category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	94/1010	222/9376	3.93071090892873	RPS4Y1/RPS10/RPL36A/RPLP0/RPL4/RPL18A/RPL13A/RPS2/RPL17/RPL26/RPS9/RPL27A/RPS17/RPL23A/RACK1/RPS16/RPS18/RPL31/RPS5/RPS3/RPL7A/RPL13/RPS14/RPS20/RPL10A/RPL27/MRPS18B/RPS25/RPS6/RPL3/RPL29/RPS3A/MRPL38/RPL18/RPL23/RPSA/RPL14/RPS12/MRPL46/RPLP2/MRPS2/RPL19/MRPS12/MRPS28/MRPL15/RPS23/MRPL12/RPL9/MRPS17/RPS13/RPS8/RPS19/RPL8/MRPS26/RPL35/MRPL4/MRPS24/RPL15/RPS11/MRPS25/MRPL11/RPL6/MRPL23/MRPL2/RPL32/RPL7/RPLP1/MRPS34/RPS7/MRPL27/MRPL45/RPS15A/RPL24/MRPL18/MRPL40/RPL12/MRPS35/RPL21/MRPL17/MRPS16/RPS24/MRPL3/MRPL14/MRPS7/MRPL21/MRPL44/MRPL37/RPL22/RPL38/RPS15/MRPL50/MRPL24/MRPL30/MRPL35	15.3543490447919
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	78/1010	238/9376	3.04238289375156	RPS4Y1/RPS10/RPL36A/RPLP0/RPL4/RPL18A/RPL13A/RPS2/RPL17/RPL26/RPS9/C1QA/F13A1/RPL27A/RPS17/RPL23A/RPS16/C1QB/C1QC/RPS18/RPL31/RPS5/RPS3/RPL7A/RPL13/RPS14/RPS20/FCGR2A/RPL10A/RPL27/RPS25/RPS6/RPL3/RPL29/RPS3A/RPL18/RPL23/RPSA/RPL14/RPS12/RPLP2/NRP1/RPL19/RPS23/RPL9/RPS13/C2/RPS8/RPS19/RPL8/RPL35/TNF/RPL15/RPS11/RPL6/RPL32/RPL7/IL1B/NFKBIB/RPLP1/RPS7/RPS15A/RPL24/CYBB/RPL12/TLR4/RPL21/C3AR1/CFD/TLR7/RPS24/RPL22/PIK3R2/RPL38/RPS15/PLCG2/CXCL8/HBEGF	11.0888743122943
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	76/1010	275/9376	2.5655301530153	SLC25A6/PPIF/ATP5F1A/TUBB/C1QA/C1QB/TUBA1B/C1QC/ATP5F1B/PSMC4/NDUFA7/NDUFS3/HSPA1A/PSMB3/NDUFA3/NDUFA6/SLC25A5/PSMA2/HSPA1B/NDUFS1/CSNK2B/PSMB5/TUBA1C/PSMA6/NCF4/ATP5PO/STIP1/NDUFA13/TNF/CYC1/ATF6B/SDHD/PSMB4/PSMD11/IL1B/NDUFA11/NDUFV3/PRKACA/SOD1/PSMD3/PSMC1/ATP5MC2/UQCR10/ATP5PB/NDUFB9/CYBB/ADRM1/UQCRC1/NDUFA10/SDHC/ATP5MC3/PSMB6/TUBB4B/NDUFS2/UQCRH/NDUFA8/UQCRC2/PSMD6/COX4I2/CCL5/ATF4/PSMD4/SDHA/PSMB2/NDUFC1/PIK3R2/PSMD13/PSMC2/PSMC5/PSMA3/NDUFC2/NDUFV1/COX5B/HSPA8/COX8A/PSMA1	9.15525871756195
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	74/1010	268/9376	2.56326289345352	SLC25A6/PPIF/ATP5F1A/TUBB/GNAS/TUBA1B/ATP5F1B/PSMC4/NDUFA7/TXN2/NDUFS3/PSMB3/NDUFA3/NDUFA6/SLC25A5/SLC39A1/PSMA2/NDUFS1/PSMB5/TUBA1C/TRAP1/PSMA6/ATP5PO/SNCA/NDUFA13/SLC39A7/CYC1/SDHD/DAXX/PSMB4/PSMD11/NDUFA11/NDUFV3/PRKACA/SOD1/PSMD3/PSMC1/SLC39A3/ATP5MC2/UQCR10/ATP5PB/NDUFB9/ADRM1/UQCRC1/TP53/NDUFA10/SDHC/ATP5MC3/PSMB6/TUBB4B/SLC39A4/NDUFS2/UQCRH/NDUFA8/UQCRC2/PSMD6/COX4I2/ATF4/PSMD4/SDHA/PSMB2/NDUFC1/PSMD13/PSMC2/PSMC5/UBE2G2/PSMA3/SLC11A2/NDUFC2/NDUFV1/COX5B/COX8A/PSMA1/HTRA2	9.02142826957931
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	75/1010	308/9376	2.26051176546226	SLC25A6/PPIF/ATP5F1A/CLTA/TUBB/TUBA1B/ATP5F1B/PSMC4/NDUFA7/GPX3/NDUFS3/PSMB3/NDUFA3/NDUFA6/SLC25A5/PSMA2/NDUFS1/PSMB5/TUBA1C/PSMA6/ATP5PO/NDUFA13/AP2M1/CYC1/PPARG/SDHD/AP2A2/TFAM/PSMB4/POLR2E/PSMD11/NDUFA11/NDUFV3/POLR2J3/SOD1/PSMD3/PSMC1/ATP5MC2/POLR2A/UQCR10/ATP5PB/NDUFB9/ADRM1/UQCRC1/TP53/NDUFA10/SDHC/ATP5MC3/PSMB6/TUBB4B/NDUFS2/UQCRH/NDUFA8/UQCRC2/PSMD6/COX4I2/HDAC2/SOD2/CLTC/PSMD4/SDHA/PSMB2/NDUFC1/PSMD13/PSMC2/DNAH14/AP2S1/PSMC5/PSMA3/NDUFC2/NDUFV1/WIPI2/COX5B/COX8A/PSMA1	7.81544841960805
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	31/1010	82/9376	3.50949046124125	HSP90AB1/HLA-DRB1/CTSB/CANX/HLA-DRA/HSP90AA1/LGMN/HSPA1A/PSME2/HSPA1B/HLA-E/IFI30/HLA-C/CD4/HLA-A/PSME1/TNF/HLA-DPA1/CTSL/HLA-B/TAPBP/HSPA4/HLA-DMA/HLA-G/HLA-DPB1/HLA-DRB5/TAP1/HLA-DMB/CTSS/HLA-F/HSPA8	7.93009767080291
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	42/1010	138/9376	2.82531209642703	ATP5F1A/ATP5F1B/NDUFA7/NDUFS3/ATP6V0C/NDUFA3/NDUFA6/NDUFS1/ATP5PO/NDUFA13/ATP6V1B2/CYC1/SDHD/ATP6V1C2/NDUFA11/NDUFV3/PPA2/ATP5MC2/UQCR10/ATP5PB/NDUFB9/PPA1/UQCRC1/NDUFA10/SDHC/ATP5MC3/NDUFS2/UQCRH/NDUFA8/UQCRC2/COX4I2/COX15/ATP5MF/SDHA/NDUFC1/ATP5MG/NDUFC2/NDUFV1/ATP6V0D1/COX5B/COX8A/ATP6V0A1	7.50542157135409
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	22/1010	46/9376	4.4397761515282	PSMC4/PSMB3/PSMA2/PSME2/PSMB5/PSMA6/PSME1/PSMB4/PSMD11/PSMD3/PSMC1/ADRM1/PSMB8/PSMB6/PSMD6/PSMD4/PSMB2/PSMD13/PSMC2/PSMC5/PSMA3/PSMA1	8.125604315137
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	79/1010	368/9376	1.9928540680155	ATP5F1A/TUBB/HNRNPA1/TUBA1B/CHCHD10/ATP5F1B/PSMC4/NDUFA7/GPX3/NDUFS3/PSMB3/NDUFA3/NDUFA6/PSMA2/CAT/NDUFS1/PSMB5/TUBA1C/PSMA6/ATP5PO/NDUFA13/TNF/CYC1/NUP62/SDHD/DAXX/PSMB4/PSMD11/NDUFA11/NDUFV3/VCP/SOD1/PSMD3/PSMC1/ATP5MC2/UQCR10/ATP5PB/NDUFB9/NEFH/SMCR8/ADRM1/UQCRC1/TP53/NDUFA10/SDHC/ATP5MC3/PSMB6/TUBB4B/NDUFS2/UQCRH/NDUFA8/UQCRC2/TOMM40/PSMD6/COX4I2/SRSF3/ANG/HNRNPA1L3/SQSTM1/ATF4/PSMD4/SDHA/NUP160/MAP2K3/PSMB2/NDUFC1/HNRNPA2B1/PSMD13/PSMC2/DNAH14/PFN1/PSMC5/PSMA3/NDUFC2/NDUFV1/WIPI2/COX5B/COX8A/PSMA1	6.7512242700863
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	42/1010	155/9376	2.51543915681891	COLEC12/HLA-DRB1/CD14/CANX/TUBB/TUBA1B/HLA-DRA/FCGR2A/ATP6V0C/MRC1/HLA-E/TUBA1C/NCF4/HLA-C/HLA-A/ATP6V1B2/OLR1/SCARB1/RILP/HLA-DPA1/CTSL/ATP6V1C2/CD36/HLA-B/FCGR1A/CYBB/TLR4/TUBB4B/HLA-DMA/HLA-G/HLA-DPB1/CD209/ITGB2/HLA-DRB5/TAP1/HLA-DMB/CTSS/RAB5C/HLA-F/ATP6V0D1/MSR1/ATP6V0A1	6.61001945396254
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	54/1010	227/9376	2.20833078902604	SLC25A6/PPIF/ATP5F1A/ATP5F1B/NDUFA7/NDUFS3/NDUFA3/NDUFA6/SLC25A5/CAT/NDUFS1/HMOX1/ATP5PO/GSTT1/NDUFA13/CYC1/SDHD/GSTO1/NDUFA11/NDUFV3/GSTA3/GSTA4/GSTM3/GSTM5/PTEN/SOD1/ATP5MC2/UQCR10/ATP5PB/NDUFB9/UQCRC1/NDUFA10/SDHC/ATP5MC3/AKR1A1/NDUFS2/HRAS/UQCRH/NDUFA8/UQCRC2/COX4I2/AKT1/MGST3/SOD2/SDHA/NDUFC1/PIK3R2/EPHX2/EPHX1/MGST2/NDUFC2/NDUFV1/COX5B/COX8A	6.40323368304794
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	41/1010	154/9376	2.47149286357207	QPRT/NME4/NAPRT/AK6/HMBS/NME1/NMNAT3/UROD/ADSL/SHMT1/FECH/BCAT2/AK1/MTHFD1/BCAT1/AKR1A1/CPOX/NME2/AFMID/COASY/ALAD/PDXP/ALDH3A2/RDH13/COX15/FLAD1/PNPO/SHMT2/AK3/ALDH1B1/DHODH/GCLM/AK2/ALAS1/ALAS2/NADK/MOCS1/CAD/RFK/DHFR/UMPS	6.39725049611552
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	78/1010	388/9376	1.86620393998163	SLC25A6/PPIF/ATP5F1A/TUBB/TUBA1B/ATP5F1B/PSMC4/NDUFA7/NDUFS3/PSMB3/NDUFA3/NDUFA6/SLC25A5/SLC39A1/PSMA2/NDUFS1/CSNK2B/PSMB5/TUBA1C/PSMA6/ATP5PO/SNCA/NDUFA13/TNF/SLC39A7/CYC1/SDHD/PSMB4/PSMD11/IL1B/NDUFA11/NDUFV3/WNT5B/PSMD3/PSMC1/SLC39A3/ATP5MC2/UQCR10/ATP5PB/NDUFB9/CYBB/ADRM1/UQCRC1/NDUFA10/SDHC/ATP5MC3/PSMB6/TUBB4B/SLC39A4/NDUFS2/HRAS/UQCRH/NDUFA8/UQCRC2/PSMD6/COX4I2/AKT1/CSNK1E/ATF4/PSMD4/SDHA/APOE/PSMB2/NDUFC1/FZD5/PIK3R2/PSMD13/PSMC2/PSMC5/PSMA3/SLC11A2/NDUFC2/NDUFV1/WIPI2/COX5B/COX8A/PSMA1/FZD3	6.05468956120434
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	48/1010	205/9376	2.17361989857522	SLC25A6/PPIF/ATP5F1A/PARP1/ATP5F1B/NDUFA7/NDUFS3/NDUFA3/NDUFA6/SLC25A5/NDUFS1/CPT2/NCF4/ATP5PO/PDK4/NDUFA13/CYC1/SDHD/CD36/NDUFA11/NDUFV3/PTEN/ATP5MC2/UQCR10/ATP5PB/NDUFB9/CYBB/PDHA1/UQCRC1/NDUFA10/SDHC/PPP1CC/ATP5MC3/NDUFS2/UQCRH/NDUFA8/UQCRC2/COX4I2/AKT1/SDHA/NDUFC1/PIK3R2/MPC2/NDUFC2/NDUFV1/COX5B/COX8A/PTPA	5.9031448922679
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	39/1010	157/9376	2.30600996405373	NDUFA7/NDUFS3/NDUFA3/NDUFA6/ADIPOR2/NDUFS1/CEBPA/NDUFA13/TNF/CYC1/PPARG/MLXIP/SDHD/IL1B/NDUFA11/NDUFV3/UQCR10/NDUFB9/UQCRC1/NDUFA10/SDHC/NDUFS2/UQCRH/NDUFA8/UQCRC2/COX4I2/AKT1/PKLR/ATF4/SDHA/NDUFC1/PIK3R2/CDC42/PRKAG1/CXCL8/NDUFC2/NDUFV1/COX5B/COX8A	5.73379027945159
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	28/1010	95/9376	2.7360917144346	HLA-DRB1/FLT1/HLA-DRA/CCL3/ATP6V0C/ATP6V1B2/TNF/HLA-DPA1/CTSL/ATP6V1C2/CCL3L1/ANGPT1/IL1B/CXCL3/TLR4/HLA-DMA/HLA-DPB1/ITGB2/HLA-DRB5/CD86/CCL5/CXCL2/HLA-DMB/CXCL1/CXCL8/ATP6V0D1/ATP6V0A1/TNFSF13	5.90914266987745
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	51/1010	235/9376	2.01464503897198	ATP5F1A/GNAS/ATP5F1B/NDUFA7/RPS6/NDUFS3/NDUFA3/NDUFA6/SMARCB1/NDUFS1/CPT2/ATP5PO/NDUFA13/COA7/CYC1/PPARG/SDHD/NDUFA11/NDUFV3/PRKACA/RPS6KA1/ATP5MC2/UQCR10/ATP5PB/NDUFB9/COA4/UQCRC1/NDUFA10/SDHC/ATP5MC3/NDUFS2/HRAS/UQCRH/NDUFA8/UQCRC2/COX4I2/COX15/ATP5MF/SDHA/MAP2K3/NDUFC1/KDM1A/ATP5MG/NDUFAF4/MLST8/PRKAG1/NDUFC2/NDUFV1/COX5B/COX8A/COX16	5.47316584234754
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	14/1010	30/9376	4.33214521452145	FOLR2/TNF/TYMS/ATIC/SHMT1/SLC19A1/IL1B/FOLR1/GART/SHMT2/SLC46A1/ABCG2/MTHFR/DHFR	6.35124774375099
Human Diseases	Immune disease	hsa05330	Allograft rejection	16/1010	39/9376	3.80847930946941	HLA-DRB1/HLA-DRA/HLA-E/HLA-C/HLA-A/TNF/HLA-DPA1/HLA-B/CD40LG/HLA-DMA/HLA-G/HLA-DPB1/HLA-DRB5/CD86/HLA-DMB/HLA-F	6.10642809871962
