category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	134/2751	250/9376	1.82680334423846	TPP1/CLTC/AP2A1/SMPD1/AP2B1/CTSO/SGSH/ATP6V1E1/OSTM1/GNS/SCARB2/AP3D1/GNPTG/OSBPL5/DEPTOR/BLOC1S6/CLCN7/GAA/ATP6AP1/AP1M1/M6PR/HEXA/VPS16/ATP6V0A1/VPS35/AP3S2/MITF/NAGLU/SNAP29/DNASE2/IDS/IGF2R/ARL8A/AP2M1/KXD1/AP2A2/GALC/HGSNAT/CTSB/RRAGA/CD68/MAN2B1/FUCA2/SUMF1/TMEM175/ATP6V1A/TFE3/ARSA/SLC15A4/ACP2/GPR155/ATP6V1D/AKT1S1/LIPA/GLB1/BORCS7/GALNS/OSBP/VPS26A/LAMTOR2/OSBPL1A/VPS13A/VPS29/CD164/MCOLN1/MANBA/VPS11/VPS39/TELO2/LAMP1/RPTOR/AP3M1/SNAPIN/CTSK/DMXL1/PLEKHM1/NAGA/HYAL2/MLST8/GGA1/MTOR/ARSB/SLC11A2/BLOC1S1/VPS26B/HYAL1/ATP6V1C1/LAPTM4B/VPS18/LAMTOR5/RAB7A/STX17/AP5M1/BLOC1S3/ABCA2/PLA2G15/TPCN2/CLTCL1/NPC1/CLTA/WDR7/MEAK7/AP4E1/GGA3/ARSG/RRAGD/HYAL3/FIG4/TTI1/CTSC/CTSD/PSAP/AP5S1/VPS33A/BORCS6/ZFYVE26/SLC29A1/PPT2/ATP6V1G1/ATP6V0E2/TPCN1/AP4M1/CLTB/NPC2/SLC36A1/TLR7/AP4B1/AP4S1/CLN6/CTNS/IDUA/ATP6V0E1/ATP6V1G2/CD63	8.5382720584895
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	97/2751	174/9376	1.89998203370143	SEC61A1/MAP3K5/UBXN6/SEL1L/ERO1A/SIL1/GANAB/WFS1/SEC63/HYOU1/MAGT1/TXNDC5/RPN1/PRKCSH/MAN1B1/AMFR/EDEM3/DERL1/NPLOC4/UGGT1/DNAJC5/ATF6/SAR1B/MBTPS1/SSR1/RAD23A/BCAP29/CAPN1/DNAJC10/RAD23B/SEC23A/TRAM1/STUB1/MAN1A1/DNAJB2/DNAJC3/DERL2/UBXN2A/PDIA4/STT3B/STT3A/BCAP31/DNAJB12/TUSC3/ATF6B/VCP/UBQLN2/ERLEC1/NSFL1C/CUL1/UFD1/HSPBP1/SYVN1/SEC24C/DNAJC1/OS9/MAN1A2/UGGT2/SAR1A/EIF2S1/UBE2J2/SEC24B/RNF185/SEC31A/LMAN1/MBTPS2/CANX/MOGS/UBE4B/CKAP4/SELENOS/PREB/LMAN2/NFE2L2/SEC61G/MAP2K7/BAK1/BAG2/RRBP1/ATXN3/RPN2/TMEM258/MAPK9/UBE2D4/DAD1/SSR3/SSR2/KRTCAP2/UBXN8/MAN1C1/UBQLN4/P4HB/HSPA4L/SEC62/MAPK10/SSR4/HSP90B1	7.72156517446044
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	91/2751	169/9376	1.83519279702486	IRS1/BNIP3/IGF1R/ULK1/AKT1/AKT3/PPP2CB/BCL2L1/PPP2CA/DEPTOR/NBR1/MAP1LC3A/IRS2/YKT6/BAD/MRAS/HRAS/AKT2/VPS16/MAP2K2/MAPK3/SNAP29/MAP2K1/PIK3R2/ATG9A/ATG13/CTSB/MAPK1/PRKAA1/RRAGA/PRKACA/RAB1A/STX7/WDFY3/MAP3K7/CAMKK2/UVRAG/WDR45B/PRKACB/WIPI2/EIF2S1/AKT1S1/STK11/WDR45/DAPK3/RB1CC1/WIPI1/RAF1/RRAS/VPS11/VPS39/LAMP1/RPS6KB1/RPTOR/PDPK1/PIK3CA/PLEKHM1/ZFYVE1/MLST8/MTOR/WDR41/ATG101/ATG9B/VPS18/ATG4A/TSC2/ULK2/ATG2B/RAB7A/STX17/ATG4B/PIK3R1/TRAF6/RHEB/MTMR3/MAPK9/EPG5/ATG4C/SUPT20H/ATG16L1/RRAGD/RAB7B/CTSD/PRKAA2/VPS33A/ATG7/GORASP1/PIK3R4/RUBCN/AMBRA1/MAPK10	7.06007009643375
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	40/2751	56/9376	2.43443942462481	GANAB/MGAT3/MGAT4B/MAGT1/RPN1/MAN1B1/MAN2A1/ALG2/SRD5A3/MAN1A1/STT3B/STT3A/TUSC3/MGAT1/B4GALT3/MAN1A2/DHRSX/DPM3/MOGS/DPM2/ALG5/B4GALT2/ALG1/ALG9/RPN2/TMEM258/DPAGT1/DAD1/ALG8/KRTCAP2/MAN1C1/DOLK/ALG12/ALG10B/ALG6/ST6GAL1/ST6GAL2/ALG10/MGAT4C/DOLPP1	6.93755217670934
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	168/2751	388/9376	1.47572204296844	MAP3K5/IRS1/WNT4/WNT6/UQCRC1/CSNK1E/SLC39A14/LRP1/ATP2A2/PSMD3/ULK1/NCSTN/INSR/AKT1/NDUFS1/AKT3/BACE1/SLC39A7/PSMD2/SDHA/CSF1/KLC1/CSNK2B/IRS2/NDUFV1/WNT5A/CALM3/BAD/TUBA3D/HRAS/WNT5B/AKT2/ATF6/PSMC3/MAP2K2/PSMD1/ADRM1/NDUFS3/NDUFB7/CAPN1/SLC39A6/SDHC/APH1B/MAPK3/MAP2K1/COX7A1/NDUFS2/PIK3R2/NDUFS7/ADAM10/FADD/CYC1/PSMC2/NDUFA3/VDAC1/SLC39A9/WNT9A/EIF2AK2/NDUFA4L2/ATG13/TUBB/PSMB7/ATP5F1B/ARAF/ATP5F1A/MAPK1/PSMB4/RELA/DVL1/NDUFS8/PSMC4/PSENEN/VDAC3/GNAQ/NDUFA6/PSMC5/PPP3CB/NDUFC1/CSNK2A2/TUBB6/NDUFS6/WIPI2/NDUFB3/EIF2S1/TUBA3E/RB1CC1/WIPI1/APP/NDUFB10/DVL3/SLC39A13/PSMC1/NDUFV3/APH1A/RAF1/APBB1/PPID/APC/SLC39A3/KIF5B/UQCRC2/COX7A2L/NDUFS4/ATP5PB/NDUFC2/SDHB/PIK3CA/NDUFA11/PSMB5/CDK5/NDUFAB1/ATP5MC1/MTOR/WNT3/FZD2/SLC11A2/WNT10B/ATP5PO/FZD1/ATG101/NAE1/ULK2/ATG2B/ATP5PD/MAP2K7/PIK3R1/PSEN2/LRP6/NDUFB11/MAPK9/FZD4/FZD3/IKBKG/NDUFB2/CASP7/ATP5F1D/IDE/PSMD8/WNT1/PPP3CC/UQCRQ/CACNA1C/IL1B/KLC2/NDUFA13/TUBB3/UQCR11/SLC39A11/PSMA7/FZD8/LRP5/PIK3R4/CHUK/CASP9/MCU/AMBRA1/KLC4/COX6B1/FZD10/MAPT/KIF5A/GAPDH/APOE/MAPK10/CALM2/IL6/NOX4/DKK1	6.16702342815935
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	115/2751	250/9376	1.56777898945838	EHD2/PIP5K1C/RAB31/TGFBR1/PDGFRA/CLTC/AP2A1/EPN1/AP2B1/TGFBR2/ARF3/IGF1R/SRC/RAB5B/WASHC4/CBLB/EGFR/ARPC1A/SMAD2/DAB2/PDCD6IP/RAB11B/HRAS/AGAP3/STAM2/GRK5/GRK3/VPS35/TFRC/WASL/SPART/RABEP1/HGS/VPS37A/IGF2R/AP2M1/RAB11FIP2/AP2A2/RAB10/RAB5C/RAB22A/RAB11A/CAPZA1/PLD1/SNX5/BIN1/SNX12/CHMP3/ARAP1/VPS4A/GIT2/PML/STAM/LDLR/CAPZB/CHMP4A/SMAP1/TSG101/VPS26A/ARFGEF2/WIPF2/RNF41/ARFGAP2/RAB4A/WASHC1/VPS29/KIF5B/PSD3/EPN2/PSD/ARFGAP1/WASHC3/GBF1/CHMP2A/RUFY1/VPS25/VTA1/SNX4/FOLR2/CHMP7/VPS26B/RAB35/ARRB1/AGAP1/RAB7A/ACAP3/TRAF6/PARD3/ASAP2/SNX3/RAB11FIP5/CLTCL1/PRKCI/EEA1/WASHC5/CLTA/VPS45/ZFYVE9/ARF1/AMPH/RAB11FIP3/VPS37C/RBSN/CYTH3/EPS15L1/RHOA/CLTB/MVB12B/HLA-A/KIF5A/PARD6G/WIPF3/DNM1/VPS37D/HLA-C	5.86336704474154
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	33/2751	48/9376	2.34314794620138	AOX1/BCKDHA/IVD/ACAT1/HMGCL/HIBADH/AUH/ECHS1/DBT/ACADSB/BCAT1/ABAT/OXCT1/MCEE/ALDH6A1/DLD/ALDH3A2/BCAT2/MMUT/ACADM/MCCC2/HIBCH/OXCT2/ALDH1B1/HADH/ACSF3/ACADS/EHHADH/PCCB/BCKDHB/ACAD8/MCCC1/IL4I1	6.01157395776382
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	195/2751	480/9376	1.38458742275536	MAP3K5/UBA1/MFN2/DAXX/WNT4/WNT6/UQCRC1/DCTN1/CSNK1E/MAPK14/ATP2A2/PSMD3/ULK1/NDUFS1/BCL2L1/PSMD2/SDHA/CSF1/KLC1/ACTR1A/DERL1/ACTR1B/SIGMAR1/CSNK2B/MAP1LC3A/NDUFV1/WNT5A/CALM3/BAD/TUBA3D/HRAS/PRNP/WNT5B/ATF6/PSMC3/MAP2K2/PSMD1/PINK1/ADRM1/NDUFS3/NDUFB7/UBE2L6/CAPN1/SDHC/MAPK3/MAP2K1/COX7A1/NDUFS2/DCTN6/NDUFS7/FADD/CYC1/PSMC2/NDUFA3/VDAC1/VAPB/WNT9A/GPX8/NDUFA4L2/ATG13/TUBB/PSMB7/ATP5F1B/ARAF/ATP5F1A/MAPK1/PSMB4/VCP/RELA/DVL1/NDUFS8/PSMC4/RAB1A/VDAC3/UBE2L3/CAT/GNAQ/DCTN5/NDUFA6/TARDBP/PSMC5/PPP3CB/NDUFC1/CSNK2A2/TUBB6/NDUFS6/WIPI2/NDUFB3/DCTN3/EIF2S1/ACTR10/TUBA3E/RB1CC1/WIPI1/APP/NDUFB10/DVL3/UBE2J2/PSMC1/NDUFV3/TOMM40/RAF1/PPID/APC/KIF5B/UQCRC2/TRAP1/HTT/COX7A2L/ATXN1/NDUFS4/ATP5PB/DCTN4/NDUFC2/SDHB/NDUFA11/PSMB5/CDK5/NDUFAB1/PRKCA/ATP5MC1/ZFYVE1/UCHL1/TNFRSF1B/MTOR/CAMK2D/WNT3/FZD2/WNT10B/ATP5PO/WDR41/FZD1/ATG101/GPX7/CCS/ULK2/ATG2B/ATP5PD/MAP2K7/BAK1/PSEN2/LRP6/NDUFB11/SNCAIP/ATXN3/MAPK9/FZD4/FZD3/HTRA2/NDUFB2/CASP7/ATP5F1D/GRIA3/PSMD8/WNT1/PPP3CC/FIG4/ATXN1L/DLG4/UQCRQ/DNAH11/PLCG1/PARK7/CACNA1C/DNAL1/IL1B/KLC2/NDUFA13/TUBB3/MAPK12/UQCR11/MAP3K10/PSMA7/FZD8/LRP5/PIK3R4/SEPTIN5/DNAL4/CASP9/MCU/MAPK11/AMBRA1/KLC4/COX6B1/FZD10/MAPT/KIF5A/RYR1/MAPK10/CALM2/IL6/CAMK2A/NOX4/DKK1/DNAH14	5.5738631409956
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	64/2751	122/9376	1.7879161675933	IRS1/PFKL/FASN/PPP2R1A/G6PC3/GYS1/CREB3L2/IGF1R/ULK1/INSR/AKT1/AKT3/PPP2CB/PPP2CA/PRKAG1/IRS2/RAB14/RAB11B/AKT2/SREBF1/FOXO1/CAB39/PPP2R5E/CAB39L/PFKP/PIK3R2/ELAVL1/SCD5/RAB10/PRKAA1/MAP3K7/CAMKK2/AKT1S1/SCD/STK11/CREB3L1/PFKM/CPT1C/PPP2R1B/RPS6KB1/RPTOR/CREB3/PDPK1/PIK3CA/MTOR/PPP2R5B/TSC2/PPP2R3A/PIK3R1/CREB1/EEF2/PPP2R5D/RHEB/PFKFB4/ACACB/PRKAA2/PRKAB1/EEF2K/LEPR/PRKAB2/IGF1/PCK2/STRADB/PPARGC1A	5.64460000608122
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	112/2751	248/9376	1.53919395879504	AHNAK2/PODXL/PKN1/NCKAP1/DCTN1/MAPK14/AKT1/AKT3/RAB5B/KLC1/ROCK2/FLNA/ACTR1A/ACTR1B/SNX33/ARPC1A/EXOC5/DYNC1I2/TUBA3D/HRAS/AKT2/M6PR/VPS16/DYNLT3/MAP2K2/WASL/MAPK3/ABI1/MAP2K1/DCTN6/ARL8A/FADD/PLEKHM2/SNX18/TUBB/RAB5C/MAPK1/RELA/SNX9/DYNLRB1/TXN2/MAP3K7/DCTN5/CSE1L/KPNA1/PFN2/IRAK1/TUBB6/PIK3C2A/DCTN3/ACTR10/TUBA3E/GSDMD/EXOC7/CYFIP1/RAF1/RRAS/EXOC4/KIF5B/VPS11/FYCO1/VPS39/TAB2/DCTN4/BRK1/PIK3CA/KPNA3/RILP/PLEKHM1/TLR4/TCF7L2/VPS18/RAB7A/MAP2K7/ACTG1/DYNC2LI1/BAK1/DYNC2H1/TRAF6/PAK3/MYL9/MAPK9/IKBKG/ARF1/CASP7/CYTH3/MYL5/RAB7B/RHOA/VPS33A/CD14/IL1B/KLC2/TUBB3/MAPK12/ELMO2/EXOC2/CHUK/MAPK11/KLC4/WASF3/KIF5A/RHOB/GAPDH/ELMO1/TAB1/MAPK10/TNFRSF10A/IL6/HSP90B1/NOD1/TCF7L1	5.54524877369705
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	78/2751	158/9376	1.68253661499386	IRS1/WNT4/WNT6/CASTOR2/IGF1R/ATP6V1E1/ULK1/INSR/AKT1/AKT3/DEPTOR/RNF152/WNT5A/HRAS/WNT5B/AKT2/CAB39/MAPKAP1/MAP2K2/RPS6KA2/CAB39L/MAPK3/MAP2K1/PIK3R2/WNT9A/MAPK1/PRKAA1/DVL1/RRAGA/LPIN1/ATP6V1A/ATP6V1D/AKT1S1/STK11/DVL3/LAMTOR2/RAF1/SOS1/TELO2/RPS6KB1/RPTOR/PDPK1/PIK3CA/PRKCA/MLST8/MTOR/WNT3/FZD2/WNT10B/WDR24/FZD1/ATP6V1C1/PRR5/TSC2/ULK2/LAMTOR5/PIK3R1/RHEB/LRP6/FZD4/FZD3/RRAGD/WNT1/TTI1/RHOA/PRKAA2/ATP6V1G1/NPRL3/FZD8/LRP5/CHUK/IGF1/MIOS/FZD10/STRADB/ATP6V1G2/PRR5L/RPS6KA6	5.57537570054719
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	104/2751	235/9376	1.50831651159733	ZNF516/ADCY1/MAP3K5/CNR1/UQCRC1/PNPLA2/MAPK14/CREB3L2/NDUFS1/SDHA/PRKAG1/NDUFV1/HRAS/NDUFS3/RPS6KA2/NDUFB7/ADCY3/COX20/SDHC/ADCY9/COX7A1/NDUFS2/NPR1/NDUFS7/SMARCA4/CYC1/NDUFA3/NDUFAF8/NDUFA4L2/NDUFAF3/ATP5F1B/ATP5F1A/PRKAA1/NDUFS8/PRKACA/COX16/NDUFA6/SMARCE1/PRKACB/NDUFC1/SMARCD3/SMARCC2/NDUFAF2/NDUFS6/NDUFB3/ATF2/AKT1S1/CREB3L1/NDUFB10/BMP8A/NDUFV3/SMARCD2/COA4/CPT1C/MGLL/SOS1/COA3/UQCRC2/COX7A2L/NDUFS4/RPS6KB1/RPTOR/CREB3/ATP5PB/NDUFC2/SDHB/NDUFA11/NDUFAB1/ATP5MC1/MLST8/MTOR/ATP5MF/ATP5PO/TSC2/ATP5PD/ACTG1/PLIN1/CREB1/RHEB/NDUFB11/NDUFAF1/NDUFB2/ATP5F1D/CPT2/ACTL6A/PRKAA2/UQCRQ/PRKAB1/NDUFA13/PRKAB2/MAPK12/COX15/UQCR11/SIRT6/ADCY2/DPF1/ADCY6/MAPK11/COX10/COX6B1/SLC25A20/GNAS/PPARGC1A/RPS6KA6	5.0852146073076
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	75/2751	157/9376	1.62812827761532	AXL/ITGB5/PBX1/BCAR1/TMEM30A/PTPN11/MAPK14/NFATC4/LRP1/ADAM9/ATP2A2/CRK/RAB5B/SLC16A1/SLC2A1/GAS6/RAB14/VPS16/MAP2K2/STAB1/MAPK3/ATP8A2/MAP2K1/CRKL/ADAM10/RAB5C/MAPK1/MFGE8/ITGAV/BSG/GULP1/PROS1/EPOR/LIPA/SPHK1/DOCK1/NR1H2/ABCA1/CPT1C/VPS11/VPS39/TGFBRAP1/ARNT/CAMK2D/ANO6/VPS18/C1QA/RAB7A/CREB1/SIRPA/PLA2G15/VPS8/SPHK2/C1QB/CASP7/PPARD/ITGB3/RAB7B/ATP11C/SLC66A1/VPS33A/DUSP7/ARG1/XKR8/MAPK12/MAPK11/MEGF10/C1QC/MERTK/ELMO1/ALOX15/ANO5/CAMK2A/ANO7/IL10	5.11439487335148
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	22/2751	30/9376	2.49935780928147	GPAA1/PIGK/PIGP/PIGT/PIGS/MPPE1/DPM2/PIGC/PIGG/PIGQ/PIGM/B3GALT4/PIGN/PGAP3/PIGV/PIGH/PIGU/GPLD1/PIGL/PGAP2/PIGO/PIGB	5.30018485867532
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	59/2751	116/9376	1.73348876270698	H6PD/ENO2/PC/GPI/PFKL/HK1/ALDOC/ACO1/SDHA/DLST/PGD/PGAM1/SDHC/PFKP/ACAT1/ACO2/CAT/G6PD/SHMT2/ESD/PGLS/CS/PDHB/PFKM/ADH5/SUCLG1/TPI1/HK2/ALDOA/GOT2/SDHB/ENO1/SUCLG2/PKM/MDH1/PRPS2/PGK1/RPE/IDH3B/ECHS1/SUCLA2/IDH1/IDH3A/MCEE/ALDH6A1/ME1/DLD/SDSL/MMUT/DLAT/HIBCH/ACADS/ACSS2/TKFC/PCCB/PSPH/IDNK/GAPDH/ME3	5.12218143876495
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	48/2751	90/9376	1.81771477038653	ADCY1/IRS1/CREB3L2/IGF1R/ULK1/INSR/AKT1/AKT3/SESN3/PRKAG1/IRS2/HRAS/AKT2/FOXO1/ADCY3/ADCY9/PIK3R2/ATG13/ATF6B/RELA/PRKAA1/PRKACA/CAT/CAMKK2/APPL1/PRKACB/ATF2/AKT1S1/STK11/CREB3L1/RB1CC1/RPS6KB1/RPTOR/CREB3/PIK3CA/MTOR/ATG101/TSC2/PIK3R1/CREB1/RHEB/PRKAA2/PRKAB1/PRKAB2/ADCY2/IGF1/ADCY6/PPARGC1A	5.02280999312922
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	66/2751	138/9376	1.63001596257487	IRS1/RHOQ/HK1/FASN/G6PC3/GYS1/SHC1/INSR/AKT1/AKT3/CRK/CBLB/PRKAG1/PRKAR1A/IRS2/CALM3/BAD/HRAS/AKT2/SREBF1/FOXO1/MAP2K2/PYGM/MAPK3/MAP2K1/CRKL/PIK3R2/SORBS1/ARAF/MAPK1/PRKAA1/PRKACA/PRKACB/INPPL1/PTPN1/PPP1R3C/EXOC7/SHC3/RAF1/SOS1/HK2/RPS6KB1/RPTOR/PDPK1/PIK3CA/MTOR/TSC2/PIK3R1/INPP5A/RHEB/PRKCI/MAPK9/ACACB/PYGB/PRKAA2/PRKAB1/PRKAB2/PRKAR2B/PCK2/PPP1R3F/PRKAR1B/SHC2/PPARGC1A/PHKA2/MAPK10/CALM2	4.80441052329255
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	98/2751	227/9376	1.47138805752654	MAP3K5/ABL1/PTPN11/UQCRC1/MAPK14/SRC/AKT1/NDUFS1/AKT3/SDHA/EGFR/NDUFV1/BAD/HRAS/VEGFA/AKT2/MAP2K2/NDUFS3/NDUFB7/SDHC/MAPK3/MAP2K1/COX7A1/NDUFS2/PIK3R2/CBR1/NDUFS7/KEAP1/CYC1/NDUFA3/VDAC1/NDUFA4L2/ATP5F1B/ARAF/ATP5F1A/MAPK1/RELA/PLD1/NDUFS8/VDAC3/CAT/NDUFA6/CYP1B1/NDUFC1/NDUFS6/EPHX1/NDUFB3/PTPN1/MGST2/GSTT2B/NDUFB10/NDUFV3/AKR1A1/RAF1/SOS1/UQCRC2/COX7A2L/SLC26A2/NDUFS4/GSTM3/ATP5PB/PDPK1/NDUFC2/SDHB/PIK3CA/NDUFA11/NDUFAB1/ATP5MC1/ARNT/ATP5PO/NFE2L2/ATP5PD/MAP2K7/PIK3R1/NDUFB11/MAPK9/GSTA4/IKBKG/NDUFB2/ATP5F1D/UQCRQ/SLC26A6/MGST1/NQO1/NDUFA13/MAPK12/UQCR11/GSTM5/CHUK/GSTM4/MAPK11/COX6B1/EPHX2/PRKD1/MAPK10/AKR1C2/AS3MT/NOX4	4.63279072546794
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	62/2751	130/9376	1.62545647736487	ADCY1/TGFBR1/EDNRB/GNG4/TGFBR2/MAPK14/CREB3L2/SRC/SHC1/AKT1/AKT3/GNAI1/EGFR/SMAD2/GNG12/HRAS/VEGFA/AKT2/GNB2/MAP2K2/MMP2/ADCY3/GNB1/MAPK3/ADCY9/VEGFB/MAP2K1/PIK3R2/COL4A4/MAPK1/RXFP1/ATF6B/RELA/PRKACA/GNB5/PRKACB/COL4A6/ATF2/CREB3L1/COL4A5/SHC3/RAF1/SOS1/CREB3/PIK3CA/PRKCA/ARRB1/MAP2K7/PIK3R1/GNAO1/CREB1/COL4A3/MAPK9/MAPK12/COL3A1/ADCY2/COL1A2/ADCY6/MAPK11/SHC2/GNAS/MAPK10	4.62732302878727
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	66/2751	142/9376	1.58410001996713	UBA1/TRIP12/CBLB/XIAP/KLHL9/HUWE1/CDC27/FBXW11/CUL4B/HERC2/UBE2L6/UBE3C/STUB1/UBE2Q1/KEAP1/PIAS1/UBE2M/KLHL13/UBE2Z/UBE2R2/CUL1/UBE2L3/SYVN1/UBE2F/UBE2W/PML/UBE2J2/PRPF19/UBE2E3/CDC16/MGRN1/UBE4A/UBA2/UBE3B/UBE4B/CUL5/HERC4/WWP2/ANAPC7/TRIM32/ANAPC11/SAE1/BTRC/FZR1/TRAF6/CUL2/UBE2D4/ANAPC10/CUL7/COP1/PIAS3/ANAPC2/RCHY1/UBE2E2/RHOBTB2/DET1/CDC23/ELOB/UBOX5/ANAPC4/FBXO4/UBE2QL1/FBXW8/RHOBTB1/BIRC7/MID1	4.51933411802274
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	21/2751	31/9376	2.30879093819256	SEC61A1/BAG6/OXA1L/SEC63/SRPRA/SRP72/SPCS3/TMEM208/SRPRB/GET3/SGTA/SRP68/GET1/UBL4A/SEC11C/SEC61G/SPCS2/SPCS1/IMMP2L/IMMP1L/SEC62	4.70326517615539
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	20/2751	29/9376	2.35049323756878	CSNK1E/YAP1/LATS2/WWTR1/MOB1A/NF2/TEAD3/SAV1/LATS1/STK3/WTIP/RASSF1/RASSF4/FRMD6/LIMD1/FAT4/DCHS1/DCHS2/TEAD2/AJUBA	4.69346175726286
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	125/2751	308/9376	1.38320421853682	MAP3K5/CLTC/AP2A1/UQCRC1/DCTN1/AP2B1/CREB3L2/PSMD3/ULK1/NDUFS1/PSMD2/SDHA/KLC1/ACTR1A/ACTR1B/NDUFV1/TUBA3D/PSMC3/PSMD1/ADRM1/NDUFS3/NDUFB7/SDHC/COX7A1/NDUFS2/DCTN6/AP2M1/POLR2E/NDUFS7/CYC1/PSMC2/NDUFA3/VDAC1/AP2A2/GPX8/NDUFA4L2/ATG13/TUBB/PSMB7/ATP5F1B/ATP5F1A/PSMB4/NDUFS8/POLR2K/PSMC4/VDAC3/GNAQ/DCTN5/NDUFA6/PSMC5/NDUFC1/TUBB6/NDUFS6/WIPI2/NDUFB3/DCTN3/ACTR10/CREB3L1/TUBA3E/RB1CC1/WIPI1/SLC1A2/NDUFB10/PSMC1/POLR2B/NDUFV3/POLR2I/TGM2/KIF5B/UQCRC2/HTT/COX7A2L/NDUFS4/CREB3/ATP5PB/DCTN4/NDUFC2/SDHB/NDUFA11/PSMB5/NDUFAB1/TFAM/ATP5MC1/MTOR/HDAC2/ATP5PO/ATG101/GPX7/ULK2/ATG2B/ATP5PD/SP1/MAP2K7/CREB1/CLTCL1/NDUFB11/MAPK9/CLTA/NDUFB2/ATP5F1D/GRIA3/PSMD8/DLG4/UQCRQ/DNAH11/DNAL1/KLC2/NDUFA13/TUBB3/UQCR11/CLTB/MAP3K10/TAF4/PSMA7/PIK3R4/DNAL4/CASP9/POLR2L/AMBRA1/KLC4/COX6B1/KIF5A/PPARGC1A/MAPK10/DNAH14	4.4064401527848
