA-F/CDC42/CHD4/NFKBIA/CCND2/HLA-G/ATF4/DDX3X/MAD1L1/CDKN1A/GTF2H1/PRKACA/ACTN4/NFKB2/REL/EGR3/ATF6B/IRF9/HRAS/IRF7/MRPS18B/CCNE1/PMAIP1/DNAJA3/GTF2H4/EGR2/PIK3R3/SCRIB/YWHAG/RELA/YWHAH/KAT2A	6.44315920921298
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	40/666	227/9376	2.48071860406662	HLA-E/HLA-A/HLA-C/HLA-B/CCL3/HLA-F/TAPBP/CCL4/NFKBIA/TAP1/B2M/HLA-G/ATF4/CCL5/MYC/CDKN1A/TNF/PRKACA/CCL4L2/TAP2/GNG10/ATF6B/HRAS/CCL3L1/IL10RB/CGAS/GNAS/ARHGEF1/VEGFA/PPP3R1/PIK3R3/CALML4/CCL2/GNAI1/AKT3/PRKCG/RELA/FADD/GNB2/E2F1	6.24471069343673
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	47/666	300/9376	2.20556556556557	JUN/HSPA1A/CDC42/NR4A1/FOS/HSPA8/DUSP8/HSPA1B/DUSP1/GADD45B/ATF4/CD14/FLT1/DAXX/DUSP16/MYC/MKNK2/TNF/PRKACA/NFKB2/JUND/DUSP9/CSF1R/HRAS/RPS6KA1/PPM1B/DUSP5/DUSP2/GADD45G/VEGFA/HSPA6/EFNA1/PDGFB/PPP3R1/FGFR1/DUSP4/ANGPT1/MAP4K1/MEF2C/PLA2G4B/AKT3/DUSP10/PRKCG/MAP2K3/RELA/CACNA2D4/DUSP6	5.86837548018003
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	15/666	45/9376	4.69269269269269	HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/TNF/HLA-DPA1/HLA-DMA/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB	6.8659241994145
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	37/666	216/9376	2.41152263374486	JUN/HSP90AA1/CCL3/HSPA1A/HSP90AB1/CDC42/FOS/HSPD1/HSPA8/NFKBIA/HSPA1B/ATF4/CD14/CCL5/TNF/HSPA4/HSPA2/HRAS/CCL3L1/LDLR/IRF7/ARHGEF1/RXRB/ICAM1/HSPA6/SOD2/PPP3R1/PIK3R3/CALML4/CCL2/OLR1/AKT3/MAP2K3/RELA/CXCL3/AGER/CYBB	5.80337534664526
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	24/666	109/9376	3.09976031076949	JUN/HSP90AA1/IL27RA/HSP90AB1/HLA-DRA/FOS/NFKBIA/HLA-DRB1/NFKBIB/AHR/HLA-DPA1/IFNGR2/HLA-DMA/HLA-DPB1/HLA-DQA1/RXRB/NFKBIE/EBI3/PPP3R1/IL23A/RARA/HLA-DQB1/HLA-DMB/RELA	6.09715260767449
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	16/666	56/9376	4.02230802230802	EEF1G/HSPA1A/HSPD1/HSPA8/NFKBIA/HSPA1B/HSF1/CD14/TNF/NFKB2/HSPA6/CLK1/RELA/CXCL3/VCP/ITGAM	6.27246803123498
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/666	78/9376	3.42927542927543	JUN/HLA-DRA/FOS/NFKBIA/HLA-DRB1/NFKBIB/TNF/HLA-DPA1/IFNGR2/HLA-DMA/HLA-DPB1/HLA-DQA1/FCGR2A/FCGR3A/HLA-DQB1/HLA-DMB/RELA/ITGAM/CYBB	5.95721073245385
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	42/666	275/9376	2.15010647010647	HSPA1A/TUBB/EGR1/NDUFA3/CSNK2B/PSMB3/PSMA2/HSPA8/C1QA/NDUFA6/HSPA1B/MT-CO1/NDUFA7/PSMC4/PSMA6/MT-ND3/TUBB4B/NDUFS3/ATF4/C1QC/C1QB/CCL5/TUBA1B/TNF/MT-CO3/PRKACA/STIP1/NDUFS1/ATF6B/MT-ND1/NDUFA13/HSPA6/TUBA1C/TUBB4A/PPP3R1/TUBB2A/MT-ATP6/PIK3R3/MT-ND5/SDHA/CYBB/MT-ATP8	5.3527074970032
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	15/666	54/9376	3.91057724391058	HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/HLA-DPA1/HLA-DMA/HLA-DPB1/HLA-DQA1/CGA/HLA-DQB1/HLA-DMB	5.93109848413547
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	17/666	70/9376	3.41896181896182	HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/HLA-DPA1/HLA-DMA/HLA-DPB1/EIF4G2/HLA-DQA1/DMD/ICAM1/HLA-DQB1/HLA-DMB	5.61707450848762
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	32/666	196/9376	2.29846172703316	PLCG2/JUN/HLA-E/HLA-A/HLA-C/HLA-B/ZFP36/HLA-F/FOS/NFKBIA/HLA-G/MYC/UBB/CDKN1A/GNG10/UBC/IRF9/HRAS/IRF7/VEGFA/ICAM1/PDGFB/PPP3R1/PIK3R3/MICB/CALML4/AKT3/RELA/CXCL3/FADD/GNB2/E2F1	5.07983403360976
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	22/666	112/9376	2.76533676533677	HSPA1A/HLA-DRA/HSPA8/NFKBIA/HSPA1B/HLA-DRB1/NFKBIB/TNF/HLA-DPA1/IFNGR2/LDLR/HLA-DMA/HLA-DPB1/HLA-DQA1/IL10RB/HSPA6/GNAI1/AKT3/HLA-DQB1/MAP2K3/HLA-DMB/RELA	5.19697920973668
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	27/666	157/9376	2.42107075228094	HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/SQSTM1/ZFP36L1/GADD45B/CCND2/HLA-G/MYC/CDKN1A/RAD50/SERPINE1/HRAS/GADD45G/PTEN/CCNE1/PPP3R1/PIK3R3/CALML4/CCNB1/AKT3/MAP2K3/RELA/SIRT1/E2F1	4.96520626977611
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	19/666	93/9376	2.87616648906972	JUN/HLA-DRA/FOS/NFKBIA/HLA-DRB1/NFKBIB/MAML1/MAF/HLA-DPA1/IFNGR2/HLA-DMA/HLA-DPB1/HLA-DQA1/NFKBIE/PPP3R1/HLA-DQB1/HLA-DMB/RELA/RUNX3	5.02785042123626
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/666	110/9376	2.68763308763309	PLCG2/LDHA/EGLN2/FLT1/MKNK2/CDKN1A/SERPINE1/EPAS1/IFNGR2/EGLN1/HMOX1/VEGFA/PIK3R3/ANGPT1/LDHC/SLC2A1/AKT3/PRKCG/RELA/CYBB/ALDOA	4.92313677415465
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	20/666	103/9376	2.73360739380157	JUN/CCL3/FOS/C1QA/NFKBIA/PPP2CA/C1QC/C1QB/CCL5/TNF/SERPINE1/IFNGR2/CCL3L1/GNAS/PIK3R3/CCL2/GNAI1/AKT3/RELA/FADD	4.89184748393348
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/666	137/9376	2.46623265601368	JUN/CTSB/FOS/NFKBIA/GADD45B/LMNA/MCL1/ATF4/DAXX/TUBA1B/TNF/CTSL/HRAS/BBC3/CTSD/GADD45G/PMAIP1/TUBA1C/PIK3R3/CTSZ/AKT3/RELA/CTSO/FADD	4.78040138126924
Human Diseases	Immune disease	hsa05310	Asthma	10/666	32/9376	4.3993993993994	PRG2/HLA-DRA/HLA-DRB1/TNF/HLA-DPA1/HLA-DMA/HLA-DPB1/HLA-DQA1/HLA-DQB1/HLA-DMB	5.3262855133312
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	36/666	268/9376	1.89108511496571	TUBB/NDUFA3/PSMB3/PSMA2/NDUFA6/MT-CO1/NDUFA7/PSMC4/PSMA6/DUSP1/MT-ND3/TUBB4B/NDUFS3/ATF4/DAXX/SLC39A1/TUBA1B/UBB/MT-CO3/PRKACA/NDUFS1/UBC/SLC39A7/MT-ND1/NDUFA13/GNAS/SLC39A4/TUBA1C/TUBB4A/TUBB2A/MT-ATP6/CALML4/MT-ND5/SDHA/GNAI1/MT-ATP8	4.09250058748502
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/666	66/9376	2.98625898625899	JUN/HLA-DRA/HLA-DRB1/TNF/MAF/HLA-DPA1/IFNGR2/HLA-DMA/HLA-DPB1/HLA-DQA1/IL23A/HLA-DQB1/HLA-DMB/RELA	4.47761426628777
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	27/666	181/9376	2.10004479617739	LSP1/ATP6V0C/HLA-DRA/HSPD1/HLA-DRB1/CD14/TNF/PLK3/MRC1/HLA-DPA1/IFNGR2/HLA-DMA/CTSD/HLA-DPB1/HLA-DQA1/IL10RB/FCGR2A/PPP3R1/FCGR3A/CALML4/IL23A/AKT3/HLA-DQB1/HLA-DMB/RELA/FADD/ITGAM	4.13225835887816
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	29/666	201/9376	2.03116549385206	GADD45B/CCND2/CD14/FLT1/FUS/MYC/CDKN1A/REL/MAF/CSF1R/KMT2A/GADD45G/BCL6/RXRB/RARA/CEBPA/JUP/MEF2C/CDK9/SPI1/RELA/MLLT1/HHEX/ETV5/ITGAM/LDB1/H3C12/DUSP6/ID2	4.08636390266621
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/666	101/9376	2.50896440995451	PLCG2/JUN/FN1/CDC42/EGR1/TNF/COL4A1/SERPINE1/PIM1/HRAS/VEGFA/ICAM1/PIK3R3/CCL2/AKT3/RELA/AGER/CYBB	4.21595920420692
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	14/666	68/9376	2.89842783960431	CD14/MYC/CSF1R/PIM1/HRAS/PIK3R3/RARA/CEBPA/JUP/AKT3/SPI1/RELA/ITGAM/DUSP6	4.34444234734939
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	30/666	214/9376	1.97356234739412	PLCG2/JUN/HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/TAPBP/FOS/NFKBIA/TAP1/B2M/SKP1/HLA-G/TNF/TAP2/GNG10/HRAS/CGAS/PPP3R1/PIK3R3/CALML4/GNAI1/CCNB1/AKT3/PRKCG/MAP2K3/RELA/FADD/GNB2	3.98372349882517
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	15/666	78/9376	2.70732270732271	JUN/FOS/C1QA/CD14/C1QC/C1QB/ITGA5/TNF/CALML4/IL23A/C2/GNAI1/RELA/ITGAM/IRF8	4.18679620814286
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	32/666	238/9376	1.8928508340273	PLCG2/RPS9/JUN/RPS18/RPL7A/RPS17/RPL36A/RPS10/RPS25/RPL17/FOS/C1QA/RPS4Y1/NFKBIA/F13A1/NFKBIB/C1QC/C1QB/TNF/IRF9/CGAS/FCGR2A/PIK3R3/CCL2/C2/NRP1/HBEGF/PRKCG/RELA/RPL36A-HNRNPH2/CYBB/RPS26	3.85794014681738
