ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0045296 cadherin binding 94/2506 334/18639 0.281437125748503 2.09325881357795 7.85427598876215e-13 9.90424202182907e-10 GO:0044389 ubiquitin-like protein ligase binding 88/2506 322/18639 0.273291925465839 2.03267685505098 2.38262208497082e-11 1.06348959392522e-08 GO:0031625 ubiquitin protein ligase binding 84/2506 302/18639 0.278145695364238 2.06877797920752 2.53011005691963e-11 1.06348959392522e-08 GO:0140658 ATP-dependent chromatin remodeler activity 51/2506 158/18639 0.322784810126582 2.4007925283118 8.16026663489301e-10 2.57252405665002e-07 GO:0140104 molecular carrier activity 69/2506 249/18639 0.27710843373494 2.06106308714507 1.77342757044719e-09 4.47258433266782e-07 GO:0140297 DNA-binding transcription factor binding 113/2506 488/18639 0.23155737704918 1.72226574254576 2.54299420175694e-09 5.34452614735917e-07 GO:0008094 ATP-dependent activity, acting on DNA 60/2506 210/18639 0.285714285714286 2.1250712575533 5.7382105153706e-09 1.03369763712605e-06 GO:0140713 histone chaperone activity 50/2506 164/18639 0.304878048780488 2.26760652482822 1.02687574229449e-08 1.61861288879168e-06 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 85/2506 349/18639 0.243553008595989 1.81148624390289 2.18214720211248e-08 3.05743069095982e-06 GO:0140097 catalytic activity, acting on DNA 82/2506 336/18639 0.244047619047619 1.81516503249344 3.50015213971784e-08 4.4136918481842e-06 GO:0140098 catalytic activity, acting on RNA 91/2506 387/18639 0.235142118863049 1.74892815382617 4.21359765372329e-08 4.83031512849552e-06 GO:0140674 ATP-dependent histone chaperone activity 46/2506 152/18639 0.302631578947368 2.25089784517159 5.04807208400646e-08 5.30468241494346e-06 GO:0061775 cohesin loader activity 46/2506 153/18639 0.300653594771242 2.23618609454955 6.28810553046175e-08 6.0994623645479e-06 GO:0140597 protein carrier chaperone 53/2506 188/18639 0.281914893617021 2.09681233125605 7.08247824055045e-08 6.37928932952437e-06 GO:0000510 H3-H4 histone complex chaperone activity 45/2506 151/18639 0.298013245033113 2.2165478348652 1.16054228633594e-07 8.13024346149787e-06 GO:0140584 chromatin extrusion motor activity 45/2506 151/18639 0.298013245033113 2.2165478348652 1.16054228633594e-07 8.13024346149787e-06 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 45/2506 151/18639 0.298013245033113 2.2165478348652 1.16054228633594e-07 8.13024346149787e-06 GO:0140849 ATP-dependent H2AZ histone chaperone activity 45/2506 151/18639 0.298013245033113 2.2165478348652 1.16054228633594e-07 8.13024346149787e-06 GO:0015616 DNA translocase activity 45/2506 152/18639 0.296052631578947 2.20196528332003 1.43631872098163e-07 9.53262056398858e-06 GO:0140030 modification-dependent protein binding 49/2506 173/18639 0.283236994219653 2.10664578422191 1.86031578150566e-07 1.17292910023932e-05 GO:0070063 RNA polymerase binding 24/2506 59/18639 0.406779661016949 3.02552518024538 2.0191556072571e-07 1.21245486702438e-05 GO:0004386 helicase activity 45/2506 155/18639 0.290322580645161 2.15934660041706 2.67904923055936e-07 1.53558230897061e-05 GO:0043175 RNA polymerase core enzyme binding 19/2506 42/18639 0.452380952380952 3.36469615779273 5.21383506761976e-07 2.85854174794284e-05 GO:0003689 DNA clamp loader activity 45/2506 160/18639 0.28125 2.09186701915403 7.19128449317774e-07 3.77842072745714e-05 GO:0031267 small GTPase binding 68/2506 283/18639 0.240282685512367 1.78716240034518 9.19705507678307e-07 4.63899458072938e-05 GO:0004842 ubiquitin-protein transferase activity 97/2506 449/18639 0.216035634743875 1.60681891300522 1.05438013669835e-06 5.11374366298701e-05 GO:0019787 ubiquitin-like protein transferase activity 102/2506 479/18639 0.21294363256785 1.58382137567125 1.1294189766068e-06 5.27480492407844e-05 GO:0051020 GTPase binding 73/2506 315/18639 0.231746031746032 1.72366890890434 1.59212874615373e-06 7.17026553178521e-05 GO:0016755 aminoacyltransferase activity 104/2506 496/18639 0.209677419354839 1.55952810030121 1.87784853039982e-06 8.16540343735922e-05 GO:0023026 MHC class II protein complex binding 14/2506 27/18639 0.518518518518518 3.85661080074488 2.17944251522137e-06 9.16092337231384e-05 GO:0003712 transcription coregulator activity 103/2506 495/18639 0.208080808080808 1.54765290575346 3.00994724890792e-06 0.000122436886479771 GO:0000993 RNA polymerase II complex binding 16/2506 36/18639 0.444444444444444 3.30566640063847 5.50033241667844e-06 0.000216747474294735 GO:0016922 nuclear receptor binding 38/2506 137/18639 0.277372262773723 2.06302538142036 7.286269529876e-06 0.000278423814459807 GO:0023023 MHC protein complex binding 16/2506 37/18639 0.432432432432432 3.21632406548608 8.48436381076051e-06 0.000314670081334383 GO:0003727 single-stranded RNA binding 28/2506 89/18639 0.314606741573034 2.33996610382274 8.80168174485383e-06 0.000317112019436019 GO:0035925 mRNA 3'-UTR AU-rich region binding 14/2506 30/18639 0.466666666666667 3.47094972067039 1.06316270866217e-05 0.000372402271006386 GO:0003724 RNA helicase activity 25/2506 77/18639 0.324675324675325 2.41485370176511 1.42562697336199e-05 0.000485869084705262 GO:0001098 basal transcription machinery binding 21/2506 60/18639 0.35 2.60321229050279 1.88908808534405e-05 0.000610805147594576 GO:0001099 basal RNA polymerase II transcription machinery binding 21/2506 60/18639 0.35 2.60321229050279 1.88908808534405e-05 0.000610805147594576 GO:0004197 cysteine-type endopeptidase activity 27/2506 88/18639 0.306818181818182 2.28203674816803 2.10592740901929e-05 0.000663893615693332 GO:0008186 ATP-dependent activity, acting on RNA 25/2506 79/18639 0.316455696202532 2.35371816501157 2.34178374584552e-05 0.000720241293539316 GO:0042393 histone binding 57/2506 247/18639 0.230769230769231 1.71640370802382 2.4138800339213e-05 0.000724738743517799 GO:0001618 virus receptor activity 25/2506 81/18639 0.308641975308642 2.29560166711005 3.75965236018935e-05 0.00110253991306948 GO:0140272 exogenous protein binding 25/2506 82/18639 0.304878048780488 2.26760652482822 4.72507492231643e-05 0.00135416351750932 GO:1990841 promoter-specific chromatin binding 22/2506 68/18639 0.323529411764706 2.40633068870006 4.86924356404972e-05 0.00136447025205927 GO:0038024 cargo receptor activity 21/2506 65/18639 0.323076923076923 2.40296519123335 7.34300856483985e-05 0.00201294213049197 GO:0016887 ATP hydrolysis activity 84/2506 417/18639 0.201438848920863 1.49825167798722 7.9485890178571e-05 0.00213258952159953 GO:0003725 double-stranded RNA binding 23/2506 75/18639 0.306666666666667 2.28090981644054 8.46575897881904e-05 0.00222402543172725 GO:0030331 nuclear estrogen receptor binding 15/2506 40/18639 0.375 2.78915602553871 0.000118393229082232 0.00304681350760601 GO:0042605 peptide antigen binding 16/2506 45/18639 0.355555555555556 2.64453312051077 0.000147548807082635 0.00372118091462406 GO:0140463 chromatin-protein adaptor activity 18/2506 54/18639 0.333333333333333 2.47924980047885 0.000150741870181848 0.00372716663331982 GO:0002039 p53 binding 21/2506 69/18639 0.304347826086957 2.26366286130678 0.000190923634023688 0.00462989812507444 GO:0031491 nucleosome binding 22/2506 74/18639 0.297297297297297 2.21122279502168 0.000197998531409184 0.00470865070852197 GO:0046332 SMAD binding 23/2506 79/18639 0.291139240506329 2.16542071181064 0.000202296523189012 0.00470865070852197 GO:0019838 growth factor binding 34/2506 136/18639 0.25 1.85943735035914 0.000205373345732521 0.00470865070852197 GO:0035198 miRNA binding 15/2506 42/18639 0.357142857142857 2.65633907194163 0.000223180909707246 0.00502555584180066 GO:0043130 ubiquitin binding 27/2506 100/18639 0.27 2.00819233838787 0.000237195975576584 0.00524744079301882 GO:0061133 endopeptidase activator activity 10/2506 22/18639 0.454545454545455 3.38079518247116 0.000261393921049553 0.00568306438695665 GO:0004674 protein serine/threonine kinase activity 84/2506 433/18639 0.193995381062356 1.44288902937799 0.000293343905862686 0.0062228055379292 GO:0019208 phosphatase regulator activity 30/2506 117/18639 0.256410256410256 1.90711523113758 0.000296089081899882 0.0062228055379292 GO:0016504 peptidase activator activity 18/2506 57/18639 0.315789473684211 2.3487629688747 0.000324014121009011 0.0066980624031535 GO:0034452 dynactin binding 7/2506 12/18639 0.583333333333333 4.33868715083799 0.00033544529391195 0.00674796283283781 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 39/2506 167/18639 0.233532934131737 1.73695944105405 0.000337130577691342 0.00674796283283781 GO:0008173 RNA methyltransferase activity 20/2506 67/18639 0.298507462686567 2.22022370192136 0.000357947442674996 0.00705268320645578 GO:0061980 regulatory RNA binding 18/2506 58/18639 0.310344827586207 2.30826705561824 0.000411461493097852 0.00798235296609834 GO:0008135 translation factor activity, RNA binding 23/2506 83/18639 0.27710843373494 2.06106308714507 0.000445777082634192 0.00851704395760176 GO:0032182 ubiquitin-like protein binding 30/2506 120/18639 0.25 1.85943735035914 0.000471602147535867 0.00887597474690638 GO:0031072 heat shock protein binding 32/2506 131/18639 0.244274809160305 1.81685481561809 0.000483371483151173 0.00896369765078867 GO:0001221 transcription coregulator binding 29/2506 115/18639 0.252173913043478 1.87560637079704 0.000498799886810815 0.00905958888130941 GO:0061659 ubiquitin-like protein ligase activity 73/2506 372/18639 0.196236559139785 1.4595583502819 0.000502911357408135 0.00905958888130941 GO:0019209 kinase activator activity 35/2506 148/18639 0.236486486486486 1.7589272233127 0.000517526822235524 0.00908275997467683 GO:0031593 polyubiquitin modification-dependent protein binding 18/2506 59/18639 0.305084745762712 2.26914388518403 0.000518603265802325 0.00908275997467683 GO:0180051 translation factor activity 23/2506 84/18639 0.273809523809524 2.03652662182191 0.000536887206180623 0.00927417489032555 GO:0003684 damaged DNA binding 21/2506 74/18639 0.283783783783784 2.11071266797524 0.000549479802327237 0.00936343284776549 GO:0019903 protein phosphatase binding 34/2506 144/18639 0.236111111111111 1.75613527533919 0.000636010341004725 0.0105723590954463 GO:0140852 histone ubiquitin ligase activity 7/2506 13/18639 0.538461538461538 4.00494198538891 0.00064242370415932 0.0105723590954463 GO:0004679 AMP-activated protein kinase activity 52/2506 248/18639 0.209677419354839 1.55952810030121 0.00065586979752138 0.0105723590954463 GO:0035091 phosphatidylinositol binding 58/2506 284/18639 0.204225352112676 1.51897699043423 0.000665313724850264 0.0105723590954463 GO:0019902 phosphatase binding 42/2506 190/18639 0.221052631578947 1.64413407821229 0.00069151451887328 0.0105723590954463 GO:0030695 GTPase regulator activity 91/2506 489/18639 0.186094069529652 1.38412105425506 0.000706073055493149 0.0105723590954463 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 51/2506 243/18639 0.209876543209877 1.56100913363483 0.000718281518977183 0.0105723590954463 GO:0060589 nucleoside-triphosphatase regulator activity 91/2506 490/18639 0.185714285714286 1.38129631740965 0.000755131696609458 0.0105723590954463 GO:0019888 protein phosphatase regulator activity 27/2506 107/18639 0.252336448598131 1.87681526952137 0.000757694242309228 0.0105723590954463 GO:0140311 protein sequestering activity 12/2506 33/18639 0.363636363636364 2.70463614597693 0.000778169232928438 0.0105723590954463 GO:0003713 transcription coactivator activity 53/2506 256/18639 0.20703125 1.53984655576616 0.000798409598557517 0.0105723590954463 GO:1990226 histone methyltransferase binding 8/2506 17/18639 0.470588235294118 3.50011736538191 0.0008273538290024 0.0105723590954463 GO:0019207 kinase regulator activity 58/2506 287/18639 0.202090592334495 1.50309918217185 0.000869680907711706 0.0105723590954463 GO:0004676 3-phosphoinositide-dependent protein kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0004711 ribosomal protein S6 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0035175 histone H3S10 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0035979 histone H2AXS139 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0044022 histone H3S28 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0044023 histone H4S1 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0044024 histone H2AS1 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0044025 histone H2BS14 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0072354 histone H3T3 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0072371 histone H2AS121 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0072518 Rho-dependent protein serine/threonine kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0140823 histone H2BS36 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0140855 histone H3S57 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0140995 histone H2A kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0140997 histone H4 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0140998 histone H2B kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:1990244 histone H2AT120 kinase activity 51/2506 245/18639 0.208163265306122 1.54826620193169 0.000871947141892476 0.0105723590954463 GO:0003714 transcription corepressor activity 44/2506 204/18639 0.215686274509804 1.60422045913337 0.000898241288881846 0.0107184986219521 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 10/2506 25/18639 0.4 2.97509976057462 0.000900999884160918 0.0107184986219521 GO:0004677 DNA-dependent protein kinase activity 51/2506 246/18639 0.207317073170732 1.54197243688319 0.000959193926205663 0.0111994772309754 GO:0140857 histone H3T45 kinase activity 51/2506 246/18639 0.207317073170732 1.54197243688319 0.000959193926205663 0.0111994772309754 GO:0048156 tau protein binding 14/2506 43/18639 0.325581395348837 2.42159282837469 0.00104151700199452 0.0119747466179323 GO:0035402 histone H3T11 kinase activity 51/2506 247/18639 0.206477732793522 1.535729633495 0.00105408158175296 0.0119747466179323 GO:0035403 histone H3T6 kinase activity 51/2506 247/18639 0.206477732793522 1.535729633495 0.00105408158175296 0.0119747466179323 GO:0140693 molecular condensate scaffold activity 15/2506 48/18639 0.3125 2.32429668794892 0.00112537735509589 0.012566167216737 GO:0005545 1-phosphatidylinositol binding 7/2506 14/18639 0.5 3.71887470071828 0.00113603732173515 0.012566167216737 GO:0030983 mismatched DNA binding 7/2506 14/18639 0.5 3.71887470071828 0.00113603732173515 0.012566167216737 GO:0008187 poly-pyrimidine tract binding 11/2506 30/18639 0.366666666666667 2.72717478052674 0.00118354160301213 0.0129777909686809 GO:0019887 protein kinase regulator activity 52/2506 255/18639 0.203921568627451 1.51671752499883 0.0012674015985625 0.0137232222376523 GO:0061630 ubiquitin protein ligase activity 68/2506 353/18639 0.192634560906516 1.43276759007843 0.00127328866122547 0.0137232222376523 GO:0050321 tau-protein kinase activity 9/2506 22/18639 0.409090909090909 3.04271566422404 0.00134679546378497 0.0143924498290919 GO:0008234 cysteine-type peptidase activity 40/2506 187/18639 0.213903743315508 1.59096243880996 0.0017604827697419 0.0186551997701222 GO:0008266 poly(U) RNA binding 10/2506 27/18639 0.37037037037037 2.75472200053206 0.00180331821680257 0.0189498689282337 GO:0005158 insulin receptor binding 9/2506 23/18639 0.391304347826087 2.910423678823 0.00195096698067834 0.0201440993778058 GO:0070577 lysine-acetylated histone binding 9/2506 23/18639 0.391304347826087 2.910423678823 0.00195096698067834 0.0201440993778058 GO:0016779 nucleotidyltransferase activity 31/2506 136/18639 0.227941176470588 1.69536934885686 0.00196488836119755 0.0201440993778058 GO:0031369 translation initiation factor binding 11/2506 32/18639 0.34375 2.55672635674381 0.00216426838203179 0.0216598605535086 GO:0051059 NF-kappaB binding 11/2506 32/18639 0.34375 2.55672635674381 0.00216426838203179 0.0216598605535086 GO:0070717 poly-purine tract binding 11/2506 32/18639 0.34375 2.55672635674381 0.00216426838203179 0.0216598605535086 GO:0003743 translation initiation factor activity 15/2506 51/18639 0.294117647058824 2.18757335336369 0.0022180305994437 0.0220231227236103 GO:0005178 integrin binding 35/2506 161/18639 0.217391304347826 1.61690204379055 0.00247987027821237 0.0244305970377015 GO:0000340 RNA 7-methylguanosine cap binding 6/2506 12/18639 0.5 3.71887470071828 0.00262268003298305 0.0254399963199356 GO:0035497 cAMP response element binding 6/2506 12/18639 0.5 3.71887470071828 0.00262268003298305 0.0254399963199356 GO:1990518 single-stranded 3'-5' DNA helicase activity 14/2506 47/18639 0.297872340425532 2.2154998217045 0.00269838797417032 0.0259745590490746 GO:0140033 acetylation-dependent protein binding 9/2506 24/18639 0.375 2.78915602553871 0.0027531039798851 0.0263004857472357 GO:0030295 protein kinase activator activity 31/2506 139/18639 0.223021582733813 1.65877864348585 0.00281328864937264 0.0266733608034504 GO:0008168 methyltransferase activity 42/2506 204/18639 0.205882352941176 1.53130134735458 0.00292527465496018 0.0275281443276476 GO:0000339 RNA cap binding 8/2506 20/18639 0.4 2.97509976057462 0.00295145126270156 0.0275687410538272 GO:1990782 protein tyrosine kinase binding 27/2506 117/18639 0.230769230769231 1.71640370802382 0.00308361375140885 0.0285016937060794 GO:0140223 general transcription initiation factor activity 18/2506 68/18639 0.264705882352941 1.96881601802732 0.00310818226275155 0.0285016937060794 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 12/2506 38/18639 0.315789473684211 2.3487629688747 0.00311913856577237 0.0285016937060794 GO:0043138 3'-5' DNA helicase activity 14/2506 48/18639 0.291666666666667 2.16934357541899 0.00334609822908332 0.030175646046691 GO:0016251 RNA polymerase II general transcription initiation factor activity 15/2506 53/18639 0.283018867924528 2.10502341550091 0.00335019067925197 0.030175646046691 GO:0106310 protein serine kinase activity 67/2506 361/18639 0.185595567867036 1.38041332381232 0.00354749253779847 0.0317261566678289 GO:0042277 peptide binding 49/2506 249/18639 0.196787148594378 1.46365349666824 0.00365007803162967 0.0322864765815038 GO:0016407 acetyltransferase activity 23/2506 96/18639 0.239583333333333 1.78196079409417 0.00367579335931589 0.0322864765815038 GO:0008080 N-acetyltransferase activity 18/2506 69/18639 0.260869565217391 1.94028245254867 0.00368695688163089 0.0322864765815038 GO:0008175 tRNA methyltransferase activity 11/2506 34/18639 0.323529411764706 