category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	27/589	93/9376	4.62150172517663	AFDN/HEG1/CDH5/BAIAP2/WASF2/ARHGAP29/RASIP1/IGF1R/PARD3/FGFR1/ROCK2/CCM2/NECTIN2/SORBS1/RADIL/PTPRM/FER/FYN/TGFBR1/VCL/CTNNA1/ROCK1/CREBBP/RHOA/CTNNA2/NLK/FARP2	9.08675812258622
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	27/589	138/9376	3.11449029305381	FCGR2A/PXN/PIK3R3/BAIAP2/WASF2/RPS6KA2/PTK2/FN1/ACTR3B/DOCK1/ARHGEF7/ROCK2/GIT2/ARHGEF12/PIP5K1C/GSK3B/PKN2/PKN1/NFATC3/ROCK1/RHOA/VAV2/WIPF1/AKT1/PIK3CA/ELMO1/PLCG1	6.47857114569507
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	34/589	203/9376	2.66615370461749	SPP1/FLT1/VEGFC/PXN/RAPGEF1/COL6A2/PIK3R3/TLN1/PTK2/KDR/SOS1/PAK2/IGF1R/FN1/DOCK1/ITGA6/ROCK2/LAMA2/ITGA2/SOS2/PARVA/PIP5K1C/COL9A3/GSK3B/FYN/PARVB/VCL/ROCK1/RHOA/VAV2/RAF1/AKT1/PIK3CA/PPP1R12A	6.21341494499151
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	37/589	232/9376	2.53872724079386	PXN/PIK3R3/MYH10/BAIAP2/CYRIB/WASF2/EZR/PTK2/KRAS/SOS1/PAK2/FN1/ACTR3B/FGFR1/DOCK1/ITGA6/ARHGEF7/ROCK2/SSH2/LIMK2/ITGA2/SOS2/ARHGEF12/NCKAP1/MRAS/GIT1/PIP5K1C/PIKFYVE/VCL/PIP4K2A/ROCK1/RHOA/VAV2/RAF1/AKT1/PIK3CA/PPP1R12A	6.14413144887038
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	37/589	238/9376	2.47472571371503	IGF2/NTRK2/FLT1/VEGFC/RAPGEF5/RASGRF2/KIT/AFDN/PIK3R3/PLAAT3/GNGT1/PLCG2/TEK/RASA4B/KRAS/ABL1/KDR/SOS1/PAK2/IGF1R/FGFR1/NF1/RASSF1/SOS2/CSF1R/CALM1/GNB4/PLD1/MRAS/KSR1/RHOA/RALGAPB/RAF1/AKT1/PIK3CA/RALGAPA2/PLCG1	5.96619064583057
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	34/589	212/9376	2.55296793413845	ID1/FLT1/VEGFC/RAPGEF1/RAPGEF5/KIT/AFDN/PIK3R3/TLN1/TEK/KRAS/KDR/IGF1R/PARD3/PLCB1/DOCK4/FGFR1/MAGI3/MAGI1/RAPGEF2/SIPA1L2/CSF1R/CALM1/MRAS/PRKD3/PLCB4/RHOA/VAV2/RAF1/AKT1/SIPA1L3/PIK3CA/FARP2/PLCG1	5.92121527821574
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	31/589	184/9376	2.68192219679634	EFNB2/PIK3R3/SEMA3G/PLCG2/BMPR2/PTK2/KRAS/ABL1/ABLIM3/PAK2/EPHB4/PARD3/UNC5B/ROCK2/SSH2/TRPC1/LIMK2/SEMA4C/ARHGEF12/NRP1/PLXNC1/ABLIM1/GSK3B/FYN/NFATC3/RGS3/ROCK1/RHOA/RAF1/PIK3CA/PLCG1	5.96530671091481
NA	NA	hsa04517	IgSF CAM signaling	41/589	299/9376	2.1828051626531	JAM3/PXN/AFDN/PIK3R3/MYH10/CASKIN2/BAIAP2/EZR/TUBB2B/PLCG2/SPTBN1/MTSS1/PTK2/ABL1/KDR/TRIO/PAK2/PARD3/ACTR3B/FGFR1/UNC5B/MAGI1/RAPGEF2/ERC1/TUBB2A/NECTIN2/MPP3/NRP1/SORBS1/IL1RAP/GIT1/GSK3B/FYN/VCL/JAM2/RHOA/SPTAN1/VAV2/AKT1/PIK3CA/PLCG1	5.38146611800135
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	30/589	204/9376	2.34095675621692	IGF2/PXN/PIK3R3/EZR/PLCG2/PTK2/KRAS/KDR/SOS1/ITPR2/IGF1R/FN1/FGFR1/ROCK2/ITGA2/SOS2/ARHGEF12/MRAS/CBL/SDC2/ITPR1/ROCK1/RHOA/VAV2/SMAD2/RAF1/AKT1/PIK3CA/PLCG1/PPP1R12A	5.01326666116444
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	20/589	116/9376	2.74456999004742	JAM3/PXN/AFDN/PIK3R3/CDH5/EZR/PLCG2/PTK2/PECAM1/ROCK2/CLDN5/VCL/CTNNA1/JAM2/ROCK1/RHOA/VAV2/CTNNA2/PIK3CA/PLCG1	4.89479909615704
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	18/589	98/9376	2.92380721388725	FCGR2B/FCGR2A/PLPP3/PIK3R3/WASF2/PLCG2/ASAP2/ACTR3B/DOCK1/LIMK2/PLD1/PIP5K1C/VAV2/RAF1/AKT1/PIK3CA/MARCKSL1/PLCG1	4.95644595574176
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	14/589	65/9376	3.42860127987462	SPP1/GPER1/PIK3R3/KCNJ6/KRAS/ITPR2/PLCB1/TRPC1/GNA11/ITPR1/PLCB4/RAF1/AKT1/PIK3CA	5.086718530335
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	33/589	253/9376	2.07632686203588	PXN/PIK3R3/WASF2/PLCG2/H3-3B/TLN1/PTK2/H3-3A/ITPR2/PLCB1/ACTR3B/DOCK1/NOD1/RPTOR/MALT1/ROCK2/RIPK1/SEPTIN11/TECPR1/BTRC/GSK3B/TNIP1/ITPR1/VCL/ROCK1/PLCB4/RHOA/CYTH3/AKT1/FNBP1/PIK3CA/ELMO1/PLCG1	4.49322922224341
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/589	122/9376	2.60959113807788	SLC2A1/PIK3R3/PLCG2/NOTCH1/KRAS/DIO3/PLCB1/NCOA2/MED13L/GSK3B/MED13/ATP1A1/PLCB4/CREBBP/RHEB/RAF1/AKT1/PIK3CA/PLCG1/NCOA1	4.63290838767016
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/589	86/9376	2.96158250088838	PIK3R3/NRG3/PLCG2/PTK2/KRAS/ABL1/SOS1/PAK2/SOS2/CBL/CDKN1B/GSK3B/RAF1/AKT1/PIK3CA/PLCG1	4.7311957773492
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	42/589	362/9376	1.84689847949047	IGF2/SPP1/NTRK2/FLT1/VEGFC/KIT/COL6A2/PPP2R2A/PIK3R3/GNGT1/PTK2/TEK/KRAS/DDIT4/KDR/SOS1/CDK6/IGF1R/FN1/FGFR1/ITGA6/RPTOR/JAK2/MAGI1/LAMA2/ITGA2/SOS2/CSF1R/GNB4/YWHAH/CCNE1/CDKN1B/COL9A3/GSK3B/PKN2/PKN1/PPP2CB/RHEB/RAF1/PHLPP1/AKT1/PIK3CA	4.25451279346451
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/589	78/9376	3.0612511427452	PXN/PIK3R3/WASF2/PTK2/FN1/ACTR3B/DOCK1/SEPTIN11/CBL/VCL/CTNNA1/RHOA/CTNNA2/PIK3CA/ELMO1	4.73267206216255
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	32/589	250/9376	2.03756876061121	GRK5/AGAP1/ASAP2/IGF1R/PARD3/PSD3/ACTR3B/IQSEC1/EPS15/GIT2/TFRC/ARAP2/PLD1/ACAP2/FOLR2/CBL/GIT1/PIP5K1C/MVB12B/TGFBR1/ARFGEF1/RHOA/RAB31/NEDD4/SMAD2/CYTH3/SNX32/WIPF1/RABEP1/SH3KBP1/NEDD4L/EHD2	4.30496506945544
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	17/589	98/9376	2.76137347978241	PIK3R3/PLCG2/ITPR2/PLCB1/DGKH/INPP4A/CALM1/PIP5K1C/MTMR3/PIKFYVE/ITPR1/PIP4K2A/PLCB4/BPNT2/PIK3CA/PI4KA/PLCG1	4.53795598508964
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/589	149/9376	2.35038342771846	KIT/PLPP3/PIK3R3/PLCG2/KRAS/SOS1/PLCB1/DGKH/SOS2/PLD1/MRAS/PIP5K1C/FYN/AGPAT3/PLCB4/RHOA/CYTH3/RHEB/RAF1/AKT1/PIK3CA/PLCG1	4.30172799525358
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	18/589	110/9376	2.60484642691773	ID1/LRRC32/SMAD6/LTBP1/BMPR2/IGSF1/SMAD7/SKI/ID2/TFRC/SMAD9/TGFBR1/ACVR2B/ROCK1/PPP2CB/CREBBP/RHOA/SMAD2	4.38335501900804
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/589	140/9376	2.38777589134126	SPP1/MEF2A/MEF2C/GNGT1/KRAS/ITPR2/PLCB1/APLNR/KLF2/CALM1/GNB4/HDAC4/MRAS/TGFBR1/ITPR1/PLCB4/NRF1/PDE3B/SMAD2/RAF1/AKT1	4.28316067723184
NA	NA	hsa04518	Integrin signaling	22/589	154/9376	2.27407227746786	SPP1/FLT1/VEGFC/PXN/COL6A2/PIK3R3/TLN1/PTK2/KDR/FERMT2/IGF1R/FN1/ITGA6/LAMA2/ITGA2/PARVA/COL9A3/GSK3B/PARVB/VCL/AKT1/PIK3CA	4.12728861861908
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	13/589	68/9376	3.04324378308199	KIT/PIK3R3/DUSP6/KRAS/PER2/SOS1/SOS2/CSF1R/PPARD/RUNX1T1/RAF1/AKT1/PIK3CA	4.37793619339807
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/589	77/9376	2.89427380768637	PIK3R3/MECOM/KRAS/ABL1/RB1/SOS1/CDK6/SOS2/CBL/CDKN1B/TGFBR1/RAF1/AKT1/PIK3CA	4.32108655215038