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	46/666	388/9376	1.66905049379276	TUBB/NDUFA3/CSNK2B/PSMB3/PSMA2/NDUFA6/MT-CO1/NDUFA7/PSMC4/PSMA6/MT-ND3/TUBB4B/NDUFS3/ATF4/SLC39A1/TUBA1B/TNF/MT-CO3/NDUFS1/APOE/HRAS/SLC39A7/MT-ND1/NDUFA13/CSNK1E/SLC39A4/TUBA1C/TUBB4A/PPP3R1/TUBB2A/MT-ATP6/PIK3R3/CDK5R1/CALML4/MT-ND5/SDHA/AKT3/RELA/LRP1/LRP6/AXIN2/FADD/AGER/ATG2A/CYBB/MT-ATP8	3.72183316704092
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	22/666	142/9376	2.18111068815294	PLCG2/JUN/SQSTM1/FOSB/FOS/NFKBIA/TNF/NFKB2/JUND/CSF1R/IRF9/IFNGR2/FCGR2A/PPP3R1/PIK3R3/FCGR3A/AKT3/SPI1/RELA/BTK/TYROBP/TREM2	3.9215116714933
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	21/666	133/9376	2.22285443338075	GABARAP/GADD45B/CCND2/CDKN1A/PLK3/HRAS/CSNK1E/PRKAG1/GADD45G/FOXO4/PTEN/BCL6/SOD2/PIK3R3/PLK2/GABARAPL1/CCNB1/AKT3/SIRT1/PCK2/DEPP1	3.92742392702411
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/666	115/9376	2.32594333463899	EGR1/FOS/ATF4/CDKN1A/PRKACA/JUND/ATF6B/MAFB/GNAS/ARHGEF1/RXRB/FGFR1/GNAI1/MEF2C/HBEGF/PRKCG/LRP6/MMP14/GCM1	3.95602126907467
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	25/666	173/9376	2.03440434654308	HLA-DRA/NFKBIA/HLA-DRB1/NFKBIB/DNAJB1/CCL5/TNF/HLA-DPA1/IRF9/NXF1/IFNGR2/HLA-DMA/IRF7/PABPN1/HLA-DPB1/HLA-DQA1/ICAM1/KPNA2/PIK3R3/CCL2/AKT3/HLA-DQB1/HLA-DMB/RELA/FADD	3.79719021094998
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	18/666	109/9376	2.32482023307711	JUN/SPP1/CCL3/FOS/CCL4/NFKBIA/CD14/CCL5/TNF/CCL4L2/IRF9/CCL3L1/IRF7/PIK3R3/AKT3/MAP2K3/RELA/FADD	3.84693009834341
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/666	119/9376	2.24776036540742	JUN/FOS/NFKBIA/LTA/ATF4/CCL5/TNF/ATF6B/ICAM1/PIK3R3/CCL2/AKT3/CCL20/MAP2K3/RELA/CXCL3/MMP14/PGAM5/FADD	3.78776660228513
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/666	139/9376	2.12690388229957	JUN/HSP90AA1/HSPA1A/HSP90AB1/FOS/HSPA8/HSPA1B/ATF4/FKBP4/PRKACA/ATF6B/HRAS/CTSD/GNAS/HSPA6/PIK3R3/CALML4/RARA/GNAI1/HBEGF/AKT3	3.70119936238431
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/666	93/9376	2.42203493816397	FN1/NFKBIA/GADD45B/MYC/CDKN1A/COL4A1/CKS2/TRAF4/GADD45G/PTEN/CCNE1/RXRB/PIK3R3/AKT3/RELA/E2F1	3.81084461561062
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/666	142/9376	2.0819692932369	JUN/HSP90AA1/HSP90AB1/SQSTM1/FOS/DUSP1/TNF/CTSL/HMOX1/VEGFA/ICAM1/PDGFB/ARHGEF2/PIK3R3/NPPC/CALML4/CCL2/MEF2C/AKT3/RELA/GSTM3	3.59234342232659
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	17/666	105/9376	2.27930787930788	PLCG2/LTB/CSNK2B/CCL4/NFKBIA/GADD45B/LTA/CD14/TNF/CCL4L2/NFKB2/GADD45G/ICAM1/TNFRSF13C/RELA/CXCL3/BTK	3.64518948653323
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/666	105/9376	2.27930787930788	JUN/SQSTM1/CSNK2B/GABARAP/ATF4/UBB/UBC/HRAS/TFEB/GABARAPL1/ATG9A/RELA/RABGEF1/VCP/PGAM5/RHOT2/E2F1	3.64518948653323
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/666	105/9376	2.27930787930788	PLCG2/JUN/LSP1/NFKBIA/TNF/NFKB2/PLK3/EGR3/IRF9/HRAS/EGR2/PPP3R1/PIK3R3/CALML4/IL23A/AKT3/RELA	3.64518948653323
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	23/666	163/9376	1.98647727482083	JUN/FOS/NFKBIA/ATF4/DDX3X/MYC/CDKN1A/TNF/EGR3/ATF6B/HRAS/IRF7/HSPG2/CCNE1/EGR2/PIK3R3/PCNA/AKT3/PRKCG/MAP2K3/RELA/FADD/E2F1	3.51312843193382
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/666	106/9376	2.25780497478611	HSP90AA1/HSP90AB1/NFKBIA/ATF4/CDKN1A/FOLR2/HRAS/PTEN/CCNE1/AR/PDGFB/FGFR1/PIK3R3/AKT3/RELA/ETV5/E2F1	3.60114035943011
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	21/666	144/9376	2.05305305305305	C1QA/NFKBIA/ADIPOR2/CD14/C1QC/C1QB/TNF/TRA2B/PRKAG1/ACADVL/ACACA/C2/SREBF1/SCD/AKT3/MAP2K3/RELA/CXCL3/SIRT1/TRA2A/FADD	3.52125336498185
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/666	248/9376	1.75975975975976	JUN/HSP90AA1/HSP90AB1/CDC42/TUBB/FOS/NFKBIA/TUBB4B/DYNLRB1/SKP1/GSDMD/CD14/AHNAK/TUBA1B/MYC/TNF/RHOB/HRAS/DYNLL1/SNX18/TUBA1C/TUBB4A/TUBB2A/DYNC1H1/CYFIP1/AKT3/MAP2K3/RELA/VPS11/ARPC1B/FADD	3.35295702936987
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/666	99/9376	2.27524494191161	HLA-DRA/C1QA/HLA-DRB1/C1QC/C1QB/HLA-DPA1/HLA-DMA/HLA-DPB1/HLA-DQA1/FCGR2A/ICAM1/FCGR3A/C2/HLA-DQB1/HLA-DMB/ITGAM	3.52712705264266
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/666	90/9376	2.34634634634635	JUN/FOS/CSNK2B/NFKBIA/NFKBIB/HRAS/IFNGR2/PTEN/NFKBIE/PPP3R1/PIK3R3/AKT3/PDCD1/MAP2K3/RELA	3.54876618667976
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	22/666	157/9376	1.97272431667336	JUN/CDC42/FOS/NDUFA3/NDUFA6/MT-CO1/NDUFA7/NDUFS3/ADIPOR2/ATF4/TNF/MT-CO3/NDUFS1/NDUFA13/PRKAG1/PIK3R3/MLXIP/SREBF1/SDHA/CEBPA/AKT3/RELA	3.39868853690644
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	22/666	158/9376	1.96023871973239	YWHAE/CDKN1C/GADD45B/PPP2CA/SKP1/CCND2/MAD1L1/MYC/CDKN1A/DDX11/GADD45G/CCNE1/MCM7/YWHAG/MCM4/PTTG1/PCNA/CCNB1/CDT1/MAD2L1BP/YWHAH/E2F1	3.36591450746657
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	10/666	49/9376	2.87307715879144	JUN/FOSB/ATF4/PRKACA/ATF6B/GNAS/CDK5R1/GNAI1/RELA/DLG4	3.63493287083265
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	15/666	94/9376	2.24650182096991	JUN/HSP90AA1/HSP90AB1/FOSB/FOS/NFKBIA/TNF/TRAF4/JUND/SRSF1/CCL2/CCL20/RELA/CXCL3/FADD	3.35853390799907
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	23/666	174/9376	1.86089537813676	HSP90AA1/HSPH1/DNAJA1/HSPA1A/HSP90AB1/CANX/HSPA8/HSPA1B/PPP1R15A/SKP1/ATF4/DNAJB1/HYOU1/RNF5/TUSC3/RRBP1/ATF6B/HSPA6/BCAP29/DNAJB2/TXNDC5/VCP/DNAJB11	3.16954966423489
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/666	70/9376	2.41338481338481	JUN/CDC42/EGLN2/CDKN1A/EPAS1/HRAS/EGLN1/VEGFA/PDGFB/PIK3R3/SLC2A1/AKT3	3.28202278502878
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	50/666	480/9376	1.46646646646647	SQSTM1/TUBB/NDUFA3/CSNK2B/PSMB3/PSMA2/NDUFA6/MT-CO1/NDUFA7/PSMC4/PSMA6/MT-ND3/TUBB4B/NDUFS3/ATF4/DAXX/FUS/TUBA1B/UBB/TNF/MT-CO3/NDUFS1/UBC/HRAS/MT-ND1/NDUFA13/CSNK1E/SMCR8/TUBA1C/TUBB4A/PPP3R1/TUBB2A/MT-ATP6/CDK5R1/CALML4/MT-ND5/SDHA/PRKCG/MAP2K3/RELA/LRP6/DLG4/VCP/AXIN2/FADD/AGER/ATG2A/CYBB/GPX3/MT-ATP8	2.90106417027805
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/666	62/9376	2.49772352998159	HSPA1A/HSPA8/HSPA1B/PRKACA/HRAS/PRKAG1/HSPA6/SOD2/PIK3R3/AKT3/SIRT1	3.2716968515111
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/666	71/9376	2.37939347798503	LDHA/MYC/HRAS/PTEN/TIGAR/FGFR1/PIK3R3/SLC1A5/LDHC/SLC2A1/AKT3/GLS	3.2260628879216
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/666	30/9376	3.28488488488489	TNF/FOLR2/SHMT1/TYMS/RELA/ABCC1/GGH	3.46597749930239
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	40/666	368/9376	1.53022587805196	SQSTM1/TUBB/NDUFA3/PSMB3/PSMA2/NDUFA6/CHCHD10/MT-CO1/NDUFA7/PSMC4/PSMA6/MT-ND3/TUBB4B/HNRNPA2B1/NDUFS3/ATF4/DAXX/FUS/TUBA1B/TNF/MT-CO3/NDUFS1/SRSF3/NXF1/MT-ND1/NDUFA13/SMCR8/SRSF7/TUBA1C/TUBB4A/PPP3R1/TUBB2A/MT-ATP6/MT-ND5/SDHA/MAP2K3/VCP/ATG2A/GPX3/MT-ATP8	2.86935521692212
