category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	33/401	82/9376	9.40964661516939	HLA-E/HSPA1A/HLA-A/HLA-C/HSPA1B/HSP90AA1/PSME1/PSME2/HLA-F/HLA-B/HLA-DRB1/HSP90AB1/HLA-DRA/HSPA8/CTSB/TAPBP/HLA-DPA1/HLA-DPB1/TAP1/B2M/TNF/HLA-G/IFI30/CANX/HLA-DMA/HLA-DQA1/CTSL/LGMN/HSPA6/HLA-DMB/HSPA2/TAP2/KIR2DL3	16.1667951183169
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	33/401	180/9376	4.28661679135495	HLA-E/HLA-A/HLA-C/CCL5/HLA-F/HLA-B/HLA-DRB1/HLA-DRA/NFKBIA/TAPBP/HLA-DPA1/HLA-DPB1/TAP1/B2M/TNFRSF14/TNF/HLA-G/IRF7/HLA-DMA/DAXX/IRF9/LTA/SRSF2/HLA-DQA1/SRSF3/BIRC3/HLA-DMB/SOCS3/TAP2/CGAS/IFNGR2/NXF1/IFNAR2	9.41079768269384
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	34/401	205/9376	3.87791496867587	HLA-E/HLA-A/HLA-C/HLA-F/JUN/HLA-B/HLA-DRB1/HLA-DRA/PLCG2/NFKBIA/TAPBP/HLA-DPA1/HLA-DPB1/TAP1/B2M/TNF/HLA-G/PSMC4/IRF7/NFKBIB/GADD45B/HLA-DMA/CDKN1A/IRF9/HLA-DQA1/CCND2/NFKBIE/GADD45G/MYC/HLA-DMB/TAP2/CCNE1/ICAM1/IFNAR2	8.80617147294989
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/401	44/9376	8.50238041260485	HLA-E/HLA-A/HLA-C/HLA-F/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/TNF/HSPD1/HLA-G/HLA-DMA/LTA/HLA-DQA1/HLA-DMB	10.543350652522
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	35/401	224/9376	3.65336658354115	HLA-E/HLA-A/HLA-C/EGR1/HLA-F/JUN/HLA-B/HLA-DRB1/ZFP36/HLA-DRA/NFKBIA/HLA-DPA1/HLA-DPB1/B2M/GPS2/TNF/FOS/HLA-G/CANX/MAD1L1/ATF4/HLA-DMA/CDKN1A/LTA/HLA-DQA1/CCND2/PRKACA/HRAS/MYC/HLA-DMB/ATF6B/CCNE1/ICAM1/IL2RA/MSX2	8.49579167729956
Human Diseases	Immune disease	hsa05330	Allograft rejection	15/401	39/9376	8.9929023594859	HLA-E/HLA-A/HLA-C/HLA-F/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/TNF/HLA-G/HLA-DMA/HLA-DQA1/HLA-DMB/CD40LG	10.5724034488706
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	22/401	95/9376	5.41467384171151	LTB/CCL5/ATP6V0C/JUN/HLA-DRB1/HLA-DRA/HLA-DPA1/FLT1/HLA-DPB1/CCL3/TNF/FOS/HLA-DMA/HLA-DQA1/CTSL/HLA-DMB/CXCL8/CCL3L1/CCL20/IL23A/ICAM1/VEGFA	9.14120893379356
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	15/401	45/9376	7.79384871155445	HLA-E/HLA-A/HLA-C/HLA-F/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/TNF/HLA-G/HLA-DMA/HLA-DQA1/HLA-DMB/KIR2DL3	9.65603051695482
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	27/401	155/9376	4.07291448797361	HLA-E/HLA-A/HLA-C/HLA-F/ATP6V0C/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/TAP1/TUBB/TUBB4B/HLA-G/CANX/HLA-DMA/HLA-DQA1/TUBB2A/CTSL/TUBA1A/TUBA1B/CD14/HLA-DMB/MRC1/NCF4/TAP2/FCGR2A	8.15394746444184
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	22/401	109/9376	4.71921114644581	HSP90AA1/JUN/HLA-DRB1/HSP90AB1/HLA-DRA/NFKBIA/HLA-DPA1/HLA-DPB1/IL27RA/FOS/AHR/NFKBIB/HLA-DMA/HLA-DQA1/NFKBIE/EBI3/HLA-DMB/FOXP3/IL23A/IFNGR2/IL2RA/RXRB	8.25534253788195
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	36/401	275/9376	3.06085694853775	HSPA1A/HSPA1B/CCL5/EGR1/HSPA8/PSMB3/NDUFA6/TUBB/CSNK2B/TNF/PSMA2/TUBB4B/NDUFA3/PSMC4/NDUFA7/PSMA6/NDUFS3/ATF4/NDUFA13/MT-CO3/TUBB2A/PRKACA/TUBA1A/SOD1/TUBA1B/HSPA6/C1QA/DDIT3/C1QB/NDUFS1/ATF6B/MT-ND1/NCF4/PPIF/C1QC/NDUFA11	7.33179363421131
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/401	54/9376	6.06188233120901	HLA-E/HLA-A/HLA-C/HLA-F/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-G/HLA-DMA/HLA-DQA1/HLA-DMB/CD40LG	7.88487788700771
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	28/401	205/9376	3.19357703302719	HLA-E/HLA-A/HLA-C/HLA-F/JUN/HLA-B/YWHAE/NFKBIA/CDC42/ACTN4/HLA-G/IRF7/CHD4/MAD1L1/ATF4/DDX3X/CDKN1A/IRF9/MRPS18B/CCND2/PRKACA/HRAS/EGR3/PMAIP1/DNAJA3/GTF2H1/ATF6B/CCNE1	6.71215644041416
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	20/401	112/9376	4.1752760954756	HSPA1A/HSPA1B/HLA-DRB1/HLA-DRA/HSPA8/NFKBIA/HLA-DPA1/HLA-DPB1/TNF/NFKBIB/HLA-DMA/HLA-DQA1/BIRC3/HSPA6/HLA-DMB/SOCS1/IL10RB/CD40LG/PPIF/IFNGR2	7.14548690920327
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	29/401	227/9376	2.98706977050765	HLA-E/HLA-A/HLA-C/CCL5/HLA-F/HLA-B/CCL4/NFKBIA/TAPBP/TAP1/B2M/CCL3/TNF/HLA-G/CCL4L2/GNG10/ATF4/CDKN1A/PRKACA/HRAS/MYC/CXCL8/ATF6B/CCL3L1/IL10RB/CALM2/TAP2/CGAS/VEGFA	6.40589516700766
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	32/401	268/9376	2.79182640413891	PSMB3/NDUFA6/UBB/TUBB/DUSP1/PSMA2/TUBB4B/NDUFA3/PSMC4/NDUFA7/PSMA6/UBC/NDUFS3/ATF4/DAXX/SLC39A1/NDUFA13/MT-CO3/TUBB2A/PRKACA/TUBA1A/SOD1/SLC39A7/TUBA1B/DDIT3/ADORA2A/NDUFS1/SLC39A4/MT-ND1/CALM2/PPIF/NDUFA11	6.29060497308413
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	16/401	78/9376	4.79621459172581	JUN/HLA-DRB1/HLA-DRA/NFKBIA/HLA-DPA1/HLA-DPB1/TNF/FOS/NFKBIB/HLA-DMA/HLA-DQA1/MARCKSL1/HLA-DMB/NCF4/IFNGR2/FCGR2A	7.11613011705945
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/401	70/9376	5.01033131457072	HLA-E/HLA-A/HLA-C/HLA-F/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-G/HLA-DMA/HLA-DQA1/HLA-DMB/CD40LG/ICAM1	7.11849763764068
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/401	216/9376	2.92269326683292	HSPA1A/HSPA1B/HSP90AA1/CCL5/JUN/HSP90AB1/HSPA8/NFKBIA/CDC42/CCL3/TNF/FOS/HSPD1/IRF7/ATF4/HRAS/HSPA6/CD14/DDIT3/CXCL8/HSPA2/CCL3L1/CALM2/CD40LG/NCF4/ICAM1/RXRB	6.04268200322529
Human Diseases	Immune disease	hsa05310	Asthma	10/401	32/9376	7.30673316708229	PRG2/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/TNF/HLA-DMA/HLA-DQA1/HLA-DMB/CD40LG	7.55359380464346
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	33/401	300/9376	2.57197007481297	HSPA1A/HSPA1B/JUN/HSPA8/NR4A1/CDC42/FLT1/DUSP1/TNF/FOS/DUSP16/JUND/GADD45B/ATF4/DUSP2/DAXX/DUSP8/PRKACA/RPS6KA1/MKNK2/HRAS/HSPA6/CD14/GADD45G/MYC/DDIT3/HSPB1/PPM1B/CSF1R/DUSP9/MAP4K1/EFNA1/VEGFA	5.84922400788185
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/401	196/9376	2.98234006819686	HLA-E/HLA-A/HLA-C/HLA-F/JUN/HLA-B/ZFP36/PLCG2/NFKBIA/UBB/FOS/HLA-G/IRF7/UBC/GNG10/CDKN1A/IRF9/HRAS/MYC/CXCL8/CALM2/MICB/ICAM1/IFNAR2/VEGFA	5.92823553420634
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/401	93/9376	3.77121711849409	JUN/HLA-DRB1/HLA-DRA/NFKBIA/HLA-DPA1/HLA-DPB1/FOS/NFKBIB/HLA-DMA/HLA-DQA1/NFKBIE/MAML1/HLA-DMB/IFNGR2/IL2RA	5.67686345125686