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	17/1010	44/9376	3.58667866786679	HSPD1/HLA-DRB1/HLA-DRA/HLA-E/HLA-C/HLA-A/TNF/HLA-DPA1/IL1B/HLA-B/HLA-DMA/HLA-G/HLA-DPB1/HLA-DRB5/CD86/HLA-DMB/HLA-F	5.97542568648521
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	84/1010	480/9376	1.62455445544554	SLC25A6/PPIF/ATP5F1A/TUBB/TUBA1B/ATP5F1B/PSMC4/NDUFA7/GPX3/NDUFS3/PSMB3/NDUFA3/NDUFA6/SLC25A5/PSMA2/CAT/NDUFS1/CSNK2B/PSMB5/TUBA1C/TRAP1/PSMA6/ATP5PO/SNCA/NDUFA13/TNF/CYC1/SDHD/DAXX/PSMB4/PSMD11/IL1B/NDUFA11/NDUFV3/WNT5B/VCP/SOD1/PSMD3/PSMC1/ATP5MC2/UQCR10/ATP5PB/NDUFB9/NEFH/CYBB/SMCR8/ADRM1/UQCRC1/NDUFA10/SDHC/ATP5MC3/PSMB6/TUBB4B/NDUFS2/HRAS/UQCRH/NDUFA8/UQCRC2/TOMM40/PSMD6/COX4I2/CSNK1E/SQSTM1/ATF4/PSMD4/SDHA/MAP2K3/PSMB2/NDUFC1/FZD5/PSMD13/PSMC2/DNAH14/PSMC5/UBE2G2/PSMA3/NDUFC2/NDUFV1/WIPI2/COX5B/COX8A/PSMA1/FZD3/HTRA2	4.88068677866114
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	17/1010	47/9376	3.35774173161997	LDHB/ACSS1/LDHA/ALDH7A1/ADH5/MDH2/PCK2/PDHA1/AKR1A1/FH/MDH1/PKLR/ALDH3A2/ACACA/ALDH1B1/ME2/DLAT	5.63008572922709
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	18/1010	54/9376	3.09438943894389	LDHB/CDO1/DNMT1/LDHA/AHCY/SRM/PHGDH/MDH2/BCAT2/ADI1/AHCYL1/BCAT1/MPST/SMS/MDH1/CISD1/GCLM/DNMT3A	5.36274522488796
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/1010	45/9376	3.30068206820682	HLA-DRB1/HLA-DRA/HLA-E/HLA-C/HLA-A/TNF/HLA-DPA1/IL1B/HLA-B/HLA-DMA/HLA-G/HLA-DPB1/HLA-DRB5/CD86/HLA-DMB/HLA-F	5.37509525098789
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	46/1010	224/9376	1.90636492220651	SLC25A6/HLA-DRB1/CCNE1/CANX/MSX2/GPS2/HLA-DRA/SLC25A5/MAD1L1/MYC/HLA-E/RAN/NRP1/CDC20/HLA-C/CD4/HLA-A/SPI1/TNF/HLA-DPA1/ATF6B/CDK4/RANBP1/PRKACA/PTEN/HLA-B/CCNA2/KAT2A/TP53/HLA-DMA/E2F2/CCNB2/HRAS/HLA-G/HLA-DPB1/AKT1/ITGB2/HLA-DRB5/ATF4/PTTG1/HLA-DMB/PIK3R2/HLA-F/STAT5A/ETS2/XPO1	4.77041857828472
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/1010	56/9376	2.98387553041018	HSPD1/CD14/EEF1A1/EEF1G/HSPA1A/HSPA1B/HSF1/TNF/IL1B/VCP/CXCL3/TLR4/ITGB2/CXCL2/CXCL1/NAIP/CXCL8/HSPA8	5.17354073633565
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	28/1010	116/9376	2.24076476613179	ACSS1/GCSH/IDH1/CAT/RPIA/TKT/PHGDH/ADH5/SDHD/SHMT1/IDH2/ECHS1/MDH2/AMT/PCCB/PDHA1/SDHC/FH/MDH1/PKLR/TALDO1/SHMT2/SDHA/PGAM1/MCEE/ESD/ME2/DLAT	4.67197326189466
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	14/1010	39/9376	3.33241939578573	MTHFS/ALDH7A1/GCSH/AHCY/TYMS/ATIC/SHMT1/AMT/MTHFD1/AHCYL1/GART/SHMT2/MTHFR/DHFR	5.07133924341264
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/1010	30/9376	3.71326732673267	IDH1/SDHD/IDH2/MDH2/PCK2/PDHA1/SDHC/FH/MDH1/SDHA/ACLY/DLAT	5.1716332505572
NA	NA	hsa04981	Folate transport and metabolism	12/1010	31/9376	3.5934845097413	MTHFS/FOLR2/TYMS/SHMT1/SLC19A1/MTHFD1/FOLR1/SHMT2/SLC46A1/ABCG2/MTHFR/DHFR	5.02530294003191
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	41/1010	205/9376	1.85663366336634	HLA-DRB1/CCNE1/PSMC4/HLA-DRA/MYC/HLA-E/SKP2/HLA-C/HLA-A/TNF/HLA-DPA1/CDK4/PSMD11/NFKBIB/NFKBIE/HLA-B/PSMD3/PSMC1/TAPBP/CCNA2/ADRM1/TP53/HLA-DMA/E2F2/HLA-G/HLA-DPB1/PSMD6/AKT1/HDAC2/HLA-DRB5/TAP1/PSMD4/HLA-DMB/MAP2K3/PIK3R2/HLA-F/PSMD13/PSMC2/PSMC5/PLCG2/RBPJ	4.30874820764775
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	17/1010	59/9376	2.67481120993455	GPX3/IDH1/GSTT1/SRM/IDH2/GSTO1/GSTA3/GSTA4/GSTM3/GSTM5/TXNDC12/LAP3/SMS/MGST3/MGST2/GCLM/GGCT	4.48374816676121
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	16/1010	54/9376	2.75056839017235	HLA-DRB1/HLA-DRA/HLA-E/HLA-C/HLA-A/HLA-DPA1/HLA-B/CD40LG/CGA/HLA-DMA/HLA-G/HLA-DPB1/HLA-DRB5/CD86/HLA-DMB/HLA-F	4.48238140465913
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	40/1010	205/9376	1.81134991547935	CCNE1/YWHAE/MRPS18B/MAD1L1/HLA-E/GTF2H1/ACTN4/CDC20/SKP2/HLA-C/HLA-A/DDB1/ATF6B/DNAJA3/YWHAH/CDK4/RANBP1/PRKACA/HLA-B/PSMC1/CCNA2/CDK1/PMAIP1/KAT2A/TP53/HRAS/HLA-G/SCRIB/CHD4/HDAC2/GTF2H4/ATF4/HNRNPK/PIK3R2/HLA-F/CDC42/STAT5A/HDAC7/ATP6V0D1/RBPJ	4.08097725270201
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	15/1010	50/9376	2.7849504950495	ALDH7A1/GATM/CKMT1B/CNDP2/SRM/CKMT1A/AOC1/ARG2/LAP3/SMS/PYCR2/ALDH3A2/ALDH1B1/OAT/GAMT	4.39694331929059
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	11/1010	31/9376	3.29402746726286	ACSS1/GCSH/CAT/SHMT1/MDH2/AMT/PCCB/AFMID/MDH1/SHMT2/MCEE	4.4450556509782
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	12/1010	36/9376	3.09438943894389	SSBP1/MCM2/MCM3/MCM7/POLD4/MCM5/POLD1/MCM4/RNASEH1/PCNA/LIG1/MCM6	4.37444183715733
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	18/1010	70/9376	2.38710042432815	HLA-DRB1/HLA-DRA/HLA-E/HLA-C/HLA-A/HLA-DPA1/HLA-B/CD40LG/HLA-DMA/HLA-G/HLA-DPB1/RAC3/ITGB2/HLA-DRB5/CD86/SSPN/HLA-DMB/HLA-F	4.04727575563206
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	45/1010	250/9376	1.6709702970297	CTSB/CLTA/SLC29A1/LGMN/ATP6V0C/NEU1/CLN6/ATP6V1B2/CLN8/AP2M1/CTSL/ATP6V1C2/AP2A2/MAN2B1/VAMP8/CD68/LAMTOR1/LAPTM4B/HEXA/HEXB/TLR7/AP3S2/TFEB/PPT2/FUCA1/CLTC/SLC15A3/CTSS/CLN3/RRAGA/AP1B1/BORCS5/AP2S1/MLST8/TPCN1/SLC29A2/HYAL3/KXD1/SLC11A2/PSAP/ATP6V0D1/ATP6V0A1/DEPTOR/CTSZ/VPS11	3.73611694776388
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/1010	78/9376	2.26128458999746	HLA-DRB1/EEF1A1/HLA-DRA/FCGR2A/MARCKSL1/NCF4/TNF/HLA-DPA1/IFNGR2/IL1B/NFKBIB/FCGR1A/CYBB/TLR4/HLA-DMA/HLA-DPB1/ITGB2/HLA-DRB5/HLA-DMB	3.88644937613447
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	31/1010	158/9376	1.82138112545432	CCNE1/YWHAE/MAD1L1/E2F5/MYC/CDC20/SKP2/CCNB1/E2F4/MCM2/YWHAH/CDK4/SKP1/MCM3/CCNA2/MCM7/PPP2CA/CDK1/CDT1/TP53/MCM5/E2F2/CCNB2/HDAC2/MCM4/PTTG1/CDK7/PCNA/ORC6/MCM6/MAD2L1BP	3.6177812659695
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	13/1010	48/9376	2.51419141914191	ALDH7A1/ECHS1/BCAT2/PCCB/BCAT1/BCKDHA/HIBADH/ALDH3A2/HADH/HADHB/ALDH1B1/MCEE/HADHA	3.65421861543791
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	28/1010	144/9376	1.80506050605061	SLC25A6/PPIF/PSMC4/PSMB3/SLC25A5/PSMA2/PSMB5/PSMA6/PSMB4/PSMD11/PSMD3/PSMC1/ADRM1/PSMB6/PSMD6/AKT1/PSMD4/NOP56/PSMB2/PIK3R2/PSMD13/PSMC2/PSMC5/PSMA3/WIPI2/PSMA1/TWNK/RBPJ	3.38258925552564
Human Diseases	Immune disease	hsa05310	Asthma	10/1010	32/9376	2.9009900990099	HLA-DRB1/HLA-DRA/PRG2/TNF/HLA-DPA1/CD40LG/HLA-DMA/HLA-DPB1/HLA-DRB5/HLA-DMB	3.74262077645304
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/1010	43/9376	2.59065162330187	ALDH7A1/CPT2/ECI1/ADH5/ECHS1/ALDH3A2/HADH/HADHB/ALDH1B1/ECI2/HADHA/ACADVL	3.63233640020659
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	29/1010	157/9376	1.71472535788611	SLC25A6/CCNE1/SLC25A5/E2F5/MYC/HLA-E/HLA-C/HLA-A/CCNB1/E2F4/RAD50/CDK4/PTEN/HLA-B/CCNA2/CDK1/TP53/PPP1CC/E2F2/CCNB2/HRAS/HLA-G/AKT1/SQSTM1/MAP2K3/EIF4EBP1/PIK3R2/HLA-F/CXCL8	3.13786680218339
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	12/1010	46/9376	2.42169608265174	HMBS/HMOX1/UROD/HMOX2/FXN/FECH/BLVRB/CPOX/ALAD/COX15/ALAS1/ALAS2	3.3583987198923
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	32/1010	180/9376	1.65034103410341	HLA-DRB1/HLA-DRA/SRSF1/HLA-E/HLA-C/HLA-A/TNF/HLA-DPA1/DAXX/IFNGR2/IL1B/CARD9/HLA-B/TAPBP/SRSF6/TP53/PPP1CC/HLA-DMA/HLA-G/HLA-DPB1/AKT1/SRSF3/TNFRSF14/HLA-DRB5/TAP1/POU2F2/CCL5/HLA-DMB/EIF4EBP1/PIK3R2/HLA-F/EIF2B5	3.06101405322123
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/1010	41/9376	2.49060613378411	ALDH7A1/GCSH/GATM/PHGDH/SHMT1/AMT/SHMT2/PGAM1/GAMT/ALAS1/ALAS2	3.3234187534964
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/1010	85/9376	1.96584740827024	NME4/IMPDH2/PNP/AK6/NME1/ADSL/TYMS/TK1/AK1/DUT/NME2/NTPCR/GMPR2/AK3/ENTPD6/AK2/NT5M/DTYMK	3.1079508817265
Genetic Information Processing	Transcription	hsa03040	Spliceosome	40/1010	243/9376	1.52809355009575	DDX39B/HNRNPA1/PRPF8/SRSF1/CWC25/HSPA1A/PRPF19/HSPA1B/PUF60/SNRPE/RBMX/LSM2/PRPF31/DHX16/SNRPD1/SNRPD3/U2AF2/PPIL1/THOC6/RBM8A/SNRPF/SRSF6/RBM17/PCBP1/USP39/SNRPG/SNRPB/SRSF3/HNRNPA1L3/HNRNPM/SNRPD2/LSM4/SNRNP70/HNRNPK/SNRPC/THOC3/ISY1/HSPA8/SF3A3/HNRNPU	2.89797521062387
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	36/1010	216/9376	1.54719471947195	HSPD1/HSP90AB1/CD14/CCL3/HSP90AA1/HSPA1A/HSPA1B/NCF4/OLR1/TNF/PPARG/CD36/CCL3L1/IL1B/CXCL3/CD40LG/CYBB/CYP2J2/HSPA4/TLR4/TP53/HRAS/AKT1/SOD2/LY96/POU2F2/CCL5/ATF4/CXCL2/MAP2K3/CXCL1/RXRB/PIK3R2/CDC42/CXCL8/HSPA8	2.82688688784211
