ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0035091 phosphatidylinositol binding 134/5871 284/18639 0.471830985915493 1.49794885819773 1.96308878343828e-08 2.69728398844419e-05 GO:0005543 phospholipid binding 210/5871 497/18639 0.422535211267606 1.34144673868453 2.05458185287028e-07 0.000112930806383969 GO:0051020 GTPase binding 142/5871 315/18639 0.450793650793651 1.43116042533518 2.46573813065435e-07 0.000112930806383969 GO:0031267 small GTPase binding 129/5871 283/18639 0.45583038869258 1.44715084565508 4.08755086399031e-07 0.000140407372178067 GO:0051539 4 iron, 4 sulfur cluster binding 30/5871 45/18639 0.666666666666667 2.11650485436893 1.30257064372691e-06 0.000357946412896156 GO:0140104 molecular carrier activity 113/5871 249/18639 0.453815261044177 1.44075330448006 2.70149600933956e-06 0.000618642586138759 GO:0031625 ubiquitin protein ligase binding 132/5871 302/18639 0.437086092715232 1.38764225551341 4.75013858050676e-06 0.000898624205970722 GO:0051536 iron-sulfur cluster binding 43/5871 76/18639 0.565789473684211 1.79624425140521 5.23216422690377e-06 0.000898624205970722 GO:0044389 ubiquitin-like protein ligase binding 139/5871 322/18639 0.43167701863354 1.37046975818609 5.99995997735143e-06 0.000915993889875652 GO:0051540 metal cluster binding 43/5871 77/18639 0.558441558441558 1.77291640398437 8.25247087660346e-06 0.00107832618801351 GO:0140098 catalytic activity, acting on RNA 162/5871 387/18639 0.418604651162791 1.32896816437119 9.22896265055704e-06 0.00107832618801351 GO:0032266 phosphatidylinositol-3-phosphate binding 30/5871 48/18639 0.625 1.98422330097087 9.41769596518348e-06 0.00107832618801351 GO:0043021 ribonucleoprotein complex binding 83/5871 177/18639 0.468926553672316 1.48872799078493 1.2276878812473e-05 0.00129757165294907 GO:0032977 membrane insertase activity 14/5871 17/18639 0.823529411764706 2.61450599657339 2.2504234295339e-05 0.00195317418637226 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 32/5871 54/18639 0.592592592592593 1.88133764832794 2.31473680034149e-05 0.00195317418637226 GO:0016757 glycosyltransferase activity 116/5871 267/18639 0.434456928838951 1.37929529835279 2.40971757945395e-05 0.00195317418637226 GO:0016755 aminoacyltransferase activity 199/5871 496/18639 0.401209677419355 1.27374334481679 2.41659106028591e-05 0.00195317418637226 GO:0019787 ubiquitin-like protein transferase activity 192/5871 479/18639 0.400835073068894 1.27255406692746 3.5536066048712e-05 0.00271258637505169 GO:0004842 ubiquitin-protein transferase activity 180/5871 449/18639 0.400890868596882 1.27273120418622 6.0852594349597e-05 0.00440060340191296 GO:0031418 L-ascorbic acid binding 15/5871 20/18639 0.75 2.38106796116505 8.01848448191441e-05 0.0055086988390752 GO:1901981 phosphatidylinositol phosphate binding 83/5871 185/18639 0.448648648648649 1.42435056415639 8.7829939905468e-05 0.00574658749667205 GO:0016758 hexosyltransferase activity 87/5871 197/18639 0.441624365482233 1.40205017002612 0.000119310392060207 0.0071793896829427 GO:0048029 monosaccharide binding 39/5871 74/18639 0.527027027027027 1.67318289162949 0.000120179012159885 0.0071793896829427 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 33/5871 60/18639 0.55 1.74611650485437 0.000135067782836326 0.00767907222716662 GO:0000287 magnesium ion binding 99/5871 230/18639 0.430434782608696 1.36652596032081 0.000139721110392406 0.00767907222716662 GO:0043022 ribosome binding 54/5871 112/18639 0.482142857142857 1.53068654646325 0.000157241463006004 0.00829333730935291 GO:0016853 isomerase activity 80/5871 180/18639 0.444444444444444 1.41100323624595 0.000170301817042005 0.00829333730935291 GO:0140597 protein carrier chaperone 83/5871 188/18639 0.441489361702128 1.40162156579219 0.000170839865782245 0.00829333730935291 GO:0015036 disulfide oxidoreductase activity 24/5871 40/18639 0.6 1.90485436893204 0.000184704839346564 0.00829333730935291 GO:0005525 GTP binding 152/5871 378/18639 0.402116402116402 1.2766219756511 0.000184751565508632 0.00829333730935291 GO:0000030 mannosyltransferase activity 17/5871 25/18639 0.68 2.15883495145631 0.000191092744970769 0.00829333730935291 GO:0046527 glucosyltransferase activity 14/5871 19/18639 0.736842105263158 2.33929483903935 0.000193149049417244 0.00829333730935291 GO:0019902 phosphatase binding 83/5871 190/18639 0.436842105263158 1.38686765457333 0.000260803451366938 0.0106710360377964 GO:0015035 protein-disulfide reductase activity 21/5871 34/18639 0.617647058823529 1.96087949743004 0.000264057660323929 0.0106710360377964 GO:0140142 nucleocytoplasmic carrier activity 20/5871 32/18639 0.625 1.98422330097087 0.000294534317483352 0.011562575777775 GO:0051117 ATPase binding 42/5871 84/18639 0.5 1.5873786407767 0.000306932511159346 0.0117145908425817 GO:0031543 peptidyl-proline dioxygenase activity 10/5871 12/18639 0.833333333333333 2.64563106796116 0.00032218593486953 0.0119644182300198 GO:0032182 ubiquitin-like protein binding 56/5871 120/18639 0.466666666666667 1.48155339805825 0.000348808081200895 0.0126121658834218 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 32/5871 60/18639 0.533333333333333 1.69320388349515 0.000360178082080551 0.012689350891761 GO:0016860 intramolecular oxidoreductase activity 29/5871 53/18639 0.547169811320755 1.73713134273676 0.000380890130546057 0.0130715578311096 GO:0050750 low-density lipoprotein particle receptor binding 17/5871 26/18639 0.653846153846154 2.07580283793876 0.000390053763519282 0.0130715578311096 GO:0005201 extracellular matrix structural constituent 74/5871 168/18639 0.44047619047619 1.39840499306519 0.000405392397274257 0.0132621227108293 GO:0005024 transforming growth factor beta receptor activity 12/5871 16/18639 0.75 2.38106796116505 0.000439548547469317 0.0140451094005312 GO:0061608 nuclear import signal receptor activity 14/5871 20/18639 0.7 2.22233009708738 0.000456732193479477 0.0142625007691091 GO:0050660 flavin adenine dinucleotide binding 42/5871 86/18639 0.488372093023256 1.55046285843305 0.000578077561000808 0.0172696436298353 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 73/5871 167/18639 0.437125748502994 1.38776815301436 0.000578168564026508 0.0172696436298353 GO:0070325 lipoprotein particle receptor binding 19/5871 31/18639 0.612903225806452 1.9458189790166 0.000594754879538038 0.0173870894571333 GO:0016417 S-acyltransferase activity 18/5871 29/18639 0.620689655172414 1.97053900234349 0.000667700627475459 0.019112930461485 GO:0003713 transcription coactivator activity 105/5871 256/18639 0.41015625 1.30214654126214 0.000762968404431966 0.0212906963087115 GO:0140101 catalytic activity, acting on a tRNA 62/5871 139/18639 0.446043165467626 1.41607878745547 0.000774770608031715 0.0212906963087115 GO:0030695 GTPase regulator activity 187/5871 489/18639 0.38241308793456 1.21406873548157 0.000796886730156451 0.021469066024215 GO:0061659 ubiquitin-like protein ligase activity 146/5871 372/18639 0.39247311827957 1.24600689007203 0.000841361285073435 0.0218887890554236 GO:0035252 UDP-xylosyltransferase activity 9/5871 11/18639 0.818181818181818 2.59752868490733 0.000860258085147652 0.0218887890554236 GO:0042285 xylosyltransferase activity 9/5871 11/18639 0.818181818181818 2.59752868490733 0.000860258085147652 0.0218887890554236 GO:0005178 integrin binding 70/5871 161/18639 0.434782608695652 1.3803292528493 0.000885624195675924 0.0218949235277784 GO:0060589 nucleoside-triphosphatase regulator activity 187/5871 490/18639 0.381632653061225 1.21159104418466 0.000892369517871607 0.0218949235277784 GO:0140318 protein transporter activity 23/5871 41/18639 0.560975609756098 1.78096140184703 0.000949773042072675 0.0228890253941847 GO:0051010 microtubule plus-end binding 14/5871 21/18639 0.666666666666667 2.11650485436893 0.000972925035587342 0.0228890253941847 GO:0031994 insulin-like growth factor I binding 10/5871 13/18639 0.769230769230769 2.44212098581031 0.000999520759571385 0.0228890253941847 GO:0070123 transforming growth factor beta receptor activity, type III 10/5871 13/18639 0.769230769230769 2.44212098581031 0.000999520759571385 0.0228890253941847 GO:0022884 macromolecule transmembrane transporter activity 19/5871 32/18639 0.59375 1.88501213592233 0.00103353877792565 0.0232274008646159 GO:0016829 lyase activity 84/5871 200/18639 0.42 1.33339805825243 0.0010641052898662 0.0232274008646159 GO:0008484 sulfuric ester hydrolase activity 12/5871 17/18639 0.705882352941177 2.24100513992005 0.00106501183003697 0.0232274008646159 GO:0019903 protein phosphatase binding 63/5871 144/18639 0.4375 1.38895631067961 0.00128872500732734 0.0274019513129849 GO:0019838 growth factor binding 60/5871 136/18639 0.441176470588235 1.40062821245003 0.00129630774042505 0.0274019513129849 GO:0008168 methyltransferase activity 85/5871 204/18639 0.416666666666667 1.32281553398058 0.00132680517535579 0.0276216713778615 GO:0061630 ubiquitin protein ligase activity 138/5871 353/18639 0.390934844192635 1.24112324321351 0.0013721022236034 0.0281383351527026 GO:0046332 SMAD binding 38/5871 79/18639 0.481012658227848 1.52709843922822 0.00147748462082916 0.0298538804267539 GO:0019001 guanyl nucleotide binding 154/5871 400/18639 0.385 1.22228155339806 0.00159545742092259 0.0313165499478234 GO:0032561 guanyl ribonucleotide binding 154/5871 400/18639 0.385 1.22228155339806 0.00159545742092259 0.0313165499478234 GO:0043130 ubiquitin binding 46/5871 100/18639 0.46 1.46038834951456 0.00163140534497213 0.0315711400562213 GO:0050431 transforming growth factor beta binding 15/5871 24/18639 0.625 1.98422330097087 0.00170563804299603 0.0325492593205076 GO:0016741 transferase activity, transferring one-carbon groups 88/5871 215/18639 0.409302325581395 1.29943553849627 0.00208308076372548 0.0385808552472385 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 13/5871 20/18639 0.65 2.06359223300971 0.00209739360133307 0.0385808552472385 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 93/5871 229/18639 0.406113537117904 1.28931190910247 0.00210594188030778 0.0385808552472385 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 12/5871 18/18639 0.666666666666667 2.11650485436893 0.00227959130486949 0.0390796323268885 GO:0070628 proteasome binding 12/5871 18/18639 0.666666666666667 2.11650485436893 0.00227959130486949 0.0390796323268885 GO:0016779 nucleotidyltransferase activity 59/5871 136/18639 0.433823529411765 1.37728440890919 0.00228515460367141 0.0390796323268885 GO:0004707 MAP kinase activity 11/5871 16/18639 0.6875 2.18264563106796 0.00242726232072145 0.0390796323268885 GO:0015923 mannosidase activity 11/5871 16/18639 0.6875 2.18264563106796 0.00242726232072145 0.0390796323268885 GO:0003995 acyl-CoA dehydrogenase activity 9/5871 12/18639 0.75 2.38106796116505 0.00247447453598202 0.0390796323268885 GO:0005025 transforming growth factor beta receptor activity, type I 9/5871 12/18639 0.75 2.38106796116505 0.00247447453598202 0.0390796323268885 GO:0005026 transforming growth factor beta receptor activity, type II 9/5871 12/18639 0.75 2.38106796116505 0.00247447453598202 0.0390796323268885 GO:0016361 activin receptor activity, type I 9/5871 12/18639 0.75 2.38106796116505 0.00247447453598202 0.0390796323268885 GO:0016362 activin receptor activity, type II 9/5871 12/18639 0.75 2.38106796116505 0.00247447453598202 0.0390796323268885 GO:0017002 activin receptor activity 9/5871 12/18639 0.75 2.38106796116505 0.00247447453598202 0.0390796323268885 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 9/5871 12/18639 0.75 2.38106796116505 0.00247447453598202 0.0390796323268885 GO:0008320 protein transmembrane transporter activity 16/5871 27/18639 0.592592592592593 1.88133764832794 0.00264122394467653 0.0412391102271085 GO:0008175 tRNA methyltransferase activity 19/5871 34/18639 0.558823529411765 1.77412906910337 0.00275783994637958 0.0425760908575904 GO:0003712 transcription coregulator activity 185/5871 495/18639 0.373737373737374 1.18652544866137 0.00281709729740082 0.0430076854069858 GO:0016776 phosphotransferase activity, phosphate group as acceptor 21/5871 39/18639 0.538461538461538 1.70948469006721 0.00309028887074945 0.0466599660264807 GO:0005158 insulin receptor binding 14/5871 23/18639 0.608695652173913 1.93246095398902 0.00345767871209443 0.0507375095268421 GO:0008171 O-methyltransferase activity 14/5871 23/18639 0.608695652173913 1.93246095398902 0.00345767871209443 0.0507375095268421 GO:0051287 NAD binding 27/5871 54/18639 0.5 1.5873786407767 0.00347112510591205 0.0507375095268421 GO:0019213 deacetylase activity 20/5871 37/18639 0.540540540540541 1.71608501705589 0.00363144003627779 0.0525220906299545 GO:0005085 guanyl-nucleotide exchange factor activity 92/5871 230/18639 0.4 1.26990291262136 0.00373464587256133 0.0534521190510341 GO:0051213 dioxygenase activity 42/5871 93/18639 0.451612903225806 1.4337613529596 0.00385778964020981 0.0543287106895141 GO:0008173 RNA methyltransferase activity 32/5871 67/18639 0.477611940298507 1.51630198521953 0.0038749735426291 0.0543287106895141 GO:0003756 protein disulfide isomerase activity 12/5871 19/18639 0.631578947368421 2.00510986203372 0.0044200957939688 0.0595762232679811 GO:0005520 insulin-like growth factor binding 12/5871 19/18639 0.631578947368421 2.00510986203372 0.0044200957939688 0.0595762232679811 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 12/5871 19/18639 0.631578947368421 2.00510986203372 0.0044200957939688 0.0595762232679811 GO:0003924 GTPase activity 127/5871 331/18639 0.38368580060423 1.21810928929692 0.00442268906356191 0.0595762232679811 GO:0016874 ligase activity 69/5871 167/18639 0.413173652694611 1.31172606243823 0.00453081329432101 0.0604401695766706 GO:0004177 aminopeptidase activity 21/5871 40/18639 0.525 1.66674757281553 0.00459538844134163 0.0607121511384943 GO:0048038 quinone binding 11/5871 17/18639 0.647058823529412 2.05425471159338 0.00492472155364298 0.064443499187671 GO:0070006 metalloaminopeptidase activity 15/5871 26/18639 0.576923076923077 1.83159073935773 0.00508956596878823 0.0659722985010851 GO:0032934 sterol binding 32/5871 68/18639 0.470588235294118 1.49400342661336 0.00513913291480859 0.0659922301396916 GO:0004559 alpha-mannosidase activity 10/5871 15/18639 0.666666666666667 2.11650485436893 0.00540308875571746 0.0687392958366277 GO:0048156 tau protein binding 22/5871 43/18639 0.511627906976744 1.62429442312034 0.00563468734432347 0.0710280771660592 GO:0032050 clathrin heavy chain binding 8/5871 11/18639 0.727272727272727 2.30891438658429 0.00598896762738588 0.0741337073876414 GO:0180030 inositol phosphate kinase activity 8/5871 11/18639 0.727272727272727 2.30891438658429 0.00598896762738588 0.0741337073876414 GO:0002020 protease binding 57/5871 136/18639 0.419117647058824 1.33059680182753 0.00653493234702816 0.0801696164715776 GO:0034062 5'-3' RNA polymerase activity 13/5871 22/18639 0.590909090909091 1.87599293909974 0.00684675531742863 0.0825214193521661 GO:0097747 RNA polymerase activity 13/5871 22/18639 0.590909090909091 1.87599293909974 0.00684675531742863 0.0825214193521661 GO:0061775 cohesin loader activity 63/5871 153/18639 0.411764705882353 1.30725299828669 0.0070529401184167 0.0842673019365612 GO:0005518 collagen binding 33/5871 72/18639 0.458333333333333 1.45509708737864 0.0074435776978408 0.0881678944554591 GO:0003925 G protein activity 26/5871 54/18639 0.481481481481481 1.52858683926645 0.00768929318248599 0.0897009136429727 GO:0016763 pentosyltransferase activity 24/5871 49/18639 0.489795918367347 1.55498315831187 0.00788400746022263 0.0897009136429727 GO:0001223 transcription coactivator binding 22/5871 44/18639 0.5 1.5873786407767 0.00796223896370587 0.0897009136429727 GO:0000510 H3-H4 histone complex chaperone activity 62/5871 151/18639 0.410596026490066 1.30354272487623 0.00802999445275519 0.0897009136429727 GO:0140584 chromatin extrusion motor activity 62/5871 151/18639 0.410596026490066 1.30354272487623 0.00802999445275519 0.0897009136429727 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 62/5871 151/18639 0.410596026490066 1.30354272487623 0.00802999445275519 0.0897009136429727 GO:0140849 ATP-dependent H2AZ histone chaperone activity 62/5871 151/18639 0.410596026490066 1.30354272487623 0.00802999445275519 0.0897009136429727 GO:0019199 transmembrane receptor protein kinase activity 35/5871 78/18639 0.448717948717949 1.42457057505601 0.00889821920474235 0.098598009575129 GO:0070064 proline-rich region binding 11/5871 18/18639 0.611111111111111 1.94012944983819 0.0090813548017156 0.0998222519804579 GO:0015616 DNA translocase activity 62/5871 152/18639 0.407894736842105 1.29496678589678 0.00946417080618618 0.102020833810565 GO:0140674 ATP-dependent histone chaperone activity 62/5871 152/18639 0.407894736842105 1.29496678589678 0.00946417080618618 0.102020833810565 GO:0019706 protein-cysteine S-palmitoyltransferase activity 14/5871 25/18639 0.56 1.7778640776699 0.00957837522675615 0.102020833810565 GO:0019707 protein-cysteine S-acyltransferase activity 14/5871 25/18639 0.56 1.7778640776699 0.00957837522675615 0.102020833810565 GO:0140658 ATP-dependent chromatin remodeler activity 64/5871 158/18639 0.40506329113924 1.28597763303429 0.0101122231610188 0.106878420178768 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 10/5871 16/18639 0.625 1.98422330097087 0.0103627994807108 0.108690736538143 GO:0001968 fibronectin binding 16/5871 30/18639 0.533333333333333 1.69320388349515 0.0105658675545143 0.109154150525583 GO:0016769 transferase activity, transferring nitrogenous groups 16/5871 30/18639 0.533333333333333 1.69320388349515 0.0105658675545143 0.109154150525583 GO:0140713 histone chaperone activity 66/5871 164/18639 0.402439024390244 1.27764622306417 0.0107505622488933 0.110233377089398 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 20/5871 40/18639 0.5 1.5873786407767 0.0111544431073747 0.113527443181725 GO:0004065 arylsulfatase activity 9/5871 14/18639 0.642857142857143 2.04091539528433 0.0117060333167735 0.114886355551763 GO:0004705 JUN kinase activity 9/5871 14/18639 0.642857142857143 2.04091539528433 0.0117060333167735 0.114886355551763 GO:0008174 mRNA methyltransferase activity 9/5871 14/18639 0.642857142857143 2.04091539528433 0.0117060333167735 0.114886355551763 GO:0008191 metalloendopeptidase inhibitor activity 9/5871 14/18639 0.642857142857143 2.04091539528433 0.0117060333167735 0.114886355551763 GO:0098821 BMP receptor activity 9/5871 14/18639 0.642857142857143 2.04091539528433 0.0117060333167735 0.114886355551763 GO:0051537 2 iron, 2 sulfur cluster binding 15/5871 28/18639 0.535714285714286 1.70076282940361 0.0125063556743253 0.121870444656191 GO:0035251 UDP-glucosyltransferase activity 8/5871 12/18639 0.666666666666667 2.11650485436893 0.0130179538101935 0.125962454473281 GO:0019200 carbohydrate kinase activity 12/5871 21/18639 0.571428571428571 1.81414701803051 0.0132101411659258 0.12692820952435 GO:0001094 TFIID-class transcription factor complex binding 7/5871 10/18639 0.7 2.22233009708738 0.0141085232898776 0.133690420691668 GO:0097177 mitochondrial ribosome binding 7/5871 10/18639 0.7 2.22233009708738 0.0141085232898776 0.133690420691668 GO:0003743 translation initiation factor activity 24/5871 51/18639 0.470588235294118 1.49400342661336 0.014283022029905 0.134416933349928 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 22/5871 46/18639 0.478260869565217 1.51836217813423 0.0149369262585822 0.138027363371656 GO:0008135 translation factor activity, RNA binding 36/5871 83/18639 0.433734939759036 1.37700315826412 0.0149596902394503 0.138027363371656 GO:0031593 polyubiquitin modification-dependent protein binding 27/5871 59/18639 0.457627118644068 1.45285502715156 0.0149680328547138 0.138027363371656 GO:0019003 GDP binding 33/5871 75/18639 0.44 1.3968932038835 0.0152056037209786 0.138648598896451 GO:0050840 extracellular matrix binding 30/5871 67/18639 0.447761194029851 1.42153311114331 0.0152372186560146 