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/589	115/9376	2.49159223444305	PDE4D/MEF2A/MEF2C/LRP5/PDE4B/ITPR2/PLCB1/FGFR1/WNK1/PTHLH/PLD1/GNA11/ITPR1/KL/PLCB4/RHOA/OXSR1/RAF1	4.16670797757918
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/589	200/9376	2.06940577249576	FCGR2A/MYO1E/MYH10/BAIAP2/BAIAP2L1/WASF2/EZR/TUBB2B/ABL1/PAK2/ACTR3B/MYO1C/ROCK2/RIPK1/TUBB2A/TNFRSF10A/ARHGEF12/CLDN5/NCKAP1/FYN/SEC24B/ROCK1/RHOA/CYTH3/WIPF1/TNFRSF10B	3.95779952282608
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/589	70/9376	2.95629396070822	SLC2A1/EPAS1/RAPGEF1/PIK3R3/KRAS/SOS1/PAK2/EGLN3/SOS2/CREBBP/RAF1/AKT1/PIK3CA	4.25328596019331
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/589	80/9376	2.78573853989813	PIK3R3/PLCG2/KRAS/KDR/SOS1/IGF1R/JAK2/NF1/SOS2/GSK3B/RAF1/AKT1/PIK3CA/PLCG1	4.15276905868654
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	25/589	193/9376	2.06198263500972	PXN/PIK3R3/PREX1/GRK5/GNGT1/PLCG2/PTK2/KRAS/SOS1/PARD3/PLCB1/JAK2/ROCK2/SOS2/GNB4/GSK3B/ROCK1/PLCB4/RHOA/VAV2/RAF1/AKT1/PIK3CA/ELMO1/PLCG1	3.85946183052957
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	13/589	73/9376	2.83480242807638	PIK3R3/PLCG2/KRAS/RB1/SOS1/CDK6/RASSF1/SOS2/RARB/RAF1/AKT1/PIK3CA/PLCG1	4.07438625579042
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	18/589	122/9376	2.34863202427009	PPP2R2A/PIK3R3/KRAS/SOS1/PAK2/MALT1/SOS2/GSK3B/FYN/NFATC3/PPP2CB/RHOA/VAV2/RAF1/AKT1/PIK3CA/DLG1/PLCG1	3.88178616874268
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	18/589	122/9376	2.34863202427009	PIK3R3/PLCG2/PTK2/KRAS/SOS1/ITPR2/PLCB1/JAK2/SOS2/GNA11/GSK3B/ITPR1/PLCB4/CREBBP/RAF1/AKT1/PIK3CA/PLCG1	3.88178616874268
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/589	76/9376	2.72290233223126	PIK3R3/PLCG2/KRAS/RB1/SOS1/CDK6/IGF1R/SOS2/CALM1/RAF1/AKT1/PIK3CA/PLCG1	3.90435189407606
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/589	106/9376	2.40279334977736	PIK3R3/KRAS/RB1/SOS1/IGF1R/FGFR1/SOS2/CCNE1/FOLR2/CDKN1B/GSK3B/ZEB1/CREBBP/RAF1/AKT1/PIK3CA	3.76036270132633
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	27/589	227/9376	1.89339057463183	PXN/PIK3R3/GNGT1/PTK2/KRAS/RB1/SOS1/ITPR2/CDK6/PLCB1/ROCK2/RIPK1/SOS2/CALM1/ARHGEF12/GNB4/GNA11/GSK3B/NFATC3/ITPR1/ROCK1/PLCB4/RHOA/RHEB/RAF1/AKT1/PIK3CA	3.5276903209395
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	33/589	300/9376	1.75103565365025	IGF2/NTRK2/FLT1/VEGFC/RASGRF2/KIT/MEF2C/DUSP6/RPS6KA2/MECOM/TEK/KRAS/KDR/SOS1/PAK2/IGF1R/TAOK1/FGFR1/MAP3K6/NF1/RAPGEF2/MAP4K3/SOS2/CSF1R/MRAS/IL1RAP/MAP3K11/MAP4K4/NFATC3/TGFBR1/RAF1/AKT1/NLK	3.4229212749276
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	15/589	99/9376	2.41189483973864	GPER1/PIK3R3/PTK2/NOTCH1/KRAS/RB1/SOS1/JAG2/IGF1R/DLL4/SOS2/CDKN1B/RAF1/AKT1/PIK3CA	3.65627743635284
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/589	91/9376	2.44900091419616	FCGR2B/PIK3R3/PLCG2/KRAS/SOS1/MALT1/SOS2/GSK3B/NFATC3/CD81/VAV2/RAF1/AKT1/PIK3CA	3.59601400107626
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	35/589	333/9376	1.67311624017906	SPP1/PXN/COL6A2/PPP2R2A/PIK3R3/PTK2/NOTCH1/KRAS/MAML2/RB1/SOS1/LFNG/CDK6/UBR4/PARD3/FN1/ITGA6/MAGI1/UBE3A/LAMA2/ITGA2/SOS2/CCNE1/CDKN1B/COL9A3/GSK3B/EIF2AK2/PPP2CB/CREBBP/RHEB/RAF1/AKT1/PIK3CA/DLG1/NFX1	3.23801527058644
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	20/589	157/9376	2.02783515188217	SLC2A1/PPARG/MERTK/CD24/PTK2/PECAM1/ABCA1/XKR6/C1QA/DOCK1/JAK2/CD36/VPS8/C1QC/C1QB/PPARD/NFATC3/NR1H3/ELMO1/PROS1	3.362438560716
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/589	157/9376	2.02783515188217	ID1/PPP2R2A/TPTEP2-CSNK1E/BMPR2/WWTR1/PARD3/SMAD7/ID2/RASSF1/TEAD1/YWHAH/BTRC/GSK3B/TGFBR1/CTNNA1/PPP2CB/CSNK1D/SMAD2/CTNNA2/DLG1	3.362438560716
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	25/589	216/9376	1.8424196692448	PPARG/PIK3R3/ERO1A/PTK2/KRAS/ABCA1/PLCB1/JAK2/ROCK2/CD36/CALM1/TNFRSF10A/MIB1/GSK3B/NFATC3/ABCG1/ITPR1/PLCB4/RHOA/VAV2/AKT1/PIK3CA/POU2F1/TNFRSF10B/PLCG1	3.24287799350393
Organismal Systems	Immune system	hsa04611	Platelet activation	17/589	126/9376	2.14773492871965	FCGR2A/PIK3R3/PLCG2/TLN1/ITPR2/PLCB1/ROCK2/ITGA2/ARHGEF12/FYN/ITPR1/ROCK1/PLCB4/RHOA/AKT1/PIK3CA/PPP1R12A	3.35798674255067
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/589	105/9376	2.27407227746786	PIK3R3/PLCG2/KRAS/ITPR2/MALT1/CALM1/ARHGEF12/MRAS/NFATC3/KSR1/ITPR1/RHOA/RAF1/AKT1/PIK3CA	3.3989783426795
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/589	138/9376	2.07632686203588	RAPGEF1/PIK3R3/PHKA2/KRAS/SOS1/PHKB/RPTOR/SOS2/CALM1/SORBS1/CBL/GSK3B/PRKAR2A/PDE3B/RHEB/RAF1/AKT1/PIK3CA	3.2977498996467
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	16/589	117/9376	2.1768897015077	CECR2/MACROH2A1/H2AZ1/H2AX/SMARCC1/H2AZ2/TRRAP/BAZ2B/H2AC6/BICRAL/SMARCA1/BAZ1B/ARID2/RUVBL1/PBRM1/EP400	3.31642074995321
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/589	120/9376	2.12246745897001	NTRK2/RAPGEF1/PIK3R3/RPS6KA2/PLCG2/KRAS/ABL1/SOS1/SOS2/CALM1/GSK3B/RHOA/RAF1/AKT1/PIK3CA/PLCG1	3.20387587200374
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/589	59/9376	2.69805185462289	PIK3R3/KRAS/SOS1/SOS2/GSK3B/CTNNA1/CTNNA2/RAF1/AKT1/PIK3CA	3.38736408805942
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/589	99/9376	2.25110185042273	PLPP3/PIK3R3/WASF2/KRAS/SOS1/DGKH/SOS2/PLD1/PIP5K1C/RHEB/RAF1/AKT1/PIK3CA/PLCG1	3.23988397544303
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/589	89/9376	2.32517502527613	TUBB2B/KRAS/SOS1/ITPR2/PLCB1/GJA1/TUBB2A/SOS2/GNA11/ITPR1/PLCB4/CSNK1D/RAF1	3.25202215286911
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/589	110/9376	2.17070535576478	SLC2A1/EPAS1/FLT1/PIK3R3/PLCG2/TEK/IGF1R/PDK1/TFRC/EGLN3/CDKN1B/CREBBP/AKT1/PIK3CA/PLCG1	3.19757523891362
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/589	69/9376	2.53773283137718	PIK3R3/PLCG2/KRAS/SOS1/SOS2/FYN/VAV2/RAF1/AKT1/PIK3CA/PLCG1	3.31912453533387
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/589	166/9376	1.91789228220181	MEF2A/ADRB2/MEF2C/ITPR2/PLCB1/GTF2I/ROCK2/CALM1/GNA11/NPR1/NFATC3/ITPR1/ROCK1/ATP1A1/PLCB4/RHOA/PDE3B/RAF1/AKT1/PPP1R12A	3.08914945010984
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	21/589	178/9376	1.8780259819538	LRP5/TPTEP2-CSNK1E/PRICKLE2/CCDC88C/PLCB1/RSPO3/ROCK2/SOX17/CCN4/BTRC/PPARD/INVS/RUVBL1/GSK3B/NFATC3/TLE4/PLCB4/CREBBP/RHOA/CTNNBIP1/NLK	3.06191858181485
