category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04518	Integrin signaling	13/114	154/9376	6.94281157439052	HGF/SPP1/PTK2/LAMC3/NCK2/ARHGEF6/ITGA1/PDGFRB/FLT1/FERMT2/RAC3/LAMA2/COL4A5	8.24945841340199
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	12/114	203/9376	4.86180969665543	HGF/PPP1R12A/SPP1/PTK2/LAMC3/ITGA1/PDGFRB/FLT1/SHC2/RAC3/LAMA2/COL4A5	6.17118927032655
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/114	238/9376	4.1468376824414	AGTR1/RPS4Y1/F13A1/C7/RPL23A/RPL13A/RPS2/C1QA/RPL4/RPLP0/PLCG2/RPL27	5.45535377275575
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/114	134/9376	5.52395915161037	AGTR1/PLA2G2A/PPP1R12A/CALD1/PLA2G5/PLCB1/GUCY1A2/GUCY1B1/GNAS	5.85158836225602
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/114	155/9376	4.77555178268251	AGTR1/KCNK3/WNT3A/PDE8B/PLCB1/WNT6/GNAS/LEF1/WNT2	5.25827075504133
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	14/114	362/9376	3.18076960356693	AREG/IGF2/HGF/SPP1/PTK2/LAMC3/PRLR/ITGA1/PDGFRB/FLT1/CSH1/LAMA2/IRS1/COL4A5	4.69451757308307
Organismal Systems	Immune system	hsa04611	Platelet activation	8/114	126/9376	5.22194374825954	PPP1R12A/PLCB1/GUCY1A2/GUCY1B1/P2RY1/GNAS/VAMP8/PLCG2	5.29312955992583
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	10/114	204/9376	4.03164774681803	IGF2/HGF/EZR/WNT3A/PPP1R12A/PTK2/WNT6/TWIST1/PLCG2/WNT2	4.85676929898259
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/114	170/9376	4.35417956656347	IGF2/HGF/WNT3A/WNT6/LEF1/MGST2/SHC2/PLCG2/WNT2	4.89622040928909
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/114	101/9376	5.70019107173875	EDNRB/WNT3A/PLCB1/WNT6/GNAS/LEF1/WNT2	5.26871754176594
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/114	103/9376	5.58950774995742	PTK2/PLCB1/LAMC3/GNAL/GNAS/LAMA2/COL4A5	5.1958937964352
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/114	184/9376	4.02288329519451	PTK2/SEMA6D/SEMA3A/NCK2/TRPC6/DPYSL2/NTNG1/RAC3/PLCG2	4.59421123833725
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/114	149/9376	4.41587189450135	AGTR1/PLCB1/GNAS/DGKG/PDGFRB/SHC2/DGKD/PLCG2	4.6628358236353
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/114	122/9376	4.71901064135749	PTK2/PLCB1/GNAS/SHC2/CSH1/PLCG2/IRS1	4.58699497449618
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	12/114	333/9376	2.96380591117433	WNT3A/SPP1/PTK2/LAMC3/WNT6/GNAS/ITGA1/NOTCH3/PDGFRB/WNT2/LAMA2/COL4A5	4.04808935066432
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/114	89/9376	5.54464813719692	PLCB1/GUCY1A2/GUCY1B1/GNAS/PDGFRB/TJP1	4.77906811343315
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/114	166/9376	3.96364404988375	AGTR1/EDNRB/PPP1R12A/PLCB1/GUCY1A2/GUCY1B1/TRPC6/IRS1	4.27401405226335
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/114	254/9376	3.238016300594	AGTR1/HGF/EDNRB/PLCB1/GNAL/GNAS/CYSLTR2/PDGFRB/FLT1/PLCG2	4.01162884412954
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/114	65/9376	6.32658569500675	AGTR1/KCNK3/PDE8B/PLCB1/GNAS	4.78071780417418
NA	NA	hsa04519	Cadherin signaling	13/114	404/9376	2.64651728330728	WNT3A/MYO1B/PTK2/LHFPL6/DSP/WNT6/CDH19/PCDH18/LEF1/PDGFRB/RAC3/TJP1/WNT2	3.75316812646043
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	8/114	178/9376	3.69643209146462	WNT3A/PLCB1/WNT6/FRZB/LEF1/GPC4/RAC3/WNT2	4.02938217887112
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/114	69/9376	5.95982710399186	AGTR1/PLCB1/GUCY1A2/GUCY1B1/GNAS	4.58745589132805
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/114	238/9376	3.11012826183105	IGF2/HGF/PLA2G2A/PLA2G5/PDGFRB/FLT1/SHC2/RAC3/PLCG2	3.65811565000951
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/114	80/9376	5.14035087719298	HGF/GAS6/PDGFRB/SHC2/PLCG2	4.12591008070712
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/114	86/9376	4.78172174622603	AREG/PTK2/NCK2/SHC2/PLCG2	3.90855848718661
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/114	88/9376	4.67304625199362	F13A1/TFPI/C7/C1QA/PLAT	3.84054011184168
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/114	89/9376	4.62054011433077	SPP1/LAMC3/ITGA1/LAMA2/COL4A5	3.8072931702202
NA	NA	hsa04081	Hormone signaling	8/114	219/9376	3.00440599214932	IGF2/AGTR1/PLCB1/PRLR/GNAS/CSH1/CGA/IRS1	3.32978979723773
Genetic Information Processing	Translation	hsa03010	Ribosome	8/114	222/9376	2.96380591117433	RPS4Y1/RPL23A/RPL13A/RPS2/RPL4/RPLP0/RACK1/RPL27	3.28515051001612
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/114	60/9376	5.48304093567251	PTK2/SHC2/RAC3/PLCG2	3.86473095167827