0.138648598896451 GO:0070273 phosphatidylinositol-4-phosphate binding 16/5871 31/18639 0.516129032258065 1.6385844033824 0.0155452964394486 0.140521298077647 GO:0016409 palmitoyltransferase activity 18/5871 36/18639 0.5 1.5873786407767 0.0156850872084058 0.140858234146075 GO:0015485 cholesterol binding 25/5871 54/18639 0.462962962962963 1.4697950377562 0.0159308612082763 0.14213638506605 GO:0015295 solute:proton symporter activity 13/5871 24/18639 0.541666666666667 1.71966019417476 0.0175658503881723 0.155712764086121 GO:0005096 GTPase activator activity 102/5871 271/18639 0.376383763837638 1.19492709490202 0.0177923197270744 0.155856956261849 GO:0038024 cargo receptor activity 29/5871 65/18639 0.446153846153846 1.41643017176998 0.017808982629629 0.155856956261849 GO:0032183 SUMO binding 10/5871 17/18639 0.588235294117647 1.8675042832667 0.0181314822336649 0.157675041702883 GO:0180051 translation factor activity 36/5871 84/18639 0.428571428571429 1.36061026352288 0.0183970940437019 0.158709459059798 GO:0004674 protein serine/threonine kinase activity 157/5871 433/18639 0.362586605080831 1.1511244646741 0.0184814508366577 0.158709459059798 GO:0019887 protein kinase regulator activity 96/5871 255/18639 0.376470588235294 1.19520274129069 0.0208140863785739 0.174650515542586 GO:0004407 histone deacetylase activity 12/5871 22/18639 0.545454545454545 1.73168578993822 0.0208462041841224 0.174650515542586 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 12/5871 22/18639 0.545454545454545 1.73168578993822 0.0208462041841224 0.174650515542586 GO:0033558 protein lysine deacetylase activity 12/5871 22/18639 0.545454545454545 1.73168578993822 0.0208462041841224 0.174650515542586 GO:0016887 ATP hydrolysis activity 151/5871 417/18639 0.3621103117506 1.14961234895579 0.0214877587049468 0.178934427033921 GO:0005044 scavenger receptor activity 14/5871 27/18639 0.518518518518518 1.64617044228695 0.0219933625971857 0.18078462243184 GO:0015605 organophosphate ester transmembrane transporter activity 23/5871 50/18639 0.46 1.46038834951456 0.0220811792688343 0.18078462243184 GO:0031369 translation initiation factor binding 16/5871 32/18639 0.5 1.5873786407767 0.022157312620851 0.18078462243184 GO:0003697 single-stranded DNA binding 49/5871 121/18639 0.40495867768595 1.28564551071171 0.0223213602325343 0.18078462243184 GO:0016407 acetyltransferase activity 40/5871 96/18639 0.416666666666667 1.32281553398058 0.0224510972503236 0.18078462243184 GO:0008408 3'-5' exonuclease activity 26/5871 58/18639 0.448275862068966 1.42316705724808 0.0224993962415172 0.18078462243184 GO:0009055 electron transfer activity 47/5871 116/18639 0.405172413793103 1.28632407097422 0.0245889417136259 0.196425615782104 GO:0043024 ribosomal small subunit binding 11/5871 20/18639 0.55 1.74611650485437 0.0247628976483559 0.19667179981989 GO:0000175 3'-5'-RNA exonuclease activity 17/5871 35/18639 0.485714285714286 1.54202496532594 0.0257973584769992 0.203701901632701 GO:0036121 double-stranded DNA helicase activity 22/5871 48/18639 0.458333333333333 1.45509708737864 0.0260133028024495 0.203701901632701 GO:0019211 phosphatase activator activity 13/5871 25/18639 0.52 1.65087378640777 0.0262189484797065 0.203701901632701 GO:0015215 nucleotide transmembrane transporter activity 15/5871 30/18639 0.5 1.5873786407767 0.026389329323596 0.203701901632701 GO:0051721 protein phosphatase 2A binding 15/5871 30/18639 0.5 1.5873786407767 0.026389329323596 0.203701901632701 GO:1901681 sulfur compound binding 102/5871 275/18639 0.370909090909091 1.17754633715799 0.0270134279237249 0.207354469090492 GO:0019207 kinase regulator activity 106/5871 287/18639 0.369337979094077 1.17255843848314 0.0277449307310405 0.209185927907275 GO:0004712 protein serine/threonine/tyrosine kinase activity 20/5871 43/18639 0.465116279069767 1.47663129374577 0.0277498040191821 0.209185927907275 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 7/5871 11/18639 0.636363636363636 2.02030008826125 0.0283177456992381 0.209185927907275 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 7/5871 11/18639 0.636363636363636 2.02030008826125 0.0283177456992381 0.209185927907275 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 7/5871 11/18639 0.636363636363636 2.02030008826125 0.0283177456992381 0.209185927907275 GO:0048185 activin binding 7/5871 11/18639 0.636363636363636 2.02030008826125 0.0283177456992381 0.209185927907275 GO:0097493 structural molecule activity conferring elasticity 7/5871 11/18639 0.636363636363636 2.02030008826125 0.0283177456992381 0.209185927907275 GO:0005048 signal sequence binding 23/5871 51/18639 0.450980392156863 1.43175328383781 0.0284868084293835 0.20930949081269 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 18/5871 38/18639 0.473684210526316 1.50383239652529 0.0293590072956216 0.211812829599102 GO:0042162 telomeric DNA binding 18/5871 38/18639 0.473684210526316 1.50383239652529 0.0293590072956216 0.211812829599102 GO:0043531 ADP binding 18/5871 38/18639 0.473684210526316 1.50383239652529 0.0293590072956216 0.211812829599102 GO:1990381 ubiquitin-specific protease binding 10/5871 18/18639 0.555555555555556 1.76375404530744 0.0294441415236015 0.211812829599102 GO:0000149 SNARE binding 43/5871 106/18639 0.405660377358491 1.28787323685657 0.0298819028534861 0.21384236729526 GO:0003689 DNA clamp loader activity 62/5871 160/18639 0.3875 1.23021844660194 0.030426528756829 0.216611660683332 GO:0071889 14-3-3 protein binding 16/5871 33/18639 0.484848484848485 1.53927625772286 0.0306870745733351 0.217340414761662 GO:0004527 exonuclease activity 35/5871 84/18639 0.416666666666667 1.32281553398058 0.0312406590265899 0.21845468545729 GO:0015399 primary active transmembrane transporter activity 64/5871 166/18639 0.385542168674699 1.22400280734589 0.0314706985390048 0.21845468545729 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 14/5871 28/18639 0.5 1.5873786407767 0.0314803695200462 0.21845468545729 GO:0097718 disordered domain specific binding 14/5871 28/18639 0.5 1.5873786407767 0.0314803695200462 0.21845468545729 GO:0015932 nucleobase-containing compound transmembrane transporter activity 25/5871 57/18639 0.43859649122807 1.39243740419009 0.0332301252998331 0.229438151567692 GO:0004386 helicase activity 60/5871 155/18639 0.387096774193548 1.2289383025368 0.0334791605233134 0.230001832795163 GO:0016835 carbon-oxygen lyase activity 33/5871 79/18639 0.417721518987342 1.32616443406661 0.0344144589248572 0.234874535123946 GO:0005484 SNAP receptor activity 17/5871 36/18639 0.472222222222222 1.49919093851133 0.0348451801383721 0.234874535123946 GO:0005159 insulin-like growth factor receptor binding 9/5871 16/18639 0.5625 1.78580097087379 0.0350431438867605 0.234874535123946 GO:0015562 efflux transmembrane transporter activity 9/5871 16/18639 0.5625 1.78580097087379 0.0350431438867605 0.234874535123946 GO:0034450 ubiquitin-ubiquitin ligase activity 9/5871 16/18639 0.5625 1.78580097087379 0.0350431438867605 0.234874535123946 GO:0017147 Wnt-protein binding 15/5871 31/18639 0.483870967741935 1.536172878171 0.0365556101524842 0.243822370628705 GO:0016798 hydrolase activity, acting on glycosyl bonds 51/5871 130/18639 0.392307692307692 1.24548170276326 0.0369236702448983 0.245087550321209 GO:0010314 phosphatidylinositol-5-phosphate binding 11/5871 21/18639 0.523809523809524 1.6629680998613 0.0374709297790289 0.245330570186638 GO:0072542 protein phosphatase activator activity 11/5871 21/18639 0.523809523809524 1.6629680998613 0.0374709297790289 0.245330570186638 GO:0015216 purine nucleotide transmembrane transporter activity 13/5871 26/18639 0.5 1.5873786407767 0.0376225775983611 0.245330570186638 GO:1901682 sulfur compound transmembrane transporter activity 27/5871 63/18639 0.428571428571429 1.36061026352288 0.0376744907637413 0.245330570186638 GO:0003684 damaged DNA binding 31/5871 74/18639 0.418918918918919 1.32996588821832 0.0379247774132991 0.245795491348457 GO:0061749 forked DNA-dependent helicase activity 21/5871 47/18639 0.446808510638298 1.41850857260897 0.0393637591795446 0.251569252364396 GO:1990518 single-stranded 3'-5' DNA helicase activity 21/5871 47/18639 0.446808510638298 1.41850857260897 0.0393637591795446 0.251569252364396 GO:0016791 phosphatase activity 100/5871 273/18639 0.366300366300366 1.16291475514776 0.0393649121239775 0.251569252364396 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 48/5871 122/18639 0.39344262295082 1.24908483208658 0.0398616599638143 0.253564448103152 GO:0008194 UDP-glycosyltransferase activity 56/5871 145/18639 0.386206896551724 1.22611315701373 0.0405796309000649 0.256941994731287 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 25/5871 58/18639 0.431034482758621 1.36842986273853 0.041359465495527 0.258336088551018 GO:0005545 1-phosphatidylinositol binding 8/5871 14/18639 0.571428571428571 1.81414701803051 0.0417398920366274 0.258336088551018 GO:0042813 Wnt receptor activity 8/5871 14/18639 0.571428571428571 1.81414701803051 0.0417398920366274 0.258336088551018 GO:0046030 inositol trisphosphate phosphatase activity 8/5871 14/18639 0.571428571428571 1.81414701803051 0.0417398920366274 0.258336088551018 GO:0098847 sequence-specific single stranded DNA binding 8/5871 14/18639 0.571428571428571 1.81414701803051 0.0417398920366274 0.258336088551018 GO:1902936 phosphatidylinositol bisphosphate binding 44/5871 111/18639 0.396396396396396 1.25846234584099 0.0420065897734316 0.258820871518811 GO:0051861 glycolipid binding 14/5871 29/18639 0.482758620689655 1.53264144626716 0.0436162891956378 0.267370184540942 GO:0016836 hydro-lyase activity 26/5871 61/18639 0.426229508196721 1.35317523476046 0.043783327162818 0.267370184540942 GO:0019208 phosphatase regulator activity 46/5871 117/18639 0.393162393162393 1.24819517052527 0.0440089064730167 0.267558572981969 GO:0005346 purine ribonucleotide transmembrane transporter activity 10/5871 19/18639 0.526315789473684 1.6709248850281 0.0449480921749726 0.271534679409951 GO:0001091 RNA polymerase II general transcription initiation factor binding 12/5871 24/18639 0.5 1.5873786407767 0.0450581564086382 0.271534679409951 GO:0140296 general transcription initiation factor binding 23/5871 53/18639 0.433962264150943 1.37772485803261 0.045380071258327 0.272280427549962 GO:0003725 double-stranded RNA binding 31/5871 75/18639 0.413333333333333 1.31223300970874 0.04563647215346 0.272628316255887 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 51/5871 132/18639 0.386363636363636 1.2266107678729 0.0484652087234188 0.287197448855811 GO:0001221 transcription coregulator binding 45/5871 115/18639 0.391304347826087 1.24229632756437 0.0496589175356464 0.287197448855811 GO:0000995 RNA polymerase III general transcription initiation factor activity 7/5871 12/18639 0.583333333333333 1.85194174757282 0.0497374543439006 0.287197448855811 GO:0016423 tRNA (guanine) methyltransferase activity 7/5871 12/18639 0.583333333333333 1.85194174757282 0.0497374543439006 0.287197448855811 GO:0035497 cAMP response element binding 7/5871 12/18639 0.583333333333333 1.85194174757282 0.0497374543439006 0.287197448855811 GO:0141221 histone deacetylase activity, hydrolytic mechanism 7/5871 12/18639 0.583333333333333 1.85194174757282 0.0497374543439006 0.287197448855811 GO:0009378 four-way junction helicase activity 21/5871 48/18639 0.4375 1.38895631067961 0.0497474474728407 0.287197448855811 GO:0043138 3'-5' DNA helicase activity 21/5871 48/18639 0.4375 1.38895631067961 0.0497474474728407 0.287197448855811 GO:0004532 RNA exonuclease activity 18/5871 40/18639 0.45 1.42864077669903 0.0503570002036071 0.289500076484335 GO:0004540 RNA nuclease activity 47/5871 121/18639 0.388429752066116 1.23317018374388 0.0516293291930809 0.295577909630388 GO:0015078 proton transmembrane transporter activity 69/5871 185/18639 0.372972972972973 1.18409866176856 0.0533751092198129 0.304304564597606 GO:0004550 nucleoside diphosphate kinase activity 9/5871 17/18639 0.529411764705882 1.68075385494003 0.0540687632464931 0.304469183199514 GO:0004659 prenyltransferase activity 9/5871 17/18639 0.529411764705882 1.68075385494003 0.0540687632464931 0.304469183199514 GO:0017110 nucleoside diphosphate phosphatase activity 9/5871 17/18639 0.529411764705882 1.68075385494003 0.0540687632464931 0.304469183199514 GO:0008375 acetylglucosaminyltransferase activity 19/5871 43/18639 0.441860465116279 1.40279972905848 0.0544584913398757 0.305412110616282 GO:0019843 rRNA binding 27/5871 65/18639 0.415384615384615 1.31874533233757 0.0558408117325974 0.30832392226318 GO:0030295 protein kinase activator activity 53/5871 139/18639 0.381294964028777 1.21051896347 0.0567408355981324 0.30832392226318 GO:0045296 cadherin binding 119/5871 334/18639 0.356287425149701 1.13112609731992 0.0581274043995756 0.30832392226318 GO:0031210 phosphatidylcholine binding 14/5871 30/18639 0.466666666666667 1.48155339805825 0.0586898790836745 0.30832392226318 GO:0070566 adenylyltransferase activity 14/5871 30/18639 0.466666666666667 1.48155339805825 0.0586898790836745 0.30832392226318 GO:0019209 kinase activator activity 56/5871 148/18639 0.378378378378378 1.20125951193912 0.0588980377264075 0.30832392226318 GO:0004445 inositol-polyphosphate 5-phosphatase activity 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0008239 dipeptidyl-peptidase activity 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0008641 ubiquitin-like modifier activating enzyme activity 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0015924 mannosyl-oligosaccharide mannosidase activity 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0016783 sulfurtransferase activity 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0043295 glutathione binding 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:1905394 retromer complex binding 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 6/5871 10/18639 0.6 1.90485436893204 0.059241277640087 0.30832392226318 GO:0005109 frizzled binding 17/5871 38/18639 0.447368421052632 1.42028615227389 0.0594827681556004 0.308412541304887 GO:0140297 DNA-binding transcription factor binding 170/5871 488/18639 0.348360655737705 1.10596052841 0.0603998606590282 0.311990257689868 GO:0003714 transcription corepressor activity 75/5871 204/18639 0.367647058823529 1.16719017704169 0.0616626050366415 0.316282318134126 GO:0031072 heat shock protein binding 50/5871 131/18639 0.381679389312977 1.21173942044023 0.0616911654002516 0.316282318134126 GO:0003707 nuclear steroid receptor activity 12/5871 25/18639 0.48 1.52388349514563 0.0624481944968827 0.317791923106359 GO:0008483 transaminase activity 12/5871 25/18639 0.48 1.52388349514563 0.0624481944968827 0.317791923106359 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 36/5871 91/18639 0.395604395604396 1.25594793555959 0.0629542836055306 0.319185186988926 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 15/5871 33/18639 0.454545454545455 1.44307149161518 0.0647374201225543 0.322540342617792 GO:0016004 phospholipase activator activity 10/5871 20/18639 0.5 1.5873786407767 0.0651332867015894 0.322540342617792 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 10/5871 20/18639 0.5 1.5873786407767 0.0651332867015894 0.322540342617792 GO:0015929 hexosaminidase activity 8/5871 15/18639 0.533333333333333 1.69320388349515 0.0652592541832213 0.322540342617792 GO:0050780 dopamine receptor binding 8/5871 15/18639 0.533333333333333 1.69320388349515 0.0652592541832213 0.322540342617792 GO:0141050 histone H3K deacetylase activity 8/5871 15/18639 0.533333333333333 1.69320388349515 0.0652592541832213 0.322540342617792 GO:0141051 histone H4K deacetylase activity 8/5871 15/18639 0.533333333333333 1.69320388349515 0.0652592541832213 0.322540342617792 GO:0008017 microtubule binding 99/5871 276/18639 0.358695652173913 1.13877163360068 0.0667158899310429 0.328557823531372 GO:0003954 NADH dehydrogenase activity 19/5871 44/18639 0.431818181818182 1.37091791703442 0.0683692994987989 0.335497919683392 GO:0008080 N-acetyltransferase activity 28/5871 69/18639 0.405797101449275 1.28830730265935 0.0693101676597106 0.338904520869902 GO:0044390 ubiquitin-like protein conjugating enzyme binding 16/5871 36/18639 0.444444444444444 1.41100323624595 0.0703073869785977 0.342561523789338 GO:0015631 tubulin binding 135/5871 385/18639 0.350649350649351 1.113226579246 0.0721537225120089 0.350315246401061 GO:0019905 syntaxin binding 25/5871 61/18639 0.409836065573771 1.30113003342352 0.0743877592004048 0.358906900721117 GO:0008276 protein methyltransferase activity 37/5871 95/18639 0.389473684210526 1.2364844149208 0.074445754516389 0.358906900721117 GO:0000295 adenine nucleotide transmembrane transporter activity 11/5871 23/18639 0.478260869565217 1.51836217813423 0.074980669684838 0.358966690407552 GO:0140103 catalytic activity, acting on a glycoprotein 11/5871 23/18639 0.478260869565217 1.51836217813423 0.074980669684838 0.358966690407552 GO:0042626 ATPase-coupled transmembrane transporter activity 38/5871 98/18639 0.387755102040816 1.23102833366356 0.0758409088443504 0.361824335944922 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 9/5871 18/18639 0.5 1.5873786407767 0.0786933849693848 0.369627106239675 GO:0002161 aminoacyl-tRNA editing activity 7/5871 13/18639 0.538461538461538 1.70948469006721 0.0790905161822886 0.369627106239675 GO:0009982 pseudouridine synthase activity 7/5871 13/18639 0.538461538461538 1.70948469006721 0.0790905161822886 0.369627106239675 GO:0017154 semaphorin receptor activity 7/5871 13/18639 0.538461538461538 1.70948469006721 0.0790905161822886 0.369627106239675 GO:0019104 DNA N-glycosylase activity 7/5871 13/18639 0.538461538461538 1.70948469006721 0.0790905161822886 0.369627106239675 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 7/5871 13/18639 0.538461538461538 1.70948469006721 0.0790905161822886 0.369627106239675 GO:0034212 protein N-acetyltransferase activity 22/5871 53/18639 0.415094339622642 1.31782377724858 0.0795317975754685 0.36962834787878 GO:0019888 protein phosphatase regulator activity 41/5871 107/18639 0.383177570093458 1.21649578078214 0.0796288143901884 0.36962834787878 GO:0005506 iron ion binding 57/5871 154/18639 0.37012987012987 1.17507250031522 0.0832473751775462 0.38379869858955 GO:0042578 phosphoric ester hydrolase activity 127/5871 363/18639 0.349862258953168 1.11072775415229 0.0835038544853318 0.38379869858955 GO:0097602 cullin family protein binding 12/5871 26/18639 0.461538461538462 1.46527259148618 0.0837272946956157 0.38379869858955 GO:0051219 phosphoprotein binding 36/5871 93/18639 0.387096774193548 1.2289383025368 0.0840678430191122 0.38379869858955 GO:0043539 protein serine/threonine kinase activator activity 29/5871 73/18639 0.397260273972603 1.26120494746642 0.0840781719617573 0.38379869858955 GO:0046915 transition metal ion transmembrane transporter activity 19/5871 45/18639 0.422222222222222 1.34045307443366 0.084502004419979 0.384456139314739 GO:0009975 cyclase activity 10/5871 21/18639 0.476190476190476 1.51178918169209 0.090280883903917 0.408045837118362 GO:0140312 cargo adaptor activity 10/5871 21/18639 0.476190476190476 1.51178918169209 0.090280883903917 0.408045837118362 GO:0160215 deacylase activity 26/5871 65/18639 0.4 1.26990291262136 0.0911735597688114 0.410729413515891 GO:0016830 carbon-carbon lyase activity 21/5871 51/18639 0.411764705882353 1.30725299828669 0.0922072764850632 0.414028751276068 GO:0016651 oxidoreductase activity, acting on NAD(P)H 34/5871 88/18639 0.386363636363636 1.2266107678729 0.0932831018295003 0.417495055093594 GO:0030145 manganese ion binding 27/5871 68/18639 0.397058823529412 1.26056539120503 0.0936143493362301 0.417615883096374 GO:0008142 oxysterol binding 8/5871 16/18639 0.5 1.5873786407767 0.0954753644796822 0.417615883096374 GO:0016722 oxidoreductase activity, acting on metal ions 8/5871 16/18639 0.5 1.5873786407767 0.0954753644796822 0.417615883096374 