category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	66/1692	174/9376	2.10189940490748	MAN1A1/RRBP1/SEC24D/GANAB/P4HB/TXNDC5/RPN2/SEC61A1/XBP1/CANX/WFS1/CKAP4/ATF6B/MOGS/SEC23A/PDIA4/EDEM2/PRKCSH/SEC24A/UGGT1/RPN1/HYOU1/BCAP29/ATF4/MAPK9/UGGT2/RNF5/DDOST/SYVN1/TRAM1/MAN1A2/EDEM3/STT3B/DNAJC10/SKP1/SEL1L/MAP2K7/EDEM1/SIL1/LMAN2/PDIA3/OS9/LMAN1/SEC31A/DNAJC5/BCAP31/SSR3/STT3A/TUSC3/SEC24C/ERP29/RNF185/MAN1B1/CUL1/MBTPS1/UBQLN2/SSR2/UBQLN4/BAK1/UBXN6/PREB/DERL3/PDIA6/UBE2D4/MAN1C1/TRAF2	6.88442380523004
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	80/1692	250/9376	1.77323877068558	GAA/LGMN/CTSB/GM2A/AP2A2/NAGLU/CLN3/PSAP/IGF2R/HEXB/CTSV/SLC15A3/CLTB/GLB1/SLC36A1/HEXA/CD68/SNAP29/AP3S1/ENTPD4/AGA/MAN2B1/CD63/OSTM1/SCARB2/ARSA/PLEKHM1/CLN5/LAMP2/SLC38A9/HGSNAT/AP3D1/AP3B1/GGA1/HYAL4/AP5B1/FUCA2/OSBPL2/CTSA/SLC36A4/MITF/CTSL/NAGA/DMXL1/ARSB/SLC17A5/CLCN7/GUSB/CD164/CTSO/SLC29A2/VPS39/VAMP7/AP1B1/SLC29A1/LAMP1/GGA3/CTSZ/SLC11A2/PIKFYVE/ATP6V0A1/DEPTOR/AP4E1/CLN6/SLC29A3/LAPTM4A/ROGDI/PPT2/VPS18/TPCN1/MTOR/BORCS6/PLA2G15/GALNS/AP1G2/ATP6V1C2/ATP6V1E2/ZFYVE26/TLR7/RPTOR	5.81481006207284
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	28/1692	56/9376	2.77068557919622	MAN1A1/MGAT5/MGAT4A/MGAT4B/GANAB/MAN2A1/RPN2/MOGS/DHRSX/RPN1/MGAT1/DDOST/MAN1A2/STT3B/MGAT5B/STT3A/TUSC3/B4GALT2/FUT8/MAN1B1/B4GALT3/MGAT3/DPAGT1/ALG9/ALG1/DPM2/DOLK/MAN1C1	6.23619443129229
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	53/1692	144/9376	2.03953244024166	FGFR1/PIK3CB/DLX5/DUSP9/MAPK3/AXIN2/PIK3R2/JARID2/AKT3/ID1/BMPR2/IL6ST/SMAD3/LIFR/ID3/KAT6A/JAK1/INHBA/GRB2/TBX3/PCGF2/RAF1/FZD8/PCGF3/AKT1/HRAS/SMAD4/RIF1/KLF4/BMI1/ZFHX3/WNT7A/TCF7/DVL3/NRAS/BMPR1B/ESX1/FZD5/ACVR1/PIK3R3/AKT2/TCF3/AXIN1/MAPK14/FZD9/FZD10/OTX1/ISL1/JAK2/SETDB1/ACVR2B/FZD2/FGFR3	5.89879813568602
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	38/1692	98/9376	2.1486949389685	DGKZ/IMPA2/PIK3CB/INPPL1/ITPR2/INPP5B/PLCG2/PIK3R2/IPMK/SYNJ2/PI4KA/MTMR4/PIP4K2B/MTMR1/CALM3/PIK3C2A/IPPK/PIKFYVE/PIK3C2B/PIK3R3/INPP4A/PIP4P2/PLCD3/PLCB1/SYNJ1/DGKH/PIK3C3/MTMR3/INPP5A/CDS2/PLCG1/PIP4K2C/PI4K2A/DGKQ/PLCB3/OCRL/CALML4/INPP5E	5.36392504988897
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	21/1692	44/9376	2.64474532559639	MAN1A1/MGAT4A/MGAT4B/MAN2A1/RPN2/HEXB/HEXA/RPN1/MGAT1/DDOST/MAN1A2/STT3B/STT3A/TUSC3/B4GALT2/FUT8/MAN1B1/B4GALT3/ALG9/ALG1/MAN1C1	5.13132796836239
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	68/1692	227/9376	1.65997021484884	HLA-G/PIK3CB/IL10RB/ITPR2/CCL3/MAPK3/IL10RA/PXN/IL1R1/TAPBP/RAC3/PIK3R2/IRF3/TAP1/CREB3L2/TAP2/PTK2B/CREB5/GNG12/CCR1/AKT3/ATF6B/CCL4/CCL4L2/BCAR1/ATF4/PTGER3/CRKL/GNAI1/TAPBPL/JAK1/ADCY7/GRB2/RAF1/AKT1/RB1/NFATC4/PTK2/TSC1/HRAS/GNA12/PDIA3/GNAS/SP1/ROCK2/CALM3/ADCY5/TBK1/SOS1/NRAS/PIK3R3/EGFR/AKT2/BAK1/EIF4EBP1/PLCB1/MAPK14/E2F3/ADCY9/RIPK1/TP53/GNA11/MTOR/FADD/PLCB3/CALML4/TRAF2/TRADD	4.72326801919006