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	21/666	160/9376	1.84774774774775	HLA-E/HLA-A/HLA-C/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/HLA-DPA1/HLA-DMA/SIGLEC1/HLA-DPB1/HLA-DQA1/ICAM1/PTPRF/PDCD1/HLA-DQB1/F11R/HLA-DMB/CLDN7/ITGAM	2.99067402133649
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/666	91/9376	2.16585816585817	PLCG2/JUN/FOS/NFKBIA/NFKBIB/INPP5D/HRAS/NFKBIE/PPP3R1/PIK3R3/AKT3/RELA/BTK/INPPL1	3.09021813116928
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	27/666	227/9376	1.67448505774497	JUN/FOS/NDUFA3/NDUFA6/NFKBIA/MT-CO1/NDUFA7/MT-ND3/NDUFS3/AHR/MT-CO3/NDUFS1/HRAS/MT-ND1/NDUFA13/HMOX1/PTEN/VEGFA/SOD2/MT-ATP6/PIK3R3/MT-ND5/SDHA/AKT3/RELA/GSTM3/MT-ATP8	2.84454050965229
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	26/666	217/9376	1.68677433193562	JUN/HSP90AA1/HSP90AB1/FOS/AHR/ATF4/MYC/KLF4/PRKACA/ATF6B/HRAS/RPS6KA1/BCL6/GNAS/RXRB/AR/VEGFA/KPNA2/PIK3R3/ADRB2/GNAI1/AKT3/PRKCG/RELA/GSTM3/E2F1	2.83030714553867
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/666	133/9376	1.90530380004064	PLCG2/HLA-E/HLA-A/HLA-C/HLA-B/HLA-G/KLRK1/TNF/HRAS/IFNGR2/NCR3/ICAM1/PPP3R1/PIK3R3/FCGR3A/MICB/PRKCG/TYROBP	2.90755114300544
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/666	76/9376	2.22285443338075	PLCG2/GADD45B/CDKN1A/HRAS/GADD45G/PTEN/PDGFB/PIK3R3/CALML4/AKT3/PRKCG/E2F1	2.95974134698131
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/666	136/9376	1.86327503974563	JUN/HSPA1A/FOS/CSNK2B/HSPA8/NFKBIA/HSPA1B/NFKBIB/CCND2/IRF9/BBC3/IRF7/CCNE1/HSPA6/PIK3R3/AKT3/RELA/FADD	2.80411827627307
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	24/666	200/9376	1.68936936936937	JUN/CDC42/TUBB/FOS/NFKBIA/TUBB4B/NFKBIB/TUBA1B/TNF/ARHGEF1/FCGR2A/TUBA1C/TUBB4A/ARHGEF2/TUBB2A/NCL/BAIAP2/CYFIP1/RELA/CLDN7/ARPC1B/EZR/ABCF2/FADD	2.72492123441429
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/666	50/9376	2.53405405405405	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DMA/HLA-DPB1/HLA-DQA1/TNFRSF13C/HLA-DQB1/HLA-DMB	3.00740304149854
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/666	87/9376	2.10362086224155	JUN/FOS/GADD45B/MYC/CDKN1A/HRAS/BBC3/GADD45G/PMAIP1/RALGDS/PIK3R3/AKT3/AXIN2	2.85962260659611
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/666	107/9376	1.97356234739412	LDHA/ATF4/PRKACA/PRKAG1/GNAS/PPP3R1/CALML4/ACACA/LDHC/CRTC2/SLC2A1/AKT3/SIRT1/PCK2/PYGL	2.80061165745019
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/666	69/9376	2.24433128780955	JUN/FOSB/FOS/ATF4/PRKACA/ATF6B/GNAS/PPP3R1/CALML4/PRKCG/SIRT1	2.86859597675049
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/666	89/9376	2.05634848331478	TUBB/TUBB4B/TUBA1B/PRKACA/HRAS/GNAS/TUBA1C/TUBB4A/PDGFB/TUBB2A/GNAI1/PRKCG/HTR2B	2.76871446032325
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/666	70/9376	2.21226941226941	NFKBIA/NFKBIB/ADIPOR2/TNF/PRKAG1/RXRB/NFKBIE/SLC2A1/AKT3/RELA/PCK2	2.81501244033702
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/666	109/9376	1.93735019423093	NFKBIA/TNF/RPS6KA1/PRKAG1/PTEN/PIK3R3/PTPRF/MLXIP/SREBF1/CRTC2/SLC2A1/AKT3/RELA/PCK2/PYGL	2.72181884367787
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	24/666	205/9376	1.64816523840914	NDUFA3/NDUFA6/MT-CO1/NDUFA7/MT-ND3/NDUFS3/MT-CO3/NDUFS1/CTSD/MT-ND1/NDUFA13/PTEN/MT-ATP6/PIK3R3/MT-ND5/SDHA/SLC2A1/AKT3/PRKCG/RELA/AGER/CYBB/PDK4/MT-ATP8	2.59458554892242
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/666	90/9376	2.0335001668335	ADIPOR2/EHMT2/ATF4/SESN2/PRKACA/ATF6B/HRAS/PRKAG1/SOD2/PIK3R3/AKT3/RELA/SIRT1	2.72415077735363
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	28/666	250/9376	1.57674474474474	HLA-E/HLA-A/HLA-C/HLA-B/ACAP1/HLA-F/HSPA1A/CDC42/VPS28/CHMP4A/HSPA8/HSPA1B/DAB2/HLA-G/FOLR2/HRAS/RUFY1/LDLR/WASHC1/HSPA6/AP2A2/CHMP1B/ARFGAP1/EHD4/SNX5/ARPC1B/EHD1/RAB11FIP1	2.55580133910859
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/666	100/9376	1.97093093093093	CCL3/CCL4/TNFRSF14/LTA/CCL5/TNF/CCL4L2/CSF1R/CCL3L1/IL10RB/CCL2/CCL20/CXCL3/CCL8	2.6991165734661
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/666	100/9376	1.97093093093093	HLA-DRA/HLA-DRB1/CD14/ITGA5/TNF/HLA-DPA1/CSF1R/HLA-DMA/HLA-DPB1/HLA-DQA1/CD24/HLA-DQB1/HLA-DMB/ITGAM	2.6991165734661
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	35/666	333/9376	1.47967787607427	HLA-E/HLA-A/HLA-C/SPP1/HLA-B/FN1/HLA-F/ATP6V0C/CDC42/CHD4/PPP2CA/CCND2/HLA-G/ITGA5/CDKN1A/TNF/COL4A1/PRKACA/MAML1/IRF9/HRAS/PTEN/HES4/GNAS/CCNE1/VEGFA/PPP2R3B/PIK3R3/SCRIB/AKT3/HES1/RELA/AXIN2/FADD/E2F1	2.46450222630234
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	22/666	187/9376	1.65624447977389	JUN/HSP90AA1/YWHAE/GPSM3/HSP90AB1/CTSB/GABARAP/NFKBIA/NFKBIB/GSDMD/CCL5/TNF/IRF9/IRF7/ATG16L1/CCL2/GABARAPL1/P2RX7/RELA/CXCL3/FADD/CYBB	2.50649022927312
Genetic Information Processing	Transcription	hsa03040	Spliceosome	27/666	243/9376	1.56423089756423	HSPA1A/DDX39B/HNRNPU/CWC25/HSPA8/HSPA1B/PRPF8/LSM2/PRPF31/PUF60/SRSF2/FUS/DHX16/RBM8A/SRSF3/PRPF38B/TRA2B/SRSF1/EIF4A3/HSPA6/RBM25/SRSF7/RBMX/TRA2A/U2AF2/ISY1/SRSF6	2.4641489040223
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/666	103/9376	1.9135251756611	DDX39B/PPP2CA/FUS/RBM8A/CPSF1/NXF1/PABPN1/PABPC4/EIF4A3/PPP2R3B/DDX19B/NUDT21/PCF11/DAZAP1	2.57776117478831
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	13/666	93/9376	1.96790338725823	JUN/CDC42/EGR1/ATF4/PRKACA/HRAS/GNAS/CGA/CALML4/HBEGF/PLA2G4B/MAP2K3/MMP14	2.59383880998497
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/666	37/9376	2.66342017693369	GADD45B/MYC/CDKN1A/HRAS/GADD45G/RXRB/NCOA4	2.8032789422715
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/666	156/9376	1.71463771463771	YWHAE/NFKBIA/PPP2CA/MYC/CDKN1A/TNF/IRF9/HRAS/LDLR/IRF7/PIK3R3/SCARB1/YWHAG/AKT3/RELA/CLDN7/FADD/YWHAH/E2F1	2.48883695148713
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/666	46/9376	2.44836140488314	PSME1/PSME2/PSMB8/PSMB3/PSMA2/PSMC4/PSMA6/PSMB9	2.72288132125086
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/666	157/9376	1.70371645530881	C1QA/DUSP8/SLC16A1/STAB1/ARG2/DUSP16/C1QC/C1QB/DUSP5/DUSP2/CD24/DUSP4/ODC1/SLC2A1/LRP1/SIRT1/VPS11/AGER/ADAM9	2.45877789718464
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/666	75/9376	2.06478478478479	GADD45B/CCND2/SESN2/CDKN1A/SERPINE1/BBC3/GADD45G/PTEN/CCNE1/PMAIP1/CCNB1	2.56000799399101
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	12/666	85/9376	1.98749337572867	NME2/IMPDH2/ADSL/PNP/AK6/GMPR2/TYMP/TYMS/AK1/TK1/NME4/AMPD2	2.52886763977834
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/666	138/9376	1.73425599512556	JUN/FN1/CDC42/FOS/NFKBIA/ITGA5/TNF/RPS6KA1/ARHGEF1/FCGR2A/PIK3R3/CCL2/BAIAP2/AKT3/MAP2K3/RELA/ARPC1B	2.40276745401559
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	32/666	308/9376	1.46265746265746	POLR2A/TUBB/NDUFA3/PSMB3/PSMA2/NDUFA6/MT-CO1/NDUFA7/PSMC4/PSMA6/MT-ND3/TUBB4B/NDUFS3/POLR2J3/TUBA1B/MT-CO3/NDUFS1/BBC3/MT-ND1/NDUFA13/AP2A2/TUBA1C/TUBB4A/SOD2/TUBB2A/MT-ATP6/MT-ND5/SDHA/DLG4/ATG2A/GPX3/MT-ATP8	2.28293133688218
NA	NA	hsa04981	Folate transport and metabolism	6/666	31/9376	2.72478930543447	FOLR2/MTHFS/SLCO2B1/SHMT1/TYMS/ABCC1	2.65975062742424
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	13/666	98/9376	1.86750015321444	PLCG2/CDC42/MARCKS/INPP5D/FCGR2A/PIK3R3/FCGR3A/PLA2G4B/AKT3/PRKCG/VASP/ARPC1B/INPPL1	2.38709162566479