GO:0097027 ubiquitin-protein transferase activator activity 8/5871 16/18639 0.5 1.5873786407767 0.0954753644796822 0.417615883096374 GO:0000099 sulfur amino acid transmembrane transporter activity 6/5871 11/18639 0.545454545454545 1.73168578993822 0.0963495159691053 0.417615883096374 GO:0010854 adenylate cyclase regulator activity 6/5871 11/18639 0.545454545454545 1.73168578993822 0.0963495159691053 0.417615883096374 GO:0034511 U3 snoRNA binding 6/5871 11/18639 0.545454545454545 1.73168578993822 0.0963495159691053 0.417615883096374 GO:0048407 platelet-derived growth factor binding 6/5871 11/18639 0.545454545454545 1.73168578993822 0.0963495159691053 0.417615883096374 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 6/5871 11/18639 0.545454545454545 1.73168578993822 0.0963495159691053 0.417615883096374 GO:1900750 oligopeptide binding 6/5871 11/18639 0.545454545454545 1.73168578993822 0.0963495159691053 0.417615883096374 GO:0003724 RNA helicase activity 30/5871 77/18639 0.38961038961039 1.23691842138444 0.100018389654753 0.432154928885629 GO:0001098 basal transcription machinery binding 24/5871 60/18639 0.4 1.26990291262136 0.101700044097981 0.436095399288031 GO:0001099 basal RNA polymerase II transcription machinery binding 24/5871 60/18639 0.4 1.26990291262136 0.101700044097981 0.436095399288031 GO:0000049 tRNA binding 31/5871 80/18639 0.3875 1.23021844660194 0.101882549615326 0.436095399288031 GO:0030276 clathrin binding 19/5871 46/18639 0.41304347826087 1.31131279020684 0.102927565183817 0.439200231560758 GO:0140097 catalytic activity, acting on DNA 117/5871 336/18639 0.348214285714286 1.10549583911234 0.103805801204085 0.441576380354217 GO:0008235 metalloexopeptidase activity 26/5871 66/18639 0.393939393939394 1.25066195939982 0.106912649751553 0.452840480427848 GO:0043178 alcohol binding 35/5871 92/18639 0.380434782608696 1.20778809624314 0.108220738850026 0.452840480427848 GO:0005385 zinc ion transmembrane transporter activity 12/5871 27/18639 0.444444444444444 1.41100323624595 0.109000794372546 0.452840480427848 GO:0008266 poly(U) RNA binding 12/5871 27/18639 0.444444444444444 1.41100323624595 0.109000794372546 0.452840480427848 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 12/5871 27/18639 0.444444444444444 1.41100323624595 0.109000794372546 0.452840480427848 GO:0042577 lipid phosphatase activity 9/5871 19/18639 0.473684210526316 1.50383239652529 0.109064148484356 0.452840480427848 GO:0050145 nucleoside monophosphate kinase activity 9/5871 19/18639 0.473684210526316 1.50383239652529 0.109064148484356 0.452840480427848 GO:0106310 protein serine kinase activity 125/5871 361/18639 0.346260387811634 1.09929268751849 0.109090392301032 0.452840480427848 GO:0140767 enzyme-substrate adaptor activity 51/5871 139/18639 0.366906474820144 1.16483900258434 0.110070513469572 0.455512422722852 GO:0005080 protein kinase C binding 21/5871 52/18639 0.403846153846154 1.28211351755041 0.110397115550735 0.455512422722852 GO:0008170 N-methyltransferase activity 37/5871 98/18639 0.377551020408163 1.19863285119873 0.110817746119544 0.455878991521717 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 17/5871 41/18639 0.414634146341463 1.31636277527824 0.115139169098383 0.461676402855253 GO:0008137 NADH dehydrogenase (ubiquinone) activity 17/5871 41/18639 0.414634146341463 1.31636277527824 0.115139169098383 0.461676402855253 GO:0016877 ligase activity, forming carbon-sulfur bonds 17/5871 41/18639 0.414634146341463 1.31636277527824 0.115139169098383 0.461676402855253 GO:0033218 amide binding 87/5871 247/18639 0.352226720647773 1.11823434613419 0.115795236750935 0.461676402855253 GO:0005161 platelet-derived growth factor receptor binding 7/5871 14/18639 0.5 1.5873786407767 0.11644114032795 0.461676402855253 GO:0008474 palmitoyl-(protein) hydrolase activity 7/5871 14/18639 0.5 1.5873786407767 0.11644114032795 0.461676402855253 GO:0008559 ABC-type xenobiotic transporter activity 7/5871 14/18639 0.5 1.5873786407767 0.11644114032795 0.461676402855253 GO:0016530 metallochaperone activity 7/5871 14/18639 0.5 1.5873786407767 0.11644114032795 0.461676402855253 GO:0030983 mismatched DNA binding 7/5871 14/18639 0.5 1.5873786407767 0.11644114032795 0.461676402855253 GO:0071933 Arp2/3 complex binding 7/5871 14/18639 0.5 1.5873786407767 0.11644114032795 0.461676402855253 GO:0098599 palmitoyl hydrolase activity 7/5871 14/18639 0.5 1.5873786407767 0.11644114032795 0.461676402855253 GO:0008187 poly-pyrimidine tract binding 13/5871 30/18639 0.433333333333333 1.37572815533981 0.116595132307695 0.461676402855253 GO:0031624 ubiquitin conjugating enzyme binding 13/5871 30/18639 0.433333333333333 1.37572815533981 0.116595132307695 0.461676402855253 GO:0030971 receptor tyrosine kinase binding 31/5871 81/18639 0.382716049382716 1.21503056454513 0.116997372753406 0.461937902767756 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 45/5871 122/18639 0.368852459016393 1.17101703008117 0.118370410642466 0.465614562958087 GO:0004860 protein kinase inhibitor activity 32/5871 84/18639 0.380952380952381 1.20943134535368 0.118607920419439 0.465614562958087 GO:0015026 coreceptor activity 24/5871 61/18639 0.39344262295082 1.24908483208658 0.119416120788301 0.465614562958087 GO:0016790 thiolester hydrolase activity 18/5871 44/18639 0.409090909090909 1.29876434245366 0.119622955403351 0.465614562958087 GO:0030020 extracellular matrix structural constituent conferring tensile strength 18/5871 44/18639 0.409090909090909 1.29876434245366 0.119622955403351 0.465614562958087 GO:0050321 tau-protein kinase activity 10/5871 22/18639 0.454545454545455 1.44307149161518 0.120435241012235 0.467452037149184 GO:0043495 protein-membrane adaptor activity 19/5871 47/18639 0.404255319148936 1.28341251807478 0.123670708159734 0.475976338967717 GO:0061733 protein-lysine-acetyltransferase activity 19/5871 47/18639 0.404255319148936 1.28341251807478 0.123670708159734 0.475976338967717 GO:0140359 ABC-type transporter activity 19/5871 47/18639 0.404255319148936 1.28341251807478 0.123670708159734 0.475976338967717 GO:0042054 histone methyltransferase activity 26/5871 67/18639 0.388059701492537 1.23199536299087 0.124275371486121 0.476967487212094 GO:0140030 modification-dependent protein binding 62/5871 173/18639 0.358381502890173 1.13777428587463 0.125174767008058 0.479081141696579 GO:0004518 nuclease activity 74/5871 209/18639 0.354066985645933 1.12407674083709 0.12593507292573 0.480652194999869 GO:0097110 scaffold protein binding 27/5871 70/18639 0.385714285714286 1.2245492371706 0.126419770320332 0.481165552410351 GO:0004521 RNA endonuclease activity 28/5871 73/18639 0.383561643835616 1.21771512169171 0.12839586694779 0.486076046555504 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 15/5871 36/18639 0.416666666666667 1.32281553398058 0.129125005089344 0.486076046555504 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 15/5871 36/18639 0.416666666666667 1.32281553398058 0.129125005089344 0.486076046555504 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 15/5871 36/18639 0.416666666666667 1.32281553398058 0.129125005089344 0.486076046555504 GO:0004709 MAP kinase kinase kinase activity 11/5871 25/18639 0.44 1.3968932038835 0.130040203216885 0.486853512861036 GO:0008139 nuclear localization sequence binding 11/5871 25/18639 0.44 1.3968932038835 0.130040203216885 0.486853512861036 GO:0008186 ATP-dependent activity, acting on RNA 30/5871 79/18639 0.379746835443038 1.20560403096964 0.131898386225026 0.488587131992523 GO:0004029 aldehyde dehydrogenase (NAD+) activity 8/5871 17/18639 0.470588235294118 1.49400342661336 0.132281232242517 0.488587131992523 GO:0008429 phosphatidylethanolamine binding 8/5871 17/18639 0.470588235294118 1.49400342661336 0.132281232242517 0.488587131992523 GO:0051787 misfolded protein binding 8/5871 17/18639 0.470588235294118 1.49400342661336 0.132281232242517 0.488587131992523 GO:0070403 NAD+ binding 8/5871 17/18639 0.470588235294118 1.49400342661336 0.132281232242517 0.488587131992523 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 16/5871 39/18639 0.41025641025641 1.3024645257655 0.134317606872771 0.494778530410688 GO:0004879 nuclear receptor activity 23/5871 59/18639 0.389830508474576 1.23761724535132 0.136408316403868 0.501136435130787 GO:0016866 intramolecular transferase activity 12/5871 28/18639 0.428571428571429 1.36061026352288 0.138224042200753 0.503411124893662 GO:0016410 N-acyltransferase activity 35/5871 94/18639 0.372340425531915 1.18209047717414 0.138540502115476 0.503411124893662 GO:0004402 histone acetyltransferase activity 17/5871 42/18639 0.404761904761905 1.28502080443828 0.138928773942092 0.503411124893662 GO:0016859 cis-trans isomerase activity 17/5871 42/18639 0.404761904761905 1.28502080443828 0.138928773942092 0.503411124893662 GO:0120013 lipid transfer activity 25/5871 65/18639 0.384615384615385 1.22106049290515 0.14118003553676 0.503411124893662 GO:0008013 beta-catenin binding 39/5871 106/18639 0.367924528301887 1.16807107528851 0.142213822628493 0.503411124893662 GO:0004300 enoyl-CoA hydratase activity 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:0005049 nuclear export signal receptor activity 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:0005078 MAP-kinase scaffold activity 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:0005095 GTPase inhibitor activity 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:0008603 cAMP-dependent protein kinase regulator activity 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:0034452 dynactin binding 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:0035014 phosphatidylinositol 3-kinase regulator activity 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:0043047 single-stranded telomeric DNA binding 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:1990459 transferrin receptor binding 6/5871 12/18639 0.5 1.5873786407767 0.14296157759431 0.503411124893662 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 26/5871 68/18639 0.382352941176471 1.21387778412336 0.143256004245576 0.503411124893662 GO:0022853 active monoatomic ion transmembrane transporter activity 43/5871 118/18639 0.364406779661017 1.15690307717624 0.144822919040677 0.506973068933204 GO:0052745 inositol phosphate phosphatase activity 9/5871 20/18639 0.45 1.42864077669903 0.145007580852074 0.506973068933204 GO:0004519 endonuclease activity 46/5871 127/18639 0.362204724409449 1.14991208623194 0.146234151642468 0.509963767402923 GO:0016879 ligase activity, forming carbon-nitrogen bonds 19/5871 48/18639 0.395833333333333 1.25667475728155 0.146707274037382 0.510318467157882 GO:0052866 phosphatidylinositol phosphate phosphatase activity 14/5871 34/18639 0.411764705882353 1.30725299828669 0.151324295904093 0.525049450939957 GO:0050661 NADP binding 21/5871 54/18639 0.388888888888889 1.23462783171521 0.152944484823235 0.529334312713161 GO:0016849 phosphorus-oxygen lyase activity 10/5871 23/18639 0.434782608695652 1.3803292528493 0.155400295879464 0.532839517899574 GO:0042171 lysophosphatidic acid acyltransferase activity 10/5871 23/18639 0.434782608695652 1.3803292528493 0.155400295879464 0.532839517899574 GO:0071617 lysophospholipid acyltransferase activity 10/5871 23/18639 0.434782608695652 1.3803292528493 0.155400295879464 0.532839517899574 GO:0005539 glycosaminoglycan binding 84/5871 242/18639 0.347107438016529 1.10198186632432 0.155508476475786 0.532839517899574 GO:0004714 transmembrane receptor protein tyrosine kinase activity 23/5871 60/18639 0.383333333333333 1.21699029126214 0.157983728918339 0.537301097855934 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 23/5871 60/18639 0.383333333333333 1.21699029126214 0.157983728918339 0.537301097855934 GO:0098531 ligand-modulated transcription factor activity 23/5871 60/18639 0.383333333333333 1.21699029126214 0.157983728918339 0.537301097855934 GO:0050997 quaternary ammonium group binding 16/5871 40/18639 0.4 1.26990291262136 0.161216013038658 0.541622370239859 GO:0071949 FAD binding 16/5871 40/18639 0.4 1.26990291262136 0.161216013038658 0.541622370239859 GO:0000774 adenyl-nucleotide exchange factor activity 7/5871 15/18639 0.466666666666667 1.48155339805825 0.161225290704587 0.541622370239859 GO:0016846 carbon-sulfur lyase activity 7/5871 15/18639 0.466666666666667 1.48155339805825 0.161225290704587 0.541622370239859 GO:0031005 filamin binding 7/5871 15/18639 0.466666666666667 1.48155339805825 0.161225290704587 0.541622370239859 GO:0016279 protein-lysine N-methyltransferase activity 26/5871 69/18639 0.376811594202899 1.1962853524694 0.163824748223477 0.545617738125984 GO:0008198 ferrous iron binding 11/5871 26/18639 0.423076923076923 1.34316654219567 0.164003002799149 0.545617738125984 GO:0034237 protein kinase A regulatory subunit binding 11/5871 26/18639 0.423076923076923 1.34316654219567 0.164003002799149 0.545617738125984 GO:0043548 phosphatidylinositol 3-kinase binding 11/5871 26/18639 0.423076923076923 1.34316654219567 0.164003002799149 0.545617738125984 GO:0030291 protein serine/threonine kinase inhibitor activity 18/5871 46/18639 0.391304347826087 1.24229632756437 0.168821509716746 0.547395585654587 GO:0008094 ATP-dependent activity, acting on DNA 73/5871 210/18639 0.347619047619048 1.10360610263523 0.17102016897763 0.547395585654587 GO:0019210 kinase inhibitor activity 33/5871 90/18639 0.366666666666667 1.16407766990291 0.172075448558238 0.547395585654587 GO:0008238 exopeptidase activity 37/5871 102/18639 0.362745098039216 1.1516276413478 0.174592844765245 0.547395585654587 GO:0016854 racemase and epimerase activity 8/5871 18/18639 0.444444444444444 1.41100323624595 0.175151510061023 0.547395585654587 GO:0034185 apolipoprotein binding 8/5871 18/18639 0.444444444444444 1.41100323624595 0.175151510061023 0.547395585654587 GO:0035615 clathrin adaptor activity 8/5871 18/18639 0.444444444444444 1.41100323624595 0.175151510061023 0.547395585654587 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 8/5871 18/18639 0.444444444444444 1.41100323624595 0.175151510061023 0.547395585654587 GO:1901611 phosphatidylglycerol binding 8/5871 18/18639 0.444444444444444 1.41100323624595 0.175151510061023 0.547395585654587 GO:0005496 steroid binding 39/5871 108/18639 0.361111111111111 1.14644012944984 0.175440874129527 0.547395585654587 GO:1990782 protein tyrosine kinase binding 42/5871 117/18639 0.358974358974359 1.13965646004481 0.176306144439746 0.547395585654587 GO:0000182 rDNA binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0004862 cAMP-dependent protein kinase inhibitor activity 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0005381 iron ion transmembrane transporter activity 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0005522 profilin binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0005528 FK506 binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0008190 eukaryotic initiation factor 4E binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0015643 toxic substance binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0016427 tRNA (cytidine) methyltransferase activity 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0035256 G protein-coupled glutamate receptor binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0043208 glycosphingolipid binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0098505 G-rich strand telomeric DNA binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0099122 RNA polymerase II C-terminal domain binding 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0141109 transporter activator activity 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:1990757 ubiquitin ligase activator activity 5/5871 10/18639 0.5 1.5873786407767 0.177088084975799 0.547395585654587 GO:0008374 O-acyltransferase activity 21/5871 55/18639 0.381818181818182 1.21218005295675 0.177205018258324 0.547395585654587 GO:0070717 poly-purine tract binding 13/5871 32/18639 0.40625 1.28974514563107 0.177286052122483 0.547395585654587 GO:0071813 lipoprotein particle binding 13/5871 32/18639 0.40625 1.28974514563107 0.177286052122483 0.547395585654587 GO:0071814 protein-lipid complex binding 13/5871 32/18639 0.40625 1.28974514563107 0.177286052122483 0.547395585654587 GO:0017116 single-stranded DNA helicase activity 22/5871 58/18639 0.379310344827586 1.20421827920991 0.179388959443524 0.552646704653367 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 23/5871 61/18639 0.377049180327869 1.19703963074964 0.181327281207572 0.557368421429986 GO:0016278 lysine N-methyltransferase activity 26/5871 70/18639 0.371428571428571 1.17919556171983 0.1859276897117 0.569345829166648 GO:1904047 S-adenosyl-L-methionine binding 9/5871 21/18639 0.428571428571429 1.36061026352288 0.186052603563191 0.569345829166648 GO:0042887 amide transmembrane transporter activity 15/5871 38/18639 0.394736842105263 1.25319366377108 0.186893306188187 0.570647561561263 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 118/5871 349/18639 0.33810888252149 1.07341363674298 0.188829686040937 0.574510696305687 GO:0004721 phosphoprotein phosphatase activity 61/5871 175/18639 0.348571428571429 1.10662968099861 0.189015143255732 0.574510696305687 GO:0008201 heparin binding 60/5871 172/18639 0.348837209302326 1.10747347030932 0.189412915157552 0.574510696305687 GO:0004812 aminoacyl-tRNA ligase activity 16/5871 41/18639 0.390243902439024 1.23892967085011 0.190705193160433 0.575887770115243 GO:0016875 ligase activity, forming carbon-oxygen bonds 16/5871 41/18639 0.390243902439024 1.23892967085011 0.190705193160433 0.575887770115243 GO:0051082 unfolded protein binding 43/5871 121/18639 0.355371900826446 1.12821952980823 0.193679599810261 0.579214906097532 GO:0019205 nucleobase-containing compound kinase activity 17/5871 44/18639 0.386363636363636 1.2266107678729 0.193996498682683 0.579214906097532 GO:0042625 ATPase-coupled ion transmembrane transporter activity 10/5871 24/18639 0.416666666666667 1.32281553398058 0.194757850521877 0.579214906097532 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 10/5871 24/18639 0.416666666666667 1.32281553398058 0.194757850521877 0.579214906097532 GO:0046961 proton-transporting ATPase activity, rotational mechanism 10/5871 24/18639 0.416666666666667 1.32281553398058 0.194757850521877 0.579214906097532 GO:0060229 lipase activator activity 10/5871 24/18639 0.416666666666667 1.32281553398058 0.194757850521877 0.579214906097532 GO:0070300 phosphatidic acid binding 10/5871 24/18639 0.416666666666667 1.32281553398058 0.194757850521877 0.579214906097532 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 6/5871 13/18639 0.461538461538462 1.46527259148618 0.197708201661757 0.581693938079775 GO:0005338 nucleotide-sugar transmembrane transporter activity 6/5871 13/18639 0.461538461538462 1.46527259148618 0.197708201661757 0.581693938079775 GO:0035673 oligopeptide transmembrane transporter activity 6/5871 13/18639 0.461538461538462 1.46527259148618 0.197708201661757 0.581693938079775 GO:0043560 insulin receptor substrate binding 6/5871 13/18639 0.461538461538462 1.46527259148618 0.197708201661757 0.581693938079775 GO:0046975 histone H3K36 methyltransferase activity 6/5871 13/18639 0.461538461538462 1.46527259148618 0.197708201661757 0.581693938079775 GO:0004864 protein phosphatase inhibitor activity 20/5871 53/18639 0.377358490566038 1.19802161568053 0.201464169563098 0.588740099747371 GO:0051018 protein kinase A binding 20/5871 53/18639 0.377358490566038 1.19802161568053 0.201464169563098 0.588740099747371 GO:1901505 carbohydrate derivative transmembrane transporter activity 20/5871 53/18639 0.377358490566038 1.19802161568053 0.201464169563098 0.588740099747371 GO:0004683 calcium/calmodulin-dependent protein kinase activity 11/5871 27/18639 0.407407407407407 1.29341963322546 0.201817021092439 0.588740099747371 GO:0019212 phosphatase inhibitor activity 21/5871 56/18639 0.375 1.19053398058252 0.203327873251765 