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/114	60/9376	5.48304093567251	PLCB1/GUCY1A2/GUCY1B1/GNAS	3.86473095167827
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/114	63/9376	5.22194374825954	WNT3A/WNT6/LEF1/WNT2	3.73012676706541
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/114	232/9376	2.83605565638234	EZR/PPP1R12A/PTK2/C7/ARHGEF6/ITGA1/PDGFRB/RAC3	3.14157477488466
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/114	102/9376	4.03164774681803	PLA2G2A/PLA2G5/PLCB1/SLC4A4/GNAS	3.41531648196491
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/114	148/9376	3.33428165007112	WNT3A/WNT6/LEF1/NOTCH3/SHC2/WNT2	3.17552836480402
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/114	150/9376	3.28982456140351	HGF/WNT3A/WNT6/LEF1/SHC2/WNT2	3.13636637672203
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/114	157/9376	3.14314448541736	AREG/WNT3A/WNT6/BMP5/LEF1/WNT2	3.00431208891685
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/114	370/9376	2.22285443338075	AGTR1/EDNRB/P2RY1/PRLR/GRID1/P2RY14/NR3C1/CYSLTR2/CSH1/CGA	2.66253501969771
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/114	212/9376	2.71565706719629	HGF/PLCB1/P2RY1/GNAS/PDGFRB/FLT1/RAC3	2.80311909153318
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/114	86/9376	3.82537739698082	DSP/ITGA1/LEF1/LAMA2	2.92013890643729
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/114	130/9376	3.16329284750337	EDNRB/PLCB1/GNAS/SHC2/COL4A5	2.75547021877818
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/114	51/9376	4.83797729618163	PLA2G2A/ENPP2/PLA2G5	3.04893906399786
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/114	51/9376	4.83797729618163	GNAS/TJP1/PLCG2	3.04893906399786
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/114	52/9376	4.74493927125506	GNAS/HSD17B2/CGA	3.00421489068985
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/114	93/9376	3.53744576495001	PLCB1/GUCY1A2/GUCY1B1/GNAS	2.7282222284186
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/114	93/9376	3.53744576495001	PTK2/LAMC3/LAMA2/COL4A5	2.7282222284186
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	5/114	140/9376	2.93734335839599	AGTR1/SPP1/PLCB1/NOTCH3/PLAT	2.56220768512808
NA	NA	hsa04517	IgSF CAM signaling	8/114	299/9376	2.2005515460893	EZR/PTK2/NCK2/PTPRD/CADM1/TRPC6/TJP1/PLCG2	2.34062000919856
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/114	143/9376	2.87572077045761	H3-3A/H2AJ/H3-3B/C7/C1QA	2.5075549799275
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/114	97/9376	3.39157171278712	PLCB1/GUCY1A2/GUCY1B1/GNAS	2.62666304105101
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/114	98/9376	3.35696383816685	PLCB1/DGKG/DGKD/PLCG2	2.60210279197965
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/114	98/9376	3.35696383816685	AGTR1/KCNK3/PLCB1/GNAS	2.60210279197965
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/114	99/9376	3.3230551125288	PTK2/GNAS/NOTCH3/SHC2	2.57785810059852
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/114	99/9376	3.3230551125288	DGKG/PDGFRB/DGKD/RAC3	2.57785810059852
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/114	101/9376	3.25725204099357	AGTR1/PLCB1/PLCG2/COL4A5	2.53028509757376
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/114	59/9376	4.18198037466548	GNAS/CGA/IRS1	2.72001394357902
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	6/114	200/9376	2.46736842105263	EZR/MYO1B/NCK2/MYO10/BAIAP2L1/TJP1	2.32708978291013
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/114	103/9376	3.1940044285471	PLCB1/GNAL/GNAS/C1QA	2.4838859896783
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/114	104/9376	3.16329284750337	PLA2G2A/PLA2G5/DGKG/DGKD	2.46110956384953
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	6/114	205/9376	2.40718870346598	COX4I2/AGTR1/NDUFA4L2/PLCB1/PDK4/IRS1	2.25999042630548
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/114	26/9376	6.32658569500675	PLA2G2A/PLA2G5	3.0172789470816
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/114	154/9376	2.67031214399635	PPP1R12A/PLCB1/GUCY1A2/GUCY1B1/GNAS	2.31862821104359
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/114	158/9376	2.60270930490784	WNT3A/WNT6/RPS6KA2/WNT2/IRS1	2.25398294432282
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/114	65/9376	3.79595141700405	LIPG/DGKG/DGKD	2.50942263660706
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/114	65/9376	3.79595141700405	SPP1/PLCB1/CGA	2.50942263660706