2.40633068870006 0.00371835113418131 0.0323368329669147 GO:0030169 low-density lipoprotein particle binding 7/2506 17/18639 0.411764705882353 3.06260269470917 0.00445834401609862 0.0385066561938381 GO:0016741 transferase activity, transferring one-carbon groups 43/2506 215/18639 0.2 1.48754988028731 0.00457753431340085 0.0392671480897855 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 16/2506 60/18639 0.266666666666667 1.98339984038308 0.00476060250389657 0.0404075923380566 GO:0140566 histone reader activity 11/2506 35/18639 0.314285714285714 2.33757838330863 0.00477456880124539 0.0404075923380566 GO:0140313 molecular sequestering activity 15/2506 55/18639 0.272727272727273 2.0284771094827 0.00491754203721321 0.0413401367261724 GO:0004532 RNA exonuclease activity 12/2506 40/18639 0.3 2.23132482043097 0.00498111317638672 0.041597243148501 GO:0051539 4 iron, 4 sulfur cluster binding 13/2506 45/18639 0.288888888888889 2.148683160415 0.00505228589900577 0.0417106584617906 GO:0035173 histone kinase activity 66/2506 360/18639 0.183333333333333 1.36358739026337 0.00506084912343693 0.0417106584617906 GO:0005484 SNAP receptor activity 11/2506 36/18639 0.305555555555556 2.27264565043895 0.00605496304754882 0.0495799246945394 GO:0099122 RNA polymerase II C-terminal domain binding 5/2506 10/18639 0.5 3.71887470071828 0.00612519788783953 0.0498314486230042 GO:0035591 signaling adaptor activity 28/2506 129/18639 0.217054263565891 1.61439521891646 0.00646797443364068 0.0522827933385955 GO:0005044 scavenger receptor activity 9/2506 27/18639 0.333333333333333 2.47924980047885 0.00678053413596116 0.0544602136652677 GO:0043539 protein serine/threonine kinase activator activity 18/2506 73/18639 0.246575342465753 1.83396560583367 0.0069609555696043 0.0555554745143735 GO:0002020 protease binding 29/2506 136/18639 0.213235294117647 1.58599068118868 0.00731197061829145 0.0570623061206834 GO:0030515 snoRNA binding 10/2506 32/18639 0.3125 2.32429668794892 0.00733076414873173 0.0570623061206834 GO:0071813 lipoprotein particle binding 10/2506 32/18639 0.3125 2.32429668794892 0.00733076414873173 0.0570623061206834 GO:0071814 protein-lipid complex binding 10/2506 32/18639 0.3125 2.32429668794892 0.00733076414873173 0.0570623061206834 GO:0061749 forked DNA-dependent helicase activity 13/2506 47/18639 0.276595744680851 2.0572498344399 0.00752880476492144 0.0582443117089935 GO:0005096 GTPase activator activity 51/2506 271/18639 0.188191881918819 1.39972405709692 0.00762140597811091 0.0586011764536455 GO:0004518 nuclease activity 41/2506 209/18639 0.196172248803828 1.45908002611913 0.00775752418725944 0.059240594047965 GO:0141003 histone H2AX kinase activity 64/2506 354/18639 0.180790960451977 1.34467785788683 0.00779852387943076 0.059240594047965 GO:0017116 single-stranded DNA helicase activity 15/2506 58/18639 0.258620689655172 1.92355587968187 0.00833246346976471 0.0629175834453491 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 44/2506 229/18639 0.192139737991266 1.42908722123672 0.00870281044368976 0.0653228807707904 GO:1990380 K48-linked deubiquitinase activity 7/2506 19/18639 0.368421052631579 2.74022346368715 0.00905700418174804 0.0669759242342195 GO:0009378 four-way junction helicase activity 13/2506 48/18639 0.270833333333333 2.01439046288907 0.00908238147823277 0.0669759242342195 GO:0036121 double-stranded DNA helicase activity 13/2506 48/18639 0.270833333333333 2.01439046288907 0.00908238147823277 0.0669759242342195 GO:0044183 protein folding chaperone 18/2506 75/18639 0.24 1.78505985634477 0.00931578234091313 0.0682976833249503 GO:0140996 histone H3 kinase activity 64/2506 357/18639 0.179271708683473 1.33337804395501 0.00937335916872729 0.0683225775246538 GO:0004540 RNA nuclease activity 26/2506 121/18639 0.214876033057851 1.59819408625909 0.00966720878195507 0.0700594843335939 GO:0030971 receptor tyrosine kinase binding 19/2506 81/18639 0.234567901234568 1.74465726700364 0.00989265022106176 0.0711039610228169 GO:0015929 hexosaminidase activity 6/2506 15/18639 0.4 2.97509976057462 0.00992410558288325 0.0711039610228169 GO:0048407 platelet-derived growth factor binding 5/2506 11/18639 0.454545454545455 3.38079518247116 0.00999697724149957 0.0712214028335082 GO:0017069 snRNA binding 14/2506 54/18639 0.259259259259259 1.92830540037244 0.0103728570706377 0.0730735908719227 GO:0051287 NAD binding 14/2506 54/18639 0.259259259259259 1.92830540037244 0.0103728570706377 0.0730735908719227 GO:0035035 histone acetyltransferase binding 8/2506 24/18639 0.333333333333333 2.47924980047885 0.0105166212856585 0.0736747746734185 GO:0015631 tubulin binding 68/2506 385/18639 0.176623376623377 1.31368041376022 0.0106025699572572 0.0738665232933775 GO:0051213 dioxygenase activity 21/2506 93/18639 0.225806451612903 1.67949180032438 0.0108008212414237 0.0748342614584354 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 15/2506 60/18639 0.25 1.85943735035914 0.0115025059906535 0.079260437454722 GO:0015095 magnesium ion transmembrane transporter activity 7/2506 20/18639 0.35 2.60321229050279 0.0123446095996961 0.0846008299196566 GO:0000149 SNARE binding 23/2506 106/18639 0.216981132075472 1.61385128521737 0.012784950961157 0.0871449900649672 GO:0140662 ATP-dependent protein folding chaperone 11/2506 40/18639 0.275 2.04538108539505 0.0140443462290652 0.0945792302983306 GO:0005521 lamin binding 6/2506 16/18639 0.375 2.78915602553871 0.0141006306868249 0.0945792302983306 GO:0030275 LRR domain binding 6/2506 16/18639 0.375 2.78915602553871 0.0141006306868249 0.0945792302983306 GO:0000175 3'-5'-RNA exonuclease activity 10/2506 35/18639 0.285714285714286 2.1250712575533 0.0143180201466897 0.0955292243649508 GO:0000287 magnesium ion binding 43/2506 230/18639 0.18695652173913 1.39053575765988 0.0149258046660999 0.0985415690259266 GO:0005085 guanyl-nucleotide exchange factor activity 43/2506 230/18639 0.18695652173913 1.39053575765988 0.0149258046660999 0.0985415690259266 GO:0003995 acyl-CoA dehydrogenase activity 5/2506 12/18639 0.416666666666667 3.09906225059856 0.0152643323904399 0.0987093494581783 GO:0017166 vinculin binding 5/2506 12/18639 0.416666666666667 3.09906225059856 0.0152643323904399 0.0987093494581783 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 5/2506 12/18639 0.416666666666667 3.09906225059856 0.0152643323904399 0.0987093494581783 GO:1990247 N6-methyladenosine-containing RNA reader activity 5/2506 12/18639 0.416666666666667 3.09906225059856 0.0152643323904399 0.0987093494581783 GO:0035613 RNA stem-loop binding 7/2506 21/18639 0.333333333333333 2.47924980047885 0.0164108245519586 0.105045937868121 GO:0140312 cargo adaptor activity 7/2506 21/18639 0.333333333333333 2.47924980047885 0.0164108245519586 0.105045937868121 GO:0035064 methylated histone binding 17/2506 74/18639 0.22972972972973 1.70867215978948 0.0173653254396782 0.110233306259034 GO:0050681 nuclear androgen receptor binding 8/2506 26/18639 0.307692307692308 2.28853827736509 0.0174834744264924 0.110233306259034 GO:0070412 R-SMAD binding 8/2506 26/18639 0.307692307692308 2.28853827736509 0.0174834744264924 0.110233306259034 GO:0003697 single-stranded DNA binding 25/2506 121/18639 0.206611570247934 1.53672508294144 0.0177875722470385 0.11159267961948 GO:0004659 prenyltransferase activity 6/2506 17/18639 0.352941176470588 2.62508802403643 0.0193600597799483 0.119671742071151 GO:0005092 GDP-dissociation inhibitor activity 6/2506 17/18639 0.352941176470588 2.62508802403643 0.0193600597799483 0.119671742071151 GO:0048038 quinone binding 6/2506 17/18639 0.352941176470588 2.62508802403643 0.0193600597799483 0.119671742071151 GO:0048487 beta-tubulin binding 11/2506 42/18639 0.261904761904762 1.94798198609053 0.0202167821507675 0.123754185884067 GO:0051879 Hsp90 protein binding 11/2506 42/18639 0.261904761904762 1.94798198609053 0.0202167821507675 0.123754185884067 GO:0034212 protein N-acetyltransferase activity 13/2506 53/18639 0.245283018867925 1.82435362676746 0.0209165900306794 0.127419420428438 GO:0004175 endopeptidase activity 69/2506 405/18639 0.17037037037037 1.26717212024475 0.0217412167533282 0.129645542023278 GO:0001671 ATPase activator activity 8/2506 27/18639 0.296296296296296 2.20377760042564 0.0219899756014529 0.129645542023278 GO:0005385 zinc ion transmembrane transporter activity 8/2506 27/18639 0.296296296296296 2.20377760042564 0.0219899756014529 0.129645542023278 GO:1901981 phosphatidylinositol phosphate binding 35/2506 185/18639 0.189189189189189 1.40714177865016 0.0220772124151731 0.129645542023278 GO:0004535 poly(A)-specific ribonuclease activity 5/2506 13/18639 0.384615384615385 2.86067284670637 0.0221045135091235 0.129645542023278 GO:0008035 high-density lipoprotein particle binding 5/2506 13/18639 0.384615384615385 2.86067284670637 0.0221045135091235 0.129645542023278 GO:0043560 insulin receptor substrate binding 5/2506 13/18639 0.384615384615385 2.86067284670637 0.0221045135091235 0.129645542023278 GO:0097157 pre-mRNA intronic binding 5/2506 13/18639 0.384615384615385 2.86067284670637 0.0221045135091235 0.129645542023278 GO:0051536 iron-sulfur cluster binding 17/2506 76/18639 0.223684210526316 1.66370710295291 0.0223217273910389 0.129712895115668 GO:0140034 methylation-dependent protein binding 17/2506 76/18639 0.223684210526316 1.66370710295291 0.0223217273910389 0.129712895115668 GO:0016410 N-acyltransferase activity 20/2506 94/18639 0.212765957446809 1.58249987264608 0.0236134411404575 0.136589675587692 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 13/2506 54/18639 0.240740740740741 1.79056930034584 0.0242597248716682 0.139687274261067 GO:0051540 metal cluster binding 17/2506 77/18639 0.220779220779221 1.64210051720028 0.0251702454206105 0.144271270342681 GO:0030228 lipoprotein particle receptor activity 6/2506 18/18639 0.333333333333333 2.47924980047885 0.0258106413916114 0.146609093670369 GO:0035615 clathrin adaptor activity 6/2506 18/18639 0.333333333333333 2.47924980047885 0.0258106413916114 0.146609093670369 GO:0016763 pentosyltransferase activity 12/2506 49/18639 0.244897959183673 1.8214896493314 0.0262075016724274 0.147534194682728 GO:0060590 ATPase regulator activity 12/2506 49/18639 0.244897959183673 1.8214896493314 0.0262075016724274 0.147534194682728 GO:0071889 14-3-3 protein binding 9/2506 33/18639 0.272727272727273 2.0284771094827 0.0265299109693719 0.148027512090168 GO:0140416 transcription regulator inhibitor activity 9/2506 33/18639 0.272727272727273 2.0284771094827 0.0265299109693719 0.148027512090168 GO:0004721 phosphoprotein phosphatase activity 33/2506 175/18639 0.188571428571429 1.40254702998518 0.0267559341290328 0.148630982100046 GO:0042171 lysophosphatidic acid acyltransferase activity 7/2506 23/18639 0.304347826086957 2.26366286130678 0.0272065783907873 0.149440678214877 GO:0071617 lysophospholipid acyltransferase activity 7/2506 23/18639 0.304347826086957 2.26366286130678 0.0272065783907873 0.149440678214877 GO:0046966 nuclear thyroid hormone receptor binding 8/2506 28/18639 0.285714285714286 2.1250712575533 0.0272572212445849 0.149440678214877 GO:0001046 core promoter sequence-specific DNA binding 11/2506 44/18639 0.25 1.85943735035914 0.0281859148520531 0.153863370685883 GO:0004527 exonuclease activity 18/2506 84/18639 0.214285714285714 1.59380344316498 0.0287119673306697 0.15605944312058 GO:0008174 mRNA methyltransferase activity 5/2506 14/18639 0.357142857142857 2.65633907194163 0.0306581062588284 0.165213128172575 GO:0034236 protein kinase A catalytic subunit binding 5/2506 14/18639 0.357142857142857 2.65633907194163 0.0306581062588284 0.165213128172575 GO:0004519 endonuclease activity 25/2506 127/18639 0.196850393700787 1.46412389792058 0.0309224376946637 0.165628241676594 GO:0043021 ribonucleoprotein complex binding 33/2506 177/18639 0.186440677966102 1.3866990409458 0.0309978311147314 0.165628241676594 GO:0015035 protein-disulfide reductase activity 9/2506 34/18639 0.264705882352941 1.96881601802732 0.031907803803926 0.169771057370256 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 19/2506 91/18639 0.208791208791209 1.55293668821203 0.0321632318169947 0.170411072778279 GO:0046915 transition metal ion transmembrane transporter activity 11/2506 45/18639 0.244444444444444 1.81811652035116 0.0329194867965192 0.173437759842714 GO:0106222 lncRNA binding 8/2506 29/18639 0.275862068965517 2.05179293832732 0.0333375772381934 0.173437759842714 GO:0042625 ATPase-coupled ion transmembrane transporter activity 7/2506 24/18639 0.291666666666667 2.16934357541899 0.0340789136693696 0.173437759842714 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 7/2506 24/18639 0.291666666666667 2.16934357541899 0.0340789136693696 0.173437759842714 GO:0046961 proton-transporting ATPase activity, rotational mechanism 7/2506 24/18639 0.291666666666667 2.16934357541899 0.0340789136693696 0.173437759842714 GO:0048027 mRNA 5'-UTR binding 7/2506 24/18639 0.291666666666667 2.16934357541899 0.0340789136693696 0.173437759842714 GO:0050431 transforming growth factor beta binding 7/2506 24/18639 0.291666666666667 2.16934357541899 0.0340789136693696 0.173437759842714 GO:0060229 lipase activator activity 7/2506 24/18639 0.291666666666667 2.16934357541899 0.0340789136693696 0.173437759842714 GO:0140612 DNA damage sensor activity 7/2506 24/18639 0.291666666666667 2.16934357541899 0.0340789136693696 0.173437759842714 GO:0030145 manganese ion binding 15/2506 68/18639 0.220588235294118 1.64068001502277 0.0343147791965667 0.173437759842714 GO:0008190 eukaryotic initiation factor 4E binding 4/2506 10/18639 0.4 2.97509976057462 0.034953086608596 0.173437759842714 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/2506 10/18639 0.4 2.97509976057462 0.034953086608596 0.173437759842714 GO:0031720 haptoglobin binding 4/2506 10/18639 0.4 2.97509976057462 0.034953086608596 0.173437759842714 GO:0032356 oxidized DNA binding 4/2506 10/18639 0.4 2.97509976057462 0.034953086608596 0.173437759842714 GO:0032395 MHC class II receptor activity 4/2506 10/18639 0.4 2.97509976057462 0.034953086608596 0.173437759842714 GO:0003678 DNA helicase activity 16/2506 74/18639 0.216216216216216 1.60816203274304 0.0349562134724004 0.173437759842714 GO:0004177 aminopeptidase activity 10/2506 40/18639 0.25 1.85943735035914 0.035485283139905 0.173437759842714 GO:0032451 demethylase activity 10/2506 40/18639 0.25 1.85943735035914 0.035485283139905 0.173437759842714 GO:0061791 GTPase motor activity 10/2506 40/18639 0.25 1.85943735035914 0.035485283139905 0.173437759842714 GO:1990606 membrane scission GTPase motor activity 10/2506 40/18639 0.25 1.85943735035914 0.035485283139905 0.173437759842714 GO:0008017 microtubule binding 48/2506 276/18639 0.173913043478261 1.29352163503244 0.0356757504997025 0.173695449344112 GO:0005154 epidermal growth factor receptor binding 9/2506 35/18639 0.257142857142857 1.91256413179797 0.0379965750698925 0.184283389088978 GO:0030276 clathrin binding 11/2506 46/18639 0.239130434782609 1.77859224816961 0.0381888668776946 0.184366619868489 GO:0016853 isomerase activity 33/2506 180/18639 0.183333333333333 1.36358739026337 0.0383061494096305 0.184366619868489 GO:0019003 GDP binding 16/2506 75/18639 0.213333333333333 1.58671987230646 0.0390868003723134 0.187408575169153 GO:0003924 GTPase activity 56/2506 331/18639 0.169184290030211 1.25835035190467 0.0399855798279841 0.190220883111482 GO:0001965 G-protein alpha-subunit binding 8/2506 30/18639 0.266666666666667 1.98339984038308 0.0402767452741995 0.190220883111482 GO:0032452 histone demethylase activity 8/2506 30/18639 0.266666666666667 1.98339984038308 0.0402767452741995 0.190220883111482 GO:0051721 protein phosphatase 2A binding 8/2506 30/18639 0.266666666666667 1.98339984038308 0.0402767452741995 0.190220883111482 GO:0005525 GTP binding 63/2506 378/18639 0.166666666666667 1.23962490023943 0.0405248334163288 0.190678413947726 GO:0005041 low-density lipoprotein particle receptor activity 5/2506 15/18639 0.333333333333333 2.47924980047885 0.0410251065968011 0.191602442290986 GO:0120283 protein serine/threonine kinase binding 5/2506 15/18639 0.333333333333333 2.47924980047885 0.0410251065968011 0.191602442290986 GO:0061650 ubiquitin-like protein conjugating enzyme activity 10/2506 41/18639 0.24390243902439 1.81408521986257 0.0414735240455947 0.192981969821015 GO:0008408 3'-5' exonuclease activity 13/2506 58/18639 0.224137931034483 1.66708176239095 0.0416268434681703 0.192983270637363 GO:0019211 phosphatase activator activity 7/2506 25/18639 0.28 2.08256983240223 0.0420119107398063 0.193346786287941 GO:0042974 nuclear retinoic acid receptor binding 7/2506 25/18639 0.28 2.08256983240223 0.0420119107398063 0.193346786287941 GO:0016004 phospholipase activator activity 6/2506 20/18639 0.3 2.23132482043097 0.0426281520781665 0.194761231052782 GO:0043024 ribosomal small subunit binding 6/2506 20/18639 0.3 2.23132482043097 0.0426281520781665 0.194761231052782 GO:0061733 protein-lysine-acetyltransferase activity 11/2506 47/18639 0.234042553191489 1.74074985991068 0.0440184474623098 0.199666410971125 GO:0140938 histone H3 methyltransferase activity 11/2506 47/18639 0.234042553191489 1.74074985991068 0.0440184474623098 0.199666410971125 GO:0016409 palmitoyltransferase activity 9/2506 36/18639 0.25 1.85943735035914 0.0448300604161984 0.201895379231522 GO:0044390 ubiquitin-like protein conjugating enzyme binding 9/2506 36/18639 0.25 1.85943735035914 0.0448300604161984 0.201895379231522 GO:0140296 general transcription initiation factor binding 12/2506 53/18639 0.226415094339623 1.68401873240073 0.0458305852811276 0.205666790176164 GO:0051015 actin filament binding 37/2506 209/18639 0.177033492822967 1.31673075527824 0.0471995433800261 0.210367802005672 GO:0008276 protein methyltransferase activity 19/2506 95/18639 0.2 1.48754988028731 0.0475363256473257 0.210367802005672 GO:0140457 protein demethylase activity 8/2506 31/18639 0.258064516129032 1.91941920037072 0.048112850961356 0.210367802005672 GO:0004402 histone acetyltransferase activity 10/2506 42/18639 0.238095238095238 1.77089271462775 0.0481162558877282 0.210367802005672 GO:0019107 myristoyltransferase activity 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0032050 clathrin heavy chain binding 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0032404 mismatch repair complex binding 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0032794 GTPase activating protein binding 