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	16/666	130/9376	1.73268653268653	JUN/FOS/NFKBIA/ATF4/COL4A1/PRKACA/GNG10/ATF6B/HRAS/GNAS/VEGFA/PIK3R3/GNAI1/AKT3/RELA/GNB2	2.32609054421041
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/666	59/9376	2.14750343563903	PRKACA/ABHD5/GNAS/PNPLA2/PIK3R3/CGA/ADRB2/GNAI1/AKT3	2.44486919119746
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/666	59/9376	2.14750343563903	GADD45B/MYC/CDKN1A/HRAS/GADD45G/PTEN/PIK3R3/AKT3/AXIN2	2.44486919119746
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/666	32/9376	2.63963963963964	GABARAP/PPP2CA/ATG16L1/GABARAPL1/ATG9A/ATG2A	2.56903877233113
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/666	41/9376	2.40357430601333	MYC/CDKN1A/HRAS/TYMP/VEGFA/HBEGF/E2F1	2.49048454993981
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	36/666	362/9376	1.40002986411826	HSP90AA1/SPP1/FN1/YWHAE/HSP90AB1/NR4A1/PPP2CA/MCL1/CCND2/ATF4/FLT1/MYC/ITGA5/CDKN1A/COL4A1/GNG10/CSF1R/ATF6B/HRAS/PTEN/CCNE1/VEGFA/CSH1/EFNA1/PDGFB/FGFR1/PPP2R3B/PIK3R3/ANGPT1/YWHAG/CRTC2/AKT3/RELA/PCK2/GNB2/YWHAH	2.14635521703123
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/666	143/9376	1.67361767361767	HLA-DRA/C1QA/HLA-DRB1/C1QC/C1QB/TNF/ACTN4/HLA-DPA1/HLA-DMA/HLA-DPB1/HLA-DQA1/FCGR2A/FCGR3A/C2/HLA-DQB1/HLA-DMB/H3C12	2.24452139451375
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/666	60/9376	2.11171171171171	PLCG2/CDC42/HRAS/VEGFA/PPP3R1/PIK3R3/PLA2G4B/AKT3/PRKCG	2.38872822655166
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/666	122/9376	1.73091123910796	JUN/CDC42/FOS/NFKBIA/NFKBIB/PPP2CA/TNF/HRAS/NFKBIE/PPP3R1/PPP2R3B/PIK3R3/AKT3/PDCD1/RELA	2.24695038602923
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	25/666	235/9376	1.4976678806466	NDUFA3/NDUFA6/MT-CO1/NDUFA7/MT-ND3/NDUFS3/SMARCB1/MT-CO3/PRKACA/NDUFS1/HRAS/RPS6KA1/COX16/MT-ND1/NDUFA13/PRKAG1/GNAS/PNPLA2/FGFR1/MT-ATP6/MT-ND5/SDHA/MAP2K3/MT-ATP8/SMARCD2	2.13643834606936
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/666	71/9376	1.98282789832086	PLCG2/JUN/ATP6V0C/CDC42/NFKBIA/CCL5/HBEGF/F11R/RELA/CXCL3	2.29859330103438
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/666	52/9376	2.16585816585817	PRKACA/LDLR/GNAS/CGA/HSD17B1/SCARB1/PLA2G4B/HSD17B7	2.33109478930046
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/666	103/9376	1.77684480597102	FN1/ARG2/CD14/TNF/COL4A1/PRKACA/ACTN4/GNAS/PIK3R3/PRKCG/RELA/CXCL3/ITGAM	2.19208012326412
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/666	34/9376	2.48436671966084	SKP1/CSNK1E/PRKAG1/PER1/BHLHE41/BHLHE40	2.39758719784404
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	19/666	169/9376	1.58274250581943	SQSTM1/CTSB/GABARAP/PPP2CA/UBB/PRKACA/CTSL/UBC/HRAS/CTSD/ATG16L1/PTEN/SMCR8/PIK3R3/GABARAPL1/AKT3/ATG9A/VPS11/ATG2A	2.11385236965277
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/666	238/9376	1.47878971408383	PLCG2/CDC42/RASA3/FLT1/SYNGAP1/PRKACA/REL/GNG10/CSF1R/HRAS/FOXO4/VEGFA/EFNA1/PDGFB/FGFR1/RALGDS/PIK3R3/ANGPT1/RGL2/CALML4/PLA2G4B/AKT3/PRKCG/RELA/GNB2	2.06881372503791
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/666	83/9376	1.86576938384167	CCL4/NFKBIA/NFKBIB/GSDMD/CCL5/CCL4L2/IRF7/POLR3E/CGAS/RELA/FADD	2.19067007990591
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/666	170/9376	1.5734322557852	JUN/CDC42/RAPGEF6/PPP2CA/TUBA1B/PRKACA/ACTN4/HSPA4/PRKAG1/ARHGAP17/TUBA1C/ARHGEF2/SCRIB/PCNA/F11R/CLDN7/VASP/ARPC1B/EZR	2.0863384850446
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/666	73/9376	1.92850384631207	GADD45B/CDKN1A/HRAS/GADD45G/PTEN/PDGFB/FGFR1/PIK3R3/AKT3/E2F1	2.20215204995513
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/666	73/9376	1.92850384631207	PLCG2/GADD45B/CDKN1A/HRAS/GADD45G/RXRB/PIK3R3/AKT3/PRKCG/E2F1	2.20215204995513
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	21/666	193/9376	1.53181160435046	PLCG2/CCL3/CDC42/CCL4/NFKBIA/NFKBIB/CCL5/PRKACA/CCL4L2/GNG10/HRAS/CCL3L1/PIK3R3/CCL2/GNAI1/AKT3/CCL20/RELA/CXCL3/CCL8/GNB2	2.06422886750858
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	16/666	138/9376	1.63224093658876	YWHAE/PPP2CA/SKP1/MAD1L1/PRKACA/RPS6KA1/CCNE1/AR/PPP3R1/REC8/CALML4/YWHAG/PTTG1/CCNB1/CPEB4/YWHAH	2.06893502486423
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/666	75/9376	1.87707707707708	CANX/ATF4/PRKACA/ATF6B/GNAS/ATP1B2/CGA/PRKCG/GPX3/ATP1A1	2.10871188314116
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/666	36/9376	2.34634634634635	POLD4/SSBP1/MCM7/MCM4/PCNA/POLD1	2.23793920081241
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/666	76/9376	1.85237869448396	PLTP/UBC/HMGCS1/RXRB/PLIN2/ANGPTL4/OLR1/SCD/PCK2/FABP5	2.06305868996642
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/666	98/9376	1.72384629527487	NR4A1/ATF4/PRKACA/ATF6B/LDLR/GNAS/ATP1B2/CALML4/SCARB1/PRKCG/ORAI1/ATP1A1	1.99180071993832
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	14/666	120/9376	1.64244244244244	PLCG2/JUN/YWHAE/CDC42/NFKBIA/NFKBIB/ATF4/HRAS/RPS6KA1/NFKBIE/PIK3R3/CALML4/AKT3/RELA	1.95851476445065
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/666	77/9376	1.82832182832183	CDC42/GADD45B/CDKN1A/GADD45G/VEGFA/RALGDS/PIK3R3/AKT3/RELA/E2F1	2.01808762942911
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/666	77/9376	1.82832182832183	NFKBIA/GADD45B/MYC/CDKN1A/HRAS/GADD45G/PIK3R3/AKT3/RELA/E2F1	2.01808762942911
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/666	154/9376	1.55407355407355	JUN/FOS/CDKN1A/PRKACA/HRAS/EEF2/PRKAG1/GNAS/PPP3R1/EEF2K/CALML4/GNAI1/KCNJ2/MEF2C/PLA2G4B/PRKCG/CACNA2D4	1.91702995252349
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/666	110/9376	1.66377286377286	SMAD7/PPP2CA/SKP1/ID3/ID1/NOG/MYC/TNF/TGIF2/INHBA/BAMBI/RGMB/ID2	1.93634778748578
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/666	20/9376	2.81561561561562	CYP51A1/FDFT1/SQLE/HSD17B7	2.24754023890902
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/666	122/9376	1.61551715650076	ADIPOR2/PPP2CA/EEF2/PRKAG1/PPP2R3B/PIK3R3/EEF2K/ACACA/SREBF1/CRTC2/SCD/AKT3/SIRT1/PCK2	1.89220857254149
NA	NA	hsa04517	IgSF CAM signaling	29/666	299/9376	1.36543232195406	PLCG2/CDC42/TUBB/TUBB4B/RAPGEF6/INPP5D/TUBA1B/ITGA5/ACTN4/MTSS1/DYNLL1/ICAM1/TUBA1C/TUBB4A/FGFR1/PPFIA1/TUBB2A/PIK3R3/PTPRF/NRP1/BAIAP2/AKT3/F11R/PRKCG/NRP2/ARPC1B/EZR/ITGAM/PMP22	1.77576323065206
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/666	69/9376	1.83627105366236	PLCG2/INPP5D/TNF/HRAS/PIK3R3/PLA2G4B/AKT3/MAP2K3/BTK	1.92788191015567
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/666	69/9376	1.83627105366236	CTSB/PRKACA/GNAS/PPP3R1/CALML4/ADRB2/GNAI1/KCNJ2/ORAI1	1.92788191015567
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	21/666	204/9376	1.44921391980215	PLCG2/FN1/CDC42/MYC/ITGA5/CDKN1A/TNF/PRKACA/CTSL/TIMP3/HRAS/HSPG2/ARHGEF1/VEGFA/FGFR1/PIK3R3/HBEGF/AKT3/PRKCG/EZR/TFAP4	1.79370054979078
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	14/666	125/9376	1.57674474474474	PPP2CA/TNF/HRAS/CTSD/PTEN/PPP2R3B/PIK3R3/SGPP1/GNAI1/AKT3/PRKCG/RELA/ABCC1/S1PR2	1.79497327673978