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	19/1692	38/9376	2.77068557919622	GFPT1/UGDH/HEXB/GNE/HEXA/PGM3/UGP2/GALE/GALK1/GMPPA/PMM2/UXS1/GALT/HK1/GNPDA1/PGM1/RENBP/GFPT2/GALK2	5.13213950696877
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	73/1692	253/9376	1.59889365439782	ITGA5/PIK3CB/CTTN/ITPR2/TECPR1/MAPK3/PLCG2/PXN/ACTN4/IL1R1/ARPC1B/PIK3R2/IRF3/SEPTIN3/ARHGEF2/AKT3/FOXO1/WIPI1/BCAR1/ITGB1/CYTH3/TLN1/CD14/MAPK9/CRKL/RNF31/ELMO1/ACTN1/SKP1/AKT1/PTK2/FNBP1L/ATM/CBX3/ATG16L1/FOXO4/PRKCE/RBCK1/ROCK2/SEPTIN9/MAP3K7/TBK1/HK1/ACTR3B/ARPC2/ILK/PIK3R3/EGFR/CUL1/AKT2/TLN2/WIPI2/RPS6KA5/PLCD3/GSK3A/PLCB1/MAPK14/RIPK1/PIK3C3/TP53/CYTH2/PLCG1/MTOR/DOCK1/PLCB3/TAB1/ELMO2/UBE2D4/SEPTIN8/TRAF2/TRADD/MYL2/RPTOR	4.53140911732885
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	30/1692	78/9376	2.13129659938171	IMPA2/PIK3CB/INPPL1/INPP5B/PLCG2/IPMK/SYNJ2/PI4KA/ISYNA1/MTMR4/PIP4K2B/MTMR1/PIK3C2A/IPPK/PIKFYVE/PIK3C2B/INPP4A/PLCD3/PLCB1/SYNJ1/PIK3C3/MTMR3/MINPP1/INPP5A/PLCG1/PIP4K2C/PI4K2A/PLCB3/OCRL/INPP5E	4.70783411365596
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	45/1692	138/9376	1.80696885599753	PTPRF/PIK3CB/FASN/INPPL1/PRKAG2/MAPK3/PIK3R2/CBL/RAPGEF1/AKT3/CBLB/FOXO1/SREBF1/INSR/FLOT2/SH2B2/PPP1R3B/MAPK9/PHKA2/CRKL/PRKAG1/GRB2/RAF1/AKT1/TSC1/HRAS/GYS1/CALM3/PPP1R3D/PRKCI/HK1/SOS1/MKNK1/NRAS/PHKB/PIK3R3/AKT2/ACACA/EIF4EBP1/INPP5A/MTOR/PYGB/CALML4/PRKAB2/RPTOR	4.48125314359138
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	41/1692	122/9376	1.86226407782041	PIK3CB/ITPR2/MAPK3/PLCG2/PIK3R2/CREB3L2/CREB5/AKT3/ATF6B/BCAR1/IGFBP3/ATF4/MAPK9/FOS/EP300/CRKL/GNAI1/ADCY7/GRB2/RAF1/AKT1/PTK2/HRAS/GNAS/ADCY5/SOS1/NRAS/PIK3R3/AKT2/CSH1/PLCB1/SST/MAPK14/ADCY9/GNA11/PLCG1/SSTR2/MTOR/CACNA1C/PLCB3/JAK2	4.49829155720891
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	25/1692	62/9376	2.2344238541905	TLE3/NCSTN/TLE6/DTX4/NCOR2/HEY1/ITCH/CTBP2/EP300/TLE1/SPEN/MAML2/DTX3L/MAML1/NOTCH3/HDAC1/DVL3/DTX2/TLE2/MAML3/KAT2A/APH1B/ATXN1L/PSEN2/PTCRA	4.57598058240108
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	24/1692	59/9376	2.25411708137997	TCF7L2/PIK3CB/MAPK3/AXIN2/PIK3R2/ERBB2/AKT3/TCF7L1/GRB2/RAF1/AKT1/HRAS/TCF7/SOS1/NRAS/ILK/PIK3R3/EGFR/AKT2/AXIN1/BAK1/TP53/CTNNA3/CDH1	4.53438279405084
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	54/1692	178/9376	1.68109012670332	NOTUM/SFRP1/TCF7L2/BAMBI/TLE3/AXIN2/RAC3/ANKRD6/CSNK2B/CTNND2/TLE6/CSNK1E/CAMK2G/SMAD3/CTBP2/MAPK9/EP300/TLE1/GPC4/TCF7L1/SKP1/FZD8/NFATC4/APCDD1/SMAD4/CSNK1A1/PPARD/FRAT2/ROCK2/SIAH1/MAP3K7/WNT7A/TCF7/FRAT1/DVL3/TBL1Y/FZD5/TLE2/DAAM2/CUL1/AXIN1/CSNK2A2/RYK/PLCB1/TP53/CCAR2/FZD9/FRZB/FZD10/LRP6/LZTS2/PLCB3/CELSR2/FZD2	4.30486981803777
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	15/1692	29/9376	2.86622646123747	LIMD1/TEAD1/CSNK1E/TEAD3/PAK1/RASSF6/WWTR1/RASSF4/SAV1/LATS1/MOB1B/FRMD6/AJUBA/STK3/WTIP	4.72301538269966