0.591890885271027 GO:0004713 protein tyrosine kinase activity 49/5871 140/18639 0.35 1.11116504854369 0.209597294807988 0.608851338406292 GO:0035064 methylated histone binding 27/5871 74/18639 0.364864864864865 1.15835738651273 0.210243917457907 0.609161386055221 GO:0001540 amyloid-beta binding 30/5871 83/18639 0.36144578313253 1.14750263188677 0.211839272950083 0.609161386055221 GO:0004708 MAP kinase kinase activity 7/5871 16/18639 0.4375 1.38895631067961 0.212364122212846 0.609161386055221 GO:0005521 lamin binding 7/5871 16/18639 0.4375 1.38895631067961 0.212364122212846 0.609161386055221 GO:0015385 sodium:proton antiporter activity 7/5871 16/18639 0.4375 1.38895631067961 0.212364122212846 0.609161386055221 GO:0070411 I-SMAD binding 7/5871 16/18639 0.4375 1.38895631067961 0.212364122212846 0.609161386055221 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 15/5871 39/18639 0.384615384615385 1.22106049290515 0.219753118260322 0.629043301020173 GO:0019894 kinesin binding 16/5871 42/18639 0.380952380952381 1.20943134535368 0.222567604987105 0.633672464596736 GO:0048487 beta-tubulin binding 16/5871 42/18639 0.380952380952381 1.20943134535368 0.222567604987105 0.633672464596736 GO:0097001 ceramide binding 8/5871 19/18639 0.421052631578947 1.33673990802248 0.223215045753144 0.633672464596736 GO:0120227 acyl-CoA binding 8/5871 19/18639 0.421052631578947 1.33673990802248 0.223215045753144 0.633672464596736 GO:0140303 intramembrane lipid transporter activity 17/5871 45/18639 0.377777777777778 1.19935275080906 0.224936241228055 0.636430504771773 GO:0019842 vitamin binding 52/5871 150/18639 0.346666666666667 1.10058252427184 0.225112973303553 0.636430504771773 GO:0140693 molecular condensate scaffold activity 18/5871 48/18639 0.375 1.19053398058252 0.226929467843051 0.640248642333373 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 20/5871 54/18639 0.37037037037037 1.17583603020496 0.230005160586546 0.647596497225234 GO:0031683 G-protein beta/gamma-subunit complex binding 9/5871 22/18639 0.409090909090909 1.29876434245366 0.231480008406161 0.649088839898091 GO:0140035 ubiquitin-like protein reader activity 9/5871 22/18639 0.409090909090909 1.29876434245366 0.231480008406161 0.649088839898091 GO:0008237 metallopeptidase activity 63/5871 184/18639 0.342391304347826 1.08700928661883 0.232991115859479 0.651995505480499 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 62/5871 181/18639 0.342541436464088 1.08748591964813 0.233864823186349 0.653110298898463 GO:0005537 D-mannose binding 10/5871 25/18639 0.4 1.26990291262136 0.237902948725206 0.655790410682445 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 10/5871 25/18639 0.4 1.26990291262136 0.237902948725206 0.655790410682445 GO:0120020 cholesterol transfer activity 10/5871 25/18639 0.4 1.26990291262136 0.237902948725206 0.655790410682445 GO:0019789 SUMO transferase activity 11/5871 28/18639 0.392857142857143 1.24722607489598 0.242965419198825 0.655790410682445 GO:0046875 ephrin receptor binding 11/5871 28/18639 0.392857142857143 1.24722607489598 0.242965419198825 0.655790410682445 GO:0051019 mitogen-activated protein kinase binding 11/5871 28/18639 0.392857142857143 1.24722607489598 0.242965419198825 0.655790410682445 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0004016 adenylate cyclase activity 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0005536 D-glucose binding 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0008172 S-methyltransferase activity 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0008526 phosphatidylinositol transfer activity 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0019107 myristoyltransferase activity 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0032404 mismatch repair complex binding 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0032794 GTPase activating protein binding 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0034056 estrogen response element binding 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 5/5871 11/18639 0.454545454545455 1.44307149161518 0.24437022581471 0.655790410682445 GO:0140789 histone phosphatase activity 47/5871 136/18639 0.345588235294118 1.09715876641919 0.246858268658771 0.658969940857228 GO:0008327 methyl-CpG binding 12/5871 31/18639 0.387096774193548 1.2289383025368 0.246993827905002 0.658969940857228 GO:0016411 acylglycerol O-acyltransferase activity 12/5871 31/18639 0.387096774193548 1.2289383025368 0.246993827905002 0.658969940857228 GO:0016831 carboxy-lyase activity 13/5871 34/18639 0.382352941176471 1.21387778412336 0.250217761554607 0.666277527860524 GO:0017124 SH3 domain binding 40/5871 115/18639 0.347826086956522 1.10426340227944 0.252525748278572 0.669297129543773 GO:0032451 demethylase activity 15/5871 40/18639 0.375 1.19053398058252 0.254875381393321 0.669297129543773 GO:0061791 GTPase motor activity 15/5871 40/18639 0.375 1.19053398058252 0.254875381393321 0.669297129543773 GO:1990606 membrane scission GTPase motor activity 15/5871 40/18639 0.375 1.19053398058252 0.254875381393321 0.669297129543773 GO:0042562 hormone binding 33/5871 94/18639 0.351063829787234 1.11454244990704 0.25741009507916 0.669297129543773 GO:0004197 cysteine-type endopeptidase activity 31/5871 88/18639 0.352272727272727 1.11838040600177 0.258550363225669 0.669297129543773 GO:0005347 ATP transmembrane transporter activity 6/5871 14/18639 0.428571428571429 1.36061026352288 0.258658497662113 0.669297129543773 GO:0008195 phosphatidate phosphatase activity 6/5871 14/18639 0.428571428571429 1.36061026352288 0.258658497662113 0.669297129543773 GO:0008331 high voltage-gated calcium channel activity 6/5871 14/18639 0.428571428571429 1.36061026352288 0.258658497662113 0.669297129543773 GO:0019992 diacylglycerol binding 6/5871 14/18639 0.428571428571429 1.36061026352288 0.258658497662113 0.669297129543773 GO:0032454 histone H3K9 demethylase activity 6/5871 14/18639 0.428571428571429 1.36061026352288 0.258658497662113 0.669297129543773 GO:0034236 protein kinase A catalytic subunit binding 6/5871 14/18639 0.428571428571429 1.36061026352288 0.258658497662113 0.669297129543773 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 6/5871 14/18639 0.428571428571429 1.36061026352288 0.258658497662113 0.669297129543773 GO:0042043 neurexin family protein binding 6/5871 14/18639 0.428571428571429 1.36061026352288 0.258658497662113 0.669297129543773 GO:1901612 cardiolipin binding 6/5871 14/18639 0.428571428571429 1.36061026352288 0.258658497662113 0.669297129543773 GO:0140034 methylation-dependent protein binding 27/5871 76/18639 0.355263157894737 1.12787429739397 0.260278452444559 0.672222920411323 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 24/5871 67/18639 0.358208955223881 1.13722648891465 0.260877312336388 0.672505491839019 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 7/5871 17/18639 0.411764705882353 1.30725299828669 0.268422145192076 0.682985236099839 GO:0004549 tRNA-specific ribonuclease activity 7/5871 17/18639 0.411764705882353 1.30725299828669 0.268422145192076 0.682985236099839 GO:0015278 intracellularly gated calcium channel activity 7/5871 17/18639 0.411764705882353 1.30725299828669 0.268422145192076 0.682985236099839 GO:0030169 low-density lipoprotein particle binding 7/5871 17/18639 0.411764705882353 1.30725299828669 0.268422145192076 0.682985236099839 GO:0031489 myosin V binding 7/5871 17/18639 0.411764705882353 1.30725299828669 0.268422145192076 0.682985236099839 GO:0038191 neuropilin binding 7/5871 17/18639 0.411764705882353 1.30725299828669 0.268422145192076 0.682985236099839 GO:0070402 NADPH binding 7/5871 17/18639 0.411764705882353 1.30725299828669 0.268422145192076 0.682985236099839 GO:0000339 RNA cap binding 8/5871 20/18639 0.4 1.26990291262136 0.275353355687192 0.69546968881287 GO:0015095 magnesium ion transmembrane transporter activity 8/5871 20/18639 0.4 1.26990291262136 0.275353355687192 0.69546968881287 GO:0030742 GTP-dependent protein binding 8/5871 20/18639 0.4 1.26990291262136 0.275353355687192 0.69546968881287 GO:0140939 histone H4 methyltransferase activity 8/5871 20/18639 0.4 1.26990291262136 0.275353355687192 0.69546968881287 GO:0003887 DNA-directed DNA polymerase activity 9/5871 23/18639 0.391304347826087 1.24229632756437 0.280388395030466 0.701737076087178 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 9/5871 23/18639 0.391304347826087 1.24229632756437 0.280388395030466 0.701737076087178 GO:0017134 fibroblast growth factor binding 9/5871 23/18639 0.391304347826087 1.24229632756437 0.280388395030466 0.701737076087178 GO:0140102 catalytic activity, acting on a rRNA 9/5871 23/18639 0.391304347826087 1.24229632756437 0.280388395030466 0.701737076087178 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 9/5871 23/18639 0.391304347826087 1.24229632756437 0.280388395030466 0.701737076087178 GO:0005112 Notch binding 10/5871 26/18639 0.384615384615385 1.22106049290515 0.284090414928991 0.705859367291924 GO:0005160 transforming growth factor beta receptor binding 10/5871 26/18639 0.384615384615385 1.22106049290515 0.284090414928991 0.705859367291924 GO:0050681 nuclear androgen receptor binding 10/5871 26/18639 0.384615384615385 1.22106049290515 0.284090414928991 0.705859367291924 GO:0051139 metal cation:proton antiporter activity 10/5871 26/18639 0.384615384615385 1.22106049290515 0.284090414928991 0.705859367291924 GO:0048306 calcium-dependent protein binding 28/5871 80/18639 0.35 1.11116504854369 0.286057102580454 0.707865876981268 GO:0003678 DNA helicase activity 26/5871 74/18639 0.351351351351351 1.11545526108633 0.287812678459532 0.707865876981268 GO:0140299 molecular sensor activity 25/5871 71/18639 0.352112676056338 1.11787228223711 0.288628524257878 0.707865876981268 GO:0008378 galactosyltransferase activity 12/5871 32/18639 0.375 1.19053398058252 0.288818493374513 0.707865876981268 GO:0051059 NF-kappaB binding 12/5871 32/18639 0.375 1.19053398058252 0.288818493374513 0.707865876981268 GO:0120015 sterol transfer activity 12/5871 32/18639 0.375 1.19053398058252 0.288818493374513 0.707865876981268 GO:0005548 phospholipid transporter activity 24/5871 68/18639 0.352941176470588 1.12050256996002 0.289393969197516 0.707865876981268 GO:1990841 promoter-specific chromatin binding 24/5871 68/18639 0.352941176470588 1.12050256996002 0.289393969197516 0.707865876981268 GO:0010485 histone H4 acetyltransferase activity 13/5871 35/18639 0.371428571428571 1.17919556171983 0.290255227256429 0.707865876981268 GO:0043015 gamma-tubulin binding 13/5871 35/18639 0.371428571428571 1.17919556171983 0.290255227256429 0.707865876981268 GO:0070063 RNA polymerase binding 21/5871 59/18639 0.355932203389831 1.12999835445121 0.291296327890823 0.707865876981268 GO:0005003 ephrin receptor activity 19/5871 53/18639 0.358490566037736 1.1381205348965 0.292110591156025 0.707865876981268 GO:0005005 transmembrane-ephrin receptor activity 19/5871 53/18639 0.358490566037736 1.1381205348965 0.292110591156025 0.707865876981268 GO:0017046 peptide hormone binding 19/5871 53/18639 0.358490566037736 1.1381205348965 0.292110591156025 0.707865876981268 GO:0005516 calmodulin binding 69/5871 207/18639 0.333333333333333 1.05825242718447 0.307493888703474 0.743832047673545 GO:0004000 adenosine deaminase activity 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0005165 neurotrophin receptor binding 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0005247 voltage-gated chloride channel activity 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0005527 macrolide binding 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0008179 adenylate cyclase binding 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0016801 hydrolase activity, acting on ether bonds 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0016803 ether hydrolase activity 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0016840 carbon-nitrogen lyase activity 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0017166 vinculin binding 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0036009 protein-glutamine N-methyltransferase activity 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0070410 co-SMAD binding 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 5/5871 12/18639 0.416666666666667 1.32281553398058 0.316804974543566 0.74446283896556 GO:0002039 p53 binding 24/5871 69/18639 0.347826086956522 1.10426340227944 0.318918525464177 0.74446283896556 GO:0005041 low-density lipoprotein particle receptor activity 6/5871 15/18639 0.4 1.26990291262136 0.32361396896713 0.74446283896556 GO:0015556 C4-dicarboxylate transmembrane transporter activity 6/5871 15/18639 0.4 1.26990291262136 0.32361396896713 0.74446283896556 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 6/5871 15/18639 0.4 1.26990291262136 0.32361396896713 0.74446283896556 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 6/5871 15/18639 0.4 1.26990291262136 0.32361396896713 0.74446283896556 GO:0033130 acetylcholine receptor binding 6/5871 15/18639 0.4 1.26990291262136 0.32361396896713 0.74446283896556 GO:0120283 protein serine/threonine kinase binding 6/5871 15/18639 0.4 1.26990291262136 0.32361396896713 0.74446283896556 GO:0017069 snRNA binding 19/5871 54/18639 0.351851851851852 1.11704422869471 0.325824967750885 0.74446283896556 GO:0008308 voltage-gated monoatomic anion channel activity 7/5871 18/18639 0.388888888888889 1.23462783171521 0.32777618573002 0.74446283896556 GO:0008409 5'-3' exonuclease activity 7/5871 18/18639 0.388888888888889 1.23462783171521 0.32777618573002 0.74446283896556 GO:0008525 phosphatidylcholine transporter activity 7/5871 18/18639 0.388888888888889 1.23462783171521 0.32777618573002 0.74446283896556 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 7/5871 18/18639 0.388888888888889 1.23462783171521 0.32777618573002 0.74446283896556 GO:0017128 phospholipid scramblase activity 7/5871 18/18639 0.388888888888889 1.23462783171521 0.32777618573002 0.74446283896556 GO:0030228 lipoprotein particle receptor activity 7/5871 18/18639 0.388888888888889 1.23462783171521 0.32777618573002 0.74446283896556 GO:0031690 adrenergic receptor binding 7/5871 18/18639 0.388888888888889 1.23462783171521 0.32777618573002 0.74446283896556 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 7/5871 18/18639 0.388888888888889 1.23462783171521 0.32777618573002 0.74446283896556 GO:0016922 nuclear receptor binding 46/5871 137/18639 0.335766423357664 1.06597689745589 0.329171966797602 0.74446283896556 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 8/5871 21/18639 0.380952380952381 1.20943134535368 0.330307664686577 0.74446283896556 GO:0008373 sialyltransferase activity 8/5871 21/18639 0.380952380952381 1.20943134535368 0.330307664686577 0.74446283896556 GO:0043175 RNA polymerase core enzyme binding 15/5871 42/18639 0.357142857142857 1.13384188626907 0.330412776528853 0.74446283896556 GO:0051879 Hsp90 protein binding 15/5871 42/18639 0.357142857142857 1.13384188626907 0.330412776528853 0.74446283896556 GO:0004622 lysophospholipase activity 9/5871 24/18639 0.375 1.19053398058252 0.331766721735619 0.74446283896556 GO:0035035 histone acetyltransferase binding 9/5871 24/18639 0.375 1.19053398058252 0.331766721735619 0.74446283896556 GO:0140612 DNA damage sensor activity 9/5871 24/18639 0.375 1.19053398058252 0.331766721735619 0.74446283896556 GO:0030246 carbohydrate binding 92/5871 280/18639 0.328571428571429 1.04313453536755 0.331936718053073 0.74446283896556 GO:0055106 ubiquitin-protein transferase regulator activity 13/5871 36/18639 0.361111111111111 1.14644012944984 0.331997334667269 0.74446283896556 GO:0015252 proton channel activity 10/5871 27/18639 0.37037037037037 1.17583603020496 0.332486528950492 0.74446283896556 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 10/5871 27/18639 0.37037037037037 1.17583603020496 0.332486528950492 0.74446283896556 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 10/5871 27/18639 0.37037037037037 1.17583603020496 0.332486528950492 0.74446283896556 GO:0001965 G-protein alpha-subunit binding 11/5871 30/18639 0.366666666666667 1.16407766990291 0.332678444777914 0.74446283896556 GO:0035925 mRNA 3'-UTR AU-rich region binding 11/5871 30/18639 0.366666666666667 1.16407766990291 0.332678444777914 0.74446283896556 GO:0072341 modified amino acid binding 31/5871 91/18639 0.340659340659341 1.08151072228742 0.334838327939881 0.748077825348613 GO:0004222 metalloendopeptidase activity 37/5871 110/18639 0.336363636363636 1.06787290379523 0.347638519336187 0.775414489558312 GO:0004725 protein tyrosine phosphatase activity 33/5871 98/18639 0.336734693877551 1.06905092133941 0.356766134245944 0.791642928842191 GO:0035591 signaling adaptor activity 43/5871 129/18639 0.333333333333333 1.05825242718447 0.357545296168564 0.791642928842191 GO:0052689 carboxylic ester hydrolase activity 31/5871 92/18639 0.33695652173913 1.06975517095821 0.361592749500636 0.791642928842191 GO:0030159 signaling receptor complex adaptor activity 18/5871 52/18639 0.346153846153846 1.09895444361464 0.362809826570609 0.791642928842191 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 30/5871 89/18639 0.337078651685393 1.0701429038944 0.364079663148329 0.791642928842191 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 30/5871 89/18639 0.337078651685393 1.0701429038944 0.364079663148329 0.791642928842191 GO:0001222 transcription corepressor binding 17/5871 49/18639 0.346938775510204 1.10144640380424 0.365177223789727 0.791642928842191 GO:0030165 PDZ domain binding 28/5871 83/18639 0.337349397590361 1.07100245642765 0.369214372760251 0.791642928842191 GO:0005245 voltage-gated calcium channel activity 15/5871 43/18639 0.348837209302326 1.10747347030932 0.369994487018259 0.791642928842191 GO:0043394 proteoglycan binding 13/5871 37/18639 0.351351351351351 1.11545526108633 0.374893896427563 0.791642928842191 GO:0008376 acetylgalactosaminyltransferase activity 12/5871 34/18639 0.352941176470588 1.12050256996002 0.37735499476546 0.791642928842191 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 12/5871 34/18639 0.352941176470588 1.12050256996002 0.37735499476546 0.791642928842191 GO:0030332 cyclin binding 12/5871 34/18639 0.352941176470588 1.12050256996002 0.37735499476546 0.791642928842191 GO:0090482 vitamin transmembrane transporter activity 12/5871 34/18639 0.352941176470588 1.12050256996002 0.37735499476546 0.791642928842191 GO:0003779 actin binding 143/5871 443/18639 0.322799097065463 1.02480878388744 0.377496810382742 0.791642928842191 GO:0016878 acid-thiol ligase activity 11/5871 31/18639 0.354838709677419 1.1265267773254 0.379804984058016 0.791642928842191 GO:0016298 lipase activity 43/5871 130/18639 0.330769230769231 1.05011202389843 0.380398837951621 0.791642928842191 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 43/5871 130/18639 0.330769230769231 1.05011202389843 0.380398837951621 0.791642928842191 GO:0036408 histone H3K14 acetyltransferase activity 10/5871 28/18639 0.357142857142857 1.13384188626907 0.38222047881253 0.791642928842191 GO:0045499 chemorepellent activity 10/5871 28/18639 0.357142857142857 1.13384188626907 0.38222047881253 0.791642928842191 GO:0046966 nuclear thyroid hormone receptor binding 10/5871 28/18639 0.357142857142857 1.13384188626907 0.38222047881253 0.791642928842191 GO:0042826 histone deacetylase binding 42/5871 127/18639 0.330708661417323 1.04991973090742 0.383047801158825 0.791642928842191 GO:0140223 general transcription initiation factor activity 23/5871 68/18639 0.338235294117647 1.07381496287836 0.383152610515601 0.791642928842191 GO:0017025 TBP-class protein binding 9/5871 25/18639 0.36 1.14291262135922 0.384565094053977 0.791642928842191 GO:0008093 cytoskeletal anchor activity 8/5871 22/18639 0.363636363636364 1.15445719329214 0.386780611132529 0.791642928842191 GO:0008649 rRNA methyltransferase activity 8/5871 22/18639 0.363636363636364 