category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	116/1247	238/9376	3.66464725425054	RPS2/RPS4Y1/RPS10/RPL36A/RPS16/RPL13A/RPL27A/RPLP2/RPS18/RPL17/RPS9/RPS3/RPL7A/RPLP1/RPL26/RPS17/RPLP0/RPL18A/RPL23A/RPL32/RPSA/RPS11/RPS19/RPS25/RPL13/RPL18/RPL23/RPS14/RPS15A/RPS29/RPL29/NFKBIA/RPS20/RPL31/RPS24/RPS8/RPL28/RPS13/RPS23/RPS7/RPS12/RPL11/RPL27/RPS27/RPL10A/RPS3A/RPL37/RPL19/RPL15/F13A1/RPS5/RPL3/RPL14/RPS6/RPS28/RPL39/RPL5/RPL8/RPL24/RPL7/C1QA/RPL4/NRP1/RPL21/RPL34/RPS27A/RPL30/IL6ST/UBA52/RPS15/RPL9/RPL6/RPL10/OAS3/RPS4X/C1QC/IRF9/PIK3R2/RPL38/JUN/MX1/ISG15/C1QB/RPL12/RPL22L1/RPL35A/IFNAR2/PIK3CB/C2/RPL36/FAU/RPL22/NFKBIB/FCGR2A/CXCL8/RPS26/TNF/HBEGF/RPS21/RPL35/OAS1/PLCG2/RPL37A/OAS2/FOS/C3AR1/RPL41/MX2/TLR4/CFB/AGTR1/CYBB/C1R/EIF2AK2/TLR7/TLR3	16.3080836386913
Genetic Information Processing	Translation	hsa03010	Ribosome	105/1247	222/9376	3.55621058107024	RPS2/RPS4Y1/RPS10/RPL36A/RPS16/RPL13A/RPL27A/RPLP2/RPS18/RPL17/RPS9/RPS3/RACK1/RPL7A/RPLP1/RPL26/RPS17/RPLP0/RPL18A/RPL23A/RPL32/RPSA/RPS11/RPS19/RPS25/RPL13/RPL18/RPL23/RPS14/RPS15A/RPS29/RPL29/RPS20/RPL31/RPS24/RPS8/RPL28/RPS13/RPS23/RPS7/RPS12/RPL11/RPL27/RPS27/RPL10A/RPS3A/RPL37/RPL19/RPL15/RPS5/RPL3/RPL14/RPS6/RPS28/RPL39/RPL5/RPL8/RPL24/RPL7/RPL4/RPL21/RPL34/RPS27A/RPL30/UBA52/MRPL38/MRPS12/RPS15/RPL9/RPL6/MRPS18B/RPL10/MRPL46/RPS4X/MRPL4/MRPS24/RPL38/MRPS17/RPL12/RPL22L1/RPL35A/RPL36/MRPL11/FAU/RPL22/MRPS25/RPS26/MRPL27/MRPL15/MRPS28/MRPL45/RPS21/RPL35/MRPS5/RPL37A/RPL41/MRPL23/MRPL12/MRPS2/MRPS35/MRPL16/MRPL32/MRPL10/MRPS22/MRPL44	15.0962112508412
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	80/1247	268/9376	2.24443141150702	PPIF/TUBB/SLC25A6/SLC39A1/SLC25A5/UBB/PSMB3/NDUFA7/PSMA2/RPS27A/PSMB4/UBA52/SLC39A7/ATP5MC3/NDUFA6/PSMC4/ATP5F1B/ATP5F1A/TUBA1C/GNAS/NDUFA13/PSMA4/SDHD/NDUFA3/CAMK2G/PSMB1/PSMA6/NDUFS1/DAXX/PSMB2/ATP5PB/SLC39A4/PSMA5/NDUFS3/PSMD11/CYC1/PSMA1/NDUFA11/PSMA3/PARK7/NDUFC2/ATP5F1C/NDUFB9/BAX/SEM1/TP53/PRKACA/ADRM1/PSMB6/COX4I2/CYCS/COX4I1/GNAI1/TUBB3/PSMD3/HSPA5/UQCRC2/TXN2/UQCRFS1/ITPR2/COX5A/PSMD7/MT-CO3/SDHA/PSMC1/PSMD13/UQCRH/ATP5MC2/PSMD6/NDUFB8/DDIT3/ATP5PO/CALML4/NDUFA10/NDUFA9/PSMA7/UQCR10/CALM3/PSMB7/ATP5MC1	8.09519200704698
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	27/1247	46/9376	4.4132352428437	PSME1/PSMB3/PSME2/PSMA2/PSMB8/PSMB4/PSMC4/PSMA4/PSMB1/PSMA6/PSMB2/PSMA5/PSMD11/PSMA1/PSMA3/PSMB10/SEM1/ADRM1/PSMB6/PSMD3/PSMD7/PSMC1/PSMD13/PSMB9/PSMD6/PSMA7/PSMB7	9.08875964144153
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	80/1247	275/9376	2.1873004301232	PPIF/TUBB/SLC25A6/SLC25A5/HSPA1A/HSPA1B/CSNK2B/PSMB3/C1QA/NDUFA7/PSMA2/HSPA8/PSMB4/ATP5MC3/NDUFA6/PSMC4/ATP5F1B/ATP5F1A/TUBA1C/NDUFA13/PSMA4/SDHD/NDUFA3/PSMB1/PSMA6/NDUFS1/ATF6B/C1QC/PSMB2/ATP5PB/PIK3R2/PSMA5/NDUFS3/PSMD11/C1QB/CYC1/PSMA1/PIK3CB/NDUFA11/PSMA3/NDUFC2/ATP5F1C/NDUFB9/BAX/TNF/SEM1/HSPA6/PRKACA/ADRM1/PSMB6/EGR1/COX4I2/CYCS/COX4I1/TUBB3/PSMD3/HSPA5/UQCRC2/UQCRFS1/ITPR2/COX5A/PSMD7/MT-CO3/SDHA/PSMC1/PSMD13/UQCRH/ATP5MC2/PSMD6/NDUFB8/DDIT3/ATP5PO/NDUFA10/NDUFA9/PSMA7/UQCR10/CYBB/PSMB7/CCL5/ATP5MC1	7.82677263730779
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	55/1247	158/9376	2.61731954158334	CCNE1/YWHAE/SKP2/CDKN1C/E2F4/CDC20/MYC/PTTG1/MCM5/CCNB2/CDK7/CDK1/ORC6/E2F3/MCM7/CCNB1/CCNA2/AURKB/CDT1/MCM3/MAD2L1/SGO1/MCM2/CDC6/MCM6/KNL1/TFDP2/TTK/BUB1/PKMYT1/CHEK1/PPP2CA/MDM2/TP53/CDCA5/PLK1/CDC45/HDAC1/MAD1L1/CDKN1B/BUB1B/TICRR/ESCO2/SKP1/NDC80/CDK2/MCM4/ANAPC4/CDC25A/TGFB1/E2F2/TRIP13/E2F5/E2F1/RAD21	8.02982959087516
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	34/1247	82/9376	3.1175699728128	HSPA1A/HSPA1B/CANX/CTSL/HLA-E/HSP90AB1/PSME1/HLA-G/LGMN/TAPBP/PSME2/IFI30/HSP90AA1/TAP1/HSPA8/HLA-C/B2M/HLA-B/HLA-A/TAP2/HSPA2/HLA-DRA/CALR/HLA-DRB1/NFYB/PDIA3/TNF/HSPA6/HSPA5/HLA-DPB1/HLA-DPA1/HLA-F/HLA-DMA/CD4	7.5429923162082
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	61/1247	205/9376	2.23731492166566	CCNE1/NFKBIA/SKP2/HLA-E/HLA-G/TAPBP/TAP1/HLA-C/B2M/HLA-B/PSMC4/MYC/IRF7/HLA-A/TAP2/OAS3/E2F3/HLA-DRA/CCNA2/IRF9/PIK3R2/CALR/JUN/PSMD11/ISG15/IFNAR2/PIK3CB/NFKBIB/HLA-DRB1/ICAM1/BAX/PDIA3/TNF/SEM1/MDM2/BCL2/TP53/ADRM1/CYCS/OAS1/HDAC1/PSMD3/PLCG2/MAP2K3/CDKN1B/HLA-DPB1/OAS2/PSMD7/CDK2/AKT3/PSMC1/PSMD13/NFKBIE/E2F2/HLA-DPA1/PSMD6/BAK1/HLA-F/E2F1/HLA-DMA/EIF2AK2	7.0153466768681
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	60/1247	224/9376	2.01397640050407	CCNE1/MSX2/SLC25A6/NFKBIA/SLC25A5/CANX/HLA-E/HLA-G/NRP1/HLA-C/CDC20/B2M/HLA-B/MYC/PTTG1/HLA-A/GPS2/CCNB2/ATF6B/E2F3/HLA-DRA/CCNA2/PIK3R2/CALR/JUN/RAN/HRAS/MAD2L1/PIK3CB/RANBP1/HLA-DRB1/NFYB/CHEK1/ICAM1/BAX/TNF/ADCY2/TP53/PRKACA/EGR1/MAD1L1/IL2RB/BUB1B/HLA-DPB1/FOS/CDK2/AKT3/ANAPC4/TGFB1/EGR2/E2F2/KAT2A/ITGB2/HLA-DPA1/HLA-F/ZFP36/E2F1/HLA-DMA/CD4/SPI1	6.01581058976177
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	51/1247	180/9376	2.13033948142208	NFKBIA/SRSF3/HLA-E/HLA-G/TAPBP/TAP1/HLA-C/B2M/HLA-B/ITGA5/IRF7/HLA-A/TAP2/SRSF6/OAS3/DAXX/SRSF2/HLA-DRA/IRF9/PIK3R2/CALR/SRSF5/SRSF7/IFNGR2/IFNAR2/PIK3CB/HLA-DRB1/TNFRSF14/BAX/PDIA3/TNF/BCL2/TP53/CYCS/OAS1/NECTIN1/BST2/HLA-DPB1/OAS2/AKT3/PPP1CC/SRSF9/HLA-DPA1/SRSF1/BAK1/NXF1/HLA-F/HLA-DMA/EIF2AK2/CCL5/TLR3	5.99716463997505
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	74/1247	308/9376	1.80647580166425	GPX3/PPIF/TUBB/SLC25A6/SLC25A5/PPARG/PSMB3/NDUFA7/PSMA2/TGM2/PSMB4/ATP5MC3/NDUFA6/PSMC4/ATP5F1B/POLR2J3/ATP5F1A/TUBA1C/NDUFA13/PSMA4/SDHD/NDUFA3/CLTA/TFAM/PSMB1/PSMA6/NDUFS1/POLR2A/AP2M1/PSMB2/ATP5PB/PSMA5/NDUFS3/PSMD11/CYC1/PSMA1/NDUFA11/PSMA3/NDUFC2/ATP5F1C/SLC1A3/NDUFB9/BAX/SEM1/TP53/ADRM1/PSMB6/COX4I2/CYCS/COX4I1/TUBB3/HDAC1/PSMD3/UQCRC2/UQCRFS1/COX5A/PSMD7/MT-CO3/SDHA/TAF4B/PSMC1/PSMD13/UQCRH/ATP5MC2/PSMD6/NDUFB8/ATP5PO/NDUFA10/NDUFA9/PSMA7/UQCR10/TAF4/PSMB7/ATP5MC1	5.63652252098276
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	84/1247	368/9376	1.71625814999477	GPX3/HNRNPA1/HNRNPA2B1/TUBB/SRSF3/PSMB3/HNRNPA3/NDUFA7/PSMA2/PSMB4/ATP5MC3/NDUFA6/PSMC4/ATP5F1B/SQSTM1/ATP5F1A/TUBA1C/CHCHD10/NDUFA13/PSMA4/SDHD/NDUFA3/PSMB1/PSMA6/NDUFS1/DAXX/PSMB2/ATP5PB/PSMA5/NDUFS3/PSMD11/SRSF7/PFN1/CYC1/TOMM40/PSMA1/FUS/NDUFA11/PSMA3/NDUFC2/ATP5F1C/NDUFB9/BAX/TNF/SEM1/VCP/BCL2/TP53/ADRM1/CAT/PSMB6/SMCR8/COX4I2/CYCS/COX4I1/TUBB3/PSMD3/HSPA5/UQCRC2/NUP210/UQCRFS1/COX5A/MAP2K3/HNRNPA1L3/PSMD7/MT-CO3/SDHA/PSMC1/PSMD13/UQCRH/ATP5MC2/NUP37/PSMD6/NDUFB8/DDIT3/ATP5PO/RAB8A/NXF1/NDUFA10/NDUFA9/PSMA7/UQCR10/PSMB7/ATP5MC1	5.49009172462641
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	87/1247	388/9376	1.68592663629825	PPIF/TUBB/SLC25A6/SLC39A1/SLC25A5/CSNK2B/BACE2/PSMB3/NDUFA7/PSMA2/MME/PSMB4/SLC39A7/ATP5MC3/NDUFA6/PSMC4/ATP5F1B/ATP5F1A/TUBA1C/CTNNB1/NDUFA13/PSMA4/SDHD/NDUFA3/PSMB1/PSMA6/NDUFS1/PSMB2/ATP5PB/PIK3R2/SLC39A4/PSMA5/NDUFS3/AXIN2/PSMD11/HRAS/CYC1/PSMA1/PIK3CB/NDUFA11/PSMA3/NDUFC2/ATP5F1C/NDUFB9/TNF/SEM1/CASP7/ADRM1/PSMB6/COX4I2/CYCS/COX4I1/TUBB3/LRP6/PSMD3/FZD10/UQCRC2/UQCRFS1/ITPR2/IRS1/COX5A/PSMD7/MT-CO3/AKT3/FZD5/SDHA/PSMC1/PSMD13/FRAT2/UQCRH/ATP5MC2/APOE/PSMD6/NDUFB8/DDIT3/ATP5PO/CALML4/NDUFA10/NDUFA9/PSMA7/UQCR10/CALM3/CYBB/PSMB7/EIF2AK2/WNT6/ATP5MC1	5.40458438394981
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	43/1247	157/9376	2.05930155941138	CCNE1/SLC25A6/SLC25A5/HLA-E/HLA-G/HLA-C/E2F4/HLA-B/MYC/SQSTM1/HLA-A/CCNB2/CDK1/E2F3/CCNB1/CCNA2/PIK3R2/RAD50/HRAS/PIK3CB/CXCL8/CHEK1/MDM2/TP53/MYBL2/SERPINE1/ITPR2/RBBP4/MAP2K3/LIN9/CDK2/AKT3/PPP1CC/CDC25A/TGFB1/E2F2/LIN37/E2F5/CALML4/HLA-F/FOXM1/CALM3/E2F1	5.2423719776222
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	39/1247	138/9376	2.12489104285067	ATP6V0C/ATP6V1C2/ATP5MG/NDUFA7/ATP5MC3/NDUFA6/ATP5F1B/ATP5F1A/NDUFA13/SDHD/NDUFA3/NDUFS1/ATP6V0A4/ATP5PB/NDUFS3/CYC1/NDUFA11/NDUFC2/ATP5F1C/ATP6V1B2/PPA1/NDUFB9/COX4I2/CYCS/COX4I1/UQCRC2/UQCRFS1/COX5A/MT-CO3/ATP6V1B1/SDHA/UQCRH/ATP5MC2/NDUFB8/ATP5PO/NDUFA10/NDUFA9/UQCR10/ATP5MC1	5.21388353683285
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	42/1247	155/9376	2.03736451354218	TUBB/COLEC12/CANX/CTSL/HLA-E/ATP6V0C/ATP6V1C2/HLA-G/OLR1/TAP1/HLA-C/HLA-B/TUBA1C/ITGA5/MRC1/HLA-A/TAP2/TFRC/HLA-DRA/ATP6V0A4/CD14/CALR/SCARB1/HLA-DRB1/FCGR2A/ATP6V1B2/TUBB3/HLA-DPB1/RAB5C/ITGAM/CD36/ATP6V1B1/RILP/ITGB2/HLA-DPA1/FCGR3A/TLR4/HLA-F/CD209/CYBB/C1R/HLA-DMA	5.10045040131589
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	21/1247	56/9376	2.81956696070569	EEF1G/NFKBIA/HSPD1/HSPA1A/HSPA1B/HSPA8/EEF1A1/HSF1/CD14/CR1/CXCL8/TNF/VCP/HSPA6/CASP7/CYCS/PYCARD/ITGAM/ITGB2/TLR4/NAIP	5.34877590547485
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	51/1247	205/9376	1.87054198368768	CCNE1/ACTN4/NFKBIA/YWHAE/SKP2/HLA-E/HLA-G/DDB1/PMAIP1/HLA-C/CDC20/IL6ST/HLA-B/CDC42/IRF7/MRPS18B/HLA-A/ATF6B/CDK1/CCNA2/IRF9/PIK3R2/JUN/HRAS/GTF2H1/PIK3CB/RANBP1/ACTN1/DNAJA3/GRB2/CHEK1/BAX/HNRNPK/MDM2/TP53/PRKACA/SCRIB/GTF2H4/HDAC1/EGR3/MAD1L1/CDKN1B/CDK2/PSMC1/EGR2/GTF2B/KAT2A/GTF2H2/BAK1/HLA-F/EIF2AK2	4.9358119791493
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	50/1247	205/9376	1.83386468988988	PPIF/SLC25A6/SLC25A5/NDUFA7/PARP1/ATP5MC3/NDUFA6/ATP5F1B/ATP5F1A/NDUFA13/SDHD/NDUFA3/CAMK2G/NDUFS1/CPT2/ATP5PB/PIK3R2/NDUFS3/GSR/CYC1/PIK3CB/NDUFA11/NDUFC2/ATP5F1C/NDUFB9/TBC1D4/PDK4/COX4I2/COX4I1/UQCRC2/UQCRFS1/IRS1/COX5A/CD36/MT-CO3/AKT3/PPP1CC/SDHA/UQCRH/TGFB1/ATP5MC2/NDUFB8/ATP5PO/NDUFA10/NDUFA9/UQCR10/AGTR1/CYBB/PDK3/ATP5MC1	4.72785850937743