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/589	60/9376	2.65308432371251	PXN/PIK3R3/PLCG2/PTK2/KRAS/KDR/RAF1/AKT1/PIK3CA/PLCG1	3.3256677970972
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/589	156/9376	1.93879239040529	SCARB1/PPP2R2A/PIK3R3/KRAS/RB1/SOS1/CDK6/RIPK1/SOS2/CLDN5/YWHAH/GSK3B/CD81/EIF2AK2/PPP2CB/RAF1/AKT1/PIK3CA/NR1H3	3.06118355587075
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	14/589	101/9376	2.20652557615694	VEGFC/PIK3R3/PLCG2/KRAS/PLCB1/FN1/JAK2/CDKN1B/TGFBR1/PLCB4/SMAD2/AKT1/PIK3CA/PLCG1	3.15619067768632
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/589	52/9376	2.75512602847068	SCARB1/PLTP/ANGPTL4/CETP/ABCA1/CD36/VAPB/OSBPL5/MYLIP	3.28572958820906
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/589	170/9376	1.87276540497353	JAM3/PPP2R2A/AFDN/CGNL1/MYH10/EZR/PARD3/ACTR3B/MAGI1/ROCK2/AMOTL1/RAPGEF2/CLDN5/JAM2/ROCK1/PPP2CB/RHOA/NEDD4/NEDD4L/DLG1	2.97309968558078
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/589	170/9376	1.87276540497353	IGF2/PIK3R3/LRP5/PLCG2/KRAS/RB1/SOS1/CDK6/IGF1R/SMARCC1/SOS2/ARID2/PBRM1/GSK3B/TGFBR1/SMAD2/RAF1/AKT1/PIK3CA/PLCG1	2.97309968558078
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/589	62/9376	2.56750095843146	NRARP/NOTCH1/MAML2/LFNG/JAG2/NCOR2/DLL4/SPEN/TLE4/CREBBP	3.20596307038038
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/589	125/9376	2.03756876061121	PPP2R2A/PIK3R3/SPTLC2/KRAS/PLCB1/ROCK2/PLD1/ACER2/FYN/ROCK1/PPP2CB/PLCB4/RHOA/RAF1/AKT1/PIK3CA	3.02343423126377
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/589	93/9376	2.22516749730726	PIK3R3/PTK2/RB1/CDK6/FN1/ITGA6/LAMA2/ITGA2/CCNE1/CDKN1B/RARB/AKT1/PIK3CA	3.07408405476942
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	18/589	148/9376	1.93603450649291	KIT/PIK3R3/LRP5/NOTCH1/KRAS/RB1/SOS1/JAG2/CDK6/IGF1R/DLL4/FGFR1/SOS2/GSK3B/RAF1/AKT1/PIK3CA/NCOA1	2.97161058237394
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	22/589	195/9376	1.79593400374385	FCGR2A/PIK3R3/MACROH2A1/PLCG2/H3-3B/H3-3A/H2BC15/PLCB1/H2AZ1/H2AX/H2AZ2/H4C3/H2AC6/H2BC5/HDAC4/H2BC6/PLCB4/HDAC7/RAF1/AKT1/PIK3CA/PLCG1	2.90785229942693
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/589	115/9376	2.07632686203588	PIK3R3/KCNJ6/GNGT1/KRAS/KCNQ1/ITPR2/PLCB1/JAK2/GNB4/GNA11/FYN/ITPR1/PLCB4/AKT1/PIK3CA	3.00667945231172
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/589	76/9376	2.30399428111876	PPARG/FABP4/PLTP/ANGPTL4/SCD/CD36/SORBS1/ME3/PPARD/ACSL3/NR1H3	2.95504419844676
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/589	87/9376	2.19565599203794	PIK3R3/KRAS/SOS1/MSH3/SOS2/GSK3B/TGFBR1/RHOA/SMAD2/RAF1/AKT1/PIK3CA	2.90071033241139
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	23/589	214/9376	1.71086746108564	PXN/PIK3R3/GNGT1/PLCG2/PTK2/KRAS/ITPR2/PAK2/RIPK1/LIMK2/CALM1/GNB4/TNFRSF1B/GNA11/BTRC/NFATC3/CUL4A/ITPR1/RAF1/CUL5/AKT1/PIK3CA/PLCG1	2.72347473533032
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/589	191/9376	1.75020222401977	NTRK2/MACROH2A1/GNGT1/H3-3B/H3-3A/KRAS/H2BC15/SOS1/H2AZ1/H2AX/H2AZ2/H4C3/SOS2/H2AC6/H2BC5/CALM1/GNB4/HDAC4/H2BC6/HDAC7/RAF1	2.71192967291599
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/589	144/9376	1.87926806262969	ID1/PIK3R3/BMPR2/KRAS/IGF1R/FGFR1/JAK2/ID2/SMAD9/LIFR/GSK3B/PCGF3/ACVR2B/SMAD2/RAF1/AKT1/PIK3CA	2.75281875983171
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	11/589	78/9376	2.24491750467981	PLCG2/PLCB1/INPP4A/PIP5K1C/MTMR3/PIKFYVE/PIP4K2A/PLCB4/PIK3CA/PI4KA/PLCG1	2.85835441005433
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/589	14/9376	4.54814455493573	FUT8/B3GNT2/ST3GAL2/ST3GAL1	3.43956861066794
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	18/589	157/9376	1.82505163669395	PIK3R3/HIPK2/KRAS/RB1/ITPR2/CDK6/CALM1/MRAS/CCNE1/BTRC/NFATC3/TGFBR1/ITPR1/SMAD2/RHEB/RAF1/AKT1/PIK3CA	2.69905678232692
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/589	134/9376	1.90071712743583	MYH10/ITPR2/PLCB1/PPP1R14A/PRKCH/ROCK2/CALM1/ARHGEF12/GNA11/NPR1/ITPR1/ROCK1/PLCB4/RHOA/RAF1/PPP1R12A	2.71882221972363
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/589	59/9376	2.4282466691606	FABP4/ADRB2/PIK3R3/PLAAT3/MGLL/NPR1/PDE3B/AKT1/PIK3CA	2.84914236443006
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/589	60/9376	2.38777589134126	KRAS/ITPR2/IGF1R/PLCB1/GNA11/ITPR1/PPP2CB/PLCB4/RAF1	2.79192145568016
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/589	15/9376	4.24493491794001	ST3GAL5/ST6GALNAC3/ST3GAL2/ST3GAL1	3.25621798045159
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/589	103/9376	2.00913181795704	PPP2R2A/PIK3R3/PLCB1/C1QA/C1QC/GNA11/C1QB/TGFBR1/PPP2CB/PLCB4/SMAD2/AKT1/PIK3CA	2.66611792371054
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	17/589	150/9376	1.8040973401245	PIK3R3/LRP5/KRAS/RB1/SOS1/SOS2/CCNE1/CDKN1B/GSK3B/TGFBR1/CTNNA1/RARB/SMAD2/CTNNA2/RAF1/AKT1/PIK3CA	2.57022120493294
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/589	139/9376	1.83234600774389	GPER1/PIK3R3/KCNJ6/KRAS/SOS1/ITPR2/PLCB1/SOS2/NCOA2/CALM1/ITPR1/PLCB4/RAF1/AKT1/PIK3CA/NCOA1	2.55958055111297
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	11/589	83/9376	2.10968151042199	AUTS2/BCOR/CBX2/DCAF7/FOXK1/MBD5/FOXK2/PCGF3/CREBBP/ASXL2/KDM2A	2.62895044506311
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/589	201/9376	1.66312748650635	FLT1/PPARG/MEF2C/DUSP6/H3-3B/PTK2/H3-3A/KLF3/PER2/IGF1R/ID2/NSD2/FLI1/CSF1R/FUT8/CDKN1B/MLLT3/HOXA11/ZEB1/HPGD/RUNX1T1	2.46045255168392
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/589	63/9376	2.27407227746786	MECOM/NSD1/KMT2D/NSD2/PLOD2/EHMT1/SETD2/KMT2C/PRDM16	2.626893776712
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	21/589	205/9376	1.63067621847696	PXN/PIK3R3/KRAS/H2BC15/RB1/CDK6/UBR4/UBE3A/H4C3/H2BC5/HDAC4/YWHAH/CCNE1/CDKN1B/H2BC6/EIF2AK2/CREBBP/RHOA/HDAC7/PIK3CA/DLG1	2.36373078331024
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	18/589	169/9376	1.69546217136657	PIK3R3/TAX1BP1/KRAS/DDIT4/IGF1R/RPTOR/DAPK1/BIRC6/AMBRA1/MRAS/MTMR3/WDFY3/ITPR1/PPP2CB/RHEB/RAF1/AKT1/PIK3CA	2.36200474262506
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/589	133/9376	1.79532021905358	PIK3R3/TPTEP2-CSNK1E/KRAS/SOS1/IGF1R/KLF2/SOS2/PLK2/CDKN1B/TGFBR1/CREBBP/RAF1/AKT1/NLK/PIK3CA	2.39157684413145