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	88/2751	203/9376	1.47745289218609	PIP5K1C/LAMB2/PDGFRB/ITGB8/TNXB/ITGB5/LAMC1/KDR/ITGA1/LAMA4/PDGFRA/BCAR1/PARVA/COL6A3/IGF1R/SRC/SHC1/AKT1/AKT3/CRK/ILK/XIAP/ROCK2/FLNA/ZYX/EGFR/PPP1R12C/BAD/HRAS/VEGFA/AKT2/ARHGAP5/MAPK3/VEGFB/MAP2K1/VTN/CRKL/PIK3R2/FYN/COL4A4/TLN1/TLN2/MAPK1/VCL/COL6A1/ITGAV/PARVB/COL4A6/SPP1/EMP2/EMP1/ITGA3/ARHGAP35/DOCK1/COL4A5/SHC3/LAMA2/COL6A2/RAF1/SOS1/PDPK1/PIK3CA/PRKCA/LAMC3/THBS2/ACTG1/PIK3R1/LAMB1/COL4A3/PAK3/MYL9/MAPK9/MYL5/ITGB3/CCND2/RHOA/RAC3/RAP1B/PDGFC/IGF1/COL1A2/VAV2/SHC2/LAMA1/MYLK3/PDGFD/MAPK10/ITGA2B	4.43160294932083
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	111/2751	268/9376	1.41161151711454	MAP3K5/UBA1/MFN2/DAXX/UQCRC1/MAOB/SLC39A14/PSMD3/NDUFS1/BCL2L1/SLC39A7/PSMD2/SDHA/KLC1/GNAI1/NDUFV1/CALM3/TUBA3D/ATF6/PSMC3/PSMD1/PINK1/ADRM1/NDUFS3/NDUFB7/UBE2L6/SLC39A6/SDHC/COX7A1/NDUFS2/NDUFS7/KEAP1/CYC1/PSMC2/NDUFA3/VDAC1/SLC39A9/NDUFA4L2/TUBB/PSMB7/MAOA/ATP5F1B/ATP5F1A/PSMB4/NDUFS8/TXN2/PRKACA/PSMC4/VDAC3/UBE2L3/NDUFA6/PSMC5/PRKACB/NDUFC1/TUBB6/NDUFS6/NDUFB3/EIF2S1/TUBA3E/NDUFB10/SLC39A13/UBE2J2/PSMC1/NDUFV3/SLC39A3/KIF5B/UQCRC2/TRAP1/COX7A2L/NDUFS4/ATP5PB/NDUFC2/SDHB/NDUFA11/PSMB5/NDUFAB1/ATP5MC1/UCHL1/CAMK2D/SLC11A2/ATP5PO/NFE2L2/ATP5PD/NDUFB11/SNCAIP/MAPK9/HTRA2/NDUFB2/ATP5F1D/PSMD8/UQCRQ/PLCG1/PARK7/KLC2/NDUFA13/TUBB3/UQCR11/SLC39A11/PSMA7/SEPTIN5/CASP9/MCU/KLC4/COX6B1/MAPT/KIF5A/GNAS/MAPK10/DUSP1/CALM2/CAMK2A	4.40535991925486
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	76/2751	170/9376	1.52367267517694	TGFBR1/WNT4/WNT6/TGFBR2/IGF1R/SHC1/AKT1/AKT3/BCL2L1/EGFR/SMAD2/WNT5A/BAD/HRAS/WNT5B/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/CDK4/SMARCA4/KEAP1/WNT9A/GADD45G/ARAF/MAPK1/DVL1/PHF10/SMARCE1/SMARCD3/SMARCC2/MGST2/GSTT2B/DVL3/SHC3/SMARCD2/POLK/RAF1/SOS1/APC/TXNRD1/RPS6KB1/GSTM3/PIK3CA/PRKCA/MTOR/WNT3/TCF7L2/FZD2/WNT10B/FZD1/NFE2L2/ACTG1/PIK3R1/BAK1/TXNRD2/LRP6/GSTA4/FZD4/FZD3/PLCG2/WNT1/ACTL6A/PLCG1/MGST1/NQO1/GSTM5/FZD8/LRP5/GSTM4/DPF1/SHC2/FZD10/TXNRD3/TCF7L1	4.44003998152722
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	81/2751	184/9376	1.50035560191551	DPYSL2/PLXNA4/ABL1/WNT4/PTPN11/SEMA3B/PTCH1/PLXNB2/NFATC4/SRC/NRP1/ABLIM3/SEMA5A/ILK/ROCK2/GNAI1/ABLIM1/BMPR2/CXCL12/WNT5A/ARHGEF12/HRAS/WNT5B/MAPK3/PIK3R2/NCK1/FYN/SEMA7A/BOC/MAPK1/SSH1/CFL2/SEMA3A/PPP3CB/ABLIM2/SLIT3/GDF7/RAF1/RRAS/TRPC1/PDPK1/PIK3CA/CDK5/PRKCA/LIMK1/CAMK2D/PLXNA1/PLXNA3/TRPC6/PIK3R1/NEO1/PARD3/PAK3/MYL9/FZD3/SEMA4B/LRIG2/PLCG2/MYL5/PPP3CC/TRPC4/UNC5B/RHOA/PLCG1/SMO/RAC3/PLXNB1/EPHB6/EFNA5/NTN1/EPHA2/SEMA3G/SEMA6C/EFNA4/UNC5C/EPHB4/PARD6G/EFNA3/CAMK2A/L1CAM/RGMA	4.4169314812256
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	58/2751	122/9376	1.62029902688143	WNT4/PFKL/NOTCH3/ATP2A2/SRC/TBC1D4/AKT1/ESR1/AKT3/SLC2A1/PLCD1/BAD/HRAS/AKT2/FOXO1/MAP2K2/MAPK3/PFKP/SLC9A1/MAP2K1/PIK3R2/MED16/STAT1/MAPK1/PRKACA/NCOA1/ITGAV/PRKACB/NCOR1/PFKM/RAF1/MED24/THRA/PDPK1/MED14/PIK3CA/PLCD3/PRKCA/MTOR/HDAC2/TSC2/ACTG1/PIK3R1/RXRB/RHEB/KAT2A/HDAC3/DIO3/PLCG2/PLCE1/RCAN1/ITGB3/BMP4/MED12/PLCG1/MED27/CASP9/SLC16A2	4.44379749383995
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	21/2751	32/9376	2.23664122137405	BCKDHA/ECHDC1/SUCLG1/SUCLG2/ECHS1/DBT/SUCLA2/ABAT/MCEE/ALDH6A1/DLD/MMUT/ACACB/LDHA/HIBCH/ACADS/ACSS2/EHHADH/PCCB/BCKDHB/ACSS3	4.51533820640503
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	20/2751	30/9376	2.27214346298316	PC/ACO1/SDHA/DLST/ACLY/SDHC/ACO2/CS/PDHB/SUCLG1/SDHB/SUCLG2/MDH1/IDH3B/SUCLA2/IDH1/IDH3A/DLD/DLAT/PCK2	4.4969889634265
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	33/2751	60/9376	1.87451835696111	KDR/MAPK14/SRC/AKT1/AKT3/BAD/HRAS/VEGFA/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/MAPK1/PPP3CB/SPHK1/RAF1/PIK3CA/PRKCA/PIK3R1/SPHK2/PLCG2/PPP3CC/PLCG1/HSPB1/MAPK12/RAC3/PLA2G4D/CASP9/PLA2G4C/MAPK11/SHC2/PLA2G4B	4.37892803119853
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	49/2751	101/9376	1.65349053989368	ADCY1/WNT4/WNT6/EDNRB/CREB3L2/GNAI1/WNT5A/CALM3/HRAS/WNT5B/MAP2K2/MITF/ADCY3/MAPK3/ADCY9/MAP2K1/WNT9A/MAPK1/DVL1/PRKACA/GNAQ/PRKACB/CREB3L1/DVL3/RAF1/CREB3/PRKCA/CAMK2D/WNT3/TCF7L2/FZD2/WNT10B/FZD1/GNAO1/CREB1/FZD4/FZD3/WNT1/FZD8/ADCY2/ADCY6/FZD10/GNAS/ASIP/MC1R/CALM2/CAMK2A/KITLG/TCF7L1	4.25481836229911
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	131/2751	333/9376	1.34076934076934	LAMB2/PDGFRB/ITGB8/TNXB/ITGB5/LAMC1/ITGA1/LAMA4/WNT4/WNT6/NOTCH3/COL6A3/PPP2R1A/CREB3L2/ATP6V1E1/AKT1/AKT3/PPP2CB/PPP2CA/IFNAR1/EGFR/ATP6AP1/WNT5A/BAD/HRAS/VEGFA/WNT5B/AKT2/FOXO1/ATP6V0A1/PPP2R5E/MAP2K2/MAPK3/MAP2K1/VTN/NFX1/PIK3R2/CDK4/TADA3/STAT1/RBPJ/FADD/WNT9A/BCAP31/COL4A4/EIF2AK2/MAPK1/RELA/DVL1/PRKACA/COL6A1/LFNG/ITGAV/PRKACB/COL4A6/SPP1/ATP6V1A/RBL2/ATP6V1D/CDKN1B/CREB3L1/DVL3/RFNG/ITGA3/PSMC1/COL4A5/LAMA2/COL6A2/RAF1/PPP2R1B/SOS1/APC/RPS6KB1/MAML2/CREB3/PKM/PIK3CA/TUBG2/MTOR/WNT3/HDAC2/LAMC3/TUBG1/TCF7L2/FZD2/PPP2R5B/WNT10B/FZD1/ATP6V1C1/THBS2/TSC2/PPP2R3A/PIK3R1/CREB1/BAK1/LAMB1/PARD3/PPP2R5D/COL4A3/UBR4/RHEB/PRKCI/FZD4/FZD3/IKBKG/ATR/ISG15/WNT1/ITGB3/SCRIB/CCND2/ATP6V1G1/ATP6V0E2/FZD8/MAML3/CHUK/COL1A2/HEYL/MAGI1/HLA-A/FZD10/LAMA1/GNAS/PARD6G/HES6/ATP6V0E1/ATP6V1G2/HLA-C/DLG3/ITGA2B/TCF7L1	4.08003940504721
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	40/2751	80/9376	1.70410759723737	PDGFRB/AXL/KDR/PDGFRA/IGF1R/SRC/SHC1/AKT1/AKT3/BCL2L1/EGFR/GAS6/BAD/HRAS/VEGFA/AKT2/MAP2K2/FGF2/MAPK3/MAP2K1/PIK3R2/ARAF/MAPK1/NF1/SHC3/RAF1/SOS1/RPS6KB1/PIK3CA/PRKCA/MTOR/PIK3R1/PLCG2/PLCG1/PDGFC/IGF1/SHC2/NRG2/PDGFD/IL6	4.07543488289656
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	57/2751	125/9376	1.55414612868048	MAP3K5/CERS6/SPTLC2/SMPD1/PPP2R1A/MAPK14/SGPL1/ABCC1/AKT1/GNA12/AKT3/PPP2CB/PPP2CA/ROCK2/GNAI1/HRAS/AKT2/PPP2R5E/MAP2K2/SPTLC1/MAPK3/MAP2K1/PIK3R2/FYN/BDKRB2/CERS2/MAPK1/S1PR3/RELA/PLD1/DEGS1/GNAQ/SGPP1/ORMDL2/SPHK1/GAB2/RAF1/PPP2R1B/PDPK1/PIK3CA/PRKCA/SPTSSA/PPP2R5B/PRKCE/PPP2R3A/PIK3R1/PPP2R5D/SPHK2/MAPK9/CERS4/S1PR2/CTSD/RHOA/MAPK12/RAC3/MAPK11/MAPK10	4.01904585873193
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	15/2751	21/9376	2.43443942462481	CHST3/CHSY1/CHPF2/CHST15/CHPF/B3GAT3/CHST7/B3GALT6/B4GALT7/CHST11/CHST14/XYLT2/XYLT1/UST/CHSY3	4.24041104021142
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	51/2751	109/9376	1.59466949466249	IRS1/PTPN11/G6PC3/GYS1/CREB3L2/TBC1D4/INSR/AKT1/AKT3/SLC2A1/PRKAG1/IRS2/AKT2/SREBF1/FOXO1/RPS6KA2/PYGM/PIK3R2/GFPT1/RELA/PRKAA1/PTPA/OGA/PTPN1/CREB3L1/PPP1R3C/PPARA/NR1H2/RPS6KB1/CREB3/PDPK1/PIK3CA/MTOR/SLC27A3/GFPT2/PRKCE/PIK3R1/CREB1/MAPK9/ACACB/PYGB/SLC27A1/PRKAA2/PRKAB1/SLC27A4/PRKAB2/PCK2/PPARGC1A/MAPK10/IL6/RPS6KA6	4.02399396020157
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	27/2751	49/9376	1.87799612756771	GALNT15/COLGALT1/POFUT1/C1GALT1/GALNT11/POMT2/PLOD3/LFNG/B4GALT3/FUT11/RFNG/GALNT17/B4GALT2/POGLUT1/EOGT/POFUT2/GXYLT1/GALNT13/GALNT18/XXYLT1/POMT1/FUT10/ST6GAL1/ST6GAL2/C1GALT1C1L/B3GLCT/GXYLT2	3.97061376805372
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	38/2751	77/9376	1.68197632974078	TGFBR1/ABL1/PTPN11/TGFBR2/SHC1/AKT1/AKT3/CRK/BCL2L1/BAD/HRAS/AKT2/MAP2K2/STAT5B/MAPK3/MAP2K1/CTBP2/CRKL/PIK3R2/CDK4/GADD45G/ARAF/MAPK1/RELA/BCR/CDKN1B/GAB2/SHC3/POLK/RAF1/SOS1/PIK3CA/HDAC2/PIK3R1/BAK1/IKBKG/CHUK/SHC2	3.87199272011195
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	32/2751	62/9376	1.75907881005148	ADCY1/IRS1/EIF4EBP2/IGF1R/INSR/AKT1/AKT3/PRKAG1/IRS2/HRAS/AKT2/FOXO1/ADCY3/ADCY9/PIK3R2/PRKAA1/PRKACA/CAT/PRKACB/AKT1S1/RPS6KB1/RPTOR/PIK3CA/MTOR/HDAC2/PIK3R1/PRKAA2/PRKAB1/PRKAB2/ADCY2/IGF1/ADCY6	3.86413764562203
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	64/2751	149/9376	1.46393135870056	PIP5K1C/PDGFRB/ADCY1/PLPP3/PDGFRA/LPAR1/PTPN11/AGPAT1/SHC1/INSR/AKT1/GNA12/AKT3/EGFR/MRAS/HRAS/AKT2/MAP2K2/ADCY3/F2R/MAPK3/ADCY9/MAP2K1/AGPAT2/PIK3R2/RALB/FYN/MAPK1/PLD1/SPHK1/GAB2/PLPP1/SHC3/RAF1/SOS1/RRAS/PIK3CA/PRKCA/MTOR/TSC2/PIK3R1/AGPAT3/AGPAT5/RHEB/SPHK2/ARF1/PLCG2/CYTH3/RHOA/PLCG1/PLA2G4D/DGKH/AVPR1A/DGKQ/PDGFC/ADCY2/PLA2G4C/ADCY6/SHC2/GNAS/PDGFD/PLA2G4B/DNM1/KITLG	3.67836308036727
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	48/2751	105/9376	1.55804123175988	MFN2/BNIP3/ULK1/SRC/FKBP8/RAB5B/BCL2L1/AMFR/HUWE1/NBR1/CSNK2B/MAP1LC3A/BNIP3L/TOMM70/MRAS/HRAS/PINK1/MITF/ATG9A/RAB5C/VCP/RELA/TBC1D17/CSNK2A2/TFE3/EIF2S1/MTX1/TOMM40/RRAS/MTX2/OPA1/MUL1/FUNDC1/ATG9B/RAB7A/SP1/FIS1/RHOT2/TOMM20/MAPK9/RAB7B/SAMM50/NLRX1/MON1A/AMBRA1/USP30/MAPK10/CITED2	3.70540462918862
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	74/2751	178/9376	1.41689845163556	MCC/TBL1X/CCN4/ROR2/TLE2/WNT4/WNT6/APCDD1/CSNK1E/NFATC4/PRICKLE2/ROCK2/CSNK2B/WNT5A/FBXW11/LZTS2/WNT5B/LGR4/NKD2/CTBP2/WNT9A/DAAM1/DVL1/PRKACA/CUL1/MAP3K7/TLE6/PRKACB/PPP3CB/CSNK2A2/CHD8/DVL3/APC/NKD1/PRKCA/CAMK2D/WNT3/TCF7L2/FZD2/WNT10B/FZD1/BTRC/LRP6/VANGL1/MAPK9/FZD4/FZD3/CCAR2/RUVBL1/PPARD/WNT1/CBY1/PPP3CC/CCND2/SENP2/SERPINF1/RHOA/RAC3/FZD8/LRP5/RSPO3/INVS/ZNRF3/APCDD1L/PRICKLE3/FZD10/CELSR3/MAPK10/PRICKLE1/DAAM2/CAMK2A/DKK1/FRZB/TCF7L1	3.61852496096716
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	61/2751	142/9376	1.46409244269689	ASS1/MAP3K5/KDR/MAPK7/MAPK14/SRC/AKT1/SDC2/AKT3/IL1R1/BMPR2/IL1R2/CALM3/VEGFA/AKT2/MMP2/SUMO3/PIK3R2/KEAP1/MEF2A/RELA/PRKAA1/TXN2/MAP3K7/ITGAV/MGST2/GSTT2B/GSTM3/PLAT/PIK3CA/BMPR1A/NFE2L2/MAP2K7/ACTG1/PIK3R1/MAPK9/GSTA4/IKBKG/ACVR1/ITGB3/BMP4/RHOA/PRKAA2/MGST1/NQO1/IL1B/MAPK12/ACVR2A/RAC3/GSTM5/MAP2K5/CHUK/ACVR2B/GSTM4/MAPK11/MAPK10/DUSP1/MEF2C/CALM2/ITGA2B/HSP90B1	3.59080420903703
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	83/2751	205/9376	1.37991151776294	IRS1/TGFBR1/ACE/UQCRC1/TGFBR2/MAPK14/GYS1/ATP2A2/TBC1D4/INSR/AKT1/NDUFS1/AKT3/SDHA/SLC2A1/SMAD2/NDUFV1/AKT2/NDUFS3/NDUFB7/MMP2/SDHC/COX7A1/NDUFS2/PIK3R2/NDUFS7/GFPT1/CYC1/NDUFA3/VDAC1/NDUFA4L2/ATP5F1B/ATP5F1A/RELA/NDUFS8/PTPA/VDAC3/G6PD/NDUFA6/NDUFC1/NDUFS6/NDUFB3/PDHB/PPARA/NDUFB10/NDUFV3/UQCRC2/COX7A2L/NDUFS4/ATP5PB/NDUFC2/SDHB/PIK3CA/NDUFA11/NDUFAB1/PRKCA/ATP5MC1/MTOR/CAMK2D/GFPT2/ATP5PO/PDK3/ATP5PD/SP1/PIK3R1/NDUFB11/MAPK9/NDUFB2/ATP5F1D/CPT2/CTSD/REN/UQCRQ/NDUFA13/MAPK12/UQCR11/COL3A1/COL1A2/MAPK11/COX6B1/GAPDH/MAPK10/CAMK2A	3.54396183357246
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	19/2751	32/9376	2.02362777171937	PPP2CB/PPP2CA/ATG9A/ATG13/WIPI2/WIPI1/RPTOR/MLST8/MTOR/ATG101/ATG9B/ATG4A/ULK2/ATG2B/ATG4B/ATG4C/ATG16L1/ATG7/PIK3R4	3.73756390042227
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	24/2751	44/9376	1.85902646971349	MGAT4B/MAGT1/RPN1/MAN1B1/MAN2A1/ALG2/HEXA/MAN1A1/STT3B/STT3A/TUSC3/MGAT1/B4GALT3/MAN1A2/B4GALT2/ALG1/ALG9/RPN2/TMEM258/DAD1/KRTCAP2/MAN1C1/ALG12/MGAT4C	3.68030245601395
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	24/2751	44/9376	1.85902646971349	DCTN1/CREB3L2/VAMP2/RAB5B/ARHGDIA/DYNC1I2/RAB11B/ADCY3/ADCY9/DCTN6/NSF/RAB5C/RAB11A/PRKACA/DCTN5/PRKACB/CREB3L1/CREB3/DCTN4/DYNC2LI1/CREB1/DYNC2H1/ADCY6/GNAS	3.68030245601395
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	21/2751	37/9376	1.93439240767485	GPI/HK1/UXS1/GFPT1/UGDH/NAGK/PMM1/GMPPA/GALK1/HK2/MPI/GMPPB/GFPT2/GNE/GNPNAT1/GALT/GALK2/TGDS/FPGT/NANP/FCSK	3.66959358052351
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	85/2751	212/9376	1.36650137514317	PDGFRB/ADCY1/CNR1/KDR/PDGFRA/LPAR1/BCAR1/MAPK14/SIPA1L2/IGF1R/SRC/INSR/AKT1/CTNND1/AKT3/CRK/CSF1/GNAI1/EGFR/CALM3/RASGRP2/MRAS/HRAS/VEGFA/AKT2/MAP2K2/FGF2/ADCY3/F2R/MAPK3/ADCY9/VEGFB/MAP2K1/CRKL/PIK3R2/RALB/TLN1/TLN2/MAPK1/GNAQ/PFN2/RAF1/RRAS/MAGI3/CSF1R/PIK3CA/PRKCA/ADORA2B/ACTG1/PIK3R1/GNAO1/SIPA1/F2RL3/PARD3/PRKCI/PLCE1/MAGI2/ITGB3/RHOA/PLCG1/FGF7/MAPK12/RAC3/RAP1B/PDGFC/ADCY2/EFNA5/IGF1/SIPA1L3/EPHA2/ADCY6/MAPK11/VAV2/EFNA4/MAGI1/FGF10/GNAS/PDGFD/PARD6G/P2RY1/PRKD1/EFNA3/CALM2/KITLG/ITGA2B	3.47807538474571
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	45/2751	99/9376	1.54918872476124	ADCY1/NOTCH3/MAPK14/IGF1R/SRC/SHC1/AKT1/ESR1/AKT3/DLL1/EGFR/BAD/HRAS/AKT2/MAP2K2/MMP2/ADCY3/MAPK3/ADCY9/MAP2K1/PIK3R2/CDK4/ARAF/MAPK1/PRKACA/PRKACB/NCOR1/CDKN1B/SHC3/RAF1/SOS1/RPS6KB1/PIK3CA/MTOR/SP1/PIK3R1/MAPK9/MAPK12/ADCY2/IGF1/ADCY6/MAPK11/SHC2/GNAS/MAPK10	3.53975678895206
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	45/2751	99/9376	1.54918872476124	PIP5K1C/PDGFRB/PLPP3/PDGFRA/SLC44A2/WASF2/AKT1/AKT3/SLC44A1/EGFR/HRAS/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/MAPK1/CHPT1/PLD1/PCYT1A/PLPP1/RAF1/SOS1/RPS6KB1/PDPK1/PIK3CA/PRKCA/MTOR/TSC2/SP1/PIK3R1/RHEB/MAPK9/PLCG1/RAC3/PLA2G4D/DGKH/DGKQ/PDGFC/WASF1/PLA2G4C/WASF3/PDGFD/PLA2G4B/MAPK10	3.53975678895206
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	36/2751	75/9376	1.63594329334787	ASS1/ENO2/PC/MTR/PFKL/PYCR2/ALDOC/ACO1/PGAM1/PFKP/ASL/ACO2/SHMT2/CS/MAT2B/PFKM/TPI1/ALDOA/GOT2/ENO1/PKM/PRPS2/ACY1/PGK1/RPE/IDH3B/BCAT1/IDH1/IDH3A/ALDH18A1/BCAT2/SDSL/PYCR3/ARG1/PSPH/GAPDH	3.56305226766137
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	49/2751	110/9376	1.51820495026602	EGLN2/EGLN1/ENO2/PFKL/HK1/ALDOC/IGF1R/INSR/AKT1/AKT3/SLC2A1/EGFR/LTBR/VEGFA/AKT2/TFRC/MAP2K2/MAPK3/PFKP/MAP2K1/PIK3R2/MAPK1/PDK1/RELA/CDKN1B/PDHB/PFKM/HK2/ALDOA/RPS6KB1/ENO1/PIK3CA/PRKCA/MTOR/ARNT/CAMK2D/TLR4/PGK1/TIMP1/PIK3R1/CUL2/PLCG2/LDHA/PLCG1/ELOB/IGF1/GAPDH/IL6/CAMK2A	3.52281424737034
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	13/2751	19/9376	2.33193671200903	SGSH/GNS/HEXA/NAGLU/IDS/HGSNAT/GLB1/GALNS/HYAL2/ARSB/HYAL1/HYAL3/IDUA	3.74481240983308
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	29/2751	57/9376	1.7340042217503	FADS1/FADS2/FASN/ACADVL/HSD17B4/HSD17B12/HACD3/ELOVL1/ACAT1/SCD5/SCD/CPT1C/ECHS1/ACADSB/ELOVL3/CPT2/ACADM/PPT2/MCAT/HADH/ACSF3/ELOVL6/ELOVL4/ACADS/CBR4/OXSM/EHHADH/HSD17B8/MECR	3.58170094829375
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	65/2751	155/9376	1.42925153316682	KCNK3/ADCY1/PBX1/WNT4/WNT6/PDE8B/CREB3L2/GNA11/SCARB1/GNAI1/EGFR/WNT5A/WNT5B/MAP2K2/ADCY3/MAPK3/ADCY9/MAP2K1/CDK4/WNT9A/MAPK1/ATF6B/DVL1/PRKACA/GNAQ/PDE8A/PRKACB/CDKN1B/ATF2/LDLR/CREB3L1/DVL3/AIP/APC/CREB3/ARNT/CAMK2D/WNT3/TCF7L2/FZD2/WNT10B/FZD1/NCEH1/SP1/CREB1/CRHR1/FZD4/FZD3/WNT1/CACNA1G/ARMC5/STAR/CACNA1C/WDR5/RAP1B/FZD8/KCNA4/ADCY2/CACNA1H/ADCY6/FZD10/GNAS/WDR5B/CAMK2A/TCF7L1	3.47237551491608
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	82/2751	204/9376	1.36996885268102	TWIST2/ITGB5/KDR/WNT4/WNT6/PTPN11/PTCH1/MAPK14/IGF1R/SRC/AKT1/ESR1/SDC2/AKT3/ROCK2/FLNA/EGFR/PPP1R12C/SMAD2/WNT5A/ARHGEF12/MRAS/HRAS/VEGFA/WNT5B/AKT2/MAP2K2/MMP2/FGF2/TIMP3/MAPK3/SLC9A1/MAP2K1/VTN/PIK3R2/CTTN/WNT9A/ARAF/MAPK1/MSN/PRKACA/ITGAV/PRKACB/HSPB2/DCN/RAF1/SOS1/RRAS/RPS6KB1/PDPK1/PIK3CA/PLAU/PRKCA/MTOR/CAMK2D/WNT3/TLR4/FZD2/WNT10B/FZD1/ACTG1/PIK3R1/HOXD10/FZD4/FZD3/PLCG2/PLCE1/WNT1/ITGB3/LUM/RHOA/PLCG1/MAPK12/SMO/FZD8/IGF1/COL1A2/MAPK11/VAV2/FZD10/CAMK2A/CD63	3.44259723456664