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	41/1247	157/9376	1.96352009153178	PPARG/CEBPA/NDUFA7/NDUFA6/CDC42/NDUFA13/SDHD/NDUFA3/ADIPOR2/NDUFS1/PIK3R2/NDUFS3/JUN/PRKAG1/CYC1/PIK3CB/NDUFA11/NDUFC2/CXCL8/NDUFB9/BAX/TNF/CASP7/COX4I2/CYCS/COX4I1/UQCRC2/UQCRFS1/IRS1/COX5A/FOS/MT-CO3/AKT3/SDHA/UQCRH/TGFB1/NDUFB8/DDIT3/NDUFA10/NDUFA9/UQCR10	4.76835956942132
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	24/1247	75/9376	2.40603047313553	CCNE1/PMAIP1/SIAH1/ZNF385A/STEAP3/CCNB2/CDK1/SHISA5/CCNB1/SESN2/CHEK1/BAX/MDM2/BCL2/TP53/RRM2/GTSE1/CCNG1/CYCS/SERPINE1/SIVA1/CDK2/AIFM2/IGF1	4.78807391354507
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	15/1247	36/9376	3.13285217856188	MCM5/SSBP1/MCM7/MCM3/FEN1/POLD4/MCM2/MCM6/POLD1/RNASEH2C/MCM4/POLE2/POLA2/RFC4/DNA2	5.02156249853796
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	95/1247	480/9376	1.48810478481689	GPX3/PPIF/TUBB/SLC25A6/SLC25A5/UBB/CSNK2B/PSMB3/NDUFA7/PSMA2/RPS27A/PSMB4/UBA52/ATP5MC3/NDUFA6/PSMC4/ATP5F1B/SQSTM1/ATP5F1A/TUBA1C/CTNNB1/NDUFA13/PSMA4/SDHD/NDUFA3/CAMK2G/PSMB1/PSMA6/NDUFS1/DAXX/PSMB2/ATP5PB/PSMA5/NDUFS3/AXIN2/PSMD11/HRAS/CYC1/TOMM40/PSMA1/FUS/NDUFA11/PSMA3/PARK7/NDUFC2/ATP5F1C/NDUFB9/BAX/TNF/SEM1/VCP/BCL2/CASP7/ADRM1/CAT/PSMB6/SMCR8/COX4I2/CYCS/COX4I1/TUBB3/LRP6/PSMD3/HSPA5/FZD10/UQCRC2/UQCRFS1/ITPR2/COX5A/MAP2K3/PSMD7/MT-CO3/FZD5/SDHA/PSMC1/PSMD13/FRAT2/UQCRH/ATP5MC2/PSMD6/NDUFB8/DDIT3/ATP5PO/RAB8A/BAK1/CALML4/NDUFA10/NDUFA9/PSMA7/UQCR10/CALM3/CYBB/PSMB7/WNT6/ATP5MC1	4.29968460312347
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/1247	227/9376	1.7223786426631	PPIF/SLC25A6/NFKBIA/SLC25A5/MGST3/NDUFA7/GSTA3/GSTA4/HMOX1/ATP5MC3/NDUFA6/ATP5F1B/ATP5F1A/NDUFA13/SDHD/NDUFA3/NDUFS1/ATP5PB/PIK3R2/NDUFS3/JUN/HRAS/CYC1/PIK3CB/NDUFA11/NDUFC2/ATP5F1C/GRB2/NDUFB9/GSTO1/CAT/GSTT1/EPHX2/COX4I2/COX4I1/UQCRC2/UQCRFS1/COX5A/EPHX1/CBR1/FOS/MT-CO3/AKT3/SDHA/UQCRH/ATP5MC2/NDUFB8/ATP5PO/NDUFA10/NDUFA9/UQCR10/ATP5MC1	4.31510447826847
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	53/1247	235/9376	1.69573956218328	PPARG/ATP5MG/RPS6/NDUFA7/FGFR1/ATP5MC3/NDUFA6/ATP5F1B/ATP5F1A/SMARCB1/GNAS/NDUFA13/SDHD/NDUFA3/NDUFS1/CPT2/ATP5PB/NDUFS3/HRAS/PRKAG1/CYC1/NDUFA11/NDUFC2/SMARCE1/ATP5F1C/GRB2/NDUFB9/ADCY2/PRKACA/COX4I2/COX4I1/UQCRC2/COA4/UQCRFS1/RPS6KA1/COX5A/MAP2K3/MGLL/SLC25A29/MT-CO3/SDHA/COX16/UQCRH/ATP5MC2/NDUFAF4/COA7/NDUFB8/ATP5PO/KDM1A/NDUFA10/NDUFA9/UQCR10/ATP5MC1	4.23042577360235
Human Diseases	Infectious disease: viral	hsa05162	Measles	35/1247	136/9376	1.93499693381763	CCNE1/RACK1/NFKBIA/HSPA1A/HSPA1B/CSNK2B/HSPA8/IRF7/OAS3/IRF9/PIK3R2/JUN/MX1/IFNAR2/PIK3CB/NFKBIB/EIF3H/BAX/BCL2/TP53/HSPA6/CYCS/OAS1/IL2RB/CDKN1B/OAS2/FOS/CDK2/AKT3/MX2/TLR4/BAK1/CD209/EIF2AK2/TLR7	4.30173802500639
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	51/1247	227/9376	1.68925597645804	NFKBIA/HLA-E/HLA-G/IL10RB/TAPBP/CCL4/TAP1/HLA-C/CCL3/B2M/HLA-B/MYC/GNG10/GNAS/CTNNB1/HLA-A/GNA12/TAP2/ATF6B/E2F3/PIK3R2/CALR/BCAR1/CCR1/HRAS/PIK3CB/GNG12/CXCL8/GRB2/GNG5/BAX/PDIA3/TNF/ADCY2/MDM2/TP53/PRKACA/CYCS/GNAI1/ITPR2/IL10RA/AKT3/CCL4L2/E2F2/CCL3L1/BAK1/CALML4/HLA-F/CALM3/E2F1/CCL5	4.11724734790436
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	49/1247	216/9376	1.70566396388369	NFKBIA/HSPD1/HSPA1A/HSPA1B/PPARG/HSP90AB1/OLR1/VAV3/HSP90AA1/CYP2J2/HSPA8/CCL3/CDC42/IRF7/CAMK2G/TNFSF10/HSPA2/PIK3R2/CD14/JUN/HRAS/PIK3CB/CXCL8/ABCA1/ICAM1/BAX/TICAM2/TNF/BCL2/TP53/HSPA6/CASP7/RXRB/CYCS/HSPA5/PYCARD/MAP2K3/LY96/FOS/CD36/AKT3/DDIT3/CCL3L1/TLR4/CALML4/CALM3/CYBB/ABCG1/CCL5	4.10939020857994
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	26/1247	93/9376	2.10204275206733	CCNE1/NFKBIA/SKP2/COL4A1/COL4A2/CKS2/MYC/E2F3/PIK3R2/CKS1B/PIK3CB/LAMB1/FN1/BAX/BCL2/TP53/RXRB/CYCS/CDKN1B/TRAF4/CDK2/AKT3/BIRC7/E2F2/BAK1/E2F1	4.18307879072729
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	23/1247	78/9376	2.21709538790533	C1QA/ITGA5/C1QC/CD14/IRF1/JUN/C1QB/C2/CXCL8/TICAM2/TNF/CASP7/GNAI1/PYCARD/CFL1/LY96/ITGAM/FOS/ITGB2/TLR4/CALML4/CALM3/C1R	4.22743997962006
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	12/1247	30/9376	3.00753809141941	GGH/SLC19A1/SHMT1/ABCG2/TYMS/FOLR2/ATIC/FOLR1/SHMT2/TNF/DHFR/GART	4.31332156397154
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	44/1247	196/9376	1.68790403089865	NFKBIA/HLA-E/UBB/HLA-G/HLA-C/RPS27A/IL6ST/UBA52/HLA-B/MYC/GNG10/TCF7L2/CTNNB1/IRF7/HLA-A/E2F3/IRF9/PIK3R2/JUN/CCR1/HRAS/IFNAR2/PIK3CB/GNG12/CXCL8/GNG5/ICAM1/BAX/TP53/CYCS/PLCG2/ITPR2/PREX1/FOS/AKT3/E2F2/BAK1/CALML4/HLA-F/ZFP36/CALM3/E2F1/EIF2AK2/TLR3	3.81184166291314
Genetic Information Processing	Transcription	hsa03040	Spliceosome	52/1247	243/9376	1.60897099540956	HNRNPA1/HSPA1A/HSPA1B/SRSF3/DDX5/DDX39B/HNRNPA3/HSPA8/PRPF8/PUF60/HNRNPU/RBM8A/HNRNPC/MAGOH/CWC25/SRSF6/PRPF31/SRSF2/SNRPG/LSM2/SRSF5/SRSF7/SNRPD1/FUS/EIF4A3/DHX16/SNRPD2/THOC3/HNRNPK/HSPA6/RBMX/SNRPF/THOC6/SNRPB/PRPF19/U2AF2/SNRPD3/HNRNPA1L3/LSM7/LSM6/SNRPE/RBM17/PPIL1/SNRNP40/SRSF9/PHF5A/PPIH/SRSF1/TRA2B/PRPF40A/HNRNPM/LSM8	3.76698004252024
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	47/1247	214/9376	1.65133516701767	NFKBIA/HLA-E/HLA-G/DDB1/TAPBP/TAP1/HLA-C/B2M/HLA-B/GNG10/HLA-A/TAP2/CCNB2/CDK1/CCNB1/PIK3R2/CALR/JUN/HRAS/PIK3CB/GNG12/GNG5/CHEK1/BAX/PDIA3/TNF/BCL2/LIMK2/CYCS/GNAI1/PLCG2/ITPR2/MAP2K3/BST2/SKP1/PAK6/CFL1/FOS/AKT3/TRIM5/TLR4/BAK1/CALML4/HLA-F/CALM3/AP1S3/CD4	3.77499667497784
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	25/1247	95/9376	1.97864348119698	FLT1/CTSL/ATP6V0C/ATP6V1C2/CCL3/HLA-DRA/ATP6V0A4/JUN/HLA-DRB1/ATP6V1B2/CXCL8/ICAM1/TNF/HLA-DPB1/FOS/ATP6V1B1/ANGPT1/TGFB1/ITGB2/HLA-DPA1/ACP5/CCL3L1/TLR4/HLA-DMA/CCL5	3.75482090429296
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	27/1247	106/9376	1.91517755821519	CCNE1/NFKBIA/HSP90AB1/ETV5/HSP90AA1/SLC19A1/FGFR1/TCF7L2/CTNNB1/E2F3/PIK3R2/HRAS/FOLR2/PIK3CB/FOLR1/GRB2/MDM2/BCL2/TP53/PDGFC/CDKN1B/CDK2/AKT3/E2F2/E2F1/NKX3-1/IGF1	3.71123735292801
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	39/1247	173/9376	1.69499979140689	SLC25A6/NFKBIA/SLC25A5/IRF7/TNFSF10/OAS3/DNAJB1/HLA-DRA/IRF9/PIK3R2/PABPN1/MX1/KPNA2/IFNGR2/IFNAR2/PIK3CB/NFKBIB/HLA-DRB1/CXCL8/ICAM1/BAX/TNF/CYCS/OAS1/CPSF4/PYCARD/HLA-DPB1/OAS2/AKT3/MX2/HLA-DPA1/TLR4/BAK1/NXF1/HLA-DMA/EIF2AK2/TLR7/CCL5/TLR3	3.61362696227552
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	28/1247	112/9376	1.87971130713713	PPIF/NFKBIA/HSPA1A/HSPA1B/IL10RB/HSPA8/HLA-DRA/IFNGR2/LAMB1/NFKBIB/HLA-DRB1/SOCS1/TNF/BCL2/HSPA6/CYCS/GNAI1/MAP2K3/HLA-DPB1/LY96/IL10RA/AKT3/BIRC7/TGFB1/HLA-DPA1/TLR4/ALOX5/HLA-DMA	3.66817642524249
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	39/1247	174/9376	1.68525841329536	HSPA1A/HSPA1B/CANX/HSP90AB1/DNAJA1/HSP90AA1/BAG2/P4HB/HSPA8/DDOST/MAN1A1/ATF6B/DNAJB1/RRBP1/TXNDC5/SSR2/CALR/PDIA6/HYOU1/RNF5/PDIA4/BAX/PDIA3/VCP/BCL2/HSPA6/HSPA5/LMAN2/TUSC3/SKP1/RPN2/PPP1R15A/ERP29/RAD23A/DDIT3/BAK1/DNAJA2/EDEM2/STT3B	3.57345394426112
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	21/1247	78/9376	2.02430448460922	NFKBIA/EEF1A1/HLA-DRA/JUN/CR1/MARCKSL1/IFNGR2/NFKBIB/HLA-DRB1/FCGR2A/TNF/HLA-DPB1/ITGAM/FOS/TGFB1/ITGB2/HLA-DPA1/FCGR3A/TLR4/CYBB/HLA-DMA	3.5578030880501
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	33/1247	144/9376	1.72306869820903	PPIF/SLC25A6/SLC25A5/PSMB3/PSMA2/PSMB4/PSMC4/PSMA4/PSMB1/PSMA6/PSMB2/PIK3R2/NOP56/PSMA5/PSMD11/PSMA1/PIK3CB/PSMA3/SEM1/ADRM1/PSMB6/CYCS/PSMD3/ITPR2/PSMD7/AKT3/PSMC1/PSMD13/GTF2B/PSMD6/PSMA7/PSMB7/TWNK	3.42462649677995
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	13/1247	39/9376	2.50628174284951	ALDH7A1/GLDC/SHMT1/TYMS/GCSH/MTHFS/ATIC/SHMT2/MAT2A/DHFR/CHDH/AHCY/GART	3.69177427689079
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	17/1247	59/9376	2.16644693025974	GPX3/MGST3/GSTA3/GSTA4/IDH2/IDH1/GSR/TXNDC12/PRDX6/RRM2/SMS/GSTO1/HPGDS/GSTT1/SRM/GSS/GCLM	3.52008577147715
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	34/1247	156/9376	1.63872267801698	NFKBIA/YWHAE/CLDN7/MYC/CTNNB1/IRF7/OAS3/CLDN19/E2F3/IRF9/PIK3R2/SCARB1/MX1/HRAS/IFNAR2/PIK3CB/GRB2/BAX/TNF/PPP2CA/TP53/CYCS/OAS1/CLDN23/OAS2/CDK2/AKT3/MX2/E2F2/BAK1/E2F1/EIF2AK2/IFIT1/TLR3	3.15071759306217
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/1247	42/9376	2.32726161836026	SLC40A1/SAT1/HMOX1/LPCAT3/STEAP3/TFRC/FTH1/TP53/SLC3A2/GSS/GCLM/NCOA4/CYBB	3.37635097603317
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	49/1247	248/9376	1.48557829112451	RPS3/TUBB/ARPC1B/NFKBIA/HSP90AB1/HSP90AA1/ARPC5/ARPC2/CDC42/MYC/TUBA1C/TCF7L2/CTNNB1/TNFSF10/DYNLRB1/GSDMD/CD14/JUN/PFN1/HRAS/PIK3CB/CYFIP2/CXCL8/BAX/TNF/BCL2/CASP7/SNX18/CYCS/TUBB3/TXN2/CASP4/PYCARD/MAP2K3/RAB5C/SKP1/LY96/FOS/PKN1/AKT3/RILP/TLR4/ELMO1/CYTH4/BAK1/VPS11/DYNLL2/NAIP/MLKL	3.03527182278813
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	30/1247	137/9376	1.64646245880624	NFKBIA/CTSL/PMAIP1/PARP1/BIRC5/TUBA1C/TNFSF10/DAXX/LMNB2/LMNB1/PIK3R2/JUN/HRAS/PIK3CB/CTSO/CTSH/BAX/TNF/DAB2IP/BCL2/TP53/CASP7/CYCS/DFFA/ITPR2/FOS/AKT3/DDIT3/AIFM1/BAK1	2.98532359095748
Human Diseases	Immune disease	hsa05330	Allograft rejection	12/1247	39/9376	2.31349083955339	HLA-E/HLA-G/HLA-C/HLA-B/HLA-A/HLA-DRA/HLA-DRB1/TNF/HLA-DPB1/HLA-DPA1/HLA-F/HLA-DMA	3.21925942302241
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/1247	44/9376	2.22147699934388	HSPD1/HLA-E/HLA-G/HLA-C/HLA-B/HLA-A/HLA-DRA/HLA-DRB1/TNF/HLA-DPB1/HLA-DPA1/HLA-F/HLA-DMA	3.18071362968936