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	20/401	160/9376	2.92269326683292	HLA-E/HLA-A/HLA-C/HLA-F/HLA-B/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-G/HLA-DMA/PDCD1/HLA-DQA1/HLA-DMB/PTPRF/CD40LG/F11R/CLDN7/ICAM1/SDC4	5.18488776213525
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/401	66/9376	4.25119020630243	JUN/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/TNF/HLA-DMA/HLA-DQA1/HLA-DMB/FOXP3/IL23A/IFNGR2	5.6024772438304
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/401	56/9376	4.59280370502316	HSPA1A/EEF1G/HSPA1B/HSPA8/NFKBIA/TNF/HSPD1/HSF1/HSPA6/CD14/CXCL8	5.69980690498653
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/401	137/9376	3.07202795929883	JUN/NFKBIA/CTSB/TNF/FOS/GADD45B/ATF4/DAXX/MCL1/CTSL/LMNA/HRAS/TUBA1A/TUBA1B/BIRC3/GADD45G/PMAIP1/DDIT3	5.16397352767357
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	25/401	238/9376	2.45604476204447	RPS9/RPS25/RPS18/RPL7A/RPS17/RPL36A/RPL17/JUN/PLCG2/NFKBIA/RPS10/TNF/FOS/NFKBIB/IRF9/RPL26/C1QA/F13A1/C1QB/CXCL8/CGAS/RPS4Y1/C1QC/FCGR2A/IFNAR2	4.80925963692268
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/401	105/9376	3.34022087638048	LTB/CCL4/PLCG2/NFKBIA/CSNK2B/TNF/GADD45B/CCL4L2/LTA/BIRC3/CD14/GADD45G/CXCL8/CD40LG/ICAM1	5.09716631192251
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	19/401	157/9376	2.8296138634306	HLA-E/HLA-A/HLA-C/HLA-F/HLA-B/SQSTM1/HLA-G/SERPINE1/GADD45B/CDKN1A/ZFP36L1/CCND2/HRAS/GADD45G/MYC/CXCL8/CALM2/CCNE1/LIN37	4.88661312315674
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	20/401	173/9376	2.70306891730212	CCL5/HLA-DRB1/HLA-DRA/DNAJB1/NFKBIA/HLA-DPA1/HLA-DPB1/TNF/IRF7/NFKBIB/HLA-DMA/IRF9/HLA-DQA1/HLA-DMB/CXCL8/SOCS3/IFNGR2/ICAM1/NXF1/IFNAR2	4.77893539153278
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/401	109/9376	3.21764396348578	CCL5/SPP1/JUN/CCL4/NFKBIA/CCL3/TNF/FOS/IRF7/CCL4L2/IRF9/CD14/CXCL8/CCL3L1/IFNAR2	4.92239075029026
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/401	298/9376	2.19692379788783	LTB/CCL5/CCL4/TNFRSF14/CCL3/TNF/IL27RA/CSH1/CCL4L2/LTA/EBI3/CXCL8/INHBA/TNFRSF18/CCL3L1/CCL20/GDF15/IL10RB/CSF1R/CD40LG/IL23A/IFNGR2/CCR7/IL11RA/IL2RA/IL1RN/TNFRSF25/IFNAR2	4.43833562874243
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/401	100/9376	3.27341645885287	CCL5/CCL4/TNFRSF14/CCL3/TNF/CCL4L2/LTA/CXCL8/CCL3L1/CCL20/IL10RB/CSF1R/CCR7/IL2RA	4.83102434165859
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/401	181/9376	2.58359625797385	LSP1/ATP6V0C/HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/TNF/HSPD1/HLA-DMA/HLA-DQA1/CD14/HLA-DMB/MRC1/PLK3/IL10RB/CALM2/IL23A/IFNGR2/CEBPB/FCGR2A	4.54724635369959
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	17/401	142/9376	2.79919918513575	FOSB/JUN/PLCG2/NFKBIA/SQSTM1/TNF/FOS/JUND/IRF9/JUNB/SOCS1/SOCS3/CSF1R/NCF4/IFNGR2/FCGR2A/IFNAR2	4.56634876582898
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/401	103/9376	3.17807423189599	CCL5/JUN/NFKBIA/CCL3/TNF/FOS/SERPINE1/PPP2CA/C1QA/C1QB/CXCL8/CCL3L1/IFNGR2/C1QC	4.69809457826533
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	18/401	157/9376	2.68068681798688	JUN/CDC42/NDUFA6/TNF/FOS/NDUFA3/NDUFA7/NDUFS3/ATF4/NDUFA13/ADIPOR2/MT-CO3/DDIT3/CXCL8/SOCS3/NDUFS1/NDUFA11/PRKAG1	4.48885222442062
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/401	133/9376	2.81281758010988	HLA-E/HLA-A/HLA-C/HLA-B/PLCG2/TNF/HLA-G/HRAS/KLRK1/ULBP2/NCR3/MICB/KIR2DL3/IFNGR2/ICAM1/IFNAR2	4.45055368433045
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	13/401	99/9376	3.07030403788509	HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/KRT18/C1QA/HLA-DMB/C1QB/ICAM1/C1QC/FCGR2A	4.37712091683501
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	23/401	248/9376	2.1684498431341	HSP90AA1/JUN/HSP90AB1/NFKBIA/CDC42/TUBB/TNF/FOS/TUBB4B/SKP1/DYNLRB1/GSDMD/RHOB/DYNLL1/TUBB2A/ARPC1B/HRAS/TUBA1A/TUBA1B/BIRC3/CD14/MYC/CXCL8	3.94174654111127
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	18/401	174/9376	2.41878063462035	HSPA1A/HSPA1B/HSP90AA1/DNAJA1/HSPH1/HSP90AB1/HSPA8/DNAJB1/SKP1/CANX/PPP1R15A/RNF5/ATF4/HYOU1/HSPA6/DDIT3/ATF6B/BCAP29	3.99290849451058
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	30/401	368/9376	1.90610430445625	PSMB3/NDUFA6/CHCHD10/SQSTM1/TUBB/TNF/PSMA2/TUBB4B/NDUFA3/PSMC4/NDUFA7/PSMA6/NDUFS3/ATF4/HNRNPA2B1/DAXX/NDUFA13/MT-CO3/TUBB2A/SRSF3/TUBA1A/SOD1/TUBA1B/FUS/DDIT3/NDUFS1/MT-ND1/SMCR8/NXF1/NDUFA11	3.74824965764207
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	14/401	119/9376	2.7507701334898	CCL5/JUN/NFKBIA/TNF/FOS/ATF4/LTA/JUNB/BIRC3/SOCS3/ATF6B/CCL20/CEBPB/ICAM1	4.0626375105211
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/401	46/9376	4.06635584950667	PSME1/PSME2/PSMB8/PSMB9/PSMB3/PSMA2/PSMC4/PSMA6	4.40657577918435
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/401	136/9376	2.57884700014669	HSPA1A/HSPA1B/JUN/HSPA8/NFKBIA/CSNK2B/FOS/IRF7/NFKBIB/IRF9/CCND2/HSPA6/CCNE1/IL2RA/IFNAR2	3.92025313450387
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	20/401	214/9376	2.18519122753863	HLA-E/HLA-A/HLA-C/HLA-F/JUN/HLA-B/PLCG2/NFKBIA/TAPBP/TAP1/B2M/TNF/FOS/HLA-G/SKP1/GNG10/HRAS/CALM2/TAP2/CGAS	3.70715519135952
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	15/401	139/9376	2.5231884317982	HSPA1A/HSPA1B/HSP90AA1/JUN/HSP90AB1/HSPA8/FOS/ATF4/PRKACA/FKBP4/HRAS/KRT18/HSPA6/ATF6B/CALM2	3.82416090135917
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	18/401	187/9376	2.25063010921893	HSP90AA1/CCL5/JUN/YWHAE/HSP90AB1/GPSM3/NFKBIA/CTSB/GABARAP/TNF/IRF7/GSDMD/NFKBIB/IRF9/BIRC3/ATG16L1/CXCL8/IFNAR2	3.65137261114822
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/401	100/9376	2.8057855361596	HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/TNF/HLA-DMA/HLA-DQA1/CD14/HLA-DMB/CSF1R/IL11RA/IL2RA	3.83730567579507
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	8/401	50/9376	3.74104738154613	HLA-DRB1/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/HLA-DMB/CD40LG	4.10765949277235