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0034713 type I transforming growth factor beta receptor binding 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0042608 T cell receptor binding 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0043522 leucine zipper domain binding 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0048185 activin binding 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0140031 phosphorylation-dependent protein binding 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0140537 transcription regulator activator activity 4/2506 11/18639 0.363636363636364 2.70463614597693 0.0492137205326512 0.210367802005672 GO:0046982 protein heterodimerization activity 61/2506 369/18639 0.165311653116531 1.22954664901797 0.0495632835900016 0.211146285834433 GO:0005160 transforming growth factor beta receptor binding 7/2506 26/18639 0.269230769230769 2.00247099269446 0.0510487030657641 0.214574715219762 GO:0008143 poly(A) binding 7/2506 26/18639 0.269230769230769 2.00247099269446 0.0510487030657641 0.214574715219762 GO:0050750 low-density lipoprotein particle receptor binding 7/2506 26/18639 0.269230769230769 2.00247099269446 0.0510487030657641 0.214574715219762 GO:0070006 metalloaminopeptidase activity 7/2506 26/18639 0.269230769230769 2.00247099269446 0.0510487030657641 0.214574715219762 GO:0042826 histone deacetylase binding 24/2506 127/18639 0.188976377952756 1.40555894200376 0.051536961518424 0.215907337125358 GO:0051082 unfolded protein binding 23/2506 121/18639 0.190082644628099 1.41378707630612 0.0526982957320681 0.217461427840218 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 13/2506 60/18639 0.216666666666667 1.61151237031125 0.0529759064509666 0.217461427840218 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 6/2506 21/18639 0.285714285714286 2.1250712575533 0.0531150830886496 0.217461427840218 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 6/2506 21/18639 0.285714285714286 2.1250712575533 0.0531150830886496 0.217461427840218 GO:0051010 microtubule plus-end binding 6/2506 21/18639 0.285714285714286 2.1250712575533 0.0531150830886496 0.217461427840218 GO:0070182 DNA polymerase binding 6/2506 21/18639 0.285714285714286 2.1250712575533 0.0531150830886496 0.217461427840218 GO:0072542 protein phosphatase activator activity 6/2506 21/18639 0.285714285714286 2.1250712575533 0.0531150830886496 0.217461427840218 GO:0017124 SH3 domain binding 22/2506 115/18639 0.191304347826087 1.42287379853569 0.0538320406418753 0.219683505661504 GO:0031490 chromatin DNA binding 24/2506 128/18639 0.1875 1.39457801276935 0.0556563371030119 0.226395616409348 GO:0022884 macromolecule transmembrane transporter activity 8/2506 32/18639 0.25 1.85943735035914 0.0568757252206864 0.229872722766941 GO:0140142 nucleocytoplasmic carrier activity 8/2506 32/18639 0.25 1.85943735035914 0.0568757252206864 0.229872722766941 GO:0001222 transcription corepressor binding 11/2506 49/18639 0.224489795918367 1.66969884522045 0.0574415678012157 0.23141794567838 GO:0019001 guanyl nucleotide binding 65/2506 400/18639 0.1625 1.20863427773344 0.0588085293317255 0.235420811070812 GO:0032561 guanyl ribonucleotide binding 65/2506 400/18639 0.1625 1.20863427773344 0.0588085293317255 0.235420811070812 GO:0042054 histone methyltransferase activity 14/2506 67/18639 0.208955223880597 1.55415659134495 0.0596083386309547 0.237867452574791 GO:0042162 telomeric DNA binding 9/2506 38/18639 0.236842105263158 1.76157222665603 0.060838938390463 0.241251261982308 GO:0043531 ADP binding 9/2506 38/18639 0.236842105263158 1.76157222665603 0.060838938390463 0.241251261982308 GO:0016791 phosphatase activity 46/2506 273/18639 0.168498168498169 1.25324715189041 0.0611996039895239 0.241920691632569 GO:0008170 N-methyltransferase activity 19/2506 98/18639 0.193877551020408 1.44201263905403 0.0620836613565482 0.244648428033148 GO:0001223 transcription coactivator binding 10/2506 44/18639 0.227272727272727 1.69039759123558 0.0634506465457016 0.246205282641113 GO:0043014 alpha-tubulin binding 10/2506 44/18639 0.227272727272727 1.69039759123558 0.0634506465457016 0.246205282641113 GO:0050660 flavin adenine dinucleotide binding 17/2506 86/18639 0.197674418604651 1.47025278865606 0.0642061993037626 0.246205282641113 GO:0016798 hydrolase activity, acting on glycosyl bonds 24/2506 130/18639 0.184615384615385 1.37312296641906 0.0645870478398939 0.246205282641113 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 6/2506 22/18639 0.272727272727273 2.0284771094827 0.0650309556131096 0.246205282641113 GO:0046972 histone H4K16 acetyltransferase activity 6/2506 22/18639 0.272727272727273 2.0284771094827 0.0650309556131096 0.246205282641113 GO:0070034 telomerase RNA binding 6/2506 22/18639 0.272727272727273 2.0284771094827 0.0650309556131096 0.246205282641113 GO:0140035 ubiquitin-like protein reader activity 6/2506 22/18639 0.272727272727273 2.0284771094827 0.0650309556131096 0.246205282641113 GO:0140517 protein-RNA adaptor activity 6/2506 22/18639 0.272727272727273 2.0284771094827 0.0650309556131096 0.246205282641113 GO:0000995 RNA polymerase III general transcription initiation factor activity 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:0005049 nuclear export signal receptor activity 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:0005078 MAP-kinase scaffold activity 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:0005095 GTPase inhibitor activity 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:0016273 arginine N-methyltransferase activity 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:0016274 protein-arginine N-methyltransferase activity 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:0016423 tRNA (guanine) methyltransferase activity 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:0035197 siRNA binding 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:0042301 phosphate ion binding 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:1990459 transferrin receptor binding 4/2506 12/18639 0.333333333333333 2.47924980047885 0.0661884146037568 0.246205282641113 GO:0046965 nuclear retinoid X receptor binding 5/2506 17/18639 0.294117647058824 2.18757335336369 0.0673899401367622 0.249204441385505 GO:0051787 misfolded protein binding 5/2506 17/18639 0.294117647058824 2.18757335336369 0.0673899401367622 0.249204441385505 GO:0042578 phosphoric ester hydrolase activity 59/2506 363/18639 0.162534435261708 1.2088903985806 0.0686622951143701 0.253167117366142 GO:0019955 cytokine binding 26/2506 144/18639 0.180555555555556 1.34292697525938 0.070173517481098 0.257984855812433 GO:0141052 histone H3 demethylase activity 7/2506 28/18639 0.25 1.85943735035914 0.0725399364895024 0.265909476492042 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 8/2506 34/18639 0.235294117647059 1.75005868269095 0.0772567186971627 0.282378905151079 GO:0044013 histone H2B acetyltransferase activity 6/2506 23/18639 0.260869565217391 1.94028245254867 0.0783807358092232 0.28565927125847 GO:0015036 disulfide oxidoreductase activity 9/2506 40/18639 0.225 1.67349361532322 0.0800889245515672 0.29104361342803 GO:0019783 ubiquitin-like protein peptidase activity 23/2506 127/18639 0.181102362204724 1.34699398608693 0.0822489554056142 0.298034289558849 GO:0003746 translation elongation factor activity 5/2506 18/18639 0.277777777777778 2.06604150039904 0.0833819781156665 0.298706764403481 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 5/2506 18/18639 0.277777777777778 2.06604150039904 0.0833819781156665 0.298706764403481 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 17/2506 89/18639 0.191011235955056 1.42069370589238 0.083382062704223 0.298706764403481 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 17/2506 89/18639 0.191011235955056 1.42069370589238 0.083382062704223 0.298706764403481 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/2506 13/18639 0.307692307692308 2.28853827736509 0.0857812595347049 0.30332971806727 GO:0019104 DNA N-glycosylase activity 4/2506 13/18639 0.307692307692308 2.28853827736509 0.0857812595347049 0.30332971806727 GO:0046975 histone H3K36 methyltransferase activity 4/2506 13/18639 0.307692307692308 2.28853827736509 0.0857812595347049 0.30332971806727 GO:0051011 microtubule minus-end binding 4/2506 13/18639 0.307692307692308 2.28853827736509 0.0857812595347049 0.30332971806727 GO:0008238 exopeptidase activity 19/2506 102/18639 0.186274509803922 1.385463123797 0.0858752651467213 0.30332971806727 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 23/2506 128/18639 0.1796875 1.33647059557063 0.0880740051290418 0.310227152144474 GO:0010485 histone H4 acetyltransferase activity 8/2506 35/18639 0.228571428571429 1.70005700604264 0.0888893538459836 0.311359653332737 GO:0061631 ubiquitin conjugating enzyme activity 8/2506 35/18639 0.228571428571429 1.70005700604264 0.0888893538459836 0.311359653332737 GO:0140793 histone H2AXY142 phosphatase activity 17/2506 90/18639 0.188888888888889 1.40490822027135 0.0905204251447496 0.316194615256314 GO:0036002 pre-mRNA binding 12/2506 59/18639 0.203389830508475 1.51276259012269 0.0910997480385763 0.317339177559792 GO:0016860 intramolecular oxidoreductase activity 11/2506 53/18639 0.207547169811321 1.543683838034 0.0917413796206884 0.318693883475725 GO:0043998 histone H2A acetyltransferase activity 6/2506 24/18639 0.25 1.85943735035914 0.0931480098558412 0.320927979312065 GO:0050699 WW domain binding 6/2506 24/18639 0.25 1.85943735035914 0.0931480098558412 0.320927979312065 GO:0070840 dynein complex binding 6/2506 24/18639 0.25 1.85943735035914 0.0931480098558412 0.320927979312065 GO:0009055 electron transfer activity 21/2506 116/18639 0.181034482758621 1.34648911577731 0.0937678583847911 0.322183295431122 GO:0043995 histone H4K5 acetyltransferase activity 7/2506 30/18639 0.233333333333333 1.7354748603352 0.0986289224379836 0.336138030254858 GO:0043996 histone H4K8 acetyltransferase activity 7/2506 30/18639 0.233333333333333 1.7354748603352 0.0986289224379836 0.336138030254858 GO:0043997 histone H4K12 acetyltransferase activity 7/2506 30/18639 0.233333333333333 1.7354748603352 0.0986289224379836 0.336138030254858 GO:0005543 phospholipid binding 77/2506 497/18639 0.154929577464789 1.15232737205355 0.10012833299044 0.339335037123564 GO:0098531 ligand-modulated transcription factor activity 12/2506 60/18639 0.2 1.48754988028731 0.100630708435479 0.339335037123564 GO:0003756 protein disulfide isomerase activity 5/2506 19/18639 0.263157894736842 1.95730247406225 0.101181581251753 0.339335037123564 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 5/2506 19/18639 0.263157894736842 1.95730247406225 0.101181581251753 0.339335037123564 GO:0042800 histone H3K4 methyltransferase activity 5/2506 19/18639 0.263157894736842 1.95730247406225 0.101181581251753 0.339335037123564 GO:0140036 ubiquitin-modified protein reader activity 5/2506 19/18639 0.263157894736842 1.95730247406225 0.101181581251753 0.339335037123564 GO:0003925 G protein activity 11/2506 54/18639 0.203703703703704 1.51509710029263 0.101909393690915 0.34086935131099 GO:0019894 kinesin binding 9/2506 42/18639 0.214285714285714 1.59380344316498 0.10263130141373 0.34207808283507 GO:0004725 protein tyrosine phosphatase activity 18/2506 98/18639 0.183673469387755 1.36611723699855 0.102813317521405 0.34207808283507 GO:0003779 actin binding 69/2506 443/18639 0.155756207674944 1.15847564040434 0.105375210482926 0.349679316892026 GO:0004521 RNA endonuclease activity 14/2506 73/18639 0.191780821917808 1.42641769342619 0.10599101440279 0.350799656592961 GO:0005344 oxygen carrier activity 4/2506 14/18639 0.285714285714286 2.1250712575533 0.107830520845056 0.352264991672578 GO:0008474 palmitoyl-(protein) hydrolase activity 4/2506 14/18639 0.285714285714286 2.1250712575533 0.107830520845056 0.352264991672578 GO:0016530 metallochaperone activity 4/2506 14/18639 0.285714285714286 2.1250712575533 0.107830520845056 0.352264991672578 GO:0071933 Arp2/3 complex binding 4/2506 14/18639 0.285714285714286 2.1250712575533 0.107830520845056 0.352264991672578 GO:0098599 palmitoyl hydrolase activity 4/2506 14/18639 0.285714285714286 2.1250712575533 0.107830520845056 0.352264991672578 GO:0003707 nuclear steroid receptor activity 6/2506 25/18639 0.24 1.78505985634477 0.109296251681957 0.353391213771662 GO:0017025 TBP-class protein binding 6/2506 25/18639 0.24 1.78505985634477 0.109296251681957 0.353391213771662 GO:0019706 protein-cysteine S-palmitoyltransferase activity 6/2506 25/18639 0.24 1.78505985634477 0.109296251681957 0.353391213771662 GO:0019707 protein-cysteine S-acyltransferase activity 6/2506 25/18639 0.24 1.78505985634477 0.109296251681957 0.353391213771662 GO:0043022 ribosome binding 20/2506 112/18639 0.178571428571429 1.32816953597081 0.111153025445123 0.358475614031457 GO:0016411 acylglycerol O-acyltransferase activity 7/2506 31/18639 0.225806451612903 1.67949180032438 0.113362776618667 0.363741631847681 GO:0070325 lipoprotein particle receptor binding 7/2506 31/18639 0.225806451612903 1.67949180032438 0.113362776618667 0.363741631847681 GO:0030742 GTP-dependent protein binding 5/2506 20/18639 0.25 1.85943735035914 0.120699390976281 0.385321346888837 GO:0140664 ATP-dependent DNA damage sensor activity 5/2506 20/18639 0.25 1.85943735035914 0.120699390976281 0.385321346888837 GO:0052742 phosphatidylinositol kinase activity 6/2506 26/18639 0.230769230769231 1.71640370802382 0.126770516266815 0.403680861142561 GO:0016279 protein-lysine N-methyltransferase activity 13/2506 69/18639 0.188405797101449 1.40131510461848 0.128966391705162 0.409638841159216 GO:0004843 cysteine-type deubiquitinase activity 19/2506 108/18639 0.175925925925926 1.30849295025273 0.131466641016508 0.413418376744859 GO:0004559 alpha-mannosidase activity 4/2506 15/18639 0.266666666666667 1.98339984038308 0.132123398753512 0.413418376744859 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/2506 15/18639 0.266666666666667 1.98339984038308 0.132123398753512 0.413418376744859 GO:0031386 protein tag activity 4/2506 15/18639 0.266666666666667 1.98339984038308 0.132123398753512 0.413418376744859 GO:0042809 nuclear vitamin D receptor binding 4/2506 15/18639 0.266666666666667 1.98339984038308 0.132123398753512 0.413418376744859 GO:0141047 molecular tag activity 4/2506 15/18639 0.266666666666667 1.98339984038308 0.132123398753512 0.413418376744859 GO:0101005 deubiquitinase activity 20/2506 115/18639 0.173913043478261 1.29352163503244 0.135157615159909 0.421865724546151 GO:0016278 lysine N-methyltransferase activity 13/2506 70/18639 0.185714285714286 1.38129631740965 0.139980430660539 0.425633540820252 GO:0097110 scaffold protein binding 13/2506 70/18639 0.185714285714286 1.38129631740965 0.139980430660539 0.425633540820252 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0005031 tumor necrosis factor receptor activity 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0005131 growth hormone receptor binding 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0008239 dipeptidyl-peptidase activity 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0045322 unmethylated CpG binding 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0051880 G-quadruplex DNA binding 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0098505 G-rich strand telomeric DNA binding 3/2506 10/18639 0.3 2.23132482043097 0.141090261746919 0.425633540820252 GO:0008009 chemokine activity 9/2506 45/18639 0.2 1.48754988028731 0.142471136041283 0.428773514434504 GO:0044325 transmembrane transporter binding 23/2506 136/18639 0.169117647058824 1.25785467818412 0.144303193433098 0.432224054439755 GO:0140789 histone phosphatase activity 23/2506 136/18639 0.169117647058824 1.25785467818412 0.144303193433098 0.432224054439755 GO:0000217 DNA secondary structure binding 8/2506 39/18639 0.205128205128205 1.52569218491006 0.144779381978461 0.432622750414313 GO:0008320 protein transmembrane transporter activity 6/2506 27/18639 0.222222222222222 1.65283320031923 0.145499447292113 0.433746579279798 GO:0008237 metallopeptidase activity 30/2506 184/18639 0.16304347826087 1.21267653284292 0.150700499037555 0.448191814354614 GO:0004860 protein kinase inhibitor activity 15/2506 84/18639 0.178571428571429 1.32816953597081 0.151950863380918 0.449788823294219 GO:0051117 ATPase binding 15/2506 84/18639 0.178571428571429 1.32816953597081 0.151950863380918 0.449788823294219 GO:0030159 signaling receptor complex adaptor activity 10/2506 52/18639 0.192307692307692 1.43033642335318 0.153169903061187 0.452335474848141 GO:0019843 rRNA binding 12/2506 65/18639 0.184615384615385 1.37312296641906 0.15673577322946 0.452421349389703 GO:0004707 MAP kinase activity 4/2506 16/18639 0.25 1.85943735035914 0.158410030092116 0.452421349389703 GO:0005024 transforming growth factor beta receptor activity 4/2506 16/18639 0.25 1.85943735035914 0.158410030092116 0.452421349389703 GO:0005149 interleukin-1 receptor binding 4/2506 16/18639 0.25 1.85943735035914 0.158410030092116 0.452421349389703 GO:0005159 insulin-like growth factor receptor binding 4/2506 16/18639 0.25 1.85943735035914 0.158410030092116 0.452421349389703 GO:0015923 mannosidase activity 4/2506 16/18639 0.25 1.85943735035914 0.158410030092116 0.452421349389703 GO:0017070 U6 snRNA binding 4/2506 16/18639 0.25 1.85943735035914 0.158410030092116 0.452421349389703 GO:0034450 ubiquitin-ubiquitin ligase activity 4/2506 16/18639 0.25 1.85943735035914 0.158410030092116 0.452421349389703 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 8/2506 40/18639 0.2 1.48754988028731 0.160951996335185 0.452421349389703 GO:0022853 active monoatomic ion transmembrane transporter activity 20/2506 118/18639 0.169491525423729 1.26063549176891 0.161936602717305 0.452421349389703 GO:0004879 nuclear receptor activity 11/2506 59/18639 0.186440677966102 1.3866990409458 0.162075797807894 0.452421349389703 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/2506 59/18639 0.186440677966102 1.3866990409458 0.162075797807894 0.452421349389703 GO:0005518 collagen binding 13/2506 72/18639 0.180555555555556 1.34292697525938 0.163478021365816 0.452421349389703 GO:0016831 carboxy-lyase activity 7/2506 34/18639 0.205882352941176 1.53130134735458 0.163861431359752 0.452421349389703 GO:0008093 cytoskeletal anchor activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0008649 rRNA methyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0032931 histone H3K56 