NA	NA	hsa04981	Folate transport and metabolism	10/1247	31/9376	2.42543394469307	SLC19A1/SHMT1/ABCG2/TYMS/MTHFS/FOLR2/FOLR1/SHMT2/DHFR/SLCO2B1	3.11342633019372
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	40/1247	201/9376	1.49628760767135	HPGD/FLT1/MLLT1/PPARG/CEBPA/ETV5/CEBPB/DDX5/CSF1R/MYC/NUPR1/MAF/CCNA2/CD14/ID2/TAF15/FUS/SIX4/CXCL8/BAX/MDM2/MYCN/TP53/RXRB/NR4A3/HDAC1/FUT8/IL2RB/ETV7/CDKN1B/ITGAM/HHEX/DDIT3/MEF2C/BAK1/RUNX1/SS18/SPI1/DUSP6/IGF1	2.78566396588453
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	48/1247	253/9376	1.42650028051513	FOXO4/ARPC1B/ACTN4/NFKBIA/UBB/CTTN/ARPC5/HCLS1/ARPC2/RPS27A/UBA52/CDC42/SQSTM1/ITGA5/CBX3/PIK3R2/CD14/BCAR1/SEPTIN3/JUN/PFN1/PIK3CB/ACTN1/RNF31/NFKBIB/CXCL8/BAX/TNF/MDM2/BCL2/TP53/FOXO6/ATG16L1/UBE2N/CYCS/PLCG2/SEPTIN6/CASP4/PYCARD/ITPR2/SKP1/AKT3/TLR4/ELMO1/CYTH4/ARHGEF2/NAIP/CCL5	2.69346320731671
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	24/1247	109/9376	1.65552555490977	SPP1/NFKBIA/CCL4/CCL3/IRF7/IRF9/PIK3R2/CD14/JUN/IFNAR2/PIK3CB/CXCL8/TICAM2/TNF/MAP2K3/LY96/FOS/AKT3/CCL4L2/CCL3L1/TLR4/TLR7/CCL5/TLR3	2.6960851072923
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	18/1247	75/9376	1.80452285485164	PMAIP1/MGST3/GSTA3/GSTA4/BIRC5/TOP2A/PIK3R2/PIK3CB/BAX/MDM2/BCL2/TP53/GSTO1/GSTT1/CYCS/AKT3/BAK1/ATP7B	2.73970939305144
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	34/1247	170/9376	1.5037690457097	ARPC1B/ACTN4/CTTN/CLDN7/ARPC5/HCLS1/JAM3/ARPC2/CDC42/TUBA1C/CLDN19/MYH10/JUN/PRKAG1/ACTN1/TJP2/PPP2CA/PRKACA/TJP3/SCRIB/MARVELD2/CLDN23/ARHGAP17/MARVELD3/SYNPO/RAPGEF6/TJP1/MPDZ/VASP/RAB8A/RAP2C/ARHGEF2/JAM2/RUNX1	2.59609605456942
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1247	54/9376	1.9493302444385	LDHB/LDHA/DNMT1/CDO1/ADI1/MDH2/DNMT3A/MAT2A/SMS/PHGDH/SRM/AHCY/GSS/GCLM	2.74005923101909
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	22/1247	99/9376	1.670854495233	GNAS/E2F3/PIK3R2/JUN/HRAS/PIK3CB/GRB2/BAX/ADCY2/MDM2/BCL2/HBEGF/TP53/PRKACA/CDKN1B/NOTCH3/FOS/AKT3/E2F2/NCOA3/E2F1/IGF1	2.62810345020287
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	18/1247	77/9376	1.757652131349	NFKBIA/MYC/E2F3/PIK3R2/HRAS/PIK3CB/GRB2/BAX/MDM2/TP53/HDAC1/CDKN1B/AKT3/TGFB1/E2F2/BAK1/RUNX1/E2F1	2.61455264643882
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	12/1247	45/9376	2.0050253942796	HLA-E/HLA-G/HLA-C/HLA-B/HLA-A/HLA-DRA/HLA-DRB1/TNF/HLA-DPB1/HLA-DPA1/HLA-F/HLA-DMA	2.64679009471397
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	15/1247	62/9376	1.8190754585198	HSPA1A/HSPA1B/HSPA8/PIK3R2/HRAS/PRKAG1/PIK3CB/ADCY2/HSPA6/PRKACA/CAT/HDAC1/IRS1/AKT3/IGF1	2.5342645274489
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	32/1247	163/9376	1.47609231480707	CCNE1/NFKBIA/DDB1/BIRC5/MYC/IRF7/ATF6B/E2F3/CCNA2/PIK3R2/JUN/HRAS/PIK3CB/CXCL8/GRB2/BAX/TICAM2/TNF/BCL2/TP53/CYCS/EGR3/MAP2K3/FOS/CDK2/AKT3/TGFB1/EGR2/E2F2/TLR4/E2F1/TLR3	2.4015118880023
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	31/1247	157/9376	1.48461275213378	CD24/PPARG/CEBPB/RAB17/SLC16A1/C1QA/BSG/STAB1/CAMK2G/ARG2/SIRPA/C1QC/CALR/BCAR1/C1QB/DUSP16/P2RY6/ABCA1/DNMT3A/DUSP5/CASP7/UQCRFS1/RAB5C/CD36/PLA2G15/TGFB1/DUSP8/XKR8/ELMO1/VPS11/ALOX5	2.39829752841694
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	22/1247	103/9376	1.60596694202007	NFKBIA/C1QA/CCL3/GNAS/C1QC/PIK3R2/CALR/JUN/C1QB/IFNGR2/PIK3CB/CXCL8/TNF/PPP2CA/GNAI1/SERPINE1/FOS/AKT3/TGFB1/CCL3L1/TLR4/CCL5	2.42190842457205
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	22/1247	103/9376	1.60596694202007	SERPINB9/ACTN4/SERPINB6/COL4A1/COL4A2/GNAS/ARG2/PRDX1/PIK3R2/CD14/PIK3CB/LAMB1/FN1/ACTN1/CXCL8/TNF/PRKACA/RAB5C/ITGAM/TGFB1/ITGB2/TLR4	2.42190842457205
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	24/1247	115/9376	1.56915030856665	GCM1/MMP14/FGFR1/GNAS/MMP15/GNA12/ATF6B/ARRB1/WNK2/ADCY2/PDE4B/BCL2/HBEGF/SLC34A2/PRKACA/EGR1/RXRB/GNAI1/LRP6/ITPR2/JUND/FOS/MEF2C/NACA	2.40517818912394
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1247	31/9376	2.18289055022376	ACSS1/GLDC/GLUL/SHMT1/GCSH/MDH2/SHMT2/CAT/AFMID	2.58366415260091
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	23/1247	110/9376	1.57212218415105	HSP90AB1/HSP90AA1/CCNB2/CDK1/CCNB1/CCNA2/PIK3R2/MAD2L1/PIK3CB/BUB1/PKMYT1/ADCY2/PRKACA/PLK1/GNAI1/MAD1L1/RPS6KA1/AURKA/CDK2/AKT3/ANAPC4/CDC25A/IGF1	2.36395543900194
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	58/1247	333/9376	1.30958865842587	CCNE1/SPP1/HLA-E/ATP6V0C/ATP6V1C2/HLA-G/HLA-C/COL4A1/COL4A2/HLA-B/CDC42/GNAS/TCF7L2/CTNNB1/ITGA5/HLA-A/ATP6V0A4/CCNA2/IRF9/PIK3R2/IRF1/AXIN2/MX1/ISG15/HRAS/IFNAR2/PIK3CB/LAMB1/FN1/ATP6V1B2/GRB2/MAML1/BAX/TNF/PPP2CA/MDM2/TP53/PRKACA/HEY1/SCRIB/HDAC1/FZD10/CDKN1B/PPP2R3B/NOTCH3/CDK2/AKT3/FZD5/ATP6V1B1/PSMC1/MX2/BAK1/HLA-F/E2F1/COL2A1/EIF2AK2/TLR3/WNT6	2.2529481492142
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	19/1247	87/9376	1.6420466591083	PMAIP1/BIRC5/MYC/TCF7L2/CTNNB1/PIK3R2/JUN/AXIN2/HRAS/PIK3CB/GRB2/BAX/BCL2/TP53/CYCS/FOS/AKT3/TGFB1/BAK1	2.35636215218389
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	16/1247	70/9376	1.7185931950968	HLA-E/HLA-G/HLA-C/HLA-B/HLA-A/HLA-DRA/SSPN/HLA-DRB1/ICAM1/CYCS/HLA-DPB1/ITGB2/HLA-DPA1/HLA-F/SNTB1/HLA-DMA	2.36347438202532
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1247	37/9376	2.03212033204014	PPARG/MYC/TCF7L2/CTNNB1/HRAS/BAX/TP53/RXRB/NCOA4/BAK1	2.46366305516745
Human Diseases	Cancer: specific types	hsa05214	Glioma	17/1247	76/9376	1.68184695901743	CAMK2G/E2F3/PIK3R2/HRAS/PIK3CB/GRB2/BAX/MDM2/TP53/PLCG2/AKT3/E2F2/BAK1/CALML4/CALM3/E2F1/IGF1	2.33750491621167
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/1247	59/9376	1.78413276609626	CGA/GNAS/ADRB1/PIK3R2/PIK3CB/PLAAT3/ADCY2/PRKACA/GNAI1/IRS1/MGLL/AKT3/FABP4/NPY1R	2.36634391268004
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	37/1247	200/9376	1.39098636728148	RPS3/TUBB/ARPC1B/NFKBIA/CTTN/CLDN7/ARPC5/HCLS1/ARPC2/NCL/CDC42/TUBA1C/GNA12/TNFSF10/CLDN19/MYH10/JUN/CYFIP2/NFKBIB/FCGR2A/CXCL8/BAX/TNF/CASP7/CYCS/WIPF1/TUBB3/CLDN23/CASP4/PYCARD/FOS/TJP1/TLR4/CYTH4/ARHGEF2/BAK1/NAIP	2.18902243916508
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	34/1247	181/9376	1.41237976668867	HSPD1/CEBPB/ATP6V0C/IL10RB/CAMK2G/MRC1/HLA-DRA/ATP6V0A4/CD14/CR1/IFNGR2/HLA-DRB1/FCGR2A/NFYB/BAX/TNF/BCL2/CYCS/KSR1/HLA-DPB1/RAB5C/LSP1/ITGAM/IL10RA/AKT3/TGFB1/ITGB2/HLA-DPA1/FCGR3A/TLR4/CALML4/CD209/CALM3/HLA-DMA	2.19412351746717
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/1247	101/9376	1.56332425544078	COL4A1/COL4A2/CDC42/PIK3R2/JUN/HRAS/PIK3CB/FN1/CXCL8/ICAM1/BAX/TNF/BCL2/EGR1/SERPINE1/PLCG2/CDKN1B/AKT3/TGFB1/AGTR1/CYBB	2.22926902800256
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	27/1247	138/9376	1.47107841428123	CCNE1/YWHAE/CDC20/PTTG1/CAMK2G/CCNB2/CDK1/CCNB1/MAD2L1/SGO1/BUB1/PKMYT1/PPP2CA/ADCY2/PRKACA/PLK1/MAD1L1/RPS6KA1/ITPR2/AURKA/SKP1/CDK2/ANAPC4/PPP1CC/CALML4/CALM3/IGF1	2.18345412596933
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	27/1247	138/9376	1.47107841428123	ARPC1B/NFKBIA/VAV3/ARPC5/ARPC2/CDC42/ITGA5/PIK3R2/BCAR1/JUN/FYB1/PIK3CB/FN1/FCGR2A/CXCL8/TNF/WIPF1/RPS6KA1/PYCARD/MAP2K3/FOS/PKN1/AKT3/TLR4/ELMO1/LCP2/CD4	2.18345412596933
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/1247	18/9376	2.50628174284951	HEXB/NEU1/MAN2B1/HEXA/FUCA1/GLB1	2.50525101911203
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	17/1247	78/9376	1.63872267801698	ARPC1B/CTTN/ARPC5/HCLS1/ARPC2/CDC42/CTNNB1/ITGA5/CLTA/PIK3R2/BCAR1/SEPTIN3/PIK3CB/FN1/SEPTIN6/ARHGAP10/ELMO1	2.21852930491017
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	44/1247	250/9376	1.32331676022454	CTSL/ATP6V0C/ATP6V1C2/LGMN/HEXB/TFEB/SLC29A1/CLN3/CLTA/NEU1/SLC38A9/CLN8/AP2M1/ATP6V0A4/SLC29A2/MCOLN3/ATP6V1B2/CTSO/GAA/CTSH/MAN2B1/LITAF/HEXA/FUCA1/GM2A/CD68/PPT2/ATP6V1B1/PLA2G15/SLC15A3/ACP5/GLA/SNAP29/CLN6/LAPTM5/VPS11/BLOC1S4/AP1S3/TLR7/GUSB/GLB1/BORCS5/CD63/TLR3	2.0293562510857
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	22/1247	110/9376	1.5037690457097	LDHB/FLT1/LDHA/EPAS1/RPS6/HMOX1/EGLN2/CAMK2G/TFRC/PIK3R2/IFNGR2/PIK3CB/BCL2/SERPINE1/PLCG2/CDKN1B/AKT3/ANGPT1/TLR4/EIF4E/CYBB/IGF1	2.08152665391463
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	15/1247	68/9376	1.65856880041511	CEBPA/CSF1R/MYC/TCF7L2/CCNA2/PIK3R2/CD14/HRAS/PIK3CB/GRB2/ITGAM/AKT3/RUNX1/SPI1/DUSP6	2.1346551449391
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1247	24/9376	2.19299652499332	HS6ST2/GLCE/HS6ST1/EXTL2/XYLT1/NDST2/NDST1	2.29188516545472
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1247	51/9376	1.76914005377612	ATP6V0C/ATP6V1C2/GNAS/ATP6V0A4/TJP2/ATP6V1B2/PDIA4/PRKACA/PLCG2/KDELR2/ATP6V1B1/TJP1	2.15708073062726
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	28/1247	148/9376	1.4224842324281	FGFR1/MYC/TCF7L2/CTNNB1/E2F3/PIK3R2/JUN/AXIN2/HRAS/PIK3CB/GRB2/BAX/TP53/HEY1/LRP6/FZD10/NOTCH3/FOS/AKT3/FZD5/FRAT2/E2F2/NCOA3/BAK1/E2F1/FLT4/IGF1/WNT6	2.02902721962232
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	27/1247	142/9376	1.42963958570993	NFKBIA/PPARG/CSF1R/SQSTM1/SIRPA/IRF9/PIK3R2/JUN/IFNGR2/IFNAR2/PIK3CB/FCGR2A/SOCS1/GRB2/TNF/PLCG2/ITPR2/JUND/FOS/AKT3/TGFB1/FCGR3A/ACP5/TYROBP/LCP2/LILRB4/SPI1	2.02047662010434