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	17/589	158/9376	1.71275063935871	PIK3R3/LRP5/RPS6KA2/KRAS/DDIT4/SOS1/IGF1R/RPTOR/SOS2/GRB10/GSK3B/RHOA/RHEB/RAF1/MAPKAP1/AKT1/PIK3CA	2.3392184438183
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	20/589	196/9376	1.62433734104847	PIK3R3/PREX1/GNGT1/PLCG2/KRAS/RB1/ITPR2/CDK6/JAK2/CALM1/GNB4/GSK3B/NFATC3/ITPR1/EIF2AK2/CREBBP/RAF1/AKT1/PIK3CA/PLCG1	2.2869094965768
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/589	77/9376	2.06733843406169	PIK3R3/KRAS/RB1/CDK6/PLD1/TGFBR1/SMAD2/RAF1/AKT1/PIK3CA	2.43473870319218
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/589	67/9376	2.1383067683653	RPS6KA2/KRAS/ITPR2/PLCB1/CALM1/ITPR1/PLCB4/CREBBP/RAF1	2.42085165060243
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/589	69/9376	2.07632686203588	AQP1/ADRB2/ITPR2/PLCB1/CALM1/NPR1/ITPR1/PLCB4/PDE3B	2.32320128888886
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/589	93/9376	1.88283403618307	KRAS/SOS1/ITPR2/PLCB1/SOS2/CALM1/PLD1/GNA11/ITPR1/PLCB4/RAF1	2.21513061650988
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	29/589	323/9376	1.42921570379559	PIK3R3/ZFPM2/EZR/CYP1B1/PLCG2/BMPR2/NOTCH1/KRAS/ABL1/DDIT4/DICER1/IGF2BP1/SOS1/CDK6/RPTOR/ST14/RASSF1/SOS2/HDAC4/CCNE1/CDKN1B/ZEB1/ROCK1/CREBBP/RHOA/RAF1/PIK3CA/PLCG1/FSCN1	2.03237374819723
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/589	29/9376	2.74456999004742	TPTEP2-CSNK1E/RASSF4/WWTR1/RASSF1/TEAD1	2.43598296827073
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/589	71/9376	2.01783878141515	PIK3R3/KRAS/SOS1/JAK2/SOS2/GSK3B/RAF1/AKT1/PIK3CA	2.22880951044699
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/589	71/9376	2.01783878141515	SLC2A1/KIT/PIK3R3/KRAS/FGFR1/PDK1/RAF1/AKT1/PIK3CA	2.22880951044699
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/589	142/9376	1.68153231784596	UBE3A/BIRC6/COP1/HUWE1/CBL/FBXW7/BTRC/UBE3C/HERC4/CUL4A/NEDD4/CUL5/NEDD4L/UBR5/UBE2G1	2.11864730092479
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/589	142/9376	1.68153231784596	MEF2A/PIK3R3/MEF2C/CDH5/BMPR2/PTK2/PECAM1/KDR/KLF2/CALM1/SDC2/ACVR2B/RHOA/AKT1/PIK3CA	2.11864730092479
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	14/589	130/9376	1.71430063993731	VEGFC/PIK3R3/GNGT1/KRAS/SOS1/PLCB1/SOS2/GNB4/TGFBR1/PLCB4/SMAD2/RAF1/AKT1/PIK3CA	2.12323831758283
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	15/589	143/9376	1.66977335058829	FCGR2A/MACROH2A1/H3-3B/H3-3A/H2BC15/H2AZ1/C1QA/H2AX/H2AZ2/H4C3/H2AC6/H2BC5/C1QC/C1QB/H2BC6	2.08952435180868
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/589	107/9376	1.78525300287197	SLC2A1/PHKA2/ITPR2/PHKB/PLCB1/CALM1/ITPR1/PLCB4/CREBBP/PDE3B/AKT1/SIK1	2.11498857653097
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/589	73/9376	1.9625555271298	PIK3R3/KRAS/RB1/CDK6/IGF1R/FGFR1/RAF1/AKT1/PIK3CA	2.1374633857905
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	14/589	133/9376	1.67563220445	PIK3R3/PLCG2/KRAS/SOS1/ULBP1/SOS2/ULBP2/TNFRSF10A/FYN/VAV2/RAF1/PIK3CA/TNFRSF10B/PLCG1	2.03166761840273
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/589	99/9376	1.768722882475	PIK3R3/PLCG2/ITPR2/PLCB1/PRKCH/CALM1/IL1RAP/ITPR1/PLCB4/PIK3CA/PLCG1	1.99070359271358
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/589	226/9376	1.47915320702556	PDE4D/PDE10A/AFDN/ADRB2/PIK3R3/GLI3/PDE4B/ROCK2/CALM1/PLD1/NPR1/ROCK1/ATP1A1/CREBBP/RHOA/VAV2/PDE3B/RAF1/AKT1/PIK3CA/PPP1R12A	1.88773507029373
NA	NA	hsa04519	Cadherin signaling	34/589	404/9376	1.33967624266671	AFDN/MYO1E/CDH5/LRP5/TMC6/PTK2/PRICKLE2/KRAS/KDR/WWTR1/IGF1R/LIMA1/TAOK1/ACTR3B/GJA1/FGFR1/MYO1C/ROCK2/AMOTL1/TEAD1/NCKAP1/YWHAH/MRAS/KRT7/RERE/GSK3B/VCL/CTNNA1/ROCK1/CREBBP/RHOA/VAV2/CTNNA2/RAF1	1.80690032242815
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/589	23/9376	2.76843581604783	AQP1/CA4/GLUD1/ATP1A1	2.19836967839643
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/589	90/9376	1.768722882475	PPARG/PIK3R3/KRAS/IGF1R/RPTOR/EHMT1/KL/RHEB/AKT1/PIK3CA	1.89714137749828
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/589	34/9376	2.34095675621692	NPAS2/TPTEP2-CSNK1E/PER2/BTRC/CSNK1D	2.02795013596692
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/589	154/9376	1.55050382554627	MEF2C/KCNJ6/KRAS/ITPR2/PLCB1/ROCK2/CALM1/NPR1/NFATC3/ITPR1/ROCK1/PLCB4/RHOA/RAF1/PPP1R12A	1.78332753476044
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/589	233/9376	1.43471512784453	COL6A2/PDLIM4/MYH10/FBLN2/SPTBN1/TLN1/FN1/ITGA6/FMNL2/LAMA2/ITGA2/FMNL3/SDC2/COL9A3/INF2/LBR/VCL/AMPD3/ATP1A1/SPTAN1/CSRP2	1.73964777793178
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	15/589	158/9376	1.51125056414004	ABL1/RB1/STAG1/CDK6/PDS5B/NIPBL/PDS5A/YWHAH/CCNE1/CDKN1B/GSK3B/DDX11/PPP2CB/CREBBP/SMAD2	1.6779034391676
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/589	36/9376	2.21090360309376	GALNT18/ST6GALNAC3/GALNT2/ST3GAL2/ST3GAL1	1.88456168015298
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/589	16/9376	2.98471986417657	FUT9/ST3GAL2/ST3GAL1	2.05704719435597
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/589	48/9376	1.98981324278438	PIK3R3/PLCB1/ATP1A1/PLCB4/AKT1/PIK3CA	1.77992860394249
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/589	37/9376	2.15114945165879	ADSS2/ADSS1/GLUL/GLUD1/NAT8L	1.81637433878828
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/589	17/9376	2.8091481074603	CA4/GLUL/GLUD1	1.93288863117463
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/589	98/9376	1.62433734104847	SCARB1/ITPR2/PLCB1/CALM1/GNA11/NPR1/PRKD3/ITPR1/ATP1A1/PLCB4	1.60852619052484
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/589	38/9376	2.09454025556251	PIK3R3/KRAS/ATP1A1/PIK3CA/NEDD4L	1.75032854228719
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/589	50/9376	1.910220713073	HBA2/HBA1/PECAM1/CD36/SDC2/CD81	1.67073273969919
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/589	76/9376	1.67563220445	EZR/KCNQ1/ITPR2/PLCB1/CALM1/ITPR1/ATP1A1/PLCB4	1.53108265500281
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	14/589	155/9376	1.43780053672162	SCARB1/PDE8A/RB1/ITPR2/CDK6/PLCB1/KMT2D/GNA11/CCNE1/CDKN1B/GSK3B/RASD1/ITPR1/PLCB4	1.42290563779027
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/589	142/9376	1.45732800879983	FCGR2B/FCGR2C/FCGR2A/PPARG/PIK3R3/PLCG2/ITPR2/CSF1R/FYN/TGFBR1/ITPR1/AKT1/PIK3CA	1.42167396337625