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	89/1692	333/9376	1.4810271264172	ITGA5/SPP1/COL4A1/COL4A2/FN1/CCNE1/TCF7L2/HLA-G/PIK3CB/IFNAR2/HES2/MAPK3/PXN/AXIN2/PIK3R2/IRF3/CREB3L2/CREB5/AKT3/STAT2/FOXO1/PARD6G/LAMA5/ITGB1/HEY1/LAMB1/PARD3/EP300/PPP2R3B/LAMA4/MAML2/JAK1/ISG15/TCF7L1/GRB2/RAF1/FZD8/AKT1/RB1/MAML1/PTK2/TSC1/HRAS/IFNAR1/SCRIB/PPP2R5E/ATM/CHD4/LAMC1/GNAS/NOTCH3/CSNK1A1/BCAP31/DLG1/PRKCI/TYK2/LLGL2/WNT7A/TBK1/TCF7/SOS1/HDAC1/DVL3/NRAS/RBL2/TRAF3/FZD5/MAML3/PIK3R3/EGFR/ATP6V0A1/AKT2/ITGA3/AXIN1/BAK1/EIF4EBP1/TP53/FZD9/FZD10/MTOR/FADD/TBP/ATP6V1C2/NFX1/ATR/ATP6V1E2/TRADD/FZD2/TBPL1	4.19399162505005
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	32/1692	90/9376	1.97026530076175	PPARG/PIK3CB/PRKAG2/PIK3R2/CREB3L2/SESN2/CREB5/AKT3/ATF6B/FOXO1/INSR/EHMT2/ATF4/PRKAG1/ADCY7/AKT1/TSC1/HRAS/ATG13/STK11/ADCY5/NRAS/PIK3R3/CAMKK2/AKT2/EIF4EBP1/ADCY9/TP53/MTOR/ULK1/PRKAB2/RPTOR	4.33999825263114
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	40/1692	122/9376	1.81684300275162	DIO2/PIK3CB/MAPK3/PLCG2/MED13L/PIK3R2/TBC1D4/AKT3/FOXO1/RXRB/EP300/SLC9A1/RXRA/SLC16A2/NCOA3/ATP1A1/PFKL/RAF1/AKT1/HRAS/NCOA1/THRB/RCAN1/NOTCH3/MED16/HDAC1/NRAS/PIK3R3/NCOR1/NCOA2/AKT2/PLCD3/PLCB1/KAT2A/TP53/PLCG1/MTOR/MED12/MED24/PLCB3	4.26133719049361
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	13/1692	24/9376	3.00157604412924	EXTL3/HS6ST1/NDST1/B4GALT7/EXT2/XYLT1/HS3ST1/GLCE/NDST2/B3GALT6/XYLT2/EXTL1/B3GAT3	4.60699356633176
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	61/1692	212/9376	1.59445113519782	FGFR1/FLT1/PGF/CSF1R/PIK3CB/EFNA1/VAV3/APBB1IP/MAPK3/RAC3/PIK3R2/VASP/RAPGEF1/EVL/PRKD3/AKT3/ID1/VAV2/PARD6G/BCAR1/ITGB1/PDGFB/INSR/TLN1/PARD3/FLT4/CTNND1/CRKL/GNAI1/ADCY7/RAF1/AKT1/TIAM1/HRAS/MRAS/GNAS/LPAR2/RAPGEF2/CALM3/FGF18/PRKCI/ADCY5/NRAS/RAPGEF3/PIK3R3/EGFR/TEK/AKT2/TLN2/EFNA4/PLCB1/MAPK14/ADCY9/PLCG1/PLCB3/CALML4/P2RY1/RAP1GAP/ANGPT2/CDH1/FGFR3	4.10803079377582
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	59/1692	204/9376	1.60265146247624	FGFR1/ITGA5/FN1/TIMP3/HSPG2/TGFB2/PIK3CB/CTTN/ITPR2/VAV3/MAPK3/PLCG2/PXN/PIK3R2/ERBB3/ERBB2/CBL/AKT3/CAMK2G/TGFB1/VAV2/ITGB1/CD63/PPP1R12C/SLC9A1/PAK1/GRB2/RAF1/FZD8/AKT1/PPP1R12B/PTK2/TIAM1/HRAS/SDC4/MRAS/CTSL/MMP2/ROCK2/GPC3/WNT7A/GPC1/SOS1/RDX/NRAS/FZD5/PIK3R3/EGFR/AKT2/FRS2/MAPK14/PTCH1/TP53/DROSHA/FZD9/FZD10/PLCG1/MTOR/FZD2	4.08358326123629
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	17/1692	37/9376	2.54603539709923	GFPT1/UGDH/GNE/PGM3/UGP2/GALE/GALK1/GMPPA/PMM2/UXS1/GALT/HK1/PGM1/NANS/GFPT2/GALK2/TGDS	4.42142484008806
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	54/1692	184/9376	1.62627197039778	SEMA4C/SEMA7A/PIK3CB/EPHB2/EFNA1/EFNB1/MAPK3/PLCG2/RAC3/EPHB3/PIK3R2/RASA1/NTN4/SEMA4B/SSH2/CAMK2G/BMPR2/PARD6G/ITGB1/PLXNB2/SRGAP2/PARD3/GNAI1/BOC/PAK1/RAF1/NFATC4/PTK2/HRAS/PAK2/SEMA4A/SRGAP1/LIMK2/NRP1/ROCK2/SEMA5A/PLXNA3/NRAS/ROBO3/BMPR1B/ILK/PIK3R3/SLIT3/EFNA4/RYK/PTCH1/L1CAM/SSH3/EFNB2/PLCG1/LRRC4/NTN1/SEMA4G/LRIG2	4.02586324173513