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0034062 5'-3' RNA polymerase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0043992 histone H3K9 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0043993 histone H3K18 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0043994 histone H3K23 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0043999 histone H2AK5 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0044012 histone H2AK9 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0044014 histone H2BK5 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0044015 histone H2BK12 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0044016 histone H3K4 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0044017 histone H3K27 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0044018 histone H3K36 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0097747 RNA polymerase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0140908 histone H3K122 acetyltransferase activity 5/2506 22/18639 0.227272727272727 1.69039759123558 0.164404349420007 0.452421349389703 GO:0036408 histone H3K14 acetyltransferase activity 6/2506 28/18639 0.214285714285714 1.59380344316498 0.165397495692825 0.452421349389703 GO:0051019 mitogen-activated protein kinase binding 6/2506 28/18639 0.214285714285714 1.59380344316498 0.165397495692825 0.452421349389703 GO:0097718 disordered domain specific binding 6/2506 28/18639 0.214285714285714 1.59380344316498 0.165397495692825 0.452421349389703 GO:0051018 protein kinase A binding 10/2506 53/18639 0.188679245283019 1.40334894366727 0.167455606186884 0.457059565804459 GO:0008235 metalloexopeptidase activity 12/2506 66/18639 0.181818181818182 1.35231807298846 0.169570070425133 0.460209853408653 GO:0140101 catalytic activity, acting on a tRNA 23/2506 139/18639 0.165467625899281 1.2307067354895 0.169751899951702 0.460209853408653 GO:0005504 fatty acid binding 9/2506 47/18639 0.191489361702128 1.42424988538147 0.172787143972239 0.460209853408653 GO:0043495 protein-membrane adaptor activity 9/2506 47/18639 0.191489361702128 1.42424988538147 0.172787143972239 0.460209853408653 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0001851 complement component C3b binding 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0005114 type II transforming growth factor beta receptor binding 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0008526 phosphatidylinositol transfer activity 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0015173 aromatic amino acid transmembrane transporter activity 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0019206 nucleoside kinase activity 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0019864 IgG binding 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0034511 U3 snoRNA binding 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0045294 alpha-catenin binding 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0097493 structural molecule activity conferring elasticity 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0180030 inositol phosphate kinase activity 3/2506 11/18639 0.272727272727273 2.0284771094827 0.17554396470227 0.460209853408653 GO:0001530 lipopolysaccharide binding 8/2506 41/18639 0.195121951219512 1.45126817589006 0.177922297036109 0.463553753228376 GO:0016877 ligase activity, forming carbon-sulfur bonds 8/2506 41/18639 0.195121951219512 1.45126817589006 0.177922297036109 0.463553753228376 GO:0140318 protein transporter activity 8/2506 41/18639 0.195121951219512 1.45126817589006 0.177922297036109 0.463553753228376 GO:0004713 protein tyrosine kinase activity 23/2506 140/18639 0.164285714285714 1.22191597309315 0.17874038176859 0.464724992598333 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 10/2506 54/18639 0.185185185185185 1.37736100026603 0.18235247266324 0.471083853404479 GO:0034061 DNA polymerase activity 7/2506 35/18639 0.2 1.48754988028731 0.182604450738195 0.471083853404479 GO:0051087 protein-folding chaperone binding 22/2506 134/18639 0.164179104477612 1.22112303605675 0.185996187541438 0.471083853404479 GO:0004629 phospholipase C activity 6/2506 29/18639 0.206896551724138 1.53884470374549 0.186367256021449 0.471083853404479 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 6/2506 29/18639 0.206896551724138 1.53884470374549 0.186367256021449 0.471083853404479 GO:0010484 histone H3 acetyltransferase activity 6/2506 29/18639 0.206896551724138 1.53884470374549 0.186367256021449 0.471083853404479 GO:0016417 S-acyltransferase activity 6/2506 29/18639 0.206896551724138 1.53884470374549 0.186367256021449 0.471083853404479 GO:0097472 cyclin-dependent protein kinase activity 6/2506 29/18639 0.206896551724138 1.53884470374549 0.186367256021449 0.471083853404479 GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/2506 17/18639 0.235294117647059 1.75005868269095 0.18641621161684 0.471083853404479 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 4/2506 17/18639 0.235294117647059 1.75005868269095 0.18641621161684 0.471083853404479 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/2506 17/18639 0.235294117647059 1.75005868269095 0.18641621161684 0.471083853404479 GO:0031489 myosin V binding 4/2506 17/18639 0.235294117647059 1.75005868269095 0.18641621161684 0.471083853404479 GO:0036041 long-chain fatty acid binding 4/2506 17/18639 0.235294117647059 1.75005868269095 0.18641621161684 0.471083853404479 GO:0070403 NAD+ binding 4/2506 17/18639 0.235294117647059 1.75005868269095 0.18641621161684 0.471083853404479 GO:0003887 DNA-directed DNA polymerase activity 5/2506 23/18639 0.217391304347826 1.61690204379055 0.188299797645224 0.472803411924558 GO:0008171 O-methyltransferase activity 5/2506 23/18639 0.217391304347826 1.61690204379055 0.188299797645224 0.472803411924558 GO:0140102 catalytic activity, acting on a rRNA 5/2506 23/18639 0.217391304347826 1.61690204379055 0.188299797645224 0.472803411924558 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/2506 48/18639 0.1875 1.39457801276935 0.188971387478174 0.472803411924558 GO:0032266 phosphatidylinositol-3-phosphate binding 9/2506 48/18639 0.1875 1.39457801276935 0.188971387478174 0.472803411924558 GO:0005548 phospholipid transporter activity 12/2506 68/18639 0.176470588235294 1.31254401201822 0.196713042181536 0.491198309288945 GO:0008374 O-acyltransferase activity 10/2506 55/18639 0.181818181818182 1.35231807298846 0.197827900249236 0.493005893704123 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 20/2506 122/18639 0.163934426229508 1.21930318056337 0.201727109008021 0.501731527532769 GO:0045505 dynein intermediate chain binding 7/2506 36/18639 0.194444444444444 1.44622905027933 0.20218676423426 0.501884861612997 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 14/2506 82/18639 0.170731707317073 1.2698596539038 0.20677972522805 0.504197166441529 GO:0001968 fibronectin binding 6/2506 30/18639 0.2 1.48754988028731 0.208301839417316 0.504197166441529 GO:0031624 ubiquitin conjugating enzyme binding 6/2506 30/18639 0.2 1.48754988028731 0.208301839417316 0.504197166441529 GO:0070566 adenylyltransferase activity 6/2506 30/18639 0.2 1.48754988028731 0.208301839417316 0.504197166441529 GO:0004875 complement receptor activity 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0005165 neurotrophin receptor binding 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0016208 AMP binding 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0035259 nuclear glucocorticoid receptor binding 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0036009 protein-glutamine N-methyltransferase activity 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0043047 single-stranded telomeric DNA binding 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:1990817 poly(A) RNA polymerase activity 3/2506 12/18639 0.25 1.85943735035914 0.211995814735107 0.504197166441529 GO:0015078 proton transmembrane transporter activity 29/2506 185/18639 0.156756756756757 1.1659174737387 0.213099146890158 0.504197166441529 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/2506 24/18639 0.208333333333333 1.54953112529928 0.213339741800325 0.504197166441529 GO:0004622 lysophospholipase activity 5/2506 24/18639 0.208333333333333 1.54953112529928 0.213339741800325 0.504197166441529 GO:0019212 phosphatase inhibitor activity 10/2506 56/18639 0.178571428571429 1.32816953597081 0.21384597721258 0.504197166441529 GO:0030170 pyridoxal phosphate binding 10/2506 56/18639 0.178571428571429 1.32816953597081 0.21384597721258 0.504197166441529 GO:0008375 acetylglucosaminyltransferase activity 8/2506 43/18639 0.186046511627907 1.38376733049982 0.214040941495766 0.504197166441529 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/2506 43/18639 0.186046511627907 1.38376733049982 0.214040941495766 0.504197166441529 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/2506 18/18639 0.222222222222222 1.65283320031923 0.215854564045747 0.504197166441529 GO:0008409 5'-3' exonuclease activity 4/2506 18/18639 0.222222222222222 1.65283320031923 0.215854564045747 0.504197166441529 GO:0017128 phospholipid scramblase activity 4/2506 18/18639 0.222222222222222 1.65283320031923 0.215854564045747 0.504197166441529 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 4/2506 18/18639 0.222222222222222 1.65283320031923 0.215854564045747 0.504197166441529 GO:0050811 GABA receptor binding 4/2506 18/18639 0.222222222222222 1.65283320031923 0.215854564045747 0.504197166441529 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/2506 18/18639 0.222222222222222 1.65283320031923 0.215854564045747 0.504197166441529 GO:0017022 myosin binding 13/2506 76/18639 0.171052631578947 1.27224660814046 0.215913140268379 0.504197166441529 GO:0043394 proteoglycan binding 7/2506 37/18639 0.189189189189189 1.40714177865016 0.222528875283487 0.518685603941733 GO:0019210 kinase inhibitor activity 15/2506 90/18639 0.166666666666667 1.23962490023943 0.223528359348082 0.520053987339356 GO:0004601 peroxidase activity 10/2506 57/18639 0.175438596491228 1.3048683160415 0.230367869253144 0.533996108691572 GO:0070279 vitamin B6 binding 10/2506 57/18639 0.175438596491228 1.3048683160415 0.230367869253144 0.533996108691572 GO:0004536 DNA nuclease activity 11/2506 64/18639 0.171875 1.27836317837191 0.236111439947947 0.546305551879562 GO:0004709 MAP kinase kinase kinase activity 5/2506 25/18639 0.2 1.48754988028731 0.239350614329917 0.548765681218228 GO:0008139 nuclear localization sequence binding 5/2506 25/18639 0.2 1.48754988028731 0.239350614329917 0.548765681218228 GO:0008483 transaminase activity 5/2506 25/18639 0.2 1.48754988028731 0.239350614329917 0.548765681218228 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 5/2506 25/18639 0.2 1.48754988028731 0.239350614329917 0.548765681218228 GO:0120020 cholesterol transfer activity 5/2506 25/18639 0.2 1.48754988028731 0.239350614329917 0.548765681218228 GO:0140299 molecular sensor activity 12/2506 71/18639 0.169014084507042 1.2570844058766 0.240750677728156 0.549786962594049 GO:0005048 signal sequence binding 9/2506 51/18639 0.176470588235294 1.31254401201822 0.241104036728397 0.549786962594049 GO:0030544 Hsp70 protein binding 9/2506 51/18639 0.176470588235294 1.31254401201822 0.241104036728397 0.549786962594049 GO:0019199 transmembrane receptor protein kinase activity 13/2506 78/18639 0.166666666666667 1.23962490023943 0.244527035762217 0.554686981297124 GO:0008301 DNA binding, bending 4/2506 19/18639 0.210526315789474 1.5658419792498 0.246434026124145 0.554686981297124 GO:0046624 sphingolipid transporter activity 4/2506 19/18639 0.210526315789474 1.5658419792498 0.246434026124145 0.554686981297124 GO:0097001 ceramide binding 4/2506 19/18639 0.210526315789474 1.5658419792498 0.246434026124145 0.554686981297124 GO:0120227 acyl-CoA binding 4/2506 19/18639 0.210526315789474 1.5658419792498 0.246434026124145 0.554686981297124 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0005035 death receptor activity 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0009982 pseudouridine synthase activity 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0019855 calcium channel inhibitor activity 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0030955 potassium ion binding 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0035325 Toll-like receptor binding 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0035673 oligopeptide transmembrane transporter activity 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0140666 annealing activity 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/2506 13/18639 0.230769230769231 1.71640370802382 0.249860181295228 0.554686981297124 GO:0004857 enzyme inhibitor activity 61/2506 416/18639 0.146634615384615 1.0906315228068 0.250290953495689 0.554686981297124 GO:0140303 intramembrane lipid transporter activity 8/2506 45/18639 0.177777777777778 1.32226656025539 0.252658538797722 0.558951609515662 GO:0016757 glycosyltransferase activity 40/2506 267/18639 0.149812734082397 1.11426957324892 0.253610407419853 0.560074822690779 GO:0120015 sterol transfer activity 6/2506 32/18639 0.1875 1.39457801276935 0.254604459907197 0.561287104795411 GO:0005080 protein kinase C binding 9/2506 52/18639 0.173076923076923 1.28730278101786 0.25950885540293 0.571100639900689 GO:0051219 phosphoprotein binding 15/2506 93/18639 0.161290322580645 1.1996370002317 0.263895595262118 0.579657960059082 GO:0061134 peptidase regulator activity 34/2506 226/18639 0.150442477876106 1.11895344977364 0.265802979293931 0.579657960059082 GO:0004529 DNA exonuclease activity 5/2506 26/18639 0.192307692307692 1.43033642335318 0.266155399583036 0.579657960059082 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 5/2506 26/18639 0.192307692307692 1.43033642335318 0.266155399583036 0.579657960059082 GO:0030507 spectrin binding 5/2506 26/18639 0.192307692307692 1.43033642335318 0.266155399583036 0.579657960059082 GO:0120014 phospholipid transfer activity 5/2506 26/18639 0.192307692307692 1.43033642335318 0.266155399583036 0.579657960059082 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 8/2506 46/18639 0.173913043478261 1.29352163503244 0.272739452672233 0.591952581445242 GO:0030291 protein serine/threonine kinase inhibitor activity 8/2506 46/18639 0.173913043478261 1.29352163503244 0.272739452672233 0.591952581445242 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 4/2506 20/18639 0.2 1.48754988028731 0.277867684911111 0.598774968187539 GO:0042288 MHC class I protein binding 4/2506 20/18639 0.2 1.48754988028731 0.277867684911111 0.598774968187539 GO:0061608 nuclear import signal receptor activity 4/2506 20/18639 0.2 1.48754988028731 0.277867684911111 0.598774968187539 GO:0140939 histone H4 methyltransferase activity 4/2506 20/18639 0.2 1.48754988028731 0.277867684911111 0.598774968187539 GO:0004864 protein phosphatase inhibitor activity 9/2506 53/18639 0.169811320754717 1.26301404930055 0.278337929106212 0.598774968187539 GO:0030296 protein tyrosine kinase activator activity 6/2506 33/18639 0.181818181818182 1.35231807298846 0.278731884477466 0.598774968187539 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 11/2506 67/18639 0.164179104477612 1.22112303605675 0.285699701099142 0.608228085783072 GO:0016829 lyase activity 30/2506 200/18639 0.15 1.11566241021548 0.287290233378233 0.608228085783072 GO:0008191 metalloendopeptidase inhibitor activity 3/2506 14/18639 0.214285714285714 1.59380344316498 0.288595543236184 0.608228085783072 GO:0019763 immunoglobulin receptor activity 3/2506 14/18639 0.214285714285714 1.59380344316498 0.288595543236184 0.608228085783072 GO:0070742 C2H2 zinc finger domain binding 3/2506 14/18639 0.214285714285714 1.59380344316498 0.288595543236184 0.608228085783072 GO:0098847 sequence-specific single stranded DNA binding 3/2506 14/18639 0.214285714285714 1.59380344316498 0.288595543236184 0.608228085783072 GO:0033192 calmodulin-dependent protein phosphatase activity 13/2506 81/18639 0.160493827160494 1.19371286689722 0.289885074984636 0.608228085783072 GO:0140791 histone H2AXS140 phosphatase activity 13/2506 81/18639 0.160493827160494 1.19371286689722 0.289885074984636 0.608228085783072 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 13/2506 81/18639 0.160493827160494 1.19371286689722 0.289885074984636 0.608228085783072 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 13/2506 81/18639 0.160493827160494 1.19371286689722 0.289885074984636 0.608228085783072 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 13/2506 81/18639 0.160493827160494 1.19371286689722 0.289885074984636 0.608228085783072 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 13/2506 81/18639 0.160493827160494 1.19371286689722 0.289885074984636 0.608228085783072 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 13/2506 81/18639 0.160493827160494 1.19371286689722 0.289885074984636 0.608228085783072 GO:1990439 MAP kinase serine/threonine phosphatase activity 13/2506 81/18639 0.160493827160494 1.19371286689722 0.289885074984636 0.608228085783072 GO:0016651 oxidoreductase activity, acting on NAD(P)H 14/2506 88/18639 0.159090909090909 1.18327831386491 0.291207663969846 0.609988146621221 GO:0035255 ionotropic glutamate receptor binding 5/2506 27/18639 0.185185185185185 1.37736100026603 0.293577206921882 0.613931771025694 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 10/2506 61/18639 0.163934426229508 1.21930318056337 0.300637375805521 0.627655183593976 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 11/2506 68/18639 0.161764705882353 1.20316534435003 0.302872565100786 0.631276536515853 GO:0033549 MAP kinase phosphatase activity 13/2506 82/18639 0.158536585365854 1.17915539291067 0.305542604648921 0.635790799442722 GO:0004222 metalloendopeptidase activity 17/2506 110/18639 0.154545454545455 1.14947036204019 0.30668351505023 0.637113529618353 GO:0001727 lipid kinase activity 7/2506 41/18639 0.170731707317073 1.2698596539038 0.309764392611754 0.637450980782927 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7/2506 41/18639 0.170731707317073 1.2698596539038 0.309764392611754 0.637450980782927 GO:0042169 SH2 domain binding 7/2506 41/18639 0.170731707317073 1.2698596539038 0.309764392611754 0.637450980782927 GO:0001846 opsonin binding 4/2506 21/18639 0.19047619047619 1.4167141717022 0.309879025551098 0.637450980782927 GO:0010314 phosphatidylinositol-5-phosphate binding 4/2506 21/18639 0.19047619047619 1.4167141717022 