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	137/2751	368/9376	1.26881924359521	MAP3K5/DAXX/UQCRC1/DCTN1/MAPK14/PSMD3/ULK1/NDUFS1/BCL2L1/PSMD2/SDHA/KLC1/ACTR1A/DERL1/ACTR1B/SIGMAR1/MAP1LC3A/NDUFV1/BAD/TUBA3D/CHCHD10/ATF6/PSMC3/PSMD1/PINK1/ADRM1/NDUFS3/NDUFB7/SDHC/COX7A1/NDUFS2/DCTN6/NDUFS7/CYC1/PSMC2/NDUFA3/VDAC1/VAPB/GPX8/ANXA11/NDUFA4L2/ATG13/TUBB/PSMB7/ATP5F1B/ATP5F1A/PSMB4/VCP/NDUFS8/UBQLN2/PSMC4/RAB1A/CAT/DCTN5/NDUFA6/TARDBP/PFN2/PSMC5/PPP3CB/NDUFC1/TUBB6/NDUFS6/WIPI2/NDUFB3/ANXA7/DCTN3/EIF2S1/ACTR10/TUBA3E/RB1CC1/WIPI1/SLC1A2/NDUFB10/NUP50/PSMC1/NDUFV3/TOMM40/KIF5B/UQCRC2/COX7A2L/NDUFS4/ATP5PB/DCTN4/NDUFC2/SDHB/NDUFA11/PSMB5/NDUFAB1/ATP5MC1/TNFRSF1B/MTOR/ATP5PO/WDR41/ATG101/GPX7/CCS/ULK2/ATG2B/ATP5PD/ANG/ACTG1/NUP54/NDUFB11/NUP188/NDUFB2/ATP5F1D/PSMD8/PPP3CC/FIG4/NUP43/UBQLN4/UQCRQ/DNAH11/NUP85/DNAL1/KLC2/NDUFA13/TUBB3/MAPK12/UQCR11/PSMA7/NDC1/PIK3R4/DNAL4/CASP9/MCU/NUP133/MAPK11/GLE1/AMBRA1/KLC4/COX6B1/NUP205/KIF5A/NRG2/NXT2/DNAH14	3.3900653286995
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	53/2751	122/9376	1.48061807628821	ADCY1/IRS1/BCAR1/MAPK14/CREB3L2/SHC1/AKT1/GNA11/AKT3/CRK/GNAI1/IRS2/HRAS/AKT2/MAP2K2/ADCY3/STAT5B/MAPK3/ADCY9/MAP2K1/CRKL/PIK3R2/STAT1/MAPK1/ATF6B/PRKACA/GNAQ/PRKACB/ATF2/CREB3L1/SHC3/RAF1/SOS1/CREB3/PIK3CA/PRKCA/MTOR/IGFBP3/PIK3R1/CREB1/MAPK9/PLCG2/GHR/PLCG1/CACNA1C/MAPK12/ADCY2/IGF1/ADCY6/MAPK11/SHC2/GNAS/MAPK10	3.44312873363889
Human Diseases	Cancer: specific types	hsa05214	Glioma	36/2751	76/9376	1.61441772369856	PDGFRB/PDGFRA/IGF1R/SHC1/AKT1/AKT3/EGFR/CALM3/HRAS/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/CDK4/GADD45G/ARAF/MAPK1/CAMK1/SHC3/POLK/RAF1/SOS1/PIK3CA/PRKCA/MTOR/CAMK2D/PIK3R1/BAK1/PLCG2/PLCG1/IGF1/CAMK1D/SHC2/CALM2/CAMK2A	3.46550914287384
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	19/2751	33/9376	1.96230571803091	ACO1/DLST/BCKDHA/ACO2/CS/PDHB/GOT2/DHTKD1/ACY1/IDH3B/DBT/BCAT1/IDH1/IDH3A/DLD/BCAT2/DLAT/BCKDHB/AADAT	3.56832870815621
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	34/2751	71/9376	1.63210305087523	PDGFRB/PDGFRA/PFKL/HK1/SLC16A3/AKT1/AKT3/SLC2A1/EGFR/HRAS/AKT2/MAP2K2/PGAM1/MAPK3/PFKP/MAP2K1/PIK3R2/MAPK1/PDK1/G6PD/PDHB/PFKM/RAF1/HK2/RET/PKM/PIK3CA/MTOR/IDH1/NTRK1/PIK3R1/LDHA/SIRT6/SIRT3	3.44506058783814
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	52/2751	120/9376	1.47689325093905	MAP3K5/IRS1/ABL1/PTPN11/MAPK7/MAPK14/SHC1/AKT1/AKT3/CRK/ARHGDIA/CALM3/BAD/HRAS/AKT2/MAP2K2/RPS6KA2/MAPK3/MAP2K1/CRKL/PIK3R2/KIDINS220/MAGED1/MAPK1/RELA/IRAK1/SHC3/RAF1/SOS1/PDPK1/PIK3CA/CAMK2D/SH2B1/PRDM4/MAP2K7/NTRK1/PIK3R1/TRAF6/PSEN2/MAPK9/PLCG2/RHOA/PLCG1/MAPK12/RAP1B/MAP2K5/MAPK11/SHC2/MAPK10/CALM2/CAMK2A/RPS6KA6	3.387958784889
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	21/2751	38/9376	1.88348734431499	GPI/HK1/UXS1/HEXA/GFPT1/UGDH/NAGK/PMM1/GMPPA/GALK1/HK2/MPI/GMPPB/GFPT2/GNE/GNPNAT1/GNPDA2/GALT/GALK2/FPGT/FCSK	3.51643981200743
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	65/2751	157/9376	1.41104450726661	TGFBR1/DLG5/WNT4/WNT6/TGFBR2/PPP2R1A/CSNK1E/YAP1/PPP2CB/PPP2CA/BMPR2/LATS2/SMAD2/WNT5A/FBXW11/WNT5B/CSNK1D/NKD2/CTNNA1/WWTR1/WNT9A/DVL1/MOB1A/NF2/DVL3/GDF7/BMP8A/TEAD3/PPP2R1B/APC/NKD1/SAV1/LATS1/STK3/BMPR1A/WNT3/TCF7L2/FZD2/WNT10B/FZD1/WTIP/ACTG1/BTRC/SNAI2/RASSF1/PARD3/PRKCI/FZD4/FZD3/FRMD6/WNT1/BMP4/YWHAB/SCRIB/CCND2/DLG4/GLI2/LIMD1/FZD8/FZD10/PARD6G/TEAD2/AJUBA/DLG3/TCF7L1	3.34683852901
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	58/2751	138/9376	1.43243827014156	PIP5K1C/BCAR1/PKN1/MAPK14/WASF2/SRC/AKT1/AKT3/CRK/ROCK2/ARPC1A/ARHGEF12/AKT2/MAP2K2/RPS6KA2/WASL/MAPK3/MAP2K1/CRKL/PIK3R2/MAPK1/RELA/MAP3K7/GNAQ/GIT2/IRAK1/DOCK1/WIPF2/CD4/TAB2/PIK3CA/LIMK1/TLR4/ARHGEF7/MAP2K7/ACTG1/PIK3R1/TRAF6/MAPK9/IKBKG/BAIAP2/RHOA/ARHGEF28/PLCG1/IL1B/MAPK12/RAC3/ELMO2/CHUK/MAPK11/VAV2/ELMO1/WIPF3/TAB1/MAPK10/IL6/IL10/RPS6KA6	3.2977116440849
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	113/2751	300/9376	1.28376105658548	PDGFRB/MAP3K5/TGFBR1/DAXX/KDR/PDGFRA/MAPK7/TGFBR2/TAOK1/MAPK14/IGF1R/INSR/AKT1/GNA12/AKT3/CRK/CSF1/DUSP3/IL1R1/FLNA/EGFR/GNG12/RASGRP2/MRAS/HRAS/VEGFA/AKT2/MAP2K2/RPS6KA2/FGF2/MAPK3/VEGFB/MAP2K1/MAP3K20/CRKL/TAOK2/GADD45G/ARAF/MAPK1/RELA/PRKACA/MAP3K7/MAP4K4/PRKACB/PPP3CB/IRAK1/ATF2/NF1/ELK4/MAP3K13/RAF1/SOS1/RRAS/RET/CSF1R/MAP3K4/STK3/TAB2/SRF/MAX/PRKCA/ARRB1/MAP2K7/NTRK1/PPP5C/TRAF6/CDC25B/CACNA2D1/MAPK9/IKBKG/PPP3CC/CACNA1G/DUSP7/FGF7/CD14/CACNA1C/HSPB1/IL1B/MAPK12/RAC3/CACNB3/PLA2G4D/RPS6KA4/RAP1B/MAP3K10/MAP2K5/MAP3K6/PDGFC/EFNA5/CACNA2D3/PTPN5/CHUK/IGF1/EPHA2/PLA2G4C/CACNA1H/MAPK11/EFNA4/FGF10/MAPT/ECSIT/CACNB1/MAPK8IP1/PDGFD/CACNB2/PLA2G4B/TAB1/MAPK10/DUSP1/MEF2C/EFNA3/KITLG/RPS6KA6	3.21887541909647
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	56/2751	133/9376	1.43503797662094	IRS1/SETD7/TGFBR1/BNIP3/TGFBR2/CSNK1E/G6PC3/MAPK14/IGF1R/INSR/AKT1/AKT3/DEPP1/EGFR/PRKAG1/IRS2/HRAS/AKT2/FOXO1/MAP2K2/CCNG2/MAPK3/MAP2K1/PIK3R2/GADD45G/ARAF/MAPK1/PRKAA1/CAT/USP7/RBL2/CDKN1B/STK11/HOMER3/RAF1/SOS1/PDPK1/PIK3CA/PIK3R1/FBXO25/MAPK9/FBXO32/CCND2/HOMER2/HOMER1/PRKAA2/PRKAB1/PRKAB2/MAPK12/CHUK/IGF1/PCK2/MAPK11/MAPK10/IL6/IL10	3.25600082593449
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	19/2751	34/9376	1.90459084397118	CSNK1E/FBXL3/PRKAG1/FBXW11/CSNK1D/NR1D1/CLOCK/RORB/RORA/PRKAA1/CUL1/BTRC/CREB1/CRY2/PRKAA2/PRKAB1/PRKAB2/NPAS2/PER3	3.40494190781701
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	39/2751	86/9376	1.54558596028506	ABL1/SRC/SHC1/AKT1/AKT3/CRK/CBLB/EGFR/BAD/HRAS/AKT2/MAP2K2/STAT5B/MAPK3/MAP2K1/CRKL/PIK3R2/NCK1/ARAF/MAPK1/CDKN1B/SHC3/RAF1/SOS1/RPS6KB1/PIK3CA/PRKCA/MTOR/CAMK2D/MAP2K7/PIK3R1/PAK3/MAPK9/PLCG2/PLCG1/SHC2/NRG2/MAPK10/CAMK2A	3.27523560604877
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	36/2751	78/9376	1.57302239744988	PIP5K1C/ITPK1/PI4K2A/PI4KA/PLCD1/CDIPT/PIP4K2B/MINPP1/ITPKC/INPP4B/PI4KB/PIK3C2A/INPPL1/TPI1/IP6K2/PIK3CA/PLCD3/OCRL/INPP5A/SACM1L/MTMR3/ALDH6A1/MTMR2/PLCG2/PLCE1/ITPKB/FIG4/INPP5K/IPPK/PLCG1/MTM1/INPP5B/ITPKA/INPP5E/PPIP5K1/IP6K3	3.27462912266837
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	63/2751	154/9376	1.39426985228512	AK4/DHRS3/NME4/NADK/AK2/VKORC1L1/VKORC1/CMPK1/COASY/RDH11/UROD/COQ4/NAPRT/UGDH/MOCS2/PDXP/AK6/SHMT2/PMM1/NME1/GMPPA/AK3/ADSL/MAT2B/PANK3/AKR1A1/AK1/ALAD/MPI/GMPPB/MTHFD1L/BCAT1/HAAO/FPGS/PNPO/PPOX/DLD/ALDH3A2/BCAT2/DHFR2/GSS/NADK2/UMPS/NQO1/ALDH1B1/COQ5/COX15/SPR/HSD17B6/DHODH/LIPT1/OXSM/LIAS/NFS1/MOCS1/NMNAT1/CMPK2/COX10/EARS2/AK9/CTPS2/GPHN/HMBS	3.17891828009342
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	63/2751	154/9376	1.39426985228512	ADCY1/MAPK7/NFATC4/SRC/ROCK2/GNAI1/EGFR/PRKAG1/PPP1R12C/CALM3/HRAS/MAP2K2/ADCY3/MAPK3/ADCY9/MAP2K1/NPR1/NPR2/MAPK1/PRKAA1/PRKACA/CAMKK2/GNAQ/PRKACB/PPP3CB/MYL6B/CAMK1/RAF1/PRKCA/CAMK2D/ACTG1/GNAO1/EEF2/MYL9/CACNA2D1/PPP3CC/RCAN1/RHOA/PRKAA2/CACNA1C/PRKAB1/EEF2K/PRKAB2/CACNB3/PLA2G4D/OXT/MAP2K5/GUCY1A2/ADCY2/CACNA2D3/PLA2G4C/ADCY6/CAMK1D/CACNB1/RYR1/MYLK3/GNAS/CACNB2/PLA2G4B/MEF2C/KCNJ5/CALM2/CAMK2A	3.17891828009342
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	104/2751	275/9376	1.28892501900136	LAMC1/UQCRC1/MAPK14/CREB3L2/PSMD3/NDUFS1/PSMD2/SDHA/KLC1/CSNK2B/NDUFV1/BAD/TUBA3D/PRNP/PSMC3/PSMD1/ADRM1/NDUFS3/NDUFB7/SDHC/MAPK3/COX7A1/NDUFS2/PIK3R2/NDUFS7/CYC1/PSMC2/NDUFA3/VDAC1/FYN/STIP1/NDUFA4L2/TUBB/PSMB7/ATP5F1B/ATP5F1A/MAPK1/PSMB4/ATF6B/NDUFS8/PRKACA/PSMC4/VDAC3/NDUFA6/PSMC5/PRKACB/PPP3CB/NDUFC1/CSNK2A2/TUBB6/NDUFS6/NDUFB3/ATF2/EIF2S1/CREB3L1/TUBA3E/NDUFB10/PSMC1/NDUFV3/KIF5B/UQCRC2/COX7A2L/NDUFS4/CREB3/ATP5PB/NDUFC2/SDHB/PIK3CA/NDUFA11/PSMB5/NDUFAB1/ATP5MC1/ATP5PO/C1QA/ATP5PD/PIK3R1/CREB1/NDUFB11/C1QB/MAPK9/NDUFB2/ATP5F1D/PSMD8/PPP3CC/UQCRQ/CACNA1C/IL1B/KLC2/NDUFA13/TUBB3/MAPK12/UQCR11/PSMA7/CASP9/MCU/MAPK11/KLC4/COX6B1/C1QC/KIF5A/RYR1/MAPK10/IL6/GRIN3B	3.13360991245287
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	8/2751	10/9376	2.72657215557979	PAPSS2/TST/SQOR/MPST/PAPSS1/ETHE1/SUOX/BPNT1	3.52002419101616
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	46/2751	106/9376	1.4790367825079	PDGFRB/PDGFRA/ZEB1/CREB3L2/IGF1R/AKT1/AKT3/EGFR/IL1R2/BAD/HRAS/AKT2/FOXO1/MAP2K2/MAPK3/MAP2K1/PIK3R2/ARAF/MAPK1/RELA/CDKN1B/CREB3L1/RAF1/SOS1/AR/CREB3/PDPK1/PLAT/PIK3CA/PLAU/MTOR/TCF7L2/FOLR2/PIK3R1/CREB1/IKBKG/ETV5/PDGFC/CHUK/IGF1/CASP9/SLC46A1/KLK3/PDGFD/HSP90B1/TCF7L1	3.19609676359721
Organismal Systems	Immune system	hsa04611	Platelet activation	53/2751	126/9376	1.43361432783461	ADCY1/GP1BB/MAPK14/SRC/AKT1/AKT3/ROCK2/GNAI1/ARHGEF12/RASGRP2/STIM1/AKT2/ADCY3/F2R/MAPK3/ADCY9/PIK3R2/FYN/TLN1/TLN2/MAPK1/PRKACA/GNAQ/PRKACB/ARHGAP35/PTGIR/PIK3CA/TBXA2R/ACTG1/PIK3R1/F2RL3/PRKCI/PLCG2/ITGB3/RHOA/MAPK12/COL3A1/PLA2G4D/RAP1B/GUCY1A2/ADCY2/COL1A2/PLA2G4C/ADCY6/MAPK11/FGG/MYLK3/GNAS/PLA2G4B/P2RY1/FGB/ADAMTS13/ITGA2B	3.15759206750858
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	43/2751	98/9376	1.49544136084096	PIP5K1C/PLPP3/WASF2/AKT1/AKT3/CRK/MYO10/ARPC1A/AKT2/MAPK3/MAP2K1/CRKL/PIK3R2/MAPK1/CFL2/PLD1/BIN1/INPPL1/SPHK1/GAB2/PLPP1/DOCK1/RAF1/RPS6KB1/PIK3CA/PRKCA/LIMK1/GSN/PRKCE/PIK3R1/ASAP2/SPHK2/AMPH/PLCG2/MARCKS/PLCG1/PLA2G4D/WASF1/PLA2G4C/VAV2/WASF3/FCGR2B/PLA2G4B	3.17699188665908
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	33/2751	71/9376	1.58410001996713	PRLR/MAPK14/SRC/SHC1/AKT1/ESR1/AKT3/SOCS5/HRAS/AKT2/MAP2K2/STAT5B/MAPK3/MAP2K1/PIK3R2/STAT1/MAPK1/RELA/SHC3/RAF1/SOS1/PIK3CA/PIK3R1/CISH/SOCS6/MAPK9/CCND2/GALT/MAPK12/PRL/MAPK11/SHC2/MAPK10	3.18343655414732
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	47/2751	110/9376	1.45623740127557	TGFBR1/NBL1/LRRC32/TGFBR2/INHBB/FMOD/PPP2R1A/LEFTY2/CHRD/PPP2CB/PPP2CA/BMPR2/SMAD2/SKI/TFRC/MAPK3/MAPK1/SMAD5/CUL1/SMAD9/NCOR1/THSD4/GDF7/BMP8A/DCN/PPP2R1B/RPS6KB1/BMPR1A/HDAC2/E2F4/ID4/SP1/NEO1/ACVR1B/FBN1/ZFYVE9/ACVR1/HFE/BMP4/RHOA/ACVR2A/ACVR1C/SMAD6/ACVR2B/EMP3/RGMB/RGMA	3.10155203374982
NA	NA	hsa04518	Integrin signaling	62/2751	154/9376	1.37213858478853	LAMB2/PDGFRB/ITGB8/TNXB/ITGB5/LAMC1/C3/KDR/ITGA1/LAMA4/PDGFRA/PARVA/COL6A3/IGF1R/SRC/AKT1/AKT3/ILK/FLNA/EGFR/VEGFA/AKT2/VEGFB/VTN/PIK3R2/COL4A4/LIMS2/TLN1/TLN2/VCL/COL6A1/ITGAV/PARVB/FERMT2/COL4A6/SPP1/ITGA3/COL4A5/LAMA2/COL6A2/PIK3CA/MTOR/LAMC3/THBS2/ACTG1/PIK3R1/LAMB1/COL4A3/FBN1/LIMS1/ITGB3/CCND2/ITGAE/RAC3/PDGFC/IGF1/COL1A2/LAMA1/FGG/PDGFD/FGB/ITGA2B	3.00047833496754
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	25/2751	51/9376	1.67069372278173	SEC61A1/ERO1A/ATP6V1E1/ATP6AP1/ATP6V0A1/ADCY3/ADCY9/PDIA4/PRKACA/PRKACB/ATP6V1A/ATP6V1D/PRKCA/ATP6V1C1/KDELR2/SEC61G/ACTG1/ARF1/PLCG2/PLCG1/ATP6V1G1/ATP6V0E2/GNAS/ATP6V0E1/ATP6V1G2	3.09473097355497
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	44/2751	103/9376	1.45593658793096	ADCY1/TGFBR1/C3/ACE/TGFBR2/PPP2R1A/MAPK14/AKT1/GNA11/AKT3/PPP2CB/PPP2CA/GNAI1/SMAD2/AKT2/MAPK3/PIK3R2/FADD/BDKRB2/MAPK1/RELA/GNAQ/IRAK1/PPP2R1B/PIK3CA/TLR4/C1QA/PIK3R1/GNAO1/TRAF6/C1QB/MAPK9/IKBKG/CCL3/IL1B/MAPK12/CHUK/MAPK11/C1QC/GNAS/MAPK10/IL6/GNA14/IL10	2.99813317050818
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	43/2751	101/9376	1.45102231051895	TGFBR1/TGFBR2/MAPK14/AKT1/AKT3/SMAD2/PLCD1/HRAS/VEGFA/AKT2/FOXO1/MMP2/STAT5B/MAPK3/VEGFB/PIK3R2/CDK4/STAT1/COL4A4/MAPK1/RELA/COL4A6/CDKN1B/COL4A5/F3/PIK3CA/PLCD3/PRKCA/PRKCE/PIK3R1/COL4A3/MAPK9/PLCG2/PLCE1/PLCG1/IL1B/MAPK12/COL3A1/COL1A2/MAPK11/MAPK10/IL6/NOX4	2.93656585895611
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	10/2751	15/9376	2.27214346298316	ST3GAL5/ST6GALNAC6/SLC33A1/HEXA/ST3GAL1/GLB1/B3GALT4/ST6GALNAC4/B4GALNT1/ST6GALNAC5	3.17730268388638
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	58/2751	144/9376	1.37275334221899	WNT4/WNT6/INHBB/MAPK14/IGF1R/TBX3/LEFTY2/AKT1/AKT3/BMI1/BMPR2/MEIS1/SMAD2/WNT5A/HRAS/WNT5B/AKT2/PCGF2/MAP2K2/FGF2/MAPK3/MAP2K1/PIK3R2/WNT9A/MAPK1/SMAD5/DVL1/PCGF5/SMAD9/DVL3/PCGF3/RAF1/APC/PIK3CA/BMPR1A/WNT3/FZD2/ID4/WNT10B/FZD1/SMARCAD1/PIK3R1/ACVR1B/FZD4/FZD3/ACVR1/WNT1/BMP4/PCGF1/MAPK12/ACVR2A/KLF4/FZD8/ACVR1C/IGF1/ACVR2B/MAPK11/FZD10	2.90464382982003
Organismal Systems	Nervous system	hsa04730	Long-term depression	28/2751	60/9376	1.59050042408821	PPP2R1A/IGF1R/GNA12/GNA11/PPP2CB/PPP2CA/GNAI1/HRAS/MAP2K2/MAPK3/MAP2K1/ARAF/MAPK1/GNAQ/RAF1/PPP2R1B/PRKCA/GNAO1/CRHR1/GRIA3/PLA2G4D/GUCY1A2/IGF1/PLA2G4C/GNAZ/RYR1/GNAS/PLA2G4B	2.95678053970168
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	40/2751	93/9376	1.46589900837623	TGFBR1/TGFBR2/IGF1R/WASF2/SRC/INSR/CTNND1/ROCK2/EGFR/CSNK2B/CCM2/WASL/MAPK3/CTNNA1/SORBS1/FYN/NECTIN2/PTPRM/MAPK1/VCL/MAP3K7/CSNK2A2/PTPN1/TCF7L2/HEG1/ACTG1/SNAI2/PARD3/MYL9/BAIAP2/NECTIN3/MYL5/FER/RHOA/NECTIN1/RAC3/RAP1B/WASF1/WASF3/TCF7L1	2.90955839032326
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	21/2751	42/9376	1.70410759723737	MAOB/AOX1/DLST/ACAT1/MAOA/CAT/CYP1B1/DHTKD1/ECHS1/HAAO/KYAT3/DLD/ALDH3A2/INMT/KYAT1/ALDH1B1/HADH/EHHADH/AADAT/GCDH/IL4I1	2.94691608557027
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	34/2751	77/9376	1.50492618976807	TGFBR1/TGFBR2/AKT1/AKT3/BCL2L1/EGFR/SMAD2/BAD/VEGFA/AKT2/MAPK3/MAP2K1/PIK3R2/CDK4/STAT1/RALB/GADD45G/ARAF/MAPK1/RELA/PLD1/POLK/RAF1/RPS6KB1/PIK3CA/MTOR/PIK3R1/BAK1/MAPK9/IKBKG/RAC3/CHUK/CASP9/MAPK10	2.86677183021725
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	56/2751	140/9376	1.36328607778989	ADCY1/TGFBR1/GNG4/NOTCH3/AKT1/AKT3/GNAI1/PRKAG1/MAP1LC3A/SMAD2/GNG12/CALM3/MRAS/HRAS/AKT2/GNB2/MAP2K2/ADCY3/GNB1/MAPK3/ADCY9/SLC9A1/MAP2K1/MEF2A/MAPK1/PRKAA1/PRKACA/GNB5/GNAQ/PRKACB/MEF2D/SPP1/SPHK1/HDAC4/RAF1/RRAS/RPS6KB1/PLAT/TFAM/MTOR/PRKCE/PLIN1/SPHK2/PRKAA2/PRKAB1/PRKAB2/PIK3R4/ADCY2/MEF2B/ADCY6/MYL3/RYR1/MYLK3/PPARGC1A/MEF2C/CALM2	2.7906720487285
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	36/2751	83/9376	1.47826201206133	PHC2/BMI1/CSNK2B/CBX7/PCGF2/CBX6/ASXL2/PCGF5/RING1/FOXK2/USP7/DCAF7/PCGF3/BAP1/MGA/PHC3/FBRS/MAX/HDAC2/FBRSL1/SFMBT2/HCFC1/PHF19/EZH1/E2F6/UBE2D4/L3MBTL2/PCGF1/FOXK1/SCMH1/WDR5/MBD5/USP45/PHC1/AUTS2/WDR5B	2.82010290747295
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	38/2751	89/9376	1.45519300438247	PDGFRB/ADCY1/GJA1/PDGFRA/LPAR1/MAPK7/SRC/GNA11/GNAI1/EGFR/HTR2B/TUBA3D/HRAS/MAP2K2/CSNK1D/ADCY3/MAPK3/ADCY9/MAP2K1/TUBB/MAPK1/PRKACA/GNAQ/PRKACB/TUBB6/TUBA3E/RAF1/SOS1/PRKCA/TUBB3/MAP2K5/GUCY1A2/PDGFC/ADCY2/HTR2A/ADCY6/GNAS/PDGFD	2.78029482688598
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	26/2751	56/9376	1.58238562600613	CSNK1E/PTCH1/FBXW11/GRK3/CSNK1D/MEGF8/BOC/CDON/SCUBE2/PRKACA/CUL1/PRKACB/MOSMO/GAS1/MGRN1/SUFU/ARRB1/BTRC/GPR161/CSNK1G1/KIF7/EVC/CCND2/DISP1/GLI2/SMO	2.81666175512418