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/589	65/9376	1.71430063993731	SCARB1/PDE8A/ITPR2/PLCB1/GNA11/ITPR1/PLCB4	1.49610655792245
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/589	41/9376	1.94128121247257	KRAS/RB1/DAPK1/RASSF1/RAF1	1.56378531347977
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/589	91/9376	1.57435773055467	PDE4D/PDE10A/GRK5/KCNJ6/GNGT1/PDE8A/PDE4B/GNB4/PDE3B	1.42539484997274
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/589	133/9376	1.43625617524286	PPP2R2A/KCNJ6/GNGT1/ITPR2/PLCB1/CALM1/GNB4/GSK3B/ITPR1/PPP2CB/PLCB4/AKT1	1.31184916694529
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/589	56/9376	1.7055542081009	MGAT4A/MGAT5/FUT8/MAN1C1/MGAT1/MAN1A2	1.3710061917695
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/589	44/9376	1.80892112980398	MGAT4A/FUT8/MAN1C1/MGAT1/MAN1A2	1.39241317952202
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/589	21/9376	2.27407227746786	CHSY1/CHST3/CSGALNACT1	1.51322946754947
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/589	122/9376	1.43527512594283	PPARG/PPP2R2A/PIK3R3/IGF1R/RPTOR/SCD/CD36/PPP2CB/RHEB/AKT1/PIK3CA	1.25285840249648
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/589	163/9376	1.36723363921381	PIK3R3/KRAS/RB1/SOS1/JAK2/SOS2/CCNE1/NFATC3/SLC10A1/TGFBR1/CREBBP/RAF1/AKT1/PIK3CA	1.22449973497372
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	10/589	109/9376	1.46041338919955	SLC2A1/PIK3R3/RPS6KA2/PPARGC1B/CD36/OGA/GSK3B/AKT1/PIK3CA/NR1H3	1.25174130875482
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	20/589	248/9376	1.28375047921573	TUBB2B/SNX9/ACTR3B/PODXL/NOD1/ROCK2/RIPK1/EXOC4/TUBB2A/TNFRSF10A/NCKAP1/PKN1/RHOA/PLEKHM2/CYTH3/RAF1/AKT1/PIK3CA/TNFRSF10B/ELMO1	1.17245882738699
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/589	137/9376	1.39432168837446	PIK3R3/KRAS/ITPR2/RIPK1/DAB2IP/TNFRSF10A/ITPR1/SPTAN1/RAF1/AKT1/PIK3CA/TNFRSF10B	1.20370880427309
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/589	97/9376	1.47697477814923	KCNJ6/GNGT1/PER2/PLCB1/CALM1/GNB4/RASD1/ITPR1/PLCB4	1.22251350896393
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/589	12/9376	2.65308432371251	FCGR2B/CD46	1.48346703611368
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/589	128/9376	1.36799660441426	PDE4D/PDE10A/PDE9A/PDE8A/PDE4B/ADSS2/ADSS1/IMPDH1/NPR1/AMPD3/PDE3B	1.0852951395384
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/589	115/9376	1.38421790802392	KCNJ6/GNGT1/KRAS/ITPR2/PLCB1/TRPC1/GNB4/ITPR1/PLCB4/RAF1	1.07329857686596
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/589	24/9376	1.98981324278438	HS6ST1/HS3ST3A1/EXT2	1.25698357889306
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/589	62/9376	1.54050057505888	PIK3R3/KRAS/IGF1R/RPTOR/AKT1/PIK3CA	1.10546974394969
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	12/589	144/9376	1.32654216185625	PIK3R3/ITPR2/PLCB1/PUM2/AMBRA1/ATXN2/ITPR1/PLCB4/ATXN3/AKT1/PIK3CA/NFYA	1.02234054350326
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/589	89/9376	1.43087693863146	SPP1/COL6A2/FN1/ITGA6/LAMA2/ITGA2/CD36/COL9A3	1.0573858719515
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/589	103/9376	1.3909374124318	PIK3R3/PTK2/PLCB1/FN1/LAMA2/GNA11/VCL/PLCB4/PIK3CA	1.03285341298971
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/589	37/9376	1.72091956132703	HBA2/HBA1/PLCB1/PLCB4	1.13752370696786
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/589	90/9376	1.41497830598	PIK3R3/KRAS/JAK2/NFATC3/RAF1/AKT1/PIK3CA/PLCG1	1.02413045453269
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/589	160/9376	1.29337860780985	JAM3/CDH5/PECAM1/ITGA6/NECTIN2/VSIR/CLDN5/PTPRM/SDC2/SIGLEC1/JAM2/CD58/GLG1	0.969036585727509
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/589	104/9376	1.37756301423534	PLPP3/PLAAT3/GDPD5/DGKH/PLD1/AGPAT3/GPD1L/TAFAZZIN/SAMD8	1.00240304014505
NA	NA	hsa04081	Hormone signaling	17/589	219/9376	1.23568310967432	IGF2/GPER1/ADRB2/PIK3R3/GNGT1/IGF1R/PLCB1/JAK2/PTHLH/GNB4/VIPR1/GNA11/SMAD9/NPR1/PLCB4/RHOA/PIK3CA	0.913685814872998
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/589	110/9376	1.30242321345887	PIK3R3/RPS6KA2/KRAS/IGF1R/STK10/PDE3B/RAF1/AKT1/PIK3CA	0.826015678724765
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/589	56/9376	1.42129517341741	TPTEP2-CSNK1E/GLI3/BTRC/GSK3B/CSNK1D	0.818644810967215
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/589	70/9376	1.36444336648072	SLC2A1/JAK2/CD36/TNFRSF1B/ACSL3/AKT1	0.792356304865788
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/589	43/9376	1.48079125044419	SCARB1/PLPP3/ABCA1/CD36	0.818093840699985
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/589	71/9376	1.34522585427676	JAM3/PLCG2/NOD1/GIT1/JAM2/PLCG1	0.755957310051054
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/589	17/9376	1.87276540497353	MTR/MARS1	0.932460046802929
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/589	17/9376	1.87276540497353	MYH10/TFRC	0.932460046802929
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/589	30/9376	1.5918505942275	ABCG2/FOLR2/MTR	0.840587252013951
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/589	101/9376	1.26087175780396	KIT/KRAS/PLCB1/CALM1/GSK3B/PLCB4/CREBBP/RAF1	0.68242317139692
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/589	116/9376	1.23505649552134	GNGT1/ITPR2/PLCB1/TRPC1/GLUL/GNB4/PLD1/ITPR1/PLCB4	0.659505969028172
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/589	31/9376	1.54050057505888	PCCA/GLUL/AFMID	0.780387540282523
NA	NA	hsa04981	Folate transport and metabolism	3/589	31/9376	1.54050057505888	ABCG2/FOLR2/MTR	0.780387540282523
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/589	102/9376	1.24851026998236	KCNQ1/ITPR2/PLCB1/TRPC1/ITPR1/ATP1A1/PLCB4/RHOA	0.653331884690232
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/589	18/9376	1.768722882475	CBR4/ACSL3	0.845157234519432
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/589	88/9376	1.26624479086279	F13A1/C1QA/C1QC/VSIG4/C1QB/CD46/PROS1	0.649657302572395
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/589	75/9376	1.273480475382	CDK6/COP1/TNFRSF10A/CCNE1/SIVA1/TNFRSF10B	0.615623384313731