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/401	101/9376	2.77800548134614	FN1/EGR1/JUN/PLCG2/CDC42/TNF/SERPINE1/COL4A1/HRAS/CXCL8/ICAM1/VEGFA	3.79732194527859
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/401	78/9376	2.99763411982863	JUN/TNF/FOS/C1QA/CD14/C1QB/CXCL8/CALM2/IL23A/C1QC	3.74463138990137
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/401	93/9376	2.765559220229	FN1/NFKBIA/CKS2/GADD45B/CDKN1A/COL4A1/BIRC3/GADD45G/MYC/CCNE1/RXRB	3.61676410753196
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/401	94/9376	2.7361383774606	HSP90AA1/FOSB/JUN/HSP90AB1/NFKBIA/TNF/FOS/JUND/CXCL8/CCL20/CEBPB	3.57575766232607
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/401	168/9376	2.22681391758698	IL27RA/CSH1/CDKN1A/IRF9/MCL1/CCND2/HRAS/MYC/SOCS1/SOCS3/IL10RB/IL23A/IFNGR2/IL11RA/IL2RA/IFNAR2	3.3914957379405
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/401	70/9376	3.00619878874243	NFKBIA/TNF/NFKBIB/ADIPOR2/NFKBIE/SOCS3/PCK2/RXRB/PRKAG1	3.56108266826061
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/401	143/9376	2.28910241877823	HLA-DRB1/HLA-DRA/HLA-DPA1/ACTN4/HLA-DPB1/TNF/HLA-DMA/HLA-DQA1/C1QA/HLA-DMB/C1QB/CD40LG/C1QC/FCGR2A	3.28340624685773
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/401	37/9376	3.79160207589135	GADD45B/CDKN1A/HRAS/GADD45G/MYC/RXRB	3.59620783442883
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	28/401	388/9376	1.68732807157364	PSMB3/NDUFA6/TUBB/CSNK2B/TNF/PSMA2/TUBB4B/NDUFA3/PSMC4/NDUFA7/PSMA6/NDUFS3/ATF4/SLC39A1/NDUFA13/MT-CO3/TUBB2A/HRAS/TUBA1A/SLC39A7/TUBA1B/DDIT3/NDUFS1/SLC39A4/MT-ND1/CALM2/PPIF/NDUFA11	2.9227320930129
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/401	62/9376	3.01697369479527	HSPA1A/HSPA1B/HSPA8/PRKACA/HRAS/SOD1/HSPA6/PRKAG1	3.36797266510355
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/401	50/9376	3.27341645885287	TNF/KLRK1/CXCL8/CD40LG/HBA2/ICAM1/HBA1	3.40688043596109
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/401	105/9376	2.44949530934568	LSP1/JUN/PLCG2/NFKBIA/TNF/IRF9/HRAS/EGR3/PLK3/CALM2/IL23A	3.15710313272383
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	26/401	362/9376	1.679337567683	FN1/HSP90AA1/SPP1/YWHAE/HSP90AB1/NR4A1/FLT1/CSH1/GNG10/ATF4/CDKN1A/MCL1/CCND2/COL4A1/HRAS/PPP2CA/MYC/SGK1/ATF6B/PCK2/CSF1R/CCNE1/IL2RA/EFNA1/IFNAR2/VEGFA	2.78626061611386
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/401	110/9376	2.33815461346633	LDHA/PLCG2/FLT1/SERPINE1/EGLN2/CDKN1A/MKNK2/EGLN1/EPAS1/IFNGR2/VEGFA	2.98398809579052
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/401	142/9376	2.14056408275087	HSP90AA1/JUN/HSP90AB1/SQSTM1/DUSP1/TNF/FOS/CTSL/GSTM3/CALM2/ICAM1/SDC4/VEGFA	2.89473974568599
Genetic Information Processing	Transcription	hsa03040	Spliceosome	19/401	243/9376	1.82818673480907	HSPA1A/HSPA1B/HSPA8/DDX39B/LSM2/CWC25/PRPF8/RBM8A/PUF60/SRSF2/HNRNPU/DHX16/PRPF31/SRSF3/EIF4A3/HSPA6/FUS/PRPF38B/TRA2B	2.76480988749285
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	32/401	480/9376	1.55876974231089	PSMB3/NDUFA6/UBB/SQSTM1/TUBB/CSNK2B/TNF/PSMA2/TUBB4B/NDUFA3/PSMC4/NDUFA7/PSMA6/UBC/NDUFS3/ATF4/DAXX/NDUFA13/MT-CO3/TUBB2A/HRAS/TUBA1A/SOD1/TUBA1B/FUS/DDIT3/NDUFS1/MT-ND1/SMCR8/CALM2/PPIF/NDUFA11	2.65641979751117
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	18/401	227/9376	1.85404330583234	JUN/NFKBIA/NDUFA6/FOS/NDUFA3/AHR/NDUFA7/NDUFS3/NDUFA13/MT-CO3/HRAS/SOD1/NDUFS1/GSTM3/MT-ND1/PPIF/NDUFA11/VEGFA	2.75325605897014
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/401	70/9376	2.67217670110438	JUN/CDC42/EGLN2/CDKN1A/HRAS/EGLN1/EPAS1/VEGFA	2.96818017336394
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/401	163/9376	2.00823095635145	JUN/NFKBIA/TNF/FOS/IRF7/ATF4/DDX3X/CDKN1A/HRAS/EGR3/MYC/CXCL8/ATF6B/CCNE1	2.74469373012638
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/401	71/9376	2.63454040953953	CCL5/ATP6V0C/JUN/PLCG2/NFKBIA/CDC42/CXCL8/F11R	2.92218187912204
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	19/401	250/9376	1.77699750623441	HLA-E/HSPA1A/HLA-A/HLA-C/ACAP1/HSPA1B/HLA-F/HLA-B/HSPA8/CDC42/CHMP4A/VPS28/HLA-G/ARPC1B/HRAS/HSPA6/RUFY1/CHMP1B/IL2RA	2.63202489625726
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/401	201/9376	1.86121760275927	FLT1/GADD45B/CDKN1A/CCND2/BIRC3/CD14/GADD45G/MYC/FUS/DDIT3/CXCL8/NFKBIZ/CSF1R/CEBPB/TAF15/RXRB	2.60884625592836
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/401	103/9376	2.27005302278285	FN1/ACTN4/TNF/COL4A1/PRKACA/ARG2/CD14/HSPB1/CXCL8/PRDX1	2.73949764111186
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	22/401	308/9376	1.67011043819024	PSMB3/POLR2A/NDUFA6/TUBB/PSMA2/TUBB4B/NDUFA3/POLR2J3/PSMC4/NDUFA7/PSMA6/NDUFS3/NDUFA13/MT-CO3/TUBB2A/TUBA1A/SOD1/TUBA1B/NDUFS1/MT-ND1/PPIF/NDUFA11	2.52758972555288
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	11/401	120/9376	2.14330839567747	JUN/YWHAE/PLCG2/NFKBIA/CDC42/NFKBIB/ATF4/NFKBIE/RPS6KA1/HRAS/CALM2	2.66429885783946
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/401	75/9376	2.49403158769742	SERPINE1/GADD45B/CDKN1A/SESN2/CCND2/GADD45G/PMAIP1/CCNE1	2.74578283079725
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/401	90/9376	2.33815461346633	JUN/NFKBIA/CSNK2B/FOS/NFKBIB/PDCD1/NFKBIE/HRAS/IFNGR2	2.69621056826106
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/401	122/9376	2.10817219246965	JUN/NFKBIA/CDC42/TNF/FOS/NFKBIB/PDCD1/NFKBIE/HRAS/PPP2CA/CD40LG	2.60413210504618
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	23/401	333/9376	1.61494162491669	HLA-E/HLA-A/FN1/HLA-C/SPP1/HLA-F/ATP6V0C/HLA-B/CDC42/TNF/HLA-G/CHD4/CDKN1A/IRF9/CCND2/COL4A1/PRKACA/HRAS/PPP2CA/MAML1/CCNE1/IFNAR2/VEGFA	2.41512903060444
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/401	78/9376	2.39810729586291	HSPD1/LSM2/BTG2/BTG1/EXOSC4/PARN/BTG3/CNOT3	2.62079848084867
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/401	193/9376	1.81721861150233	CCL5/CCL4/PLCG2/NFKBIA/CDC42/CCL3/NFKBIB/CCL4L2/GNG10/PRKACA/HRAS/CXCL8/CCL3L1/CCL20/CCR7	2.42474016807553