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	16/2751	30/9376	1.81771477038653	MTR/ABCC1/ABCC3/ATIC/RELA/SHMT2/FOLR2/ABCC5/FPGS/IKBKG/DHFR2/ABCC4/IL1B/CHUK/SLC46A1/IL6	2.89059717292886
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	27/2751	59/9376	1.5596916991664	AKT1/AKT3/ILK/EGFR/BAD/HRAS/AKT2/MAP2K2/MAPK3/CTNNA1/MAP2K1/PIK3R2/GADD45G/ARAF/MAPK1/POLK/RAF1/SOS1/APC/PDPK1/PIK3CA/TCF7L2/PIK3R1/BAK1/MLH1/CASP9/TCF7L1	2.77891214014868
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	37/2751	87/9376	1.44947082983408	TGFBR1/TGFBR2/AKT1/AKT3/EGFR/SMAD2/BAD/HRAS/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/RALB/GADD45G/ARAF/MAPK1/APPL1/POLK/RAF1/SOS1/APC/MSH3/RPS6KB1/PIK3CA/MTOR/TCF7L2/PIK3R1/BAK1/MAPK9/MLH1/RHOA/RAC3/CASP9/MSH2/MAPK10/TCF7L1	2.71403003004115
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	13/2751	23/9376	1.92638250122485	B4GAT1/POMT2/B4GALT3/LARGE1/FKTN/POMGNT1/B4GALT2/RXYLT1/POMGNT2/CHST10/CRPPA/POMT1/FUT4	2.86626793895156
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	44/2751	107/9376	1.40150905193354	PFKL/G6PC3/GYS1/CREB3L2/AKT1/AKT3/SLC2A1/PRKAG1/CALM3/AKT2/FOXO1/PGAM1/PYGM/PFKP/PRKAA1/PRKACA/GNAQ/PRKACB/PPP3CB/ATF2/CREB3L1/PDHB/PPARA/PFKM/CPT1C/CREB3/SIK2/PKM/CAMK2D/CREB1/ACACB/PPP3CC/PYGB/LDHA/PRKAA2/PRKAB1/PRKAB2/ADCY2/PCK2/GNAS/PPARGC1A/PHKA2/CALM2/CAMK2A	2.69158922246473
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	29/2751	65/9376	1.52058831753488	KCNK3/ADCY1/PBX1/PDE8B/CREB3L2/GNA11/SCARB1/ADCY3/ADCY9/ATF6B/PRKACA/GNAQ/PDE8A/PRKACB/ATF2/LDLR/CREB3L1/CREB3/NCEH1/SP1/CREB1/CACNA1G/STAR/CACNA1C/KCNA4/ADCY2/CACNA1H/ADCY6/GNAS	2.71388177798154
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	39/2751	93/9376	1.42925153316682	ADCY1/MAPK7/MMP14/MAPK14/SRC/GNA11/EGFR/CALM3/HRAS/MAP2K2/MMP2/ADCY3/MAPK3/ADCY9/MAP2K1/MAPK1/PLD1/PRKACA/GNAQ/PRKACB/RAF1/SOS1/MAP3K4/PRKCA/CAMK2D/MAP2K7/MAPK9/CACNA1C/MAPK12/PLA2G4D/ADCY2/PLA2G4C/ADCY6/MAPK11/GNAS/PLA2G4B/MAPK10/CALM2/CAMK2A	2.68069340657643
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	61/2751	157/9376	1.32421099912713	MAP3K5/IRS1/UQCRC1/MAPK14/INSR/AKT1/NDUFS1/AKT3/SDHA/PRKAG1/IRS2/NDUFV1/AKT2/SREBF1/NDUFS3/NDUFB7/SDHC/COX7A1/NDUFS2/PIK3R2/NDUFS7/CYC1/NDUFA3/NDUFA4L2/RELA/PRKAA1/NDUFS8/NDUFA6/NDUFC1/NDUFS6/NDUFB3/EIF2S1/PPARA/NDUFB10/NDUFV3/UQCRC2/COX7A2L/NDUFS4/NDUFC2/SDHB/PIK3CA/NDUFA11/NDUFAB1/PIK3R1/NDUFB11/MAPK9/NDUFB2/CASP7/PRKAA2/UQCRQ/PRKAB1/IL1B/NDUFA13/LEPR/PRKAB2/MAPK12/UQCR11/MAPK11/COX6B1/MAPK10/IL6	2.6398159912734
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	51/2751	128/9376	1.35796074154853	ADCY1/PAPSS2/AK4/PDE8B/NME4/AK2/IMPDH2/ADCY3/NUDT16/ADCY9/NPR1/RRM1/NPR2/ATIC/NUDT9/PAICS/PDE8A/ENPP1/NTPCR/AK6/APRT/NME1/AK3/ADSL/PDE10A/HDDC2/NUDT5/ADA/GMPR2/AMPD3/AK1/IMPDH1/PAPSS1/HPRT1/PRPS2/ENTPD6/CANT1/PRUNE1/ENPP4/PPAT/GUCY1A2/ADCY2/PDE1A/PDE6D/GUK1/ADCY6/AK9/LACC1/ENTPD3/PFAS/PDE3A	2.62757103309885
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	84/2751	227/9376	1.26118976359418	ADCY1/PDGFRA/BCAR1/GNG4/MAPK14/NFATC4/CREB3L2/SRC/AKT1/GNA12/GNA11/AKT3/CRK/IL1R1/ROCK2/GNAI1/EGFR/CXCL12/ARHGEF12/GNG12/CALM3/HRAS/VEGFA/AKT2/GNB2/MAP2K2/ADCY3/GNB1/MAPK3/ADCY9/MAP2K1/CRKL/PIK3R2/CDK4/FADD/IL10RB/MAPK1/ATF6B/RELA/PRKACA/TAPBPL/GNB5/GNAQ/ITGAV/PRKACB/PPP3CB/ATF2/CREB3L1/RAF1/SOS1/RPS6KB1/CREB3/PIK3CA/PRKCA/MTOR/TSC2/SP1/PIK3R1/GNAO1/CREB1/BAK1/ARHGEF11/RHEB/IKBKG/CCL4/AKAP13/PPP3CC/CCL3/ITGB3/CCL4L2/RHOA/IL1B/MAPK12/RAC3/ADCY2/CHUK/CASP9/ADCY6/MAPK11/HLA-A/GNAS/CALM2/IL6/HLA-C	2.56696684408077
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	24/2751	52/9376	1.57302239744988	SOAT1/LRP1/SCARB1/OSBPL5/PLTP/VDAC1/VAPB/VDAC3/LDLR/LIPA/ABCA1/STARD3NL/APOA1/NCEH1/ANGPTL4/CYP27A1/NPC1/LRPAP1/STARD3/STAR/NPC2/SOAT2/LCAT/APOE	2.6699930373672
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	28/2751	63/9376	1.51476230865544	SETD7/PLOD1/COLGALT1/DLST/ASH1L/ACAT1/PLOD3/SETD2/KMT5B/DHTKD1/SETDB2/PLOD2/ECHS1/EZH1/AASS/DLD/SETD1A/ALDH3A2/TMLHE/PRDM6/ALDH1B1/HADH/EHHADH/NSD2/AADAT/GCDH/SETMAR/SUV39H1	2.6416191563055
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	28/2751	63/9376	1.51476230865544	WNT4/WNT6/PTCH1/WNT5A/WNT5B/WNT9A/GADD45G/DVL1/DVL3/POLK/APC/SUFU/WNT3/TCF7L2/FZD2/WNT10B/FZD1/BAK1/FZD4/FZD3/KIF7/WNT1/BMP4/GLI2/SMO/FZD8/FZD10/TCF7L1	2.6416191563055
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	54/2751	138/9376	1.3336494239249	UQCRC1/ATP6V1E1/NDUFS1/SDHA/ATP6AP1/NDUFV1/ATP6V0A1/NDUFS3/NDUFB7/SDHC/COX7A1/NDUFS2/NDUFS7/CYC1/NDUFA3/NDUFA4L2/ATP5F1B/ATP5F1A/NDUFS8/NDUFA6/NDUFC1/NDUFS6/ATP6V1A/ATP6V1D/NDUFB3/NDUFB10/NDUFV3/LHPP/UQCRC2/COX7A2L/NDUFS4/ATP5PB/NDUFC2/SDHB/NDUFA11/NDUFAB1/ATP5MC1/ATP5MF/ATP5PO/ATP6V1C1/ATP5PD/NDUFB11/NDUFB2/ATP5F1D/UQCRQ/ATP6V1G1/NDUFA13/ATP6V0E2/COX15/UQCR11/COX10/COX6B1/ATP6V0E1/ATP6V1G2	2.54436220448107
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	56/2751	144/9376	1.32541702007351	MAP3K5/ATP2A2/PSMD3/ULK1/AKT1/AKT3/PSMD2/AKT2/PSMC3/PSMD1/ADRM1/PIK3R2/VLDLR/RBPJ/PSMC2/VDAC1/PUM2/ATG13/RORA/PSMB7/PSMB4/ATXN10/PSMC4/VDAC3/GNAQ/PSMC5/WIPI2/RB1CC1/WIPI1/PSMC1/CIC/ATXN1/KAT5/OPA1/PIK3CA/PSMB5/PRKCA/MTOR/ATG101/ULK2/ATG2B/SP1/PIK3R1/ATXN3/MAPK9/GRIA3/PSMD8/ATXN1L/KCND3/PSMA7/PIK3R4/MCU/AMBRA1/RYR1/MAPK10/GRIN3B	2.53578018602882
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	30/2751	69/9376	1.48183269324989	MAPK14/AKT1/AKT3/HRAS/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/FYN/MAPK1/GAB2/RAF1/SOS1/PDPK1/PIK3CA/PRKCA/MAP2K7/PIK3R1/MAPK9/PLCG2/PLCG1/MAPK12/RAC3/PLA2G4D/PLA2G4C/MAPK11/VAV2/PLA2G4B/MAPK10	2.58853442384215
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	87/2751	238/9376	1.24586017613152	PDGFRB/KDR/ABL1/PDGFRA/PTPN11/GNG4/IGF1R/SHC1/INSR/AKT1/AKT3/RAB5B/BCL2L1/CSF1/EGFR/RASA3/GNG12/CALM3/RASGRP2/BAD/MRAS/HRAS/VEGFA/AKT2/RIN1/KSR1/GNB2/MAP2K2/FGF2/GNB1/RGL1/MAPK3/VEGFB/MAP2K1/PIK3R2/RALB/RAB5C/MAPK1/RELA/PLD1/PRKACA/GNB5/PRKACB/GAB2/NF1/SHC3/PLA2G12A/RAF1/SOS1/RRAS/CSF1R/PIK3CA/PRKCA/RALGAPB/NTRK1/PIK3R1/SYNGAP1/RASSF1/PAK3/MAPK9/IKBKG/PLCG2/PLCE1/RHOA/PLCG1/FGF7/RAC3/BRAP/PLA2G4D/RAP1B/EXOC2/PDGFC/EFNA5/CHUK/IGF1/EPHA2/PLA2G4C/SHC2/EFNA4/PLA2G2A/FGF10/PDGFD/PLA2G4B/MAPK10/EFNA3/CALM2/KITLG	2.47564906933345
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	33/2751	78/9376	1.44193719766239	CLTC/BCAR1/WASF2/SRC/SHC1/CRK/ILK/SEPTIN2/ARPC1A/SEPTIN9/WASL/CTNNA1/CRKL/PIK3R2/CTTN/VCL/SEPTIN11/DOCK1/SHC3/PIK3CA/SEPTIN8/ACTG1/PIK3R1/CLTCL1/CLTA/RHOA/MAD2L2/ELMO2/CLTB/WASF1/SHC2/ELMO1/DNM1	2.52552155778918
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	57/2751	148/9376	1.31262341949365	PGR/WNT4/WNT6/NOTCH3/IGF1R/SHC1/AKT1/ESR1/AKT3/DLL1/EGFR/WNT5A/HRAS/WNT5B/AKT2/MAP2K2/FGF2/MAPK3/MAP2K1/PIK3R2/CDK4/WNT9A/GADD45G/ARAF/MAPK1/DVL1/NCOA1/DVL3/SHC3/POLK/RAF1/SOS1/APC/RPS6KB1/PIK3CA/MTOR/WNT3/TCF7L2/FZD2/WNT10B/FZD1/SP1/PIK3R1/BAK1/LRP6/FZD4/FZD3/WNT1/FGF7/FZD8/LRP5/IGF1/HEYL/SHC2/FGF10/FZD10/TCF7L1	2.47022530306162
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	44/2751	110/9376	1.36328607778989	ADCY1/PGR/MAPK14/IGF1R/AKT1/AKT3/GNAI1/CDC27/AKT2/RPS6KA2/ADCY3/MAPK3/ADCY9/MAP2K1/PIK3R2/ARAF/MAD1L1/MAPK1/PRKACA/PRKACB/RAF1/CDC16/PIK3CA/KIF22/CPEB4/ANAPC7/ANAPC11/FZR1/PIK3R1/CDC25B/MAPK9/ANAPC10/CPEB1/ANAPC2/MAD2L2/MAPK12/CDC23/ANAPC4/ADCY2/IGF1/ADCY6/MAPK11/MAPK10/RPS6KA6	2.46965871331904
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	10/2751	17/9376	2.00483246733808	PAPSS2/MTR/TXNRD1/PAPSS1/SEPHS1/KYAT3/TXNRD2/INMT/KYAT1/TXNRD3	2.67203035991359
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	30/2751	70/9376	1.46066365477489	IRS1/PTPN11/G6PC3/AKT1/AKT3/SLC2A1/PRKAG1/IRS2/AKT2/RELA/PRKAA1/CAMKK2/APPL1/STK11/PPARA/CPT1C/TNFRSF1B/MTOR/RXRB/MAPK9/IKBKG/ACACB/PRKAA2/PRKAB1/LEPR/PRKAB2/CHUK/PCK2/PPARGC1A/MAPK10	2.4928114846631
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	31/2751	73/9376	1.44732426066735	AKT1/AKT3/EGFR/BAD/HRAS/AKT2/MAP2K2/STAT5B/MAPK3/MAP2K1/PIK3R2/CDK4/GADD45G/ARAF/MAPK1/POLK/RAF1/SOS1/KIF5B/RET/PDPK1/PIK3CA/PRKCA/PIK3R1/RXRB/BAK1/RASSF1/PLCG2/PLCG1/CASP9/KIF5A	2.47235234828549
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	17/2751	35/9376	1.65541880874487	PFKL/HK1/ALDOC/PFKP/PMM1/GMPPA/PFKM/HSD17B14/TPI1/HK2/ALDOA/MPI/GMPPB/PFKFB4/TKFC/FPGT/FCSK	2.50319238246455
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	29/2751	68/9376	1.45350353882011	AKT1/AKT3/BAD/HRAS/AKT2/MAP2K2/STAT5B/MAPK3/MAP2K1/PIK3R2/ARAF/MAPK1/RELA/ZBTB16/PML/RAF1/SOS1/CSF1R/RPS6KB1/PIK3CA/MTOR/TCF7L2/RUNX1T1/PIK3R1/IKBKG/PPARD/CD14/CHUK/TCF7L1	2.41849359447821
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	55/2751	144/9376	1.30174885900077	MAP3K5/C3/FASN/MAPK14/C2/ACADVL/AKT1/AKT3/PRKAG1/AKT2/SREBF1/FOXO1/FADD/SCD5/RELA/PRKAA1/MAP3K7/CAMKK2/LPIN1/IRAK1/SCD/PPARA/ADH5/CPT1C/IL17RC/TAB2/TLR4/TCF7L2/C1QA/MAP2K7/TRAF6/C1QB/MAPK9/IKBKG/ALDH3A2/ACACB/ACADM/PRKAA2/CD14/PRKAB1/ALDH1B1/IL1B/PRKAB2/MAPK12/CHUK/C3AR1/MAPK11/CXCL1/C1QC/PPARGC1A/TAB1/MAPK10/IL6/NOX4/TCF7L1	2.35134836413322
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	62/2751	166/9376	1.27294784371948	ADRA2C/ADCY1/IRS1/ATP2B4/EDNRB/NFATC4/CREB3L2/ATP2A2/INSR/AKT1/GNA12/GNA11/AKT3/ROCK2/GNAI1/IRS2/CALM3/BAD/AKT2/MAP2K2/GTF2I/ADCY3/MAPK3/ADCY9/MAP2K1/NPR1/MEF2A/VDAC1/BDKRB2/NPR2/MAPK1/ATF6B/VDAC3/GNAQ/PPP3CB/MEF2D/ATF2/CREB3L1/RAF1/CREB3/EDNRA/SRF/PRKCE/TRPC6/CREB1/MYL9/PPP3CC/RHOA/CACNA1C/GUCY1A2/ADCY2/MEF2B/ADCY6/KCNMB4/MYLK3/MEF2C/ADRA2A/ATP2B3/KCNMA1/CALM2/PDE3A/KCNJ8	2.28634565547547
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	16/2751	33/9376	1.65246797307866	VAMP2/VAMP3/YKT6/SNAP29/GOSR2/BET1L/VTI1B/STX7/VAMP4/GOSR1/STX8/STX17/STX2/BET1/STX1B/BNIP1	2.41941844038206
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	24/2751	55/9376	1.48722117577079	PLPP3/CERS6/SPTLC2/SMPD1/CERK/SGPL1/ACER3/KDSR/HEXA/SPTLC1/GALC/CERS2/DEGS1/ARSA/SGPP1/SMPD4/SPHK1/GLB1/PLPP1/SPHK2/CERS4/PSAP/GBA2/B4GALNT1	2.33514707137008
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	39/2751	98/9376	1.35633053657668	PIP5K1C/ITPK1/PI4K2A/PI4KA/PLCD1/CALM3/CDIPT/PIP4K2B/ITPKC/PIK3R2/INPP4B/PI4KB/PIK3C2A/INPPL1/IP6K2/PIP4P2/PIK3CA/PLCD3/PRKCA/OCRL/PIK3R1/INPP5A/SACM1L/MTMR3/MTMR2/PLCG2/PLCE1/ITPKB/IPPK/PLCG1/DGKH/DGKQ/MTM1/INPP5B/ITPKA/INPP5E/PPIP5K1/IP6K3/CALM2	2.28495098138647
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	90/2751	253/9376	1.21240856720445	C3/BCAR1/HK1/BNIP3/MAPK14/WASF2/SRC/AKT1/CAPNS1/AKT3/CRK/ILK/BCL2L1/IL1R1/ROCK2/SEPTIN2/EGFR/ARPC1A/MAP1LC3A/PLCD1/FBXW11/UBE2V2/AKT2/FOXO1/SEPTIN9/CAPN1/WASL/MAPK3/CRKL/SHARPIN/PIK3R2/CTTN/VDAC1/TLN1/TLN2/MAPK1/TNIP1/RELA/RRAGA/CUL1/VCL/MAP3K7/SEPTIN11/PFN2/WIPI2/AKT1S1/UBE2V1/WIPI1/DOCK1/PPID/HK2/RPS6KB1/TAB2/RPTOR/PIK3CA/PLCD3/MTOR/TLR4/SEPTIN8/PRKCE/RNF31/ACTG1/BTRC/PIK3R1/TRAF6/MYL9/MAPK9/IKBKG/UBE2D4/ARF1/ATG16L1/RRAGD/PLCG2/PLCE1/CYTH3/MYL5/RHOA/PLCG1/CD14/IL1B/MAPK12/ELMO2/PIK3R4/CHUK/WASF1/MAPK11/ELMO1/TAB1/MAPK10/NOD1	2.20699548488107
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	32/2751	78/9376	1.39824213106656	SERPING1/C3/MAPK14/C2/C1R/GNAI1/C1S/CALM3/MAPK3/MAPK1/CFL2/RELA/IRAK1/TICAM2/TLR4/C1QA/TRAF6/C1QB/MAPK9/CASP7/RHOA/CD14/IL1B/MAPK12/MAPK11/C1QC/C4BPB/MAPK10/CALM2/IL6/IL10/NOD1	2.27581903616278
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	21/2751	47/9376	1.52281955497807	PC/HAGH/GLO1/ACAT1/GRHPR/PDHB/ADH5/AKR1A1/PKM/MDH1/ACYP2/ME1/DLD/ALDH3A2/ACACB/LDHA/DLAT/ALDH1B1/ACSS2/PCK2/ME3	2.31537424230703
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	15/2751	31/9376	1.64913638442326	H6PD/GPI/PFKL/ALDOC/PGD/PFKP/G6PD/PGLS/PFKM/ALDOA/PRPS2/RPE/SHPK/RBKS/IDNK	2.33273356526261
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	28/2751	67/9376	1.42432873798944	ENO2/GPI/PFKL/HK1/ALDOC/G6PC3/ALDH3B1/PGAM1/MINPP1/PFKP/PDHB/PFKM/ADH5/AKR1A1/TPI1/HK2/ALDOA/ENO1/PKM/PGK1/DLD/ALDH3A2/LDHA/DLAT/ALDH1B1/ACSS2/PCK2/GAPDH	2.24608570576652
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	39/2751	99/9376	1.34263022812641	ADCY1/MAPK14/SRC/IL1R1/CALM3/HTR2B/ADCY3/ADCY9/PIK3R2/BDKRB2/PRKACA/GNAQ/PRKACB/PIK3CA/PRKCA/CAMK2D/PRKCE/NTRK1/PIK3R1/MAPK9/PLCG2/PLCG1/IL1B/MAPK12/PLA2G4D/BDKRB1/ADCY2/ASIC3/IGF1/PLA2G4C/HTR2A/ADCY6/MAPK11/GNAS/PLA2G4B/MAPK10/ASIC1/CALM2/CAMK2A	2.20839871874268
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	42/2751	108/9376	1.32541702007351	RANGAP1/IPO5/KPNA6/KPNB1/TNPO1/NCBP2/SUMO3/UPF1/XPO1/IPO9/PHAX/UPF2/XPO7/CSE1L/KPNA1/THOC2/CASC3/NUP50/TNPO3/TNPO2/IPO13/XPO5/KPNA3/IPO8/NUP54/MAGOHB/AAAS/NUP188/SENP2/NUP43/XPO4/NUP85/SNUPN/DDX19B/IPO4/NDC1/IPO11/NUP133/GLE1/KPNA5/NUP205/NXT2	2.19178081462208
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	16/2751	34/9376	1.60386597387046	POLR2E/POLR2K/POLR1E/POLR2B/POLR2I/POLR2M/POLR3H/POLR1A/POLR3GL/POLR3B/POLR1B/POLR3D/POLR3A/POLR1C/POLR2L/POLR3F	2.27299289489801
NA	NA	hsa04517	IgSF CAM signaling	104/2751	299/9376	1.18546615459991	CLMP/NLGN2/PLXNA4/KDR/ABL1/BCAR1/PTPN11/PPFIA1/MAPK14/SRC/LRFN4/NFASC/AKT1/NRP1/SPTAN1/SPTBN1/AKT3/ARPC1A/MPDZ/NLGN4X/TUBA3D/AKT2/FOXO1/MAP2K2/WASL/MAPK3/MAP2K1/PIK3R2/NCK1/SORBS1/FYN/NECTIN2/TUBB/MAPK1/JAM3/EPB41L2/MSN/VCL/EPB41L1/MTSS2/TUBB6/MYL6B/TUBA3E/APP/SLIT3/ERC1/PMP22/NRCAM/PDPK1/PIK3CA/MYH9/PRKCA/PLXNA1/CNTNAP1/DOK1/PLXNA3/ACTG1/TRPC6/PIK3R1/TRAF6/PARD3/CSK/PAK3/MYL9/PRKCI/KIRREL1/MAPK9/BAIAP2/NECTIN3/PLCG2/MAGI2/ITGB3/NLGN1/UNC5B/RHOA/NECTIN1/PLCG1/KCNQ3/TUBB3/MAPK12/RAP1B/CD209/KCNA4/SPTBN4/CDH2/NTN1/CASKIN2/MAPK11/VAV2/MAGI1/MTSS1/UNC5C/PPFIA4/FGG/MYLK3/PARD6G/MAPK10/CD28/PTPRD/FGB/KIRREL3/PPFIA3/L1CAM/CADM4	2.10023110425125
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	34/2751	85/9376	1.36328607778989	AK4/DCTD/NME4/AK2/IMPDH2/NUDT16/CMPK1/RRM1/TK2/ENPP1/NTPCR/AK6/APRT/NME1/AK3/ADSL/HDDC2/ADA/GMPR2/AMPD3/AK1/IMPDH1/DUT/HPRT1/ENTPD6/CANT1/NT5C3B/DTYMK/GUK1/CMPK2/AK9/LACC1/CTPS2/ENTPD3	2.16802846339709
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	35/2751	88/9376	1.35554013416609	SERPING1/C3/C2/F10/C1R/CFH/C1S/F2R/VTN/F13A1/BDKRB2/PROS1/A2M/F3/PLAT/MASP1/CD59/PLAU/F12/CFI/C1QA/VSIG4/F2RL3/C1QB/TFPI/CLU/F8/BDKRB1/C3AR1/C1QC/C4BPB/FGG/SERPINF2/CFD/FGB	2.15926953201029
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	26/2751	62/9376	1.42925153316682	NCOR2/TLE2/NOTCH3/NCSTN/DLL1/NUMBL/APH1B/CTBP2/RBPJ/DTX1/DVL1/PSENEN/LFNG/TLE6/DVL3/RFNG/APH1A/ATXN1/MAML2/HDAC2/PSEN2/KAT2A/ATXN1L/DTX3/MAML3/HEYL	2.18513148672721