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	34/1247	187/9376	1.367062768827	NFKBIA/YWHAE/HSP90AB1/HSP90AA1/GABARAP/IRF7/OAS3/GSDMD/NLRP7/IRF9/JUN/IFNAR2/GBP1/RNF31/NFKBIB/CXCL8/TNF/BCL2/ATG16L1/OAS1/TXN2/CASP4/PYCARD/ITPR2/OAS2/NAMPT/TRPM2/PKN1/TLR4/GPSM3/CARD16/CYBB/NAIP/CCL5	1.98576255436033
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	12/1247	52/9376	1.73511812966504	CYP11A1/HSD17B1/CYP2J2/CGA/GNAS/SCARB1/HSD3B1/ADCY2/PRKACA/CYP19A1/ALOX5/IGF1	2.08189094427219
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1247	52/9376	1.73511812966504	PLTP/ANGPTL4/MYLIP/SCARB1/LRP2/ABCA1/APOC2/LRPAP1/LIPG/CD36/APOE/APOC1	2.08189094427219
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1247	41/9376	1.83386468988988	ALDH7A1/GLDC/SHMT1/GCSH/ALAS1/SHMT2/PHGDH/CHDH/GATM/PIPOX	2.09570743593852
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1247	41/9376	1.83386468988988	MYC/TYMP/E2F3/HRAS/CXCL8/MDM2/HBEGF/TP53/E2F2/E2F1	2.09570743593852
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1247	170/9376	1.37108354167649	MGST3/GSTA3/GSTA4/HMOX1/MYC/SMARCB1/TCF7L2/CTNNB1/E2F3/PIK3R2/AXIN2/HRAS/PIK3CB/TXNRD1/SMARCE1/GRB2/BAX/TP53/GSTO1/GSTT1/LRP6/PLCG2/FZD10/AKT3/FZD5/FRAT2/TGFB1/E2F2/BAK1/E2F1/WNT6	1.91232178051911
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	23/1247	120/9376	1.44111200213847	BEX3/NFKBIA/YWHAE/CDC42/CAMK2G/PIK3R2/JUN/MAGED1/HRAS/PIK3CB/NFKBIB/GRB2/BAX/BCL2/TP53/PLCG2/SH2B2/RPS6KA1/IRS1/AKT3/NFKBIE/CALML4/CALM3	1.90470678036317
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	26/1247	139/9376	1.40640270462059	HSPA1A/HSPA1B/HSP90AB1/HSP90AA1/HSPA8/KRT23/GNAS/ATF6B/PIK3R2/JUN/HRAS/PIK3CB/GRB2/ADCY2/BCL2/HBEGF/HSPA6/PRKACA/GNAI1/ITPR2/FOS/AKT3/NCOA3/CALML4/CALM3/KCNJ5	1.89059637567839
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	17/1247	83/9376	1.5400044444015	RBBP7/CSNK2B/CBX3/CBX4/AURKB/RING1/PCGF2/EZH2/EPOP/HDAC1/RBBP4/SKP1/DCAF7/SUZ12/BCORL1/PHF1/EED	1.93534642684976
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	15/1247	71/9376	1.58848842856659	NFKBIA/ATP6V0C/ATP6V1C2/JAM3/CDC42/ATP6V0A4/JUN/ATP6V1B2/CXCL8/HBEGF/PLCG2/ATP6V1B1/TJP1/JAM2/CCL5	1.94943705334611
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	36/1247	204/9376	1.32685504033209	CTSL/CTTN/DDX5/RPS6/VAV3/HCLS1/FGFR1/CDC42/MYC/CTNNB1/ITGA5/CAMK2G/TWIST2/PIK3R2/HRAS/PIK3CB/FN1/GRB2/TNF/MDM2/HBEGF/TP53/PRKACA/PLCG2/FZD10/ITPR2/AKT3/FZD5/PPP1CC/TGFB1/TFAP4/TLR4/IGF1/SLC9A1/CD63/WNT6	1.8485812781429
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	25/1247	133/9376	1.41331677228356	FOXO4/SKP2/GABARAP/CCNB2/TNFSF10/PRMT1/CCNB1/PIK3R2/HRAS/PRKAG1/PIK3CB/DEPP1/GRB2/MDM2/FOXO6/CAT/PLK1/IRS1/CDKN1B/CDK2/AKT3/PLK4/FBXO32/TGFB1/IGF1	1.88019406006731
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	18/1247	90/9376	1.5037690457097	PPARG/ADIPOR2/ATF6B/PIK3R2/SESN2/HRAS/PRKAG1/PIK3CB/EHMT2/BAX/ADCY2/TP53/PRKACA/CAT/IRS1/AKT3/EIF4E/IGF1	1.88078302668795
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	12/1247	54/9376	1.670854495233	HLA-E/HLA-G/CGA/HLA-C/HLA-B/HLA-A/HLA-DRA/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-F/HLA-DMA	1.93629252107212
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	21/1247	109/9376	1.44858486054604	NFKBIA/HSP90AB1/HSP90AA1/IL6ST/EBI3/HLA-DRA/JUN/IFNGR2/NFKBIB/HLA-DRB1/RXRB/IL4R/IL2RB/HLA-DPB1/FOS/TGFB1/NFKBIE/HLA-DPA1/RUNX1/HLA-DMA/CD4	1.84496691672297
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1247	21/9376	2.148241493871	CHST11/DSEL/XYLT1/DSE/CHST14/CHST12	2.06310480944534
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/1247	32/9376	1.87971130713713	PMAIP1/BIRC5/BAX/BCL2/CASP7/CYCS/BIRC7/BAK1	1.95231122603152
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	26/1247	142/9376	1.37668997142438	ASS1/CTSL/HSP90AB1/MGST3/HSP90AA1/GSTA3/GSTA4/HMOX1/SQSTM1/CTNNB1/PIK3R2/JUN/PIK3CB/ICAM1/TNF/BCL2/TP53/GSTO1/GSTT1/TXN2/FOS/AKT3/MEF2C/ARHGEF2/CALML4/CALM3	1.77146916998607
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	15/1247	73/9376	1.54496819764696	MLLT1/SMARCB1/PSIP1/NELFE/CHMP4A/MX1/RAN/NELFCD/SUPT4H1/BST2/ELL/MX2/KAT2A/TRIM5/CD4	1.83071770613686
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/1247	44/9376	1.70882846103375	HEXB/DDOST/MGAT4B/MAN1A1/HEXA/FUT8/TUSC3/RPN2/B4GALT1/STT3B	1.84578207230496
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1247	44/9376	1.70882846103375	TAF9/CDK7/TAF15/GTF2H1/GTF2H4/TAF7/TAF4B/GTF2B/GTF2H2/TAF4	1.84578207230496
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/1247	44/9376	1.70882846103375	PARP1/FEN1/POLD4/POLD1/MUTYH/POLE2/APEX1/NEIL3/RFC4/HMGB1	1.84578207230496
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	20/1247	105/9376	1.432160995914	NFKBIA/IRF9/PIK3R2/IRF1/JUN/HRAS/PIK3CB/TNF/MDM2/KSR1/EGR3/PLCG2/PYCARD/ITPR2/LSP1/AKT3/EGR2/CALML4/CD209/CALM3	1.7441234843448
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	27/1247	150/9376	1.35339214113873	CCNE1/MYC/TCF7L2/CTNNB1/E2F3/PIK3R2/AXIN2/HRAS/PIK3CB/GRB2/BAX/BCL2/TP53/RXRB/ABCB1/LRP6/FZD10/CDKN1B/CDK2/AKT3/FZD5/FRAT2/TGFB1/E2F2/BAK1/E2F1/WNT6	1.70881912052528
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	42/1247	250/9376	1.26316599839615	ARPC1B/HSPA1A/HSPA1B/HLA-E/HLA-G/VPS28/ARPC5/HSPA8/HLA-C/ARPC2/HLA-B/CDC42/ASAP3/CHMP4A/CLTA/HLA-A/TFRC/AP2M1/ARRB1/RAB31/HRAS/FOLR2/FOLR1/RUFY1/GRK3/SNX5/MDM2/HSPA6/MVB12B/WIPF1/SNX4/IL2RB/RAB5C/DAB2/RAB8A/RAB11FIP4/ARF4/CYTH4/HLA-F/EHD3/IQSEC1/SNX3	1.65180909133056
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	19/1247	100/9376	1.42858059342422	CD24/CSF2RA/CSF1R/MME/CSF3R/ITGA5/TFRC/HLA-DRA/CD14/CR1/HLA-DRB1/TNF/IL4R/HLA-DPB1/ITGAM/CD36/HLA-DPA1/HLA-DMA/CD4	1.68753362456305
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1247	63/9376	1.5515077455735	DDB1/POLR2J3/CDK7/POLR2A/GTF2H1/POLD4/POLD1/ERCC5/GTF2H4/POLE2/GTF2H2/RAD23A/RFC4	1.72019385778934
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	22/1247	122/9376	1.35585733629563	DIO2/MYC/CTNNB1/PIK3R2/HRAS/PIK3CB/MDM2/TP53/PRKACA/TBC1D4/RXRB/HDAC1/PLCG2/MED17/MED16/NOTCH3/AKT3/KAT2A/NCOA3/SLC16A10/MED12L/SLC9A1	1.54949933616768
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	17/1247	90/9376	1.42022632094805	NFKBIA/CSNK2B/PIK3R2/JUN/IFNGR2/HRAS/PIK3CB/EML4/NFKBIB/TICAM2/MAP2K3/FOS/AKT3/NFKBIE/CD274/TLR4/CD4	1.56888268252603
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	12/1247	59/9376	1.52925665665394	MYC/TCF7L2/CTNNB1/PIK3R2/AXIN2/HRAS/PIK3CB/GRB2/BAX/TP53/AKT3/BAK1	1.59718267348196
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	21/1247	116/9376	1.3611702568924	ACTN4/VAV3/CLDN7/JAM3/CDC42/CTNNB1/CLDN19/PIK3R2/BCAR1/PIK3CB/ACTN1/ICAM1/GNAI1/CLDN23/PLCG2/ITGAM/CTNND1/ITGB2/VASP/JAM2/CYBB	1.53297750667132
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/1247	41/9376	1.65047822090089	SSBP1/RAD50/POLD4/RAD51/POLD1/SEM1/XRCC2/BABAM1/TOP3A	1.63481205162684
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1247	110/9376	1.367062768827	ID3/BMP7/E2F4/MYC/TFRC/ID2/LRRC32/TNF/PPP2CA/TGIF1/HDAC1/BAMBI/SKP1/ID1/GREM2/TGFB1/TGIF2/E2F5/SMAD7/SKIL	1.51666908374
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/1247	73/9376	1.44197031780383	FGFR1/E2F3/PIK3R2/HRAS/PIK3CB/BAX/MDM2/TP53/PDGFC/AKT3/E2F2/BAK1/E2F1/IGF1	1.48471578687344
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/1247	73/9376	1.44197031780383	E2F3/PIK3R2/HRAS/PIK3CB/EML4/GRB2/BAX/TP53/RXRB/PLCG2/AKT3/E2F2/BAK1/E2F1	1.48471578687344
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	18/1247	99/9376	1.367062768827	C1QA/KRT23/C1QC/HLA-DRA/C1QB/C2/HLA-DRB1/FCGR2A/ICAM1/HLA-DPB1/ITGAM/C3AR1/ITGB2/HLA-DPA1/FCGR3A/CFB/C1R/HLA-DMA	1.43798533966775
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/1247	93/9376	1.37441256865941	NFKBIA/HLA-DRA/MAF/JUN/IFNGR2/NFKBIB/HLA-DRB1/MAML1/IL4R/IL2RB/HLA-DPB1/NOTCH3/FOS/NFKBIE/HLA-DPA1/HLA-DMA/CD4	1.42117651243824
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/1247	88/9376	1.367062768827	SERPINE2/F13A1/C1QA/C1QC/C1QB/CR1/C2/VSIG4/F5/SERPINE1/ITGAM/C3AR1/ITGB2/A2M/CFB/C1R	1.35494252114202
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1247	50/9376	1.5037690457097	SAT1/ALDH7A1/CKMT1B/CNDP2/AOC1/CKMT1A/ARG2/SMS/SRM/GATM	1.3988433363813
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/1247	32/9376	1.64474739374499	AKR1B1/UGP2/GAA/GALT/GLA/B4GALT1/GLB1	1.43086438079247
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1247	32/9376	1.64474739374499	LDHB/LDHA/ACSS1/ACADS/ECHS1/BCKDHA/ACACA	1.43086438079247
Human Diseases	Immune disease	hsa05310	Asthma	7/1247	32/9376	1.64474739374499	PRG2/HLA-DRA/HLA-DRB1/TNF/HLA-DPB1/HLA-DPA1/HLA-DMA	1.43086438079247
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	14/1247	76/9376	1.38505043683788	PLIN2/SLC27A2/PPARG/OLR1/PLTP/ANGPTL4/CPT2/FABP7/DBI/RXRB/CD36/SORBS1/FABP4/FADS2	1.32002831015779
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1247	15/9376	2.0050253942796	HEXB/HEXA/B3GALT4/GLB1	1.52567435204815
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	35/1247	217/9376	1.21271697234653	HSP90AB1/MGST3/HSP90AA1/GSTA3/GSTA4/BIRC5/MYC/GNAS/ATF6B/ARRB1/ADRB1/PIK3R2/JUN/KPNA2/HRAS/PIK3CB/CDC6/GRB2/ADCY2/BCL2/PRKACA/GSTO1/GSTT1/EPHX2/RXRB/PTGES3/GNAI1/RPS6KA1/EPHX1/FOS/AKT3/CDC25A/KLF4/NR1I3/E2F1	1.24167599049721
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1247	83/9376	1.3588274509425	SLC27A2/ECH1/FAR2/IDH2/PRDX1/IDH1/DECR2/CAT/EPHX2/MPV17L2/PEX5/AMACR/PXMP2/HSD17B4/PIPOX	1.2860179804758