1.15445719329214 0.386780611132529 0.791642928842191 GO:0016881 acid-amino acid ligase activity 8/5871 22/18639 0.363636363636364 1.15445719329214 0.386780611132529 0.791642928842191 GO:0061133 endopeptidase activator activity 8/5871 22/18639 0.363636363636364 1.15445719329214 0.386780611132529 0.791642928842191 GO:0042800 histone H3K4 methyltransferase activity 7/5871 19/18639 0.368421052631579 1.16964741951967 0.388770184049863 0.791642928842191 GO:0043395 heparan sulfate proteoglycan binding 7/5871 19/18639 0.368421052631579 1.16964741951967 0.388770184049863 0.791642928842191 GO:1990380 K48-linked deubiquitinase activity 7/5871 19/18639 0.368421052631579 1.16964741951967 0.388770184049863 0.791642928842191 GO:0000062 fatty-acyl-CoA binding 6/5871 16/18639 0.375 1.19053398058252 0.390363877019702 0.791642928842191 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 6/5871 16/18639 0.375 1.19053398058252 0.390363877019702 0.791642928842191 GO:0005324 long-chain fatty acid transmembrane transporter activity 6/5871 16/18639 0.375 1.19053398058252 0.390363877019702 0.791642928842191 GO:0017070 U6 snRNA binding 6/5871 16/18639 0.375 1.19053398058252 0.390363877019702 0.791642928842191 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 6/5871 16/18639 0.375 1.19053398058252 0.390363877019702 0.791642928842191 GO:0140328 floppase activity 6/5871 16/18639 0.375 1.19053398058252 0.390363877019702 0.791642928842191 GO:0004382 GDP phosphatase activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0008140 cAMP response element binding protein binding 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0015187 glycine transmembrane transporter activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0015279 store-operated calcium channel activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0030957 Tat protein binding 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0031419 cobalamin binding 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0031434 mitogen-activated protein kinase kinase binding 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0031957 very long-chain fatty acid-CoA ligase activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0032356 oxidized DNA binding 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0033204 ribonuclease P RNA binding 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0047429 nucleoside triphosphate diphosphatase activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0070097 delta-catenin binding 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0070739 protein-glutamic acid ligase activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0070740 tubulin-glutamic acid ligase activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0140135 mechanosensitive monoatomic cation channel activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0140940 histone H2A methyltransferase activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:1990259 histone H2AQ104 methyltransferase activity 4/5871 10/18639 0.4 1.26990291262136 0.390723503705657 0.791642928842191 GO:0005172 vascular endothelial growth factor receptor binding 5/5871 13/18639 0.384615384615385 1.22106049290515 0.391240457594698 0.791642928842191 GO:0008035 high-density lipoprotein particle binding 5/5871 13/18639 0.384615384615385 1.22106049290515 0.391240457594698 0.791642928842191 GO:0008417 fucosyltransferase activity 5/5871 13/18639 0.384615384615385 1.22106049290515 0.391240457594698 0.791642928842191 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 5/5871 13/18639 0.384615384615385 1.22106049290515 0.391240457594698 0.791642928842191 GO:0019855 calcium channel inhibitor activity 5/5871 13/18639 0.384615384615385 1.22106049290515 0.391240457594698 0.791642928842191 GO:0030955 potassium ion binding 5/5871 13/18639 0.384615384615385 1.22106049290515 0.391240457594698 0.791642928842191 GO:0051011 microtubule minus-end binding 5/5871 13/18639 0.384615384615385 1.22106049290515 0.391240457594698 0.791642928842191 GO:0140852 histone ubiquitin ligase activity 5/5871 13/18639 0.384615384615385 1.22106049290515 0.391240457594698 0.791642928842191 GO:0140793 histone H2AXY142 phosphatase activity 30/5871 90/18639 0.333333333333333 1.05825242718447 0.391788349063093 0.791642928842191 GO:0030170 pyridoxal phosphate binding 19/5871 56/18639 0.339285714285714 1.07714979195562 0.395757911193026 0.798489530072273 GO:0051087 protein-folding chaperone binding 44/5871 134/18639 0.328358208955224 1.04245761483843 0.400629386299743 0.807133103776902 GO:0001618 virus receptor activity 27/5871 81/18639 0.333333333333333 1.05825242718447 0.401263649679925 0.807227312826086 GO:0005006 epidermal growth factor receptor activity 17/5871 50/18639 0.34 1.07941747572816 0.402705015871176 0.807761593878827 GO:0005007 fibroblast growth factor receptor activity 17/5871 50/18639 0.34 1.07941747572816 0.402705015871176 0.807761593878827 GO:0035402 histone H3T11 kinase activity 80/5871 247/18639 0.323886639676113 1.0282614677096 0.404386077219021 0.809181700489387 GO:0005319 lipid transporter activity 58/5871 178/18639 0.325842696629214 1.03447147376459 0.404590850244693 0.809181700489387 GO:0140938 histone H3 methyltransferase activity 16/5871 47/18639 0.340425531914894 1.0807684362735 0.406377644518615 0.810617804937252 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 42/5871 128/18639 0.328125 1.04171723300971 0.406488841049321 0.810617804937252 GO:0001727 lipid kinase activity 14/5871 41/18639 0.341463414634146 1.08406346199384 0.414198681710286 0.824123570475281 GO:0019955 cytokine binding 47/5871 144/18639 0.326388888888889 1.03620550161812 0.414460980493755 0.824123570475281 GO:0016229 steroid dehydrogenase activity 12/5871 35/18639 0.342857142857143 1.08848821081831 0.422798351726694 0.838275519873705 GO:0034061 DNA polymerase activity 12/5871 35/18639 0.342857142857143 1.08848821081831 0.422798351726694 0.838275519873705 GO:0015297 antiporter activity 44/5871 135/18639 0.325925925925926 1.03473570658037 0.423660844092608 0.838775215825999 GO:0030515 snoRNA binding 11/5871 32/18639 0.34375 1.09132281553398 0.427464574416041 0.842663307385425 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 11/5871 32/18639 0.34375 1.09132281553398 0.427464574416041 0.842663307385425 GO:0042910 xenobiotic transmembrane transporter activity 11/5871 32/18639 0.34375 1.09132281553398 0.427464574416041 0.842663307385425 GO:0140272 exogenous protein binding 27/5871 82/18639 0.329268292682927 1.04534690977978 0.430922195815518 0.843978254303112 GO:0070279 vitamin B6 binding 19/5871 57/18639 0.333333333333333 1.05825242718447 0.431382026395689 0.843978254303112 GO:0003785 actin monomer binding 10/5871 29/18639 0.344827586206897 1.09474389019083 0.432431361739004 0.843978254303112 GO:0004629 phospholipase C activity 10/5871 29/18639 0.344827586206897 1.09474389019083 0.432431361739004 0.843978254303112 GO:0010484 histone H3 acetyltransferase activity 10/5871 29/18639 0.344827586206897 1.09474389019083 0.432431361739004 0.843978254303112 GO:0035250 UDP-galactosyltransferase activity 10/5871 29/18639 0.344827586206897 1.09474389019083 0.432431361739004 0.843978254303112 GO:0043236 laminin binding 10/5871 29/18639 0.344827586206897 1.09474389019083 0.432431361739004 0.843978254303112 GO:0022804 active transmembrane transporter activity 146/5871 457/18639 0.319474835886214 1.01425506150284 0.434846697162391 0.84748845659734 GO:0004435 phosphatidylinositol phospholipase C activity 9/5871 26/18639 0.346153846153846 1.09895444361464 0.437757571237794 0.848348241016543 GO:0008143 poly(A) binding 9/5871 26/18639 0.346153846153846 1.09895444361464 0.437757571237794 0.848348241016543 GO:0030507 spectrin binding 9/5871 26/18639 0.346153846153846 1.09895444361464 0.437757571237794 0.848348241016543 GO:0120014 phospholipid transfer activity 9/5871 26/18639 0.346153846153846 1.09895444361464 0.437757571237794 0.848348241016543 GO:0017022 myosin binding 25/5871 76/18639 0.328947368421053 1.04432805314257 0.438952882894302 0.84946656492503 GO:0005010 insulin-like growth factor receptor activity 17/5871 51/18639 0.333333333333333 1.05825242718447 0.440513304783125 0.850091686477548 GO:0005021 vascular endothelial growth factor receptor activity 17/5871 51/18639 0.333333333333333 1.05825242718447 0.440513304783125 0.850091686477548 GO:0043274 phospholipase binding 8/5871 23/18639 0.347826086956522 1.10426340227944 0.443523126386962 0.853502486912725 GO:0044013 histone H2B acetyltransferase activity 8/5871 23/18639 0.347826086956522 1.10426340227944 0.443523126386962 0.853502486912725 GO:0016782 transferase activity, transferring sulphur-containing groups 23/5871 70/18639 0.328571428571429 1.04313453536755 0.447571716579892 0.855359800209001 GO:0010851 cyclase regulator activity 7/5871 20/18639 0.35 1.11116504854369 0.449840783937456 0.855359800209001 GO:0042288 MHC class I protein binding 7/5871 20/18639 0.35 1.11116504854369 0.449840783937456 0.855359800209001 GO:0140664 ATP-dependent DNA damage sensor activity 7/5871 20/18639 0.35 1.11116504854369 0.449840783937456 0.855359800209001 GO:0003727 single-stranded RNA binding 29/5871 89/18639 0.325842696629214 1.03447147376459 0.452062566900276 0.855359800209001 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 28/5871 86/18639 0.325581395348837 1.03364190562204 0.456297433870024 0.855359800209001 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 6/5871 17/18639 0.352941176470588 1.12050256996002 0.456877548925679 0.855359800209001 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 6/5871 17/18639 0.352941176470588 1.12050256996002 0.456877548925679 0.855359800209001 GO:0019198 transmembrane receptor protein phosphatase activity 6/5871 17/18639 0.352941176470588 1.12050256996002 0.456877548925679 0.855359800209001 GO:0030548 acetylcholine receptor regulator activity 6/5871 17/18639 0.352941176470588 1.12050256996002 0.456877548925679 0.855359800209001 GO:0046965 nuclear retinoid X receptor binding 6/5871 17/18639 0.352941176470588 1.12050256996002 0.456877548925679 0.855359800209001 GO:1901567 fatty acid derivative binding 6/5871 17/18639 0.352941176470588 1.12050256996002 0.456877548925679 0.855359800209001 GO:0035403 histone H3T6 kinase activity 79/5871 247/18639 0.319838056680162 1.01540819936323 0.458370262220071 0.855359800209001 GO:0042393 histone binding 79/5871 247/18639 0.319838056680162 1.01540819936323 0.458370262220071 0.855359800209001 GO:0005313 L-glutamate transmembrane transporter activity 5/5871 14/18639 0.357142857142857 1.13384188626907 0.464897102001689 0.855359800209001 GO:0015386 potassium:proton antiporter activity 5/5871 14/18639 0.357142857142857 1.13384188626907 0.464897102001689 0.855359800209001 GO:0015926 glucosidase activity 5/5871 14/18639 0.357142857142857 1.13384188626907 0.464897102001689 0.855359800209001 GO:0031404 chloride ion binding 5/5871 14/18639 0.357142857142857 1.13384188626907 0.464897102001689 0.855359800209001 GO:0032036 myosin heavy chain binding 5/5871 14/18639 0.357142857142857 1.13384188626907 0.464897102001689 0.855359800209001 GO:0061665 SUMO ligase activity 5/5871 14/18639 0.357142857142857 1.13384188626907 0.464897102001689 0.855359800209001 GO:0070742 C2H2 zinc finger domain binding 5/5871 14/18639 0.357142857142857 1.13384188626907 0.464897102001689 0.855359800209001 GO:1901474 azole transmembrane transporter activity 5/5871 14/18639 0.357142857142857 1.13384188626907 0.464897102001689 0.855359800209001 GO:0000993 RNA polymerase II complex binding 12/5871 36/18639 0.333333333333333 1.05825242718447 0.468198860256406 0.855359800209001 GO:0140313 molecular sequestering activity 18/5871 55/18639 0.327272727272727 1.03901147396293 0.472507659328358 0.855359800209001 GO:0002162 dystroglycan binding 4/5871 11/18639 0.363636363636364 1.15445719329214 0.474353948214769 0.855359800209001 GO:0005114 type II transforming growth factor beta receptor binding 4/5871 11/18639 0.363636363636364 1.15445719329214 0.474353948214769 0.855359800209001 GO:0005225 volume-sensitive anion channel activity 4/5871 11/18639 0.363636363636364 1.15445719329214 0.474353948214769 0.855359800209001 GO:0015217 ADP transmembrane transporter activity 4/5871 11/18639 0.363636363636364 1.15445719329214 0.474353948214769 0.855359800209001 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 4/5871 11/18639 0.363636363636364 1.15445719329214 0.474353948214769 0.855359800209001 GO:0034713 type I transforming growth factor beta receptor binding 4/5871 11/18639 0.363636363636364 1.15445719329214 0.474353948214769 0.855359800209001 GO:0045294 alpha-catenin binding 4/5871 11/18639 0.363636363636364 1.15445719329214 0.474353948214769 0.855359800209001 GO:0140311 protein sequestering activity 11/5871 33/18639 0.333333333333333 1.05825242718447 0.474955346572659 0.855359800209001 GO:0004679 AMP-activated protein kinase activity 79/5871 248/18639 0.318548387096774 1.01131381146257 0.475658412248655 0.855359800209001 GO:0004676 3-phosphoinositide-dependent protein kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0004711 ribosomal protein S6 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0035175 histone H3S10 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0035979 histone H2AXS139 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0044022 histone H3S28 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0044023 histone H4S1 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0044024 histone H2AS1 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0044025 histone H2BS14 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0072354 histone H3T3 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0072371 histone H2AS121 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0072518 Rho-dependent protein serine/threonine kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0140823 histone H2BS36 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0140855 histone H3S57 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0140995 histone H2A kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0140997 histone H4 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0140998 histone H2B kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:1990244 histone H2AT120 kinase activity 78/5871 245/18639 0.318367346938775 1.01073905290271 0.478542691612941 0.855359800209001 GO:0004620 phospholipase activity 35/5871 109/18639 0.321100917431193 1.01941747572816 0.481222225203719 0.855359800209001 GO:0043995 histone H4K5 acetyltransferase activity 10/5871 30/18639 0.333333333333333 1.05825242718447 0.482307820219548 0.855359800209001 GO:0043996 histone H4K8 acetyltransferase activity 10/5871 30/18639 0.333333333333333 1.05825242718447 0.482307820219548 0.855359800209001 GO:0043997 histone H4K12 acetyltransferase activity 10/5871 30/18639 0.333333333333333 1.05825242718447 0.482307820219548 0.855359800209001 GO:0005004 GPI-linked ephrin receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0005008 hepatocyte growth factor receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0005009 insulin receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0005011 macrophage colony-stimulating factor receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0005018 platelet-derived growth factor alpha-receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0005020 stem cell factor receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0008288 boss receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0036332 placental growth factor receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0038062 protein tyrosine kinase collagen receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0060175 brain-derived neurotrophic factor receptor activity 16/5871 49/18639 0.326530612244898 1.03665543887458 0.484330367221691 0.855359800209001 GO:0008081 phosphoric diester hydrolase activity 28/5871 87/18639 0.32183908045977 1.02176096417811 0.485453198421531 0.85624222674093 GO:0004722 protein serine/threonine phosphatase activity 33/5871 103/18639 0.320388349514563 1.01715524554623 0.490003751250264 0.862740216302311 GO:0004364 glutathione transferase activity 9/5871 27/18639 0.333333333333333 1.05825242718447 0.490393092381445 0.862740216302311 GO:0035173 histone kinase activity 114/5871 360/18639 0.316666666666667 1.00533980582524 0.492465637037997 0.865278497813565 GO:0140996 histone H3 kinase activity 113/5871 357/18639 0.316526610644258 1.00489516194827 0.494958834086958 0.868026531992111 GO:0004677 DNA-dependent protein kinase activity 78/5871 246/18639 0.317073170731707 1.00663035756571 0.495924910927079 0.868026531992111 GO:0140857 histone H3T45 kinase activity 78/5871 246/18639 0.317073170731707 1.00663035756571 0.495924910927079 0.868026531992111 GO:0030215 semaphorin receptor binding 8/5871 24/18639 0.333333333333333 1.05825242718447 0.499401328712634 0.871889994474153 GO:0070840 dynein complex binding 8/5871 24/18639 0.333333333333333 1.05825242718447 0.499401328712634 0.871889994474153 GO:0001786 phosphatidylserine binding 19/5871 59/18639 0.322033898305085 1.02237946355109 0.502481979360424 0.875044663677088 GO:0045309 protein phosphorylated amino acid binding 19/5871 59/18639 0.322033898305085 1.02237946355109 0.502481979360424 0.875044663677088 GO:0030331 nuclear estrogen receptor binding 13/5871 40/18639 0.325 1.03179611650485 0.505029247806681 0.877256872928419 GO:0140662 ATP-dependent protein folding chaperone 13/5871 40/18639 0.325 1.03179611650485 0.505029247806681 0.877256872928419 GO:0044183 protein folding chaperone 24/5871 75/18639 0.32 1.01592233009709 0.506174718359233 0.878136443214124 GO:0003746 translation elongation factor activity 6/5871 18/18639 0.333333333333333 1.05825242718447 0.521428230523509 0.898923950739399 GO:0004706 JUN kinase kinase kinase activity 6/5871 18/18639 0.333333333333333 1.05825242718447 0.521428230523509 0.898923950739399 GO:0015280 ligand-gated sodium channel activity 6/5871 18/18639 0.333333333333333 1.05825242718447 0.521428230523509 0.898923950739399 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 6/5871 18/18639 0.333333333333333 1.05825242718447 0.521428230523509 0.898923950739399 GO:0099602 neurotransmitter receptor regulator activity 6/5871 18/18639 0.333333333333333 1.05825242718447 0.521428230523509 0.898923950739399 GO:0005017 platelet-derived growth factor receptor activity 16/5871 50/18639 0.32 1.01592233009709 0.522742297268992 0.898933562512634 GO:0005019 platelet-derived growth factor beta-receptor activity 16/5871 50/18639 0.32 1.01592233009709 0.522742297268992 0.898933562512634 GO:0001784 phosphotyrosine residue binding 15/5871 47/18639 0.319148936170213 1.0132204090064 0.530342007325609 0.90508011137154 GO:0072349 modified amino acid transmembrane transporter activity 10/5871 31/18639 0.32258064516129 1.024115252114 0.531118694582182 0.90508011137154 GO:0140457 protein demethylase activity 10/5871 31/18639 0.32258064516129 1.024115252114 0.531118694582182 0.90508011137154 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0004865 protein serine/threonine phosphatase inhibitor activity 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0005402 carbohydrate:monoatomic cation symporter activity 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0008242 omega peptidase activity 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0031386 protein tag activity 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0042809 nuclear vitamin D receptor binding 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0047372 monoacylglycerol lipase activity 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0048531 beta-1,3-galactosyltransferase activity 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0051371 muscle alpha-actinin binding 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0141047 molecular tag activity 