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	72/2751	200/9376	1.2269574700109	ABL1/LPAR1/MYO1C/PTPN11/NCKAP1/MAPK14/WASF2/SRC/GNA12/IL1R1/ROCK2/MYO10/ARPC1A/ARHGEF12/TUBA3D/MYO1B/WASL/F2R/MAPK3/ABI1/NCK1/CTTN/FADD/FYN/TUBB/MAPK1/RELA/MYO5A/RAB1A/MAP3K7/SEC24C/IRAK1/TUBB6/TUBA3E/SEC24B/WIPF2/CYFIP1/TAB2/BRK1/MYH9/TLR4/TMED10/ACTG1/BAK1/TRAF6/ARHGEF11/ABCF2/PAK3/MAPK9/IKBKG/ARF1/BAIAP2/CASP7/CLDN12/CYTH3/RHOA/TMBIM6/IL1B/TUBB3/MAPK12/MYO1D/CHUK/CASP9/WASF1/MAPK11/WASF3/GAPDH/WIPF3/TAB1/MAPK10/TNFRSF10A/IL6	2.09059914781509
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	40/2751	103/9376	1.32357871630087	LAMB2/ADCY1/LAMC1/LAMA4/GNA11/RAB5B/IL1R1/IL1R2/PIK3R2/COL4A4/RAB5C/RELA/PRKACA/VCL/GNAQ/PRKACB/COL4A6/COL4A5/LAMA2/PIK3CA/PRKCA/TLR4/LAMC3/RAB7A/PIK3R1/LAMB1/COL4A3/RAB7B/ARG1/CD14/HSPB1/IL1B/COL3A1/COL1A2/CXCL1/LAMA1/GNAS/IL6/GNA14/IL10	2.12777852949806
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	52/2751	139/9376	1.27501575620638	ADCY1/GREB1/PGR/CREB3L2/SRC/SHC1/AKT1/ESR1/AKT3/GNAI1/EGFR/CALM3/HRAS/AKT2/MAP2K2/MMP2/ADCY3/MAPK3/ADCY9/MAP2K1/PIK3R2/MAPK1/ATF6B/PRKACA/NCOA1/GNAQ/PRKACB/ATF2/CREB3L1/FKBP5/SHC3/RAF1/SOS1/EBAG9/CREB3/PIK3CA/KRT34/KRT23/SP1/PIK3R1/GNAO1/CREB1/CTSD/ADCY2/ADCY6/SHC2/GABBR1/GNAS/KCNJ5/CALM2/HSP90B1/KRT37	2.10492921830874
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	50/2751	133/9376	1.28128390769727	GNG4/MAOB/PPP2R1A/MAPK14/CREB3L2/AKT1/AKT3/PPP2CB/PPP2CA/GNAI1/GNG12/CALM3/AKT2/PPP2R5E/GNB2/GNB1/CLOCK/MAOA/ATF6B/PRKACA/GNB5/GNAQ/PRKACB/PPP3CB/ATF2/CREB3L1/PPP2R1B/KIF5B/CREB3/PRKCA/CAMK2D/PPP2R5B/COMT/ARRB1/PPP2R3A/GNAO1/CREB1/PPP2R5D/MAPK9/GRIA3/PPP3CC/CACNA1C/MAPK12/MAPK11/KIF5A/GNAS/MAPK10/KCNJ5/CALM2/CAMK2A	2.10524295579464
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	55/2751	149/9376	1.25806601138329	ADCY1/CNR1/GNG4/MAPK14/NDUFS1/GNAI1/NDUFV1/GNG12/GNB2/NDUFS3/NDUFB7/ADCY3/GNB1/MAPK3/ADCY9/NDUFS2/NDUFS7/NDUFA3/NDUFA4L2/MAPK1/NDUFS8/PRKACA/GNB5/GNAQ/NDUFA6/PRKACB/NDUFC1/NDUFS6/NDUFB3/NDUFB10/NDUFV3/MGLL/NDUFS4/NDUFC2/NDUFA11/NDUFAB1/PRKCA/DAGLB/GNAO1/NDUFB11/MAPK9/NDUFB2/GRIA3/ABHD6/GABRB3/CACNA1C/NDUFA13/MAPK12/ADCY2/ADCY6/MAPK11/MAPK10/KCNJ5/NAPEPLD/GABRA3	2.04612270924897
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	50/2751	134/9376	1.27172208749057	ADCY1/GNA12/GNA11/ROCK2/PPP1R12C/ARHGEF12/CALM3/MAP2K2/ADCY3/MAPK3/ADCY9/MAP2K1/NPR1/NPR2/ARAF/MAPK1/PRKACA/GNAQ/PRKACB/RAMP3/MYL6B/PLA2G12A/PTGIR/RAF1/EDNRA/MYH9/PRKCA/ADORA2B/PRKCE/CALD1/ARHGEF11/MYL9/RAMP1/RHOA/CACNA1C/PLA2G4D/AVPR1A/GUCY1A2/ADCY2/ADM/PLA2G4C/ADCY6/PLA2G2A/PPP1R14A/KCNMB4/MYLK3/GNAS/PLA2G4B/KCNMA1/CALM2	2.04141993548107
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	10/2751	19/9376	1.79379747077618	DLST/BCKDHA/PDHB/DHTKD1/DBT/DLD/DLAT/LIPT1/LIAS/BCKDHB	2.23180470412365
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	46/2751	122/9376	1.28506474545769	PTPN11/PPP2R1A/MAPK14/AKT1/AKT3/PPP2CB/CBLB/PPP2CA/HRAS/AKT2/PPP2R5E/MAP2K2/MAPK3/MAP2K1/PIK3R2/NCK1/CDK4/FYN/MAPK1/RELA/MAP3K7/PPP3CB/RAF1/PPP2R1B/SOS1/CD4/PDPK1/PIK3CA/PPP2R5B/PPP2R3A/MAP2K7/PIK3R1/PPP2R5D/PAK3/MAPK9/IKBKG/PPP3CC/RHOA/PLCG1/MAPK12/CHUK/MAPK11/VAV2/MAPK10/CD28/IL10	2.04219246935742
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	13/2751	27/9376	1.64099250104339	FADS1/FADS2/HSD17B4/HSD17B12/HACD3/ELOVL1/SCD5/SCD/ELOVL3/ELOVL6/ELOVL4/ACOT4/ACOT2	2.14926636889715
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	30/2751	75/9376	1.36328607778989	MAP3K5/AKT1/AKT3/BCL2L1/XIAP/BAD/AKT2/MAPK3/PIK3R2/FADD/MAPK1/MGST2/GSTT2B/ERCC1/MSH3/GSTM3/PDPK1/PIK3CA/PIK3R1/BAK1/REV3L/ATP7A/GSTA4/MLH1/MGST1/GSTM5/CASP9/GSTM4/MSH2/POLH	2.03541305776618
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	36/2751	93/9376	1.31930910753861	LAMB2/LAMC1/LAMA4/AKT1/AKT3/BCL2L1/XIAP/AKT2/PIK3R2/CDK4/COL4A4/GADD45G/RELA/ITGAV/COL4A6/CDKN1B/ITGA3/COL4A5/LAMA2/POLK/PIK3CA/MAX/LAMC3/PIK3R1/RXRB/BAK1/TRAF6/LAMB1/COL4A3/IKBKG/ZBTB17/CHUK/CASP9/LAMA1/BIRC7/ITGA2B	1.99409845533594
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	28/2751	70/9376	1.36328607778989	EGLN2/EGLN1/PTPN11/AKT1/AKT3/CRK/SLC2A1/BAD/HRAS/VEGFA/AKT2/MAP2K2/MAPK3/MAP2K1/CRKL/PIK3R2/ARAF/MAPK1/TFE3/RAF1/SOS1/PIK3CA/ARNT/PIK3R1/CUL2/PAK3/RAP1B/ELOB	1.9658674990876
Human Diseases	Cancer: specific types	hsa05218	Melanoma	29/2751	73/9376	1.35394850191462	PDGFRB/PDGFRA/IGF1R/AKT1/AKT3/EGFR/BAD/HRAS/AKT2/MAP2K2/MITF/FGF2/MAPK3/MAP2K1/PIK3R2/CDK4/GADD45G/ARAF/MAPK1/POLK/RAF1/PIK3CA/PIK3R1/BAK1/FGF7/PDGFC/IGF1/FGF10/PDGFD	1.95626637503457
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	122/2751	362/9376	1.14862501029259	LAMB2/PDGFRB/PRLR/ITGB8/TNXB/IRS1/ITGB5/LAMC1/KDR/ITGA1/LAMA4/PDGFRA/LPAR1/PKN1/GNG4/COL6A3/PPP2R1A/G6PC3/OSMR/GYS1/CREB3L2/IGF1R/INSR/AKT1/AKT3/PPP2CB/BCL2L1/PPP2CA/IFNAR1/CSF1/EGFR/GNG12/BAD/HRAS/VEGFA/AKT2/PPP2R5E/GNB2/MAP2K2/FGF2/GNB1/F2R/MAPK3/VEGFB/MAP2K1/VTN/PIK3R2/CDK4/COL4A4/MAPK1/ATF6B/RELA/PRKAA1/GNB5/COL6A1/ITGAV/COL4A6/SPP1/RBL2/CDKN1B/EPOR/ATF2/STK11/CREB3L1/ITGA3/COL4A5/LAMA2/COL6A2/RAF1/PPP2R1B/SOS1/RET/CSF1R/RPS6KB1/RPTOR/CREB3/PDPK1/PIK3CA/PRKCA/MLST8/MTOR/TLR4/LAMC3/PPP2R5B/THBS2/TSC2/PPP2R3A/NTRK1/PIK3R1/CREB1/LAMB1/PPP2R5D/COL4A3/RHEB/IKBKG/MAGI2/ITGB3/YWHAB/GHR/CCND2/PRKAA2/FGF7/PRL/PDGFC/EFNA5/CHUK/IGF1/COL1A2/CASP9/EPHA2/PCK2/EFNA4/MAGI1/FGF10/LAMA1/PDGFD/CSF3/EFNA3/IL6/KITLG/ITGA2B/HSP90B1	1.85834095501469
NA	NA	hsa04519	Cadherin signaling	135/2751	404/9376	1.13888379023289	PDGFRB/GJA1/CDH11/KDR/WNT4/PDGFRA/ATN1/WNT6/MYO1C/NCKAP1/TAOK1/MAPK14/IGF1R/NCSTN/YAP1/CTNND1/PRICKLE2/ROCK2/EGFR/LATS2/ARPC1A/AMOTL2/WNT5A/MPDZ/MRAS/HRAS/WNT5B/MAP2K2/MYO1B/LHFPL2/PCDH20/APH1B/MAPK3/CTNNA1/WWTR1/MAP2K1/ADAM10/TAOK2/WNT9A/DAAM1/MAPK1/RELA/DVL1/LHFPL6/VCL/PSENEN/ERBIN/RERE/MOB1A/NF2/SCN1B/DVL3/ARHGAP35/APH1A/CYFIP1/RAF1/TEAD3/RRAS/APC/SAV1/LATS1/STK3/BRK1/KRT34/WNT3/TCF7L2/FZD2/PCDHB16/WNT10B/FZD1/WTIP/KRT23/ACTG1/PSEN2/LRP6/VANGL1/MAPK9/FZD4/FZD3/IKBKG/TMC1/WNT1/LIMA1/YWHAB/PCDHB10/RHOA/GABRB3/MAPK12/RAC3/LIMD1/PCDH19/FZD8/PCDH18/PCDHB2/LRP5/PCDHB14/MYO1D/CDH2/FAT4/CHUK/PCDHB4/PCDHGA10/WASF1/MAPK11/VAV2/PRICKLE3/DCHS1/FZD10/PCDH12/PCDHGA7/CELSR3/PCDHGA9/TMIE/PCDHB11/PCDHA10/PCDHB13/DCHS2/PCDHGA6/PCDHGB7/PCDHGA2/PCDH9/MAPK10/PCDHB7/TEAD2/PRICKLE1/PCDHGB6/AJUBA/CDH24/DAAM2/PCDHB9/GABRA3/PCDHGC3/CDH13/TCF7L1/KRT37	1.83880468829497
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	24/2751	59/9376	1.38639262148125	GGT5/ANPEP/SRM/PGD/RRM1/GPX8/TXNDC12/LAP3/G6PD/LANCL1/MGST2/GSTT2B/GSTM3/GPX7/IDH1/GSTA4/GSS/GGT7/MGST1/GSTM5/GSTM4/HPGDS/GPX4/OPLAH	1.91846895049068
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	50/2751	137/9376	1.24387415856742	MAP3K5/DAXX/PTPN13/CTSO/AKT1/SPTAN1/AKT3/BCL2L1/XIAP/DAB2IP/BAD/TUBA3D/HRAS/AKT2/MAP2K2/CAPN1/MAPK3/MAP2K1/PIK3R2/NOL3/FADD/GADD45G/CTSB/MAPK1/RELA/PARP4/DFFA/EIF2S1/TUBA3E/RAF1/PDPK1/CTSK/PIK3CA/PARP3/ACTG1/NTRK1/PIK3R1/BAK1/MAPK9/IKBKG/HTRA2/CASP7/AIFM1/CTSC/CTSD/CHUK/CASP9/CASP6/MAPK10/TNFRSF10A	1.85289827109743
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	28/2751	71/9376	1.34408486542666	PTPN11/MAPK14/ATP6V1E1/SRC/EGFR/ATP6AP1/ATP6V0A1/ADAM10/JAM3/RELA/ATP6V1A/ATP6V1D/ATP6V1C1/CSK/MAPK9/IKBKG/PLCG2/PLCG1/ATP6V1G1/ATP6V0E2/MAPK12/CHUK/MAPK11/CXCL1/ATP6V0E1/ATP6V1G2/MAPK10/NOD1	1.87531638569319
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	37/2751	98/9376	1.28677512444454	KCNK3/ADCY1/ATP2B4/CREB3L2/GNA11/SCARB1/CALM3/ADCY3/ADCY9/NPR1/ATF6B/PRKACA/GNAQ/PRKACB/CAMK1/ATF2/LDLR/CREB3L1/CREB3/PRKCA/CAMK2D/DAGLB/PRKCE/CREB1/CACNA1G/STAR/CACNA1C/ADCY2/CACNA1H/ADCY6/CAMK1D/GNAS/PRKD1/ATP2B3/KCNJ5/CALM2/CAMK2A	1.83893052875017
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	54/2751	150/9376	1.2269574700109	TGFBR1/WNT4/WNT6/TGFBR2/SHC1/AKT1/AKT3/EGFR/SMAD2/WNT5A/HRAS/WNT5B/AKT2/MAP2K2/FGF2/MAPK3/CTNNA1/MAP2K1/PIK3R2/WNT9A/GADD45G/ARAF/MAPK1/DVL1/CDKN1B/DVL3/SHC3/POLK/RAF1/SOS1/APC/RPS6KB1/PIK3CA/MTOR/WNT3/TCF7L2/FZD2/WNT10B/FZD1/PIK3R1/RXRB/BAK1/LRP6/FZD4/FZD3/MLH1/WNT1/FGF7/FZD8/LRP5/SHC2/FGF10/FZD10/TCF7L1	1.80559930139196
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	11/2751	23/9376	1.63001596257487	PCYOX1/ICMT/NUS1/ACAT1/ZMPSTE24/PMVK/GGPS1/MVD/RCE1/PDSS2/FNTB	1.94929691803167
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	22/2751	54/9376	1.38853211626749	MTR/AHCY/AHCYL1/SRM/CISD1/TST/MAT2B/GOT2/MDH1/MTAP/MPST/BCAT1/KYAT3/BHMT2/BCAT2/SDSL/GSS/LDHA/KYAT1/LACC1/AHCYL2/IL4I1	1.84504620406791
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/2751	37/9376	1.47382278679989	NCOA4/HRAS/MAP2K2/MAPK3/MAP2K1/GADD45G/TFG/MAPK1/CCDC6/POLK/RET/TCF7L2/NTRK1/RXRB/BAK1/TCF7L1	1.86082104527509
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	34/2751	90/9376	1.28754796235712	PTPN11/MAPK14/AKT1/AKT3/EGFR/CSNK2B/HRAS/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/STAT1/MAPK1/RELA/PPP3CB/CSNK2A2/RAF1/TICAM2/CD4/RPS6KB1/PIK3CA/MTOR/TLR4/PIK3R1/TRAF6/IKBKG/PPP3CC/PLCG1/MAPK12/CHUK/MAPK11/CD28/BATF2	1.76626230947081
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	9/2751	18/9376	1.70410759723737	FASN/ACACB/OLAH/MCAT/ACSF3/CBR4/OXSM/HSD17B8/MECR	1.92673397046204
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	9/2751	18/9376	1.70410759723737	HEXA/MAN2C1/MAN2B1/MAN2B2/FUCA2/GLB1/MANBA/GBA2/ENGASE	1.92673397046204
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	9/2751	18/9376	1.70410759723737	MTR/MMADHC/HCFC1/ABCD4/MMUT/ZNF76/MMAA/MTRR/TCN2	1.92673397046204
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	77/2751	224/9376	1.17157397310069	ADCY1/TGFBR1/TGFBR2/NFATC4/CREB3L2/AKT1/NRP1/IL15RA/AKT3/BCL2L1/XIAP/IL1R1/SLC2A1/CDC27/SMAD2/LTBR/IL1R2/HRAS/AKT2/GPS2/MAP2K2/ADCY3/STAT5B/MAPK3/ADCY9/MAP2K1/PIK3R2/CDK4/VDAC1/XPO1/TLN1/TLN2/MAD1L1/MAPK1/ATF6B/RELA/PRKACA/VDAC3/CHEK2/PRKACB/PPP3CB/ATF2/CRTC1/CREB3L1/ELK4/CDC16/CANX/CD4/IL15/KAT5/CREB3/PIK3CA/SRF/ANAPC7/ANAPC11/PIK3R1/RANBP3/CREB1/KAT2A/MAPK9/IKBKG/ATR/ANAPC10/PPP3CC/VAC14/CCND2/ANAPC2/CDC23/ANAPC4/ADCY2/CHUK/ADCY6/HLA-A/MAPK10/IL6/HLA-C/ZFP36	1.67477089067182
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	42/2751	115/9376	1.2447394623299	ADCY1/MMP14/CREB3L2/GNA12/GNA11/GNAI1/WNK1/EGFR/ADCY3/MAPK3/ADCY9/MAP2K1/MEF2A/ARAF/MAPK1/ATF6B/PLD1/PRKACA/GNAQ/PRKACB/MEF2D/ATF2/CREB3L1/RAF1/CREB3/PRKCA/ARRB1/SP1/RXRB/CREB1/ARHGEF11/LRP6/MMP17/AKAP13/RHOA/LRP5/ADCY2/ADCY6/WNK2/WNK3/GNAS/MEF2C	1.70161761133928
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	11/2751	24/9376	1.56209863080092	B3GAT3/EXT2/HS2ST1/NDST2/B3GALT6/B4GALT7/NDST1/EXTL1/XYLT2/EXT1/XYLT1	1.77665822699028
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	38/2751	104/9376	1.24530939798115	PLPP3/AGPAT1/PLD3/GPAT4/PISD/CDIPT/PEMT/AGPAT2/LPCAT2/CHPT1/PLD1/PCYT1A/LPIN1/PLPP1/PLA2G12A/MBOAT2/PTDSS2/GNPAT/PNPLA6/GPD1L/AGPAT3/GPD2/AGPAT5/PLA2G15/CEPT1/LCLAT1/PLA2G4D/DGKH/DGKQ/GDPD5/ETNK2/PLA2G4C/PLA2G2A/PNPLA7/GPAM/SELENOI/LCAT/PLA2G4B	1.62099672315831
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	21/2751	53/9376	1.35042488837678	ATP2B4/CLTC/AP2A1/AP2B1/ESR1/ADCY9/AP2M1/BDKRB2/AP2A2/RAB11A/PRKACA/GNAQ/PRKACB/PRKCA/CLTCL1/CLTA/CLTB/ADCY6/GNAS/ATP2B3/DNM1	1.64851547550271
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	23/2751	59/9376	1.32862626225286	ADCY1/IRS1/PNPLA2/INSR/AKT1/AKT3/GNAI1/IRS2/AKT2/ADCY3/ADCY9/PIK3R2/NPR1/PRKACA/PRKACB/MGLL/PIK3CA/PIK3R1/PLIN1/ADCY2/ADCY6/GNAS/CIDEC	1.63165455393801
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	25/2751	65/9376	1.3108519978749	AKT1/GNA11/AKT3/HRAS/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/MAPK1/GNAQ/SPP1/RAF1/TRPC1/PIK3CA/PRKCA/ARRB1/PIK3R1/TRPC4/CACNA1G/CACNA1C/CACNA1H/GABBR1/HCN2/KCNJ5	1.62050423389556
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	38/2751	105/9376	1.23344930847657	PTPN11/MAPK14/NFATC4/SRC/AKT1/AKT3/CBLB/ARHGEF12/CALM3/MRAS/HRAS/AKT2/KSR1/MAPK3/PIK3R2/STAT1/CARD9/MAPK1/RELA/PPP3CB/RAF1/RRAS/PIK3CA/PIK3R1/MAPK9/IKBKG/PLCG2/PPP3CC/RHOA/IL1B/MAPK12/CD209/CHUK/MAPK11/MAPK10/CALM2/IL6/IL10	1.55010794736791
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	18/2751	45/9376	1.36328607778989	ABCB8/ABCC1/ABCC3/ABCA8/ABCA1/ABCD3/ABCA3/ABCD1/ABCC5/ABCA2/ABCD4/ABCB6/ABCC10/ABCC4/ABCB10/ABCB7/ABCA6/ABCC9	1.57408764073386
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	29/2751	78/9376	1.26715693127907	ENO2/PFKL/CNOT8/DDX6/EXOSC4/NUDT16/PFKP/LSM3/PFKM/DIS3/PARN/EXOSC10/MPHOSPH6/DCP1A/ENO1/PNPT1/PATL1/EXOSC7/DIS3L/TENT4A/CNOT10/EDC4/DCP1B/EDC3/EXOSC5/EXOSC2/PABPC3/PABPC5/PAN2	1.52671147128358
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	39/2751	109/9376	1.2194531429772	MAPK14/AKT1/AKT3/IFNAR1/AKT2/MAP2K2/TOLLIP/MAPK3/MAP2K1/PIK3R2/STAT1/FADD/MAPK1/RELA/MAP3K7/IRAK1/SPP1/TICAM2/TAB2/CTSK/PIK3CA/TLR4/MAP2K7/PIK3R1/TRAF6/MAPK9/IKBKG/CCL4/CCL3/CCL4L2/CD14/IL1B/MAPK12/TLR7/CHUK/MAPK11/TAB1/MAPK10/IL6	1.48498977972411
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	12/2751	28/9376	1.46066365477489	HSD17B12/HACD3/ELOVL1/ECHS1/ELOVL3/PPT2/HADH/ELOVL6/ELOVL4/MECR/ACOT4/ACOT2	1.57304665929669
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	13/2751	31/9376	1.42925153316682	ACO1/ACAT1/ACO2/CAT/GRHPR/SHMT2/CS/MDH1/MCEE/DLD/MMUT/ACSS2/PCCB	1.54255636163168
NA	NA	hsa04981	Folate transport and metabolism	13/2751	31/9376	1.42925153316682	MTR/ABCC1/ABCC3/MTHFS/SHMT2/FOLR2/ABCC5/FPGS/BHMT2/DHFR2/SLCO2B1/ABCC4/SLC46A1	1.54255636163168
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	42/2751	119/9376	1.20289948040285	MAP3K5/MMP14/MAPK14/CREB3L2/AKT1/AKT3/XIAP/CSF1/DAB2IP/AKT2/MAPK3/MAP2K1/PIK3R2/FADD/MAPK1/ATF6B/RELA/MAP3K7/ATF2/CREB3L1/BAG4/IL15/TAB2/CREB3/PIK3CA/TNFRSF1B/MAP2K7/PIK3R1/CREB1/RHBDF1/MAPK9/IKBKG/CASP7/IL1B/MAPK12/RPS6KA4/CHUK/MAPK11/CXCL1/TAB1/MAPK10/IL6	1.43534822240376
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	48/2751	138/9376	1.18546615459991	ADCY1/PGR/PPP2R1A/MAPK14/IGF1R/PPP2CB/PPP2CA/CDC27/FBXW11/CALM3/PPP2R5E/RPS6KA2/ADCY3/MAPK3/ADCY9/MAP2K1/MAD1L1/MAPK1/PRKACA/CUL1/PRKACB/PPP3CB/CDC16/PPP2R1B/AR/CAMK2D/PPP2R5B/CPEB4/ANAPC7/ANAPC11/BTRC/PPP2R5D/ANAPC10/CPEB1/PPP3CC/YWHAB/ANAPC2/MAD2L2/MAPK12/CDC23/ANAPC4/ADCY2/IGF1/ADCY6/MAPK11/CALM2/CAMK2A/RPS6KA6	1.41433804507534
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	54/2751	157/9376	1.17225235988303	TGFBR1/TGFBR2/MAPK14/NFATC4/AKT1/AKT3/SMAD2/FBXW11/CALM3/MRAS/HRAS/AKT2/RAD50/FOXO1/MAP2K2/CAPN1/MAPK3/MAP2K1/PIK3R2/CDK4/VDAC1/GADD45G/MAPK1/RELA/VDAC3/CHEK2/PPP3CB/RBL2/HIPK2/RAF1/NBN/PPID/RRAS/PIK3CA/MTOR/TRAF3IP2/E2F4/LIN37/IGFBP3/TSC2/BTRC/PIK3R1/RHEB/ATR/PPP3CC/CCND2/MAPK12/LIN52/MCU/MAPK11/HLA-A/CALM2/IL6/HLA-C	1.40252655023436