0.309879025551098 0.637450980782927 GO:0019200 carbohydrate kinase activity 4/2506 21/18639 0.19047619047619 1.4167141717022 0.309879025551098 0.637450980782927 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 20/2506 132/18639 0.151515151515152 1.12693172749039 0.318063318823318 0.652719513523389 GO:1902936 phosphatidylinositol bisphosphate binding 17/2506 111/18639 0.153153153153153 1.13911477319299 0.32035857074837 0.652719513523389 GO:0005126 cytokine receptor binding 40/2506 275/18639 0.145454545454545 1.08185445839077 0.320396313334902 0.652719513523389 GO:0001540 amyloid-beta binding 13/2506 83/18639 0.156626506024096 1.16494870142982 0.321420209276531 0.652719513523389 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 13/2506 83/18639 0.156626506024096 1.16494870142982 0.321420209276531 0.652719513523389 GO:0046625 sphingolipid binding 5/2506 28/18639 0.178571428571429 1.32816953597081 0.321442361536895 0.652719513523389 GO:0046875 ephrin receptor binding 5/2506 28/18639 0.178571428571429 1.32816953597081 0.321442361536895 0.652719513523389 GO:0051959 dynein light intermediate chain binding 5/2506 28/18639 0.178571428571429 1.32816953597081 0.321442361536895 0.652719513523389 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/2506 15/18639 0.2 1.48754988028731 0.327713579356852 0.658036343262724 GO:0050700 CARD domain binding 3/2506 15/18639 0.2 1.48754988028731 0.327713579356852 0.658036343262724 GO:0050780 dopamine receptor binding 3/2506 15/18639 0.2 1.48754988028731 0.327713579356852 0.658036343262724 GO:0061578 K63-linked deubiquitinase activity 3/2506 15/18639 0.2 1.48754988028731 0.327713579356852 0.658036343262724 GO:0140776 protein-containing complex destabilizing activity 3/2506 15/18639 0.2 1.48754988028731 0.327713579356852 0.658036343262724 GO:0141050 histone H3K deacetylase activity 3/2506 15/18639 0.2 1.48754988028731 0.327713579356852 0.658036343262724 GO:0141051 histone H4K deacetylase activity 3/2506 15/18639 0.2 1.48754988028731 0.327713579356852 0.658036343262724 GO:0004520 DNA endonuclease activity 7/2506 42/18639 0.166666666666667 1.23962490023943 0.332589706050535 0.665707332269405 GO:0031492 nucleosomal DNA binding 7/2506 42/18639 0.166666666666667 1.23962490023943 0.332589706050535 0.665707332269405 GO:0017018 myosin phosphatase activity 13/2506 84/18639 0.154761904761905 1.15108026450804 0.33748766169317 0.674440477646732 GO:0004407 histone deacetylase activity 4/2506 22/18639 0.181818181818182 1.35231807298846 0.342206731358007 0.681710407965951 GO:0033558 protein lysine deacetylase activity 4/2506 22/18639 0.181818181818182 1.35231807298846 0.342206731358007 0.681710407965951 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 6/2506 36/18639 0.166666666666667 1.23962490023943 0.353556480973769 0.700997991364658 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 6/2506 36/18639 0.166666666666667 1.23962490023943 0.353556480973769 0.700997991364658 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 6/2506 36/18639 0.166666666666667 1.23962490023943 0.353556480973769 0.700997991364658 GO:0032813 tumor necrosis factor receptor superfamily binding 8/2506 50/18639 0.16 1.19003990422985 0.356574272442106 0.705871518916006 GO:0000062 fatty-acyl-CoA binding 3/2506 16/18639 0.1875 1.39457801276935 0.366783629187176 0.717076211480665 GO:0003688 DNA replication origin binding 3/2506 16/18639 0.1875 1.39457801276935 0.366783629187176 0.717076211480665 GO:0008296 3'-5'-DNA exonuclease activity 3/2506 16/18639 0.1875 1.39457801276935 0.366783629187176 0.717076211480665 GO:0031435 mitogen-activated protein kinase kinase kinase binding 3/2506 16/18639 0.1875 1.39457801276935 0.366783629187176 0.717076211480665 GO:0043023 ribosomal large subunit binding 3/2506 16/18639 0.1875 1.39457801276935 0.366783629187176 0.717076211480665 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/2506 16/18639 0.1875 1.39457801276935 0.366783629187176 0.717076211480665 GO:0055102 lipase inhibitor activity 3/2506 16/18639 0.1875 1.39457801276935 0.366783629187176 0.717076211480665 GO:0070411 I-SMAD binding 3/2506 16/18639 0.1875 1.39457801276935 0.366783629187176 0.717076211480665 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 13/2506 86/18639 0.151162790697674 1.12431095603111 0.370069936829241 0.72002983056842 GO:0016209 antioxidant activity 13/2506 86/18639 0.151162790697674 1.12431095603111 0.370069936829241 0.72002983056842 GO:0033293 monocarboxylic acid binding 12/2506 79/18639 0.151898734177215 1.12978471920555 0.371934773219056 0.72002983056842 GO:0000295 adenine nucleotide transmembrane transporter activity 4/2506 23/18639 0.173913043478261 1.29352163503244 0.374608191087013 0.72002983056842 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 4/2506 23/18639 0.173913043478261 1.29352163503244 0.374608191087013 0.72002983056842 GO:0016849 phosphorus-oxygen lyase activity 4/2506 23/18639 0.173913043478261 1.29352163503244 0.374608191087013 0.72002983056842 GO:0017134 fibroblast growth factor binding 4/2506 23/18639 0.173913043478261 1.29352163503244 0.374608191087013 0.72002983056842 GO:0140103 catalytic activity, acting on a glycoprotein 4/2506 23/18639 0.173913043478261 1.29352163503244 0.374608191087013 0.72002983056842 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 4/2506 23/18639 0.173913043478261 1.29352163503244 0.374608191087013 0.72002983056842 GO:0120013 lipid transfer activity 10/2506 65/18639 0.153846153846154 1.14426913868255 0.375378680811758 0.72002983056842 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 9/2506 58/18639 0.155172413793103 1.15413352780912 0.376856299952089 0.72002983056842 GO:0015215 nucleotide transmembrane transporter activity 5/2506 30/18639 0.166666666666667 1.23962490023943 0.377839242339672 0.72002983056842 GO:0016769 transferase activity, transferring nitrogenous groups 5/2506 30/18639 0.166666666666667 1.23962490023943 0.377839242339672 0.72002983056842 GO:0031210 phosphatidylcholine binding 5/2506 30/18639 0.166666666666667 1.23962490023943 0.377839242339672 0.72002983056842 GO:0005010 insulin-like growth factor receptor activity 8/2506 51/18639 0.156862745098039 1.16670578846064 0.378057106993494 0.72002983056842 GO:0005021 vascular endothelial growth factor receptor activity 8/2506 51/18639 0.156862745098039 1.16670578846064 0.378057106993494 0.72002983056842 GO:0016830 carbon-carbon lyase activity 8/2506 51/18639 0.156862745098039 1.16670578846064 0.378057106993494 0.72002983056842 GO:0003954 NADH dehydrogenase activity 7/2506 44/18639 0.159090909090909 1.18327831386491 0.378829998298332 0.72002983056842 GO:0015399 primary active transmembrane transporter activity 24/2506 166/18639 0.144578313253012 1.0753372628583 0.383911242452624 0.72002983056842 GO:0008081 phosphoric diester hydrolase activity 13/2506 87/18639 0.149425287356322 1.11138784159397 0.386523565743757 0.72002983056842 GO:0004620 phospholipase activity 16/2506 109/18639 0.146788990825688 1.09177972865124 0.393642989533246 0.72002983056842 GO:0045309 protein phosphorylated amino acid binding 9/2506 59/18639 0.152542372881356 1.13457194259202 0.397034430596186 0.72002983056842 GO:0000182 rDNA binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0004382 GDP phosphatase activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0005381 iron ion transmembrane transporter activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0005522 profilin binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0008140 cAMP response element binding protein binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0016427 tRNA (cytidine) methyltransferase activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0016783 sulfurtransferase activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0030957 Tat protein binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0035256 G protein-coupled glutamate receptor binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0050815 phosphoserine residue binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0051864 histone H3K36 demethylase activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0070513 death domain binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0097177 mitochondrial ribosome binding 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0140940 histone H2A methyltransferase activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0140999 histone H3K4 trimethyltransferase activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:1990259 histone H2AQ104 methyltransferase activity 2/2506 10/18639 0.2 1.48754988028731 0.39741535454054 0.72002983056842 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/2506 17/18639 0.176470588235294 1.31254401201822 0.405433790095105 0.722609622353277 GO:0008429 phosphatidylethanolamine binding 3/2506 17/18639 0.176470588235294 1.31254401201822 0.405433790095105 0.722609622353277 GO:0016805 dipeptidase activity 3/2506 17/18639 0.176470588235294 1.31254401201822 0.405433790095105 0.722609622353277 GO:0017110 nucleoside diphosphate phosphatase activity 3/2506 17/18639 0.176470588235294 1.31254401201822 0.405433790095105 0.722609622353277 GO:0019198 transmembrane receptor protein phosphatase activity 3/2506 17/18639 0.176470588235294 1.31254401201822 0.405433790095105 0.722609622353277 GO:0032977 membrane insertase activity 3/2506 17/18639 0.176470588235294 1.31254401201822 0.405433790095105 0.722609622353277 GO:1901567 fatty acid derivative binding 3/2506 17/18639 0.176470588235294 1.31254401201822 0.405433790095105 0.722609622353277 GO:0005164 tumor necrosis factor receptor binding 5/2506 31/18639 0.161290322580645 1.1996370002317 0.406060786157111 0.722609622353277 GO:0017147 Wnt-protein binding 5/2506 31/18639 0.161290322580645 1.1996370002317 0.406060786157111 0.722609622353277 GO:0070273 phosphatidylinositol-4-phosphate binding 5/2506 31/18639 0.161290322580645 1.1996370002317 0.406060786157111 0.722609622353277 GO:0016758 hexosyltransferase activity 28/2506 197/18639 0.142131979695431 1.05714204690469 0.406473876126676 0.722609622353277 GO:0005540 hyaluronic acid binding 4/2506 24/18639 0.166666666666667 1.23962490023943 0.406861880944351 0.722609622353277 GO:0015295 solute:proton symporter activity 4/2506 24/18639 0.166666666666667 1.23962490023943 0.406861880944351 0.722609622353277 GO:0070300 phosphatidic acid binding 4/2506 24/18639 0.166666666666667 1.23962490023943 0.406861880944351 0.722609622353277 GO:0140767 enzyme-substrate adaptor activity 20/2506 139/18639 0.143884892086331 1.07017976999087 0.408583352369782 0.724646423823199 GO:0048029 monosaccharide binding 11/2506 74/18639 0.148648648648649 1.10561139751084 0.409867075263325 0.725902221779568 GO:0004722 protein serine/threonine phosphatase activity 15/2506 103/18639 0.145631067961165 1.08316738855872 0.412006801512668 0.728668410529416 GO:0001217 DNA-binding transcription repressor activity 39/2506 278/18639 0.140287769784173 1.0434252757411 0.413327634998883 0.729224692348864 GO:0050840 extracellular matrix binding 10/2506 67/18639 0.149253731343284 1.11011185096068 0.413477918342139 0.729224692348864 GO:0004714 transmembrane receptor protein tyrosine kinase activity 9/2506 60/18639 0.15 1.11566241021548 0.417240605941585 0.734832966609411 GO:0061135 endopeptidase regulator activity 26/2506 184/18639 0.141304347826087 1.05098632846386 0.42444440740413 0.746477542171002 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 6/2506 39/18639 0.153846153846154 1.14426913868255 0.42959798855628 0.75208819223449 GO:0043425 bHLH transcription factor binding 5/2506 32/18639 0.15625 1.16214834397446 0.434108253981169 0.75208819223449 GO:0015026 coreceptor activity 9/2506 61/18639 0.147540983606557 1.09737286250703 0.437421934234365 0.75208819223449 GO:0000030 mannosyltransferase activity 4/2506 25/18639 0.16 1.19003990422985 0.43876878887091 0.75208819223449 GO:0001848 complement binding 4/2506 25/18639 0.16 1.19003990422985 0.43876878887091 0.75208819223449 GO:0140375 immune receptor activity 22/2506 156/18639 0.141025641025641 1.04891337712567 0.439684601024383 0.75208819223449 GO:0000400 four-way junction DNA binding 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0000900 mRNA regulatory element binding translation repressor activity 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0004706 JUN kinase kinase kinase activity 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0008308 voltage-gated monoatomic anion channel activity 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0008525 phosphatidylcholine transporter activity 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0017075 syntaxin-1 binding 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0034185 apolipoprotein binding 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0070064 proline-rich region binding 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:1901611 phosphatidylglycerol binding 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:1990381 ubiquitin-specific protease binding 3/2506 18/18639 0.166666666666667 1.23962490023943 0.443349635304977 0.75208819223449 GO:0000099 sulfur amino acid transmembrane transporter activity 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0002162 dystroglycan binding 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0004016 adenylate cyclase activity 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0004523 RNA-DNA hybrid ribonuclease activity 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0005536 D-glucose binding 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0008199 ferric iron binding 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0008432 JUN kinase binding 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0010854 adenylate cyclase regulator activity 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0015217 ADP transmembrane transporter activity 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0019215 intermediate filament binding 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0034056 estrogen response element binding 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0070990 snRNP binding 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/2506 11/18639 0.181818181818182 1.35231807298846 0.446720107837932 0.75208819223449 GO:0001784 phosphotyrosine residue binding 7/2506 47/18639 0.148936170212766 1.10774991085225 0.448393218219238 0.753898464232612 GO:0050997 quaternary ammonium group binding 6/2506 40/18639 0.15 1.11566241021548 0.454717380677178 0.763513471416673 GO:0019842 vitamin binding 21/2506 150/18639 0.14 1.04128491620112 0.456745931152899 0.765899759552932 GO:0001216 DNA-binding transcription activator activity 67/2506 491/18639 0.136456211812627 1.01492710773167 0.467922571063872 0.77576425049979 GO:0004435 phosphatidylinositol phospholipase C activity 4/2506 26/18639 0.153846153846154 1.14426913868255 0.470153041468705 0.77576425049979 GO:0015216 purine nucleotide transmembrane transporter activity 4/2506 26/18639 0.153846153846154 1.14426913868255 0.470153041468705 0.77576425049979 GO:0030247 polysaccharide binding 4/2506 26/18639 0.153846153846154 1.14426913868255 0.470153041468705 0.77576425049979 GO:0034237 protein kinase A regulatory subunit binding 4/2506 26/18639 0.153846153846154 1.14426913868255 0.470153041468705 0.77576425049979 GO:0043548 phosphatidylinositol 3-kinase binding 4/2506 26/18639 0.153846153846154 1.14426913868255 0.470153041468705 0.77576425049979 GO:0051139 metal cation:proton antiporter activity 4/2506 26/18639 0.153846153846154 1.14426913868255 0.470153041468705 0.77576425049979 GO:0097602 cullin family protein binding 4/2506 26/18639 0.153846153846154 1.14426913868255 0.470153041468705 0.77576425049979 GO:0042287 MHC protein binding 6/2506 41/18639 0.146341463414634 1.08845113191754 0.479566464345537 0.77576425049979 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/2506 19/18639 0.157894736842105 1.17438148443735 0.480271312026383 0.77576425049979 GO:0005520 insulin-like growth factor binding 3/2506 19/18639 0.157894736842105 1.17438148443735 0.480271312026383 0.77576425049979 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/2506 19/18639 0.157894736842105 1.17438148443735 0.480271312026383 0.77576425049979 GO:0031420 alkali metal ion binding 3/2506 19/18639 0.157894736842105 1.17438148443735 0.480271312026383 0.77576425049979 GO:0070003 threonine-type peptidase activity 3/2506 19/18639 0.157894736842105 1.17438148443735 0.480271312026383 0.77576425049979 GO:0016874 ligase activity 23/2506 167/18639 0.137724550898204 1.02436069600623 0.48479779673889 0.77576425049979 GO:0016298 lipase activity 18/2506 130/18639 0.138461538461538 1.02984222481429 0.485323854756589 0.77576425049979 GO:0008376 acetylgalactosaminyltransferase activity 5/2506 34/18639 0.147058823529412 1.09378667668185 0.48918283643513 0.77576425049979 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 5/2506 34/18639 0.147058823529412 1.09378667668185 0.48918283643513 0.77576425049979 GO:0019825 oxygen binding 5/2506 34/18639 0.147058823529412 1.09378667668185 0.48918283643513 0.77576425049979 GO:0030332 cyclin binding 5/2506 34/18639 0.147058823529412 1.09378667668185 0.48918283643513 0.77576425049979 GO:0052866 phosphatidylinositol phosphate phosphatase activity 5/2506 34/18639 0.147058823529412 1.09378667668185 0.48918283643513 0.77576425049979 GO:0003720 telomerase activity 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0005025 transforming growth factor beta receptor activity, type I 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0005026 transforming growth factor beta receptor activity, type II 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0005247 voltage-gated chloride channel activity 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0015132 prostaglandin transmembrane transporter activity 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0016361 activin receptor activity, type I 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0016362 activin receptor activity, type II 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0016801 hydrolase activity, acting on ether bonds 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0016803 ether hydrolase activity 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0016840 carbon-nitrogen lyase activity 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0017002 activin receptor activity 