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/114	30/9376	5.48304093567251	PLA2G2A/PLA2G5	2.72838792669973
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/114	71/9376	3.47516679021497	PRLR/SHC2/CGA	2.32252892020258
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/114	120/9376	2.74152046783626	RPS6KA2/SHC2/PLCG2/IRS1	2.13006672771789
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/114	75/9376	3.28982456140351	PLCB1/GNAS/CGA	2.20878627235041
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	6/114	233/9376	2.1179128077705	DSP/ITGA1/PDLIM5/OBSCN/LAMA2/COL4A5	1.91702249028598
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/114	76/9376	3.24653739612188	EZR/PLCB1/GNAS	2.18154738022877
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/114	76/9376	3.24653739612188	PDGFRB/SHC2/PLCG2	2.18154738022877
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/114	78/9376	3.16329284750337	PLCB1/ISYNA1/PLCG2	2.12840132362922
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	7/114	300/9376	1.91906432748538	AREG/IGF2/HGF/RPS6KA2/PDGFRB/FLT1/RAC3	1.79491947222201
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/114	37/9376	4.4457088667615	LEF1/TPR	2.32978009431526
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/114	191/9376	2.15302654542114	H3-3A/H2AJ/H3-3B/GNAS/SHC2	1.78608484197594
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	5/114	193/9376	2.13071538951004	PTK2/PLCB1/SHC2/RAC3/PLCG2	1.76086207982797
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/114	138/9376	2.38393084159675	PRKAR2B/PRKAR1A/SHC2/IRS1	1.8169820113673
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/114	195/9376	2.10886189833558	H3-3A/H2AJ/H3-3B/PLCB1/PLCG2	1.73594295004147
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/114	87/9376	2.83605565638234	AREG/LEF1/RAC3	1.9087395054381
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/114	142/9376	2.31677786014332	PTK2/MGST2/RAC3/PLAT	1.75407205024714
NA	NA	hsa04082	Neuroactive ligand signaling	5/114	199/9376	2.06647271444944	PLCB1/GNAL/P2RY1/GNAS/P2RY14	1.6869864583129
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/114	43/9376	3.82537739698082	PLA2G2A/PLA2G5	2.06008783179764
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/114	201/9376	2.04591079689273	H3-3A/PTK2/H3-3B/FLT1/PLAT	1.66293515298256
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/114	144/9376	2.28460038986355	WNT3A/TBX3/WNT6/WNT2	1.72340390698407
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/114	91/9376	2.71139386928861	CD79B/RAC3/PLCG2	1.81997486249638
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/114	93/9376	2.65308432371251	LEF1/RAC3/TJP1	1.77737055889021
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/114	93/9376	2.65308432371251	PLCB1/GNAS/CGA	1.77737055889021
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/114	154/9376	2.13624971519708	AGTR1/PLCB1/SCN7A/GNAS	1.57727443574879
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/114	99/9376	2.4922913343966	PLCB1/GNAS/PLCG2	1.65597246663667
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/114	105/9376	2.34987468671679	GNAS/ITGA1/LAMA2	1.54315833146154
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/114	53/9376	3.10360807679576	PLCB1/GNAS	1.70376855211924
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/114	106/9376	2.32770605759682	LEF1/PDGFRB/PLAT	1.52510827609301
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	5/114	227/9376	1.81157740165391	COX4I2/HGF/NDUFA4L2/PTK2/MGST2	1.373225109584
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/114	116/9376	2.12704174228675	EZR/PTK2/PLCG2	1.35503083510777
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/114	63/9376	2.61097187412977	PLA2G2A/PLA2G5	1.42330870968098
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/114	122/9376	2.02243313201035	PLCB1/NOTCH3/PLCG2	1.26106002121521
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	7/114	388/9376	1.48381262434437	COX4I2/NDUFA4L2/WNT3A/PLCB1/WNT6/WNT2/IRS1	1.07980964637738
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	5/114	253/9376	1.62540739199778	H3-3A/PTK2/H3-3B/PLCB1/PLCG2	1.11876818798425
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/114	67/9376	2.45509295627128	PLCB1/RPS6KA2	1.32605732889232
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/114	323/9376	1.52778230405736	EZR/WNT3A/NOTCH3/PDGFRB/PLCG2/IRS1	1.07089157347162