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	20/2751	52/9376	1.3108519978749	ADCY1/IGF1R/INSR/SCARB1/ADCY3/ADCY9/PRKACA/PRKACB/CYP1B1/LDLR/STAR/PLA2G4D/ADCY2/IGF1/ACOT4/PLA2G4C/ADCY6/GNAS/PLA2G4B/ACOT2	1.44841226742845
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	65/2751	193/9376	1.14784449554849	ADCY1/BCAR1/GNG4/SRC/SHC1/AKT1/AKT3/CRK/ROCK2/GNAI1/CXCL12/GNG12/RASGRP2/BAD/HRAS/AKT2/GRK5/GNB2/GRK3/ADCY3/STAT5B/GNB1/MAPK3/ADCY9/MAP2K1/CRKL/PIK3R2/STAT1/MAPK1/RELA/PRKACA/GNB5/GNAQ/PRKACB/SHC3/RAF1/SOS1/CXCL14/PIK3CA/CCL28/ARRB1/PIK3R1/PARD3/IKBKG/CCL4/PLCG2/CCL3/CCL8/CCL4L2/RHOA/PLCG1/CCL13/RAC3/RAP1B/CCR10/ADCY2/CHUK/ADCY6/CXCL1/VAV2/SHC2/CCL26/CCL23/ELMO1/CXCL13	1.33730206192255
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	77/2751	232/9376	1.13117487057998	PIP5K1C/PDGFRB/ITGB8/ITGB5/ITGA1/PDGFRA/LPAR1/BCAR1/NCKAP1/WASF2/SRC/AKT1/GNA12/AKT3/CRK/ROCK2/EGFR/ARPC1A/CXCL12/PPP1R12C/ARHGEF12/GNG12/MRAS/HRAS/AKT2/MAP2K2/FGF2/WASL/F2R/PIP4K2B/MAPK3/SLC9A1/MAP2K1/CRKL/PIK3R2/BDKRB2/ARAF/MAPK1/SSH1/CFL2/MSN/VCL/ITGAV/PFN2/ITGA3/ARHGAP35/DOCK1/CYFIP1/RAF1/SOS1/RRAS/APC/BRK1/PIK3CA/MYH9/LIMK1/ARHGEF7/GSN/ACTG1/PIK3R1/PAK3/MYL9/BAIAP2/MYL5/ITGB3/RHOA/ITGAE/FGF7/RAC3/BDKRB1/PDGFC/WASF1/VAV2/FGF10/MYLK3/PDGFD/ITGA2B	1.30366053998744
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	19/2751	50/9376	1.2951217739004	SMOX/MAOB/PYCR2/P4HA2/OAT/SRM/P4HA3/P4HA1/MAOA/LAP3/GOT2/CKB/ALDH18A1/ALDH3A2/PYCR3/ARG1/ALDH1B1/GAMT/CKMT2	1.34826897582735
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	72/2751	217/9376	1.13083637789024	ADCY1/PGR/CREB3L2/SRC/AKT1/ESR1/AKT3/DLL1/XIAP/KPNA6/KPNB1/GNAI1/EGFR/BAD/HRAS/VEGFA/PAQR7/AKT2/MAP2K2/RPS6KA2/FGF2/ADCY3/STAT5B/MAPK3/ADCY9/MAP2K1/PIK3R2/MAPK1/ATF6B/RELA/PRKACA/KPNA1/PRKACB/CYP1B1/EPHX1/ATF2/MGST2/CREB3L1/GSTT2B/PPARA/AIP/RAF1/SOS1/AR/RPS6KB1/GSTM3/CREB3/PIK3CA/KPNA3/PRKCA/MTOR/ARNT/ARRB1/PIK3R1/RXRB/CREB1/GSTA4/WNT1/FGF7/MGST1/CACNA1C/KLF4/GSTM5/ADCY2/GSTM4/ADCY6/EPHX2/KPNA5/FGF10/GNAS/HSP90B1/RPS6KA6	1.25652849563431
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	40/2751	116/9376	1.17524661878439	ADCY1/GNG4/GNAI1/GNG12/GNB2/GRK3/ADCY3/GNB1/MAPK3/ADCY9/MAPK1/PLD1/PRKACA/GNB5/GNAQ/PRKACB/PPP3CB/SLC1A2/HOMER3/NCDN/TRPC1/PRKCA/GNAO1/GRIA3/PPP3CC/HOMER2/SLC1A1/HOMER1/DLG4/CACNA1C/PLA2G4D/LZTS3/ADCY2/PLA2G4C/ADCY6/SHANK2/GNAS/PLA2G4B/GRIK2/GRIN3B	1.22380194978165
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	9/2751	21/9376	1.46066365477489	AASDHPPT/COASY/ENPP1/PANK3/BCAT1/ALDH3A2/BCAT2/DPYD/ALDH1B1	1.36178859420467
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	11/2751	27/9376	1.38853211626749	ACAT1/ALDH5A1/HMGCL/ECHS1/ABAT/OXCT1/OXCT2/HADH/ACADS/EHHADH/ACSM5	1.30275940727989
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	15/2751	39/9376	1.3108519978749	MTR/AHCY/AHCYL1/MTHFS/ATIC/SHMT2/MAT2B/MTHFD1L/ALDH1L2/DLD/BHMT2/DHFR2/SARDH/DMGDH/AHCYL2	1.2534882842277
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	28/2751	79/9376	1.20797500563662	CLTC/AP2A1/AP2B1/ATP6V1E1/STXBP1/VAMP2/ATP6V0A1/AP2M1/AP2A2/NSF/NAPA/ATP6V1A/ATP6V1D/SLC1A2/ATP6V1C1/UNC13B/STX2/CLTCL1/CLTA/SLC1A1/ATP6V1G1/ATP6V0E2/CLTB/RAB3A/STX1B/ATP6V0E1/ATP6V1G2/DNM1	1.19616548548887
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	70/2751	214/9376	1.11483674585622	GNG4/MAPK14/NFATC4/AKT1/GNA11/AKT3/CRK/BCL2L1/GNAI1/FBXW11/GNG12/CALM3/BAD/AP1M1/HRAS/AKT2/CUL4B/GNB2/MAP2K2/GNB1/MAPK3/MAP2K1/CRKL/PIK3R2/FADD/MAPK1/CFL2/RELA/CUL1/MAP3K7/TAPBPL/GNB5/GNAQ/PPP3CB/IRAK1/RAF1/CD4/RPS6KB1/TAB2/PIK3CA/CUL5/PRKCA/LIMK1/TNFRSF1B/MTOR/TLR4/MAP2K7/BTRC/PIK3R1/GNAO1/BAK1/TRAF6/PAK3/MAPK9/IKBKG/ATR/PLCG2/PPP3CC/PLCG1/MAPK12/RAC3/ELOB/CHUK/CASP9/MAPK11/HLA-A/TAB1/MAPK10/CALM2/HLA-C	1.09504158562203
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	29/2751	83/9376	1.19082217638274	HSD17B4/MPV17/HMGCL/CAT/PEX6/CRAT/PEX19/ABCD3/PMVK/PEX2/PEX26/GNPAT/PEX16/IDH1/PEX5/ABCD1/PEX11B/AMACR/AGPS/ABCD4/PEX10/PEX11A/PEX12/PRDX5/NUDT12/EHHADH/SLC25A17/EPHX2/ACOX2	1.12519531314619
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	29/2751	83/9376	1.19082217638274	ADAR/MAVS/DNASE2/G3BP1/POLR2E/FADD/RELA/POLR2K/DDX41/GSDMD/ZDHHC1/POLR3H/POLR3GL/IKBKG/CCL4/CASP7/POLR3B/CCL4L2/POLR3D/IL1B/POLR3A/POLR1C/ZDHHC11B/PCBP1/CHUK/POLR2L/POLR3F/ZDHHC11/IL6	1.12519531314619
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	7/2751	16/9376	1.4910941475827	MAOB/ALDH3B1/MAOA/GOT2/AOC3/MIF/IL4I1	1.26684889713295
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	7/2751	16/9376	1.4910941475827	HEXA/ST3GAL1/NAGA/A4GALT/GBGT1/B3GALNT1/B3GALT5	1.26684889713295
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	16/2751	43/9376	1.26817309561851	ACADVL/ACAT1/ECI1/ADH5/CPT1C/ECHS1/ACADSB/ALDH3A2/CPT2/ACADM/CYP2U1/ALDH1B1/HADH/ACADS/EHHADH/GCDH	1.13573443132859
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	38/2751	112/9376	1.15635872669679	LAMB2/LAMC1/LAMA4/MAPK14/AKT1/AKT3/BCL2L1/XIAP/GNAI1/BAD/AKT2/MAPK3/STAT1/IL10RB/MAPK1/RELA/MAP3K7/IRAK1/LDLR/LAMA2/TAB2/PDPK1/TLR4/LAMC3/GNAO1/TRAF6/LAMB1/MAPK9/IKBKG/MAPK12/CHUK/CASP9/MAPK11/LAMA1/BIRC7/TAB1/MAPK10/IL10	1.07267918990353
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	12/2751	31/9376	1.31930910753861	SMOX/ALDH3B1/AOC3/ECHS1/ABAT/ALDH6A1/ALDH3A2/DPYD/HIBCH/ALDH1B1/ACADS/EHHADH	1.14746775981622
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	51/2751	154/9376	1.12869464232605	ADCY1/ATP2B4/PPP2R1A/MAPK14/CREB3L2/ATP2A2/AKT1/AKT3/PPP2CB/PPP2CA/GNAI1/CALM3/AKT2/PPP2R5E/ADCY3/MAPK3/ADCY9/SLC9A1/MAPK1/ATF6B/PRKACA/GNAQ/PRKACB/SCN1B/ATF2/CREB3L1/PPP2R1B/CREB3/PRKCA/CAMK2D/PPP2R5B/PPP2R3A/CREB1/PPP2R5D/CACNA2D1/POPDC3/CACNA1C/TPM4/MAPK12/CACNB3/ADCY2/CACNA2D3/ADCY6/MYL3/MAPK11/CACNB1/GNAS/CACNB2/ATP2B3/CALM2/CAMK2A	1.03763893858288
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	51/2751	155/9376	1.12141274140782	SEC61A1/ITGB5/C3/ATP6V1E1/PLA2R1/C1R/RAB5B/VAMP3/SCARB1/ATP6AP1/DYNC1I2/TUBA3D/M6PR/ATP6V0A1/TFRC/HGS/TUBB/RAB5C/STX7/MRC2/ITGAV/TUBB6/ATP6V1A/ATP6V1D/TUBA3E/COLEC11/CANX/LAMP1/RILP/TLR4/ATP6V1C1/THBS2/RAB7A/SEC61G/ACTG1/DYNC2H1/EEA1/MRC1/ITGB3/RAB7B/CD14/ATP6V1G1/ATP6V0E2/TUBB3/CD209/HLA-A/FCGR2B/ATP6V0E1/ATP6V1G2/COLEC12/HLA-C	0.982152882141233
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	17/2751	47/9376	1.2327586873632	IRS1/HK1/INSR/IRS2/MAPK3/PIK3R2/MAPK1/HK2/PKM/PIK3CA/MTOR/PRKCE/PIK3R1/MAPK9/CACNA1G/CACNA1C/MAPK10	1.03080205065504
Human Diseases	Infectious disease: viral	hsa05162	Measles	45/2751	136/9376	1.12771826287767	AKT1/AKT3/BCL2L1/CBLB/IFNAR1/CSNK2B/ADAR/BAD/AKT2/MAVS/STAT5B/PIK3R2/CDK4/STAT1/FADD/EIF2AK2/RELA/MSN/MAP3K7/CSNK2A2/IRAK1/CDKN1B/EIF2S1/OAS2/TAB2/PIK3CA/TLR4/OAS3/PIK3R1/BAK1/TRAF6/OAS1/MAPK9/IKBKG/CCND2/RCHY1/IL1B/TLR7/CD209/CHUK/CASP9/FCGR2B/MAPK10/CD28/IL6	0.966772890253187
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	16/2751	44/9376	1.239350979809	GTF2I/TAF10/TAF9/GTF2A1/GTF2H5/GTF2F1/TAF6/TAF12/GTF2H3/ERCC3/TAF2/TAF11/TAF4/ERCC2/GTF2E1/GTF2H4	1.02544453506094
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	12/2751	32/9376	1.27808069792803	PFKL/HK1/G6PC3/GAA/PFKP/GLB1/PFKM/GALK1/HK2/B4GALT2/GANC/GALT	1.01535382948261
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	7/2751	17/9376	1.40338272713666	HSD3B7/HSD17B4/CYP7B1/AMACR/CYP27A1/ACOX2/CYP46A1	1.07266726405571
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	53/2751	163/9376	1.10819267059608	TGFBR1/TGFBR2/MAPK14/NFATC4/CREB3L2/SRC/AKT1/AKT3/IFNAR1/ATP6AP1/BAD/HRAS/AKT2/STAT6/MAP2K2/MAVS/STAT5B/MAPK3/MAP2K1/PIK3R2/STAT1/FADD/ARAF/MAPK1/ATF6B/RELA/VDAC3/MAP3K7/IRAK1/ATF2/CREB3L1/RAF1/SOS1/TICAM2/TAB2/CREB3/PIK3CA/PRKCA/TLR4/MAP2K7/PIK3R1/CREB1/TRAF6/MAPK9/IKBKG/YWHAB/MAPK12/CHUK/CASP9/MAPK11/TAB1/MAPK10/IL6	0.897902332286367
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	9/2751	23/9376	1.3336494239249	POLD2/MLH3/POLD4/SSBP1/MSH3/PMS2/MLH1/MSH2/RPA4	1.03232589711177
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	9/2751	23/9376	1.3336494239249	ACE/ANPEP/NLN/PREP/ATP6AP2/REN/THOP1/ENPEP/ACE2	1.03232589711177
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	18/2751	51/9376	1.20289948040285	PLPP3/PLD3/LPCAT2/PAFAH1B1/CHPT1/PLD1/PLPP1/PLA2G12A/ENPP2/AGPS/CEPT1/PAFAH2/PLA2G4D/PLA2G4C/PLA2G2A/SELENOI/TMEM86A/PLA2G4B	0.936223622187158
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	74/2751	233/9376	1.08243744373876	ITGB8/NID1/SUN2/NID2/SDC3/PLEC/ITGB5/ENO2/SGCB/ITGA1/TMEM43/COL5A1/COL6A3/PDLIM4/FBLN2/COL5A2/SDC2/SPTAN1/SPTBN1/AGRN/ZYX/SGCE/LMOD1/INF2/COL4A4/DAAM1/SNTA1/TLN1/TLN2/CAPZA1/VCL/COL6A1/ITGAV/COL4A6/CAPZB/ITGA3/COL4A5/SUN1/DCN/LAMA2/COL6A2/FHL1/PDLIM2/AMPD3/PDLIM1/ENO1/FBN2/FBLN1/MYH9/VCAN/DTNA/THBS2/COL5A3/SYNPO2/ACTG1/COL4A3/MYL9/FBN1/MYL5/ITGB3/TPM4/SNTB1/TNNT3/COL3A1/TMOD2/SPTBN4/COL1A2/FLNC/MYL3/CAPN3/LAMA1/COL24A1/DAAM2/ITGA2B	0.821100107930397
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	15/2751	42/9376	1.21721971231241	SLC40A1/SLC39A14/NCOA4/MAP1LC3A/PRNP/TFRC/VDAC3/SLC11A2/PCBP2/GSS/ATG7/PCBP1/GPX4/ALOX15/STEAP3	0.909134153399252
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	13/2751	36/9376	1.23074437578254	GPI/HK1/G6PC3/GYS1/GAA/PYGM/GBE1/ENPP1/HK2/PGM2L1/GYG1/GANC/PYGB	0.893813538506728
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	46/2751	142/9376	1.10406971088618	TGFBR1/TGFBR2/MAPK14/ATP2A2/AKT1/AKT3/IFNAR1/CSF1/IL1R1/AKT2/MITF/MAPK3/MAP2K1/PIK3R2/STAT1/FYN/MAPK1/RELA/MAP3K7/PPP3CB/GAB2/CSF1R/TAB2/TNFRSF11B/CTSK/PIK3CA/MAP2K7/PIK3R1/CREB1/TRAF6/SIRPA/MAPK9/IKBKG/FOSL2/PLCG2/PPP3CC/ITGB3/TMEM64/IL1B/MAPK12/CHUK/MAPK11/LILRB5/FCGR2B/TAB1/MAPK10	0.805214482079889
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	32/2751	97/9376	1.12435965178548	ADCY1/GNG4/GNAI1/GNG12/CALM3/GNB2/ADCY3/GNB1/MAPK3/ADCY9/MAPK1/PRKACA/GNB5/GNAQ/PRKACB/PRKCA/CAMK2D/GNAO1/CREB1/GRIA3/CACNA1G/CACNA1C/GUCY1A2/ADCY2/PER3/CACNA1H/ADCY6/RYR1/GNAS/KCNJ5/CALM2/CAMK2A	0.793327975310008
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	17/2751	49/9376	1.18244200624634	MAOB/GPSM1/CREB3L2/GNAI1/MAOA/ATF6B/RELA/PRKACA/PRKACB/ATF2/CREB3L1/CREB3/CDK5/CREB1/DLG4/GNAS/GRIN3B	0.825068265255171
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	22/2751	65/9376	1.15354975812991	PLPP3/AGPAT1/PNPLA2/GPAT4/AGPAT2/DGAT1/LPIN1/PLPP1/AKR1A1/ABHD16A/MGLL/MBOAT2/AGPAT3/AGPAT5/ALDH3A2/LCLAT1/ALDH1B1/AGK/DGKH/DGKQ/TKFC/GPAM	0.800471075831078
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	16/2751	46/9376	1.18546615459991	PSMD3/PSMD2/PSME3/PSMC3/PSMD1/ADRM1/PSMC2/PSMB7/PSMB4/PSMF1/PSMC4/PSMC5/PSMC1/PSMB5/PSMD8/PSMA7	0.81253252339107
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/2751	12/9376	1.42008966436447	VKORC1L1/VKORC1/COQ4/NQO1/COQ5	0.938296095574293
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	20/2751	59/9376	1.15532718456771	DCTD/NME4/CMPK1/RRM1/TK2/ENPP1/NME1/HDDC2/DUT/ENTPD6/CANT1/NT5C3B/DTYMK/DPYD/UMPS/DHODH/CMPK2/AK9/CTPS2/ENTPD3	0.771211364280005
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	21/2751	63/9376	1.13607173149158	CUL4B/POLD2/RAD23A/RAD23B/POLR2E/CETN2/ERCC5/POLD4/POLR2K/GTF2H5/POLR2B/POLR2I/ERCC1/POLR2M/GTF2H3/ERCC3/ERCC4/POLR2L/ERCC2/RPA4/GTF2H4	0.698282851125401
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	32/2751	99/9376	1.10164531538577	ITGB8/ITGB5/SGCB/ITGA1/ACE/ATP2A2/SGCE/PRKAG1/SNTA1/PRKAA1/ITGAV/ITGA3/LAMA2/DTNA/ACTG1/CACNA2D1/ITGB3/PRKAA2/CACNA1C/PRKAB1/TPM4/PRKAB2/SNTB1/CACNB3/CACNA2D3/IGF1/MYL3/CACNB1/LAMA1/CACNB2/IL6/ITGA2B	0.655147636831739
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	10/2751	28/9376	1.21721971231241	ATP6V1E1/ATP6V0A1/ATP6V1A/ATP6V1D/SLC12A7/ATP6V1C1/ATP6V1G1/ATP6V0E2/ATP6V0E1/ATP6V1G2	0.741748864371328
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	24/2751	73/9376	1.12050910503279	MLLT1/MAP1A/MAP1B/SERINC3/PDCD6IP/HGS/MDFIC/PIN1/XPO1/NELFE/VPS4A/MAP1S/CHMP4A/BICD1/TSG101/TNPO3/CD4/BICD2/CPSF7/NELFB/CCNT2/KAT2A/MLLT3/PPIA	0.666051441907284
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	14/2751	41/9376	1.16378079811332	SRC/EGFR/HRAS/VEGFA/MAP2K2/MMP2/MAPK3/MAP2K1/CDK4/ARAF/MAPK1/DAPK3/RAF1/RASSF1	0.677229304751764
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	22/2751	67/9376	1.1191154369917	ADCY1/CALM3/HRAS/MAP2K2/RPS6KA2/MAPK3/MAP2K1/ARAF/MAPK1/PRKACA/GNAQ/PRKACB/PPP3CB/RAF1/PRKCA/CAMK2D/PPP3CC/CACNA1C/RAP1B/CALM2/CAMK2A/RPS6KA6	0.630509924052933
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	33/2751	103/9376	1.09195244094822	PPP2R1A/PPP2CB/PPP2CA/NCBP2/PPP2R5E/WDR82/UPF1/NUDT21/DAZAP1/CPSF2/UPF2/TARDBP/SMG6/CASC3/PPP2R1B/CPSF7/SYMPK/SMG5/PPP2R5B/PPP2R3A/GSPT2/PPP2R5D/MAGOHB/CPSF1/CPSF3/CSTF1/CSTF3/CSTF2T/DDX19B/GLE1/PABPC3/PABPC5/NXT2	0.604657907730342
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/2751	38/9376	1.16596835600452	AOX1/NADK/NAPRT/ENPP1/NMRK1/SARM1/NADK2/SIRT6/NUDT12/SIRT3/NNMT/NMNAT1/SIRT5	0.660584147971253
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	11/2751	32/9376	1.17157397310069	BCL2L1/XIAP/FADD/BOK/BAK1/MAPK9/HTRA2/CASP7/CASP9/BIRC7/MAPK10	0.626466676491233
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	33/2751	105/9376	1.07115334683492	ITGB8/ADCY1/ITGB5/SGCB/ITGA1/ATP2A2/SGCE/ADCY3/ADCY9/SNTA1/PRKACA/ITGAV/PRKACB/ITGA3/LAMA2/DTNA/ACTG1/CACNA2D1/ITGB3/CACNA1C/TPM4/SNTB1/CACNB3/ADCY2/CACNA2D3/IGF1/ADCY6/MYL3/CACNB1/LAMA1/GNAS/CACNB2/ITGA2B	0.472459606457561
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	36/2751	115/9376	1.06691953913992	ADCY1/GNG4/CREB3L2/AKT1/GNA11/AKT3/GNAI1/GNG12/HRAS/AKT2/GNB2/ADCY3/GNB1/MAPK3/ADCY9/MAP2K1/PIK3R2/FYN/MAPK1/PRKACA/GNB5/GNAQ/PRKACB/CREB3L1/CREB3/PIK3CA/PRKCA/CAMK2D/PIK3R1/GNAO1/CREB1/CACNA1C/KCNQ3/ADCY2/ADCY6/CAMK2A	0.465276278942278
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	23/2751	72/9376	1.0887354093461	MAPK14/AZI2/ADAR/ZNFX1/MAVS/FADD/PIN1/RELA/MAP3K7/SIKE1/TRIM25/TRAF6/MAPK9/IKBKG/ISG15/MAPK12/DHX58/TKFC/CHUK/NLRX1/MAPK11/TBKBP1/MAPK10	0.487041924170187
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	12/2751	36/9376	1.13607173149158	GALNT15/ST3GAL1/C1GALT1/GALNT11/GCNT1/GALNT17/GALNT13/GALNT18/GCNT4/ST6GALNAC4/ST6GALNAC2/C1GALT1C1L	0.527088711925287
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	22/2751	69/9376	1.08667730838325	MAOB/CREB3L2/CALM3/MAOA/ATF6B/PRKACA/PRKACB/PPP3CB/ATF2/CREB3L1/CREB3/PRKCA/CAMK2D/HDAC2/CREB1/GRIA3/PPP3CC/CACNA1C/GNAS/CALM2/CAMK2A/GRIN3B	0.465653741763975
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/2751	20/9376	1.19287531806616	LSS/SOAT1/CYP51A1/LIPA/NSDHL/TM7SF2/SOAT2	0.556396691149813