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0031543 peptidyl-proline dioxygenase activity 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0045295 gamma-catenin binding 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0070410 co-SMAD binding 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0097677 STAT family protein binding 2/2506 12/18639 0.166666666666667 1.23962490023943 0.493664966458498 0.77576425049979 GO:0005539 glycosaminoglycan binding 33/2506 242/18639 0.136363636363636 1.01423855474135 0.493759241323841 0.77576425049979 GO:0005004 GPI-linked ephrin receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0005008 hepatocyte growth factor receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0005009 insulin receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0005011 macrophage colony-stimulating factor receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0005018 platelet-derived growth factor alpha-receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0005020 stem cell factor receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0008288 boss receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0035254 glutamate receptor binding 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0036332 placental growth factor receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0038062 protein tyrosine kinase collagen receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0060175 brain-derived neurotrophic factor receptor activity 7/2506 49/18639 0.142857142857143 1.06253562877665 0.494003721769493 0.77576425049979 GO:0005201 extracellular matrix structural constituent 23/2506 168/18639 0.136904761904762 1.01826331091096 0.49701372558197 0.779520283530926 GO:0016835 carbon-oxygen lyase activity 11/2506 79/18639 0.139240506329114 1.03563599260509 0.499871300829 0.7797368315175 GO:0004683 calcium/calmodulin-dependent protein kinase activity 4/2506 27/18639 0.148148148148148 1.10188880021282 0.500861882259457 0.7797368315175 GO:0015252 proton channel activity 4/2506 27/18639 0.148148148148148 1.10188880021282 0.500861882259457 0.7797368315175 GO:0016405 CoA-ligase activity 4/2506 27/18639 0.148148148148148 1.10188880021282 0.500861882259457 0.7797368315175 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/2506 27/18639 0.148148148148148 1.10188880021282 0.500861882259457 0.7797368315175 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 4/2506 27/18639 0.148148148148148 1.10188880021282 0.500861882259457 0.7797368315175 GO:0016859 cis-trans isomerase activity 6/2506 42/18639 0.142857142857143 1.06253562877665 0.504062590728037 0.783752067704137 GO:0070851 growth factor receptor binding 19/2506 139/18639 0.136690647482014 1.01667078149133 0.506723286520365 0.786918798401699 GO:0042379 chemokine receptor binding 10/2506 72/18639 0.138888888888889 1.03302075019952 0.507966986517753 0.786967220448349 GO:0005506 iron ion binding 21/2506 154/18639 0.136363636363636 1.01423855474135 0.508002630804882 0.786967220448349 GO:0031418 L-ascorbic acid binding 3/2506 20/18639 0.15 1.11566241021548 0.515989599164373 0.794085466668183 GO:0043015 gamma-tubulin binding 5/2506 35/18639 0.142857142857143 1.06253562877665 0.515991943365899 0.794085466668183 GO:0005006 epidermal growth factor receptor activity 7/2506 50/18639 0.14 1.04128491620112 0.516375957706511 0.794085466668183 GO:0005007 fibroblast growth factor receptor activity 7/2506 50/18639 0.14 1.04128491620112 0.516375957706511 0.794085466668183 GO:0005017 platelet-derived growth factor receptor activity 7/2506 50/18639 0.14 1.04128491620112 0.516375957706511 0.794085466668183 GO:0005019 platelet-derived growth factor beta-receptor activity 7/2506 50/18639 0.14 1.04128491620112 0.516375957706511 0.794085466668183 GO:0000049 tRNA binding 11/2506 80/18639 0.1375 1.02269054269753 0.517525210965019 0.794883423906077 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 65/2506 484/18639 0.134297520661157 0.998871303911934 0.524659711693892 0.804861187890508 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 36/2506 268/18639 0.134328358208955 0.999100665864612 0.529782588050673 0.809176079007255 GO:0016866 intramolecular transferase activity 4/2506 28/18639 0.142857142857143 1.06253562877665 0.530765135713217 0.809176079007255 GO:0019789 SUMO transferase activity 4/2506 28/18639 0.142857142857143 1.06253562877665 0.530765135713217 0.809176079007255 GO:0051537 2 iron, 2 sulfur cluster binding 4/2506 28/18639 0.142857142857143 1.06253562877665 0.530765135713217 0.809176079007255 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2506 28/18639 0.142857142857143 1.06253562877665 0.530765135713217 0.809176079007255 GO:0003964 RNA-directed DNA polymerase activity 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0005542 folic acid binding 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0017154 semaphorin receptor activity 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0031432 titin binding 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0031994 insulin-like growth factor I binding 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0045159 myosin II binding 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0046974 histone H3K9 methyltransferase activity 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0070123 transforming growth factor beta receptor activity, type III 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0071714 icosanoid transmembrane transporter activity 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/2506 13/18639 0.153846153846154 1.14426913868255 0.537993109215456 0.809176079007255 GO:0005030 neurotrophin receptor activity 7/2506 51/18639 0.137254901960784 1.02086756490306 0.538381229410854 0.809176079007255 GO:0005123 death receptor binding 3/2506 21/18639 0.142857142857143 1.06253562877665 0.550341361433252 0.825184847523581 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/2506 21/18639 0.142857142857143 1.06253562877665 0.550341361433252 0.825184847523581 GO:0003785 actin monomer binding 4/2506 29/18639 0.137931034482759 1.02589646916366 0.559754276064247 0.836315334261867 GO:0043236 laminin binding 4/2506 29/18639 0.137931034482759 1.02589646916366 0.559754276064247 0.836315334261867 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 4/2506 29/18639 0.137931034482759 1.02589646916366 0.559754276064247 0.836315334261867 GO:0042626 ATPase-coupled transmembrane transporter activity 13/2506 98/18639 0.13265306122449 0.986640226721175 0.56575026751769 0.844273476141783 GO:0008013 beta-catenin binding 14/2506 106/18639 0.132075471698113 0.982344260567092 0.571840500246386 0.849076567730917 GO:0004065 arylsulfatase activity 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0004705 JUN kinase activity 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0005161 platelet-derived growth factor receptor binding 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0005347 ATP transmembrane transporter activity 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0008195 phosphatidate phosphatase activity 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0019992 diacylglycerol binding 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0032454 histone H3K9 demethylase activity 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0043176 amine binding 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0061665 SUMO ligase activity 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0098821 BMP receptor activity 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:1990825 sequence-specific mRNA binding 2/2506 14/18639 0.142857142857143 1.06253562877665 0.579559370212001 0.849076567730917 GO:0005003 ephrin receptor activity 7/2506 53/18639 0.132075471698113 0.982344260567092 0.581088880215528 0.849076567730917 GO:0005005 transmembrane-ephrin receptor activity 7/2506 53/18639 0.132075471698113 0.982344260567092 0.581088880215528 0.849076567730917 GO:0038064 collagen receptor activity 7/2506 53/18639 0.132075471698113 0.982344260567092 0.581088880215528 0.849076567730917 GO:1901505 carbohydrate derivative transmembrane transporter activity 7/2506 53/18639 0.132075471698113 0.982344260567092 0.581088880215528 0.849076567730917 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 16/2506 122/18639 0.131147540983607 0.975442544450695 0.582996173420503 0.850877516994507 GO:0098918 structural constituent of synapse 4/2506 30/18639 0.133333333333333 0.99169992019154 0.587741204329566 0.856811166080443 GO:0052689 carboxylic ester hydrolase activity 12/2506 92/18639 0.130434782608696 0.970141226274333 0.591352132400235 0.859716258177283 GO:0035401 histone H3Y41 kinase activity 15/2506 115/18639 0.130434782608696 0.970141226274333 0.591827389452397 0.859716258177283 GO:0140801 histone H2AXY142 kinase activity 15/2506 115/18639 0.130434782608696 0.970141226274333 0.591827389452397 0.859716258177283 GO:0005109 frizzled binding 5/2506 38/18639 0.131578947368421 0.978651237031125 0.592461085135653 0.859716258177283 GO:0015485 cholesterol binding 7/2506 54/18639 0.12962962962963 0.96415270018622 0.601704015860013 0.872125016091353 GO:0099186 structural constituent of postsynapse 3/2506 23/18639 0.130434782608696 0.970141226274333 0.614494204025166 0.881993720886009 GO:0008327 methyl-CpG binding 4/2506 31/18639 0.129032258064516 0.959709600185362 0.614656821836597 0.881993720886009 GO:0016878 acid-thiol ligase activity 4/2506 31/18639 0.129032258064516 0.959709600185362 0.614656821836597 0.881993720886009 GO:0016776 phosphotransferase activity, phosphate group as acceptor 5/2506 39/18639 0.128205128205128 0.953557615568789 0.616411540514973 0.881993720886009 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/2506 39/18639 0.128205128205128 0.953557615568789 0.616411540514973 0.881993720886009 GO:0033218 amide binding 32/2506 247/18639 0.129554655870445 0.963595064153723 0.6181369432652 0.881993720886009 GO:0000774 adenyl-nucleotide exchange factor activity 2/2506 15/18639 0.133333333333333 0.99169992019154 0.618304876497408 0.881993720886009 GO:0004129 cytochrome-c oxidase activity 2/2506 15/18639 0.133333333333333 0.99169992019154 0.618304876497408 0.881993720886009 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/2506 15/18639 0.133333333333333 0.99169992019154 0.618304876497408 0.881993720886009 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/2506 15/18639 0.133333333333333 0.99169992019154 0.618304876497408 0.881993720886009 GO:0008242 omega peptidase activity 2/2506 15/18639 0.133333333333333 0.99169992019154 0.618304876497408 0.881993720886009 GO:0010181 FMN binding 2/2506 15/18639 0.133333333333333 0.99169992019154 0.618304876497408 0.881993720886009 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2506 15/18639 0.133333333333333 0.99169992019154 0.618304876497408 0.881993720886009 GO:0140161 monocarboxylate:sodium symporter activity 2/2506 15/18639 0.133333333333333 0.99169992019154 0.618304876497408 0.881993720886009 GO:0071949 FAD binding 5/2506 40/18639 0.125 0.929718675179569 0.639510706206087 0.910870487390289 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/2506 48/18639 0.125 0.929718675179569 0.63999306251213 0.910870487390289 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2506 24/18639 0.125 0.929718675179569 0.644155964465283 0.915761748805775 GO:0048306 calcium-dependent protein binding 10/2506 80/18639 0.125 0.929718675179569 0.647375216654126 0.918699560563288 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 23/2506 181/18639 0.12707182320442 0.945128376978126 0.647813161375497 0.918699560563288 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/2506 16/18639 0.125 0.929718675179569 0.654236483256013 0.918699560563288 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/2506 16/18639 0.125 0.929718675179569 0.654236483256013 0.918699560563288 GO:0004708 MAP kinase kinase activity 2/2506 16/18639 0.125 0.929718675179569 0.654236483256013 0.918699560563288 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/2506 16/18639 0.125 0.929718675179569 0.654236483256013 0.918699560563288 GO:0016722 oxidoreductase activity, acting on metal ions 2/2506 16/18639 0.125 0.929718675179569 0.654236483256013 0.918699560563288 GO:0022858 alanine transmembrane transporter activity 2/2506 16/18639 0.125 0.929718675179569 0.654236483256013 0.918699560563288 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/2506 16/18639 0.125 0.929718675179569 0.654236483256013 0.918699560563288 GO:0140327 flippase activity 2/2506 16/18639 0.125 0.929718675179569 0.654236483256013 0.918699560563288 GO:0140328 floppase activity 2/2506 16/18639 0.125 0.929718675179569 0.654236483256013 0.918699560563288 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/2506 41/18639 0.121951219512195 0.907042609931287 0.661725184242274 0.926121484272484 GO:0015175 neutral L-amino acid transmembrane transporter activity 5/2506 41/18639 0.121951219512195 0.907042609931287 0.661725184242274 0.926121484272484 GO:0140828 metal cation:monoatomic cation antiporter activity 5/2506 41/18639 0.121951219512195 0.907042609931287 0.661725184242274 0.926121484272484 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4/2506 33/18639 0.121212121212121 0.901545381992309 0.665083328199467 0.929789442194599 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/2506 25/18639 0.12 0.892529928172386 0.672163306591789 0.933477896048729 GO:0015645 fatty acid ligase activity 3/2506 25/18639 0.12 0.892529928172386 0.672163306591789 0.933477896048729 GO:0015662 P-type ion transporter activity 3/2506 25/18639 0.12 0.892529928172386 0.672163306591789 0.933477896048729 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2506 25/18639 0.12 0.892529928172386 0.672163306591789 0.933477896048729 GO:0120515 fatty acid-CoA ligase activity 3/2506 25/18639 0.12 0.892529928172386 0.672163306591789 0.933477896048729 GO:0140358 P-type transmembrane transporter activity 3/2506 25/18639 0.12 0.892529928172386 0.672163306591789 0.933477896048729 GO:0015605 organophosphate ester transmembrane transporter activity 6/2506 50/18639 0.12 0.892529928172386 0.679998355991327 0.94228343615941 GO:0048020 CCR chemokine receptor binding 6/2506 50/18639 0.12 0.892529928172386 0.679998355991327 0.94228343615941 GO:0003774 cytoskeletal motor activity 19/2506 153/18639 0.124183006535948 0.923642082531337 0.681031549864882 0.942679236421093 GO:0042056 chemoattractant activity 5/2506 42/18639 0.119047619047619 0.885446357313875 0.683030940122576 0.94322549676745 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 16/2506 130/18639 0.123076923076923 0.915415310946037 0.686800589499999 0.94322549676745 GO:0008484 sulfuric ester hydrolase activity 2/2506 17/18639 0.117647058823529 0.875029341345477 0.687410175677467 0.94322549676745 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/2506 17/18639 0.117647058823529 0.875029341345477 0.687410175677467 0.94322549676745 GO:0016018 cyclosporin A binding 2/2506 17/18639 0.117647058823529 0.875029341345477 0.687410175677467 0.94322549676745 GO:0030548 acetylcholine receptor regulator activity 2/2506 17/18639 0.117647058823529 0.875029341345477 0.687410175677467 0.94322549676745 GO:0032183 SUMO binding 2/2506 17/18639 0.117647058823529 0.875029341345477 0.687410175677467 0.94322549676745 GO:0045125 bioactive lipid receptor activity 2/2506 17/18639 0.117647058823529 0.875029341345477 0.687410175677467 0.94322549676745 GO:0030165 PDZ domain binding 10/2506 83/18639 0.120481927710843 0.896114385715247 0.693601088764681 0.950187946814984 GO:0016500 protein-hormone receptor activity 8/2506 67/18639 0.119402985074627 0.888089480768544 0.694545955216264 0.950187946814984 GO:0001786 phosphatidylserine binding 7/2506 59/18639 0.11864406779661 0.882444844238235 0.696125214746317 0.950187946814984 GO:0005319 lipid transporter activity 22/2506 178/18639 0.123595505617978 0.91927239793036 0.697655908073203 0.950187946814984 GO:0005227 calcium-activated cation channel activity 3/2506 26/18639 0.115384615384615 0.85820185401191 0.698512471607843 0.950187946814984 GO:0008157 protein phosphatase 1 binding 3/2506 26/18639 0.115384615384615 0.85820185401191 0.698512471607843 0.950187946814984 GO:0008198 ferrous iron binding 3/2506 26/18639 0.115384615384615 0.85820185401191 0.698512471607843 0.950187946814984 GO:0019865 immunoglobulin binding 3/2506 26/18639 0.115384615384615 0.85820185401191 0.698512471607843 0.950187946814984 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/2506 43/18639 0.116279069767442 0.86485458156239 0.703412513776607 0.954793519776428 GO:0008200 ion channel inhibitor activity 5/2506 43/18639 0.116279069767442 0.86485458156239 0.703412513776607 0.954793519776428 GO:0032934 sterol binding 8/2506 68/18639 0.117647058823529 0.875029341345477 0.71061319803747 0.963530368521774 GO:0008201 heparin binding 21/2506 172/18639 0.122093023255814 0.908097310640509 0.716191135443726 0.969265818207173 GO:0070628 proteasome binding 2/2506 18/18639 0.111111111111111 0.826416600159617 0.717917743224028 0.969265818207173 GO:0098641 cadherin binding involved in cell-cell adhesion 2/2506 18/18639 0.111111111111111 0.826416600159617 0.717917743224028 0.969265818207173 GO:0099602 neurotransmitter receptor regulator activity 2/2506 18/18639 0.111111111111111 0.826416600159617 0.717917743224028 0.969265818207173 GO:0016248 channel inhibitor activity 5/2506 44/18639 0.113636363636364 0.84519879561779 0.722862218155203 0.971223536574579 GO:0016790 thiolester hydrolase activity 5/2506 44/18639 0.113636363636364 0.84519879561779 0.722862218155203 0.971223536574579 GO:0019205 nucleobase-containing compound kinase activity 5/2506 44/18639 0.113636363636364 0.84519879561779 0.722862218155203 0.971223536574579 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/2506 44/18639 0.113636363636364 0.84519879561779 0.722862218155203 0.971223536574579 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2506 27/18639 0.111111111111111 0.826416600159617 0.723218795276392 0.971223536574579 GO:0019905 syntaxin binding 7/2506 61/18639 0.114754098360656 0.853512226394359 0.729491734823284 0.978605401715065 GO:0020037 heme binding 17/2506 142/18639 0.119718309859155 0.890434787495925 0.733049959741018 0.981167563533544 GO:0004715 non-membrane spanning protein tyrosine kinase activity 5/2506 45/18639 0.111111111111111 0.826416600159617 0.741379340849262 0.981167563533544 GO:0141110 