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	9/1010	32/9376	2.61089108910891	LDHB/ACSS1/LDHA/ECHS1/PCCB/BCKDHA/ACACA/MCEE/HADHA	3.17148125171307
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/1010	62/9376	2.09619929734909	HSPA1A/CAT/HSPA1B/IGF1/PRKACA/SOD1/HRAS/AKT1/HDAC2/SOD2/PIK3R2/PRKAG1/CLPB/HSPA8	3.00887843909975
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/1010	75/9376	1.98040924092409	ASS1/IDH1/RPIA/TKT/PHGDH/SHMT1/IDH2/ACY1/BCAT2/ARG2/BCAT1/PKLR/PYCR2/TALDO1/SHMT2/PGAM1	2.96183322464022
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1010	63/9376	2.06292629262926	GTF2H1/DDB1/POLR2E/POLR2J3/RAD23A/POLR2A/POLD4/POLD1/GTF2H4/CDK7/PCNA/LIG1/ERCC5/RAD23B	2.94114217032272
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	13/1010	57/9376	2.11721382664582	CPT2/ECHS1/FADS1/HSD17B4/HSD17B8/MECR/PPT2/ACACA/HADH/HADHB/FADS2/HADHA/ACADVL	2.93952033456819
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	21/1010	112/9376	1.74059405940594	PPIF/HLA-DRB1/HLA-DRA/HSPA1A/HSPA1B/TNF/HLA-DPA1/IFNGR2/ALOX5/NFKBIB/CD40LG/TLR4/HLA-DMA/HLA-DPB1/AKT1/HLA-DRB5/LY96/IL10RB/HLA-DMB/MAP2K3/HSPA8	2.7395381785404
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	25/1010	144/9376	1.61166116611661	CD14/C1QA/C1QB/C1QC/ALDH7A1/ADIPOR2/C2/ADH5/TNF/IL1B/CXCL3/TLR4/C3AR1/AKT1/LY96/LEF1/ALDH3A2/ACACA/CXCL2/MAP2K3/CXCL1/PRKAG1/ALDH1B1/CXCL8/ACADVL	2.56999129006868
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/1010	67/9376	1.93976651396483	LDHB/ACSS1/LDHA/ALDH7A1/ADH5/MINPP1/PCK2/PDHA1/AKR1A1/PKLR/ALDH3A2/ALDH1B1/PGAM1/DLAT	2.68221290196948
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1010	75/9376	1.85663366336634	GSTT1/GSTO1/TOP2A/GSTA3/GSTA4/GSTM3/GSTM5/PMAIP1/TP53/AKT1/MGST3/BIRC5/MSH6/PIK3R2/MGST2	2.58790507024619
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1010	75/9376	1.85663366336634	CCNE1/ZNF385A/CCNB1/CDK4/IGF1/PTEN/CDK1/PMAIP1/TP53/CCNB2/SESN2/SHISA5/EI24/SIAH1/CCNG1	2.58790507024619
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	19/1010	103/9376	1.71242910698837	CD14/GNAS/SERPINB6/HSPB1/ACTN4/TNF/IL1B/COL4A1/PRKACA/CXCL3/ARG2/TLR4/PRDX1/ITGB2/CXCL2/CXCL1/RAB5C/PIK3R2/CXCL8	2.52602434663722
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	17/1010	90/9376	1.75348734873487	ADIPOR2/CAT/EHMT2/PPARG/ATF6B/IGF1/PRKACA/TP53/HRAS/AKT1/SOD2/SESN2/ATF4/EIF4EBP1/PIK3R2/PRKAG1/STK11	2.49557298003522
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/1010	250/9376	1.41104158415842	DAB2/CLTA/HSPA1A/FOLR2/HSPA1B/HLA-E/SPG21/SNX5/CHMP4A/SNX3/RUFY1/HLA-C/HLA-A/AP2M1/AP2A2/SNX2/ARPC1B/ARRB1/HLA-B/GRK3/DNM1/HRAS/ARFGAP2/HLA-G/FOLR1/EPN1/EHD3/CLTC/WASHC1/RAB5C/HLA-F/CDC42/AP2S1/DNAJC6/SPART/ACAP1/HSPA8/ARPC1A	2.28877408673425
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	29/1010	181/9376	1.48735845960287	HSPD1/HLA-DRB1/CD14/HLA-DRA/FCGR2A/ATP6V0C/MRC1/TNF/HLA-DPA1/IFNGR2/IL1B/CARD9/FCGR1A/HSPA9/TLR4/HLA-DMA/HLA-DPB1/CD209/AKT1/ITGB2/HLA-DRB5/IL10RB/HLA-DMB/CTSS/LSP1/RAB5C/ATP6V0D1/TLR1/ATP6V0A1	2.30037863079826
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/1010	100/9376	1.6709702970297	HLA-DRB1/CD14/HLA-DRA/CSF1R/CD4/TNF/HLA-DPA1/EPOR/CD36/IL1B/CD33/FCGR1A/HLA-DMA/CSF2RA/HLA-DPB1/HLA-DRB5/HLA-DMB/GYPA	2.34374479147523
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1010	21/9376	2.65233380480905	BCAT2/BCAT1/COASY/ALDH3A2/ALDH1B1/AASDHPPT	2.63374021146739
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	19/1010	108/9376	1.63314998166483	EEF1A1/DDX39B/RAN/KPNA2/NUP62/KPNB1/THOC6/RBM8A/IPO5/IPO4/XPOT/DDX19A/NUP160/AAAS/SUMO3/THOC3/RNPS1/XPO1/UBE2I	2.29939116742417
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1010	33/9376	2.25046504650465	IDH1/IDH2/ACY1/BCAT2/PDHA1/BCAT1/BCKDHA/DLAT	2.50018846492281
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/1010	59/9376	1.88810203054204	NME4/NME1/TYMS/TK1/DUT/NME2/ENTPD6/DHODH/NT5M/CAD/DTYMK/UMPS	2.37759684656958
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	14/1010	73/9376	1.78033364980334	MLLT1/SMARCB1/RAN/NELFE/CHMP4A/CD4/SUPT4H1/PPIA/NELFCD/KAT2A/FEZ1/PSIP1/CDK9/XPO1	2.32550699218863
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	6/1010	22/9376	2.53177317731773	HNMT/ALDH7A1/CNDP2/AOC1/ALDH3A2/ALDH1B1	2.49916259971368
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1010	28/9376	2.32079207920792	ATP6V0C/ATP6V1B2/CA2/ATP6V1C2/SLC12A7/ATP6V0D1/ATP6V0A1	2.43187649190153
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/1010	82/9376	1.69814054576189	NME4/IMPDH2/NME1/GSTT1/GSTO1/GSTA3/TK1/GSTA4/GSTM3/GSTM5/DUT/NME2/MGST3/MGST2/UMPS	2.2061541182751
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	13/1010	68/9376	1.77472335468841	CD14/MYC/CEBPA/CSF1R/SPI1/FCGR1A/CCNA2/HRAS/AKT1/LEF1/EIF4EBP1/PIK3R2/STAT5A	2.22771850463844
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	34/1010	227/9376	1.39043049679417	GNAS/CCL3/MYC/HLA-E/HLA-C/HLA-A/TNF/ATF6B/CCL4/CCL3L1/CDK4/IL1B/PRKACA/HLA-B/CCL4L2/TAPBP/TP53/E2F2/HRAS/GNG10/HLA-G/RAC3/AKT1/TAP1/CCL5/ATF4/GNB4/IL10RB/EIF4EBP1/GNG12/PIK3R2/HLA-F/CXCL8/CRK	2.06898452862953
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/1010	142/9376	1.50361176962767	HSP90AB1/MEF2C/ASS1/HSP90AA1/TXN2/HMOX1/GSTT1/TNF/CTSL/GSTO1/IL1B/GSTA3/GSTA4/GSTM3/GSTM5/TP53/RAC3/AKT1/MGST3/SQSTM1/PIK3R2/SUMO3/MGST2	2.10103120772814
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1010	23/9376	2.42169608265174	SSBP1/POLD4/POLD1/MSH6/PCNA/LIG1	2.37182483712894
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1010	42/9376	1.98925035360679	ALDH7A1/CAT/ECHS1/AOC1/AFMID/ALDH3A2/HADH/ALDH1B1/HADHA	2.232463443529
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1010	42/9376	1.98925035360679	SLC40A1/HMOX1/NCOA4/CYBB/PCBP1/TP53/LPCAT3/GCLM/SLC11A2	2.232463443529
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/1010	99/9376	1.59407940794079	HLA-DRB1/C1QA/C1QB/C1QC/HLA-DRA/FCGR2A/C2/HLA-DPA1/FCGR1A/C3AR1/CFD/HLA-DMA/HLA-DPB1/ITGB2/HLA-DRB5/HLA-DMB/FPR1	2.06464654151176
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/1010	18/9376	2.57865786578658	NEU1/MAN2B1/HEXA/HEXB/FUCA1	2.32927167199889
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/1010	50/9376	1.85663366336634	HLA-DRB1/HLA-DRA/HLA-DPA1/CD40LG/HLA-DMA/HLA-DPB1/HLA-DRB5/CD86/HLA-DMB/TNFSF13	2.11018158411927
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/1010	50/9376	1.85663366336634	TNF/CD36/IL1B/GYPB/CD40LG/HBA1/TLR4/ITGB2/GYPA/CXCL8	2.11018158411927
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/1010	71/9376	1.69973504392693	ATP6V0C/ATP6V1B2/ATP6V1C2/CXCL3/CCL5/CXCL2/CXCL1/CDC42/PLCG2/CXCL8/ATP6V0D1/ATP6V0A1/HBEGF	2.05632618243002
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/1010	44/9376	1.8988298829883	PARP1/APEX1/MUTYH/HMGB1/POLD4/POLD1/UNG/PCNA/LIG1	2.07636581895891
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	18/1010	109/9376	1.53300027250431	SPP1/CD14/CCL3/TNF/CCL4/CCL3L1/IL1B/CCL4L2/TLR4/TLR7/AKT1/CD86/LY96/CCL5/MAP2K3/PIK3R2/CXCL8/TLR1	1.94472632670443
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1010	19/9376	2.44293903074518	GCSH/AMT/PDHA1/BCKDHA/DLAT	2.18747884521587
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	24/1010	158/9376	1.41010151648076	RPS6/SKP2/ATP6V1B2/TNF/ATP6V1C2/STRADB/EIF4B/IGF1/LAMTOR1/WNT5B/PTEN/RPS6KA1/PRR5/HRAS/AKT1/SESN2/EIF4EBP1/RRAGA/FZD5/PIK3R2/MLST8/STK11/FZD3/DEPTOR	1.80629617298444
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	14/1010	83/9376	1.56583561970655	IDH1/CAT/ECH1/DHRS4/IDH2/SOD1/HSD17B4/PRDX1/PEX6/SOD2/DECR2/SLC27A2/EPHX2/ECI2	1.79903145035703
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/1010	106/9376	1.48881001307678	HSP90AB1/CCNE1/HSP90AA1/FOLR2/SLC19A1/IGF1/PTEN/TP53/E2F2/HRAS/ETV5/FOLR1/AKT1/LEF1/ATF4/PIK3R2/SLC46A1	1.75849263693582
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/1010	78/9376	1.54719471947195	CD14/C1QA/C1QB/C1QC/C2/TNF/IL1B/C4BPB/TLR4/ITGB2/LY96/SERPING1/CXCL8	1.68609415589554
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1010	28/9376	1.98925035360679	ECHS1/MECR/PPT2/HADH/HADHB/HADHA	1.82143330310123