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	49/1692	163/9376	1.66581096172533	HSPG2/CCNE1/TGFB2/DDB1/PIK3CB/MAPK3/PIK3R2/IRF3/CREB3L2/PTK2B/CREB5/AKT3/ATF6B/TGFB1/STAT2/SMAD3/ATF4/MAPK9/FOS/EP300/EGR3/JAK1/GRB2/RAF1/MAP2K7/AKT1/TICAM2/RB1/NFATC4/APAF1/HRAS/IFNAR1/SMAD4/STAT6/TYK2/MAP3K7/TBK1/SOS1/NRAS/TRAF3/PIK3R3/MAVS/AKT2/MAPK14/E2F3/TP53/FADD/JAK2/TAB1	4.02379963644377
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	26/1692	70/9376	2.05822357311719	EPAS1/TGFB2/PIK3CB/MAPK3/PIK3R2/RAPGEF1/AKT3/TGFB1/ARNT2/EGLN3/PDGFB/EP300/CRKL/ARNT/EGLN2/PAK1/GRB2/RAF1/AKT1/HRAS/PAK2/EGLN1/SOS1/NRAS/PIK3R3/AKT2	4.17000971789456
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	45/1692	148/9376	1.68487636572743	FGFR1/TCF7L2/PIK3CB/MAPK3/AXIN2/PIK3R2/ERBB2/AKT3/HEY1/FOS/FLT4/NCOA3/TCF7L1/GRB2/RAF1/FZD8/AKT1/RB1/HRAS/NCOA1/BRCA2/SP1/NOTCH3/CSNK1A1/FRAT2/FGF18/WNT7A/TCF7/SOS1/FRAT1/DVL3/NRAS/FZD5/PIK3R3/EGFR/AKT2/AXIN1/BAK1/E2F3/TP53/FZD9/FZD10/MTOR/LRP6/FZD2	3.94077268014514
NA	NA	hsa04517	IgSF CAM signaling	79/1692	299/9376	1.46410809870569	FGFR1/ITGA5/PTPRF/IL1RAP/ESAM/TUBB2A/PIK3CB/TJP2/F11R/CABLES1/VAV3/TUBB/MAPK3/PLCG2/PXN/ACTN4/ARPC1B/PIK3R2/PVR/MPDZ/JAM2/MYH10/RASA1/TJP1/AKT3/LYN/MYH9/VAV2/FOXO1/NECTIN4/PARD6G/BCAR1/ITGB1/TRIO/PMP22/SRGAP2/MTSS2/PARD3/MAPK9/ERC1/TUBA1C/ACTN1/PPFIA1/GRIP1/PAK1/GRB2/EPB41L3/AKT1/PTK2/PAK2/SRGAP1/GIT1/DYNLL2/TUBB6/RAPGEF2/NRP1/MAG/PRKCI/NLGN2/PLXNA3/RDX/ROBO3/ACTR3B/ARPC2/PTPRS/PIK3R3/SLIT3/AKT2/MTSS1/MAPK14/L1CAM/CD84/DOK1/PLCG1/NTN1/MPP3/CD209/GLDN/CDH1	3.82715201530757
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	47/1692	157/9376	1.65888181174805	PPARG/LRP1/ABCA1/SLC16A1/CEBPB/STAB1/MAPK3/C1QA/ATP11A/CAMK2G/TGFB1/BCAR1/DUSP4/ADAM10/EPOR/C1QB/CRKL/RXRA/ARNT/ELMO1/SGK1/ADAM9/CASP7/NFATC4/PTK2/CPT1B/TGFBRAP1/PPARD/STAB2/VPS39/CPT1A/DUSP16/BSG/RAB5C/ANO6/MAPK14/ANO4/VPS8/VPS18/AGER/DOCK1/ANO9/PLA2G15/JAK2/P2RY6/CH25H/CD24	3.9066776441998
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	50/1692	170/9376	1.62981504658601	CLDN19/CLDN7/TJP2/F11R/CTTN/PRKAG2/SYMPK/ACTN4/ARPC1B/MPDZ/JAM2/MYH10/VASP/ERBB2/AMOTL2/TJP1/ARHGEF2/MYH9/CGNL1/PARD6G/ITGB1/PARD3/MAPK9/TUBA1C/ACTN1/PRKAG1/RAB8B/MAP2K7/TIAM1/MICALL2/SCRIB/SYNPO/RAPGEF2/PRKCE/STK11/ROCK2/DLG1/PRKCI/LLGL2/RDX/ACTR3B/ARPC2/TJAP1/RUNX1/MARVELD2/ARHGEF18/CLDN23/CLDN14/PRKAB2/MYL2	3.88860783424913
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	45/1692	150/9376	1.66241134751773	CCNE1/TCF7L2/TGFB2/PIK3CB/MAPK3/AXIN2/PIK3R2/ERBB2/AKT3/TGFB1/SMAD3/RXRB/RXRA/TCF7L1/GRB2/RAF1/FZD8/AKT1/RB1/HRAS/SMAD4/CSNK1A1/FRAT2/FGF18/WNT7A/TCF7/SOS1/FRAT1/DVL3/NRAS/FZD5/PIK3R3/EGFR/AKT2/AXIN1/BAK1/E2F3/TP53/FZD9/FZD10/MTOR/LRP6/CTNNA3/CDH1/FZD2	3.83759206461249