transporter inhibitor activity 5/2506 45/18639 0.111111111111111 0.826416600159617 0.741379340849262 0.981167563533544 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2506 19/18639 0.105263157894737 0.7829209896249 0.74587614689434 0.981167563533544 GO:0008381 mechanosensitive monoatomic ion channel activity 2/2506 19/18639 0.105263157894737 0.7829209896249 0.74587614689434 0.981167563533544 GO:0008574 plus-end-directed microtubule motor activity 2/2506 19/18639 0.105263157894737 0.7829209896249 0.74587614689434 0.981167563533544 GO:0016918 retinal binding 2/2506 19/18639 0.105263157894737 0.7829209896249 0.74587614689434 0.981167563533544 GO:0030506 ankyrin binding 2/2506 19/18639 0.105263157894737 0.7829209896249 0.74587614689434 0.981167563533544 GO:0042577 lipid phosphatase activity 2/2506 19/18639 0.105263157894737 0.7829209896249 0.74587614689434 0.981167563533544 GO:0042834 peptidoglycan binding 2/2506 19/18639 0.105263157894737 0.7829209896249 0.74587614689434 0.981167563533544 GO:0043395 heparan sulfate proteoglycan binding 2/2506 19/18639 0.105263157894737 0.7829209896249 0.74587614689434 0.981167563533544 GO:0004867 serine-type endopeptidase inhibitor activity 11/2506 95/18639 0.115789473684211 0.86121308858739 0.747087523692086 0.981167563533544 GO:0003730 mRNA 3'-UTR binding 32/2506 262/18639 0.122137404580153 0.908427407809045 0.747849788641546 0.981167563533544 GO:0050661 NADP binding 6/2506 54/18639 0.111111111111111 0.826416600159617 0.750930798249745 0.981167563533544 GO:0019213 deacetylase activity 4/2506 37/18639 0.108108108108108 0.804081016371519 0.75177660427155 0.981167563533544 GO:0046906 tetrapyrrole binding 18/2506 152/18639 0.118421052631579 0.880786113328013 0.753701445714844 0.981167563533544 GO:0004252 serine-type endopeptidase activity 21/2506 176/18639 0.119318181818182 0.88745873539868 0.754451402442985 0.981167563533544 GO:0005200 structural constituent of cytoskeleton 13/2506 112/18639 0.116071428571429 0.863310198381029 0.756101789866829 0.981167563533544 GO:0004896 cytokine receptor activity 11/2506 96/18639 0.114583333333333 0.852242118914605 0.759366333327162 0.981167563533544 GO:0005507 copper ion binding 7/2506 63/18639 0.111111111111111 0.826416600159617 0.760238168383076 0.981167563533544 GO:0001094 TFIID-class transcription factor complex binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0003796 lysozyme activity 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0004090 carbonyl reductase (NADPH) activity 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0004955 prostaglandin receptor activity 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0005345 purine nucleobase transmembrane transporter activity 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0005528 FK506 binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0015187 glycine transmembrane transporter activity 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0015643 toxic substance binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0016868 intramolecular phosphotransferase activity 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0031419 cobalamin binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0031996 thioesterase binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0032052 bile acid binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0043121 neurotrophin binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0043208 glycosphingolipid binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0043295 glutathione binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0043422 protein kinase B binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0047429 nucleoside triphosphate diphosphatase activity 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0140135 mechanosensitive monoatomic cation channel activity 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:1905394 retromer complex binding 1/2506 10/18639 0.1 0.743774940143655 0.764081322275924 0.981167563533544 GO:0035250 UDP-galactosyltransferase activity 3/2506 29/18639 0.103448275862069 0.769422351872747 0.767839268080864 0.98357884819586 GO:0051861 glycolipid binding 3/2506 29/18639 0.103448275862069 0.769422351872747 0.767839268080864 0.98357884819586 GO:0005501 retinoid binding 4/2506 38/18639 0.105263157894737 0.7829209896249 0.770519606522833 0.98357884819586 GO:0019840 isoprenoid binding 4/2506 38/18639 0.105263157894737 0.7829209896249 0.770519606522833 0.98357884819586 GO:0010851 cyclase regulator activity 2/2506 20/18639 0.1 0.743774940143655 0.771419096642114 0.98357884819586 GO:0016408 C-acyltransferase activity 2/2506 20/18639 0.1 0.743774940143655 0.771419096642114 0.98357884819586 GO:0016505 peptidase activator activity involved in apoptotic process 2/2506 20/18639 0.1 0.743774940143655 0.771419096642114 0.98357884819586 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/2506 30/18639 0.1 0.743774940143655 0.78785016405323 0.988084553816196 GO:0022839 monoatomic ion-gated channel activity 3/2506 30/18639 0.1 0.743774940143655 0.78785016405323 0.988084553816196 GO:0048019 receptor antagonist activity 3/2506 30/18639 0.1 0.743774940143655 0.78785016405323 0.988084553816196 GO:0038187 pattern recognition receptor activity 5/2506 48/18639 0.104166666666667 0.774765562649641 0.791416465267104 0.988084553816196 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/2506 21/18639 0.0952380952380952 0.7083570858511 0.794690437190415 0.988084553816196 GO:0009975 cyclase activity 2/2506 21/18639 0.0952380952380952 0.7083570858511 0.794690437190415 0.988084553816196 GO:0015125 bile acid transmembrane transporter activity 2/2506 21/18639 0.0952380952380952 0.7083570858511 0.794690437190415 0.988084553816196 GO:1904047 S-adenosyl-L-methionine binding 2/2506 21/18639 0.0952380952380952 0.7083570858511 0.794690437190415 0.988084553816196 GO:0003953 NAD+ nucleosidase activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0004954 prostanoid receptor activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0005225 volume-sensitive anion channel activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0008046 axon guidance receptor activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0008172 S-methyltransferase activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0015205 nucleobase transmembrane transporter activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0035252 UDP-xylosyltransferase activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0042285 xylosyltransferase activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0047676 arachidonate-CoA ligase activity 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0050786 RAGE receptor binding 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0050998 nitric-oxide synthase binding 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:1900750 oligopeptide binding 1/2506 11/18639 0.0909090909090909 0.676159036494232 0.795817443719723 0.988084553816196 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/2506 57/18639 0.105263157894737 0.7829209896249 0.796109362947863 0.988084553816196 GO:0072341 modified amino acid binding 10/2506 91/18639 0.10989010989011 0.817335099058962 0.797287548554407 0.988573843389486 GO:0005496 steroid binding 12/2506 108/18639 0.111111111111111 0.826416600159617 0.801127122645933 0.992358842491671 GO:0017171 serine hydrolase activity 23/2506 198/18639 0.116161616161616 0.863980991075963 0.804276189824098 0.994762633581958 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/2506 40/18639 0.1 0.743774940143655 0.804645429225691 0.994762633581958 GO:0043178 alcohol binding 10/2506 92/18639 0.108695652173913 0.808451021895277 0.808204335380123 0.99666749958267 GO:0015377 chloride:monoatomic cation symporter activity 2/2506 22/18639 0.0909090909090909 0.676159036494232 0.815839008501785 0.99666749958267 GO:0016881 acid-amino acid ligase activity 2/2506 22/18639 0.0909090909090909 0.676159036494232 0.815839008501785 0.99666749958267 GO:0031683 G-protein beta/gamma-subunit complex binding 2/2506 22/18639 0.0909090909090909 0.676159036494232 0.815839008501785 0.99666749958267 GO:0030246 carbohydrate binding 33/2506 280/18639 0.117857142857143 0.876591893740737 0.817263943187357 0.99666749958267 GO:0098631 cell adhesion mediator activity 8/2506 76/18639 0.105263157894737 0.7829209896249 0.818693574577699 0.99666749958267 GO:0017080 sodium channel regulator activity 4/2506 41/18639 0.0975609756097561 0.725634087945029 0.820096266521196 0.99666749958267 GO:0015297 antiporter activity 15/2506 135/18639 0.111111111111111 0.826416600159617 0.821401170190343 0.99666749958267 GO:0070888 E-box binding 6/2506 59/18639 0.101694915254237 0.756381295061344 0.822538597131659 0.99666749958267 GO:0004000 adenosine deaminase activity 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0004126 cytidine deaminase activity 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0004300 enoyl-CoA hydratase activity 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0004859 phospholipase inhibitor activity 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0005436 sodium:phosphate symporter activity 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0005527 macrolide binding 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0008179 adenylate cyclase binding 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0010853 cyclase activator activity 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0015368 calcium:monoatomic cation antiporter activity 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0097371 MDM2/MDM4 family protein binding 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/2506 12/18639 0.0833333333333333 0.619812450119713 0.823285850743471 0.99666749958267 GO:0008378 galactosyltransferase activity 3/2506 32/18639 0.09375 0.697289006384677 0.823574571423586 0.99666749958267 GO:0022804 active transmembrane transporter activity 55/2506 457/18639 0.12035010940919 0.895133954221029 0.832266320362671 0.999999999999668 GO:0008236 serine-type peptidase activity 22/2506 194/18639 0.11340206185567 0.843456117688681 0.833700338680028 0.999999999999668 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/2506 23/18639 0.0869565217391304 0.646760817516222 0.835014704166225 0.999999999999668 GO:0004602 glutathione peroxidase activity 2/2506 23/18639 0.0869565217391304 0.646760817516222 0.835014704166225 0.999999999999668 GO:0031681 G-protein beta-subunit binding 2/2506 23/18639 0.0869565217391304 0.646760817516222 0.835014704166225 0.999999999999668 GO:0043274 phospholipase binding 2/2506 23/18639 0.0869565217391304 0.646760817516222 0.835014704166225 0.999999999999668 GO:0008194 UDP-glycosyltransferase activity 16/2506 145/18639 0.110344827586207 0.82071717533093 0.835485660006223 0.999999999999668 GO:0019239 deaminase activity 3/2506 33/18639 0.0909090909090909 0.676159036494232 0.839423695745998 0.999999999999668 GO:0019956 chemokine binding 3/2506 33/18639 0.0909090909090909 0.676159036494232 0.839423695745998 0.999999999999668 GO:0031406 carboxylic acid binding 21/2506 187/18639 0.112299465240642 0.835255280375228 0.841607012839645 0.999999999999668 GO:0016836 hydro-lyase activity 6/2506 61/18639 0.0983606557377049 0.731581908338022 0.846171278781893 0.999999999999668 GO:0002161 aminoacyl-tRNA editing activity 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0004465 lipoprotein lipase activity 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0005172 vascular endothelial growth factor receptor binding 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0008253 5'-nucleotidase activity 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0008417 fucosyltransferase activity 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0032396 inhibitory MHC class I receptor activity 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0071837 HMG box domain binding 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0089720 caspase binding 1/2506 13/18639 0.0769230769230769 0.572134569341273 0.847060245870805 0.999999999999668 GO:0004806 triacylglycerol lipase activity 2/2506 24/18639 0.0833333333333333 0.619812450119713 0.852365498684493 0.999999999999668 GO:0019957 C-C chemokine binding 2/2506 24/18639 0.0833333333333333 0.619812450119713 0.852365498684493 0.999999999999668 GO:0030552 cAMP binding 2/2506 24/18639 0.0833333333333333 0.619812450119713 0.852365498684493 0.999999999999668 GO:0015020 glucuronosyltransferase activity 3/2506 34/18639 0.0882352941176471 0.656272006009108 0.854025660453542 0.999999999999668 GO:0051427 hormone receptor binding 3/2506 34/18639 0.0882352941176471 0.656272006009108 0.854025660453542 0.999999999999668 GO:0043177 organic acid binding 21/2506 189/18639 0.111111111111111 0.826416600159617 0.854637769112577 0.999999999999668 GO:0005246 calcium channel regulator activity 5/2506 53/18639 0.0943396226415094 0.701674471833637 0.857568711739409 0.999999999999668 GO:0030547 signaling receptor inhibitor activity 4/2506 44/18639 0.0909090909090909 0.676159036494232 0.860482480543702 0.999999999999668 GO:0005516 calmodulin binding 23/2506 207/18639 0.111111111111111 0.826416600159617 0.863982604223143 0.999999999999668 GO:0005313 L-glutamate transmembrane transporter activity 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0008494 translation activator activity 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0015386 potassium:proton antiporter activity 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0015926 glucosidase activity 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0031404 chloride ion binding 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0042043 neurexin family protein binding 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0042813 Wnt receptor activity 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0044548 S100 protein binding 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0046030 inositol trisphosphate phosphatase activity 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0061783 peptidoglycan muralytic activity 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:1901474 azole transmembrane transporter activity 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:1901612 cardiolipin binding 1/2506 14/18639 0.0714285714285714 0.531267814388325 0.867637236306098 0.999999999999668 GO:0005537 D-mannose binding 2/2506 25/18639 0.08 0.595019952114924 0.868035254518641 0.999999999999668 GO:0047617 fatty acyl-CoA hydrolase activity 2/2506 25/18639 0.08 0.595019952114924 0.868035254518641 0.999999999999668 GO:1901681 sulfur compound binding 31/2506 275/18639 0.112727272727273 0.838437205252848 0.877213981253866 0.999999999999668 GO:0098632 cell-cell adhesion mediator activity 5/2506 55/18639 0.0909090909090909 0.676159036494232 0.878620596674146 0.999999999999668 GO:0004033 aldo-keto reductase (NADPH) activity 3/2506 36/18639 0.0833333333333333 0.619812450119713 0.87977812836549 0.999999999999668 GO:0004190 aspartic-type endopeptidase activity 3/2506 36/18639 0.0833333333333333 0.619812450119713 0.87977812836549 0.999999999999668 GO:0016289 acyl-CoA hydrolase activity 2/2506 26/18639 0.0769230769230769 0.572134569341273 0.88216215309454 0.999999999999668 GO:0004467 long-chain fatty acid-CoA ligase activity 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0004953 icosanoid receptor activity 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0005523 tropomyosin binding 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0008020 G protein-coupled photoreceptor activity 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0008252 nucleotidase activity 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0016846 carbon-sulfur lyase activity 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0017081 chloride channel regulator activity 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0031005 filamin binding 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0033130 acetylcholine receptor binding 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0034483 heparan sulfate sulfotransferase activity 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0045504 dynein heavy chain binding 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0048531 beta-1,3-galactosyltransferase activity 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0051371 muscle alpha-actinin binding 1/2506 15/18639 0.0666666666666667 0.49584996009577 0.885446690578148 0.999999999999668 GO:0160215 deacylase activity 6/2506 65/18639 0.0923076923076923 0.686561483209528 0.88573565409375 0.999999999999668 GO:0022829 wide pore channel activity 3/2506 37/18639 0.0810810810810811 0.603060762278639 0.891072380491426 0.999999999999668 GO:0042805 actinin binding 3/2506 37/18639 0.0810810810810811 0.603060762278639 0.891072380491426 0.999999999999668 GO:0070001 aspartic-type peptidase activity 3/2506 37/18639 0.0810810810810811 0.603060762278639 0.891072380491426 0.999999999999668 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/2506 16/18639 0.0625 0.464859337589785 0.900860704399623 0.999999999999668 GO:0008142 oxysterol binding 1/2506 16/18639 0.0625 0.464859337589785 0.900860704399623 0.999999999999668 GO:0015378 sodium:chloride symporter activity 1/2506 16/18639 0.0625 0.464859337589785 0.900860704399623 0.999999999999668 GO:0015562 efflux transmembrane transporter activity 1/2506 16/18639 0.0625 0.464859337589785 0.900860704399623 0.999999999999668 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/2506 16/18639 0.0625 0.464859337589785 0.900860704399623 0.999999999999668 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/2506 16/18639 0.0625 0.464859337589785 0.900860704399623 0.999999999999668 GO:0097027 ubiquitin-protein transferase activator activity 1/2506 16/18639 0.0625 0.464859337589785 0.900860704399623 0.999999999999668 GO:0042887 amide transmembrane transporter activity 3/2506 38/18639 0.0789473684210526 0.587190742218675 0.90140547540302 0.999999999999668 GO:0045499 chemorepellent activity 2/2506 28/18639 0.0714285714285714 0.531267814388325 0.906305651511994 0.999999999999668 GO:0050698 proteoglycan sulfotransferase activity 2/2506 28/18639 0.0714285714285714 0.531267814388325 0.906305651511994 0.999999999999668 GO:0051393 alpha-actinin binding 2/2506 28/18639 0.0714285714285714 0.531267814388325 0.906305651511994 0.999999999999668 GO:0003777 microtubule motor activity 6/2506 