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/2751	20/9376	1.19287531806616	CYB5R3/UGDH/GMPPA/GMPPB/GNE/TGDS/NANP	0.556396691149813
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	28/2751	89/9376	1.0722474769134	LAMB2/ITGB8/TNXB/GP1BB/ITGB5/LAMC1/ITGA1/LAMA4/COL6A3/AGRN/VTN/COL4A4/COL6A1/ITGAV/COL4A6/SPP1/ITGA3/COL4A5/LAMA2/COL6A2/LAMC3/THBS2/LAMB1/COL4A3/ITGB3/COL1A2/LAMA1/ITGA2B	0.441283772782046
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/2751	56/9376	1.09549774108117	C3/BNIP3/HSF1/RAB1B/SAR1B/VCP/RELA/RAB1A/SAR1A/TLR4/ARF1/CASP7/CD14/IL1B/CASP9/CXCL1/EEF1G/IL6	0.461867228504091
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	66/2751	216/9376	1.04139908720061	MAP3K5/ERO1A/MAPK14/SRC/AKT1/AKT3/BCL2L1/ROCK2/CALM3/BAD/HRAS/AKT2/ATF6/MAPK3/PIK3R2/VLDLR/MIB1/MIB2/MAPK1/RELA/MAP3K7/PPP3CB/IRAK1/HSPA2/EIF2S1/LDLR/ABCA1/TICAM2/TAB2/PDPK1/PIK3CA/PRKCA/CAMK2D/TLR4/APOA1/NFE2L2/MAP2K7/PIK3R1/RXRB/TRAF6/MAPK9/IKBKG/CASP7/PPP3CC/CCL3/RHOA/PLCG1/CD14/IL1B/MAPK12/RAP1B/CHUK/CASP9/CASP6/MAPK11/CXCL1/VAV2/CYP2A6/CYP2A7/TAB1/MAPK10/TNFRSF10A/CALM2/IL6/CAMK2A/HSP90B1	0.39665039982666
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	24/2751	76/9376	1.07627848246571	FADS2/ILK/PLTP/SORBS1/SCD5/SCD/PPARA/CPT1C/PDPK1/APOA1/ANGPTL4/PLIN1/RXRB/CYP27A1/ME1/PPARD/CPT2/SLC27A1/ACADM/SLC27A4/EHHADH/PCK2/ME3/ACOX2	0.430234624089615
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	14/2751	43/9376	1.10965145866619	PLPP3/AGPAT1/SCARB1/AGPAT2/ACAT1/DGAT1/PLPP1/PLA2G12A/ABCA1/GOT2/APOA1/SLC27A1/SLC27A4/PLA2G2A	0.464382665850115
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	27/2751	86/9376	1.07002104942812	ITGB8/GJA1/ITGB5/SGCB/ITGA1/ATP2A2/SGCE/CTNNA1/SNTA1/ITGAV/ITGA3/LAMA2/DTNA/TCF7L2/ACTG1/CACNA2D1/ITGB3/CACNA1C/SNTB1/CACNB3/CDH2/CACNA2D3/CACNB1/LAMA1/CACNB2/ITGA2B/TCF7L1	0.420347023116285
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/2751	17/9376	1.20289948040285	TFRC/PCDH20/LAMP1/MYH9/CD209/PCDH9	0.539546232103081
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	20/2751	63/9376	1.08197307761103	GGT5/CBR1/PTGR1/PLA2G12A/PTGES2/PTGIS/ALOX15B/PRXL2B/CBR3/CYP2U1/PLA2G4D/PTGR2/PLA2G4C/HPGDS/PLA2G2A/EPHX2/GPX4/PTGDS/PLA2G4B/ALOX15	0.420663378956815
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/2751	14/9376	1.21721971231241	ST3GAL1/CHST2/CHST1/B4GALT3/B4GALT2	0.524103337986932
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	12/2751	37/9376	1.10536709009991	MAOB/AOX1/ALDH3B1/MAOA/ADH5/GOT2/AOC3/FAH/COMT/FAHD1/MIF/IL4I1	0.413803017076351
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	14/2751	44/9376	1.08443210733287	MPG/POLD2/POLD4/PARP4/APEX1/UNG/PARP3/SMUG1/POLL/NTHL1/NEIL2/APTX/PARG/OGG1	0.361730054822683
Human Diseases	Substance dependence	hsa05032	Morphine addiction	28/2751	91/9376	1.04868159829992	ADCY1/GNG4/PDE8B/GNAI1/GNG12/GRK5/GNB2/GRK3/ADCY3/GNB1/ADCY9/PRKACA/GNB5/PDE8A/PRKACB/PDE10A/PRKCA/ARRB1/GNAO1/GABRB3/ADCY2/PDE1A/ADCY6/GABBR1/GNAS/KCNJ5/PDE3A/GABRA3	0.30069940076237
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	13/2751	41/9376	1.08065359824809	MAOB/PGAM1/MAOA/GRHPR/SHMT2/AOC3/DLD/SDSL/SARDH/GAMT/PSPH/DMGDH/SRR	0.333500513469756
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	9/2751	28/9376	1.09549774108117	CBR1/PCBD1/MOCS2/FPGS/DHFR2/SPR/PCBD2/MOCS1/GPHN	0.326099966908648
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	23/2751	75/9376	1.04518599297225	CD82/BCL2L1/SESN3/CCNG2/EI24/SHISA5/CDK4/GADD45G/TP53I3/CHEK2/AIFM2/ZMAT3/IGFBP3/TSC2/ATR/CCND2/COP1/RCHY1/IGF1/GORAB/CASP9/STEAP3/TNFRSF10A	0.253167312888454
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/2751	15/9376	1.13607173149158	AK4/AK2/NTPCR/AK1/NFS1	0.339852453948415
Organismal Systems	Endocrine system	hsa04924	Renin secretion	21/2751	69/9376	1.03728288527492	ACE/GNAI1/CALM3/NPR1/CTSB/PRKACA/GNAQ/PRKACB/PPP3CB/EDNRA/CREB1/PPP3CC/REN/CACNA1C/GUCY1A2/PDE1A/ADCY6/GNAS/KCNMA1/CALM2/PDE3A	0.200293656504203
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	26/2751	86/9376	1.03039064019004	ADCY1/CREB3L2/VAMP2/GNA11/SLC2A1/ADCY3/ADCY9/ATF6B/PRKACA/GNAQ/PRKACB/ATF2/CREB3L1/CREB3/PRKCA/CAMK2D/CREB1/TRPM4/CACNA1C/ADCY2/ADCY6/KCNMB4/GNAS/RAB3A/KCNMA1/CAMK2A	0.182439641205245
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	8/2751	26/9376	1.04868159829992	ABCC1/SCARB1/APOA1/BTD/ABCD4/SLC46A1/TCN2/CUBN	0.160170926987801
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	34/2751	115/9376	1.00764623140992	GNG4/MAOB/GNAI1/GNG12/HTR2B/HRAS/GNB2/GNB1/MAPK3/MAP2K1/MAOA/ARAF/MAPK1/PRKACA/GNB5/GNAQ/PRKACB/APP/RAF1/TRPC1/PRKCA/GNAO1/ALOX15B/GABRB3/CACNA1C/PLA2G4D/KCND2/PLA2G4C/HTR2A/GNAS/PLA2G4B/ALOX15/DUSP1/KCNJ5	0.0531625014766123
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	46/2751	156/9376	1.00498653170409	PPP2R1A/AKT1/AKT3/PPP2CB/SCARB1/PPP2CA/IFNAR1/EGFR/PSME3/BAD/HRAS/AKT2/MAP2K2/MAVS/MAPK3/MAP2K1/PIK3R2/CDK4/STAT1/PIAS1/FADD/EIF2AK2/ARAF/MAPK1/RELA/EIF2S1/LDLR/PPARA/RAF1/PPP2R1B/SOS1/OAS2/PIK3CA/OAS3/CD81/EIF3E/RNASEL/PIK3R1/BAK1/TRAF6/OAS1/IKBKG/CLDN12/YWHAB/CHUK/CASP9	0.0404700196579018
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	16/2751	54/9376	1.00984153910363	ERCC1/POLK/TELO2/PMS2/REV3L/POLI/ATR/MLH1/FAN1/ATRIP/ERCC4/FAAP100/RPA4/PALB2/POLH/FANCG	0.0467351181667292
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	53/2751	181/9376	0.997985664680448	C3/MAPK14/SRC/PLA2R1/AKT1/AKT3/RAB5B/ATP6AP1/ARHGEF12/CALM3/BAD/AKT2/ATP6V0A1/KSR1/MAPK3/STAT1/FADD/IL10RB/CARD9/RAB5C/MAPK1/RELA/MRC2/PPP3CB/IRAK1/SPHK1/RAF1/LAMP1/CAMK2D/TLR4/RAB7A/CREB1/TRAF6/SPHK2/EEA1/MAPK9/MRC1/PPP3CC/CTSD/RHOA/CD14/IL1B/MAPK12/CD209/CASP9/MAPK11/RFX5/FCGR2B/MAPK10/CALM2/IL6/CAMK2A/IL10	-0.017633283115887
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	11/2751	37/9376	1.01325316592492	ASS1/ASL/GFPT1/ALDH5A1/ADSL/NIT2/GOT2/GFPT2/ABAT/PPAT/IL4I1	0.0520485100266664
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	22/2751	75/9376	0.999743123712589	ADCY1/CREB3L2/ADCY3/ADCY9/PDIA4/GPX8/ATF6B/PRKACA/GNAQ/PRKACB/ATF2/CREB3L1/CANX/CREB3/PRKCA/GPX7/CREB1/ADCY2/ADCY6/GNAS/TG/HSP90B1	-0.00143922209407804
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	24/2751	82/9376	0.99752639838285	NME4/CES1/IMPDH2/CMPK1/RRM1/TK2/NME1/MGST2/CES2/GSTT2B/IMPDH1/GSTM3/DUT/HPRT1/GSTA4/DPYD/TPMT/UMPS/MGST1/GSTM5/GSTM4/CYP2A6/CYP2A7/NAT1	-0.0144968398230955
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	26/2751	89/9376	0.995658371419586	ADCY1/GNG4/SRC/GNAI1/GNG12/GNB2/ADCY3/GNB1/ADCY9/PLCL1/NSF/PRKACA/GNB5/PRKACB/PRKCA/TRAK2/GNAO1/ABAT/SLC38A5/GABRB3/CACNA1C/ADCY2/ADCY6/GABBR1/GPHN/GABRA3	-0.026518438038742
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	46/2751	158/9376	0.992265183201506	ABL1/PPP2R1A/PPP2CB/PPP2CA/CDC27/SMAD2/PDS5A/PPP2R5E/CDK4/GADD45G/MAD1L1/CUL1/PDS5B/CHEK2/RBL2/CDKN1B/ATRX/MAU2/CDC16/PPP2R1B/HDAC2/E2F4/ORC3/PPP2R5B/ANAPC7/ANAPC11/STAG1/FZR1/CDC14B/MAD2L1BP/CDC25B/PPP2R5D/ATR/ANAPC10/ZBTB17/YWHAB/CCND2/ANAPC2/CDC7/ORC5/MAD2L2/CDC23/ANAPC4/MCM6/NDC80/MCM5	-0.063182705043448
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/2751	13/9376	1.04868159829992	RAD50/XRCC6/POLL/POLM	0.113179295158527
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	57/2751	196/9376	0.991164622882959	C3/GNG4/MAPK14/NFATC4/SRC/AKT1/AKT3/IFNAR1/MAP1LC3A/GNG12/CALM3/HRAS/VEGFA/AKT2/GNB2/MAP2K2/FGF2/GNB1/MAPK3/MAP2K1/PIK3R2/CDK4/STAT1/FADD/EIF2AK2/MAPK1/RELA/GNB5/PPP3CB/RAF1/MICA/PIK3CA/MTOR/TCF7L2/MAP2K7/PIK3R1/CREB1/BAK1/MAPK9/IKBKG/PLCG2/PPP3CC/RCAN1/PLCG1/MAPK12/CHUK/CASP9/MAPK11/CXCL1/CD200R1/HLA-A/MAPK10/CALM2/IL6/HLA-C/TCF7L1/ZFP36	-0.0805507852005246
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	12/2751	41/9376	0.99752639838285	BABAM2/RAD50/POLD2/POLD4/BABAM1/SSBP1/NBN/RAD52/ABRAXAS1/RPA4/RAD51B/PALB2	-0.0102282778122525
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	52/2751	180/9376	0.984595500626035	DAXX/C3/PTPN11/SRC/AKT1/AKT3/BCL2L1/IFNAR1/BAD/AKT2/MAVS/PIK3R2/STAT1/FADD/NECTIN2/EIF2AK2/CARD9/RELA/HCFC2/MAP3K7/TAPBPL/IRAK1/PML/EIF2S1/OAS2/TAB2/PIK3CA/MTOR/OAS3/PILRA/HCFC1/EIF2B4/TSC2/RNASEL/PIK3R1/BAK1/EIF2B3/TRAF6/OAS1/EIF2B5/RHEB/IKBKG/ITGB3/NECTIN1/IL1B/EIF2B2/CHUK/CASP9/HLA-A/TAB1/IL6/HLA-C	-0.134469054815014
Cellular Processes	Cell motility	hsa04814	Motor proteins	56/2751	194/9376	0.983814695312295	MYO1C/DCTN1/KLC1/MYO10/ACTR1A/ACTR1B/DYNC1I2/TUBA3D/KIF13A/DYNLT3/MYO1B/DCTN6/MYO9A/KIFAP3/TUBB/CAPZA1/DYNLRB1/MYO5A/DCTN5/KIF3B/TUBB6/MYL6B/DCTN3/ACTR10/CAPZB/TUBA3E/KIF1C/KIF5B/DCTN4/MYH9/TUBG2/TUBE1/TUBG1/KIF16B/KIF22/KIFC3/ACTG1/DYNC2LI1/DYNC2H1/MYL9/KIF7/MYL5/DNAH11/TPM4/DNAL1/KLC2/TUBB3/TNNT3/MYO1D/MYO16/DNAL4/MYL3/KLC4/MYO18A/KIF5A/DNAH14	-0.146788182182567
NA	NA	hsa04081	Hormone signaling	63/2751	219/9376	0.980445466903691	ADRA2C/PRLR/ADCY1/IRS1/GNG4/SLC40A1/IGF1R/SRC/INSR/GNA12/ESR1/GNA11/GNAI1/IRS2/GNG12/HEPH/GNB2/ADCY3/STAT5B/GNB1/ADCY9/PIK3R2/NPR1/NPR2/SMAD5/PRKACA/GNB5/GNAQ/APPL1/ITGAV/SMAD9/PRKACB/RAMP3/EPOR/STK11/THRA/PIK3CA/BMPR1A/NPR3/PIK3R1/GNAO1/CRHR1/ACVR1/ITGB3/GHR/RAMP1/RHOA/LEPR/OXT/VIPR2/AVPR1A/PRL/ADCY2/IGF1/SLC16A2/ADCY6/OPRL1/GNAS/THPO/MC1R/ADRA2A/GAST/GNA14	-0.18868218339493
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	73/2751	254/9376	0.979526414160062	PDGFRB/ADCY1/ATP2B4/KDR/PDGFRA/EDNRB/NFATC4/ATP2A2/GNA11/EGFR/PLCD1/CALM3/HTR2B/STIM1/VEGFA/FGF2/ADCY3/F2R/ADCY9/ITPKC/VEGFB/VDAC1/BDKRB2/PRKACA/VDAC3/GNAQ/PRKACB/ORAI3/PPP3CB/CAMK1/SPHK1/MCOLN1/RET/EDNRA/PLCD3/PRKCA/CAMK2D/ADORA2B/TBXA2R/NTRK1/TPCN2/SPHK2/PLCG2/PLCE1/PPP3CC/ITPKB/CACNA1G/PLCG1/FGF7/CACNA1C/TPCN1/AVPR1A/BDKRB1/PDGFC/ADCY2/PDE1A/ITPKA/HTR2A/CACNA1H/MCU/CAMK1D/FGF10/RYR1/MYLK3/GNAS/PDGFD/PHKA2/ATP2B3/CALM2/CAMK2A/GRIN3B/GNA14/P2RX6	-0.213159027482441
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	53/2751	187/9376	0.965964734262893	MFN2/PKN1/ANTXR1/MAPK14/BCL2L1/XIAP/IFNAR1/ANTXR2/MAP1LC3A/MAVS/MAPK3/SHARPIN/STAT1/FADD/VDAC1/CARD9/CTSB/MAPK1/RELA/TXN2/ERBIN/VDAC3/MAP3K7/TRIP6/GSDMD/OAS2/TAB2/TP53BP1/TLR4/OAS3/RNF31/RNASEL/TRAF6/OAS1/MAPK9/IKBKG/ATG16L1/DHX33/RHOA/IL1B/MAPK12/GBP1/CHUK/CARD6/NLRX1/MCU/MAPK11/CXCL1/TXNIP/TAB1/MAPK10/IL6/NOD1	-0.302938042911421
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	48/2751	170/9376	0.962319584322279	MAP3K5/PPP2R1A/SRC/PPP2CB/PPP2CA/ROCK2/ARPC1A/AMOTL2/PRKAG1/MPDZ/TUBA3D/CDK4/CTTN/JAM3/PRKAA1/MSN/PRKACA/PRKACB/NF2/RAB13/MYL6B/STK11/TUBA3E/SYNPO/PPP2R1B/MYH9/SYMPK/PRKCE/ARHGEF18/MAP2K7/ACTG1/PARD3/MYL9/PRKCI/MAPK9/CLDN12/SCRIB/RHOA/PRKAA2/PRKAB1/PRKAB2/MICALL2/MAGI1/PARD6G/MAPK10/DLG3/EPB41L4B/CGN	-0.319479247362141
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	58/2751	205/9376	0.964275518436755	NCOR2/MAPK14/PSMD3/AKT1/AKT3/PSMD2/IFNAR1/AKT2/PSMC3/PSMD1/ADRM1/MAVS/PIK3R2/CDK4/STAT1/RBPJ/FADD/PSMC2/EIF2AK2/GADD45G/RELA/PSMC4/MAP3K7/TAPBPL/USP7/PSMC5/IRAK1/CDKN1B/PSMC1/SAP30L/POLK/SAP30/OAS2/TAB2/PIK3CA/HDAC2/OAS3/MAP2K7/PIK3R1/BAK1/TRAF6/OAS1/MAPK9/IKBKG/ISG15/PLCG2/PSMD8/CCND2/MAPK12/CHUK/CASP9/MAPK11/HLA-A/ENTPD3/TAB1/MAPK10/IL6/HLA-C	-0.33325180539355
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	6/2751	22/9376	0.929513234856746	MAOB/ALDH3B1/MAOA/CARNMT1/ALDH3A2/ALDH1B1	-0.213283976704688
NA	NA	hsa03272	Virion - Hepatitis viruses	13/2751	48/9376	0.923058281836908	SCARB1/EGFR/PDCD6IP/TGOLN2/VPS4A/LDLR/CHMP4A/TSG101/LAMP1/CHMP7/CD81/CLDN12/CD63	-0.344370722884982
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	29/2751	105/9376	0.941316577521594	BCL2L1/XIAP/IL1R1/CXCL12/CSNK2B/LTBR/GADD45G/RELA/MAP3K7/CSNK2A2/IRAK1/ERC1/TICAM2/TAB2/PLAU/TLR4/TRIM25/TRAF6/IKBKG/CCL4/PLCG2/CCL4L2/PLCG1/CD14/CCL13/IL1B/CHUK/CXCL1/TAB1	-0.389659066270721
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	25/2751	91/9376	0.936322855624928	AKT1/AKT3/HRAS/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/MAPK1/RELA/PPP3CB/INPPL1/RAF1/SOS1/PIK3CA/CD81/PIK3R1/IKBKG/PLCG2/PPP3CC/RAC3/CHUK/VAV2/LILRB5/FCGR2B	-0.393324784405755
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	32/2751	116/9376	0.940197295027514	CD99L2/BCAR1/PTPN11/MAPK14/CTNND1/ROCK2/GNAI1/CXCL12/THY1/ARHGAP5/MMP2/CTNNA1/PIK3R2/JAM3/MSN/VCL/ARHGAP35/PIK3CA/PRKCA/ACTG1/PIK3R1/SIPA1/MYL9/CLDN12/PLCG2/MYL5/RHOA/PLCG1/MAPK12/RAP1B/MAPK11/VAV2	-0.417620992948162
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	56/2751	201/9376	0.949552491992961	MLLT1/WT1/PBX1/MAF/TGFBR2/ZEB1/HOXA11/IGF1R/BMI1/BCL2L1/MEIS1/PBX3/IL1R2/EWSR1/FOXO1/MITF/GADD45G/HOXA9/RELA/NUPR1/CDK14/ZBTB16/HOXA10/PML/TFE3/NCOR1/CDKN1B/ELK4/POLK/CSF1R/PLAT/PLAU/MAX/HDAC2/CCNT2/IGFBP3/RUNX1T1/SP1/NTRK1/RXRB/BAK1/BMP2K/ZBTB17/GRIA3/CCND2/CD14/MLLT3/ETV5/IGF1/NSD2/SUPT3H/TSPAN7/MEF2C/ELANE/IL6/SLC45A3	-0.46587853623818
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	63/2751	226/9376	0.950077686955347	ADCY1/ATP2B4/PTCH1/CREB3L2/ATP2A2/AKT1/AKT3/FXYD1/ROCK2/GNAI1/CALM3/BAD/AKT2/MAP2K2/ADCY3/F2R/MAPK3/ADCY9/SLC9A1/MAP2K1/PIK3R2/NPR1/MAPK1/RELA/PLD1/PRKACA/PRKACB/CREB3L1/PDE10A/PPARA/RAF1/RRAS/CREB3/EDNRA/PIK3CA/CAMK2D/PIK3R1/CREB1/CRHR1/MYL9/MAPK9/GRIA3/PLCE1/RHOA/ABCC4/POPDC3/CACNA1C/RAC3/OXT/RAP1B/VIPR2/ADCY2/ADCY6/VAV2/GABBR1/GNAS/MAPK10/HCN2/ATP2B3/CALM2/CAMK2A/PDE3A/GRIN3B	-0.489526677009392
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	10/2751	38/9376	0.896898735388088	IRS1/INSR/MAPK3/PIK3R2/MAPK1/PDPK1/PIK3CA/PRKCA/PIK3R1/IGF1	-0.410361726042315
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/2751	12/9376	0.852053798618684	NPC1/CD209/FCGR2B	-0.330446937610676
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	12/2751	46/9376	0.889099615949931	HEPH/UROD/HMOX2/BLVRB/ALAD/PPOX/FXN/COX15/HCCS/COX10/EARS2/HMBS	-0.485857751737123
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	46/2751	168/9376	0.933201779439511	PDGFRB/PRLR/PDGFRA/PTPN11/OSMR/AKT1/IL15RA/AOX1/AKT3/SOCS5/BCL2L1/IFNAR1/EGFR/IL13RA1/HRAS/AKT2/STAM2/STAT6/STAT5B/PIK3R2/STAT1/PIAS1/IL10RB/STAM/EPOR/RAF1/FHL1/SOS1/IL15/PIK3CA/MTOR/PIK3R1/CISH/SOCS6/GHR/CCND2/PIAS3/LEPR/PRL/CTF1/IL13RA2/IL11/THPO/CSF3/IL6/IL10	-0.562956542968179
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	21/2751	79/9376	0.905981254227462	ALDH3B1/CBR1/CYP1B1/EPHX1/MGST2/GSTT2B/ADH5/AKR7A2/GSTM3/HSD11B1/GSTA4/CBR3/MGST1/CYP2S1/GSTM5/CYP3A5/GSTM4/HPGDS/CYP2A6/HSD11B1L/CYP2A7	-0.540747568862013
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	25/2751	94/9376	0.906440211296472	MAPK7/MAPK14/MAPK3/ELAVL1/FADD/USP25/MAPK1/RELA/MAP3K7/IL17RC/MAPK6/TAB2/TRAF3IP2/TRAF6/MAPK9/IKBKG/IL1B/MAPK12/CHUK/MAPK11/CXCL1/MAPK10/CSF3/IL6/HSP90B1	-0.587449270964777