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	24/1247	144/9376	1.25314087142475	DUSP9/DLX5/ID3/TBX3/IL6ST/ISL1/FGFR1/MYC/CTNNB1/PIK3R2/ID2/AXIN2/HRAS/PIK3CB/PCGF2/GRB2/FZD10/ID1/AKT3/FZD5/KLF4/SKIL/IGF1/WNT6	1.19893578279136
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/1247	71/9376	1.37668997142438	LDHB/LDHA/FGFR1/MYC/IDH2/PIK3R2/IDH1/HRAS/PIK3CB/TP53/AKT3/SLC7A5/TIGAR	1.24782978266407
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	14/1247	78/9376	1.34953632307281	HSPD1/BTG3/BTG2/LSM2/BTG1/DCP2/PARN/EXOSC4/CNOT3/TOB2/EXOSC3/LSM7/LSM6/LSM8	1.21407396755523
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/1247	98/9376	1.30428947842168	ARPC1B/VAV3/ARPC5/ARPC2/CDC42/ASAP3/PIK3R2/MARCKSL1/PIK3CB/FCGR2A/LIMK2/PLCG2/CFL1/AKT3/FCGR3A/VASP/INPP5D	1.18596833241929
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	15/1247	85/9376	1.32685504033209	IMPDH2/TK1/PNP/TYMP/TYMS/NME2/GMPR2/AK6/ADSL/GMPR/RRM2/NME1/ENTPD6/UCKL1/CMPK2	1.18558780218548
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/1247	66/9376	1.367062768827	HLA-DRA/MAF/JUN/IFNGR2/HLA-DRB1/TNF/IL4R/HLA-DPB1/TGFB1/HLA-DPA1/TLR4/HLA-DMA	1.17202740494223
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	26/1247	160/9376	1.22181234963913	HLA-E/HLA-G/CLDN7/JAM3/HLA-C/HLA-B/HLA-A/CLDN19/HLA-DRA/SIGLEC1/CDH3/HLA-DRB1/VSIR/ICAM1/CLDN23/NECTIN1/HLA-DPB1/ITGAM/CNTNAP2/ITGB2/HLA-DPA1/CD274/JAM2/HLA-F/HLA-DMA/CD4	1.10834453381428
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/1247	93/9376	1.29356477050297	MMP14/CGA/CDC42/GNAS/CAMK2G/JUN/HRAS/GRB2/ADCY2/HBEGF/PRKACA/EGR1/ITPR2/MAP2K3/CALML4/CALM3	1.11429848151724
NA	NA	hsa04518	Integrin signaling	25/1247	154/9376	1.22059175788125	SPP1/FLT1/ACTN4/PGF/COL4A1/COL4A2/CDC42/CTNNB1/ITGA5/PIK3R2/PIK3CB/LAMB1/FN1/ACTN1/ICAM1/FRAS1/PDGFC/ITGAM/AKT3/TGFB1/ITGB2/ICAM4/COL2A1/FLT4/IGF1	1.08102910351993
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	27/1247	168/9376	1.20838584030244	SLC25A6/SLC25A5/HSP90AB1/HSP90AA1/GLUL/PARP1/SQSTM1/CHMP4A/CAMK2G/TNFSF10/IRF9/FTH1/IFNGR2/IFNAR2/RNF31/BAX/TICAM2/TNF/BCL2/PYCARD/AIFM1/TLR4/CYBB/EIF2AK2/MLKL/TLR3/HMGB1	1.06743267868637
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/1247	23/9376	1.63453157142359	SSBP1/POLD4/POLD1/EXO1/RFC4	1.19327897737886
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	23/1247	142/9376	1.21784112856772	SKP2/UBB/DDB1/CDC20/SIAH1/RPS27A/UBA52/UBE2S/UBE2C/UBE2I/RHOBTB1/HERC3/SOCS1/UBE2H/MDM2/UBE2N/PRPF19/SKP1/UBE2A/ANAPC4/BIRC7/HERC2/UBE2F	1.02444681963123
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/1247	149/9376	1.21108916432996	NDUFA7/NDUFA6/GNG10/NDUFA13/NDUFA3/NDUFS1/NDUFS3/NDUFA11/GNG12/NDUFC2/NDUFB9/GNG5/GABRE/ADCY2/PRKACA/GNAI1/ITPR2/MGLL/NDUFB8/NDUFA10/NAPEPLD/NDUFA9/KCNJ5/GABRA3	1.01725332403758
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	33/1247	212/9376	1.17038628557595	FLT1/VAV3/PGF/CSF1R/FGFR1/CDC42/GNAS/CTNNB1/PIK3R2/BCAR1/EFNA1/PFN1/HRAS/FYB1/PIK3CB/ENAH/ADCY2/PDGFC/GNAI1/MAP2K3/ITGAM/ID1/RAPGEF6/AKT3/CTNND1/ANGPT1/ITGB2/VASP/LCP2/CALML4/CALM3/FLT4/IGF1	0.982789094651588
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/1247	116/9376	1.23153499433122	ACSS1/TKT/GLDC/ADH5/SHMT1/RPIA/SDHD/IDH2/GCSH/IDH1/ACADS/ECHS1/MDH2/SHMT2/PHGDH/CAT/FBP1/ADPGK/SDHA	0.982744097952603
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/1247	130/9376	1.21458269076553	NFKBIA/COL4A1/COL4A2/GNG10/GNAS/ATF6B/ARRB1/PIK3R2/JUN/HRAS/PIK3CB/GNG12/GRB2/GNG5/ADCY2/PRKACA/GNAI1/FOS/AKT3/TGFB1/RLN2	0.964916474966776
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/1247	69/9376	1.30762525713887	VAV3/PIK3R2/HRAS/PIK3CB/GRB2/TNF/PLCG2/MAP2K3/AKT3/LCP2/ALOX5/INPP5D	1.00448158962429
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	25/1247	158/9376	1.1896907007197	SKP2/ATP6V1C2/RPS6/SLC38A9/PIK3R2/SESN2/HRAS/PIK3CB/ATP6V1B2/GRB2/TNF/SLC3A2/CASTOR1/LRP6/FZD10/RPS6KA1/IRS1/AKT3/FZD5/ATP6V1B1/PRR5/SLC7A5/EIF4E/IGF1/WNT6	0.941795336413064
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	30/1247	193/9376	1.16873241894537	NFKBIA/VAV3/CCL4/CCL3/CDC42/GNG10/ARRB1/PIK3R2/BCAR1/CCR1/HRAS/PIK3CB/GNG12/NFKBIB/CXCL8/GRB2/GNG5/GRK3/ADCY2/PRKACA/GNAI1/PLCG2/PREX1/AKT3/CCL4L2/DOCK2/CCL3L1/ELMO1/CCL5/CXCR6	0.927652241071965
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1247	50/9376	1.35339214113873	CR1/CXCL8/ICAM1/TNF/CD36/TGFB1/ITGB2/TLR4/HBA1	0.98128347895019
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1247	57/9376	1.31909565413132	CPT2/ACADS/ACADVL/ECHS1/ELOVL4/FADS1/PPT2/ACACA/HSD17B4/FADS2	0.946398328464396
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/1247	105/9376	1.2173368465269	UBB/CSNK2B/TFEB/SIAH1/RPS27A/UBA52/SQSTM1/GABARAP/PHB2/JUN/HRAS/TOMM40/VCP/ATG9A/TP53/RAB5C/E2F1	0.87713213738623
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/1247	71/9376	1.27079074285327	CGA/PIK3R2/IRF1/HRAS/PIK3CB/SOCS1/GRB2/ELF5/GALT/FOS/AKT3/SOCS7	0.897026147323053
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1247	19/9376	1.58291478495758	HEXB/HEXA/GUSB/GLB1	0.9961250456494
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1247	19/9376	1.58291478495758	GLDC/GCSH/BCKDHA/DHTKD1	0.9961250456494
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1247	26/9376	1.44593177472087	SLC19A1/SCARB1/SLC5A6/SLC19A3/SLC52A3	0.891763290613763
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	24/1247	157/9376	1.14937761455519	YWHAE/BMP7/BIRC5/MYC/DLG5/TCF7L2/CTNNB1/FRMD6/ID2/AXIN2/PPP2CA/RASSF6/SCRIB/SERPINE1/FZD10/ID1/FZD5/PPP1CC/TGFB1/ITGB2/TEAD4/LIMD1/SMAD7/WNT6	0.739254099713876
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/1247	46/9376	1.30762525713887	HMOX1/HMOX2/FTH1/ALAS1/FXN/HMBS/CPOX/GUSB	0.819144249618863
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	44/1247	300/9376	1.10276396685378	DUSP9/FLT1/HSPA1A/HSPA1B/PGF/HSPA8/CSF1R/FGFR1/STMN1/CDC42/MYC/GNA12/DAXX/ARRB1/CD14/JUN/RASA1/EFNA1/HRAS/GNG12/DUSP16/GRB2/TNF/TP53/HSPA6/PRKACA/DUSP5/PDGFC/MAP3K20/RPS6KA1/RASGRF2/MAP2K3/JUND/FOS/AKT3/ANGPT1/TGFB1/DDIT3/DUSP8/MEF2C/TAOK3/FLT4/DUSP6/IGF1	0.708523969826682
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/1247	122/9376	1.17096769952805	GNAS/CSH1/ATF6B/PIK3R2/BCAR1/HRAS/PIK3CB/SOCS1/GRB2/ADCY2/PRKACA/GNAI1/PLCG2/ITPR2/IRS1/MAP2K3/FOS/AKT3/IGF1	0.744439723183739
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	22/1247	144/9376	1.14871246547269	NFKBIA/ALDH7A1/ADH5/C1QA/TCF7L2/CTNNB1/ADIPOR2/C1QC/CD14/C1QB/ACADVL/PRKAG1/C2/CXCL8/TNF/MAP2K3/LY96/AKT3/C3AR1/ACACA/TLR4/TRA2B	0.704337846349445
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	21/1247	138/9376	1.14417209999651	RPS6/FLOT2/FLOT1/PIK3R2/HRAS/PRKAG1/PIK3CB/PPP1R3B/SOCS1/GRB2/PRKACA/SH2B2/IRS1/FBP1/AKT3/PPP1CC/SORBS1/ACACA/CALML4/EIF4E/CALM3	0.668239420537576
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/1247	75/9376	1.20301523656776	ASS1/TKT/GLUL/SHMT1/RPIA/IDH2/ARG2/IDH1/ACY1/SHMT2/MAT2A/PHGDH	0.691344872557815
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1247	75/9376	1.20301523656776	GPX3/CANX/CGA/GNAS/ATF6B/GSR/LRP2/PDIA4/ADCY2/PRKACA/HSPA5/ITPR2	0.691344872557815
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/1247	82/9376	1.19201204842842	IMPDH2/MGST3/GSTA3/GSTA4/TK1/TYMP/NME2/RRM2/GSTO1/GSTT1/NME1/UCKL1/GUSB	0.683965783662457
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/1247	89/9376	1.1827396988728	TUBB/TUBA1C/GNAS/CDK1/ADRB1/HRAS/GRB2/ADCY2/PRKACA/PDGFC/GNAI1/TUBB3/ITPR2/TJP1	0.678407262725041
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/1247	55/9376	1.2303564919443	HEXB/NEU1/SGPP1/HEXA/GM2A/UGCG/B4GALT5/GLA/GLB1	0.671043772061064
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	23/1247	154/9376	1.12294441725075	QPRT/GGH/UGP2/RDH13/SHMT1/NME2/ALAS1/AK6/ADSL/SHMT2/NAPRT/MAT2A/NME1/HMBS/DHFR/CPOX/GSS/GCLM/AFMID/GCH1/GUSB/CMPK2/COQ2	0.602499814317208
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1247	83/9376	1.1776504574835	NFKBIA/CCL4/GSDME/IRF7/GSDMD/NFKBIB/CASP7/PYCARD/CCL4L2/POLR3E/ZCCHC3/CCL5/MLKL	0.63668953410185
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/1247	140/9376	1.12782678428228	SPP1/RPS6/GNG10/TFAM/HRAS/PRKAG1/GNG12/GNG5/ADCY2/PRKACA/EGR1/GNAI1/SERPINE1/ITPR2/NOTCH3/AKT3/MEF2C/CALML4/AGTR1/CALM3/SLC9A1	0.596821173778588
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	20/1247	133/9376	1.13065341782684	HLA-E/HLA-G/VAV3/HLA-C/HLA-B/HLA-A/TNFSF10/PIK3R2/IFNGR2/HRAS/IFNAR2/PIK3CB/GRB2/ICAM1/TNF/PLCG2/ITGB2/FCGR3A/TYROBP/LCP2	0.59434747534754
NA	NA	hsa04517	IgSF CAM signaling	43/1247	299/9376	1.08130550109561	TUBB/ARPC1B/ACTN4/VAV3/ARPC5/NRP1/JAM3/ARPC2/FGFR1/CDC42/TUBA1C/CTNNB1/ITGA5/MTSS1/PIK3R2/MYH10/BCAR1/RASA1/EPB41L3/PIK3CB/ACTN1/TJP2/GRB2/ICAM1/TUBB3/PLCG2/NECTIN1/PAK6/ITGAM/RAPGEF6/AKT3/CNTNAP2/TJP1/GRIP1/MPDZ/SORBS1/ITGB2/LCP2/JAM2/CD209/INPP5D/DYNLL2/PMP22	0.559608961195004
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1247	28/9376	1.34265093366938	AKR1B1/GGH/DHFR/CBR1/GCH1	0.711167475662631
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1247	28/9376	1.34265093366938	ATP6V0C/ATP6V1C2/ATP6V0A4/ATP6V1B2/ATP6V1B1	0.711167475662631