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/114	128/9376	1.92763157894737	PDE8B/GUCY1A2/GUCY1B1	1.17230947343699
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/114	69/9376	2.38393084159675	RAC3/PLCG2	1.28002883152195
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/114	70/9376	2.34987468671679	RAC3/LAMA2	1.25761186137873
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/114	71/9376	2.31677786014332	TJP1/PLCG2	1.23557518376356
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/114	133/9376	1.85516422635536	SHC2/RAC3/PLCG2	1.10193136402637
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/114	133/9376	1.85516422635536	PLCB1/GNAL/GNAS	1.10193136402637
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/114	73/9376	2.25330449411199	HGF/PDGFRB	1.19259282478088
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/114	73/9376	2.25330449411199	HGF/PLCG2	1.19259282478088
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/114	138/9376	1.78794813119756	PTK2/RPS6KA2/RAC3	1.03450803843969
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/114	139/9376	1.77508519500189	PLCB1/GNAS/SHC2	1.02135576667528
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/114	77/9376	2.13624971519708	ARHGEF6/RAC3	1.1106742458878
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/114	78/9376	2.10886189833558	PTK2/SHC2	1.09097718085798
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/114	23/9376	3.57589626239512	AGTR1	1.37215286051262
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/114	23/9376	3.57589626239512	SLC4A4	1.37215286051262
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/114	86/9376	1.91268869849041	PLCB1/P2RY1	0.94329974493866
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/114	86/9376	1.91268869849041	PLCB1/GNAS	0.94329974493866
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/114	28/9376	2.93734335839599	MOCS1	1.13896908862799
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/114	226/9376	1.45567458469182	PPP1R12A/GNAS/RAC3/CGA	0.769279491373983
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	4/114	227/9376	1.44926192132313	PTK2/PLCB1/GNAS/RAC3	0.76017118007921
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/114	157/9376	1.57157224270868	PTK2/GAS6/C1QA	0.80124387792949
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/114	157/9376	1.57157224270868	COX4I2/NDUFA4L2/IRS1	0.80124387792949
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/114	90/9376	1.82768031189084	SLC4A4/GNAS	0.875296547222747
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/114	91/9376	1.80759591285907	PDE8B/GNAS	0.858834594907891
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/114	160/9376	1.54210526315789	PTPRD/CADM1/NTNG1	0.767287384243779
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	4/114	235/9376	1.39992534527809	COX4I2/NDUFA4L2/GNAS/RPS6KA2	0.688813548217753
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/114	32/9376	2.57017543859649	SEPTIN4	0.987057447003286
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/114	33/9376	2.4922913343966	VAMP8	0.952693249918835
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/114	168/9376	1.46867167919799	PRLR/PDGFRB/CSH1	0.680027337483603
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/114	98/9376	1.67848191908342	MYO10/PLCG2	0.749048274464747
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/114	99/9376	1.6615275562644	ITGA1/LAMA2	0.734086832674824
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/114	36/9376	2.28460038986355	DCXR	0.856705464955299
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/114	103/9376	1.59700221427355	DPP4/COL4A5	0.675880785173701
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/114	37/9376	2.22285443338075	PLCB1	0.826820264653785
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/114	38/9376	2.16435826408126	IRS1	0.797879246751895
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/114	107/9376	1.53730119691753	PLCB1/GNAS	0.620124559185866
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/114	109/9376	1.5090938355062	RPS6KA2/IRS1	0.593098985679375
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/114	110/9376	1.49537480063796	FLT1/PLCG2	0.57978874536813
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/114	110/9376	1.49537480063796	PITX2/BMP5	0.57978874536813
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/114	41/9376	2.00599058622165	GATM	0.716167089131256
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/114	112/9376	1.46867167919799	LAMC3/LAMA2	0.553559265662457