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/589	254/9376	1.12808309827146	NTRK2/FLT1/VEGFC/ADRB2/PHKA2/PLCG2/KDR/ITPR2/PHKB/PLCB1/FGFR1/CALM1/GNA11/NFATC3/ITPR1/PLCB4/PTAFR/PLCG1	0.535780152076131
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/589	224/9376	1.13703613873393	SLC2A1/PIK3R3/TLN1/KRAS/RB1/TRRAP/CRTC1/NRP1/CCNE1/NFATC3/TGFBR1/CREBBP/SMAD2/AKT1/PIK3CA/DLG1	0.537432701707119
Cellular Processes	Cell motility	hsa04814	Motor proteins	14/589	194/9376	1.14875816078274	DYNLT5/MYO1E/MYH10/TUBB2B/DNAH8/KIF26A/MYO1C/MYO15B/TUBB2A/MYO9A/KIF1B/KIF1C/HOOK3/DNAH1	0.542045812052641
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	13/589	181/9376	1.14331810635125	FCGR2B/FCGR2C/FCGR2A/MALT1/JAK2/CALM1/ARHGEF12/KSR1/CREBBP/RHOA/RAF1/AKT1/NFYA	0.504066057639705
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/589	136/9376	1.17047837810846	FCGR2B/PIK3R3/CDK6/CCNE1/CDKN1B/GSK3B/CD46/EIF2AK2/AKT1/PIK3CA	0.51847252357057
NA	NA	hsa03272	Virion - Hepatitis viruses	4/589	48/9376	1.32654216185625	SCARB1/CLDN5/SLC10A1/CD81	0.587203433090233
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/589	20/9376	1.5918505942275	SQLE/LBR	0.685969729623202
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/589	168/9376	1.13703613873393	MACROH2A1/H2AZ1/H2AX/JAK2/RIPK1/H2AZ2/H2AC6/GLUL/TNFRSF10A/GLUD1/EIF2AK2/TNFRSF10B	0.464012917565531
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/589	78/9376	1.22450045709808	C1QA/NOD1/CALM1/C1QC/C1QB/RHOA	0.515457344919054
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/589	93/9376	1.19816711393468	NOTCH1/MAML2/JAG2/DLL4/JAK2/NFATC3/PLCG1	0.497223739990793
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/589	93/9376	1.19816711393468	ADRB2/ITPR2/PLCB1/CALM1/ITPR1/ATP1A1/PLCB4	0.497223739990793
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/589	49/9376	1.29946987283878	LFNG/GALNT18/GALNT2/FUT11	0.544130615556316
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/589	51/9376	1.24851026998236	PLPP3/PLAAT3/PEDS1/PLD1	0.460710363213374
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/589	51/9376	1.24851026998236	ERO1A/PLCG2/KCNQ1/PLCG1	0.460710363213374
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	16/589	235/9376	1.08381317053788	PPARG/RPS6KA2/MGLL/KRAS/KDM3A/SOS1/FGFR1/RPTOR/SMARCC1/SOS2/NPR1/ACSL3/SLC25A29/RHEB/PRDM16/KDM3B	0.336877743029628
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/589	52/9376	1.22450045709808	SCARB1/CYP1B1/IGF1R/HSD17B2	0.420281952684825
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/589	23/9376	1.38421790802392	GLUL/GLUD1	0.477627172686622
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/589	23/9376	1.38421790802392	FUT9/LARGE1	0.477627172686622
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/589	53/9376	1.20139667488868	PLCB1/KL/ATP1A1/PLCB4	0.380658350233315
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/589	99/9376	1.12555092521137	FCGR2B/FCGR2C/FCGR2A/C1QA/C1QC/C1QB/PTAFR	0.325129749074314
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/589	100/9376	1.11429541595925	KIT/CD24/ITGA6/TFRC/ITGA2/CD36/CSF1R	0.297489344624691
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/589	86/9376	1.11059343783314	GJA1/ITGA6/LAMA2/ITGA2/CTNNA1/CTNNA2	0.266743410405489
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/589	55/9376	1.15770952307455	PLPP3/SPTLC2/ACER2/SAMD8	0.303690342633256
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/589	10/9376	1.5918505942275	BPNT2	0.484794834378718
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/589	57/9376	1.1170881363	SCD/CBR4/ACSL3/ACADVL	0.229555994258707
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/589	89/9376	1.0731577039736	KCNJ6/GNGT1/PLCL1/GLUL/GNB4/GPHN	0.179531359584451
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/589	105/9376	1.061233729485	TAX1BP1/KRAS/AMBRA1/HUWE1/MRAS/ARIH1/MARCHF5	0.163359743432036
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/589	42/9376	1.13703613873393	CP/TFRC/ACSL3	0.230435206423492
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/589	217/9376	1.02700038337258	ADRB2/PIK3R3/RPS6KA2/CYP1B1/KRAS/RB1/SOS1/DLL4/JAK2/SOS2/PAQR7/RAF1/AKT1/PIK3CA	0.104183451346477
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/589	90/9376	1.061233729485	SLC2A1/AQP1/SCARB1/ABCG2/SLC10A1/ATP1A1	0.151119531567102
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	9/589	138/9376	1.03816343101794	RPS6KA2/ITPR2/IGF1R/CALM1/YWHAH/CCNE1/BTRC/ITPR1/PPP2CB	0.116928653598337
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/589	154/9376	1.03366921703085	PPP2R2A/ADRB2/KCNQ1/PLCB1/CALM1/ATP1A1/PPP2CB/PLCB4/AKT1/CREM	0.109069617718556
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/589	75/9376	1.061233729485	ITPR2/PLCB1/ITPR1/ATP1A1/PLCB4	0.137841342154511
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/589	155/9376	1.02700038337258	SCARB1/FCGR2B/FCGR2C/FCGR2A/TUBB2B/TFRC/TUBB2A/ITGA2/CD36/PIKFYVE	0.0877545697203587
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/589	187/9376	1.02150840271284	ITPR2/PLCB1/NLRP1/NOD1/RIPK1/CARD18/PKN2/PKN1/ITPR1/PLCB4/RHOA/ANTXR2	0.0769161980989851
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/589	205/9376	1.00946623048573	PIK3R3/PLCG2/RB1/CDK6/NCOR2/RIPK1/CCNE1/CDKN1B/EIF2AK2/CD58/NEDD4/AKT1/PIK3CA	0.0354787761857836
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/589	173/9376	1.01215933737009	PIK3R3/CDK6/JAK2/TNFRSF10A/EIF2AK2/CREBBP/NUP98/RAF1/AKT1/PIK3CA/TNFRSF10B	0.0417918139062632
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/589	28/9376	1.13703613873393	FUT9/B3GNT2	0.188008614610626
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/589	45/9376	1.061233729485	ABCG2/ABCA1/ABCG1	0.106599666460678
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/589	29/9376	1.09782799601897	GNGT1/CALM1	0.136599467766717
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/589	46/9376	1.03816343101794	CP/EPRS1/ALAS1	0.0671751242892684
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/589	65/9376	0.979600365678464	PLPP3/MGLL/DGKH/AGPAT3	-0.0427271445400751
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/589	32/9376	0.99490662139219	RPTOR/PPP2CB	-0.00747201106929163
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/589	50/9376	0.955110356536502	AMD1/P4HA2/P4HA1	-0.0823960561770625