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/1010	71/9376	1.56898619439409	LDHB/LDHA/IDH1/MYC/IDH2/PTEN/PDHA1/TP53/HRAS/AKT1/PIK3R2/PGAM1	1.6720917712047
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	18/1010	117/9376	1.42817974105103	INO80D/SMARCB1/MBD3/RBBP7/TFPT/RUVBL1/MTA1/SMARCA1/CHD4/HDAC2/BCL7A/NFRKB/INO80B/CDK2AP1/SRCAP/INO80C/DMAP1/VPS72	1.61928912414262
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	25/1010	173/9376	1.34149831168088	SLC25A6/HLA-DRB1/HLA-DRA/SLC25A5/KPNA2/TNF/HLA-DPA1/IFNGR2/CDK4/CPSF4/IL1B/NFKBIB/PABPN1/TLR4/HLA-DMA/TLR7/HLA-DPB1/AKT1/HLA-DRB5/DNAJB1/CCL5/HLA-DMB/PIK3R2/CXCL8/XPO1	1.5751948979443
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	13/1010	79/9376	1.52760997618749	CLTA/ATP6V0C/ATP6V1B2/AP2M1/ATP6V1C2/AP2A2/NSF/DNM1/CLTC/AP2S1/SLC6A4/ATP6V0D1/ATP6V0A1	1.63622311565318
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/1010	110/9376	1.43467146714671	LDHB/FLT1/LDHA/RPS6/EGLN2/HMOX1/IFNGR2/ANGPT1/IGF1/CYBB/PDHA1/TLR4/AKT1/EIF4EBP1/ELOC/PIK3R2/PLCG2	1.5933042795363
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	34/1010	248/9376	1.27269243053338	HSP90AB1/CD14/TUBB/TUBA1B/RPS3/HSP90AA1/TXN2/MYC/TUBA1C/CYFIP1/DYNLRB1/TNF/RILP/GSDMD/IL1B/ARPC1B/SKP1/TLR4/TUBB4B/HRAS/SNX18/AKT1/LY96/LEF1/MAP2K3/RAB5C/PKN1/CDC42/NAIP/PFN1/CXCL8/ARPC1A/DYNLL2/VPS11	1.51216263476004
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1010	16/9376	2.32079207920792	GBGT1/HEXA/B3GALNT1/HEXB	1.83714704143533
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	21/1010	143/9376	1.36326248009416	HLA-DRB1/C1QA/C1QB/C1QC/HLA-DRA/FCGR2A/ACTN4/C2/TNF/HLA-DPA1/SNRPD1/SNRPD3/FCGR1A/CD40LG/HLA-DMA/SNRPB/HLA-DPB1/HLA-DRB5/CD86/HLA-DMB/SSB	1.52091358675381
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	30/1010	217/9376	1.28338732490761	HSP90AB1/GNAS/HSP90AA1/MYC/KPNA2/GSTT1/ATF6B/GSTO1/KPNB1/GSTA3/GSTA4/GSTM3/GSTM5/ARRB1/PRKACA/RPS6KA1/HRAS/AKT1/MGST3/BIRC5/PTGES3/ADRB1/ATF4/EIF4EBP1/RXRB/PIK3R2/EPHX2/STAT5A/EPHX1/MGST2	1.46748494332486
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	19/1010	128/9376	1.3779702970297	NME4/IMPDH2/PNP/AK6/PAICS/NME1/ADSL/ATIC/AK1/NME2/NTPCR/GART/GMPR2/AK3/ENTPD6/AK2/NT5M/HDDC3/PFAS	1.49598121866184
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	28/1010	201/9376	1.29317767597655	MLLT1/CD14/MEF2C/LMO2/FLT1/LYL1/MYCN/MYC/CEBPA/CSF1R/SPI1/PPARG/LDB1/IGF1/FCGR1A/CCNA2/HHEX/TP53/BMI1/NUPR1/ETV5/HDAC2/CD86/RXRB/CDK9/TAF15/CXCL8/MEN1	1.4598669782789
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/1010	66/9376	1.54719471947195	HLA-DRB1/HLA-DRA/TNF/HLA-DPA1/IFNGR2/IL1B/TLR4/HLA-DMA/HLA-DPB1/HLA-DRB5/HLA-DMB	1.5499811621495
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	16/1010	105/9376	1.41457802923149	CD14/PARP1/CSNK2B/TNF/CCL4/IL1B/CCL4L2/CXCL3/CD40LG/TLR4/LY96/CXCL2/CXCL1/PLCG2/CXCL8/UBE2I	1.48431144680218
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/1010	105/9376	1.41457802923149	GABARAP/CSNK2B/VCP/TP53/PHB2/HRAS/TFEB/TOMM40/RHOT2/SQSTM1/ATF4/RAB5C/CCZ1/PGAM5/FKBP8/SIAH1	1.48431144680218
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1010	37/9376	1.75627508696816	MYC/NCOA4/PPARG/TP53/HRAS/LEF1/RXRB	1.60146651890929
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	20/1010	137/9376	1.35520705355207	CTSB/PARP1/TUBA1B/TUBA1C/TNF/CTSL/DAXX/PMAIP1/TP53/HRAS/DFFA/AKT1/BIRC5/ATF4/CTSS/AIFM1/PIK3R2/LMNB1/CTSZ/HTRA2	1.45518019792547
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	24/1010	170/9376	1.31056493884683	MYC/SMARCB1/HMOX1/GSTT1/GSTO1/CDK4/GSTA3/GSTA4/GSTM3/GSTM5/WNT5B/PTEN/TP53/E2F2/HRAS/AKT1/MGST3/LEF1/TXNRD1/FZD5/PIK3R2/PLCG2/MGST2/FZD3	1.41980530636657
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1010	52/9376	1.60670220868241	HSD17B1/GNAS/SCARB1/IGF1/ALOX5/PRKACA/CGA/CYP2J2/PLA2G4C	1.52427564448388
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/1010	98/9376	1.42089310971914	FCGR2A/MARCKSL1/INPP5D/ARPC1B/MARCKS/FCGR1A/AKT1/HCK/WASF1/PIK3R2/PLA2G4C/CDC42/PLCG2/CRK/ARPC1A	1.45527498708215
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1010	83/9376	1.45399021829894	GSDMD/CCL4/POLR2E/IL1B/NFKBIB/G3BP1/CCL4L2/PCBP1/GSDME/CCL5/ZCCHC3/POLR1D/DDX41	1.44342747686655
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1010	38/9376	1.71005732152163	QPRT/PNP/NAPRT/NMNAT3/SIRT2/NT5M/NADK	1.5238621017668
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1010	31/9376	1.79674225487065	ALDH7A1/CNDP2/ECHS1/ALDH3A2/ALDH1B1/HADHA	1.54381920570966
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/1010	149/9376	1.30836600438567	NDUFA7/NDUFS3/NDUFA3/NDUFA6/NDUFS1/NDUFA13/NDUFA11/NDUFV3/PRKACA/NDUFB9/NAPEPLD/NDUFA10/NDUFS2/GNG10/NDUFA8/GNB4/NDUFC1/GNG12/NDUFC2/GABRA3/NDUFV1	1.31830762000181
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/1010	133/9376	1.32616690240453	FOXO4/GABARAP/CAT/SKP2/CCNB1/IGF1/PTEN/PCK2/PRMT1/CCNB2/HRAS/AKT1/SOD2/CSNK1E/SGK3/PIK3R2/DEPP1/PRKAG1/STK11	1.31627498567203
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	14/1010	93/9376	1.39746619823273	HLA-DRB1/HLA-DRA/CD4/HLA-DPA1/IFNGR2/NFKBIB/NFKBIE/MAML1/HLA-DMA/HLA-DPB1/HLA-DRB5/HLA-DMB/STAT5A/RBPJ	1.3383968161189
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	16/1010	109/9376	1.36266690889272	HSP90AB1/HLA-DRB1/HLA-DRA/HSP90AA1/CD4/HLA-DPA1/IFNGR2/IL1B/NFKBIB/NFKBIE/HLA-DMA/HLA-DPB1/HLA-DRB5/HLA-DMB/RXRB/STAT5A	1.32324113500803
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1010	70/9376	1.45878359264498	ADIPOR2/TNF/CD36/NFKBIB/NFKBIE/PCK2/AKT1/POMC/RXRB/PRKAG1/STK11	1.33863682760617
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	15/1010	103/9376	1.35191771604345	C1QA/GNAS/C1QB/C1QC/CCL3/TNF/CCL3L1/IFNGR2/IL1B/PPP2CA/TLR4/AKT1/CCL5/PIK3R2/CXCL8	1.24777709110814
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1010	41/9376	1.58493117604443	SSBP1/RAD50/TOP3A/POLD4/POLD1/BABAM1/ABRAXAS1	1.30414815551291
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1010	41/9376	1.58493117604443	MYC/CDK4/TP53/E2F2/HRAS/CXCL8/HBEGF	1.30414815551291
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1010	13/9376	2.14226961157654	RAD50/XRCC6/NHEJ1	1.43192470687998
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1010	27/9376	1.71910524385772	ECHS1/ALDH5A1/HADH/BDH1/HADHA	1.30010716845545
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	28/1010	214/9376	1.21462015360415	HLA-E/HLA-C/CD4/HLA-A/CCNB1/TNF/DDB1/SKP1/HLA-B/TAPBP/CDK1/TLR4/CCNB2/HRAS/GNG10/HLA-G/RAC3/AKT1/TAP1/GNB4/MAP2K3/GNG12/ELOC/PIK3R2/HLA-F/AP1B1/PLCG2/CRK	1.10349314411732
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/1010	122/9376	1.29355624086999	EEF2/ADIPOR2/PPARG/STRADB/EEF2K/CD36/PPP2R3B/IGF1/CCNA2/PCK2/PPP2CA/AKT1/ACACA/EIF4EBP1/PIK3R2/PRKAG1/STK11	1.1339499349545
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	23/1010	174/9376	1.22708546716741	HSP90AB1/CANX/HSP90AA1/HSPA1A/HSPH1/HSPA1B/BAG2/ATF6B/TXNDC5/NSFL1C/RNF5/VCP/SKP1/RAD23A/DNAJA1/DNAJB1/ATF4/HYOU1/YOD1/UBE2G2/HSPA8/RAD23B/DNAJA2	1.05053432277623
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1010	28/9376	1.65770862800566	AKR1B1/PCBD1/MOCS1/QDPR/DHFR	1.21099011430093
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1010	51/9376	1.45618326538536	GNAS/ATP6V0C/ATP6V1B2/ATP6V1C2/PRKACA/PLCG2/ATP6V0D1/ATP6V0A1	1.13497791887669
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/1010	93/9376	1.29764718407325	CCNE1/MYC/SKP2/CDK4/COL4A1/PTEN/TP53/E2F2/CKS2/AKT1/CKS1B/RXRB/PIK3R2	1.00227401792072
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1010	37/9376	1.50537864597271	ASS1/ADSL/ALDH5A1/RIMKLB/NIT2/CAD	1.0701753830628
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/1010	69/9376	1.3453867125843	TNF/INPP5D/ALOX5/HRAS/RAC3/AKT1/MAP2K3/PIK3R2/PLA2G4C/PLCG2	1.00048990084846
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1010	53/9376	1.40123295348403	CLTA/GNAS/AP2M1/AP2A2/PRKACA/DNM1/CLTC/AP2S1	1.01775696305549
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1010	15/9376	1.85663366336634	HEXA/HEXB/ST6GALNAC6	1.15363132169903
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1010	15/9376	1.85663366336634	AK1/NTPCR/AK2	1.15363132169903
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/1010	103/9376	1.26178986830722	DDX39B/CPSF1/CPSF4/PPP2R3B/RBM8A/PABPC4/PPP2CA/PABPN1/PPP1CC/NUDT21/SSU72/DDX19A/CPSF3/RNPS1	0.928215277225867