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/114	115/9376	1.43035850495805	PLCB1/GNAS	0.515152775165833
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/114	115/9376	1.43035850495805	PLCB1/GNAS	0.515152775165833
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	4/114	268/9376	1.22754647813564	COX4I2/NDUFA4L2/GNAL/GNAS	0.419287272595392
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/114	116/9376	1.41802782819117	PLCB1/GNAS	0.50259061033788
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/114	44/9376	1.86921850079745	GNAS	0.6411410884565
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	4/114	275/9376	1.19629984051037	COX4I2/NDUFA4L2/C7/C1QA	0.366545094777982
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/114	47/9376	1.74990668159761	IRS1	0.57177383951051
NA	NA	hsa03272	Virion - Hepatitis viruses	1/114	48/9376	1.71345029239766	DPP4	0.549763301380237
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/114	48/9376	1.71345029239766	PLCB1	0.549763301380237
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/114	125/9376	1.3159298245614	PLCB1/RAC3	0.394490880380972
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/114	49/9376	1.67848191908342	GNAS	0.528263988163538
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/114	50/9376	1.64491228070175	GATM	0.507251826131335
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/114	50/9376	1.64491228070175	HGF	0.507251826131335
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/114	52/9376	1.58164642375169	LIPG	0.466600583022459
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/114	54/9376	1.5230669265757	CGA	0.427646839441701
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/114	214/9376	1.15297589768815	PTK2/RAC3/PLCG2	0.25114262476726
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/114	298/9376	1.10396797362534	PRLR/BMP5/ACKR3/CSH1	0.202347711904883
NA	NA	hsa04382	Cornified envelope formation	3/114	217/9376	1.13703613873393	DSP/TJP1/COL4A5	0.22658263653223
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/114	217/9376	1.13703613873393	GNAS/RPS6KA2/MGST2	0.22658263653223
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/114	138/9376	1.19196542079837	COX4I2/NDUFA4L2	0.252034065512091
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/114	59/9376	1.39399345822183	MGST2	0.336792680613233
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/114	59/9376	1.39399345822183	LEF1	0.336792680613233
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/114	144/9376	1.14230019493177	C1QA/LEF1	0.190908171790344
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/114	61/9376	1.34828875467357	MT1E	0.302760083183751
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	6/114	480/9376	1.0280701754386	COX4I2/NDUFA4L2/WNT3A/PLCB1/WNT6/WNT2	0.0700412735333256
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/114	62/9376	1.32654216185625	IRS1	0.286188822075062
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/114	62/9376	1.32654216185625	NOTCH3	0.286188822075062
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/114	63/9376	1.30548593706488	PRDM6	0.269899680988771
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/114	149/9376	1.10396797362534	NDUFA4L2/PLCB1	0.141921479172382
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/114	66/9376	1.2461456671983	HSD17B2	0.222625546351668
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/114	68/9376	1.20949432404541	LEF1	0.192346463371546
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/114	69/9376	1.19196542079837	GNAS	0.17755314491991
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/114	70/9376	1.1749373433584	IRS1	0.162980519725651
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/114	70/9376	1.1749373433584	MGST2	0.162980519725651
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/114	70/9376	1.1749373433584	HGF	0.162980519725651
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/114	71/9376	1.15838893007166	PDGFRB	0.148621447324534
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/114	73/9376	1.126652247056	MGST2	0.120517050557914
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/114	75/9376	1.0966081871345	MGST2	0.0931891644172766
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/114	77/9376	1.06812485759854	SHC2	0.0665914576940952
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/114	169/9376	0.973320876154884	VAMP8/IRS1	-0.0388276869382257