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/401	110/9376	2.12559510315121	TNF/ID3/SKP1/SMAD7/PPP2CA/ID1/MYC/INHBA/TGIF2/FBN1	2.50999574689119
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	18/401	253/9376	1.66350921116182	CCL5/JUN/PLCG2/NFKBIA/CDC42/ACTN4/UBB/SQSTM1/TNF/SKP1/UBC/NFKBIB/ARPC1B/CD14/ATG16L1/CXCL8/CGAS/TIFA	2.26140826643981
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/401	15/9376	4.67630922693267	HEXB/ST6GALNAC6/B3GALT4	3.01187634117541
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	15/401	200/9376	1.75361596009975	JUN/NFKBIA/CDC42/TUBB/TNF/FOS/TUBB4B/NFKBIB/TUBB2A/ARPC1B/TUBA1A/TUBA1B/CXCL8/CLDN7/FCGR2A	2.27708361687858
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/401	83/9376	2.25364300093141	CCL5/CCL4/NFKBIA/IRF7/GSDMD/NFKBIB/CCL4L2/CGAS	2.42479793693107
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/401	133/9376	1.93381208632554	GABARAP/GADD45B/CDKN1A/CCND2/HRAS/GADD45G/SGK1/PLK3/PLK2/PCK2/PRKAG1	2.29255324245947
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/401	69/9376	2.37204091221222	FOSB/JUN/FOS/ATF4/PRKACA/ATF6B/CALM2	2.4178388182602
Genetic Information Processing	Translation	hsa03010	Ribosome	16/401	222/9376	1.68515647817393	RPS9/RPS25/RPS18/RPL7A/RPS17/RPL36A/RPL17/RPS10/MRPS12/MRPS24/RPL26/MRPS18B/MRPL18/MRPL38/MRPL23/RPS4Y1	2.18374235413839
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/401	41/9376	2.85140806520285	CDKN1A/HRAS/MYC/CXCL8/VEGFA	2.51117809521671
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/401	170/9376	1.78800058676837	JUN/CDC42/ACTN4/PRKACA/ARPC1B/PPP2CA/TUBA1A/RAPGEF6/TUBA1B/ARHGAP17/F11R/CLDN7/PRKAG1	2.19157386215713
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/401	87/9376	2.15002723077364	JUN/FOS/GADD45B/CDKN1A/HRAS/GADD45G/MYC/PMAIP1	2.27784340662181
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	11/401	138/9376	1.86374643102389	ATP6V0C/NDUFA6/NDUFA3/NDUFA7/NDUFS3/NDUFA13/MT-CO3/ATP5MG/NDUFS1/MT-ND1/NDUFA11	2.16061519493348
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	12/401	156/9376	1.79858047189718	YWHAE/NFKBIA/TNF/IRF7/CDKN1A/IRF9/HRAS/PPP2CA/MYC/SOCS3/CLDN7/IFNAR2	2.12596504938073
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/401	105/9376	2.00413252582829	JUN/GABARAP/UBB/SQSTM1/CSNK2B/UBC/ATF4/HRAS/CITED2	2.18707154312449
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/401	122/9376	1.9165201749724	PLCG2/FOS/CSH1/ATF4/PRKACA/JUNB/HRAS/SOCS1/SOCS3/ATF6B	2.15376241055928
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/401	90/9376	2.07835965641452	ATF4/ADIPOR2/SESN2/PRKACA/HRAS/EHMT2/ATF6B/PRKAG1	2.17275692416416
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/401	91/9376	2.05552053931106	JUN/PLCG2/NFKBIA/FOS/NFKBIB/INPP5D/NFKBIE/HRAS	2.13863675612338
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	15/401	217/9376	1.61623590792604	HSP90AA1/JUN/HSP90AB1/FOS/AHR/ATF4/PRKACA/RPS6KA1/HRAS/KLF4/MYC/GSTM3/ATF6B/RXRB/VEGFA	1.94130348534398
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/401	130/9376	1.79858047189718	JUN/NFKBIA/FOS/GNG10/ATF4/COL4A1/PRKACA/HRAS/ATF6B/VEGFA	1.93800107424601
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/401	149/9376	1.72615441262615	NDUFA6/NDUFA3/NDUFA7/NDUFS3/GNG10/NDUFA13/PRKACA/NDUFS1/MT-ND1/NAPEPLD/NDUFA11	1.88856723406785
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/401	49/9376	2.38587205455748	FOSB/JUN/ATF4/PRKACA/ATF6B	2.05584697405994
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/401	115/9376	1.829860132278	EGR1/FOS/JUND/ATF4/CDKN1A/PRKACA/SGK1/ATF6B/RXRB	1.89262893273677
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/401	98/9376	1.90869764364599	PLCG2/CDC42/INPP5D/ARPC1B/MARCKSL1/PLPP2/MARCKS/FCGR2A	1.91137478083978
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/401	138/9376	1.69431493729445	FLOT1/PRKACA/MKNK2/HRAS/PTPRF/SOCS1/SOCS3/PCK2/CALM2/PRKAG1	1.73679143520094
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/401	138/9376	1.69431493729445	FN1/JUN/NFKBIA/CDC42/TNF/FOS/RPS6KA1/ARPC1B/CXCL8/FCGR2A	1.73679143520094
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/401	37/9376	2.5277347172609	TNF/HBA2/ICAM1/HBA1	1.96806400403193
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/401	157/9376	1.63819749988087	DUSP16/SLC16A1/STAB1/DUSP2/DUSP8/ARG2/C1QA/SGK1/C1QB/CEBPB/C1QC	1.70452593326777
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/401	158/9376	1.62782916127403	YWHAE/CDKN1C/SKP1/GADD45B/MAD1L1/CDKN1A/CCND2/PPP2CA/GADD45G/MYC/CCNE1	1.68225671802996
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	15/401	235/9376	1.49243911497851	NDUFA6/NDUFA3/NDUFA7/NDUFS3/SMARCB1/NDUFA13/MT-CO3/PRKACA/RPS6KA1/HRAS/ATP5MG/NDUFS1/MT-ND1/NDUFA11/PRKAG1	1.61595854224472
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/401	55/9376	2.12559510315121	NEU1/HEXB/SGPP1/PLPP2/PSAP	1.76959092199026
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/401	89/9376	1.8389980105915	TUBB/TUBB4B/TUBB2A/PRKACA/HRAS/TUBA1A/TUBA1B	1.68096552852675
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/401	72/9376	1.94846217788861	NFKBIA/TNF/IRF7/NFKBIB/DDX3X/CXCL8	1.70762305751792
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/401	144/9376	1.62371848157384	NFKBIA/TNF/ADIPOR2/C1QA/CD14/C1QB/CXCL8/TRA2B/C1QC/PRKAG1	1.59427250755577
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/401	73/9376	1.92177091517781	PLCG2/GADD45B/CDKN1A/HRAS/GADD45G/RXRB	1.67114262271603
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/401	93/9376	1.75990132196391	EGR1/JUN/CDC42/ATF4/PRKACA/HRAS/CALM2	1.55666476380706
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/401	168/9376	1.53093456834105	HSP90AA1/HSP90AB1/CHMP4A/SQSTM1/TNF/IRF9/FTL/BIRC3/CHMP1B/IFNGR2/IFNAR2	1.4677550522052
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/401	76/9376	1.84591153694711	PLCG2/GADD45B/CDKN1A/HRAS/GADD45G/CALM2	1.56505954605717
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/401	59/9376	1.98148696056469	GADD45B/CDKN1A/HRAS/GADD45G/MYC	1.59850164731687