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	7/589	119/9376	0.936382702486767	VEGFC/PIK3R3/RIPK1/DAB2IP/TNFRSF1B/AKT1/PIK3CA	-0.180815866693098
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/589	103/9376	0.927291608287867	PPP2R2A/PCF11/SMG6/SMG7/PPP2CB/GSPT1	-0.192094970050917
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/589	86/9376	0.925494531527619	SLC2A1/PLCB1/GNA11/ATP1A1/PLCB4	-0.179701826288882
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/589	34/9376	0.936382702486767	POLR1F/POLR1B	-0.0962094463849653
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/589	70/9376	0.909628910987145	ABL1/LAMA2/FYN/EIF4G3	-0.196480739513505
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/589	105/9376	0.909628910987145	PLCG2/MALT1/RIPK1/CARD10/ERC1/PLCG1	-0.241092581473897
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/589	35/9376	0.909628910987145	FCSK/PMM2	-0.138672333694628
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/589	54/9376	0.884361441237502	AMD1/MTR/PHGDH	-0.220631731494097
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/589	73/9376	0.872246900946578	BICD1/SERINC3/MLLT3/CREBBP	-0.283690201709406
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/589	37/9376	0.860459780663516	FCSK/PMM2	-0.220177556672984
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/589	37/9376	0.860459780663516	PPARG/KRAS	-0.220177556672984
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/589	109/9376	0.876248033519727	JAK2/IL1RAP/NFATC3/TGFBR1/SMAD2/PLCG1	-0.336448617952471
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/589	18/9376	0.884361441237502	MTR	-0.127136536137524
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/589	144/9376	0.884361441237502	C1QA/SCD/RIPK1/C1QC/C1QB/GSK3B/AKT1/ACADVL	-0.362042029559501
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/589	38/9376	0.837816102225002	FCSK/PMM2	-0.259355564066556
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/589	75/9376	0.848986983588002	PIK3R3/MSH3/AKT1/PIK3CA	-0.339940700004709
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/589	19/9376	0.837816102225002	HYAL2	-0.183205788673847
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/589	39/9376	0.816333638065387	MTR/MTHFD1L	-0.29756457005743
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/589	149/9376	0.854684882806714	KCNJ6/GNGT1/MGLL/ITPR2/PLCB1/GNB4/ITPR1/PLCB4	-0.462910085337807
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/589	78/9376	0.816333638065387	FCGR2C/FCGR2A/JAK2/MARCKSL1	-0.421701481135057
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/589	168/9376	0.852777104050449	PIK3R3/SOS1/JAK2/SOS2/LIFR/CREBBP/RAF1/AKT1/PIK3CA	-0.49850591320757
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/589	41/9376	0.776512484989026	ALAS1/PHGDH	-0.371288079576365
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/589	41/9376	0.776512484989026	SYCP3/RAD51B	-0.371288079576365
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	13/589	238/9376	0.869498223737712	FCGR2A/PIK3R3/F13A1/PLCG2/C1QA/RPS4Y1/C1QC/NRP1/C1QB/EIF2AK2/RPS10-NUDT3/PIK3CA/PLCG1	-0.527961552144461
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/589	205/9376	0.854163733487929	SLC2A1/PIK3R3/PLCB1/CD36/PDK4/GSK3B/TGFBR1/PLCB4/SMAD2/AKT1/PIK3CA	-0.54658422559533
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/589	42/9376	0.758024092489288	CYP1B1/AFMID	-0.4068982730534
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	8/589	154/9376	0.826935373624678	ADSS2/ADSS1/EPRS1/ALAS1/PMM2/GPHN/AFMID/MTHFD1L	-0.560633549098198
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/589	100/9376	0.795925297113752	CSF1R/TNFRSF10A/TNFRSF1B/TNFRSF10D/TNFRSF10B	-0.531167843492095
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/589	43/9376	0.740395625222095	ACSL3/ACADVL	-0.441731707530788
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/589	63/9376	0.758024092489288	PTGR3/PLAAT3/HPGD	-0.498908120673837
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/589	227/9376	0.841506922058593	PIK3R3/CYP1B1/PTK2/KRAS/ABL1/SOS1/SOS2/PLD1/PRKD3/RAF1/AKT1/PIK3CA	-0.625834335917662
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/589	44/9376	0.723568451921593	GTF2I/TAF2	-0.47582751469642
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/589	44/9376	0.723568451921593	POLG2/ADPRS	-0.47582751469642
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/589	23/9376	0.692108954011958	PDSS2	-0.38274408016828
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/589	23/9376	0.692108954011958	MSH3	-0.38274408016828
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/589	23/9376	0.692108954011958	PREP	-0.38274408016828
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/589	85/9376	0.749106161989414	ADSS2/ADSS1/IMPDH1/AMPD3	-0.601576967771929
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/589	66/9376	0.723568451921593	CYP1B1/STS/HSD17B2	-0.583455456283985
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/589	47/9376	0.677383231586172	ME3/GLO1	-0.574038857588848
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/589	47/9376	0.677383231586172	PIK3R3/PIK3CA	-0.574038857588848
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/589	180/9376	0.795925297113752	PIK3R3/JAK2/SRSF4/NECTIN2/EIF2AK2/RHEB/AKT1/PIK3CA/POU2F1	-0.715729497959966
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/589	48/9376	0.663271080928127	PCCA/HIBADH	-0.605521737762025
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/589	26/9376	0.61225022854904	PLAAT3	-0.512572605373196
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/589	26/9376	0.61225022854904	SCARB1	-0.512572605373196
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/589	109/9376	0.730206694599773	SPP1/PIK3R3/RIPK1/AKT1/PIK3CA	-0.733496099629294
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/589	27/9376	0.589574294158335	SCD	-0.55291303464466
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/589	28/9376	0.568518069366966	GPHN	-0.591977567066025
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/589	30/9376	0.530616864742501	PLAAT3	-0.666650475062508
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/589	75/9376	0.636740237691002	GLUL/MTR/PHGDH	-0.817722742163929
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/589	31/9376	0.513500191686292	KL	-0.702419953422804