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/666	148/9376	1.52195438681925	JUN/FOS/GADD45B/MYC/CDKN1A/NFKB2/HRAS/GADD45G/PTEN/FGFR1/PIK3R3/AKT3/HES1/LRP6/AXIN2/E2F1	1.76979633768682
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/666	71/9376	1.78454510848877	FOS/CCND2/HRAS/GALT/PIK3R3/CGA/AKT3/RELA/SOCS7	1.83485850759077
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/666	138/9376	1.53022587805196	ATP6V0C/NDUFA3/NDUFA6/MT-CO1/NDUFA7/MT-ND3/NDUFS3/MT-CO3/NDUFS1/MT-ND1/NDUFA13/MT-ATP6/MT-ND5/SDHA/MT-ATP8	1.73510259571287
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/666	116/9376	1.57771564668116	PLCG2/CDC42/ACTN4/ICAM1/PIK3R3/GNAI1/F11R/PRKCG/CLDN7/VASP/EZR/ITGAM/CYBB	1.73121619667725
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/666	83/9376	1.69615398531061	CSNK2B/SKP1/PHF1/RYBP/RING1/EPOP/BCOR/EZH2/MBD6/CBX8	1.76148953184294
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/666	52/9376	1.8951258951259	PLTP/APOC2/APOE/LDLR/SCARB1/ANGPTL4/LRP1	1.78977458064975
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/666	212/9376	1.39452660207377	CDC42/RAPGEF6/ID1/FLT1/CSF1R/HRAS/GNAS/VEGFA/EFNA1/PDGFB/FGFR1/RALGDS/PIK3R3/ANGPT1/CALML4/GNAI1/AKT3/PRKCG/MAP2K3/VASP/ITGAM	1.60662809641497
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/666	23/9376	2.44836140488314	POLD4/SSBP1/PCNA/POLD1	1.92299904953046
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/666	23/9376	2.44836140488314	ATP1B2/GLS/PCK2/ATP1A1	1.92299904953046
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	16/666	155/9376	1.45322096289838	NR4A1/AHR/ATF4/CDKN1A/PRKACA/ATF6B/LDLR/KMT2A/GNAS/CCNE1/RASD1/SCARB1/GNAI1/AXIN2/ORAI1/E2F1	1.57326000578453
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/666	54/9376	1.82493604715827	LDHA/ADI1/AMD1/AHCY/LDHC/MAT2A/KYAT1	1.6810331864738
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/666	65/9376	1.73268653268653	NR4A1/ATF4/PRKACA/ATF6B/LDLR/GNAS/SCARB1/ORAI1	1.63904319580877
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/666	76/9376	1.66714082503556	PRKACA/GNAS/ATP1B2/CALML4/GNAI1/KCNJ2/PRKCG/EZR/ATP1A1	1.61471736145898
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	24/666	253/9376	1.33546985720899	PLCG2/JUN/CDC42/SQSTM1/NFKBIA/NFKBIB/SKP1/CD14/CCL5/UBB/ITGA5/TNF/ACTN4/UBC/ATG16L1/FOXO4/CGAS/ARHGEF2/PIK3R3/AKT3/RELA/TIFA/ARPC1B/H3C12	1.49574859052262
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	16/666	157/9376	1.43470859394426	SMAD7/YWHAE/PPP2CA/CCND2/ID1/MYC/SERPINE1/BBC3/CSNK1E/SCRIB/YWHAG/DLG5/DLG4/AXIN2/YWHAH/ID2	1.51886725746284
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/666	122/9376	1.50012307389357	PLCG2/MYC/PRKACA/DIO2/HRAS/RXRB/ATP1B2/PIK3R3/SLC2A1/AKT3/PRKCG/ATP1A1/KAT2A	1.53746675905374
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/666	122/9376	1.50012307389357	PLCG2/FOS/ATF4/PRKACA/ATF6B/HRAS/GNAS/CSH1/PIK3R3/GNAI1/AKT3/PRKCG/MAP2K3	1.53746675905374
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	17/666	170/9376	1.40780780780781	PLCG2/GADD45B/SMARCB1/MYC/CDKN1A/HRAS/HMOX1/GADD45G/PTEN/PIK3R3/AKT3/PRKCG/GSTM3/LRP6/AXIN2/E2F1/SMARCD2	1.48374130570328
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/666	89/9376	1.58180652562675	GABARAP/SLC38A2/PRKACA/GNG10/GLUL/GABARAPL1/GNAI1/GLS/PRKCG/GNB2	1.52492872007391
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/666	78/9376	1.62439362439362	PLCG2/INPP5D/ITPK1/PIP4K2B/PTEN/TPI1/ISYNA1/PI4K2A/INPPL1	1.53117442167638
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/666	149/9376	1.41725618235685	NDUFA3/NDUFA6/NDUFA7/MT-ND3/NDUFS3/PRKACA/NDUFS1/GNG10/MT-ND1/NDUFA13/MT-ND5/GNAI1/PRKCG/NAPEPLD/GNB2	1.41964360158581
Organismal Systems	Immune system	hsa04611	Platelet activation	13/666	126/9376	1.45250011916679	PLCG2/PRKACA/GNAS/ARHGEF1/FCGR2A/PTGIR/PIK3R3/GNAI1/PLA2G4B/AKT3/VASP/BTK/ORAI1	1.41399143687611
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/666	138/9376	1.42821081951517	FLOT1/MKNK2/PRKACA/HRAS/PRKAG1/PIK3R3/PTPRF/CALML4/ACACA/SREBF1/AKT3/PCK2/PYGL/INPPL1	1.40127016656152
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/666	116/9376	1.45635290462877	SLC38A2/PRKACA/GNG10/GLUL/GNAS/PPP3R1/GNAI1/PLA2G4B/GLS/PRKCG/DLG4/GNB2	1.36753356851705
NA	NA	hsa03272	Virion - Hepatitis viruses	6/666	48/9376	1.75975975975976	CHMP4A/LDLR/HSPG2/CHMP1B/SCARB1/CLDN7	1.45920501284825
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/666	38/9376	1.85237869448396	NAPRT/SIRT2/PNP/SIRT1/NMRK1	1.45583154221738
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/666	38/9376	1.85237869448396	TAP1/TAP2/TNFRSF13C/BTK/ORAI1	1.45583154221738
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/666	18/9376	2.34634634634635	NEU1/HEXB/MAN2B1	1.58093932896314
NA	NA	hsa04518	Integrin signaling	15/666	154/9376	1.37124137124137	SPP1/FN1/CDC42/CCND2/FLT1/ITGA5/COL4A1/ACTN4/VEGFA/ICAM1/PDGFB/PIK3R3/AKT3/ICAM4/ITGAM	1.28445189822419
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/666	39/9376	1.8048818048818	MTHFS/AHCY/SHMT1/TYMS/MAT2A	1.3927539834001
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/666	168/9376	1.34076934076934	IL27RA/MCL1/CCND2/MYC/CDKN1A/PIM1/IRF9/HRAS/IFNGR2/IL10RB/CSH1/PDGFB/PIK3R3/IL23A/AKT3/SOCS7	1.23238435098741
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/666	50/9376	1.68936936936937	AOC1/ARG2/SAT1/AMD1/GATM/ODC1	1.35145924791795
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/666	50/9376	1.68936936936937	KLRK1/TNF/ICAM1/CCL2/LRP1/HBA1	1.35145924791795
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	13/666	133/9376	1.3760527444738	FOS/PPP2CA/ATF4/PRKACA/GNG10/ATF6B/GNAS/PPP2R3B/CALML4/GNAI1/AKT3/PRKCG/GNB2	1.20776316964099
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	10/666	97/9376	1.45134825547197	FOS/PRKACA/GNG10/GNAS/RASD1/PER1/CALML4/GNAI1/PRKCG/GNB2	1.23555113286284
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/666	86/9376	1.4732872407291	PLCG2/JUN/MYC/CDKN1A/HRAS/PIK3R3/HBEGF/AKT3/PRKCG	1.21921371790707
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/666	98/9376	1.43653857939572	PLCG2/INPP5D/ITPK1/PIP4K2B/PTEN/PIK3R3/CALML4/PRKCG/PI4K2A/INPPL1	1.20121890848536
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/666	63/9376	1.56423089756423	EHMT2/KMT2A/KMT5A/KMT5C/EZH2/PLOD2/COLGALT1	1.24249890075382
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/666	63/9376	1.56423089756423	POLR2A/POLD4/POLR2J3/GTF2H1/GTF2H4/PCNA/POLD1	1.24249890075382
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/666	298/9376	1.22828869137594	LTB/IL27RA/CCL3/CCL4/TNFRSF14/LTA/CCL5/TNF/CCL4L2/RELT/CSF1R/IFNGR2/CCL3L1/TNFRSF25/INHBA/IL10RB/CSH1/EBI3/CCL2/IL23A/GDF11/TNFRSF13C/TNFSF9/CCL20/CXCL3/CCL8	1.10741682306067
Genetic Information Processing	Translation	hsa03010	Ribosome	20/666	222/9376	1.26829532234938	RPS9/RPS18/RPL7A/RPS17/RPL36A/RPS10/RPS25/RPL17/RPS4Y1/MRPS24/MRPS12/MRPL45/MRPL23/MRPL38/MRPS18B/MRPL18/MRPL46/RPL36A-HNRNPH2/MRPL32/RPS26	1.11865922761632
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/666	41/9376	1.71683879000952	POLD4/RAD50/SSBP1/TOP3A/POLD1	1.27194970987115