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/114	170/9376	0.967595459236326	EZR/TJP1	-0.0473021109013836
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/114	78/9376	1.05443094916779	C1QA	0.0535530380867407
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/114	79/9376	1.04108372196314	MGST2	0.0406815589558261
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/114	82/9376	1.00299529311083	MGST2	0.00302225145462289
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/114	87/9376	0.945351885460778	COX4I2	-0.0568114668834406
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	2/114	187/9376	0.879632235669387	TXNIP/PLCB1	-0.184451651137205
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/114	90/9376	0.913840155945419	IRS1	-0.0911165977090095
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/114	93/9376	0.884361441237502	NOTCH3	-0.124332780166575
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/114	194/9376	0.847892928196781	MYO1B/MYO10	-0.237502016945428
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/114	95/9376	0.865743305632502	FLT1	-0.145910330691297
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	2/114	196/9376	0.839240959541711	LEF1/PLCG2	-0.252329354046361
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/114	99/9376	0.830763778132199	C1QA	-0.187798801287023
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/114	100/9376	0.822456140350877	ACKR3	-0.198020869154277
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/114	100/9376	0.822456140350877	ITGA1	-0.198020869154277
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/114	105/9376	0.783291562238931	PLCG2	-0.247738130450009
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/114	105/9376	0.783291562238931	PLCG2	-0.247738130450009
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	3/114	308/9376	0.801093643198906	COX4I2/NDUFA4L2/PLCB1	-0.39378025957557
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/114	108/9376	0.761533463287849	TPR	-0.276523461776363
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/114	109/9376	0.754546917753098	SPP1	-0.285955091103713
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/114	110/9376	0.747687400318979	RPS6KA2	-0.295307725425751
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	2/114	216/9376	0.761533463287849	PTK2/PLCB1	-0.39336186893582
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/114	115/9376	0.715179252479024	PLCB1	-0.34093946516647
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/114	117/9376	0.702953966111861	H2AJ	-0.358690870046612
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/114	122/9376	0.674144377336785	IRS1	-0.40190745542527
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/114	122/9376	0.674144377336785	NCK2	-0.40190745542527
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/114	133/9376	0.618388075451787	IRS1	-0.491730284764507
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/114	136/9376	0.604747162022704	RACK1	-0.515103073274427
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/114	137/9376	0.600332949161224	SEPTIN4	-0.522795476761846
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/114	138/9376	0.595982710399186	RPS6KA2	-0.530439907415513
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/114	142/9376	0.579194465035829	UBA2	-0.560552580516209
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/114	142/9376	0.579194465035829	PLCG2	-0.560552580516209
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/114	144/9376	0.571150097465887	PLCB1	-0.575339695806516
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	3/114	368/9376	0.670480549199085	COX4I2/NDUFA4L2/TPR	-0.715445326767935
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/114	154/9376	0.534062428799271	MOCS1	-0.646786890135608
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/114	168/9376	0.489557226399332	H2AJ	-0.740635834585528
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	1/114	205/9376	0.40119811724433	PLCG2	-0.961695129408225
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	1/114	224/9376	0.367167919799499	MSX1	-1.06350654201417
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	1/114	248/9376	0.331635540464063	LEF1	-1.18341494173225
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/114	250/9376	0.328982456140351	VAMP8	-1.19302439072528
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/114	449/9376	0.183175086937835	GNAL	-1.96781856655998