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/589	31/9376	0.513500191686292	IMMP2L	-0.702419953422804
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/589	157/9376	0.70974230315876	PPARG/PIK3R3/GSK3B/MAP3K11/AKT1/PIK3CA/NR1H3	-0.949542998812988
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/589	32/9376	0.497453310696095	PCCA	-0.737238425503446
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/589	32/9376	0.497453310696095	BIRC6	-0.737238425503446
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/589	33/9376	0.482378967947729	VTI1A	-0.771167435760139
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/589	103/9376	0.618194405525244	COL6A2/KCNQ1/COL9A3/ATP1A1	-1.00872722541133
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	14/589	298/9376	0.747849272455875	TNFRSF19/BMPR2/ACVRL1/CSF1R/TNFRSF10A/TNFRSF1B/IL1RAP/LIFR/TGFBR1/TNFRSF25/ACVR2B/TNFRSF10D/TNFRSF10B/IL16	-1.14523929466049
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/589	36/9376	0.442180720618751	KL	-0.868149071227973
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/589	36/9376	0.442180720618751	POLA1	-0.868149071227973
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	24/589	480/9376	0.795925297113752	LRP5/TUBB2B/DNAH8/TPTEP2-CSNK1E/KRAS/ITPR2/PLCB1/TUBB2A/AMBRA1/HIP1/CALM1/VAPB/TNFRSF1B/ATXN2/GSK3B/ITPR1/HTT/PLCB4/ATXN3/RAF1/SPG11/DNAH1/PLCG1/UBE2G1	-1.18832539107978
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/589	63/9376	0.505349394992858	GLI3/GSK3B	-1.01987510357148
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/589	86/9376	0.555296718916571	PLCB1/SCN9A/PLCB4	-1.07259229967762
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/589	174/9376	0.640399664344398	ERO1A/MARCHF6/SEC24B/ATXN3/MAN1C1/MAN1A2/UBE2G1	-1.23958573705104
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/589	112/9376	0.568518069366966	ITGA6/JAK2/LAMA2/AKT1	-1.18931069357505
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	12/589	275/9376	0.694625713844729	PIK3R3/TUBB2B/NOTCH1/ITPR2/C1QA/TUBB2A/C1QC/C1QB/GSK3B/FYN/ITPR1/PIK3CA	-1.33069102241861
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/589	116/9376	0.548913998009484	PCCA/GLUD1/ME3/PHGDH	-1.26562727057586
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/589	99/9376	0.482378967947729	ITGA6/LAMA2/ITGA2	-1.34044409456495
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	13/589	308/9376	0.671884991070051	PPARG/TUBB2B/DNAH8/PLCB1/TUBB2A/AMBRA1/HIP1/ITPR1/HTT/PLCB4/CREBBP/NRF1/DNAH1	-1.51589343330399
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	17/589	388/9376	0.697460311903803	PIK3R3/LRP5/TUBB2B/TPTEP2-CSNK1E/KRAS/ITPR2/PLCB1/TUBB2A/AMBRA1/CALM1/GSK3B/ITPR1/EIF2AK2/PLCB4/RAF1/AKT1/PIK3CA	-1.57575849874526
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/589	78/9376	0.408166819032693	ZCCHC7/PAN3	-1.35886030718917
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/589	105/9376	0.454814455493573	ITGA6/LAMA2/ITGA2	-1.45444955619169
NA	NA	hsa04382	Cornified envelope formation	8/589	217/9376	0.586857361927191	PPP2R2A/SPTLC2/DST/ITGA6/ST14/CLDN5/KRT7/PPP2CB	-1.59414869555222
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/589	108/9376	0.442180720618751	NUP210L/NUP98/POM121	-1.50950778750503
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/589	83/9376	0.383578456440363	FAR2/ACSL3	-1.46036648900398
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/589	83/9376	0.383578456440363	RIPK1/G3BP1	-1.46036648900398
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	15/589	368/9376	0.648852144386211	NRG3/TUBB2B/DNAH8/NUP210L/TUBB2A/AMBRA1/VAPB/TNFRSF1B/ATXN2/NUP98/SETX/SPG11/DNAH1/POM121/ANXA11	-1.77919157580921
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	9/589	250/9376	0.573066213921901	AP3B2/HYAL2/AP3D1/RPTOR/VPS13C/PIKFYVE/SCARB2/OSBPL5/SPG11	-1.77138625005816
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/589	61/9376	0.260959113807788	ATP1A1	-1.49921847681844
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/589	63/9376	0.252674697496429	CUL4A	-1.54084208646911
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/589	94/9376	0.338691615793086	GSK3B/USP25	-1.66828461974877
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/589	95/9376	0.335126440890001	FLT1/TEK	-1.68626742643609
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/589	66/9376	0.241189483973864	SMAD2	-1.60159771537921
NA	NA	hsa04082	Neuroactive ligand signaling	6/589	199/9376	0.479954953033418	ADRB2/GNGT1/PLCB1/GNB4/GNA11/PLCB4	-1.91972981171676
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/589	68/9376	0.234095675621692	CYP26B1	-1.64105736679064
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/589	69/9376	0.230702984670653	CALM1	-1.66049169689116
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/589	70/9376	0.227407227746786	CYP1B1	-1.67973630608244
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/589	72/9376	0.221090360309376	RIPK1	-1.71767679427607
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/589	79/9376	0.201500075218671	CYP1B1	-1.84518528324943
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/589	79/9376	0.201500075218671	STXBP1	-1.84518528324943
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/589	82/9376	0.194128121247257	IMPDH1	-1.89755584338234
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/589	82/9376	0.194128121247257	NFYA	-1.89755584338234
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/589	87/9376	0.182971332669828	ATP1A1	-1.98214495890365
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/589	268/9376	0.415781871626587	TUBB2B/ITPR2/TUBB2A/CALM1/ITPR1/PLCG1/UBE2G1	-2.51219812712552
Genetic Information Processing	Translation	hsa03010	Ribosome	2/589	222/9376	0.143409963443919	RPS4Y1/RPS10-NUDT3	-3.34400581639516
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/589	183/9376	0.0869863712692625	MDN1	-3.22921638617983
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/589	243/9376	0.131016509812963	RBM17/SRSF4	-3.55329206239086
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/589	370/9376	0.215114945165879	ADRB2/APLNR/VIPR1/PTH2R/PTAFR	-3.98808056201031
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/589	449/9376	0.0709064852662585	ANO2/CALM1	-5.2233942197866