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/401	169/9376	1.521875783913	CTSB/GABARAP/UBB/SQSTM1/UBC/CTSL/PRKACA/HRAS/PPP2CA/ATG16L1/SMCR8	1.44707826932402
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/401	77/9376	1.8219386598439	NFKBIA/GADD45B/CDKN1A/HRAS/GADD45G/MYC	1.53076048404287
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/401	60/9376	1.94846217788861	PLCG2/CDC42/HRAS/HSPB1/VEGFA	1.55783514808293
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/401	78/9376	1.79858047189718	PLCG2/INPP5D/PIP4K2B/TPI1/ITPK1/ISYNA1	1.49696557179598
NA	NA	hsa04518	Integrin signaling	10/401	154/9376	1.51828221653658	FN1/SPP1/CDC42/FLT1/ACTN4/CCND2/COL4A1/ICAM1/FBN1/VEGFA	1.37073879608572
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	9/401	138/9376	1.524883443565	YWHAE/SKP1/MAD1L1/PRKACA/RPS6KA1/PPP2CA/CALM2/REC8/CCNE1	1.31296767546839
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/401	65/9376	1.79858047189718	DGAT1/AGPAT1/PLPP2/ABHD16A/AGPAT5	1.3655820415586
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/401	103/9376	1.58903711594799	DDX39B/RBM8A/EIF4A3/PPP2CA/FUS/NUDT21/NXF1	1.27054993824676
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/401	32/9376	2.19201995012469	GABARAP/PPP2CA/ATG16L1	1.42768597810185
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/401	67/9376	1.74489150258682	ATF4/PRKACA/RPS6KA1/HRAS/CALM2	1.29336022879601
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	12/401	203/9376	1.3821603626402	FN1/SPP1/JUN/CDC42/FLT1/ACTN4/ZYX/CCND2/COL4A1/HRAS/BIRC3/VEGFA	1.16353260687161
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	12/401	204/9376	1.3753850667449	FN1/PLCG2/CDC42/TIMP3/TNF/CDKN1A/CTSL/PRKACA/HRAS/MYC/SDC4/VEGFA	1.14577844671042
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/401	50/9376	1.87052369077307	AOC1/SAT1/AMD1/ARG2	1.30454326552729
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/401	106/9376	1.54406436738343	HSP90AA1/HSP90AB1/NFKBIA/ATF4/CDKN1A/HRAS/CCNE1	1.19070436269197
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/401	88/9376	1.59419632736341	SERPINE2/SERPINE1/C1QA/F13A1/C1QB/C1QC	1.18372492328527
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/401	18/9376	2.59794957051815	NEU1/HEXB	1.43432773860318
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/401	109/9376	1.50156718296003	NFKBIA/TNF/RPS6KA1/PTPRF/SOCS3/PCK2/PRKAG1	1.11330299304261
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/401	71/9376	1.64658775596221	FOS/CCND2/HRAS/SOCS1/SOCS3	1.15595002283683
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/401	71/9376	1.64658775596221	LDHA/HRAS/MYC/TIGAR/SLC1A5	1.15595002283683
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/401	19/9376	2.46121538259614	HEXB/IDS	1.34760718278785
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/401	20/9376	2.33815461346633	CYP51A1/FDFT1	1.26624219919405
NA	NA	hsa04517	IgSF CAM signaling	16/401	299/9376	1.25118641523282	PLCG2/CDC42/ACTN4/TUBB/TUBB4B/DYNLL1/INPP5D/TUBB2A/ARPC1B/TUBA1A/RAPGEF6/TUBA1B/PTPRF/PPFIA1/F11R/ICAM1	0.933041950137842
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/401	38/9376	1.84591153694711	SIRT2/PNP/NAPRT	1.10441019621964
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/401	38/9376	1.84591153694711	TAP1/CD40LG/TAP2	1.10441019621964
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/401	76/9376	1.53825961412259	UBC/PLTP/PCK2/RXRB/PLIN2	0.995858680896893
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/401	116/9376	1.4109553701952	PLCG2/CDC42/ACTN4/NCF4/F11R/CLDN7/ICAM1	0.941366538934254
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/401	77/9376	1.51828221653658	CDC42/GADD45B/CDKN1A/GADD45G/VEGFA	0.965237402030739
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/401	140/9376	1.33608835055219	EGR1/SPP1/SERPINE1/GNG10/PRKACA/HRAS/CALM2/PRKAG1	0.846868756745473
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/401	23/9376	2.03317792475333	POLD4/SSBP1	1.04858626562972
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/401	23/9376	2.03317792475333	PCK2/CA2	1.04858626562972
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/401	205/9376	1.25461954868925	NDUFA6/NDUFA3/NDUFA7/NDUFS3/NDUFA13/MT-CO3/NDUFS1/MT-ND1/NCF4/PPIF/NDUFA11	0.779113848229615
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/401	142/9376	1.31727020476977	UBB/SKP1/UBE2S/UBC/HERC3/BIRC3/SOCS1/SOCS3	0.805228470507237
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/401	184/9376	1.27073620297083	PLCG2/CDC42/HRAS/SEMA7A/EPHA1/EFNB2/EPHB6/RND1/SEMA6B/EFNA1	0.783954456497389
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/401	42/9376	1.67011043819024	SAT1/FTL/SLC3A2	0.919978601195472
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/401	43/9376	1.63127066055791	DGAT1/AGPAT1/PLPP2	0.876960022635307
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/401	83/9376	1.40852687558213	CSNK2B/SKP1/PHF1/RYBP/RING1	0.790173218656722
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/401	63/9376	1.48454261172466	POLR2A/POLD4/POLR2J3/GTF2H1	0.815639115473392
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/401	44/9376	1.59419632736341	TAF9/GTF2H1/TAF15	0.835044331437466
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/401	44/9376	1.59419632736341	DYNLL1/PRKACA/NSF	0.835044331437466
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/401	85/9376	1.3753850667449	NME2/IMPDH2/AK6/PNP/GMPR2	0.734845130418928
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/401	65/9376	1.43886437751774	NR4A1/ATF4/PRKACA/ATF6B	0.750463270400615
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/401	86/9376	1.35939221713159	JUN/PLCG2/CDKN1A/HRAS/MYC	0.707702341414841
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/401	107/9376	1.31111473652318	LDHA/ATF4/PRKACA/PCK2/CALM2/PRKAG1	0.684126835573255
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/401	46/9376	1.524883443565	HMOX2/FTL/ALAS1	0.75429558173443
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	12/401	238/9376	1.17890148578135	PLCG2/CDC42/FLT1/GNG10/RASA3/PRKACA/HRAS/CSF1R/SYNGAP1/CALM2/EFNA1/VEGFA	0.590904700859356