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	23/1247	155/9376	1.11569961455881	CCNE1/CYP11A1/GNAS/TCF7L2/CTNNB1/CAMK2G/ATF6B/E2F3/SCARB1/AXIN2/HSD3B1/ADCY2/PRKACA/GNAI1/FZD10/ITPR2/CDKN1B/CDK2/FZD5/E2F2/AGTR1/E2F1/WNT6	0.568864789382053
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/1247	91/9376	1.15674541977669	NFKBIA/VAV3/PIK3R2/JUN/HRAS/PIK3CB/NFKBIB/GRB2/PLCG2/FOS/AKT3/NFKBIE/LILRB4/INPP5D	0.588470781824786
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/1247	77/9376	1.171768087566	CDC42/E2F3/PIK3R2/PIK3CB/RAD51/BAX/TP53/AKT3/TGFB1/E2F2/BAK1/E2F1	0.592747897534199
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/1247	70/9376	1.18153282162905	EPAS1/CDC42/EGLN2/PIK3R2/JUN/HRAS/PIK3CB/GRB2/PAK6/AKT3/TGFB1	0.597066847201691
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/1247	56/9376	1.20838584030244	DDOST/MGAT4B/MAN1A1/FUT8/TUSC3/RPN2/ST6GAL1/B4GALT1/STT3B	0.612568366936898
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1247	63/9376	1.193467496595	TCF7L2/CTNNB1/GLI3/AXIN2/BAX/TP53/FZD10/FZD5/BAK1/WNT6	0.603439574504124
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1247	22/9376	1.367062768827	ALDH7A1/CNDP2/AOC1/HNMT	0.675076977140557
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1247	29/9376	1.29635262561181	FRMD6/RASSF6/TEAD4/LIMD1/RASSF4	0.62599657936788
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1247	43/9376	1.22399806046139	ALDH7A1/ADH5/CPT2/ACADS/ACADVL/ECHS1/ECI1	0.576591393968266
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/1247	100/9376	1.12782678428228	IL10RB/CCL4/CSF1R/CCL3/IL6ST/TNFSF10/CCR1/TNFRSF14/CXCL8/TNF/IL2RB/IL10RA/CCL4L2/CCL3L1/CCL5	0.503317228791541
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	18/1247	122/9376	1.10933782060552	NFKBIA/VAV3/CDC42/PIK3R2/JUN/HRAS/PIK3CB/NFKBIB/GRB2/TNF/PPP2CA/PPP2R3B/PAK6/FOS/AKT3/NFKBIE/LCP2/CD4	0.47608651885576
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1247	79/9376	1.14210307269091	ATP6V0C/ATP6V1C2/CLTA/AP2M1/SLC6A4/ATP6V0A4/SLC1A3/ATP6V1B2/SLC6A2/ATP6V1B1/SLC6A11/NSF	0.496759180655507
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1247	16/9376	1.40978348035285	HEXB/HEXA/GLA	0.642505451318578
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1247	65/9376	1.15674541977669	AKR1B1/ALDH7A1/AGPAT1/ABHD16A/AGPAT5/DGAT1/MGLL/DGKZ/LIPG/GLA	0.4966537024844
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1247	23/9376	1.30762525713887	ASS1/GLUL/ARG2/ACY1	0.578509831167297
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1247	23/9376	1.30762525713887	ENPEP/MME/AGTR1/PRCP	0.578509831167297
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/1247	203/9376	1.0741207469355	SPP1/FLT1/ACTN4/VAV3/ZYX/PGF/COL4A1/COL4A2/CDC42/CTNNB1/ITGA5/PIK3R2/BCAR1/JUN/HRAS/PIK3CB/LAMB1/FN1/ACTN1/GRB2/BCL2/PDGFC/PAK6/AKT3/PPP1CC/VASP/COL2A1/FLT4/IGF1	0.418150299843872
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/1247	30/9376	1.25314087142475	SDHD/IDH2/IDH1/MDH2/SDHA	0.543889047040166
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/1247	80/9376	1.12782678428228	RPS6/PIK3R2/HRAS/PIK3CB/GRB2/BAX/BCL2/PDGFC/PLCG2/AKT3/EIF4E/IGF1	0.449696080907968
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/1247	59/9376	1.14694249249045	TK1/TYMP/TYMS/NME2/RRM2/NME1/ENTPD6/UCKL1/CMPK2	0.443440814684853
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1247	45/9376	1.1695981466631	TAP1/TAP2/ABCG2/ABCA1/ABCB1/ABCG1/ABCB6	0.446646121804225
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	15/1247	103/9376	1.09497746046823	DDX39B/RBM8A/MAGOH/PABPN1/FUS/EIF4A3/PNN/PPP2CA/ETF1/CPSF4/PPP2R3B/CPSF1/PAPOLA/PPP1CC/NXF1	0.379602740185201
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1247	17/9376	1.32685504033209	AMACR/CYP39A1/HSD17B4	0.528281286380894
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1247	17/9376	1.32685504033209	TXNRD1/SEPHS2/MARS2	0.528281286380894
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1247	17/9376	1.32685504033209	TFRC/MYH10/CD209	0.528281286380894
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	26/1247	184/9376	1.06244552142533	BMP7/NRP1/SEMA6A/SEMA4C/CDC42/SEMA7A/EFNB1/CAMK2G/PIK3R2/RASA1/EFNA1/HRAS/PIK3CB/SEMA3F/ENAH/SEMA6D/LIMK2/GNAI1/EPHA1/PLCG2/SEMA4B/PAK6/CFL1/SEMA3G/SEMA5B/EPHB4	0.335046822213482
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	19/1247	133/9376	1.0741207469355	GNG10/GNAS/CAMK2G/ATF6B/ARRB1/GNG12/GNG5/PPP2CA/PRKACA/GNAI1/COMT/ITPR2/PPP2R3B/FOS/AKT3/PPP1CC/CALML4/CALM3/KCNJ5	0.337178158403586
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	15/1247	104/9376	1.08444883104065	LPCAT1/LPCAT3/PHOSPHO1/PISD/AGPAT1/MBOAT7/AGPAT5/PLAAT3/CHKB/PTDSS1/CRLS1/LYPLA1/GPD1L/DGKZ/PLA2G15	0.339175054676565
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	17/1247	119/9376	1.0741207469355	NFKBIA/CEBPB/MMP14/ATF6B/PIK3R2/IRF1/JUN/PIK3CB/ICAM1/TNF/DAB2IP/CASP7/MAP2K3/FOS/AKT3/CCL5/MLKL	0.318697340374376
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	25/1247	178/9376	1.05601758827929	NOTUM/SERPINF1/SFRP1/CSNK2B/SIAH1/TBL1X/MYC/TCF7L2/CTNNB1/CAMK2G/JUN/AXIN2/TLE3/TP53/PRKACA/LRP6/FZD10/RNF43/RUVBL1/BAMBI/SKP1/ZNRF3/FZD5/FRAT2/WNT6	0.295520769496816
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/1247	61/9376	1.10933782060552	SLC40A1/HMOX1/MT2A/SLC39A4/HMOX2/FTH1/SLC34A2/TRPV6/ATP7B	0.335539925714831
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/1247	105/9376	1.0741207469355	NFKBIA/CSNK2B/CCL4/PARP1/CD14/UBE2I/CXCL8/ICAM1/TICAM2/TNF/BCL2/PLCG2/LY96/CCL4L2/TLR4	0.29913790608052
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1247	54/9376	1.113902996822	RAD51/UBE2T/FANCE/FANCI/FANCA/RMI2/TOP3A/FAAP24	0.328759101178181
Human Diseases	Substance dependence	hsa05032	Morphine addiction	13/1247	91/9376	1.0741207469355	GNG10/GNAS/ARRB1/GNG12/GNG5/GRK3/GABRE/ADCY2/PDE4B/PRKACA/GNAI1/KCNJ5/GABRA3	0.278272207001084
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1247	47/9376	1.11982801276254	LDHB/LDHA/ACSS1/ALDH7A1/ADH5/MDH2/ACACA	0.322544798450139
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1247	69/9376	1.08968771428239	GNAS/CAMK2G/ATF6B/JUN/PRKACA/HDAC1/FOS/PPP1CC/CALML4/CALM3	0.292855205226137
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	32/1247	232/9376	1.03708210048945	ARPC1B/ACTN4/VAV3/ARPC5/ARPC2/FGFR1/CDC42/ITGA5/GNA12/IQGAP2/PIK3R2/MYH10/BCAR1/PFN1/HRAS/PIK3CB/GNG12/PIP4K2B/FN1/ACTN1/ENAH/CYFIP2/LIMK2/PDGFC/PAK6/CFL1/ITGAM/AKT3/PPP1CC/IQGAP3/ITGB2/SLC9A1	0.223996129139652
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1247	62/9376	1.09144527511188	TLE3/DTX4/MAML1/HEY1/HDAC1/NRARP/DTX2/NOTCH3/KAT2A	0.282936711762369
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/1247	99/9376	1.063271042421	CYP2J2/GNAS/CAMK2G/PIK3R2/PIK3CB/ADCY2/PRKACA/PLCG2/ITPR2/MAP2K3/PPP1CC/CALML4/CALM3/IGF1	0.247867229132622
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1247	33/9376	1.1392189740225	IDH2/IDH1/ACY1/BCKDHA/DHTKD1	0.313770801850524
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1247	107/9376	1.0540437236283	LDHB/LDHA/GNAS/CAMK2G/PRMT1/PRKAG1/ADCY2/PRKACA/ITPR2/PPP4C/FBP1/AKT3/ACACA/CALML4/CALM3	0.220201876364662
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1247	70/9376	1.0741207469355	NFKBIA/ADIPOR2/PRKAG1/NFKBIB/TNF/RXRB/IRS1/CD36/AKT3/NFKBIE	0.243785340236965
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/1247	122/9376	1.04770794168299	PPARG/ADIPOR2/CCNA2/PIK3R2/PRKAG1/PIK3CB/EEF2/EEF2K/PPP2CA/IRS1/PPP2R3B/FBP1/CD36/AKT3/RAB8A/ACACA/IGF1	0.207733314527781
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1247	48/9376	1.09649826249666	CLDN7/CHMP4A/DPP4/CLDN19/SCARB1/CLDN23/CD63	0.262510178235832
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1247	63/9376	1.0741207469355	HPGD/CYP2J2/PLAAT3/HPGDS/EPHX2/PTGES3/LTC4S/CBR1/ALOX5	0.231188146742385
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	15/1247	108/9376	1.04428405952063	DDX39B/EEF1A1/RBM8A/MAGOH/KPNA2/RAN/UBE2I/EIF4A3/PNN/THOC3/THOC6/NUP210/IPO4/NUP37/NXF1	0.181286971610824
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/1247	86/9376	1.04914119468119	MYC/CAMK2G/PIK3R2/JUN/HRAS/PIK3CB/GRB2/HBEGF/PLCG2/CDKN1B/PAK6/AKT3	0.179302928276522
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/1247	94/9376	1.03984029756522	NFKBIA/S100A9/HSP90AB1/CEBPB/HSP90AA1/MAPK4/JUN/CXCL8/TNF/JUND/TRAF4/FOS/SRSF1	0.152042856888008
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/1247	109/9376	1.0347034718186	SLC27A2/NFKBIA/PIK3R2/PRKAG1/PIK3CB/PPP1R3B/SLC27A3/TNF/PPARGC1B/TBC1D4/RPS6KA1/IRS1/CD36/AKT3/PPP1CC	0.142730535584312
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1247	27/9376	1.113902996822	ELOVL4/FADS1/HSD17B4/FADS2	0.232131862521635
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1247	42/9376	1.0741207469355	ALDH7A1/AOC1/ECHS1/CAT/DHTKD1/AFMID	0.188551867090957
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1247	65/9376	1.04107087779903	CYP11A1/GNAS/ATF6B/SCARB1/HSD3B1/ADCY2/PRKACA/ITPR2/AGTR1	0.130134606499061
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1247	65/9376	1.04107087779903	SPP1/CGA/ARRB1/PIK3R2/HRAS/PIK3CB/ITPR2/AKT3/KCNJ5	0.130134606499061
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/1247	20/9376	1.12782678428228	FDFT1/DHCR24/LBR	0.224125905924924
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1247	20/9376	1.12782678428228	UGP2/NPL/NANS	0.224125905924924