5/5871 15/18639 0.333333333333333 1.05825242718447 0.535538668518968 0.90508011137154 GO:0043014 alpha-tubulin binding 14/5871 44/18639 0.318181818181818 1.01015004413063 0.538467203266812 0.908911470870516 GO:0046625 sphingolipid binding 9/5871 28/18639 0.321428571428571 1.02045769764216 0.541632751440404 0.912013971175386 GO:0050698 proteoglycan sulfotransferase activity 9/5871 28/18639 0.321428571428571 1.02045769764216 0.541632751440404 0.912013971175386 GO:0141003 histone H2AX kinase activity 111/5871 354/18639 0.313559322033898 0.995474740826065 0.543497491500263 0.914033724995547 GO:0061650 ubiquitin-like protein conjugating enzyme activity 13/5871 41/18639 0.317073170731707 1.00663035756571 0.547200582065721 0.91617973971918 GO:0035401 histone H3Y41 kinase activity 36/5871 115/18639 0.31304347826087 0.993837062051499 0.553082543739716 0.91617973971918 GO:0140801 histone H2AXY142 kinase activity 36/5871 115/18639 0.31304347826087 0.993837062051499 0.553082543739716 0.91617973971918 GO:0000340 RNA 7-methylguanosine cap binding 4/5871 12/18639 0.333333333333333 1.05825242718447 0.55312843505037 0.91617973971918 GO:0004526 ribonuclease P activity 4/5871 12/18639 0.333333333333333 1.05825242718447 0.55312843505037 0.91617973971918 GO:0010853 cyclase activator activity 4/5871 12/18639 0.333333333333333 1.05825242718447 0.55312843505037 0.91617973971918 GO:0016208 AMP binding 4/5871 12/18639 0.333333333333333 1.05825242718447 0.55312843505037 0.91617973971918 GO:0016273 arginine N-methyltransferase activity 4/5871 12/18639 0.333333333333333 1.05825242718447 0.55312843505037 0.91617973971918 GO:0016274 protein-arginine N-methyltransferase activity 4/5871 12/18639 0.333333333333333 1.05825242718447 0.55312843505037 0.91617973971918 GO:0045295 gamma-catenin binding 4/5871 12/18639 0.333333333333333 1.05825242718447 0.55312843505037 0.91617973971918 GO:0015271 outward rectifier potassium channel activity 8/5871 25/18639 0.32 1.01592233009709 0.553441909728471 0.91617973971918 GO:0015662 P-type ion transporter activity 8/5871 25/18639 0.32 1.01592233009709 0.553441909728471 0.91617973971918 GO:0140358 P-type transmembrane transporter activity 8/5871 25/18639 0.32 1.01592233009709 0.553441909728471 0.91617973971918 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 76/5871 243/18639 0.312757201646091 0.99292820328419 0.554286981008101 0.916474502894262 GO:0005030 neurotrophin receptor activity 16/5871 51/18639 0.313725490196078 0.996002284408909 0.560332693833959 0.919676996522626 GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0032931 histone H3K56 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0043992 histone H3K9 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0043993 histone H3K18 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0043994 histone H3K23 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0043999 histone H2AK5 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0044012 histone H2AK9 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0044014 histone H2BK5 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0044015 histone H2BK12 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0044016 histone H3K4 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0044017 histone H3K27 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0044018 histone H3K36 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0046972 histone H4K16 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0140908 histone H3K122 acetyltransferase activity 7/5871 22/18639 0.318181818181818 1.01015004413063 0.566926485363734 0.919676996522626 GO:0061631 ubiquitin conjugating enzyme activity 11/5871 35/18639 0.314285714285714 0.997780859916782 0.566933345017951 0.919676996522626 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 6/5871 19/18639 0.315789473684211 1.00255493101686 0.582655021203653 0.935242989642312 GO:0005229 intracellularly calcium-gated chloride channel activity 6/5871 19/18639 0.315789473684211 1.00255493101686 0.582655021203653 0.935242989642312 GO:0015245 fatty acid transmembrane transporter activity 6/5871 19/18639 0.315789473684211 1.00255493101686 0.582655021203653 0.935242989642312 GO:0022821 solute:potassium antiporter activity 6/5871 19/18639 0.315789473684211 1.00255493101686 0.582655021203653 0.935242989642312 GO:0031420 alkali metal ion binding 6/5871 19/18639 0.315789473684211 1.00255493101686 0.582655021203653 0.935242989642312 GO:0046624 sphingolipid transporter activity 6/5871 19/18639 0.315789473684211 1.00255493101686 0.582655021203653 0.935242989642312 GO:0070003 threonine-type peptidase activity 6/5871 19/18639 0.315789473684211 1.00255493101686 0.582655021203653 0.935242989642312 GO:0140036 ubiquitin-modified protein reader activity 6/5871 19/18639 0.315789473684211 1.00255493101686 0.582655021203653 0.935242989642312 GO:0141147 intracellularly calcium-gated channel activity 6/5871 19/18639 0.315789473684211 1.00255493101686 0.582655021203653 0.935242989642312 GO:0033192 calmodulin-dependent protein phosphatase activity 25/5871 81/18639 0.308641975308642 0.979863358504135 0.590506204691303 0.937324041260383 GO:0140791 histone H2AXS140 phosphatase activity 25/5871 81/18639 0.308641975308642 0.979863358504135 0.590506204691303 0.937324041260383 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 25/5871 81/18639 0.308641975308642 0.979863358504135 0.590506204691303 0.937324041260383 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 25/5871 81/18639 0.308641975308642 0.979863358504135 0.590506204691303 0.937324041260383 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 25/5871 81/18639 0.308641975308642 0.979863358504135 0.590506204691303 0.937324041260383 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 25/5871 81/18639 0.308641975308642 0.979863358504135 0.590506204691303 0.937324041260383 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 25/5871 81/18639 0.308641975308642 0.979863358504135 0.590506204691303 0.937324041260383 GO:1990439 MAP kinase serine/threonine phosphatase activity 25/5871 81/18639 0.308641975308642 0.979863358504135 0.590506204691303 0.937324041260383 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 9/5871 29/18639 0.310344827586207 0.985269501171744 0.590773376806035 0.937324041260383 GO:0099604 ligand-gated calcium channel activity 9/5871 29/18639 0.310344827586207 0.985269501171744 0.590773376806035 0.937324041260383 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 83/5871 268/18639 0.309701492537313 0.983227068540791 0.597256930154117 0.944569584789158 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 5/5871 16/18639 0.3125 0.992111650485437 0.601527210109544 0.944569584789158 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/5871 16/18639 0.3125 0.992111650485437 0.601527210109544 0.944569584789158 GO:0022841 potassium ion leak channel activity 5/5871 16/18639 0.3125 0.992111650485437 0.601527210109544 0.944569584789158 GO:0022858 alanine transmembrane transporter activity 5/5871 16/18639 0.3125 0.992111650485437 0.601527210109544 0.944569584789158 GO:0030275 LRR domain binding 5/5871 16/18639 0.3125 0.992111650485437 0.601527210109544 0.944569584789158 GO:0031435 mitogen-activated protein kinase kinase kinase binding 5/5871 16/18639 0.3125 0.992111650485437 0.601527210109544 0.944569584789158 GO:0043023 ribosomal large subunit binding 5/5871 16/18639 0.3125 0.992111650485437 0.601527210109544 0.944569584789158 GO:0140327 flippase activity 5/5871 16/18639 0.3125 0.992111650485437 0.601527210109544 0.944569584789158 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 8/5871 26/18639 0.307692307692308 0.976848394324123 0.604857171279883 0.945476397427258 GO:0030247 polysaccharide binding 8/5871 26/18639 0.307692307692308 0.976848394324123 0.604857171279883 0.945476397427258 GO:0052742 phosphatidylinositol kinase activity 8/5871 26/18639 0.307692307692308 0.976848394324123 0.604857171279883 0.945476397427258 GO:0070412 R-SMAD binding 8/5871 26/18639 0.307692307692308 0.976848394324123 0.604857171279883 0.945476397427258 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 25/5871 82/18639 0.304878048780488 0.967913805351646 0.619070198922811 0.964804083862593 GO:0033549 MAP kinase phosphatase activity 25/5871 82/18639 0.304878048780488 0.967913805351646 0.619070198922811 0.964804083862593 GO:0004843 cysteine-type deubiquitinase activity 33/5871 108/18639 0.305555555555556 0.970064724919094 0.619328385710922 0.964804083862593 GO:0070577 lysine-acetylated histone binding 7/5871 23/18639 0.304347826086957 0.966230476994512 0.620915454916071 0.96609455717151 GO:0005035 death receptor activity 4/5871 13/18639 0.307692307692308 0.976848394324123 0.625078647252891 0.96609455717151 GO:0031432 titin binding 4/5871 13/18639 0.307692307692308 0.976848394324123 0.625078647252891 0.96609455717151 GO:0039706 co-receptor binding 4/5871 13/18639 0.307692307692308 0.976848394324123 0.625078647252891 0.96609455717151 GO:0045159 myosin II binding 4/5871 13/18639 0.307692307692308 0.976848394324123 0.625078647252891 0.96609455717151 GO:0071714 icosanoid transmembrane transporter activity 4/5871 13/18639 0.307692307692308 0.976848394324123 0.625078647252891 0.96609455717151 GO:0140333 glycerophospholipid flippase activity 4/5871 13/18639 0.307692307692308 0.976848394324123 0.625078647252891 0.96609455717151 GO:0005262 calcium channel activity 40/5871 131/18639 0.305343511450382 0.969391536352183 0.626387063824663 0.96702901763493 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 13/5871 43/18639 0.302325581395349 0.959810340934748 0.627210115746546 0.967212905764034 GO:0101005 deubiquitinase activity 35/5871 115/18639 0.304347826086957 0.966230476994512 0.63152843214581 0.9712209981482 GO:0005246 calcium channel regulator activity 16/5871 53/18639 0.30188679245283 0.958417292544422 0.631929819755816 0.9712209981482 GO:0038064 collagen receptor activity 16/5871 53/18639 0.30188679245283 0.958417292544422 0.631929819755816 0.9712209981482 GO:0008106 alcohol dehydrogenase (NADP+) activity 9/5871 30/18639 0.3 0.952427184466019 0.6372586153431 0.977224707010513 GO:0032452 histone demethylase activity 9/5871 30/18639 0.3 0.952427184466019 0.6372586153431 0.977224707010513 GO:0016209 antioxidant activity 26/5871 86/18639 0.302325581395349 0.959810340934748 0.639425039461265 0.97945373937545 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 25/5871 83/18639 0.301204819277108 0.956252193238975 0.646731763863905 0.985410405026044 GO:0001217 DNA-binding transcription repressor activity 85/5871 278/18639 0.305755395683453 0.970699168820284 0.652526173586114 0.985410405026044 GO:0016504 peptidase activator activity 17/5871 57/18639 0.298245614035088 0.946857434849259 0.655427890955961 0.985410405026044 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0004090 carbonyl reductase (NADPH) activity 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0005031 tumor necrosis factor receptor activity 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0008401 retinoic acid 4-hydroxylase activity 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0016868 intramolecular phosphotransferase activity 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0035374 chondroitin sulfate binding 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0042975 peroxisome proliferator activated receptor binding 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0043422 protein kinase B binding 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0050815 phosphoserine residue binding 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0051864 histone H3K36 demethylase activity 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0051880 G-quadruplex DNA binding 3/5871 10/18639 0.3 0.952427184466019 0.65622308631647 0.985410405026044 GO:0005092 GDP-dissociation inhibitor activity 5/5871 17/18639 0.294117647058824 0.933752141633352 0.661797902269488 0.991614305036288 GO:0045125 bioactive lipid receptor activity 5/5871 17/18639 0.294117647058824 0.933752141633352 0.661797902269488 0.991614305036288 GO:0015020 glucuronosyltransferase activity 10/5871 34/18639 0.294117647058824 0.933752141633352 0.66543150427669 0.995972643655961 GO:0004536 DNA nuclease activity 19/5871 64/18639 0.296875 0.942506067961165 0.667605567217626 0.998139335535385 GO:0005540 hyaluronic acid binding 7/5871 24/18639 0.291666666666667 0.925970873786408 0.670950683352781 0.999876614887983 GO:0043998 histone H2A acetyltransferase activity 7/5871 24/18639 0.291666666666667 0.925970873786408 0.670950683352781 0.999876614887983 GO:0140033 acetylation-dependent protein binding 7/5871 24/18639 0.291666666666667 0.925970873786408 0.670950683352781 0.999876614887983 GO:0017018 myosin phosphatase activity 25/5871 84/18639 0.297619047619048 0.944868238557559 0.673385863322171 1 GO:0030544 Hsp70 protein binding 15/5871 51/18639 0.294117647058824 0.933752141633352 0.676123546959662 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 12/5871 41/18639 0.292682926829268 0.92919725313758 0.676843599509366 1 GO:0017080 sodium channel regulator activity 12/5871 41/18639 0.292682926829268 0.92919725313758 0.676843599509366 1 GO:0140828 metal cation:monoatomic cation antiporter activity 12/5871 41/18639 0.292682926829268 0.92919725313758 0.676843599509366 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 9/5871 31/18639 0.290322580645161 0.921703726902599 0.680679492018021 1 GO:0015101 organic cation transmembrane transporter activity 24/5871 81/18639 0.296296296296296 0.94066882416397 0.68116647576165 1 GO:0015085 calcium ion transmembrane transporter activity 44/5871 147/18639 0.299319727891156 0.950267485635031 0.688369553640703 1 GO:0051015 actin filament binding 63/5871 209/18639 0.301435406698565 0.956984252334278 0.688634404196514 1 GO:1990825 sequence-specific mRNA binding 4/5871 14/18639 0.285714285714286 0.907073509015257 0.689151265353372 1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 6/5871 21/18639 0.285714285714286 0.907073509015257 0.691562634619673 1 GO:0015174 basic amino acid transmembrane transporter activity 6/5871 21/18639 0.285714285714286 0.907073509015257 0.691562634619673 1 GO:0035613 RNA stem-loop binding 6/5871 21/18639 0.285714285714286 0.907073509015257 0.691562634619673 1 GO:0036122 BMP binding 6/5871 21/18639 0.285714285714286 0.907073509015257 0.691562634619673 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 6/5871 21/18639 0.285714285714286 0.907073509015257 0.691562634619673 1 GO:0070182 DNA polymerase binding 6/5871 21/18639 0.285714285714286 0.907073509015257 0.691562634619673 1 GO:0051119 sugar transmembrane transporter activity 8/5871 28/18639 0.285714285714286 0.907073509015257 0.697620501513702 1 GO:0051959 dynein light intermediate chain binding 8/5871 28/18639 0.285714285714286 0.907073509015257 0.697620501513702 1 GO:0141052 histone H3 demethylase activity 8/5871 28/18639 0.285714285714286 0.907073509015257 0.697620501513702 1 GO:0008234 cysteine-type peptidase activity 56/5871 187/18639 0.299465240641711 0.950729453299413 0.702393510660724 1 GO:0015179 L-amino acid transmembrane transporter activity 18/5871 62/18639 0.290322580645161 0.921703726902599 0.706556057136075 1 GO:0004520 DNA endonuclease activity 12/5871 42/18639 0.285714285714286 0.907073509015257 0.712364029646253 1 GO:0042056 chemoattractant activity 12/5871 42/18639 0.285714285714286 0.907073509015257 0.712364029646253 1 GO:0000900 mRNA regulatory element binding translation repressor activity 5/5871 18/18639 0.277777777777778 0.881877022653722 0.715786237556403 1 GO:0015172 acidic amino acid transmembrane transporter activity 5/5871 18/18639 0.277777777777778 0.881877022653722 0.715786237556403 1 GO:0017075 syntaxin-1 binding 5/5871 18/18639 0.277777777777778 0.881877022653722 0.715786237556403 1 GO:0015645 fatty acid ligase activity 7/5871 25/18639 0.28 0.888932038834951 0.716648539762234 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 7/5871 25/18639 0.28 0.888932038834951 0.716648539762234 1 GO:0042974 nuclear retinoic acid receptor binding 7/5871 25/18639 0.28 0.888932038834951 0.716648539762234 1 GO:0120515 fatty acid-CoA ligase activity 7/5871 25/18639 0.28 0.888932038834951 0.716648539762234 1 GO:0035254 glutamate receptor binding 14/5871 49/18639 0.285714285714286 0.907073509015257 0.719890533408528 1 GO:0060590 ATPase regulator activity 14/5871 49/18639 0.285714285714286 0.907073509015257 0.719890533408528 1 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0003953 NAD+ nucleosidase activity 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0008432 JUN kinase binding 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0015173 aromatic amino acid transmembrane transporter activity 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0016594 glycine binding 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0019203 carbohydrate phosphatase activity 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0019206 nucleoside kinase activity 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0042608 T cell receptor binding 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0043522 leucine zipper domain binding 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0047676 arachidonate-CoA ligase activity 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0070990 snRNP binding 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0140031 phosphorylation-dependent protein binding 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0140537 transcription regulator activator activity 3/5871 11/18639 0.272727272727273 0.865842894969108 0.724424013104608 1 GO:0044325 transmembrane transporter binding 40/5871 136/18639 0.294117647058824 0.933752141633352 0.729468002706434 1 GO:0005507 copper ion binding 18/5871 63/18639 0.285714285714286 0.907073509015257 0.734433469558779 1 GO:0005544 calcium-dependent phospholipid binding 15/5871 53/18639 0.283018867924528 0.898516211760396 0.738414058787041 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 15/5871 53/18639 0.283018867924528 0.898516211760396 0.738414058787041 1 GO:0004033 aldo-keto reductase (NADPH) activity 10/5871 36/18639 0.277777777777778 0.881877022653722 0.741159325544476 1 GO:0004190 aspartic-type endopeptidase activity 10/5871 36/18639 0.277777777777778 0.881877022653722 0.741159325544476 1 GO:0045505 dynein intermediate chain binding 10/5871 36/18639 0.277777777777778 0.881877022653722 0.741159325544476 1 GO:0004175 endopeptidase activity 122/5871 405/18639 0.301234567901235 0.956346637900036 0.743012365935613 1 GO:0004129 cytochrome-c oxidase activity 4/5871 15/18639 0.266666666666667 0.846601941747573 0.745010391474973 1 GO:0005523 tropomyosin binding 4/5871 15/18639 0.266666666666667 0.846601941747573 0.745010391474973 1 GO:0010181 FMN binding 4/5871 15/18639 0.266666666666667 0.846601941747573 0.745010391474973 1 GO:0061578 K63-linked deubiquitinase activity 4/5871 15/18639 0.266666666666667 0.846601941747573 0.745010391474973 1 GO:0008200 ion channel inhibitor activity 12/5871 43/18639 0.27906976744186 0.88597877624746 0.745326835026785 1 GO:0019783 ubiquitin-like protein peptidase activity 37/5871 127/18639 0.291338582677165 0.924929286751777 0.746908881047479 1 GO:0042277 peptide binding 74/5871 249/18639 0.29718875502008 0.943502163995789 0.749430526267672 1 GO:0019239 deaminase activity 9/5871 33/18639 0.272727272727273 0.865842894969108 0.757377550246187 1 GO:0140416 transcription regulator inhibitor activity 9/5871 33/18639 0.272727272727273 0.865842894969108 0.757377550246187 1 GO:0004529 DNA exonuclease activity 7/5871 26/18639 0.269230769230769 0.854742345033607 0.757834833413626 1 GO:0015145 monosaccharide transmembrane transporter activity 7/5871 26/18639 0.269230769230769 0.854742345033607 0.757834833413626 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/5871 19/18639 