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	10/1010	70/9376	1.32616690240453	GSTT1/GSTO1/GSTA3/GSTA4/GSTM3/GSTM5/MGST3/SULT1A1/EPHX1/MGST2	0.951688409316752
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1010	23/9376	1.61446405510116	ASS1/ACY1/ARG2/CAD	1.02511438639794
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/1010	88/9376	1.26588658865887	C1QA/F13A1/C1QB/C1QC/C2/VSIG4/SERPINE2/C4BPB/C3AR1/CFD/ITGB2/SERPING1	0.870691008755336
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	24/1010	193/9376	1.15438362489099	CCL3/CCL4/CCL3L1/NFKBIB/ARRB1/PRKACA/CCL4L2/GRK3/CXCL3/HRAS/GNG10/RAC3/AKT1/HCK/CCL5/CXCL2/GNB4/CXCL1/GNG12/PIK3R2/CDC42/PLCG2/CXCL8/CRK	0.752965349802321
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1010	32/9376	1.45049504950495	GABARAP/ATG4C/PPP2CA/MLST8/WIPI2	0.886923152753194
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	12/1010	90/9376	1.23775577557756	CSNK2B/CD4/IFNGR2/NFKBIB/NFKBIE/PTEN/TLR4/HRAS/AKT1/MAP2K3/PIK3R2/PDCD1	0.787454348603067
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	9/1010	65/9376	1.28536176694593	AKR1B1/ALDH7A1/ABHD16A/AGPAT5/DGAT1/AKR1A1/AGPAT1/ALDH3A2/ALDH1B1	0.80212434088536
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	20/1010	160/9376	1.16039603960396	HLA-DRB1/HLA-DRA/HLA-E/SIGLEC1/HLA-C/CD4/HLA-A/HLA-DPA1/HLA-B/CD40LG/HLA-DMA/HLA-G/HLA-DPB1/ITGB2/HLA-DRB5/CD86/ESAM/HLA-DMB/HLA-F/PDCD1	0.711000316438398
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1010	17/9376	1.63820617355853	NRP2/CD209/MYH10	0.915078039284673
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/1010	169/9376	1.15352979084891	CTSB/GABARAP/CTSL/VAMP8/PRKACA/PTEN/ATG4C/HMGB1/PPP2CA/SMCR8/HRAS/AKT1/SQSTM1/RRAGA/PIK3R2/EIF2AK4/MLST8/WIPI2/STK11/DEPTOR/VPS11	0.699784524519735
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	13/1010	100/9376	1.20681188118812	CCL3/CSF1R/TNF/CCL4/CCL3L1/CCL4L2/CXCL3/TNFRSF14/CCL5/CXCL2/IL10RB/CXCL1/CXCL8	0.722407938914156
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/1010	187/9376	1.14178006035898	HSP90AB1/CTSB/YWHAE/HSP90AA1/TXN2/GABARAP/GPSM3/TNF/GSDMD/IL1B/CARD9/NFKBIB/CXCL3/CYBB/TLR4/CCL5/CXCL2/TRIP6/CXCL1/PKN1/NAIP/TRPM2/CXCL8	0.680439049712398
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/1010	196/9376	1.13671448777531	MYC/HLA-E/HLA-C/HLA-A/CDK4/HLA-B/CXCL3/TP53/E2F2/HRAS/GNG10/HLA-G/AKT1/HCK/CD86/LEF1/CXCL2/GNB4/CXCL1/GNG12/PIK3R2/HLA-F/PLCG2/CXCL8	0.67206090074181
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1010	10/9376	1.85663366336634	MPST/SELENBP1	0.941684571945353
Human Diseases	Infectious disease: viral	hsa05162	Measles	17/1010	136/9376	1.16039603960396	CCNE1/RACK1/HSPA1A/HSPA1B/CSNK2B/CDK4/IL1B/NFKBIB/TLR4/TP53/TLR7/EIF3H/CD209/AKT1/PIK3R2/STAT5A/HSPA8	0.654658037574617
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1010	76/9376	1.22146951537259	PLTP/CPT2/OLR1/PPARG/CD36/PCK2/PLIN2/SLC27A2/RXRB/FADS2	0.673545086243456
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/1010	59/9376	1.25873468702802	MYC/PTEN/TP53/HRAS/AKT1/LEF1/PIK3R2/CTNNA1	0.692675790416268
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1010	34/9376	1.36517181129878	SKP1/BHLHE41/CSNK1E/PRKAG1/DBP	0.74114668030072
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1010	18/9376	1.54719471947195	HSD17B8/MECR/ACACA	0.807372633904006
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/1010	77/9376	1.20560627491321	MYC/CDK4/TP53/E2F2/HRAS/AKT1/HDAC2/PIK3R2/STAT5A/CRK	0.629435159589815
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	17/1010	138/9376	1.14357870569666	CCNE1/YWHAE/MAD1L1/CDC20/CCNB1/YWHAH/IGF1/PRKACA/SKP1/RPS6KA1/REC8/AURKA/PPP2CA/CDK1/PPP1CC/CCNB2/PTTG1	0.590375047112313
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/1010	60/9376	1.23775577557756	HSPB1/HRAS/RAC3/AKT1/PIK3R2/PLA2G4C/CDC42/PLCG2	0.641917707317377
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/1010	78/9376	1.19014978420919	CLTA/ARPC1B/DNM1/CLTC/WASF1/PIK3R2/CDC42/CRK/ARPC1A/CTNNA1	0.585916545776079
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/1010	157/9376	1.12344075171848	C1QA/STAB1/C1QB/C1QC/DUSP8/SLC16A1/PPARG/EPOR/CD36/RAB17/ALOX5/ARG2/SIRPA/RAB5C/BSG/CRK/DUSP16/DNMT3A/VPS11	0.541943324915186
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1010	44/9376	1.26588658865887	MGAT4B/MAN2A2/HEXA/HEXB/ALG1/ALG3	0.614218368636554
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/1010	44/9376	1.26588658865887	GTF2H1/TAF9/GTF2H4/CDK7/TAF15/TAF6L	0.614218368636554
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1010	19/9376	1.46576341844711	HEXA/HEXB/HYAL3	0.706091943609226
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	10/1010	79/9376	1.1750845970673	GSTT1/ADH5/GSTO1/GSTA3/GSTA4/GSTM3/GSTM5/MGST3/EPHX1/MGST2	0.542972039661621
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/1010	107/9376	1.12786157120385	LDHB/GNAS/LDHA/PRKACA/PCK2/PDHA1/PRMT1/AKT1/PPP4C/ATF4/ACACA/PRKAG1/PGAM1	0.462171200532289
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1010	63/9376	1.17881502435958	ALDH7A1/EHMT2/ECHS1/ALDH3A2/HADH/ALDH1B1/HADHA/COLGALT1	0.494785398082797
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1010	29/9376	1.28043700921816	RASSF4/RASSF6/CSNK1E/MOB1B	0.525515583984906
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/1010	73/9376	1.144500203445	GSTT1/ADH5/GSTO1/GSTA3/GSTA4/GSTM3/GSTM5/MGST3/MGST2	0.430631478686997
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/1010	73/9376	1.144500203445	CDK4/TP53/E2F2/HRAS/AKT1/RXRB/PIK3R2/STAT5A/PLCG2	0.430631478686997
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1010	38/9376	1.22146951537259	CD4/CD40LG/TAP1/UNG/IGLL1	0.475298248386093
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/1010	109/9376	1.10716686347534	TNF/MLXIP/CD36/PTEN/RPS6KA1/PCK2/PPP1CC/PPARGC1B/AKT1/SLC27A2/PIK3R2/PRKAG1/PTPA	0.391013347463425
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/1010	101/9376	1.10295069110871	TNF/CDK4/IL1B/COL4A1/CYBB/HRAS/AKT1/PIK3R2/CDC42/STAT5A/PLCG2/CXCL8	0.361426830379226
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	13/1010	110/9376	1.09710171017102	HSP90AB1/HSP90AA1/MAD1L1/CCNB1/IGF1/PRKACA/RPS6KA1/CCNA2/AURKA/CDK1/CCNB2/AKT1/PIK3R2	0.355929896621337
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	21/1010	183/9376	1.06528161012823	AK6/RAN/FBL/CSNK2B/NOB1/EMG1/UTP4/WDR43/NHP2/NOP56/DKC1/RPP25L/GNL3/UTP14A/RCL1/NAT10/IMP3/XPO1/LSG1/TBL3/GAR1	0.30986688564992
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/1010	138/9376	1.07630937006744	FCGR2A/CD4/TNF/IL1B/ARPC1B/RPS6KA1/TLR4/RAC3/AKT1/MAP2K3/PKN1/PIK3R2/CDC42/CXCL8/CRK/ARPC1A	0.313773186142643
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	14/1010	120/9376	1.08303630363036	BEX3/YWHAE/NFKBIB/NFKBIE/RPS6KA1/MAGED1/TP53/HRAS/AKT1/ATF4/PIK3R2/CDC42/PLCG2/CRK	0.318078528287625
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1010	31/9376	1.19782816991377	ALDH7A1/AKR1A1/ALDH3A2/ALDH1B1	0.383324627602247
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/1010	76/9376	1.09932256383533	CDK4/IGF1/PTEN/TP53/E2F2/HRAS/AKT1/PIK3R2/PLCG2	0.302065161030595
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	37/1010	333/9376	1.03146314631463	SPP1/CCNE1/GNAS/ATP6V0C/HLA-E/HLA-C/HLA-A/ATP6V1B2/TNF/ATP6V1C2/CDK4/PPP2R3B/COL4A1/WNT5B/PRKACA/PTEN/HLA-B/PSMC1/CCNA2/MAML1/PPP2CA/TP53/HRAS/HLA-G/SCRIB/AKT1/CHD4/HDAC2/EIF4EBP1/FZD5/PIK3R2/HLA-F/CDC42/ATP6V0D1/ATP6V0A1/FZD3/RBPJ	0.203121266698845
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1010	23/9376	1.21084804132587	LARGE2/B3GALNT2/CHST10	0.351759161032445
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1010	23/9376	1.21084804132587	CA2/PCK2/MDH1	0.351759161032445
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/1010	142/9376	1.04599079626272	FCGR2A/CSF1R/NCF4/SPI1/TNF/PPARG/IFNGR2/IL1B/FCGR1A/LILRB5/AKT1/LILRB4/SQSTM1/SIRPA/PIK3R2/PLCG2	0.191870214406806
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/1010	87/9376	1.06703084101514	MYC/PMAIP1/TP53/HRAS/RAC3/AKT1/BIRC5/LEF1/MSH6/PIK3R2	0.218241434813165
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/1010	78/9376	1.07113480578827	HSPD1/LSM2/EXOSC4/PARN/PABPC4/HSPA9/CNOT3/LSM4/EXOSC3	0.219190675736258