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/401	47/9376	1.49243911497851	TNF/SOCS1/SOCS3	0.715359782419091
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/401	68/9376	1.3753850667449	HRAS/CD14/MYC/CSF1R	0.656664981324983
NA	NA	hsa03272	Virion - Hepatitis viruses	3/401	48/9376	1.46134663341646	CHMP4A/CHMP1B/CLDN7	0.677320626866664
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/401	28/9376	1.67011043819024	ATP6V0C/CA2	0.750596686012947
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/401	69/9376	1.35545194983556	PLCG2/TNF/INPP5D/HRAS	0.626384763522088
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/401	133/9376	1.23060769129807	FOS/GNG10/ATF4/PRKACA/PPP2CA/ATF6B/CALM2	0.566152888962695
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/401	155/9376	1.20678947791811	NR4A1/AHR/ATF4/CDKN1A/PRKACA/ATF6B/CCNE1/RASD1	0.548713784826311
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/401	178/9376	1.18221300680882	JUN/NOTUM/CSNK2B/SKP1/CACYBP/CCND2/PRKACA/MYC/SFRP1	0.518780052970032
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/401	157/9376	1.19141636354972	YWHAE/SERPINE1/SMAD7/CCND2/PPP2CA/ID1/BIRC3/MYC	0.511243237059407
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/401	30/9376	1.55876974231089	TNF/SHMT1	0.647919745984939
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/401	51/9376	1.3753850667449	ATP6V0C/PLCG2/PRKACA	0.568169943503389
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/401	73/9376	1.28118061011854	CHMP4A/SUPT4H1/SMARCB1/NELFE	0.509771890730299
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/401	73/9376	1.28118061011854	GADD45B/CDKN1A/HRAS/GADD45G	0.509771890730299
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/401	117/9376	1.19905364793145	CHD4/INO80D/SMARCB1/TFPT/INO80B/SRCAP	0.457953756445415
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/401	32/9376	1.46134663341646	LDHA/BCKDHA	0.552556288595904
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/401	32/9376	1.46134663341646	BIRC3/PMAIP1	0.552556288595904
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/401	75/9376	1.24701579384871	CDKN1A/BIRC3/PMAIP1/GSTM3	0.453974153739851
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/401	75/9376	1.24701579384871	CANX/ATF4/PRKACA/ATF6B	0.453974153739851
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/401	97/9376	1.20523433683832	FOS/GNG10/PRKACA/CALM2/RASD1	0.42946314290648
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/401	54/9376	1.29897478525907	LDHA/AMD1/ADI1	0.465712064962028
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/401	98/9376	1.19293602727874	PLCG2/INPP5D/PIP4K2B/CALM2/ITPK1	0.405825919583512
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/401	98/9376	1.19293602727874	NR4A1/ATF4/PRKACA/ATF6B/CALM2	0.405825919583512
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	11/401	233/9376	1.1038498175163	FN1/ZYX/COL4A1/LMNA/FBLN1/TPM1/BGN/FBN1/SDC4/CSRP2/DSP	0.339296933230441
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/401	99/9376	1.18088616841734	JUN/FOS/CDKN1A/PRKACA/HRAS	0.382436886977481
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/401	99/9376	1.18088616841734	JUN/FOS/HRAS/CHKB/PLPP2	0.382436886977481
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/401	144/9376	1.13660293710169	ID3/HRAS/ID1/KLF4/MYC/INHBA/DUSP9	0.349167634928917
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/401	212/9376	1.10290311955959	CDC42/FLT1/HRAS/RAPGEF6/ID1/ADORA2A/CSF1R/CALM2/EFNA1/VEGFA	0.320327723205949
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/401	122/9376	1.14991210498344	PLCG2/PRKACA/HRAS/MYC/DIO2/RXRB	0.352283632611663
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/401	34/9376	1.3753850667449	POLR2A/POLR2J3	0.463486527615641
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/401	34/9376	1.3753850667449	SKP1/PRKAG1	0.463486527615641
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/401	170/9376	1.10030805339592	PLCG2/GADD45B/CDKN1A/SMARCB1/HRAS/GADD45G/MYC/GSTM3	0.278975056208914
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/401	35/9376	1.33608835055219	TIGAR/TPI1	0.421047789155221
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/401	148/9376	1.10588393880164	JUN/FOS/GADD45B/CDKN1A/HRAS/GADD45G/MYC	0.274440213814602
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/401	194/9376	1.08471090315448	TUBB/TUBB4B/DYNLRB1/DYNLL1/TUBB2A/TUBA1A/TUBA1B/TPM1/MYO19	0.252006723983642
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/401	36/9376	1.29897478525907	GALNT4/C1GALT1C1	0.379885721884427
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/401	36/9376	1.29897478525907	POLD4/SSBP1	0.379885721884427
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/401	104/9376	1.12411279493574	CHKB/AGPAT1/PLPP2/AGPAT5/MBOAT7	0.269021574279984
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/401	150/9376	1.09113881961762	GADD45B/CDKN1A/HRAS/GADD45G/MYC/CCNE1/RXRB	0.237838906684331
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/401	83/9376	1.1268215004657	ECH1/SOD1/DHRS4/PRDX1	0.245298312565274
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/401	61/9376	1.14991210498344	HMOX2/FTL/SLC39A4	0.248285173462098
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/401	154/9376	1.06279755157561	JUN/FOS/CDKN1A/PRKACA/HRAS/CALM2/PRKAG1	0.166085266863101
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/401	16/9376	1.46134663341646	MIF	0.390382210265148
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/401	16/9376	1.46134663341646	HEXB	0.390382210265148
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/401	63/9376	1.11340695879349	GADD45B/CDKN1A/GADD45G	0.190899931854527
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/401	110/9376	1.06279755157561	HSP90AA1/HSP90AB1/MAD1L1/PRKACA/RPS6KA1	0.140034002394534
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/401	323/9376	1.01344162812782	PLCG2/TIMP3/CDKN1A/MCL1/CCND2/HRAS/FSCN1/MYC/TPM1/SOCS1/CCNE1/MARCKS/EFNA1/VEGFA	0.0519633896529173