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	27/1692	77/9376	1.94307819839735	TGFB2/PIK3CB/MAPK3/PIK3R2/CBL/AKT3/TGFB1/SMAD3/CTBP2/CRKL/GRB2/RAF1/AKT1/RB1/HRAS/SMAD4/BCR/SOS1/HDAC1/NRAS/PIK3R3/RUNX1/AKT2/GAB2/BAK1/E2F3/TP53	3.89912432779041
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	31/1692	93/9376	1.84712371946414	FGFR1/PTPRF/TCF7L2/SNAI1/MAPK3/ACTN4/RAC3/CSNK2B/ERBB2/TJP1/NECTIN4/INSR/SMAD3/PARD3/EP300/CTNND1/ACTN1/TCF7L1/SMAD4/SMURF1/ROCK2/MAP3K7/TCF7/CCM2/EGFR/CSNK2A2/PTPRB/FER/CTNNA3/CDH1/MYL2	3.85244352303392
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	31/1692	93/9376	1.84712371946414	COL4A1/COL4A2/FN1/CCNE1/BIRC7/PIK3CB/PIK3R2/AKT3/LAMA5/ITGB1/LAMB1/RXRB/LAMA4/RXRA/AKT1/RB1/PTK2/APAF1/XIAP/LAMC1/TRAF3/CKS1B/PIK3R3/AKT2/ITGA3/NOS2/BAK1/E2F3/TP53/ZBTB17/TRAF2	3.85244352303392
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	38/1692	122/9376	1.72600085261404	PPARG/PIK3CB/FASN/PRKAG2/PIK3R2/CREB3L2/CREB5/AKT3/FOXO1/SREBF1/INSR/PPP2R3B/PFKFB4/PRKAG1/PFKL/EEF2K/EEF2/AKT1/TSC1/GYS1/PPP2R5E/CPT1B/STK11/CPT1A/MAP3K7/TBC1D1/PIK3R3/CAMKK2/AKT2/ACACA/MLYCD/ELAVL1/EIF4EBP1/MTOR/STRADA/ULK1/PRKAB2/RPTOR	3.78742845706299
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	78/1692	300/9376	1.44075650118203	FGFR1/FLT1/PGF/IL1RAP/CSF1R/RASGRF2/TGFB2/EFNA1/DUSP9/MAPK3/MAPK8IP3/IL1R1/RAC3/CACNA1A/RASA1/ERBB3/ERBB2/GNG12/AKT3/TGFB1/PDGFB/INSR/DUSP4/CD14/ATF4/MAPK9/FOS/FLT4/CRKL/MAP3K10/PAK1/GRB2/RAF1/MAP2K7/AKT1/SRF/HRAS/PAK2/GNA12/MRAS/RPS6KA1/TAOK3/TAOK1/RASGRF1/DUSP1/NF1/RAPGEF2/FGF18/MAP3K7/DUSP16/SOS1/MKNK1/NRAS/MAP3K14/EGFR/PTPRR/TEK/MAP4K3/AKT2/EFNA4/RPS6KA5/TAOK2/MAPK14/TP53/MAP3K9/MAP4K2/CACNA1C/MAP3K4/MAPT/CACNB3/PPP5C/TAB1/STK3/PLA2G4B/TRAF2/TRADD/ANGPT2/FGFR3	3.64086226794931
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	34/1692	106/9376	1.77742093759757	FGFR1/CCNE1/TCF7L2/PIK3CB/MAPK3/PIK3R2/CREB3L2/CREB5/ERBB2/AKT3/FOXO1/PDGFB/FOLR2/ATF4/EP300/FOLR1/TCF7L1/GRB2/ETV5/RAF1/AKT1/RB1/HRAS/IL1R2/TCF7/SOS1/NRAS/NKX3-1/PIK3R3/EGFR/AKT2/E2F3/TP53/MTOR	3.77712569886587
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	63/1692	232/9376	1.50476889214967	FGFR1/ITGA5/FN1/PIK3CB/VAV3/MAPK3/PXN/ACTN4/ARPC1B/RAC3/PIK3R2/MYH10/GNG12/CHRM5/SSH2/AKT3/MYH9/VAV2/BCAR1/ITGB1/PDGFB/PPP1R12C/ARHGEF7/CRKL/CYFIP1/SLC9A1/ACTN1/CYFIP2/PAK1/RAF1/AKT1/PPP1R12B/PTK2/TIAM1/HRAS/PAK2/GNA12/MRAS/PIP4K2B/GIT1/LIMK2/NCKAP1/LPAR2/ROCK2/FGF18/SOS1/RDX/NRAS/ACTR3B/PIKFYVE/ARPC2/PIK3R3/EGFR/AKT2/ARHGEF4/ITGA3/SSH3/DIAPH2/PIP4K2C/DOCK1/C9/MYL2/FGFR3	3.65309196571632
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	32/1692	98/9376	1.8094273170261	ASAP3/PIK3CB/INPPL1/DNM2/VAV3/MAPK3/PLCG2/ARPC1B/PIK3R2/VASP/MYO10/AKT3/LYN/VAV2/CRKL/PLPP2/PAK1/RAF1/AKT1/LIMK2/PRKCE/ACTR3B/ARPC2/FCGR3A/PIK3R3/AKT2/GAB2/PLCG1/PLD2/FCGR2B/DOCK1/PLA2G4B	3.77968711672003