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/666	99/9376	1.42202808869476	JUN/FOS/CDKN1A/PRKACA/HRAS/GNAS/PIK3R3/HBEGF/AKT3/E2F1	1.16726335442585
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/666	99/9376	1.42202808869476	JUN/FOS/CHKB/HRAS/PDGFB/RALGDS/PIK3R3/PLA2G4B/AKT3/PRKCG	1.16726335442585
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/666	88/9376	1.43980343980344	C1QA/F13A1/SERPINE2/C1QC/C1QB/SERPINE1/VSIG4/C2/ITGAM	1.1461792179538
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/666	53/9376	1.59374468808431	PRKACA/GNAS/AP2A2/ATP1B2/PRKCG/ATP1A1	1.1985978800313
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	22/666	250/9376	1.23887087087087	ATP6V0C/CTSB/CLN8/IDS/NEU1/LGMN/PSAP/BORCS5/CTSL/HEXB/CTSD/TFEB/CD68/AP2A2/CTSZ/SLC2A6/CTSO/CLN3/VPS11/PPT2/MAN2B1/BORCS6	1.05853845606518
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/666	42/9376	1.67596167596168	FTL/SAT1/HMOX1/NCOA4/CYBB	1.21402183047186
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/666	78/9376	1.44390544390544	HSPD1/LSM2/BTG2/TOB2/CNOT3/PABPC4/PARN/EXOSC4	1.08857079059864
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/666	32/9376	1.75975975975976	LDHA/ACACA/BCKDHA/LDHC	1.19041540183109
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/666	115/9376	1.34659877268573	FOS/ATF4/PRKACA/GNG10/HRAS/PIK3R3/GNAI1/KCNJ2/AKT3/PRKCG/GNB2	1.03409556106954
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	18/666	203/9376	1.2483024896818	JUN/SPP1/FN1/CDC42/CCND2/FLT1/ZYX/ITGA5/COL4A1/ACTN4/HRAS/PTEN/VEGFA/PDGFB/PIK3R3/AKT3/PRKCG/VASP	0.988979004033371
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/666	67/9376	1.47084397830666	ATF4/PRKACA/HRAS/RPS6KA1/PPP3R1/CALML4/PRKCG	1.06948964009333
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	16/666	178/9376	1.2654452205014	JUN/CSNK2B/NOTUM/SKP1/CCND2/MYC/PRKACA/CACYBP/CSNK1E/BAMBI/PPP3R1/SFRP1/PRKCG/SIRT1/LRP6/AXIN2	0.988671201128872
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/666	44/9376	1.5997815997816	MGAT4B/TUSC3/HEXB/ALG9/MGAT1	1.10267057812686
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/666	44/9376	1.5997815997816	POLD4/PCNA/MUTYH/POLD1/POLG2	1.10267057812686
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/666	154/9376	1.27982527982528	PPP2CA/ATF4/PRKACA/ATF6B/GNAS/ATP1B2/PPP2R3B/TPM1/CALML4/ADRB2/GNAI1/AKT3/CACNA2D4/ATP1A1	0.968162871074542
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/666	80/9376	1.40780780780781	PLCG2/HRAS/PTEN/VEGFA/PDGFB/PIK3R3/AKT3/PRKCG	1.01289901241372
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	27/666	323/9376	1.1768052882604	PLCG2/MCL1/CCND2/MARCKS/MYC/ITGA5/CDKN1A/TIMP3/PIM1/HRAS/FSCN1/HMOX1/PTEN/ZEB2/CCNE1/VEGFA/EFNA1/PDGFB/PIK3R3/TPM1/EZH2/GLS/PRKCG/SIRT1/EZR/ABCC1/E2F1	0.89415730079773
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/666	168/9376	1.25697125697126	HSP90AA1/HSP90AB1/SQSTM1/CHMP4A/FTL/TNF/IRF9/IFNGR2/GLUL/CHMP1B/PLA2G4B/PYGL/PGAM5/FADD/CYBB	0.929330540799149
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/666	23/9376	1.83627105366236	ARG2/GLUL/GLS	1.11032262798545
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/666	72/9376	1.3687020353687	NFKBIA/NFKBIB/DDX3X/TNF/IRF7/RELA/FADD	0.868401585515915
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/666	60/9376	1.40780780780781	PPP2CA/HRAS/GNAS/GNAI1/PLA2G4B/PRKCG	0.876254168464924
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/666	110/9376	1.27982527982528	HSP90AA1/HSP90AB1/MAD1L1/PRKACA/RPS6KA1/PIK3R3/GNAI1/CCNB1/AKT3/CPEB4	0.816301917484959
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/666	73/9376	1.34995269241845	CHMP4A/SMARCB1/SUPT4H1/NELFE/CDK9/MLLT1/KAT2A	0.829990141729135
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/666	61/9376	1.38472899128637	HMOX2/FTL/HMOX1/SLC39A4/ATP1B2/ATP1A1	0.833570001793159
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/666	86/9376	1.30958865842587	ATF4/PRKACA/ATF6B/GNAS/ATP1B2/SLC2A1/PRKCG/ATP1A1	0.797517251214703
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/666	37/9376	1.52195438681925	TNF/ICAM1/PRKCG/HBA1	0.879623658343403
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/666	150/9376	1.2201001001001	GADD45B/MYC/CDKN1A/HRAS/GADD45G/CCNE1/RXRB/PIK3R3/JUP/AKT3/LRP6/AXIN2/E2F1	0.751402818462839
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/666	99/9376	1.27982527982528	PLCG2/PRKACA/GNAS/PIK3R3/CALML4/PLA2G4B/PRKCG/MAP2K3/HTR2B	0.773952738056386
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/666	26/9376	1.62439362439362	MAFA/HES1/HHEX	0.881562288650608
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/666	75/9376	1.31395395395395	CDKN1A/BBC3/PMAIP1/PIK3R3/AKT3/GSTM3/FADD	0.75482355059164
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/666	38/9376	1.48190295558717	ATP1B2/PIK3R3/PRKCG/ATP1A1	0.823072570409937
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/666	15/9376	1.87707707707708	HEXB/ST6GALNAC6	0.940017508679002
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/666	140/9376	1.20669240669241	SPP1/EGR1/SERPINE1/PRKACA/GNG10/HRAS/PRKAG1/CALML4/GNAI1/MEF2C/AKT3/GNB2	0.681334300354066
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/666	115/9376	1.22418070244157	DUSP1/PRKACA/GNG10/HRAS/GNAS/GNAI1/PLA2G4B/PRKCG/HTR2B/GNB2	0.668854847568901
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/666	65/9376	1.2995148995149	SPP1/HRAS/PIK3R3/CGA/AKT3/PRKCG	0.670024404970568
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/666	144/9376	1.17317317317317	ID3/ID1/MYC/KLF4/DUSP9/HRAS/INHBA/FGFR1/PIK3R3/AKT3/AXIN2/ID2	0.579065429792643
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/666	67/9376	1.26072340997714	LDHA/TPI1/LDHC/PCK2/GPI/ALDOA	0.592215253348206
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/666	93/9376	1.21101746908199	PRKACA/GNAS/ATP1B2/CALML4/ADRB2/PRKCG/PRH1/ATP1A1	0.565495800608901
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/666	17/9376	1.65624447977389	PCDH9/NRP2	0.748840070595378
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/666	56/9376	1.25697125697126	MGAT4B/TUSC3/ALG9/MGAT1/SRD5A3	0.533315592719625
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/666	18/9376	1.56423089756423	HSD17B8/ACACA	0.662544834021479
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/666	83/9376	1.18730778971743	ECH1/DHRS4/PHYH/SOD2/PEX5/PEX6/DECR2	0.473947887654015
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/666	57/9376	1.23491912965597	HSD17B8/ACADVL/ACACA/SCD/PPT2	0.49190907012147
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/666	44/9376	1.27982527982528	PRKACA/DYNLL1/GNAS/DYNC1H1	0.514445763577618
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/666	19/9376	1.48190295558717	IDS/HEXB	0.581409000961577
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/666	32/9376	1.31981981981982	BBC3/PMAIP1/FADD	0.501103716581072
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/666	59/9376	1.1930574642439	NME2/TYMP/TYMS/TK1/NME4	0.411327959290839
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/666	59/9376	1.1930574642439	HPGDS/ODC1/CHAC1/GSTM3/GPX3	0.411327959290839