0.263157894736842 0.835462442514052 0.763333100539528 1 GO:0008381 mechanosensitive monoatomic ion channel activity 5/5871 19/18639 0.263157894736842 0.835462442514052 0.763333100539528 1 GO:0008574 plus-end-directed microtubule motor activity 5/5871 19/18639 0.263157894736842 0.835462442514052 0.763333100539528 1 GO:0022840 leak channel activity 5/5871 19/18639 0.263157894736842 0.835462442514052 0.763333100539528 1 GO:0022842 narrow pore channel activity 5/5871 19/18639 0.263157894736842 0.835462442514052 0.763333100539528 1 GO:0030506 ankyrin binding 5/5871 19/18639 0.263157894736842 0.835462442514052 0.763333100539528 1 GO:0070001 aspartic-type peptidase activity 10/5871 37/18639 0.27027027027027 0.858042508527945 0.774336661134377 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 8/5871 30/18639 0.266666666666667 0.846601941747573 0.775075278151151 1 GO:0001046 core promoter sequence-specific DNA binding 12/5871 44/18639 0.272727272727273 0.865842894969108 0.775665066100788 1 GO:0016248 channel inhibitor activity 12/5871 44/18639 0.272727272727273 0.865842894969108 0.775665066100788 1 GO:0001664 G protein-coupled receptor binding 88/5871 297/18639 0.296296296296296 0.94066882416397 0.775975747892175 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 6/5871 23/18639 0.260869565217391 0.828197551709582 0.779731450240502 1 GO:0004602 glutathione peroxidase activity 6/5871 23/18639 0.260869565217391 0.828197551709582 0.779731450240502 1 GO:0003720 telomerase activity 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0004032 aldose reductase (NADPH) activity 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0015132 prostaglandin transmembrane transporter activity 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0035197 siRNA binding 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0042301 phosphate ion binding 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0070008 serine-type exopeptidase activity 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0070679 inositol 1,4,5 trisphosphate binding 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0140900 chloride:bicarbonate antiporter activity 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:1990817 poly(A) RNA polymerase activity 3/5871 12/18639 0.25 0.793689320388349 0.781522539122688 1 GO:0003688 DNA replication origin binding 4/5871 16/18639 0.25 0.793689320388349 0.792838118596783 1 GO:0005149 interleukin-1 receptor binding 4/5871 16/18639 0.25 0.793689320388349 0.792838118596783 1 GO:0008296 3'-5'-DNA exonuclease activity 4/5871 16/18639 0.25 0.793689320388349 0.792838118596783 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/5871 16/18639 0.25 0.793689320388349 0.792838118596783 1 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/5871 16/18639 0.25 0.793689320388349 0.792838118596783 1 GO:0001671 ATPase activator activity 7/5871 27/18639 0.259259259259259 0.823085221143473 0.79450862458593 1 GO:0016405 CoA-ligase activity 7/5871 27/18639 0.259259259259259 0.823085221143473 0.79450862458593 1 GO:0099106 ion channel regulator activity 46/5871 160/18639 0.2875 0.912742718446602 0.797842912271778 1 GO:0031406 carboxylic acid binding 54/5871 187/18639 0.288770053475936 0.916774829967291 0.802924256609493 1 GO:0141110 transporter inhibitor activity 12/5871 45/18639 0.266666666666667 0.846601941747573 0.803370557609868 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 5/5871 20/18639 0.25 0.793689320388349 0.80458566451822 1 GO:0016408 C-acyltransferase activity 5/5871 20/18639 0.25 0.793689320388349 0.80458566451822 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 16/5871 59/18639 0.271186440677966 0.860951127200921 0.80543576749912 1 GO:0005452 solute:inorganic anion antiporter activity 8/5871 31/18639 0.258064516129032 0.8192922016912 0.807908595067023 1 GO:0047499 calcium-independent phospholipase A2 activity 8/5871 31/18639 0.258064516129032 0.8192922016912 0.807908595067023 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 6/5871 24/18639 0.25 0.793689320388349 0.815991705869742 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 6/5871 24/18639 0.25 0.793689320388349 0.815991705869742 1 GO:0004806 triacylglycerol lipase activity 6/5871 24/18639 0.25 0.793689320388349 0.815991705869742 1 GO:0005315 phosphate transmembrane transporter activity 6/5871 24/18639 0.25 0.793689320388349 0.815991705869742 1 GO:0015149 hexose transmembrane transporter activity 6/5871 24/18639 0.25 0.793689320388349 0.815991705869742 1 GO:0030552 cAMP binding 6/5871 24/18639 0.25 0.793689320388349 0.815991705869742 1 GO:0050699 WW domain binding 6/5871 24/18639 0.25 0.793689320388349 0.815991705869742 1 GO:0055056 D-glucose transmembrane transporter activity 6/5871 24/18639 0.25 0.793689320388349 0.815991705869742 1 GO:0004857 enzyme inhibitor activity 123/5871 416/18639 0.295673076923077 0.938690253920836 0.81855740228054 1 GO:0140566 histone reader activity 9/5871 35/18639 0.257142857142857 0.816366158113731 0.820125289461943 1 GO:0051393 alpha-actinin binding 7/5871 28/18639 0.25 0.793689320388349 0.826804665610006 1 GO:0046906 tetrapyrrole binding 43/5871 152/18639 0.282894736842105 0.898122125702606 0.826838252738054 1 GO:0003964 RNA-directed DNA polymerase activity 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0004535 poly(A)-specific ribonuclease activity 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0005542 folic acid binding 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0046974 histone H3K9 methyltransferase activity 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0061459 L-arginine transmembrane transporter activity 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0070700 BMP receptor binding 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0071837 HMG box domain binding 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0089720 caspase binding 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0097157 pre-mRNA intronic binding 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0140666 annealing activity 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:1901338 catecholamine binding 3/5871 13/18639 0.230769230769231 0.732636295743092 0.828455706683627 1 GO:0016500 protein-hormone receptor activity 18/5871 67/18639 0.26865671641791 0.852919866685988 0.828455750862799 1 GO:0043177 organic acid binding 54/5871 189/18639 0.285714285714286 0.907073509015257 0.828569192922077 1 GO:0000217 DNA secondary structure binding 10/5871 39/18639 0.256410256410256 0.814040328603435 0.831314165329337 1 GO:0070492 oligosaccharide binding 4/5871 17/18639 0.235294117647059 0.747001713306682 0.833158185159028 1 GO:0047498 calcium-dependent phospholipase A2 activity 8/5871 32/18639 0.25 0.793689320388349 0.83695586717865 1 GO:0004601 peroxidase activity 15/5871 57/18639 0.263157894736842 0.835462442514052 0.8379927210589 1 GO:0005123 death receptor binding 5/5871 21/18639 0.238095238095238 0.755894590846047 0.839905361361517 1 GO:0009931 calcium-dependent protein serine/threonine kinase activity 5/5871 21/18639 0.238095238095238 0.755894590846047 0.839905361361517 1 GO:0061891 calcium ion sensor activity 5/5871 21/18639 0.238095238095238 0.755894590846047 0.839905361361517 1 GO:0141108 transporter regulator activity 48/5871 170/18639 0.282352941176471 0.896402055968018 0.842139448190508 1 GO:0017056 structural constituent of nuclear pore 6/5871 25/18639 0.24 0.761941747572816 0.847363232008955 1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 7/5871 29/18639 0.241379310344828 0.766320723133579 0.854957551191234 1 GO:0097472 cyclin-dependent protein kinase activity 7/5871 29/18639 0.241379310344828 0.766320723133579 0.854957551191234 1 GO:0106222 lncRNA binding 7/5871 29/18639 0.241379310344828 0.766320723133579 0.854957551191234 1 GO:0016247 channel regulator activity 47/5871 168/18639 0.279761904761905 0.888176144244105 0.858247279646309 1 GO:0019956 chemokine binding 8/5871 33/18639 0.242424242424242 0.76963812886143 0.862420928597039 1 GO:0008392 arachidonate epoxygenase activity 3/5871 14/18639 0.214285714285714 0.680305131761442 0.866447827046424 1 GO:0008494 translation activator activity 3/5871 14/18639 0.214285714285714 0.680305131761442 0.866447827046424 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 3/5871 14/18639 0.214285714285714 0.680305131761442 0.866447827046424 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/5871 14/18639 0.214285714285714 0.680305131761442 0.866447827046424 1 GO:0044548 S100 protein binding 3/5871 14/18639 0.214285714285714 0.680305131761442 0.866447827046424 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/5871 14/18639 0.214285714285714 0.680305131761442 0.866447827046424 1 GO:0000400 four-way junction DNA binding 4/5871 18/18639 0.222222222222222 0.705501618122977 0.866693027331207 1 GO:0004970 glutamate-gated receptor activity 4/5871 18/18639 0.222222222222222 0.705501618122977 0.866693027331207 1 GO:0050811 GABA receptor binding 4/5871 18/18639 0.222222222222222 0.705501618122977 0.866693027331207 1 GO:0098641 cadherin binding involved in cell-cell adhesion 4/5871 18/18639 0.222222222222222 0.705501618122977 0.866693027331207 1 GO:0022829 wide pore channel activity 9/5871 37/18639 0.243243243243243 0.772238257675151 0.869625689816593 1 GO:0042805 actinin binding 9/5871 37/18639 0.243243243243243 0.772238257675151 0.869625689816593 1 GO:0008970 phospholipase A1 activity 5/5871 22/18639 0.227272727272727 0.72153574580759 0.869788941000006 1 GO:0070034 telomerase RNA binding 5/5871 22/18639 0.227272727272727 0.72153574580759 0.869788941000006 1 GO:0140784 metal ion sensor activity 5/5871 22/18639 0.227272727272727 0.72153574580759 0.869788941000006 1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 12/5871 48/18639 0.25 0.793689320388349 0.871304480985035 1 GO:0020037 heme binding 39/5871 142/18639 0.274647887323944 0.871940380144947 0.871381742426691 1 GO:0004935 adrenergic receptor activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0015203 polyamine transmembrane transporter activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0019531 oxalate transmembrane transporter activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0032052 bile acid binding 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0043121 neurotrophin binding 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0045322 unmethylated CpG binding 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0050308 sugar-phosphatase activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0051378 serotonin binding 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0070513 death domain binding 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/5871 10/18639 0.2 0.63495145631068 0.87270205464774 1 GO:0015291 secondary active transmembrane transporter activity 82/5871 287/18639 0.285714285714286 0.907073509015257 0.873357440542235 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 6/5871 26/18639 0.230769230769231 0.732636295743092 0.874221751587554 1 GO:0005227 calcium-activated cation channel activity 6/5871 26/18639 0.230769230769231 0.732636295743092 0.874221751587554 1 GO:0008157 protein phosphatase 1 binding 6/5871 26/18639 0.230769230769231 0.732636295743092 0.874221751587554 1 GO:0042169 SH2 domain binding 10/5871 41/18639 0.24390243902439 0.774331044281317 0.876513046084423 1 GO:0042287 MHC protein binding 10/5871 41/18639 0.24390243902439 0.774331044281317 0.876513046084423 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 13/5871 52/18639 0.25 0.793689320388349 0.878522561370817 1 GO:0022839 monoatomic ion-gated channel activity 7/5871 30/18639 0.233333333333333 0.740776699029126 0.879269547333867 1 GO:0003774 cytoskeletal motor activity 42/5871 153/18639 0.274509803921569 0.871501998857796 0.879821195641575 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 11/5871 45/18639 0.244444444444444 0.776051779935275 0.883060000224632 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 8/5871 34/18639 0.235294117647059 0.747001713306682 0.884557175305295 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 8/5871 34/18639 0.235294117647059 0.747001713306682 0.884557175305295 1 GO:0015171 amino acid transmembrane transporter activity 27/5871 102/18639 0.264705882352941 0.840376927470017 0.886840670051066 1 GO:0008301 DNA binding, bending 4/5871 19/18639 0.210526315789474 0.668369954011242 0.894255674475654 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 4/5871 19/18639 0.210526315789474 0.668369954011242 0.894255674475654 1 GO:0031681 G-protein beta-subunit binding 5/5871 23/18639 0.217391304347826 0.690164626424652 0.894804910655425 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/5871 23/18639 0.217391304347826 0.690164626424652 0.894804910655425 1 GO:0035198 miRNA binding 10/5871 42/18639 0.238095238095238 0.755894590846047 0.895119271802529 1 GO:0008146 sulfotransferase activity 13/5871 53/18639 0.245283018867925 0.778714050192343 0.89512781867359 1 GO:0004089 carbonate dehydratase activity 3/5871 15/18639 0.2 0.63495145631068 0.896807185939286 1 GO:0004467 long-chain fatty acid-CoA ligase activity 3/5871 15/18639 0.2 0.63495145631068 0.896807185939286 1 GO:0015116 sulfate transmembrane transporter activity 3/5871 15/18639 0.2 0.63495145631068 0.896807185939286 1 GO:0017081 chloride channel regulator activity 3/5871 15/18639 0.2 0.63495145631068 0.896807185939286 1 GO:0034483 heparan sulfate sulfotransferase activity 3/5871 15/18639 0.2 0.63495145631068 0.896807185939286 1 GO:0045504 dynein heavy chain binding 3/5871 15/18639 0.2 0.63495145631068 0.896807185939286 1 GO:0050700 CARD domain binding 3/5871 15/18639 0.2 0.63495145631068 0.896807185939286 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/5871 15/18639 0.2 0.63495145631068 0.896807185939286 1 GO:0140776 protein-containing complex destabilizing activity 3/5871 15/18639 0.2 0.63495145631068 0.896807185939286 1 GO:0008395 steroid hydroxylase activity 6/5871 27/18639 0.222222222222222 0.705501618122977 0.896996930730874 1 GO:0035255 ionotropic glutamate receptor binding 6/5871 27/18639 0.222222222222222 0.705501618122977 0.896996930730874 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 11/5871 46/18639 0.239130434782609 0.759181089067117 0.900212106103365 1 GO:0008083 growth factor activity 44/5871 162/18639 0.271604938271605 0.862279755483639 0.900812130770971 1 GO:0004623 phospholipase A2 activity 8/5871 35/18639 0.228571428571429 0.725658807212205 0.903648104444066 1 GO:0005154 epidermal growth factor receptor binding 8/5871 35/18639 0.228571428571429 0.725658807212205 0.903648104444066 1 GO:0001851 complement component C3b binding 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0004954 prostanoid receptor activity 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0008046 axon guidance receptor activity 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0008271 secondary active sulfate transmembrane transporter activity 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0019215 intermediate filament binding 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0019864 IgG binding 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0050786 RAGE receptor binding 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0050998 nitric-oxide synthase binding 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0070697 activin receptor binding 2/5871 11/18639 0.181818181818182 0.577228596646072 0.905652730546214 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 5/5871 24/18639 0.208333333333333 0.661407766990291 0.915545227704289 1 GO:0048027 mRNA 5'-UTR binding 5/5871 24/18639 0.208333333333333 0.661407766990291 0.915545227704289 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 5/5871 24/18639 0.208333333333333 0.661407766990291 0.915545227704289 1 GO:0001614 purinergic nucleotide receptor activity 4/5871 20/18639 0.2 0.63495145631068 0.916673176965013 1 GO:0016502 nucleotide receptor activity 4/5871 20/18639 0.2 0.63495145631068 0.916673176965013 1 GO:0016505 peptidase activator activity involved in apoptotic process 4/5871 20/18639 0.2 0.63495145631068 0.916673176965013 1 GO:0005272 sodium channel activity 12/5871 51/18639 0.235294117647059 0.747001713306682 0.919044298801286 1 GO:0008391 arachidonate monooxygenase activity 3/5871 16/18639 0.1875 0.595266990291262 0.920800047633709 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 3/5871 16/18639 0.1875 0.595266990291262 0.920800047633709 1 GO:0022832 voltage-gated channel activity 47/5871 175/18639 0.268571428571429 0.852649098474341 0.922321584117816 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 9/5871 40/18639 0.225 0.714320388349515 0.922585870430442 1 GO:0030547 signaling receptor inhibitor activity 10/5871 44/18639 0.227272727272727 0.72153574580759 0.925382770266985 1 GO:0070888 E-box binding 14/5871 59/18639 0.23728813559322 0.753332236300806 0.926376840999834 1 GO:0015166 polyol transmembrane transporter activity 2/5871 12/18639 0.166666666666667 0.529126213592233 0.930478768830919 1 GO:0015269 calcium-activated potassium channel activity 2/5871 12/18639 0.166666666666667 0.529126213592233 0.930478768830919 1 GO:0035259 nuclear glucocorticoid receptor binding 2/5871 12/18639 0.166666666666667 0.529126213592233 0.930478768830919 1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/5871 12/18639 0.166666666666667 0.529126213592233 0.930478768830919 1 GO:0097371 MDM2/MDM4 family protein binding 2/5871 12/18639 0.166666666666667 0.529126213592233 0.930478768830919 1 GO:0097677 STAT family protein binding 2/5871 12/18639 0.166666666666667 0.529126213592233 0.930478768830919 1 GO:0005416 amino acid:monoatomic cation symporter activity 6/5871 29/18639 0.206896551724138 0.656846334114496 0.93210098652191 1 GO:0005244 voltage-gated monoatomic ion channel activity 46/5871 173/18639 0.265895953757225 0.844155115326337 0.932165776869074 1 GO:0005253 monoatomic anion channel activity 26/5871 103/18639 0.252427184466019 0.801395041945518 0.932547711511176 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 5/5871 25/18639 0.2 0.63495145631068 0.932590726628122 1 GO:0047617 fatty acyl-CoA hydrolase activity 5/5871 25/18639 0.2 0.63495145631068 0.932590726628122 1 GO:0008514 organic anion transmembrane transporter activity 74/5871 269/18639 0.275092936802974 0.87335330421915 0.932604662093315 1 GO:0030296 protein tyrosine kinase activator activity 7/5871 33/18639 0.212121212121212 0.673433362753751 0.932657457630773 1 GO:0170055 lipid transmembrane transporter activity 13/5871 56/18639 0.232142857142857 0.736997226074896 0.934106362540654 1 GO:0001846 opsonin binding 4/5871 21/18639 0.19047619047619 0.604715672676838 0.934736192401129 1 GO:0005248 voltage-gated sodium channel activity 4/5871 21/18639 0.19047619047619 0.604715672676838 0.934736192401129 1 GO:0015125 bile acid transmembrane transporter activity 4/5871 21/18639 0.19047619047619 0.604715672676838 0.934736192401129 1 GO:0051428 peptide hormone receptor binding 4/5871 21/18639 0.19047619047619 0.604715672676838 0.934736192401129 1 GO:0008009 chemokine activity 10/5871 45/18639 0.222222222222222 0.705501618122977 0.937474990279086 1 GO:0070851 growth factor receptor binding 36/5871 139/18639 0.258992805755396 0.822239295941887 0.937596617058054 1 GO:0008569 minus-end-directed microtubule motor activity 3/5871 17/18639 0.176470588235294 0.560251284980011 0.939580446735427 1 GO:0016805 dipeptidase activity 3/5871 17/18639 0.176470588235294 0.560251284980011 0.939580446735427 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/5871 17/18639 0.176470588235294 0.560251284980011 0.939580446735427 1 GO:0045236 CXCR chemokine receptor binding 3/5871 17/18639 0.176470588235294 0.560251284980011 0.939580446735427 1 GO:1990226 histone methyltransferase binding 3/5871 17/18639 0.176470588235294 0.560251284980011 0.939580446735427 1 