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	33/1010	300/9376	1.02114851485148	DUSP9/CD14/MEF2C/FLT1/HSPA1A/HSPB1/MYC/HSPA1B/DUSP8/CSF1R/TNF/DAXX/ANGPT1/IL1B/IGF1/ARRB1/PRKACA/RPS6KA1/PGF/TP53/HRAS/RAC3/AKT1/STMN1/ATF4/DUSP3/MAP2K3/GNG12/PLA2G4C/CDC42/CRK/HSPA8/DUSP16	0.1293542354179
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/1010	70/9376	1.06093352192362	EGLN2/HRAS/FH/AKT1/ELOC/PIK3R2/CDC42/CRK	0.177791572737926
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/1010	61/9376	1.06528161012823	SLC40A1/HMOX1/HMOX2/SLC39A4/SLC46A1/CYBRD1/SLC11A2	0.177726316661926
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	18/1010	163/9376	1.02513515155197	CCNE1/MYC/TNF/DDB1/ATF6B/CCNA2/TLR4/TP53/E2F2/HRAS/AKT1/BIRC5/ATF4/MAP2K3/PIK3R2/PCNA/STAT5A/CXCL8	0.112476597392892
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/1010	34/9376	1.09213744903902	POLR2E/POLR2J3/POLR2A/POLR1D	0.187000645651633
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1010	44/9376	1.05490549054905	GNAS/NSF/PRKACA/RAB5C/DYNLL2	0.126835885195768
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/1010	119/9376	1.01412763125052	TNF/ATF6B/IL1B/CXCL3/AKT1/CCL5/ATF4/CXCL2/MAP2K3/CXCL1/PIK3R2/MMP14/PGAM5	0.0538883758509684
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/1010	91/9376	1.02012838646502	INPP5D/NFKBIB/NFKBIE/HRAS/LILRB5/RAC3/AKT1/LILRB4/PIK3R2/PLCG2	0.0670387795632899
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1010	63/9376	1.03146314631463	ALOX5/PTGES2/CYP2J2/PRXL2B/PTGES3/PLA2G4C/EPHX2	0.0870592693761434
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	39/1010	362/9376	1.00012034352607	SPP1/HSP90AB1/CCNE1/CSH1/YWHAE/FLT1/HSP90AA1/RPS6/MYC/CSF1R/ATF6B/EPOR/YWHAH/CDK4/ANGPT1/PPP2R3B/EIF4B/IGF1/LPAR6/COL4A1/PTEN/MYB/PCK2/PPP2CA/PGF/TLR4/TP53/HRAS/GNG10/AKT1/ATF4/GNB4/EIF4EBP1/SGK3/PKN1/GNG12/PIK3R2/MLST8/STK11	0.00081134513342316
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/1010	157/9376	1.00518383048496	YWHAE/BMP7/MYC/YWHAH/WNT5B/RASSF6/PPP2CA/PPP1CC/SCRIB/ITGB2/BIRC5/LEF1/CSNK1E/FZD5/MOB1B/FZD3/CTNNA1	0.0227586294615454
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/1010	73/9376	1.01733351417334	CDK4/IGF1/PTEN/TP53/E2F2/HRAS/AKT1/PIK3R2	0.0516563759866701
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	15/1010	139/9376	1.00178075361493	HSP90AB1/FKBP4/GNAS/HSP90AA1/HSPA1A/HSPA1B/ATF6B/PRKACA/HRAS/AKT1/ATF4/POMC/PIK3R2/HSPA8/HBEGF	0.00734908309514665
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1010	26/9376	1.07113480578827	SCARB1/SLC19A1/SLC46A1	0.126197401822696
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/1010	168/9376	0.994625176803395	SLC25A6/HSP90AB1/PARP1/HSP90AA1/SLC25A5/CHMP4A/TNF/IFNGR2/IL1B/PPIA/HMGB1/CYBB/TLR4/SQSTM1/AIFM1/PLA2G4C/STAT5A/PGAM5	-0.024424380851823
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/1010	93/9376	0.998190141594805	GNAS/PRKACA/CGA/HRAS/ATF4/MAP2K3/MMP14/PLA2G4C/CDC42/HBEGF	-0.00609437667381508
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/1010	122/9376	0.989190066547638	CD4/TNF/CDK4/PPP2R3B/NFKBIB/NFKBIE/CD40LG/PPP2CA/HRAS/AKT1/PIK3R2/CDC42/PDCD1	-0.0417566436293095
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/1010	122/9376	0.989190066547638	MYC/MED16/SLC16A10/PRKACA/KAT2A/TP53/HRAS/AKT1/HDAC2/RXRB/PIK3R2/MED17/PLCG2	-0.0417566436293095
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/1010	122/9376	0.989190066547638	CSH1/GNAS/ATF6B/IGF1/PRKACA/HRAS/AKT1/ATF4/MAP2K3/PIK3R2/STAT5A/PLCG2/CRK	-0.0417566436293095
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1010	17/9376	1.09213744903902	SEPHS2/TXNRD1	0.132109277071396
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1010	27/9376	1.03146314631463	FADS1/HSD17B4/FADS2	0.0568838322557256
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/1010	142/9376	0.980616371496305	PRPF19/CDC20/SKP2/DDB1/UBE2C/RHOBTB1/SKP1/UBE2F/HERC2/ELOC/HERC3/UBE2G2/KLHL9/SIAH1/UBE2I	-0.0808670703533842
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/1010	86/9376	0.971494358738199	MYC/HRAS/AKT1/EIF4EBP1/PIK3R2/STAT5A/PLCG2/CRK/HBEGF	-0.0922697999280426
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/1010	87/9376	0.960327756913622	MYL4/CYC1/UQCR10/UQCRC1/UQCRH/UQCRC2/COX4I2/COX5B/COX8A	-0.129166322879235
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1010	78/9376	0.952119827367352	ISYNA1/IMPA2/INPP5D/MINPP1/PTEN/ITPK1/PIP4K2B/PLCG2	-0.147535194303563
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1010	59/9376	0.944051015271019	GNAS/PRKACA/CGA/AKT1/ADRB1/PIK3R2	-0.149784737660386
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	21/1010	204/9376	0.955620267909144	ANK1/RPS6/MYC/TFAP4/TNF/CTSL/EIF4B/IGF1/WNT5B/PRKACA/TLR4/TP53/PPP1CC/HRAS/AKT1/FZD5/PIK3R2/CDC42/PLCG2/HBEGF/FZD3	-0.222666627739599
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/1010	89/9376	0.938747357881856	TUBB/GNAS/TUBA1B/TUBA1C/PRKACA/CDK1/TUBB4B/HRAS/ADRB1	-0.201729541828306
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/1010	89/9376	0.938747357881856	GABARAP/NSF/PRKACA/SLC38A5/GNG10/GNB4/GNG12/SLC12A5/GABRA3	-0.201729541828306
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/1010	253/9376	0.954001487105232	FOXO4/CD14/ACTN4/TNF/IL1B/ARPC1B/NFKBIB/SKP1/TLR4/TP53/AKT1/CCL5/SQSTM1/CBX3/WASF1/RRAGA/PIK3R2/CDC42/NAIP/PFN1/PLCG2/TIFA/CXCL8/CRK/WIPI2/ARPC1A	-0.257704860386505
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/1010	99/9376	0.937693769376938	GNAS/CDK4/IGF1/PRKACA/TP53/E2F2/HRAS/AKT1/PIK3R2/HBEGF	-0.216537287525979
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/1010	99/9376	0.937693769376938	GNAS/IL1B/IGF1/PRKACA/CYP2J2/PPP1CC/MAP2K3/PIK3R2/PLA2G4C/PLCG2	-0.216537287525979
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/1010	138/9376	0.941770698809011	FLOT1/RPS6/PRKAR2B/PRKACA/PCK2/PPP1CC/HRAS/AKT1/PKLR/ACACA/EIF4EBP1/PIK3R2/PRKAG1/CRK	-0.239430535796699
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/1010	80/9376	0.928316831683168	RPS6/IGF1/PTEN/HRAS/AKT1/EIF4EBP1/PIK3R2/PLCG2	-0.223718306605319
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1010	20/9376	0.928316831683168	NPL/TGDS	-0.111499900196303
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1010	31/9376	0.898371127435324	RPIA/TKT/TALDO1	-0.196922661451461
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	24/1010	238/9376	0.936117813462018	FOXO4/FLT1/CSF1R/ANGPT1/IGF1/PRKACA/RGL1/PGF/HRAS/GNG10/RASA3/RAC3/AKT1/GNB4/RGL2/SYNGAP1/RASA4/RAB5C/GNG12/PIK3R2/PLA2G4C/CDC42/PLCG2/ETS2	-0.346840712131614
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/1010	83/9376	0.894763211260885	CSNK2B/RBBP7/SKP1/RING1/BMI1/DCAF7/HDAC2/CBX3	-0.33459239058586
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/1010	32/9376	0.87029702970297	PMAIP1/BIRC5/HTRA2	-0.255355896726744
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	13/1010	133/9376	0.907377354276781	GNAS/COMT/ATF6B/PPP2R3B/ARRB1/PRKACA/PPP2CA/PPP1CC/GNG10/AKT1/ATF4/GNB4/GNG12	-0.373786766141675
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1010	43/9376	0.863550541100622	SCARB1/DGAT1/CD36/AGPAT1	-0.311589495203153
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/1010	94/9376	0.888813987781757	HSP90AB1/SRSF1/HSP90AA1/TNF/IL1B/CXCL3/CXCL2/CXCL1/CXCL8	-0.37642693703581
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	11/1010	115/9376	0.887955230305639	GNAS/MEF2C/ATF6B/ARRB1/PRKACA/GCM1/NACA/ATF4/RXRB/MMP14/HBEGF	-0.42004803877434
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/1010	155/9376	0.898371127435324	CCNE1/GNAS/SCARB1/ATF6B/CDK4/WNT5B/PRKACA/E2F2/FH/LEF1/ATF4/POMC/FZD5/MEN1/FZD3	-0.443283269878622
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/1010	75/9376	0.86642904290429	CANX/GNAS/GPX3/ATF6B/PRKACA/CGA/ATF4	-0.40352016490601
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/1010	65/9376	0.856907844630617	GNAS/SCARB1/ATF6B/PRKACA/ATF4/POMC	-0.402218215985752
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/1010	65/9376	0.856907844630617	SPP1/ARRB1/CGA/HRAS/AKT1/PIK3R2	-0.402218215985752
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/1010	116/9376	0.880300443837487	ACTN4/NCF4/CYBB/ITGB2/ESAM/PIK3R2/SIPA1/CTNND1/CDC42/PLCG2/CTNNA1	-0.450716478350192