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	27/1692	78/9376	1.91816693944354	ITGA5/FN1/PIK3CB/CTTN/DNM2/PXN/ARPC1B/PIK3R2/SEPTIN3/CBL/CLTB/BCAR1/ITGB1/ARHGAP10/CRKL/ELMO1/PTK2/SEPTIN9/ACTR3B/ARPC2/ILK/PIK3R3/DOCK1/ELMO2/SEPTIN8/CTNNA3/CDH1	3.82090571288361
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	10/1692	18/9376	3.07853953244024	HEXB/GLB1/HEXA/MAN2B2/AGA/MAN2B1/FUCA2/GBA2/ENGASE/MAN2C1	4.14185757168734
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	11/1692	21/9376	2.90262298772937	CHPF/DSEL/B4GALT7/XYLT1/CHST11/CHPF2/CSGALNACT1/CHST14/B3GALT6/XYLT2/B3GAT3	4.09574236690559
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	32/1692	99/9376	1.79115027341978	PIK3CB/MAPK3/PIK3R2/ERBB2/AKT3/CARM1/MAPK9/FOS/ADCY7/NCOA3/GRB2/RAF1/AKT1/RB1/PTK2/HRAS/GNAS/SP1/NOTCH3/MMP2/ADCY5/SOS1/NRAS/PIK3R3/EGFR/NCOR1/AKT2/MAPK14/E2F3/ADCY9/TP53/MTOR	3.71334192506267
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	32/1692	99/9376	1.79115027341978	DGKZ/PIK3CB/MAPK3/RAC3/PIK3R2/AKT3/CHKB/PDGFB/MAPK9/FOS/PLPP2/LYPLA1/GRB2/RAF1/AKT1/TSC1/HRAS/SP1/SOS1/NRAS/PIK3R3/EGFR/SLC44A5/AKT2/EIF4EBP1/DGKH/PLCG1/PLD2/MTOR/DGKQ/PLA2G4B/SLC22A4	3.71334192506267
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	28/1692	83/9376	1.86937822210829	CSNK2B/BCORL1/JARID2/MGA/EP300/RING1/L3MBTL3/PHC2/PCGF2/SKP1/HCFC1/PCGF3/CBX3/L3MBTL1/BCOR/BMI1/DCAF7/SFMBT1/HDAC1/FOXK2/PHC1/EED/BAP1/ASXL2/CBX8/RBBP7/UBE2D4/L3MBTL2	3.73303424546467
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	48/1692	169/9376	1.57388056569726	CTSB/PIK3CB/MAPK3/PIK3R2/AKT3/WIPI1/SNAP29/MAPK9/EIF2AK4/PLEKHM1/LAMP2/ATG9A/GORASP2/DAPK3/RAF1/AKT1/MTMR4/TSC1/HRAS/MRAS/ATG13/CTSL/SMCR8/ATG16L1/YKT6/STK11/RAB1A/BIRC6/VPS39/MAP3K7/TBK1/LAMP1/NRAS/PIK3R3/ATG2B/DEPTOR/GORASP1/CAMKK2/AKT2/WIPI2/EPG5/PIK3C3/MTMR3/ULK2/VPS18/MTOR/ULK1/RPTOR	3.53262825252487
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	66/1692	250/9376	1.4629219858156	ASAP3/IQSEC1/HLA-G/GRK3/DNM2/ARFGAP1/ARPC1B/AP2A2/VPS28/IL2RB/SH3GL1/CBL/IGF2R/EHD3/SH3GL3/CBLB/CLTB/PARD6G/SMAD3/ITCH/CYTH3/FOLR2/PARD3/SNX5/TFRC/ARF4/FOLR1/GBF1/ARAP1/EPN2/HRAS/HGS/ARFGEF1/WASHC1/GIT1/SMURF1/VPS36/GRK5/WIPF2/PRKCI/ARFGEF2/EPN1/ZFYVE9/DAB2/ACTR3B/RAB5C/ARPC2/ACAP3/WASHC4/EGFR/SNX4/CHMP1A/MVB12B/AGAP5/GRK4/CYTH2/PLD2/STAM2/WASHC5/VPS25/ZFYVE27/AGAP9/MVB12A/AGAP4/FGFR3/CHMP7	3.48120596525271
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	34/1692	109/9376	1.72850109527837	PTPRF/PIK3CB/GFPT1/PRKAG2/PIK3R2/CREB3L2/SLC27A1/CREB5/TBC1D4/AKT3/FOXO1/SREBF1/INSR/MLXIP/PPP1R3B/MAPK9/PRKAG1/AKT1/GYS1/RPS6KA1/CPT1B/PRKCE/OGA/PPP1R3D/CPT1A/PPARA/PIK3R3/SLC27A3/AKT2/GFPT2/PTPA/MTOR/PYGB/PRKAB2	3.58976497578508
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	30/1692	93/9376	1.7875390833524	MMP14/ITPR2/MAPK3/PTK2B/CGA/CAMK2G/ATF4/MAPK9/ADCY7/GRB2/RAF1/MAP2K7/HRAS/GNAS/MMP2/CALM3/ADCY5/SOS1/NRAS/EGFR/PLCB1/MAPK14/ADCY9/GNA11/PLD2/CACNA1C/MAP3K4/PLCB3/CALML4/PLA2G4B	3.58147195160132