GO:0003777 microtubule motor activity 16/5871 68/18639 0.235294117647059 0.747001713306682 0.942454395544006 1 GO:0003735 structural constituent of ribosome 46/5871 175/18639 0.262857142857143 0.834507628294036 0.944078666285798 1 GO:0005254 chloride channel activity 20/5871 83/18639 0.240963855421687 0.76500175459118 0.945129487463193 1 GO:0033612 receptor serine/threonine kinase binding 6/5871 30/18639 0.2 0.63495145631068 0.94530884631892 1 GO:0048019 receptor antagonist activity 6/5871 30/18639 0.2 0.63495145631068 0.94530884631892 1 GO:0016289 acyl-CoA hydrolase activity 5/5871 26/18639 0.192307692307692 0.610530246452577 0.946488101637781 1 GO:0008307 structural constituent of muscle 9/5871 42/18639 0.214285714285714 0.680305131761442 0.946568737861913 1 GO:0015103 inorganic anion transmembrane transporter activity 43/5871 165/18639 0.260606060606061 0.827360988526037 0.946591751285782 1 GO:0004993 G protein-coupled serotonin receptor activity 2/5871 13/18639 0.153846153846154 0.488424197162061 0.949028416494063 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/5871 13/18639 0.153846153846154 0.488424197162061 0.949028416494063 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/5871 13/18639 0.153846153846154 0.488424197162061 0.949028416494063 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/5871 13/18639 0.153846153846154 0.488424197162061 0.949028416494063 1 GO:0140463 chromatin-protein adaptor activity 12/5871 54/18639 0.222222222222222 0.705501618122977 0.950881954049997 1 GO:0061980 regulatory RNA binding 13/5871 58/18639 0.224137931034483 0.711583528624038 0.952555217329583 1 GO:0017171 serine hydrolase activity 52/5871 198/18639 0.262626262626263 0.833774639599882 0.954526976586191 1 GO:0031490 chromatin DNA binding 32/5871 128/18639 0.25 0.793689320388349 0.956255812973764 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 16/5871 70/18639 0.228571428571429 0.725658807212205 0.95771836185655 1 GO:0022843 voltage-gated monoatomic cation channel activity 36/5871 143/18639 0.251748251748252 0.7992395953561 0.959935189376592 1 GO:0015459 potassium channel regulator activity 13/5871 59/18639 0.220338983050847 0.699522790850749 0.959953454118425 1 GO:0005212 structural constituent of eye lens 4/5871 23/18639 0.173913043478261 0.552131701139721 0.960613968467194 1 GO:0005283 amino acid:sodium symporter activity 4/5871 23/18639 0.173913043478261 0.552131701139721 0.960613968467194 1 GO:0016917 GABA receptor activity 4/5871 23/18639 0.173913043478261 0.552131701139721 0.960613968467194 1 GO:0005344 oxygen carrier activity 2/5871 14/18639 0.142857142857143 0.453536754507628 0.96279184806867 1 GO:0019763 immunoglobulin receptor activity 2/5871 14/18639 0.142857142857143 0.453536754507628 0.96279184806867 1 GO:0043176 amine binding 2/5871 14/18639 0.142857142857143 0.453536754507628 0.96279184806867 1 GO:0015144 carbohydrate transmembrane transporter activity 8/5871 40/18639 0.2 0.63495145631068 0.963692045490695 1 GO:0004252 serine-type endopeptidase activity 45/5871 176/18639 0.255681818181818 0.811727714033539 0.964707150611489 1 GO:0015106 bicarbonate transmembrane transporter activity 6/5871 32/18639 0.1875 0.595266990291262 0.965025521753509 1 GO:0043425 bHLH transcription factor binding 6/5871 32/18639 0.1875 0.595266990291262 0.965025521753509 1 GO:0016918 retinal binding 3/5871 19/18639 0.157894736842105 0.501277465508431 0.965389603642637 1 GO:0042834 peptidoglycan binding 3/5871 19/18639 0.157894736842105 0.501277465508431 0.965389603642637 1 GO:0008236 serine-type peptidase activity 50/5871 194/18639 0.257731958762887 0.818236412771494 0.966202754735678 1 GO:0033293 monocarboxylic acid binding 18/5871 79/18639 0.227848101265823 0.723362418581787 0.966612748279655 1 GO:0030551 cyclic nucleotide binding 7/5871 37/18639 0.189189189189189 0.600629755969562 0.971111189474488 1 GO:0004497 monooxygenase activity 25/5871 106/18639 0.235849056603774 0.74876350980033 0.971436426006833 1 GO:0004953 icosanoid receptor activity 2/5871 15/18639 0.133333333333333 0.423300970873786 0.972943334550114 1 GO:0008252 nucleotidase activity 2/5871 15/18639 0.133333333333333 0.423300970873786 0.972943334550114 1 GO:0140161 monocarboxylate:sodium symporter activity 2/5871 15/18639 0.133333333333333 0.423300970873786 0.972943334550114 1 GO:0001972 retinoic acid binding 3/5871 20/18639 0.15 0.47621359223301 0.973986620115159 1 GO:0004181 metallocarboxypeptidase activity 5/5871 29/18639 0.172413793103448 0.547371945095414 0.97400318066142 1 GO:0048020 CCR chemokine receptor binding 10/5871 50/18639 0.2 0.63495145631068 0.975666512460672 1 GO:0031492 nucleosomal DNA binding 8/5871 42/18639 0.19047619047619 0.604715672676838 0.976150464504549 1 GO:0001848 complement binding 4/5871 25/18639 0.16 0.507961165048544 0.97668238138009 1 GO:0005251 delayed rectifier potassium channel activity 4/5871 25/18639 0.16 0.507961165048544 0.97668238138009 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/5871 25/18639 0.16 0.507961165048544 0.97668238138009 1 GO:0000146 microfilament motor activity 7/5871 38/18639 0.184210526315789 0.584823709759836 0.976867245392995 1 GO:0005501 retinoid binding 7/5871 38/18639 0.184210526315789 0.584823709759836 0.976867245392995 1 GO:0019840 isoprenoid binding 7/5871 38/18639 0.184210526315789 0.584823709759836 0.976867245392995 1 GO:0004955 prostaglandin receptor activity 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0005337 nucleoside transmembrane transporter activity 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0005345 purine nucleobase transmembrane transporter activity 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0008519 ammonium channel activity 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0019911 structural constituent of myelin sheath 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0031720 haptoglobin binding 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0031996 thioesterase binding 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0140999 histone H3K4 trimethyltransferase activity 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:1990763 arrestin family protein binding 1/5871 10/18639 0.1 0.31747572815534 0.977274140050239 1 GO:0031491 nucleosome binding 16/5871 74/18639 0.216216216216216 0.686434006822356 0.977988355649948 1 GO:0061135 endopeptidase regulator activity 46/5871 184/18639 0.25 0.793689320388349 0.978311635324084 1 GO:0046943 carboxylic acid transmembrane transporter activity 47/5871 188/18639 0.25 0.793689320388349 0.979352585103549 1 GO:0016597 amino acid binding 10/5871 51/18639 0.196078431372549 0.622501427755568 0.980071771573164 1 GO:0099095 ligand-gated monoatomic anion channel activity 9/5871 47/18639 0.191489361702128 0.607932245403842 0.980308388989226 1 GO:0019841 retinol binding 2/5871 16/18639 0.125 0.396844660194175 0.980392375538171 1 GO:0055102 lipase inhibitor activity 2/5871 16/18639 0.125 0.396844660194175 0.980392375538171 1 GO:0005342 organic acid transmembrane transporter activity 47/5871 189/18639 0.248677248677249 0.78948990599476 0.981550078021747 1 GO:0008066 glutamate receptor activity 4/5871 26/18639 0.153846153846154 0.488424197162061 0.982172250424146 1 GO:0005343 organic acid:sodium symporter activity 6/5871 35/18639 0.171428571428571 0.544244105409154 0.98268402402145 1 GO:0015108 chloride transmembrane transporter activity 28/5871 121/18639 0.231404958677686 0.734654577549547 0.983528391475214 1 GO:0038187 pattern recognition receptor activity 9/5871 48/18639 0.1875 0.595266990291262 0.984048533604331 1 GO:0061134 peptidase regulator activity 57/5871 226/18639 0.252212389380531 0.800713119683822 0.984260139309267 1 GO:0005164 tumor necrosis factor receptor binding 5/5871 31/18639 0.161290322580645 0.512057626057 0.984276477551702 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0008199 ferric iron binding 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0008503 benzodiazepine receptor activity 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0015205 nucleobase transmembrane transporter activity 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:1990948 ubiquitin ligase inhibitor activity 1/5871 11/18639 0.0909090909090909 0.288614298323036 0.984436281000641 1 GO:0005243 gap junction channel activity 3/5871 22/18639 0.136363636363636 0.432921447484554 0.985479849088463 1 GO:0015377 chloride:monoatomic cation symporter activity 3/5871 22/18639 0.136363636363636 0.432921447484554 0.985479849088463 1 GO:0033691 sialic acid binding 3/5871 22/18639 0.136363636363636 0.432921447484554 0.985479849088463 1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/5871 17/18639 0.117647058823529 0.373500856653341 0.985833966045204 1 GO:0009881 photoreceptor activity 2/5871 17/18639 0.117647058823529 0.373500856653341 0.985833966045204 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/5871 17/18639 0.117647058823529 0.373500856653341 0.985833966045204 1 GO:0016018 cyclosporin A binding 2/5871 17/18639 0.117647058823529 0.373500856653341 0.985833966045204 1 GO:0036041 long-chain fatty acid binding 2/5871 17/18639 0.117647058823529 0.373500856653341 0.985833966045204 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 131/5871 484/18639 0.270661157024793 0.85928347909813 0.986117596460216 1 GO:0005104 fibroblast growth factor receptor binding 4/5871 27/18639 0.148148148148148 0.470334412081985 0.986422016580395 1 GO:0023026 MHC class II protein complex binding 4/5871 27/18639 0.148148148148148 0.470334412081985 0.986422016580395 1 GO:0008509 monoatomic anion transmembrane transporter activity 35/5871 149/18639 0.23489932885906 0.745748354727308 0.987823894046962 1 GO:0001530 lipopolysaccharide binding 7/5871 41/18639 0.170731707317073 0.542031730996922 0.988386341431312 1 GO:0099186 structural constituent of postsynapse 3/5871 23/18639 0.130434782608696 0.414098775854791 0.989209731181653 1 GO:0004859 phospholipase inhibitor activity 1/5871 12/18639 0.0833333333333333 0.264563106796116 0.989341509379707 1 GO:0004875 complement receptor activity 1/5871 12/18639 0.0833333333333333 0.264563106796116 0.989341509379707 1 GO:0015368 calcium:monoatomic cation antiporter activity 1/5871 12/18639 0.0833333333333333 0.264563106796116 0.989341509379707 1 GO:0001216 DNA-binding transcription activator activity 132/5871 491/18639 0.268839103869654 0.853498902576474 0.98947034682046 1 GO:0032813 tumor necrosis factor receptor superfamily binding 9/5871 50/18639 0.18 0.571456310679612 0.989636038499928 1 GO:0005242 inward rectifier potassium channel activity 4/5871 28/18639 0.142857142857143 0.453536754507628 0.989695908605382 1 GO:0022851 GABA-gated chloride ion channel activity 2/5871 18/18639 0.111111111111111 0.352750809061489 0.98979347047382 1 GO:0032393 MHC class I receptor activity 2/5871 18/18639 0.111111111111111 0.352750809061489 0.98979347047382 1 GO:0004180 carboxypeptidase activity 8/5871 46/18639 0.173913043478261 0.552131701139721 0.990149890430565 1 GO:0098632 cell-cell adhesion mediator activity 10/5871 55/18639 0.181818181818182 0.577228596646072 0.991322431107062 1 GO:0004867 serine-type endopeptidase inhibitor activity 20/5871 95/18639 0.210526315789474 0.668369954011242 0.991428376994463 1 GO:0019957 C-C chemokine binding 3/5871 24/18639 0.125 0.396844660194175 0.99200716183335 1 GO:0005504 fatty acid binding 8/5871 47/18639 0.170212765957447 0.540384218136749 0.992168659956994 1 GO:0098631 cell adhesion mediator activity 15/5871 76/18639 0.197368421052632 0.626596831885539 0.992364019628872 1 GO:0004890 GABA-A receptor activity 2/5871 19/18639 0.105263157894737 0.334184977005621 0.99266451363043 1 GO:0034987 immunoglobulin receptor binding 2/5871 19/18639 0.105263157894737 0.334184977005621 0.99266451363043 1 GO:0099589 serotonin receptor activity 2/5871 19/18639 0.105263157894737 0.334184977005621 0.99266451363043 1 GO:0004465 lipoprotein lipase activity 1/5871 13/18639 0.0769230769230769 0.244212098581031 0.992700933786844 1 GO:0008253 5'-nucleotidase activity 1/5871 13/18639 0.0769230769230769 0.244212098581031 0.992700933786844 1 GO:0032396 inhibitory MHC class I receptor activity 1/5871 13/18639 0.0769230769230769 0.244212098581031 0.992700933786844 1 GO:0035325 Toll-like receptor binding 1/5871 13/18639 0.0769230769230769 0.244212098581031 0.992700933786844 1 GO:0004896 cytokine receptor activity 20/5871 96/18639 0.208333333333333 0.661407766990291 0.992770578290174 1 GO:0019825 oxygen binding 5/5871 34/18639 0.147058823529412 0.466876070816676 0.992805050740778 1 GO:0005200 structural constituent of cytoskeleton 24/5871 112/18639 0.214285714285714 0.680305131761442 0.993408993708613 1 GO:0004866 endopeptidase inhibitor activity 37/5871 161/18639 0.229813664596273 0.729602605077489 0.993490583792128 1 GO:0015294 solute:monoatomic cation symporter activity 25/5871 116/18639 0.21551724137931 0.684214931369267 0.993587249428359 1 GO:0005267 potassium channel activity 27/5871 124/18639 0.217741935483871 0.69127779517695 0.993953248466679 1 GO:0030414 peptidase inhibitor activity 39/5871 169/18639 0.230769230769231 0.732636295743092 0.994002400625803 1 GO:0098918 structural constituent of synapse 4/5871 30/18639 0.133333333333333 0.423300970873786 0.9941243908528 1 GO:0005326 neurotransmitter transmembrane transporter activity 2/5871 20/18639 0.1 0.31747572815534 0.994739835132127 1 GO:0005249 voltage-gated potassium channel activity 20/5871 98/18639 0.204081632653061 0.647909649296612 0.994890864906103 1 GO:0005261 monoatomic cation channel activity 86/5871 341/18639 0.252199413489736 0.800671924380036 0.995648242170666 1 GO:0015293 symporter activity 32/5871 146/18639 0.219178082191781 0.695837212395265 0.996198643605936 1 GO:0008020 G protein-coupled photoreceptor activity 1/5871 15/18639 0.0666666666666667 0.211650485436893 0.996577225412394 1 GO:0015250 water channel activity 1/5871 15/18639 0.0666666666666667 0.211650485436893 0.996577225412394 1 GO:0030553 cGMP binding 1/5871 15/18639 0.0666666666666667 0.211650485436893 0.996577225412394 1 GO:0042379 chemokine receptor binding 13/5871 72/18639 0.180555555555556 0.573220064724919 0.996648776291527 1 GO:0023023 MHC protein complex binding 5/5871 37/18639 0.135135135135135 0.429021254263973 0.996800290061944 1 GO:0015079 potassium ion transmembrane transporter activity 35/5871 160/18639 0.21875 0.694478155339806 0.997446826296557 1 GO:0015378 sodium:chloride symporter activity 1/5871 16/18639 0.0625 0.198422330097087 0.997656215404009 1 GO:0016493 C-C chemokine receptor activity 2/5871 23/18639 0.0869565217391304 0.276065850569861 0.998082958138885 1 GO:0051427 hormone receptor binding 4/5871 34/18639 0.117647058823529 0.373500856653341 0.998154226983977 1 GO:0046873 metal ion transmembrane transporter activity 114/5871 450/18639 0.253333333333333 0.804271844660194 0.998425677386254 1 GO:0005216 monoatomic ion channel activity 113/5871 448/18639 0.252232142857143 0.800775832177531 0.998647002339929 1 GO:0005372 water transmembrane transporter activity 1/5871 18/18639 0.0555555555555556 0.176375404530744 0.998901084548647 1 GO:0015373 monoatomic anion:sodium symporter activity 1/5871 18/18639 0.0555555555555556 0.176375404530744 0.998901084548647 1 GO:0008227 G protein-coupled amine receptor activity 5/5871 41/18639 0.121951219512195 0.387165522140658 0.998953747142332 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/5871 36/18639 0.111111111111111 0.352750809061489 0.998980650195295 1 GO:0005126 cytokine receptor binding 64/5871 275/18639 0.232727272727273 0.738852603706973 0.999035057188902 1 GO:0005184 neuropeptide hormone activity 3/5871 31/18639 0.0967741935483871 0.3072345756342 0.999090516617392 1 GO:0001637 G protein-coupled chemoattractant receptor activity 2/5871 26/18639 0.0769230769230769 0.244212098581031 0.999311417643537 1 GO:0004950 chemokine receptor activity 2/5871 26/18639 0.0769230769230769 0.244212098581031 0.999311417643537 1 GO:0019865 immunoglobulin binding 2/5871 26/18639 0.0769230769230769 0.244212098581031 0.999311417643537 1 GO:0160041 neuropeptide activity 3/5871 32/18639 0.09375 0.297633495145631 0.999338915995462 1 GO:0030627 pre-mRNA 5'-splice site binding 1/5871 20/18639 0.05 0.15873786407767 0.999484809425435 1 GO:0001653 peptide receptor activity 24/5871 128/18639 0.1875 0.595266990291262 0.999607232430289 1 GO:0071855 neuropeptide receptor binding 4/5871 40/18639 0.1 0.31747572815534 0.999696710580011 1 GO:0033038 bitter taste receptor activity 1/5871 22/18639 0.0454545454545455 0.144307149161518 0.999758493640312 1 GO:0140517 protein-RNA adaptor activity 1/5871 22/18639 0.0454545454545455 0.144307149161518 0.999758493640312 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/5871 36/18639 0.0833333333333333 0.264563106796116 0.999818501914135 1 GO:0008528 G protein-coupled peptide receptor activity 21/5871 122/18639 0.172131147540984 0.54647461403788 0.999890250048723 1 GO:0099094 ligand-gated monoatomic cation channel activity 24/5871 136/18639 0.176470588235294 0.560251284980011 0.99991790794863 1 GO:0042605 peptide antigen binding 4/5871 45/18639 0.0888888888888889 0.282200647249191 0.999935902246049 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6/5871 56/18639 0.107142857142857 0.340152565880721 0.999939493434016 1 GO:0022836 gated channel activity 70/5871 318/18639 0.220125786163522 0.698845942480308 0.999941043669333 1 GO:0046982 protein heterodimerization activity 83/5871 369/18639 0.224932249322493 0.71410529639277 0.999957456140265 1 GO:0022824 transmitter-gated monoatomic ion channel activity 7/5871 63/18639 0.111111111111111 0.352750809061489 0.999964407589756 1 GO:0022835 transmitter-gated channel activity 7/5871 63/18639 0.111111111111111 0.352750809061489 0.999964407589756 1 GO:0005125 cytokine activity 47/5871 234/18639 0.200854700854701 0.637664924072691 0.99996920030901 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 5/5871 53/18639 0.0943396226415094 0.299505403920132 0.99996987210479 1 GO:0036002 pre-mRNA binding 6/5871 59/18639 0.101694915254237 0.322856672700346 0.999974906993746 1 GO:0008527 taste receptor activity 1/5871 28/18639 0.0357142857142857 0.113384188626907 0.999975137050513 1 GO:0015081 sodium ion transmembrane transporter activity 29/5871 164/18639 0.176829268292683 0.561390007103954 0.999980477886444 1 GO:0015276 ligand-gated monoatomic ion channel activity 34/5871 186/18639 0.182795698924731 0.580331976197933 0.999985046299472 1 GO:0022834 ligand-gated channel activity 34/5871 188/18639 0.180851063829787 0.574158231770295 0.999989810068936 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 8/5871 73/18639 0.10958904109589 0.347918606197633 0.999991104110342 1 GO:0042923 neuropeptide binding 1/5871 33/18639 0.0303030303030303 0.0962047661076787 0.999996263683276 1 GO:0140375 immune receptor activity 25/5871 156/18639 0.16025641025641 0.508775205377147 0.999996999125045 1 GO:0005179 hormone activity 19/5871 132/18639 0.143939393939394 0.456972639011474 0.99999834244732 1 GO:0015370 solute:sodium symporter activity 8/5871 79/18639 0.10126582278481 0.321494408258572 0.999998412311869 1 GO:0098960 postsynaptic neurotransmitter receptor activity 6/5871 69/18639 0.0869565217391304 0.276065850569861 0.999998775189422 1 GO:0008188 neuropeptide receptor activity 2/5871 48/18639 0.0416666666666667 0.132281553398058 0.999999707511444 1 GO:0030594 neurotransmitter receptor activity 10/5871 97/18639 0.103092783505155 0.327294565108598 0.999999817940153 1 GO:0003730 mRNA 3'-UTR binding 41/5871 262/18639 0.156488549618321 0.496813162380494 0.999999998942098 1 GO:0003823 antigen binding 12/5871 174/18639 0.0689655172413793 0.218948778038165 1 1 GO:0030371 translation repressor activity 10/5871 329/18639 0.0303951367781155 0.0964971818101337 1 1 GO:0045182 translation regulator activity 14/5871 356/18639 0.0393258426966292 0.124850005454347 1 1