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/1010	55/9376	0.843924392439244	NEU1/SGPP1/HEXA/HEXB/PSAP	-0.403341138589608
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1010	23/9376	0.807232027550581	NLN/ENPEP	-0.321596064333052
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1010	66/9376	0.843924392439244	HSD17B1/COMT/HSD17B8/SRD5A3/DHRS11/DHRS9	-0.442099024317453
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1010	56/9376	0.828854314002829	MGAT4B/MAN2A2/SRD5A3/ALG1/ALG3	-0.446312868313571
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/1010	77/9376	0.843924392439244	CDK4/TP53/E2F2/RAC3/AKT1/PIK3R2/CDC42	-0.477803875365928
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1010	12/9376	0.773597359735974	CD209	-0.272664628543972
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/1010	170/9376	0.873709959231217	TUBA1B/ACTN4/TUBA1C/CDK4/ARPC1B/PRKACA/PPP2CA/HSPA4/SCRIB/PCNA/CDC42/PRKAG1/MYH10/ARHGAP17/STK11/ARPC1A	-0.577358380152514
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/1010	200/9376	0.88190099009901	TUBB/TUBA1B/RPS3/FCGR2A/TUBA1C/CYFIP1/TNF/IL1B/ARPC1B/NFKBIB/NCL/TLR4/TUBB4B/WASF1/CDC42/NAIP/MYH10/CXCL8/ARPC1A	-0.586572835925177
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/1010	68/9376	0.819103086779266	ALDH1A1/ADH5/DHRS4/DGAT1/RDH13/DHRS9	-0.520169423801459
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/1010	130/9376	0.856907844630617	GNAS/ATF6B/COL4A1/ARRB1/PRKACA/HRAS/GNG10/AKT1/ATF4/GNB4/GNG12/PIK3R2	-0.570818384351352
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/1010	110/9376	0.843924392439244	BMP7/E2F5/MYC/TFR2/E2F4/TNF/SKP1/PPP2CA/HDAC2/TGIF2	-0.572100890564886
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1010	36/9376	0.773597359735974	AKR1B1/DCXR/AKR1A1	-0.472875370357695
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/1010	69/9376	0.807232027550581	GNAS/ATF6B/PRKACA/PPP1CC/HDAC2/ATF4	-0.558395568259168
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1010	37/9376	0.752689322986353	COMT/MIF/ADH5	-0.523698024476672
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1010	37/9376	0.752689322986353	TNF/IL1B/HBA1	-0.523698024476672
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/1010	91/9376	0.816102709172016	GNAS/ARRB1/PRKACA/GRK3/GNG10/GNB4/GNG12/GABRA3	-0.612480784961476
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/1010	133/9376	0.83757909625549	HLA-E/HLA-C/HLA-A/TNF/IFNGR2/HLA-B/HRAS/HLA-G/RAC3/ITGB2/PIK3R2/PLCG2	-0.655463724777292
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1010	26/9376	0.714089870525514	FADS2/PLA2G4C	-0.507221677133192
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1010	26/9376	0.714089870525514	HHEX/PKLR	-0.507221677133192
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/1010	49/9376	0.757809658516872	GNAS/ATF6B/PRKACA/ATF4	-0.590569842827677
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/1010	60/9376	0.773597359735974	GNAS/IGF1/PPP2CA/HRAS/PLA2G4C	-0.611265334841366
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	13/1010	144/9376	0.838063806380638	DUSP9/DLX5/MYC/ISL1/IGF1/WNT5B/BMI1/HRAS/AKT1/FZD5/PIK3R2/TBX3/FZD3	-0.68040057175919
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	18/1010	195/9376	0.856907844630617	SLC25A6/PPIF/FCGR2A/SLC25A5/NCF4/GSDMD/FCGR1A/HMGB1/CYBB/TLR4/TLR7/AKT1/ITGB2/HDAC2/PIK3R2/PLCG2/HDAC7/FPR1	-0.701577305940612
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/1010	71/9376	0.784493097197044	CGA/HRAS/AKT1/PIK3R2/GALT/STAT5A	-0.633314696147187
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/1010	38/9376	0.732881709223554	HEXA/HEXB/GALT	-0.573265604994614
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/1010	93/9376	0.798552113275844	ACTN4/CSNK2B/RAC3/LEF1/WASF1/CTNND1/CDC42/CTNNA1	-0.67833997307017
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/1010	125/9376	0.816918811881188	TNF/PPP2R3B/SGPP1/PTEN/PPP2CA/TP53/HRAS/RAC3/AKT1/S1PR2/PIK3R2	-0.715964984890999
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	14/1010	156/9376	0.833104848946433	YWHAE/MYC/SCARB1/TNF/YWHAH/CDK4/PPP2CA/TP53/E2F2/HRAS/AKT1/PIK3R2/EIF3E/IFIT1	-0.730344818645152
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/1010	115/9376	0.807232027550581	GNAS/ALOX5/PRKACA/CYP2J2/HRAS/GNG10/GNB4/GNG12/PLA2G4C/SLC6A4	-0.722673704330527
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/1010	105/9376	0.795700141442716	TNF/IL1B/CARD9/HRAS/CD209/AKT1/LSP1/PIK3R2/PLCG2	-0.731453664340992
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/1010	62/9376	0.748642606196103	MAML1/KAT2A/HDAC2/DTX4/RBPJ	-0.689932792835938
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	16/1010	178/9376	0.834442095894983	NOTUM/MYC/SERPINF1/CSNK2B/WNT5B/PRKACA/SKP1/RUVBL1/TP53/RAC3/CACYBP/LEF1/CSNK1E/FZD5/SIAH1/FZD3	-0.774819626917398
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	13/1010	148/9376	0.815413433235215	MYC/CDK4/IGF1/WNT5B/PTEN/TP53/E2F2/HRAS/AKT1/LEF1/FZD5/PIK3R2/FZD3	-0.786438112020315
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/1010	63/9376	0.736759390224737	WNT5B/TP53/LEF1/FZD5/FZD3	-0.728392988037164
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/1010	52/9376	0.714089870525514	PLTP/SCARB1/CD36/APOE	-0.7183192027859
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/1010	150/9376	0.804541254125413	CCNE1/MYC/WNT5B/TP53/E2F2/HRAS/AKT1/LEF1/RXRB/FZD5/PIK3R2/FZD3/CTNNA1	-0.838458182260154
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	19/1010	212/9376	0.831982066131141	GNAS/FLT1/CSF1R/ANGPT1/IGF1/PGF/HRAS/RAC3/AKT1/ITGB2/MAP2K3/PIK3R2/SIPA1/CTNND1/CDC42/P2RY1/PFN1/FPR1/CRK	-0.859742557604779
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/1010	140/9376	0.795700141442716	SPP1/MEF2C/MYL4/RPS6/TFAM/PRKACA/HRAS/GNG10/AKT1/GNB4/GNG12/PRKAG1	-0.846208759579581
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1010	16/9376	0.58019801980198	MIF	-0.583920798777047
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1010	54/9376	0.687642097543088	TOP3A/CENPX/FAN1/FANCG	-0.799801516713864
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1010	30/9376	0.618877887788779	CYP2J2/PLA2G4C	-0.726439215411795
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/1010	99/9376	0.75015501550155	HRAS/RAC3/AKT1/CHKB/EIF4EBP1/WASF1/PIK3R2/PLA2G4C	-0.868304095822475
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1010	17/9376	0.546068724519511	HSD17B4	-0.650859485141882
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1010	17/9376	0.546068724519511	CDO1	-0.650859485141882
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1010	17/9376	0.546068724519511	CA2	-0.650859485141882
NA	NA	hsa04518	Integrin signaling	13/1010	154/9376	0.783644078693584	SPP1/ICAM4/FLT1/ACTN4/IGF1/COL4A1/PGF/PARVB/RAC3/AKT1/ITGB2/PIK3R2/CDC42	-0.940597850780682
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/1010	67/9376	0.692773754987439	PRKACA/RPS6KA1/PPP1CC/HRAS/ATF4	-0.876862695096165
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/1010	31/9376	0.598914084956883	BAG6/OXA1L	-0.777169950505169
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/1010	101/9376	0.735300460739143	GNAS/WNT5B/PRKACA/HRAS/LEF1/POMC/FZD5/FZD3	-0.929275116539695
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/1010	56/9376	0.663083451202263	ARRB1/PRKACA/GRK3/CSNK1E	-0.878609299440434
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1010	18/9376	0.515731573157316	PRDX1	-0.714526404190879
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1010	32/9376	0.58019801980198	AKR1B1/GALT	-0.826495421466713
Organismal Systems	Immune system	hsa04611	Platelet activation	10/1010	126/9376	0.736759390224737	GNAS/FCGR2A/VAMP8/PRKACA/PPP1CC/AKT1/PIK3R2/PLA2G4C/P2RY1/PLCG2	-1.03360520888019
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/1010	33/9376	0.562616261626163	VAMP8/GOSR2	-0.874508072403778
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/1010	47/9376	0.592542658521171	TNF/PKLR/PIK3R2	-0.972973304396905
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1010	20/9376	0.464158415841584	FDFT1	-0.833477154506065
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/1010	48/9376	0.58019801980198	SLC37A4/AKT1/PIK3R2	-1.0131137922487