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	14/1247	103/9376	1.02197896310368	MME/COL14A1/COL4A1/COL4A2/DPP4/KCNK5/COL21A1/SLC3A2/COL27A1/SLC16A10/SLC7A7/SLC7A8/COL2A1/PRCP	0.0878447852727945
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1247	89/9376	1.01377688474811	GLUL/GABARAP/GNG10/GNG12/GNG5/GABRE/ADCY2/PRKACA/GNAI1/SLC6A11/NSF/GABRA3	0.0511456390072773
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1247	13/9376	1.15674541977669	RAD50/FEN1	0.221492653924342
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1247	36/9376	1.04428405952063	AKR1B1/UGP2/DCXR/GUSB/CRYL1	0.104261877502334
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	48/1247	362/9376	0.996973952956709	CCNE1/SPP1/FLT1/YWHAE/HSP90AB1/RPS6/HSP90AA1/PGF/CSF1R/COL4A1/COL4A2/FGFR1/CSF3R/MYC/GNG10/CSH1/ITGA5/ATF6B/PIK3R2/EFNA1/HRAS/IFNAR2/PIK3CB/GNG12/LAMB1/FN1/GRB2/GNG5/PPP2CA/MDM2/BCL2/TP53/PDGFC/IL4R/LPAR6/IL2RB/IRS1/CDKN1B/PPP2R3B/PKN1/CDK2/AKT3/ANGPT1/TLR4/EIF4E/COL2A1/FLT4/IGF1	-0.0229970159746764
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/1247	98/9376	0.997397836440109	CYP11A1/GNAS/CAMK2G/ATF6B/SCARB1/HSD3B1/ADCY2/PRKACA/ITPR2/CALML4/AGTR1/CALM3/KCNJ5	-0.0101419332466341
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1247	37/9376	1.01606016602007	ASS1/GLUL/RIMKLB/ADSL/PPAT	0.0383354890464099
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1247	14/9376	1.0741207469355	FUT8/B4GALT1	0.108697558612828
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	31/1247	238/9376	0.979345386911782	FLT1/FOXO4/PGF/CSF1R/FGFR1/CDC42/GNG10/RGL2/PIK3R2/RASA1/EFNA1/HRAS/PIK3CB/GNG12/PLAAT3/GRB2/GNG5/PRKACA/PDGFC/KSR1/PLCG2/RGL1/RASGRF2/RAB5C/PAK6/AKT3/ANGPT1/CALML4/CALM3/FLT4/IGF1	-0.126409661627882
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1247	38/9376	0.989321740598489	HEXB/UGP2/HEXA/GALT/RENBP	-0.0258324521386372
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1247	38/9376	0.989321740598489	QPRT/PNP/NAPRT/NAMPT/SIRT2	-0.0258324521386372
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	12/1247	93/9376	0.970173577877228	ACTN4/CSNK2B/FGFR1/CDC42/TCF7L2/CTNNB1/SNAI1/ACTN1/NECTIN1/TJP1/CTNND1/SORBS1	-0.113213642166783
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1247	101/9376	0.967772158130007	GNAS/TCF7L2/CTNNB1/CAMK2G/HRAS/ADCY2/PRKACA/GNAI1/FZD10/FZD5/CALML4/CALM3/WNT6	-0.127536723345817
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	9/1247	70/9376	0.966708672241952	MGST3/GSTA3/GSTA4/GSTO1/HPGDS/GSTT1/SULT1A3/EPHX1/CBR1	-0.109496166727762
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	15/1247	117/9376	0.963954516480579	RBBP7/SMARCB1/INO80D/SMARCE1/MBD3/SMARCA1/TFPT/CECR2/HDAC1/MORF4L2/RBBP4/RUVBL1/INO80B/SRCAP/SS18	-0.153660431203616
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1247	31/9376	0.970173577877228	TKT/RPIA/FBP1/SHPK	-0.0651467353631081
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1247	31/9376	0.970173577877228	ALDH7A1/CNDP2/ACADS/ECHS1	-0.0651467353631081
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1247	23/9376	0.980718942854154	LARGE2/B3GALNT2/B4GALT1	-0.0362593150442612
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1247	47/9376	0.959852582367896	PIK3R2/PIK3CB/SOCS1/TNF/IRS1/MAFA	-0.108066055923847
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1247	63/9376	0.954773997276002	ALDH7A1/ECHS1/EHMT2/EZH2/SUV39H1/DHTKD1/SUV39H2/PIPOX	-0.141063281019353
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1247	32/9376	0.939855653568565	GABARAP/PPP2CA/ATG9A/ATG16L1	-0.133476154924671
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	18/1247	143/9376	0.946428070726387	ACTN4/C1QA/C1QC/HLA-DRA/C1QB/SNRPD1/C2/ACTN1/HLA-DRB1/FCGR2A/TNF/SNRPB/SNRPD3/HLA-DPB1/HLA-DPA1/FCGR3A/C1R/HLA-DMA	-0.252833252128691
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	12/1247	97/9376	0.930166420026621	GNG10/GNAS/CAMK2G/GNG12/GNG5/ADCY2/PRKACA/GNAI1/FOS/CALML4/CALM3/KCNJ5	-0.270769591259913
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/1247	98/9376	0.920674925944716	IMPA2/PIK3R2/PIK3CB/PIP4K2B/PLCG2/SYNJ2/ITPR2/ITPK1/DGKZ/CALML4/CALM3/INPP5D	-0.309169499663116
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/1247	169/9376	0.934294377511946	CTSL/UBB/RPS27A/UBA52/SQSTM1/GABARAP/PIK3R2/HRAS/PIK3CB/PPP2CA/BCL2/ATG9A/PRKACA/ATG16L1/SMCR8/IRS1/AKT3/RAB8A/SNAP29/VPS11/HMGB1	-0.337588091206509
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/1247	50/9376	0.902261427425822	HLA-DRA/HLA-DRB1/HLA-DPB1/TGFB1/HLA-DPA1/HLA-DMA	-0.271396093343127
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	19/1247	154/9376	0.927649735989752	GNAS/CAMK2G/JUN/HRAS/PRKAG1/EEF2/RGS2/EEF2K/ADCY2/PRKACA/GNAI1/ITPR2/TRPM2/FOS/PPP1CC/MEF2C/CALML4/CALM3/KCNJ5	-0.354558764088238
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	14/1247	115/9376	0.915337679997211	GNG10/CAMK2G/PIK3R2/HRAS/PIK3CB/GNG12/GNG5/ADCY2/BCL2/PRKACA/GNAI1/ITPR2/FOS/AKT3	-0.357775375759979
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1247	17/9376	0.884570026888061	GLUL/CA8	-0.186564339410312
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/1247	67/9376	0.897772564602808	CAMK2G/HRAS/PRKACA/RPS6KA1/ITPR2/PPP1CC/CALML4/CALM3	-0.328892261463966
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/1247	26/9376	0.867559064832521	RFX6/HHEX/MAFA	-0.264852093643346
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1247	43/9376	0.87428432890099	AGPAT1/SCARB1/ABCA1/DGAT1/CD36	-0.323603578947638
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/1247	76/9376	0.89038956653864	GNAS/CAMK2G/ADCY2/PRKACA/GNAI1/ITPR2/CALML4/CALM3/SLC9A1	-0.375766033265349
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/1247	60/9376	0.877198609997327	GNAS/GNA12/HRAS/PPP2CA/GNAI1/ITPR2/IGF1	-0.373735602372996
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	15/1247	125/9376	0.902261427425822	S1PR2/GNA12/PIK3R2/HRAS/PIK3CB/SGPP1/BAX/TNF/PPP2CA/BCL2/TP53/GNAI1/PPP2R3B/ORMDL1/AKT3	-0.430850857127536
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1247	18/9376	0.835427247616502	PRDX1/CD320	-0.273717754055009
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1247	44/9376	0.854414230516877	GNAS/PRKACA/RAB5C/NSF/DYNLL2	-0.379103856669033
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/1247	69/9376	0.871750171425915	GNAS/ADRB1/PRKACA/GNAI1/ITPR2/CALML4/AGTR1/CALM3	-0.418771179172013
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/1247	166/9376	0.905884967295002	PPIF/SLC25A6/SLC25A5/GNA12/ATF6B/ADRB1/RGS2/ADCY2/GNAI1/ITPR2/IRS1/AKT3/PPP1CC/VASP/MEF2C/CALML4/AGTR1/CALM3/ADRA2C/ADRA2B	-0.479163280509715
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/1247	87/9376	0.864235083741209	CYC1/COX4I2/COX4I1/UQCRC2/UQCRFS1/COX5A/MT-CO3/UQCRH/UQCR10/SLC9A1	-0.498268008606942
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	20/1247	168/9376	0.895100622446252	CSF2RA/IL10RB/IL6ST/CSF3R/MYC/CSH1/IRF9/PIK3R2/IFNGR2/HRAS/IFNAR2/PIK3CB/SOCS1/GRB2/BCL2/IL4R/IL2RB/IL10RA/AKT3/SOCS7	-0.537335086742068
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1247	28/9376	0.805590560201627	ECHS1/ELOVL4/PPT2	-0.40349421805399
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1247	28/9376	0.805590560201627	ST3GAL6/GCNT2/B4GALT1	-0.40349421805399
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	15/1247	128/9376	0.881114675220529	IMPDH2/PNP/NME2/GMPR2/AK6/ADSL/ATIC/GMPR/ADCY2/PDE4B/RRM2/PPAT/NME1/ENTPD6/GART	-0.530407462885548
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1247	79/9376	0.856577304518185	MGST3/ADH5/GSTA3/GSTA4/GSTO1/HPGDS/GSTT1/EPHX1/CBR1	-0.501372273982546
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1247	37/9376	0.812848132816056	MIF/ADH5/COMT/FAH	-0.446730024177798
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1247	37/9376	0.812848132816056	ICAM1/TNF/APOL1/HBA1	-0.446730024177798
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/1247	89/9376	0.844814070623429	SPP1/COL4A1/COL4A2/ITGA5/HMMR/LAMB1/FN1/FRAS1/CD36/COL2A1	-0.576115984710487
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/1247	38/9376	0.791457392478791	PIK3R2/PIK3CB/IRS1/IGF1	-0.50449860085773
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1247	56/9376	0.805590560201627	GLI3/ARRB1/LRP2/GRK3/BCL2/PRKACA	-0.57148351769759
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/1247	99/9376	0.835427247616502	PIK3R2/JUN/HRAS/PIK3CB/GRB2/CHKB/PDGFC/LYPLA1/DGKZ/FOS/AKT3	-0.644721353768722
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/1247	48/9376	0.78321304464047	ALDH7A1/ACADS/ECHS1/BCKDHA/HIBADH	-0.589738932269418
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	17/1247	149/9376	0.857854824733723	GNAS/GNA12/PIK3R2/AGPAT1/AGPAT5/HRAS/PIK3CB/CXCL8/GRB2/ADCY2/PDGFC/PLCG2/LPAR6/DGKZ/AKT3/CYTH4/AGTR1	-0.685007458788826
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1247	49/9376	0.76722910495393	GNAS/ATF6B/JUN/PRKACA/GNAI1	-0.639817377411413
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1247	31/9376	0.727630183407921	BAG6/HSPA5/SEC11A	-0.594908912955913
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/1247	67/9376	0.785550994027457	LDHB/LDHA/ACSS1/ALDH7A1/ADH5/FBP1/ADPGK	-0.689938256486345
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1247	93/9376	0.808477981564357	GNAS/ADRB1/ADCY2/PRKACA/ITPR2/TRPV6/CALML4/CALM3/PRH1/SLC9A1	-0.726969704008794