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	12/666	154/9376	1.0969930969931	NME2/NAPRT/ADSL/AK6/ALAS1/SHMT1/AK1/RDH13/PDXP/NME4/MAT2A/GGH	0.335584816775245
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/666	46/9376	1.22418070244157	HMOX2/FTL/HMOX1/ALAS1	0.421453820299984
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/666	47/9376	1.19813430451728	LDHA/ACACA/LDHC/PCK2	0.376534463485518
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/666	34/9376	1.24218335983042	POLR2A/POLR2J3/POLR3E	0.391180774514361
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/666	75/9376	1.12624624624625	ARG2/GLUL/TPI1/SHMT1/MAT2A/ALDOA	0.303527439741798
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/666	48/9376	1.17317317317317	ATP1B2/PIK3R3/AKT3/ATP1A1	0.332598771044462
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/666	117/9376	1.08292908292908	CHD4/INO80D/SMARCB1/INO80B/SRCAP/TFPT/CHD3/MTA2/SMARCD2	0.249592440098461
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/666	35/9376	1.20669240669241	TIGAR/TPI1/ALDOA	0.338747059157265
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/666	90/9376	1.09496162829496	PRKACA/LDLR/GNAS/ATP1B2/SCARB1/SLC2A1/ATP1A1	0.250304549375232
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/666	22/9376	1.27982527982528	AOC1/HNMT	0.363340056705643
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/666	105/9376	1.07261547261547	LMNA/ITGA5/TNF/PRKACA/GNAS/DMD/TPM1/CACNA2D4	0.206906532523482
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/666	36/9376	1.17317317317317	PGM2L1/PYGL/GPI	0.287853889769923
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/666	36/9376	1.17317317317317	C1GALT1C1/GALNT4/ST6GALNAC1	0.287853889769923
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	17/666	232/9376	1.03158330744538	FN1/CDC42/ITGA5/ACTN4/HRAS/PIP4K2B/ARHGEF1/PDGFB/FGFR1/PIK3R3/BAIAP2/CYFIP1/AKT3/SPATA13/ARPC1B/EZR/ITGAM	0.13469366400493
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/666	23/9376	1.22418070244157	HMGCS1/FNTB	0.297646206440441
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/666	93/9376	1.05964028544674	CDC42/CSNK2B/ACTN4/SNAI1/FGFR1/PTPRF/BAIAP2	0.159827198733686
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/666	65/9376	1.08292908292908	AGPAT5/DGAT1/ABHD16A/PNPLA2/AGPAT1	0.185515009551468
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/666	37/9376	1.14146579011444	ADSL/GLUL/GLS	0.238405230367369
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/666	51/9376	1.10416298651593	PLCG2/ATP6V0C/PRKACA/GNAS	0.206247059946746
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/666	38/9376	1.11142721669037	HEXB/GALT/GPI	0.190313598602494
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/666	166/9376	1.01769239118637	ATF4/ATF6B/ATP1B2/PPP3R1/NPPC/CALML4/ADRB2/GNAI1/MEF2C/AKT3/VASP/ATP1A1	0.0635952146396142
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/666	82/9376	1.03010327400571	NME2/IMPDH2/TYMP/TK1/NME4/GSTM3	0.0757064704256191
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/666	55/9376	1.02386022386022	NEU1/PSAP/HEXB/SGPP1	0.0490725108836353
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/666	26/9376	1.08292908292908	SCARB1/ABCC1	0.117085039447121
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/666	99/9376	0.995419662086329	LMNA/ITGA5/TNF/PRKAG1/DMD/TPM1/CACNA2D4	-0.012668494682549
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	9/666	128/9376	0.989864864864865	NME2/IMPDH2/ADSL/PNP/AK6/GMPR2/AK1/NME4/AMPD2	-0.0319245139033563
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/666	41/9376	1.03010327400571	GATM/ALAS1/SHMT1	0.0534148698024977
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/666	27/9376	1.04282059837615	HMGCS1/BDH1	0.0616120571110031
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/666	87/9376	0.970901936419178	MT-CO1/MT-CO3/ATP1B2/TPM1/CACNA2D4/ATP1A1	-0.0753967990917497
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/666	233/9376	0.966734975318666	FN1/LMNA/ZYX/ITGA5/COL4A1/HSPG2/FBLN1/DMD/ATP1B2/TPM1/CSRP2/JUP/LMOD3/AMPD2/MYOM2/ATP1A1	-0.142178892154837
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/666	43/9376	0.982191493819401	DGAT1/AGPAT1/SCARB1	-0.0323641914449892
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/666	28/9376	1.00557700557701	ATP6V0C/SLC12A7	0.00817211402860955
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/666	44/9376	0.95986895986896	TAF9/GTF2H1/GTF2H4	-0.0737790509716193
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/666	104/9376	0.947562947562948	AGPAT5/CHKB/CRLS1/LPCAT1/MBOAT7/AGPAT1/PLA2G4B	-0.148690049088457
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/666	13/9376	1.08292908292908	RAD50	0.0827341296416591
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/666	134/9376	0.945542557482856	PRKACA/GNAS/ARHGEF1/PTGIR/NPPC/CALML4/ADM/PLA2G4B/PRKCG	-0.175565967489736
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/666	29/9376	0.970901936419178	CSNK1E/RASSF4	-0.0433950947930496
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/666	149/9376	0.944837454904569	PLCG2/AGPAT5/HRAS/GNAS/PDGFB/RALGDS/PIK3R3/AGPAT1/PLA2G4B/AKT3	-0.187681231586744
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/666	45/9376	0.938538538538538	TAP1/TAP2/ABCC1	-0.114276970952575
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/666	91/9376	0.928224928224928	PRKACA/GNG10/GNAS/GNAI1/PRKCG/GNB2	-0.190246665212522
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	13/666	195/9376	0.938538538538538	PLCG2/GSDMD/FCGR2A/PIK3R3/FCGR3A/AKT3/PRKCG/RELA/AGER/ITGAM/PADI4/CYBB/H3C12	-0.239821917011624
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/666	30/9376	0.938538538538538	SDHA/PCK2	-0.0932318489692311
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/666	14/9376	1.00557700557701	B4GALT4	0.0057742349823942
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	15/666	226/9376	0.934385713146775	JUN/FOS/NFKBIA/PRKACA/GNAS/ATP1B2/PIK3R3/CGA/CALML4/ADRB2/GNAI1/AKT3/RELA/ORAI1/ATP1A1	-0.276093232034267
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/666	62/9376	0.908263101811489	MAML1/NRARP/HES1/KAT2A	-0.200394341787789
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/666	108/9376	0.912468023579135	DDX39B/RBM8A/NXF1/EIF4A3/KPNA2/DDX19B/IPO4	-0.252987623350321
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/666	31/9376	0.908263101811489	GPI/ALDOA	-0.141464972994707
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/666	31/9376	0.908263101811489	GLUL/SHMT1	-0.141464972994707
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/666	78/9376	0.902440902440902	FN1/CDC42/ITGA5/PIK3R3/ARPC1B	-0.239240102634601
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/666	47/9376	0.898600728387962	TNF/MAFA/PIK3R3	-0.192699191728964
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/666	63/9376	0.89384622717956	GADD45B/CDKN1A/GADD45G/AXIN2	-0.233762359717729
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/666	184/9376	0.918135526831179	PLCG2/CDC42/HRAS/RND1/EFNA1/EPHB6/PPP3R1/PIK3R3/GNAI1/NRP1/EFNB2/SEMA7A	-0.310108057248613