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/1010	21/9376	0.442055634134842	CHST13	-0.889336348299524
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/1010	49/9376	0.568357243887654	C1GALT1C1/GALNT4/COLGALT1	-1.05254071270523
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1010	36/9376	0.515731573157316	C1GALT1C1/GALNT4	-1.0114661711927
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/1010	98/9376	0.663083451202263	IMPA2/INPP5D/PTEN/ITPK1/PIP4K2B/PIK3R2/PLCG2	-1.16491863344252
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/1010	37/9376	0.501792881990902	TGDS/GALT	-1.05498916032316
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1010	51/9376	0.546068724519511	GDPD1/ENPP2/PLA2G4C	-1.12937499783704
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/1010	38/9376	0.488587806149036	IGF1/PIK3R2	-1.09754753168497
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/1010	23/9376	0.403616013775291	FNTA	-0.994951289698549
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1010	90/9376	0.618877887788779	GNAS/CA2/SCARB1/PRKACA/EPHX1/ABCG2	-1.26228800911552
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1010	24/9376	0.386798679867987	GLCE	-1.04506631089374
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	11/1010	149/9376	0.685334573725829	GNAS/AGPAT5/LPAR6/DNM1/HRAS/AKT1/AGPAT1/PIK3R2/PLA2G4C/PLCG2/CXCL8	-1.34523852600021
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/1010	115/9376	0.645785622040465	PRKACA/HRAS/GNG10/AKT1/ATF4/GNB4/GNG12/PIK3R2	-1.3279250354429
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/1010	104/9376	0.624828636709825	AGPAT5/CRLS1/AGPAT1/CHKB/PLA2G4C/LYPLA2/LPCAT3	-1.33674027910074
NA	NA	hsa04081	Hormone signaling	17/1010	219/9376	0.720611239206112	SLC40A1/CSH1/GNAS/ADIPOR2/SLC16A10/EPOR/IGF1/PRKACA/CGA/GNG10/ADRB1/GNB4/POMC/GNG12/PIK3R2/STAT5A/STK11	-1.45358949836112
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/1010	69/9376	0.538154685033721	CTSB/GNAS/PRKACA/ADRB1	-1.33783830281298
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/1010	232/9376	0.720245817685217	ACTN4/CYFIP1/ARPC1B/PPP1CC/HRAS/PIP4K2B/RAC3/AKT1/ITGB2/WASF1/GNG12/PIK3R2/CDC42/TMSB4Y/PFN1/MYH10/CRK/ARPC1A	-1.49913197266697
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	11/1010	154/9376	0.663083451202263	GNAS/MYL4/ATF6B/PPP2R3B/SCN1B/PRKACA/PPP2CA/PPP1CC/AKT1/ADRB1/ATF4	-1.46472987555898
NA	NA	hsa04517	IgSF CAM signaling	24/1010	299/9376	0.745137256200537	TUBB/TUBA1B/ACTN4/NRP1/TUBA1C/INPP5D/NRP2/ARPC1B/MTSS1/EPB41L3/PMP22/TUBB4B/PPFIA1/CD209/AKT1/ITGB2/CD86/ESAM/PIK3R2/CDC42/MYH10/PLCG2/ARPC1A/DYNLL2	-1.5561740742661
Human Diseases	Substance dependence	hsa05034	Alcoholism	14/1010	191/9376	0.680441656731118	GNAS/SLC29A1/ATF6B/PRKACA/PPP1CC/HRAS/GNG10/HDAC2/ATF4/GNB4/GNG12/PKIA/SLC29A2/HDAC7	-1.55029611673492
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1010	28/9376	0.331541725601132	B3GALNT1	-1.23078264090026
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	15/1010	203/9376	0.685948397795445	SPP1/FLT1/ACTN4/IGF1/COL4A1/PTEN/PGF/PPP1CC/PARVB/HRAS/RAC3/AKT1/PIK3R2/CDC42/CRK	-1.57174008932399
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/1010	98/9376	0.568357243887654	GNAS/SCARB1/ATF6B/PRKACA/ATF4/POMC	-1.49244283600811
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/1010	45/9376	0.412585258525853	TAP1/ABCG2	-1.37238005671896
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/1010	30/9376	0.309438943894389	PIGW	-1.31624646200869
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	23/1010	298/9376	0.716486145258821	CSH1/BMP7/CCL3/CSF1R/CD4/TNFRSF25/TNF/CCL4/EPOR/CCL3L1/IFNGR2/IL1B/CCL4L2/CXCL3/CD40LG/CSF2RA/TNFRSF14/CCL5/CXCL2/IL10RB/CXCL1/CXCL8/TNFSF13	-1.72812329552114
NA	NA	hsa03272	Virion - Hepatitis viruses	2/1010	48/9376	0.386798679867987	CHMP4A/SCARB1	-1.47984703301736
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/1010	116/9376	0.560191191532946	GNAS/PRKACA/GRK3/GNG10/GNB4/GNG12/PLA2G4C	-1.65605524076074
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/1010	154/9376	0.602803137456603	GNAS/MEF2C/EEF2/EEF2K/PRKACA/PPP1CC/HRAS/PLA2G4C/PRKAG1/TRPM2	-1.72679588794813
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/1010	105/9376	0.53046676096181	GNAS/TNF/IGF1/PRKACA/SSPN/ADRB1	-1.68106728340235
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/1010	194/9376	0.622067979993876	TUBB/TUBA1B/MYL4/TUBA1C/KIF15/DYNLRB1/KIFC1/MYO19/TUBB4B/DNAH14/MYO7A/MYH10/DYNLL2	-1.84813335178593
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/1010	35/9376	0.265233380480905	AKR1B1	-1.51312270879654
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/1010	97/9376	0.47851383076452	GNAS/PRKACA/GNG10/GNB4/GNG12	-1.79376468436371
NA	NA	hsa04082	Neuroactive ligand signaling	13/1010	199/9376	0.606438131250311	GNAS/OGFRL1/PRKACA/GNG10/ADRB1/GNB4/POMC/GNG12/P2RY1/SLC6A4/GLRB/GABRA3/P2RX5	-1.9497394604336
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1010	86/9376	0.431775270550311	SCN9A/PRKACA/P2RY1/GABRA3	-1.83928442861409
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/1010	86/9376	0.431775270550311	GNAS/ATF6B/PRKACA/ATF4	-1.83928442861409
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/1010	72/9376	0.386798679867987	TNF/NFKBIB/CXCL8	-1.81477117904046
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/1010	168/9376	0.552569542668553	CSH1/MYC/EPOR/IFNGR2/CSF2RA/HRAS/AKT1/IL10RB/PIK3R2/STAT5A	-2.03322258143685
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/1010	323/9376	0.66103056126046	CCNE1/IGF2BP1/DNMT1/MYC/HMOX1/FSCN1/MARCKS/PTEN/TP53/E2F2/BMI1/HRAS/STMN1/HDAC2/SOX4/HNRNPK/PIK3R2/PLCG2/CRK/CCNG1/FZD3/UBE2I/DNMT3A	-2.15403591523155
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1010	41/9376	0.226418739434919	GABRA3	-1.72475774146233
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/1010	76/9376	0.366440854611777	GNAS/CA2/PRKACA	-1.92681439024657
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/1010	184/9376	0.554972018941025	BMP7/NRP1/WNT5B/HRAS/RAC3/SEMA6A/PIK3R2/CDC42/PLCG2/SEMA4C/FZD3	-2.1182568361782
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/1010	93/9376	0.399276056637922	GNAS/PRKACA/ADRB1/CST3	-2.02283116586288
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/1010	166/9376	0.503304306334248	SLC25A6/PPIF/MEF2C/SLC25A5/ATF6B/PPP1CC/AKT1/ADRB1/ATF4	-2.2433757374558
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/1010	99/9376	0.375077507750775	TNF/IGF1/SSPN/PRKAG1	-2.17183771241547
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/1010	86/9376	0.323831452912733	LEF1/SSPN/CTNNA1	-2.1886873543513
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/1010	134/9376	0.415664252992463	GNAS/PPP1R14A/PRKACA/PPP1CC/PLA2G4C/MYH10	-2.36711450869767
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/1010	89/9376	0.312915785960619	SPP1/CD36/COL4A1	-2.26284416316742
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/1010	103/9376	0.27038354320869	SLC16A10/COL4A1/COL14A1	-2.5869646754791
NA	NA	hsa04519	Cadherin signaling	24/1010	404/9376	0.551475345554357	YWHAE/ACTN4/KRT7/CYFIP1/YWHAH/PCDH12/SCN1B/ARPC1B/WNT5B/PPP1CC/HRAS/RAC3/LEF1/MAP2K3/WASF1/FZD5/CTNND1/CDC42/MYO7A/MOB1B/GABRA3/ARPC1A/FZD3/CTNNA1	-3.20198848185373
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/1010	102/9376	0.18202290817317	GNAS/CA2	-2.88599168913261
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/1010	254/9376	0.402026974350978	SLC25A6/PPIF/GNAS/FLT1/SLC25A5/PRKACA/TFEB/ADRB1/TPCN1/PLCG2/P2RX5	-3.35691861908924
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	9/1010	226/9376	0.36968369403312	GNAS/PRKACA/CGA/PPP1CC/RAC3/AKT1/ADRB1/POMC/PIK3R2	-3.33264926314105
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/1010	233/9376	0.31873539285259	MYL4/FBLN1/CSRP2/COL4A1/SSPN/PDLIM1/LMNB1/MYH10	-3.65878443434967
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/1010	370/9376	0.426523949692267	CSH1/OGFRL1/NPW/LPAR6/CGA/C3AR1/LTB4R/ADRB1/S1PR2/POMC/P2RY1/NMU/FPR1/GLRB/GABRA3/P2RX5/GAL	-3.91054755118958
NA	NA	hsa04382	Cornified envelope formation	6/1010	217/9376	0.256677464981521	KRT7/BLMH/PPP2R3B/COL4A1/PPP2CA/EPHX2	-3.84920048392894
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1010	449/9376	0.0620256234977618	ARRB1/PRKACA/GRK3	-7.07699310709636