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/401	17/9376	1.3753850667449	CA2	0.327436677463145
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/401	41/9376	1.14056322608114	SHMT1/ALAS1	0.190654508296784
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/401	41/9376	1.14056322608114	POLD4/SSBP1	0.190654508296784
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/401	89/9376	1.05085600605228	FN1/SPP1/COL4A1/SDC4	0.101892009293526
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/401	89/9376	1.05085600605228	GABARAP/GNG10/PRKACA/NSF	0.101892009293526
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/401	18/9376	1.29897478525907	HSD17B8	0.268361302228687
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/401	18/9376	1.29897478525907	PRDX1	0.268361302228687
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/401	115/9376	1.01658896237667	FOS/GNG10/ATF4/PRKACA/HRAS	0.037833785401856
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/401	67/9376	1.04693490155209	LDHA/PCK2/TPI1	0.0814933917209694
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/401	19/9376	1.23060769129807	BCKDHA	0.212678147862953
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/401	44/9376	1.06279755157561	HEXB/MGAT4B	0.0882515375078893
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/401	93/9376	1.00565789826509	CDC42/ACTN4/CSNK2B/PTPRF	0.0115902560133839
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/401	69/9376	1.01658896237667	CTSB/PRKACA/CALM2	0.0292334119427188
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/401	191/9376	0.979331775273857	FOSB/GNG10/ATF4/PRKACA/HRAS/ADORA2A/ATF6B/CALM2	-0.0609987413956959
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/401	45/9376	1.03917982820726	TAP1/TAP2	0.0556859054242593
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/401	144/9376	0.974231088944306	PSMB3/PSMA2/PSMC4/PSMA6/PPIF/NOP56	-0.0658673226133658
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/401	47/9376	0.994959409985674	LDHA/PCK2	-0.00732239837623246
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/401	99/9376	0.944708934733872	TNF/LMNA/TPM1/PRKAG1	-0.11689861675471
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/401	22/9376	1.06279755157561	AOC1	0.0623298332160115
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/401	149/9376	0.941538770523356	PLCG2/HRAS/AGPAT1/PLPP2/CXCL8/AGPAT5	-0.152044744937401
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/401	49/9376	0.954348821822993	GALNT4/C1GALT1C1	-0.0677204192182354
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/401	75/9376	0.935261845386534	ARG2/SHMT1/TPI1	-0.118978015524497
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	10/401	250/9376	0.935261845386534	ATP6V0C/NEU1/CTSB/HEXB/IDS/BORCS5/CTSL/LGMN/CLN8/PSAP	-0.219295986554928
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/401	23/9376	1.01658896237667	ARG2	0.0168363625397574
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/401	23/9376	1.01658896237667	B3GALNT2	0.0168363625397574
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/401	76/9376	0.922955768473553	PRKACA/CALM2/CA2	-0.142543049423671
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/401	128/9376	0.913341645885287	NME2/IMPDH2/AK6/PNP/GMPR2	-0.208656590428439
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/401	154/9376	0.910969329921948	ATF4/PRKACA/PPP2CA/TPM1/ATF6B/CALM2	-0.235465909544438
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/401	78/9376	0.89929023594859	FN1/CDC42/ARPC1B	-0.188783791783062
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/401	52/9376	0.89929023594859	PLTP/APOC2	-0.153926258744631
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/401	105/9376	0.890725567034794	TNF/PRKACA/LMNA/TPM1	-0.238007430873857
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/401	80/9376	0.876807980049875	PLCG2/HRAS/VEGFA	-0.233894553108929
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/401	158/9376	0.88790681524038	TNF/SESN2/RPS6KA1/HRAS/SGK1/SLC3A2	-0.300351631842947
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	4/401	108/9376	0.865983190172716	DDX39B/RBM8A/EIF4A3/NXF1	-0.296086588936331
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/401	82/9376	0.855422419560854	NME2/IMPDH2/GSTM3	-0.277937495904467
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/401	56/9376	0.835055219095119	CCND2/PRKACA	-0.261676806842713
NA	NA	hsa04382	Cornified envelope formation	8/401	217/9376	0.86199248422722	KRT7/COL4A1/PPP2CA/KRT18/KRT8/CLDN7/DSP/PRSS8	-0.43475959113619
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/401	86/9376	0.815635330278954	ATF4/PRKACA/ATF6B	-0.363044334897173
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/401	29/9376	0.806260211540115	CALM2	-0.220862658132055
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/401	59/9376	0.792594784225876	TXNDC12/GSTM3	-0.337791119391235
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/401	30/9376	0.779384871155445	PCK2	-0.255813598013096
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/401	30/9376	0.779384871155445	B3GALT4	-0.255813598013096
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/401	115/9376	0.813271169901334	DUSP1/GNG10/PRKACA/HRAS	-0.425865001431872
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/401	60/9376	0.779384871155445	HRAS/PPP2CA	-0.362357097547073
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/401	31/9376	0.754243423698817	SHMT1	-0.289692290812705
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/401	31/9376	0.754243423698817	BAG6	-0.289692290812705
NA	NA	hsa04981	Folate transport and metabolism	1/401	31/9376	0.754243423698817	SHMT1	-0.289692290812705
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/401	62/9376	0.754243423698817	MAML1/NRARP	-0.41036798515899
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/401	63/9376	0.742271305862328	LTC4S/PRXL2B	-0.433839251764337