68/18639 0.0882352941176471 0.656272006009108 0.909428453556099 0.999999999999668 GO:0003823 antigen binding 18/2506 174/18639 0.103448275862069 0.769422351872747 0.909811261483837 0.999999999999668 GO:0015459 potassium channel regulator activity 5/2506 59/18639 0.0847457627118644 0.630317745884454 0.912845904819974 0.999999999999668 GO:0004549 tRNA-specific ribonuclease activity 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0008569 minus-end-directed microtubule motor activity 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0009881 photoreceptor activity 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0015278 intracellularly gated calcium channel activity 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0038191 neuropilin binding 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0045236 CXCR chemokine receptor binding 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0070402 NADPH binding 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0070492 oligosaccharide binding 1/2506 17/18639 0.0588235294117647 0.437514670672738 0.914201362444758 0.999999999999668 GO:0015144 carbohydrate transmembrane transporter activity 3/2506 40/18639 0.075 0.557831205107741 0.919455706037154 0.999999999999668 GO:0016782 transferase activity, transferring sulphur-containing groups 6/2506 70/18639 0.0857142857142857 0.63752137726599 0.922749349209063 0.999999999999668 GO:0015291 secondary active transmembrane transporter activity 31/2506 287/18639 0.10801393728223 0.803380597367711 0.92417026604346 0.999999999999668 GO:0015172 acidic amino acid transmembrane transporter activity 1/2506 18/18639 0.0555555555555556 0.413208300079808 0.925747457693036 0.999999999999668 GO:0015373 monoatomic anion:sodium symporter activity 1/2506 18/18639 0.0555555555555556 0.413208300079808 0.925747457693036 0.999999999999668 GO:0016854 racemase and epimerase activity 1/2506 18/18639 0.0555555555555556 0.413208300079808 0.925747457693036 0.999999999999668 GO:0032393 MHC class I receptor activity 1/2506 18/18639 0.0555555555555556 0.413208300079808 0.925747457693036 0.999999999999668 GO:0004812 aminoacyl-tRNA ligase activity 3/2506 41/18639 0.0731707317073171 0.544225565958772 0.927299872314729 0.999999999999668 GO:0016875 ligase activity, forming carbon-oxygen bonds 3/2506 41/18639 0.0731707317073171 0.544225565958772 0.927299872314729 0.999999999999668 GO:0004866 endopeptidase inhibitor activity 16/2506 161/18639 0.0993788819875776 0.739155220018539 0.927990809858431 0.999999999999668 GO:0001664 G protein-coupled receptor binding 32/2506 297/18639 0.107744107744108 0.801373672882053 0.929365177211771 0.999999999999668 GO:0015101 organic cation transmembrane transporter activity 7/2506 81/18639 0.0864197530864197 0.642768466790813 0.931638536298378 0.999999999999668 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/2506 52/18639 0.0769230769230769 0.572134569341273 0.932300332485035 0.999999999999668 GO:0015179 L-amino acid transmembrane transporter activity 5/2506 62/18639 0.0806451612903226 0.599818500115851 0.932638674540771 0.999999999999668 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/2506 31/18639 0.0645161290322581 0.479854800092681 0.933987157386215 0.999999999999668 GO:0047499 calcium-independent phospholipase A2 activity 2/2506 31/18639 0.0645161290322581 0.479854800092681 0.933987157386215 0.999999999999668 GO:0072349 modified amino acid transmembrane transporter activity 2/2506 31/18639 0.0645161290322581 0.479854800092681 0.933987157386215 0.999999999999668 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/2506 19/18639 0.0526315789473684 0.39146049481245 0.935740308292964 0.999999999999668 GO:0005229 intracellularly calcium-gated chloride channel activity 1/2506 19/18639 0.0526315789473684 0.39146049481245 0.935740308292964 0.999999999999668 GO:0015245 fatty acid transmembrane transporter activity 1/2506 19/18639 0.0526315789473684 0.39146049481245 0.935740308292964 0.999999999999668 GO:0022821 solute:potassium antiporter activity 1/2506 19/18639 0.0526315789473684 0.39146049481245 0.935740308292964 0.999999999999668 GO:0022840 leak channel activity 1/2506 19/18639 0.0526315789473684 0.39146049481245 0.935740308292964 0.999999999999668 GO:0022842 narrow pore channel activity 1/2506 19/18639 0.0526315789473684 0.39146049481245 0.935740308292964 0.999999999999668 GO:0034987 immunoglobulin receptor binding 1/2506 19/18639 0.0526315789473684 0.39146049481245 0.935740308292964 0.999999999999668 GO:0050145 nucleoside monophosphate kinase activity 1/2506 19/18639 0.0526315789473684 0.39146049481245 0.935740308292964 0.999999999999668 GO:0141147 intracellularly calcium-gated channel activity 1/2506 19/18639 0.0526315789473684 0.39146049481245 0.935740308292964 0.999999999999668 GO:0015106 bicarbonate transmembrane transporter activity 2/2506 32/18639 0.0625 0.464859337589785 0.94134799645039 0.999999999999668 GO:0042910 xenobiotic transmembrane transporter activity 2/2506 32/18639 0.0625 0.464859337589785 0.94134799645039 0.999999999999668 GO:0047498 calcium-dependent phospholipase A2 activity 2/2506 32/18639 0.0625 0.464859337589785 0.94134799645039 0.999999999999668 GO:0001972 retinoic acid binding 1/2506 20/18639 0.05 0.371887470071828 0.944388793116693 0.999999999999668 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2506 20/18639 0.05 0.371887470071828 0.944388793116693 0.999999999999668 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/2506 20/18639 0.05 0.371887470071828 0.944388793116693 0.999999999999668 GO:0030627 pre-mRNA 5'-splice site binding 1/2506 20/18639 0.05 0.371887470071828 0.944388793116693 0.999999999999668 GO:0052745 inositol phosphate phosphatase activity 1/2506 20/18639 0.05 0.371887470071828 0.944388793116693 0.999999999999668 GO:0005248 voltage-gated sodium channel activity 1/2506 21/18639 0.0476190476190476 0.35417854292555 0.951873710913006 0.999999999999668 GO:0008373 sialyltransferase activity 1/2506 21/18639 0.0476190476190476 0.35417854292555 0.951873710913006 0.999999999999668 GO:0015174 basic amino acid transmembrane transporter activity 1/2506 21/18639 0.0476190476190476 0.35417854292555 0.951873710913006 0.999999999999668 GO:0036122 BMP binding 1/2506 21/18639 0.0476190476190476 0.35417854292555 0.951873710913006 0.999999999999668 GO:0061891 calcium ion sensor activity 1/2506 21/18639 0.0476190476190476 0.35417854292555 0.951873710913006 0.999999999999668 GO:0170055 lipid transmembrane transporter activity 4/2506 56/18639 0.0714285714285714 0.531267814388325 0.95381770458647 0.999999999999668 GO:0030414 peptidase inhibitor activity 16/2506 169/18639 0.0946745562130177 0.704165623804644 0.954605778474316 0.999999999999668 GO:0004180 carboxypeptidase activity 3/2506 46/18639 0.0652173913043478 0.485070613137166 0.956975690463485 0.999999999999668 GO:0008970 phospholipase A1 activity 1/2506 22/18639 0.0454545454545455 0.338079518247116 0.958351553884969 0.999999999999668 GO:0033691 sialic acid binding 1/2506 22/18639 0.0454545454545455 0.338079518247116 0.958351553884969 0.999999999999668 GO:0140784 metal ion sensor activity 1/2506 22/18639 0.0454545454545455 0.338079518247116 0.958351553884969 0.999999999999668 GO:0015294 solute:monoatomic cation symporter activity 10/2506 116/18639 0.0862068965517241 0.641185293227289 0.958962747813158 0.999999999999668 GO:0004623 phospholipase A2 activity 2/2506 35/18639 0.0571428571428571 0.42501425151066 0.959025078336189 0.999999999999668 GO:0005343 organic acid:sodium symporter activity 2/2506 35/18639 0.0571428571428571 0.42501425151066 0.959025078336189 0.999999999999668 GO:0140359 ABC-type transporter activity 3/2506 47/18639 0.0638297872340425 0.474749961793822 0.961347754152049 0.999999999999668 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/2506 36/18639 0.0555555555555556 0.413208300079808 0.963686663628583 0.999999999999668 GO:0005212 structural constituent of eye lens 1/2506 23/18639 0.0434782608695652 0.323380408758111 0.96395777432673 0.999999999999668 GO:0005283 amino acid:sodium symporter activity 1/2506 23/18639 0.0434782608695652 0.323380408758111 0.96395777432673 0.999999999999668 GO:0016493 C-C chemokine receptor activity 1/2506 23/18639 0.0434782608695652 0.323380408758111 0.96395777432673 0.999999999999668 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/2506 70/18639 0.0714285714285714 0.531267814388325 0.96723691396817 0.999999999999668 GO:0030551 cyclic nucleotide binding 2/2506 37/18639 0.0540540540540541 0.40204050818576 0.967836051236421 0.999999999999668 GO:0005315 phosphate transmembrane transporter activity 1/2506 24/18639 0.0416666666666667 0.309906225059856 0.968809612398132 0.999999999999668 GO:0015149 hexose transmembrane transporter activity 1/2506 24/18639 0.0416666666666667 0.309906225059856 0.968809612398132 0.999999999999668 GO:0030215 semaphorin receptor binding 1/2506 24/18639 0.0416666666666667 0.309906225059856 0.968809612398132 0.999999999999668 GO:0055056 D-glucose transmembrane transporter activity 1/2506 24/18639 0.0416666666666667 0.309906225059856 0.968809612398132 0.999999999999668 GO:0000146 microfilament motor activity 2/2506 38/18639 0.0526315789473684 0.39146049481245 0.971526638782721 0.999999999999668 GO:0042562 hormone binding 7/2506 94/18639 0.074468085106383 0.553874955426126 0.976288438795358 0.999999999999668 GO:0001637 G protein-coupled chemoattractant receptor activity 1/2506 26/18639 0.0384615384615385 0.286067284670637 0.976642399611721 0.999999999999668 GO:0004950 chemokine receptor activity 1/2506 26/18639 0.0384615384615385 0.286067284670637 0.976642399611721 0.999999999999668 GO:0005112 Notch binding 1/2506 26/18639 0.0384615384615385 0.286067284670637 0.976642399611721 0.999999999999668 GO:0015145 monosaccharide transmembrane transporter activity 1/2506 26/18639 0.0384615384615385 0.286067284670637 0.976642399611721 0.999999999999668 GO:1901682 sulfur compound transmembrane transporter activity 4/2506 63/18639 0.0634920634920635 0.472238057234067 0.976998585205249 0.999999999999668 GO:0071855 neuropeptide receptor binding 2/2506 40/18639 0.05 0.371887470071828 0.977719942697149 0.999999999999668 GO:0004364 glutathione transferase activity 1/2506 27/18639 0.037037037037037 0.275472200053206 0.979787198761402 0.999999999999668 GO:0008395 steroid hydroxylase activity 1/2506 27/18639 0.037037037037037 0.275472200053206 0.979787198761402 0.999999999999668 GO:0017046 peptide hormone binding 3/2506 53/18639 0.0566037735849057 0.421004683100182 0.979954352170255 0.999999999999668 GO:0015293 symporter activity 12/2506 146/18639 0.0821917808219178 0.611321868611224 0.981654999417679 0.999999999999668 GO:0051119 sugar transmembrane transporter activity 1/2506 28/18639 0.0357142857142857 0.265633907194163 0.982508737548417 0.999999999999668 GO:0004181 metallocarboxypeptidase activity 1/2506 29/18639 0.0344827586206897 0.256474117290916 0.984863963151752 0.999999999999668 GO:0005416 amino acid:monoatomic cation symporter activity 1/2506 29/18639 0.0344827586206897 0.256474117290916 0.984863963151752 0.999999999999668 GO:0099604 ligand-gated calcium channel activity 1/2506 29/18639 0.0344827586206897 0.256474117290916 0.984863963151752 0.999999999999668 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/2506 30/18639 0.0333333333333333 0.247924980047885 0.986902163492521 0.999999999999668 GO:0015171 amino acid transmembrane transporter activity 7/2506 102/18639 0.0686274509803922 0.510433782451528 0.988239479491697 0.999999999999668 GO:0005184 neuropeptide hormone activity 1/2506 31/18639 0.032258064516129 0.23992740004634 0.988665997029398 0.999999999999668 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/2506 46/18639 0.0434782608695652 0.323380408758111 0.989439660176536 0.999999999999668 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/2506 32/18639 0.03125 0.232429668794892 0.99019238414485 0.999999999999668 GO:0160041 neuropeptide activity 1/2506 32/18639 0.03125 0.232429668794892 0.99019238414485 0.999999999999668 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/2506 34/18639 0.0294117647058824 0.218757335336369 0.992656335986714 0.999999999999668 GO:0016229 steroid dehydrogenase activity 1/2506 35/18639 0.0285714285714286 0.21250712575533 0.993645490623494 0.999999999999668 GO:0099106 ion channel regulator activity 12/2506 160/18639 0.075 0.557831205107741 0.993656480158425 0.999999999999668 GO:0016597 amino acid binding 2/2506 51/18639 0.0392156862745098 0.291676447115159 0.994390092643459 0.999999999999668 GO:0055106 ubiquitin-protein transferase regulator activity 1/2506 36/18639 0.0277777777777778 0.206604150039904 0.994501457109063 0.999999999999668 GO:0030280 structural constituent of skin epidermis 1/2506 37/18639 0.027027027027027 0.20102025409288 0.995242162827748 0.999999999999668 GO:0005544 calcium-dependent phospholipid binding 2/2506 53/18639 0.0377358490566038 0.280669788733455 0.99565404692298 0.999999999999668 GO:0008146 sulfotransferase activity 2/2506 53/18639 0.0377358490566038 0.280669788733455 0.99565404692298 0.999999999999668 GO:0005125 cytokine activity 19/2506 234/18639 0.0811965811965812 0.603919823193566 0.995989761299305 0.999999999999668 GO:0016247 channel regulator activity 12/2506 168/18639 0.0714285714285714 0.531267814388325 0.996662194950215 0.999999999999668 GO:0141108 transporter regulator activity 12/2506 170/18639 0.0705882352941176 0.525017604807286 0.997167668137872 0.999999999999668 GO:0005254 chloride channel activity 4/2506 83/18639 0.0481927710843374 0.358445754286099 0.997294063229631 0.999999999999668 GO:0008227 G protein-coupled amine receptor activity 1/2506 41/18639 0.024390243902439 0.181408521986257 0.99733301203255 0.999999999999668 GO:0008307 structural constituent of muscle 1/2506 42/18639 0.0238095238095238 0.177089271462775 0.997692377117313 0.999999999999668 GO:0005245 voltage-gated calcium channel activity 1/2506 43/18639 0.0232558139534884 0.172970916312478 0.998003336032408 0.999999999999668 GO:0005179 hormone activity 8/2506 132/18639 0.0606060606060606 0.450772690996155 0.998018617388249 0.999999999999668 GO:0003735 structural constituent of ribosome 12/2506 175/18639 0.0685714285714286 0.510017101812792 0.998132788693925 0.999999999999668 GO:0046943 carboxylic acid transmembrane transporter activity 13/2506 188/18639 0.0691489361702128 0.514312458609974 0.998513751586507 0.999999999999668 GO:0005342 organic acid transmembrane transporter activity 13/2506 189/18639 0.0687830687830688 0.511591228670239 0.998632429859288 0.999999999999668 GO:0005253 monoatomic anion channel activity 5/2506 103/18639 0.0485436893203883 0.36105579618624 0.998851250211388 0.999999999999668 GO:0099095 ligand-gated monoatomic anion channel activity 1/2506 47/18639 0.0212765957446809 0.158249987264608 0.998881002336634 0.999999999999668 GO:0015370 solute:sodium symporter activity 3/2506 79/18639 0.0379746835443038 0.282446179801388 0.999042401906362 0.999999999999668 GO:0005272 sodium channel activity 1/2506 51/18639 0.0196078431372549 0.145838223557579 0.999372960128882 0.999999999999668 GO:0015108 chloride transmembrane transporter activity 6/2506 121/18639 0.0495867768595041 0.368814019905945 0.999392998751274 0.999999999999668 GO:0008509 monoatomic anion transmembrane transporter activity 8/2506 149/18639 0.0536912751677852 0.39934224974156 0.999620927576347 0.999999999999668 GO:0008083 growth factor activity 9/2506 162/18639 0.0555555555555556 0.413208300079808 0.999676442548994 0.999999999999668 GO:0008514 organic anion transmembrane transporter activity 19/2506 269/18639 0.0706319702602231 0.525342894525258 0.999705973471396 0.999999999999668 GO:0015085 calcium ion transmembrane transporter activity 7/2506 147/18639 0.0476190476190476 0.35417854292555 0.99986166689939 0.999999999999668 GO:0004497 monooxygenase activity 3/2506 106/18639 0.0283018867924528 0.210502341550091 0.999966960244654 0.999999999999668 GO:0015081 sodium ion transmembrane transporter activity 7/2506 164/18639 0.0426829268292683 0.31746491347595 0.999977966765711 0.999999999999668 GO:0015103 inorganic anion transmembrane transporter activity 7/2506 165/18639 0.0424242424242424 0.315540883697308 0.999980264243583 0.999999999999668 GO:0005262 calcium channel activity 4/2506 131/18639 0.0305343511450382 0.227106851952261 0.999990717217332 0.999999999999668 GO:0099094 ligand-gated monoatomic cation channel activity 4/2506 136/18639 0.0294117647058824 0.218757335336369 0.999995002273832 0.999999999999668 GO:0046873 metal ion transmembrane transporter activity 29/2506 450/18639 0.0644444444444444 0.479321628092578 0.999999506106183 0.999999999999668 GO:0022832 voltage-gated channel activity 5/2506 175/18639 0.0285714285714286 0.21250712575533 0.99999975051745 0.999999999999668 GO:0015079 potassium ion transmembrane transporter activity 4/2506 160/18639 0.025 0.185943735035914 0.999999756688615 0.999999999999668 GO:0005244 voltage-gated monoatomic ion channel activity 4/2506 173/18639 0.023121387283237 0.171971084426279 0.999999954041619 0.999999999999668 GO:0008528 G protein-coupled peptide receptor activity 1/2506 122/18639 0.00819672131147541 0.0609651590281685 0.999999978969573 0.999999999999668 GO:0001653 peptide receptor activity 1/2506 128/18639 0.0078125 0.0581074171987231 0.999999991212203 0.999999999999668 GO:0015276 ligand-gated monoatomic ion channel activity 4/2506 186/18639 0.021505376344086 0.159951600030894 0.999999991467513 0.999999999999668 GO:0022834 ligand-gated channel activity 4/2506 188/18639 0.0212765957446809 0.158249987264608 0.999999993423965 0.999999999999668 GO:0022843 voltage-gated monoatomic cation channel activity 1/2506 143/18639 0.00699300699300699 0.0520122335764794 0.999999999009439 0.999999999999668 GO:0005261 monoatomic cation channel activity 12/2506 341/18639 0.0351906158357771 0.261738981868735 0.999999999922908 0.999999999999668 GO:0045182 translation regulator activity 13/2506 356/18639 0.0365168539325843 0.271603208479425 0.999999999936473 0.999999999999668 GO:0022836 gated channel activity 8/2506 318/18639 0.0251572327044025 0.18711319248897 0.999999999998682 0.999999999999668 GO:0005216 monoatomic ion channel activity 17/2506 448/18639 0.0379464285714286 0.282236026393798 0.999999999999268 0.999999999999668 GO:0030371 translation repressor activity 8/2506 329/18639 0.0243161094224924 0.180857128302409 0.999999999999668 0.999999999999668