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	20/2751	76/9376	0.896898735388088	ADCY1/SLC4A2/GNAI1/CALM3/ADCY3/ADCY9/SLC9A1/PRKACA/GNAQ/PRKACB/PRKCA/CAMK2D/ACTG1/ADCY2/ADCY6/MYLK3/GNAS/CALM2/GAST/CAMK2A	-0.58152354883846
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	47/2751	173/9376	0.925931295608743	AKT1/AKT3/IFNAR1/KPNA6/ADAR/RAB11B/AKT2/MAP2K2/MAVS/MAPK3/MAP2K1/PIK3R2/DNAJC3/CDK4/STAT1/FADD/VDAC1/EIF2AK2/XPO1/MAPK1/RAB11A/RELA/KPNA1/PML/EIF2S1/RAF1/OAS2/PIK3CA/PRKCA/TLR4/TRIM25/OAS3/ACTG1/RNASEL/PIK3R1/BAK1/OAS1/IKBKG/IL1B/TLR7/CHUK/CASP9/NLRX1/KPNA5/NXT2/TNFRSF10A/IL6	-0.633623214880327
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	56/2751	205/9376	0.93102463849066	C3/CREB3L2/SRC/MRPS18B/LTBR/SND1/BAD/HRAS/STAT5B/MAPK3/PIK3R2/CDK4/RBPJ/EIF2AK2/MAD1L1/MAPK1/ATF6B/RELA/PRKACA/VDAC3/GTF2A1/USP7/PRKACB/RBL2/CDKN1B/ATF2/CREB3L1/HDAC4/PSMC1/CREB3/PKM/PIK3CA/SRF/HDAC7/HDAC2/GSN/GTF2H3/PIK3R1/CREB1/BAK1/UBR4/KAT2A/IKBKG/HDAC3/HDAC11/VAC14/YWHAB/SCRIB/CCND2/RHOA/HDAC10/HLA-A/GTF2E1/GTF2H4/HDAC9/HLA-C	-0.643428896510831
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	9/2751	36/9376	0.852053798618684	POLD2/RNASEH2C/POLD4/RNASEH1/SSBP1/MCM6/RPA4/POLA1/MCM5	-0.573085767819035
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	18/2751	70/9376	0.876398192864932	CBR1/CYP1B1/EPHX1/MGST2/GSTT2B/GSTM3/HSD11B1/GSTA4/MGST1/GSTM5/CYP3A5/GSTM4/HPGDS/CYP2A6/HSD11B1L/CYP2A7/NAT1/AKR1C2	-0.668852428789889
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/2751	37/9376	0.829025317574936	LAMA4/GNAQ/APOL1/PRKCA/APOA1/IL1B/THOP1/IL6/IL10	-0.671460504072702
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	6/2751	26/9376	0.786511198724939	FADS2/PLA2G12A/PLA2G4D/PLA2G4C/PLA2G2A/PLA2G4B	-0.702415294400841
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	17/2751	68/9376	0.852053798618684	ALDH1A2/RDH10/DHRS3/AOX1/RDH11/DGAT1/PNPLA4/ADH5/ALDH1A3/CYP26B1/RETSAT/CYP2S1/HSD17B6/CYP3A5/CYP2A6/RDH5/CYP2A7	-0.788983788966701
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/2751	23/9376	0.740916346624943	ASS1/ASL/GOT2/ACY1/ARG1	-0.801616144728022
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	17/2751	70/9376	0.827709404372436	SGCB/ABL1/SGCE/EIF4G3/EIF4G1/FYN/SNTA1/LAMA2/DTNA/ACTG1/SNTB1/RAC3/CASP9/HLA-A/LAMA1/CD28/HLA-C	-0.932324421577637
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/2751	93/9376	0.842891929816333	MAF/NOTCH3/MAPK14/DLL1/STAT6/STAT5B/MAPK3/STAT1/RBPJ/MAPK1/RELA/PPP3CB/CD4/MAML2/MAPK9/IKBKG/PPP3CC/PLCG1/MAPK12/MAML3/CHUK/MAPK11/MAPK10	-0.981146333372849
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/2751	28/9376	0.730331827387444	B4GALT3/B4GALT2/A4GALT/B3GALNT1/B3GALT5/FUT4	-0.920846725479394
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	29/2751	117/9376	0.844771287519379	MBD3/CDK2AP2/SMARCA4/PHF10/SMARCE1/MEAF6/SMARCD3/SMARCC2/BCL7C/EP400/SMARCD2/SRCAP/RUVBL2/KAT5/CHD3/MTA1/VPS72/INO80B/HDAC2/ACTG1/BRD8/DMAP1/RUVBL1/ACTL6A/MRGBP/DPF1/BCL7A/NFRKB/CECR2	-1.08873187050093
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	6/2751	30/9376	0.681643038894947	PLA2G12A/PLA2G4D/PLA2G4C/PLA2G2A/PLA2G4B/ALOX15	-1.12538230331525
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/2751	17/9376	0.601449740201424	GGT5/ADO/GGT7	-1.0598168637548
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/2751	17/9376	0.601449740201424	CA12/CA9/CA5B	-1.0598168637548
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	26/2751	109/9376	0.8129687619848	TGFBR1/TGFBR2/MAPK14/IL1R1/SMAD2/STAT6/STAT5B/MAPK3/STAT1/RORA/MAPK1/RELA/PPP3CB/CD4/MTOR/RXRB/MAPK9/IKBKG/PPP3CC/PLCG1/IL1B/MAPK12/CHUK/MAPK11/MAPK10/IL6	-1.2655980824598
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	22/2751	95/9376	0.789270887141518	ATP6V1E1/CSF1/CXCL12/ATP6AP1/VEGFA/ATP6V0A1/ATP6V1A/ATP6V1D/IL15/CTSK/TLR4/ATP6V1C1/CCL3/ATP6V1G1/IL1B/ATP6V0E2/CXCL1/IL11/ATP6V0E1/ATP6V1G2/CD28/IL6	-1.33023064078855
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	10/2751	48/9376	0.710044832182237	HK1/G6PC3/AKT1/AKT3/AKT2/PIK3R2/HK2/PIK3CA/PIK3R1/SLC2A5	-1.2977624249823
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7/2751	36/9376	0.662708510036754	DCXR/UGDH/AKR1A1/CRYL1/RPE/FGGY/CRPPA	-1.30653542098192
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	16/2751	73/9376	0.74700607002186	MAOB/AOX1/ALDH3B1/MAOA/MGST2/GSTT2B/ADH5/GSTM3/GSTA4/MGST1/GSTM5/CYP3A5/GSTM4/HPGDS/CYP2A6/CYP2A7	-1.39829245109638
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/2751	50/9376	0.681643038894947	LRP1/SDC2/GYPC/TLR4/CD81/THBS2/IL1B/CSF3/IL6/IL10	-1.4544193341745
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	19/2751	87/9376	0.744322858563448	UQCRC1/ATP2A2/SLC9A1/COX7A1/CYC1/UQCRC2/COX7A2L/CACNA2D1/UQCRQ/SLC9A6/CACNA1C/TPM4/UQCR11/CACNB3/CACNA2D3/MYL3/COX6B1/CACNB1/CACNB2	-1.54384977576861
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	23/2751	103/9376	0.761057761872999	COL18A1/SLC7A8/COL5A1/COL6A3/COL5A2/COL7A1/COL4A4/COL6A1/COL4A6/COL4A5/COL6A2/COL15A1/COL5A3/COL26A1/COL4A3/COL14A1/SLC1A1/COL3A1/SLC36A1/COL1A2/COL24A1/ACE2/COL23A1	-1.57122869479497
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	22/2751	100/9376	0.749807342784442	CSF1/CXCL12/LTBR/IL10RB/CSF1R/CXCL14/CCL28/TNFRSF1B/TNFRSF10D/CCL4/CCL3/CCL8/CCL4L2/CCL13/CCR10/CXCL1/CCL26/CCL23/TNFRSF10A/IL6/IL10/CXCL13	-1.62081027705343
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/2751	61/9376	0.670468562847489	CYBRD1/ATP2B4/SLC40A1/HEPH/SLC30A1/HMOX2/SLC11A2/ATP7A/SLC26A6/SLC46A1/STEAP2/ATP2B3	-1.6638276313253
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	16/2751	78/9376	0.699121065533279	C3/MAPK14/MAPK3/STAT1/MAPK1/RELA/MAP3K7/IRAK1/TAB2/TLR4/TRAF6/IL1B/MAPK12/MAPK11/TAB1/IL10	-1.71942130985959
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/2751	31/9376	0.549712128141086	UGDH/HSD17B14/AKR1A1/ALDH3A2/ALDH1B1	-1.61815245289202
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	13/2751	66/9376	0.671315114063206	HSD17B12/SRD5A3/STS/CYP1B1/CYP7B1/COMT/HSD11B1/HSD17B6/CYP3A5/HSD17B8/RDH5/HSD11B1L/AKR1C2	-1.72669190731544
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/2751	50/9376	0.613478735005452	IL15RA/CXCL12/LTBR/IL15/CCL28/CCR10/CD28/IL6/IL10	-1.76582914639693
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	21/2751	100/9376	0.715725190839695	GP1BB/ITGA1/ANPEP/CSF1/IL1R1/IL1R2/TFRC/EPOR/ITGA3/CD4/CSF1R/CD59/ITGB3/CD14/IL1B/IL11/THPO/CSF3/IL6/KITLG/ITGA2B	-1.84160293640214
Genetic Information Processing	Translation	hsa03010	Ribosome	52/2751	222/9376	0.798320676183272	MRPS18A/MRPL24/MRPS18B/MRPL37/MRPS16/MRPL38/MRPL41/MRPL16/MRPS21/MRPS28/MRPL40/MRPL51/MRPL12/MRPL22/MRPL3/MRPS10/MRPS15/MRPS34/MRPS12/MRPL32/MRPL21/MRPS23/DAP3/MRPL54/MRPS33/MRPL50/MRPL2/MRPL42/MRPS5/MRPL20/MRPS35/MRPS6/MRPL35/RPL26L1/MRPL28/MRPL33/MRPS27/MRPS17/MRPS26/MRPS22/MRPS14/MRPS2/MRPL9/RPL35/MRPL1/MRPL10/MRPS9/RPL4/MRPL48/RPS4Y1/MRPL53/MRPL39	-1.95961340594404
Organismal Systems	Digestive system	hsa04970	Salivary secretion	19/2751	93/9376	0.69630202897871	ADCY1/SLC4A2/ATP2B4/VAMP2/CALM3/ADCY3/ADCY9/SLC9A1/PRKACA/GNAQ/PRKACB/PRKCA/GUCY1A2/ADCY2/ADCY6/GNAS/ATP2B3/KCNMA1/CALM2	-1.89660626836017
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/2751	23/9376	0.444549807974966	MDH1/PCK2/SLC25A10	-1.71858716564792
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	21/2751	102/9376	0.701691363568328	ADCY1/SLC4A2/ATP2B4/ATP2A2/ADCY3/ADCY9/SLC9A1/RAB11A/GNAQ/PLA2G12A/TRPC1/PRKCA/TPCN2/RHOA/RAP1B/ADCY2/ADCY6/PLA2G2A/GNAS/ATP2B3/KCNMA1	-1.95195750721295
Organismal Systems	Digestive system	hsa04976	Bile secretion	18/2751	90/9376	0.681643038894947	ADCY1/SLC4A2/SCARB1/SLC2A1/ABCC3/ADCY3/ADCY9/SLC9A1/PRKACA/PRKACB/EPHX1/LDLR/NCEH1/ABCC4/ADCY2/ADCY6/GNAS/AQP8	-1.95550647185308
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/2751	44/9376	0.542216053666435	PTPRN/IL1B/PTPRN2/HLA-A/CPE/CD28/HLA-C	-1.9612706260112
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	55/2751	238/9376	0.787612755025675	C3/ACE/MAPK14/C2/C1R/NRP1/IFNAR1/EGFR/ADAR/C1S/MAVS/MAPK3/PIK3R2/STAT1/F13A1/EIF2AK2/MAPK1/RELA/MAP3K7/IRAK1/OAS2/TAB2/RPL26L1/PIK3CA/MASP1/PRKCA/TLR4/OAS3/C1QA/PIK3R1/TRAF6/OAS1/C1QB/MAPK9/IKBKG/RPL35/ISG15/PLCG2/RPL4/PLCG1/IL1B/MAPK12/TLR7/CHUK/C3AR1/MAPK11/RPS4Y1/C1QC/FGG/ACE2/CFD/MAPK10/FGB/CSF3/IL6	-2.13859883138501
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	28/2751	133/9376	0.717518988310471	PTPN11/SHC1/IFNAR1/HRAS/MAP2K2/MAPK3/MAP2K1/PIK3R2/FYN/ARAF/MAPK1/PPP3CB/SHC3/RAF1/SOS1/MICA/PIK3CA/PRKCA/PIK3R1/PLCG2/PPP3CC/PLCG1/RAC3/VAV2/SHC2/HLA-A/TNFRSF10A/HLA-C	-2.11420256805149
Human Diseases	Substance dependence	hsa05034	Alcoholism	42/2751	191/9376	0.749450461612246	GNG4/MAOB/CREB3L2/SHC1/GNAI1/GNG12/CALM3/HRAS/GNB2/GNB1/MAPK3/MAP2K1/MAOA/ARAF/MAPK1/ATF6B/PRKACA/GNB5/CAMKK2/PRKACB/ATF2/CREB3L1/HDAC4/SHC3/RAF1/SOS1/CREB3/HDAC7/HDAC2/ADORA2B/CAMKK1/GNAO1/CREB1/HDAC3/HDAC11/SLC29A1/HDAC10/SHC2/GNAS/HDAC9/CALM2/GRIN3B	-2.25428438271753
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	43/2751	195/9376	0.751555145448275	C3/MAPK14/SRC/AKT1/AKT3/AKT2/MAP2K2/MAPK3/MAP2K1/PIK3R2/VDAC1/CLCN3/MAPK1/RELA/VDAC3/MAP3K7/HDAC4/GSDMD/RAF1/PIK3CA/PRKCA/HDAC7/MTOR/HDAC2/TLR4/ACTG1/PIK3R1/HDAC3/HDAC11/PLCG2/ITGB3/PLCG1/ATG7/MAPK12/TLR7/HDAC10/MAPK11/CLCN5/FGG/ELANE/FGB/HDAC9/ITGA2B	-2.25912525561132
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	36/2751	168/9376	0.730331827387444	SMPD1/XIAP/IFNAR1/STAT6/CAPN1/STAT5B/PYGM/SHARPIN/STAT1/FADD/VDAC1/EIF2AK2/CHMP3/VDAC3/VPS4A/CHMP4A/PPID/TICAM2/CHMP2A/CAMK2D/TLR4/CHMP7/RNF31/MAPK9/AIFM1/PYGB/IL1B/PLA2G4D/PLA2G4C/SPATA2L/PPIA/PLA2G4B/ALOX15/MAPK10/TNFRSF10A/CAMK2A	-2.27268722023873
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/2751	38/9376	0.448449367694044	UNG/ADA/CD4/IKBKG/RFX5	-2.19527151606493
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	18/2751	99/9376	0.619675489904498	C3/C2/C1R/CFH/C1S/MASP1/KRT34/CFI/KRT23/C1QA/C1QB/C3AR1/C1QC/FCGR2B/FGG/CFD/IL10/KRT37	-2.45135452699015
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/2751	29/9376	0.352573985635318	CALM3/GNB1/CALM2	-2.25004402432114
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/2751	66/9376	0.516396241587081	MAF/SMAD2/STAT6/STAT1/RORA/RELA/TLR4/IL1B/IL6/IL10	-2.54053268564194
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	65/2751	298/9376	0.743402643090127	PRLR/TGFBR1/TNFRSF21/TGFBR2/INHBB/OSMR/TNFRSF8/IL15RA/INHA/IFNAR1/CSF1/IL1R1/BMPR2/CXCL12/LTBR/IL1R2/IL13RA1/RELL1/IL10RB/EPOR/GDF7/BMP8A/IL1RL1/IL17RC/CD4/CSF1R/IL15/TNFRSF11B/CXCL14/BMPR1A/CCL28/TNFRSF1B/TNFRSF10D/ACVR1B/CCL4/ACVR1/CCL3/BMP4/GHR/CCL8/CCL4L2/CCL13/IL1B/TNFRSF25/LEPR/ACVR2A/PRL/ACVR1C/CCR10/ACVR2B/CXCL1/CTF1/IL16/IL13RA2/CCL26/CCL23/IL11/THPO/TNFRSF6B/TNFRSF19/TNFRSF10A/CSF3/IL6/IL10/CXCL13	-2.90070266209131
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/2751	39/9376	0.34956053276664	HLA-A/CD28/HLA-C/IL10	-2.6228502867929
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/2751	45/9376	0.37869057716386	IL1B/HLA-A/CD28/IL6/HLA-C	-2.69208082376193
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	30/2751	160/9376	0.639040348964013	NLGN2/ITGB8/SDC3/GLG1/CD99L2/NRXN2/NFASC/SDC2/NLGN4X/NECTIN2/PTPRM/JAM3/ITGAV/CD4/SIGLEC1/NRCAM/VCAN/CNTNAP1/NEO1/NECTIN3/CLDN12/NLGN1/NECTIN1/CDH2/NEGR1/HLA-A/CD28/PTPRD/HLA-C/L1CAM	-2.96746365494246
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	4/2751	41/9376	0.33250879946095	GRIA3/GABRB3/GRIN3B/GABRA3	-2.76005860806832
NA	NA	hsa04082	Neuroactive ligand signaling	39/2751	199/9376	0.667941671278968	ADRA2C/ADCY1/GNG4/GNA11/GNAI1/GNG12/HTR2B/GNB2/OGFRL1/ADCY3/GNB1/ADCY9/PRKACA/GNB5/GNAQ/PRKACB/SLC1A2/PRKCA/OGFR/ADORA2B/GNAO1/P2RY14/GRIA3/SLC1A1/GABRB3/ADCY2/SLC17A9/HTR2A/GLRB/ADCY6/OPRL1/GABBR1/GNAS/P2RY1/GRIK2/ADRA2A/GRIN3B/GABRA3/P2RX6	-3.05090399903185
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/2751	54/9376	0.315575480969883	HLA-A/CD28/TG/HLA-C/IL10	-3.25016853931876
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/2751	82/9376	0.415635999326187	PSME3/CTSB/TAPBPL/HSPA2/CANX/CD4/CREB1/RFX5/HLA-A/HLA-C	-3.42473551820809
Organismal Systems	Sensory system	hsa04742	Taste transduction	10/2751	86/9376	0.396304092380783	PRKACA/PRKACB/SCN9A/CACNA1C/PDE1A/ADCY6/GABBR1/TAS2R1/P2RY1/GABRA3	-3.6240784693714
Human Diseases	Immune disease	hsa05310	Asthma	1/2751	32/9376	0.106506724827336	IL10	-3.26240485342256
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	28/2751	183/9376	0.52147554888138	IMP3/CSNK2B/FBL/FCF1/XPO1/GNL2/AK6/CSNK2A2/RRP7A/TBL3/NAT10/MDN1/EMG1/RPP25/SNU13/POP7/WDR75/WDR36/HEATR1/UTP4/RIOK2/UTP15/SBDS/REXO2/NOL6/RMRP/LSG1/NXT2	-4.21249153029922
NA	NA	hsa04382	Cornified envelope formation	34/2751	217/9376	0.534006067337055	PLEC/SPTLC2/PPP2R1A/PPP2CB/PPP2CA/KDSR/COL7A1/PPP2R5E/SPTLC1/CAPN1/ELOVL1/COL4A4/COL4A6/DST/COL4A5/S100A3/PPP2R1B/S100A16/KRT34/PPP2R5B/KRT23/PPP2R3A/TGM1/PPP2R5D/COL4A3/CLDN12/S100A13/SLC27A1/SLC27A4/ELOVL4/GBA2/KAZN/EPHX2/KRT37	-4.47531997312642
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	58/2751	323/9376	0.612001490029519	PDGFRB/TNXB/IRS1/ABL1/PDGFRA/MAPK7/NOTCH3/ZEB1/FSCN1/SHC1/ABCC1/CRK/BMI1/BMPR2/EGFR/IRS2/HRAS/VEGFA/MAP2K2/TIMP3/MAPK3/MAP2K1/DICER1/CRKL/PIK3R2/MAPK1/CYP1B1/CDKN1B/HDAC4/RAF1/SOS1/APC/RECK/BCL2L2/RPTOR/PIK3CA/PLAU/PRKCA/MTOR/WNT3/HDAC2/PRKCE/PIK3R1/BAK1/RASSF1/CDC25B/HOXD10/FZD3/PLCG2/MARCKS/ITGB3/CCND2/RHOA/PLCG1/EFNA5/EFNA4/EFNA3/SLC45A3	-4.57270359233584
Genetic Information Processing	Transcription	hsa03040	Spliceosome	35/2751	243/9376	0.490895192619818	PRPF8/SF3B3/NCBP2/DDX42/SF3B2/U2AF2/PRPF6/LSM3/SNRPA/WBP11/SF3B4/THOC2/CASC3/SART1/TXNL4A/SF3B5/CWC15/PRPF19/CRNKL1/SNRNP200/SNRPC/PRPF31/SNRPA1/SNU13/DHX16/EFTUD2/DHX38/SNRPD2/MAGOHB/PRPF4/XAB2/PPIL1/PCBP1/PRPF40B/GPKOW	-5.18133411132587
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/2751	143/9376	0.286004072263614	C3/C2/C1R/RO60/C1S/SSB/C1QA/C1QB/C1QC/CD28/ELANE/IL10	-5.54409071555741
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	50/2751	370/9376	0.460569620874964	ADRA2C/PRLR/CNR1/C3/LPAR1/EDNRB/PGRMC2/LYNX1/HTR2B/OGFRL1/F2R/NPW/BDKRB2/RXFP1/S1PR3/PTGIR/THRA/EDNRA/OGFR/ADORA2B/TBXA2R/F2RL3/CRHR1/P2RY14/GRIA3/S1PR2/GHR/GABRB3/GAL/LEPR/LYPD6/OXT/VIPR2/AVPR1A/BDKRB1/PRL/ADM/HTR2A/GLRB/C3AR1/OPRL1/GABBR1/P2RY1/GRIK2/MC1R/GRID1/ADRA2A/GRIN3B/GABRA3/P2RX6	-6.8219461009611
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	11/2751	449/9376	0.0834974769247708	CALM3/GRK3/ADCY3/GNB1/PRKACA/PRKACB/CAMK2D/ARRB1/PDE1A/CALM2/CAMK2A	-12.8245477846099