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1247	12/9376	0.626570435712376	COQ2	-0.506954428971293
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1247	12/9376	0.626570435712376	CD209	-0.506954428971293
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/1247	60/9376	0.751884522854852	CDC42/PIK3R2/HRAS/PIK3CB/PLCG2/AKT3	-0.755118385116706
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/1247	154/9376	0.830002395359252	GNAS/CAMK2G/ATF6B/ADRB1/PPP2CA/ADCY2/BCL2/PRKACA/GNAI1/CREM/PPP2R3B/AKT3/PPP1CC/CALML4/AGTR1/CALM3/SLC9A1	-0.833088053290961
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1247	78/9376	0.771163613184463	ISYNA1/IMPA2/PIK3CB/PIP4K2B/PLCG2/SYNJ2/ITPK1/INPP5D	-0.794836707154663
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/1247	33/9376	0.683531384413501	BNIP1/STX6/SNAP29	-0.713254870396119
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/1247	34/9376	0.663427520166046	POLR2J3/POLR2A/POLR3E	-0.770013665674847
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/1247	115/9376	0.784575154283323	CYP2J2/GNG10/GNAS/SLC6A4/HRAS/GNG12/GNG5/PRKACA/GNAI1/ITPR2/KCNJ5/ALOX5	-0.910366088736763
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1247	35/9376	0.644472448161301	AKR1B1/FBP1/TIGAR	-0.825298207030973
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1247	73/9376	0.720985158901913	MGST3/ADH5/GSTA3/GSTA4/GSTO1/HPGDS/GSTT1	-0.937297647970534
Organismal Systems	Immune system	hsa04611	Platelet activation	13/1247	126/9376	0.775753872786752	GNAS/PIK3R2/PIK3CB/FCGR2A/ADCY2/PRKACA/GNAI1/PLCG2/ITPR2/AKT3/PPP1CC/VASP/LCP2	-0.992520900170823
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1247	36/9376	0.626570435712376	UGP2/GAA/AGL	-0.879198246704792
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/1247	36/9376	0.626570435712376	C1GALT1C1/GALNT4/B4GALT5	-0.879198246704792
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1247	26/9376	0.578372709888347	PLAAT3/FADS2	-0.843159785771901
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/1247	37/9376	0.609636099612042	UGP2/GALT/NANS	-0.931795537402005
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1247	66/9376	0.683531384413501	CYP11A1/HSD17B1/HSD3B1/CYP19A1/STS/COMT	-1.01048082718058
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1247	27/9376	0.556951498411001	ACADS/ECHS1	-0.902923335915315
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	36/1247	323/9376	0.838013709683426	CCNE1/DNMT1/SOX4/HMOX1/STMN1/MYC/ITGA5/E2F3/PIK3R2/EFNA1/HRAS/UBE2I/TP63/PIK3CB/SOCS1/DNMT3A/GRB2/EZH2/HNRNPK/KIF23/MDM2/BCL2/TP53/CCNG1/CDCA5/ABCB1/HDAC1/PLCG2/IRS1/CDKN1B/NOTCH3/CDC25A/E2F2/ZEB2/BAK1/E2F1	-1.16033545801249
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1247	38/9376	0.593593044359093	TAP1/TAP2/CD4	-0.983164749576823
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1247	48/9376	0.626570435712376	PIK3R2/PIK3CB/SLC37A4/AKT3	-1.01586348752204
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1247	16/9376	0.469927826784282	MIF	-0.831107834288806
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/1247	49/9376	0.613783283963144	C1GALT1C1/GALNT4/ST6GAL1/B4GALT1	-1.06159391756535
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	24/1247	226/9376	0.798461440199842	NFKBIA/VAV3/CGA/GNAS/CAMK2G/GLI3/ADRB1/PIK3R2/JUN/PIK3CB/ADCY2/PDE4B/PRKACA/GNAI1/HCAR1/FOS/HCAR2/AKT3/PPP1CC/HCAR3/CALML4/CALM3/SLC9A1/NPY1R	-1.20116349924543
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/1247	105/9376	0.716080497957001	GNAS/ITGA5/ADRB1/SSPN/TNF/ADCY2/PRKACA/TGFB1/SNTB1/IGF1	-1.14584767218375
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1247	17/9376	0.44228501344403	CDO1	-0.901409965201518
NA	NA	hsa04081	Hormone signaling	23/1247	219/9376	0.789650412130666	SLC40A1/DIO2/CGA/GNG10/GNAS/CSH1/ADIPOR2/GNA12/ADRB1/PIK3R2/PIK3CB/GNG12/GNG5/ADCY2/PRKACA/GNAI1/IRS1/GUCA2A/SLC16A10/AGTR1/ADRA2C/ADRA2B/IGF1	-1.23363709207781
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1247	29/9376	0.518541050244725	CALML4/CALM3	-1.01700349382982
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/1247	194/9376	0.775138683355517	TUBB/TNNI2/TNNT3/TUBA1C/DYNLRB1/MYH10/KIF26B/MYO7A/KIF23/KIFC1/KIF20A/KIF18A/MYO19/TUBB3/KIF2C/KIF14/KIF4A/KIF11/KIF20B/DYNLL2	-1.23950211798375
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/1247	116/9376	0.712993944086497	GLUL/GNG10/GNAS/GNG12/SLC1A3/GNG5/GRK3/ADCY2/PRKACA/GNAI1/ITPR2	-1.21818953692226
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1247	30/9376	0.501256348569901	B3GALT4/PIGW	-1.07158203164471
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1247	30/9376	0.501256348569901	CYP2J2/PLAAT3	-1.07158203164471
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1247	18/9376	0.417713623808251	ACACA	-0.968459947346768
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1247	90/9376	0.668341798093201	GNAS/ABCG2/SCARB1/ADCY2/PRKACA/ABCB1/EPHX1/SLC9A1	-1.23822041493117
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1247	72/9376	0.626570435712376	NFKBIA/IRF7/ISG15/NFKBIB/CXCL8/TNF	-1.2457772579613
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1247	31/9376	0.485086788938614	ALDH7A1/GUSB	-1.12467109054872
NA	NA	hsa04082	Neuroactive ligand signaling	20/1247	199/9376	0.755662837040052	P2RX4/GNG10/GNAS/SLC6A4/ADRB1/GNG12/P2RY6/SLC1A3/GNG5/GABRE/ADCY2/PRKACA/GNAI1/OGFR/SLC6A2/SLC6A11/OGFRL1/ADRA2C/GABRA3/ADRA2B	-1.36447631803203
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/1247	53/9376	0.567460017248945	GNAS/CLTA/AP2M1/PRKACA	-1.23676348519013
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	19/1247	195/9376	0.73260543252524	PPIF/SLC25A6/SLC25A5/GSDMD/PIK3R2/CR1/PIK3CB/FCGR2A/HDAC1/PLCG2/CASP4/ITGAM/AKT3/ITGB2/FCGR3A/TLR4/CYBB/TLR7/HMGB1	-1.47783243747873
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/1247	34/9376	0.44228501344403	PRKAG1/SKP1	-1.27594555981412
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1247	23/9376	0.326906314284718	SLC25A10	-1.26579760746738
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1247	51/9376	0.44228501344403	LPCAT1/PLAAT3/ENPP2	-1.56413158406661
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/1247	134/9376	0.61721863816443	ADM/GNAS/GNA12/MYH10/ADCY2/PRKACA/ITPR2/PPP1CC/CALML4/AGTR1/CALM3	-1.74791578126432
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1247	41/9376	0.366772937977976	GABRE/GABRA3	-1.59145563855486
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/1247	99/9376	0.531635521210501	ITGA5/PRKAG1/SSPN/TNF/TGFB1/SNTB1/IGF1	-1.83483946430385
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/1247	298/9376	0.706468679192478	CSF2RA/GDF15/IL10RB/CCL4/BMP7/CSF1R/CCL3/IL6ST/CSF3R/EBI3/CSH1/TNFSF10/CCR1/IFNGR2/IFNAR2/INHA/TNFRSF14/CXCL8/TNF/IL4R/IL2RB/IL10RA/CCL4L2/TGFB1/CCL3L1/CD4/CCL5/CXCR6	-2.01682304343924
NA	NA	hsa04519	Cadherin signaling	39/1247	404/9376	0.725829118597505	KRT7/ARPC1B/ACTN4/NFKBIA/YWHAE/VAV3/ARPC5/ARPC2/FGFR1/CDC42/KRT23/TCF7L2/CTNNB1/AXIN2/MYO7A/HRAS/ACTN1/CDH3/ENAH/CYFIP2/GABRE/LRP6/FZD10/MAP2K3/FZD5/PPP1CC/TJP1/MPDZ/CTNND1/TMC5/PCDH12/TEAD4/VASP/LIMD1/TAOK3/TMC4/FLT4/GABRA3/WNT6	-2.20631583242618
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/1247	86/9376	0.437142164450495	GNAS/CAMK2G/ATF6B/ADCY2/PRKACA	-2.05371600695017
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/1247	86/9376	0.437142164450495	TCF7L2/CTNNB1/ITGA5/SSPN/SNTB1	-2.05371600695017
Human Diseases	Substance dependence	hsa05034	Alcoholism	15/1247	191/9376	0.59048522737292	SLC29A1/GNG10/GNAS/ATF6B/SLC29A2/HRAS/GNG12/GRB2/GNG5/PRKACA/GNAI1/HDAC1/PPP1CC/CALML4/CALM3	-2.23947892275656
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	14/1247	183/9376	0.575212203276936	CSNK2B/FBL/NOP56/RAN/AK6/NOB1/EMG1/RPP25L/UTP4/NHP2/NXF1/TCOF1/UTP6/LSG1	-2.27284201932062
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/1247	233/9376	0.613124718207819	FBLN1/CSRP2/TNNI2/ZYX/TNNT3/COL4A1/COL4A2/ITGA5/LMNB2/LMNB1/MYH10/BGN/SSPN/FN1/LBR/COL27A1/MYOZ1/FHL3/SNTB1	-2.34209704687456
NA	NA	hsa04382	Cornified envelope formation	17/1247	217/9376	0.589033957996888	KRT7/S100A9/CLDN7/COL4A1/COL4A2/KRT23/BLMH/CLDN19/ELOVL4/PPP2CA/EPHX2/PADI1/CLDN23/PPP2R3B/UGCG/TJP1/PCSK6	-2.3988996347392
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1247	68/9376	0.331713760083023	ADH5/RDH13/DGAT1	-2.1661528141503
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	20/1247	254/9376	0.592035057366025	FLT1/PPIF/SLC25A6/SLC25A5/TFEB/FGFR1/P2RX4/GNAS/CAMK2G/ADRB1/MCOLN3/ADCY2/PRKACA/PDGFC/PLCG2/ITPR2/CALML4/AGTR1/CALM3/FLT4	-2.58163578462503
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1247	86/9376	0.349713731560396	KCNK5/PRKACA/GABRA3/SCN9A	-2.37271871198256
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/1247	102/9376	0.368570844536692	GNAS/ADCY2/ITPR2/RAB8A/SLC9A1	-2.51125881546031
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	23/1247	370/9376	0.467387676369232	CGA/S1PR2/ADM/P2RX4/CSH1/ADRB1/P2RY6/GABRE/LPAR6/OGFR/CHRNB1/CHRNA5/C3AR1/NMU/VGF/AGTR1/OGFRL1/TMEM97/ADRA2C/RLN2/GABRA3/ADRA2B/NPY1R	-4.09398648690989
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1247	449/9376	0.117220304231269	CAMK2G/ARRB1/RGS2/GRK3/PRKACA/CALML4/CALM3	-7.50797887454712