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	48/1692	170/9376	1.56462244472257	TCF7L2/TGFB2/PIK3CB/SMARCB1/HMOX1/MAPK3/PLCG2/AXIN2/PIK3R2/AKT3/TGFB1/GSTA3/SMAD3/SMARCA4/TCF7L1/GRB2/RAF1/FZD8/PBRM1/AKT1/RB1/HRAS/SMAD4/SMARCD2/CSNK1A1/FRAT2/SMARCC1/SMARCC2/WNT7A/TCF7/SOS1/FRAT1/DVL3/NRAS/FZD5/PIK3R3/EGFR/AKT2/AXIN1/BAK1/E2F3/TP53/FZD9/FZD10/PLCG1/MTOR/LRP6/FZD2	3.48609528121402
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	43/1692	149/9376	1.59918764973741	DGKZ/PIK3CB/DNM2/MAPK3/PLCG2/AGTR1/PIK3R2/PTK2B/AKT3/PDGFB/INSR/CYTH3/AGPAT1/ADCY7/PLPP2/GRB2/RAF1/AKT1/TSC1/HRAS/GNA12/MRAS/GNAS/LPAR2/ADCY5/SOS1/NRAS/RAPGEF3/PIK3R3/EGFR/LPAR6/AKT2/GAB2/PLCB1/DGKH/ADCY9/CYTH2/PLCG1/PLD2/MTOR/DGKQ/PLCB3/PLA2G4B	3.45953609848189
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	28/1692	86/9376	1.80416735389521	PIK3CB/MAPK3/PLCG2/PIK3R2/ERBB3/ERBB2/CBL/AKT3/CBLB/CAMK2G/MAPK9/CRKL/PAK1/GRB2/RAF1/MAP2K7/AKT1/PTK2/HRAS/PAK2/SOS1/NRAS/PIK3R3/EGFR/AKT2/EIF4EBP1/PLCG1/MTOR	3.51544207653691
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	40/1692	137/9376	1.61791858639195	CSF2RB/DAB2IP/CTSB/PIK3CB/ITPR2/MAPK3/TNFSF10/PIK3R2/CTSV/AKT3/ENDOG/ATF4/MAPK9/FOS/TUBA1C/DFFB/PTPN13/RAF1/AKT1/CASP7/APAF1/HRAS/ATM/XIAP/CASP2/CTSL/CTSO/NRAS/CTSZ/MAP3K14/PIK3R3/AKT2/BAK1/RIPK1/TP53/FADD/LMNB2/TRAF2/TRADD/PIDD1	3.41878034159659
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	41/1692	142/9376	1.59997336263444	DDB1/BIRC7/HERC1/UBE2K/CBL/CBLB/ITCH/UBE2H/HERC2/PPIL2/TRIP12/UBE2Q2/SYVN1/UBE2A/CDC34/SKP1/HERC3/UBE2Z/XIAP/UBR5/SMURF1/SIAH1/BIRC6/CUL4B/UBE2L6/MGRN1/UBE2O/HERC4/PRPF19/WWP2/CUL1/FBXW8/TRIM37/UBE3C/KLHL9/ANAPC13/UBA7/DET1/SAE1/UBE3B/UBE2D4	3.38044088542926
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	28/1692	87/9376	1.78342979810331	TCF7L2/TGFB2/PIK3CB/MAPK3/AXIN2/RAC3/PIK3R2/AKT3/TGFB1/SMAD3/MAPK9/FOS/TCF7L1/GRB2/RAF1/AKT1/HRAS/SMAD4/TCF7/SOS1/NRAS/PIK3R3/EGFR/AKT2/AXIN1/BAK1/TP53/MTOR	3.4448266352437
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	22/1692	63/9376	1.93508199181958	PLOD2/PLOD3/PIPOX/KMT2C/PLOD1/COLGALT1/EHMT2/DOT1L/NSD3/NSD1/ASH1L/KMT2D/SUV39H1/KMT5C/SETD1B/ALDH1B1/SETD1A/KMT2B/AADAT/SUV39H2/ALDH3A2/SETDB1	3.49435726938296
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	24/1692	71/9376	1.87313954649885	FGFR1/SLC16A3/PIK3CB/IDH2/MAPK3/PIK3R2/ERBB2/AKT3/LDHA/PFKL/RAF1/AKT1/HRAS/HK1/NRAS/IDH1/PIK3R3/EGFR/AKT2/TIGAR/TP53/MTOR/PDK1/FGFR3	3.46534743931505
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	41/1692	144/9376	1.57775151037562	PIK3CB/ITPR2/PIK3R2/CACNA1A/XBP1/AKT3/PSMC4/WIPI1/PSMA2/MAPK9/PSMA6/AKT1/ATXN2/PUM1/ATG13/SP1/SLC1A6/NFYA/PIK3R3/ATG2B/BEAN1/AKT2/WIPI2/PUM2/VLDLR/PLCB1/SLC25A4/PIK3C3/ULK2/KAT5/GRIN2D/MTOR/ATXN1L/ULK1/PLCB3/TBP/PSMA8/AFG3L2/TRAF2/GRIN3B/TBPL1	3.27843499670029