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/666	15/9376	0.938538538538538	AK1	-0.0658720326784875
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/666	49/9376	0.861923147637433	C1GALT1C1/GALNT4/COLGALT1	-0.26795483944593
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/666	16/9376	0.87987987987988	MIF	-0.132969336002309
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/666	16/9376	0.87987987987988	HEXB	-0.132969336002309
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	10/666	158/9376	0.891017599878359	SESN2/TNF/HRAS/RPS6KA1/PTEN/PIK3R3/AKT3/CASTOR1/PRKCG/LRP6	-0.382014840778539
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/666	66/9376	0.853216853216853	HSD17B8/HSD17B1/HSD17B7/SRD5A3	-0.330892555620203
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/666	144/9376	0.87987987987988	PSMB3/PSMA2/PSMC4/PSMA6/PIK3R3/NOP56/AKT3/PRKCG/ATG2A	-0.401663881937093
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/666	17/9376	0.828122239886946	KYAT1	-0.196129579727942
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/666	17/9376	0.828122239886946	GLUL	-0.196129579727942
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/666	68/9376	0.828122239886946	DHRS4/DGAT1/RDH13/RDH10	-0.393332316364656
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	16/666	254/9376	0.88680806791043	PLCG2/FLT1/PRKACA/GNAS/TFEB/VEGFA/PDGFB/PPP3R1/FGFR1/CALML4/P2RX7/ADRB2/P2RX5/PRKCG/HTR2B/ORAI1	-0.505709337578469
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/666	101/9376	0.836321469984836	PRKACA/HRAS/GNAS/CALML4/GNAI1/PRKCG	-0.457308337159053
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/666	194/9376	0.87080895328318	TUBB/TUBB4B/DYNLRB1/TUBA1B/DYNLL1/MYO19/TUBA1C/TUBB4A/TUBB2A/DYNC1H1/TPM1/KIFC1	-0.502780369697099
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/666	86/9376	0.818492911516167	LMNA/ITGA5/DMD/JUP/CACNA2D4	-0.467572148862399
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/666	37/9376	0.760977193409626	GALT/GPI	-0.402813197608664
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/666	19/9376	0.740951477793583	BCKDHA	-0.312538324885544
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/666	89/9376	0.790903262813375	SPP1/FN1/ITGA5/COL4A1/HSPG2	-0.548047513674998
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/666	56/9376	0.754182754182754	CCND2/PRKACA/CSNK1E	-0.510166668828623
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/666	20/9376	0.703903903903904	NPL	-0.366535672438686
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/666	191/9376	0.810779365753188	FOSB/ATF4/PRKACA/GNG10/ATF6B/HRAS/GNAS/CALML4/GNAI1/GNB2/H3C12	-0.730565690204771
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/666	42/9376	0.67038467038467	AOC1/KYAT1	-0.591986528292287
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/666	23/9376	0.612090351220786	B3GALNT2	-0.515030215104571
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/666	24/9376	0.586586586586587	NDST2	-0.56072718313095
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/666	63/9376	0.67038467038467	HPGDS/PRXL2B/PLA2G4B	-0.725849446541579
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/666	26/9376	0.541464541464541	PLA2G4B	-0.647392209756366
NA	NA	hsa04081	Hormone signaling	12/666	219/9376	0.771401538524826	ADIPOR2/PRKACA/GNG10/DIO2/GNAS/CSH1/PIK3R3/CGA/NPPC/ADRB2/GNAI1/GNB2	-0.946525740043111
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/666	27/9376	0.521410299188077	SCD	-0.688614757788692
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/666	48/9376	0.586586586586587	HMGCS1/BCKDHA	-0.794007470759323
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/666	103/9376	0.683401848450392	SLC38A2/COL4A1/ATP1B2/SLC1A5/ATP1A1	-0.893368288929444
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/666	28/9376	0.502788502788503	PPT2	-0.728575396858344
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/666	28/9376	0.502788502788503	B4GALT4	-0.728575396858344
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/666	28/9376	0.502788502788503	GGH	-0.728575396858344
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/666	29/9376	0.485450968209589	CALML4	-0.767367352408057
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/666	70/9376	0.603346203346203	HPGDS/SULT1A3/GSTM3	-0.921070317197114
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/666	51/9376	0.552081493257964	LPCAT1/PLA2G4B	-0.886897334660767
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/666	30/9376	0.469269269269269	PLA2G4B	-0.805073718623556
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/666	31/9376	0.454131550905744	BAG6	-0.841768873099444
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/666	54/9376	0.521410299188077	HES1/TOP3A	-0.97525762456475
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/666	32/9376	0.43993993993994	GALT	-0.877519653918966
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/666	33/9376	0.426608426608427	BCKDHA	-0.912386345278907
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/666	33/9376	0.426608426608427	STX16	-0.912386345278907
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/666	116/9376	0.606813710261986	TPI1/SHMT1/SDHA/GPI/ALDOA	-1.17824482860432
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/666	37/9376	0.380488596704813	MIF	-1.0440316255847
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/666	102/9376	0.552081493257964	GNAS/ATP1B2/PRKCG/ATP1A1	-1.25770625852473
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/666	142/9376	0.594848369496257	SKP1/UBB/HERC2/UBC/HERC3/UBE2S	-1.34518031517401
NA	NA	hsa04082	Neuroactive ligand signaling	9/666	199/9376	0.636696998506044	PRKACA/GNG10/GNAS/ADRB2/GNAI1/P2RX5/PRKCG/HTR2B/GNB2	-1.43238192972652
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/666	183/9376	0.615435107238386	FBL/CSNK2B/AK6/NXF1/RMRP/GNL3/NOP56/LSG1	-1.45271434387561
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/666	43/9376	0.327397164606467	ACADVL	-1.222351089438
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/666	73/9376	0.385700769262413	HPGDS/GSTM3	-1.45694637198086
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/666	79/9376	0.356407039951344	HPGDS/GSTM3	-1.58842637747154
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/666	79/9376	0.356407039951344	ATP6V0C/AP2A2	-1.58842637747154
NA	NA	hsa04519	Cadherin signaling	19/666	404/9376	0.662087830404662	YWHAE/CDC42/NFKBIA/FMN1/ACTN4/HRAS/KRT7/FGFR1/YWHAG/PCDH9/JUP/CYFIP1/MAP2K3/RELA/VASP/LRP6/ARPC1B/AXIN2/YWHAH	-1.91983346709845
NA	NA	hsa04382	Cornified envelope formation	8/666	217/9376	0.519007486749422	PPP2CA/COL4A1/ABHD5/KRT7/PPP2R3B/JUP/CLDN7/S100A11	-1.98224727381239
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/666	86/9376	0.163698582303233	PRKACA	-2.15435801563187
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/666	370/9376	0.418537456375294	CSH1/PTGIR/CGA/P2RX7/CHRNB1/ADRB2/ADM/P2RX5/HTR2B/LTB4R/S1PR2	-3.15551544192921
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/666	449/9376	0.0627085883210605	PRKACA/CALML4	-5.62805996493345