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/401	33/9376	0.708531701050404	BCKDHA	-0.354524062921119
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/401	122/9376	0.766608069988962	ADIPOR2/PPP2CA/PCK2/PRKAG1	-0.548455756362145
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/401	65/9376	0.719432188758872	SPP1/HRAS	-0.479774271915351
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/401	66/9376	0.708531701050404	DHRS11/HSD17B8	-0.502260528774233
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/401	125/9376	0.748209476309227	TNF/HRAS/PPP2CA/SGPP1	-0.599019062385909
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/401	154/9376	0.75914110826829	NME2/AK6/NAPRT/SHMT1/ALAS1	-0.637017085951978
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/401	68/9376	0.687692533372451	DGAT1/DHRS4	-0.546322682782684
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/401	99/9376	0.708531701050404	PLCG2/PRKACA/CALM2	-0.616234120486901
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/401	37/9376	0.631933679315225	MIF	-0.474151741563434
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/401	38/9376	0.615303845649035	HEXB	-0.502253884425099
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/401	38/9376	0.615303845649035	SGK1	-0.502253884425099
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/401	101/9376	0.694501370336535	PRKACA/HRAS/CALM2	-0.652459546859952
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/401	39/9376	0.599526823965727	SHMT1	-0.529715464678495
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/401	103/9376	0.681015906834855	COL4A1/SLC3A2/SLC1A5	-0.6880469989067
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/401	134/9376	0.697956601034727	PRKACA/ADM/ADORA2A/CALM2	-0.744353717713688
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/401	42/9376	0.556703479396746	AOC1	-0.60859119586438
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/401	44/9376	0.531398775787803	POLD4	-0.658541256421687
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/401	79/9376	0.59193787682692	ATP6V0C/NSF	-0.769855135083298
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	7/401	232/9376	0.705477685097601	FN1/CDC42/ACTN4/ARPC1B/HRAS/RGCC/PIP4K2B	-0.96014026952385
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/401	48/9376	0.487115544472153	BCKDHA	-0.752985273471588
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/401	86/9376	0.543756886852636	LMNA/DSP	-0.89841767305318
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/401	87/9376	0.53750680769341	MT-CO3/TPM1	-0.916054020733354
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/401	51/9376	0.458461688914967	PLPP2	-0.819653787195524
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/401	183/9376	0.638840058324135	CSNK2B/FBL/AK6/NXF1/NOP56	-1.04288659434102
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/401	52/9376	0.449645117974295	PRKACA	-0.841170354930185
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/401	53/9376	0.441161247823837	PRKACA	-0.86235721805695
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/401	90/9376	0.51958991410363	PRKACA/CA2	-0.967964940417241
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/401	91/9376	0.513880134827766	GNG10/PRKACA	-0.984948916501094
Organismal Systems	Immune system	hsa04611	Platelet activation	3/401	126/9376	0.556703479396746	PLCG2/PRKACA/FCGR2A	-1.05888628844263
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/401	93/9376	0.502828949132545	PRKACA/CALM2	-1.01845941584907
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/401	56/9376	0.41752760954756	MGAT4B	-0.924063885934851
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/401	57/9376	0.410202563766023	HSD17B8	-0.94405272085641
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/401	254/9376	0.644373318671824	PLCG2/FLT1/PRKACA/ADORA2A/CALM2/PPIF/VEGFA	-1.21452583452012
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/401	59/9376	0.396297392112938	NME2	-0.983222041627269
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/401	59/9376	0.396297392112938	PRKACA	-0.983222041627269
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/401	195/9376	0.599526823965727	PLCG2/GSDMD/NCF4/PPIF/FCGR2A	-1.19450051113842
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/401	226/9376	0.62074901242469	JUN/NFKBIA/FOS/PRKACA/ADORA2A/CALM2	-1.21986280336188
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/401	166/9376	0.563410750232852	ATF4/ATF6B/CALM2/PPIF	-1.19960388223908
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/401	63/9376	0.371135652931164	EHMT2	-1.0585784353832
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/401	70/9376	0.334022087638048	GSTM3	-1.18213729091281
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/401	73/9376	0.320295152529635	GSTM3	-1.2322842072483
NA	NA	hsa04081	Hormone signaling	5/401	219/9376	0.533825254216058	CSH1/GNG10/ADIPOR2/PRKACA/DIO2	-1.47548496643213
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/401	116/9376	0.403130105770058	SHMT1/TPI1	-1.36723690034372
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/401	116/9376	0.403130105770058	GNG10/PRKACA	-1.36723690034372
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/401	79/9376	0.29596893841346	GSTM3	-1.32823385764391
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/401	86/9376	0.271878443426318	PRKACA	-1.43379101120919
NA	NA	hsa04519	Cadherin signaling	10/401	404/9376	0.578751141947113	YWHAE/NFKBIA/CDC42/ACTN4/KRT7/ARPC1B/HRAS/KRT18/KRT8/DSP	-1.82947038046066
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/401	102/9376	0.229230844457484	CA2	-1.65436549259426
NA	NA	hsa04082	Neuroactive ligand signaling	3/401	199/9376	0.352485620120553	GNG10/PRKACA/ADORA2A	-1.9514893513991
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/401	370/9376	0.315966839657613	CSH1/ADM/CHRNB1/ADORA2A/LTB4R	-2.83760958487133
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/401	449/9376	0.156224138984388	PRKACA/CALM2/OR11G2	-3.87291616196278