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	31/1692	101/9376	1.70081689019966	COL4A1/COL4A2/FN1/TGFB2/PIK3CB/MAPK3/PLCG2/AGTR1/PIK3R2/AKT3/TGFB1/FOXO1/SMAD3/SERPINE1/MAPK9/AKT1/HRAS/SMAD4/MMP2/PRKCE/NRAS/PIK3R3/AKT2/PLCD3/PLCB1/MAPK14/PLCG1/AGER/PLCB3/JAK2/NOX4	3.32277112140523
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	54/1692	203/9376	1.47405932292213	ITGA5/SPP1/COL4A1/COL4A2/FLT1/FN1/PGF/PIK3CB/VAV3/MAPK3/PARVA/PXN/ACTN4/RAC3/PIK3R2/VASP/ERBB2/FLNB/RAPGEF1/AKT3/VAV2/LAMA5/BCAR1/ITGB1/PDGFB/TLN1/LAMB1/MAPK9/PPP1R12C/FLT4/CRKL/LAMA4/ACTN1/PAK1/GRB2/RAF1/AKT1/PPP1R12B/PTK2/HRAS/PAK2/XIAP/RASGRF1/LAMC1/ROCK2/SOS1/ILK/PIK3R3/EGFR/AKT2/TLN2/ITGA3/DOCK1/MYL2	3.20418183165996
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	33/1692	110/9376	1.66241134751773	FLT1/EPAS1/PIK3CB/HMOX1/MAPK3/PLCG2/PIK3R2/ERBB2/AKT3/CAMK2G/LDHA/EGLN3/INSR/SERPINE1/EP300/TFRC/ARNT/EGLN2/PFKL/AKT1/EGLN1/HK1/MKNK1/PIK3R3/EGFR/TEK/AKT2/NOS2/EIF4EBP1/PLCG1/MTOR/ANGPT2/PDK1	3.27921655381956
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	25/1692	77/9376	1.79914647999754	TGFB2/PIK3CB/MAPK3/RAC3/PIK3R2/ERBB2/AKT3/TGFB1/SMAD3/MAPK9/RALBP1/JAK1/RAF1/AKT1/RB1/SMAD4/BRCA2/PIK3R3/EGFR/AKT2/BAK1/E2F3/TP53/PLD2/MTOR	3.30404359566548
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	23/1692	69/9376	1.84712371946414	PIK3CB/VAV3/MAPK3/PLCG2/RAC3/PIK3R2/AKT3/LYN/VAV2/MAPK9/GRB2/RAF1/MAP2K7/AKT1/HRAS/SOS1/NRAS/PIK3R3/AKT2/GAB2/MAPK14/PLCG1/PLA2G4B	3.31404705120342
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	22/1692	65/9376	1.8755410074559	SPP1/PIK3CB/ITPR2/MAPK3/PIK3R2/CGA/AKT3/RAF1/AKT1/HRAS/KISS1R/NRAS/PIK3R3/AKT2/PLCB1/KCNN2/KCNJ6/GNA11/CACNA1C/KCNJ5/PLCB3/HCN3	3.32374078502323
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	38/1692	133/9376	1.58324890239784	TGFB2/PIK3CB/FBXO32/PRKAG2/MAPK3/TNFSF10/PIK3R2/PLK2/CCNG2/CSNK1E/AKT3/TGFB1/HOMER1/FOXO1/INSR/SMAD3/DEPP1/MAPK9/EP300/SGK1/PRKAG1/GRB2/RAF1/AKT1/HRAS/SMAD4/ATM/FOXO4/STK11/PLK3/SOS1/NRAS/RBL2/PIK3R3/EGFR/AKT2/MAPK14/PRKAB2	3.17881617058991
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	39/1692	138/9376	1.56603967519786	ITGA5/FN1/PIK3CB/VAV3/MAPK3/PXN/ARPC1B/RAC3/PIK3R2/IRF3/PTK2B/AKT3/PKN1/VAV2/BCAR1/ITGB1/MAPK9/FOS/ARHGEF7/CRKL/ELMO1/MAP2K7/AKT1/PTK2/RPS6KA1/ROCK2/WIPF2/MAP3K7/TBK1/ACTR3B/ARPC2/PIK3R3/AKT2/MAPK14/PLCG1/DOCK1/TAB1/ELMO2/TRAF2	3.1433270999564
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	8/1692	15/9376	2.95539795114263	HEXB/GLB1/HEXA/ST3GAL5/B3GALT4/ST8SIA1/ST6GALNAC6/SLC33A1	3.55640983151401
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	51/1692	193/9376	1.46430015066329	GRK3/PIK3CB/VAV3/CCL3/MAPK3/PLCG2/PXN/RAC3/PIK3R2/PTK2B/GNG12/CCR1/AKT3/LYN/CCL4/CCL4L2/VAV2/STAT2/BCAR1/PARD3/CXCR6/CRKL/GNAI1/ELMO1/XCR1/ADCY7/PAK1/GRB2/RAF1/AKT1/PTK2/TIAM1/HRAS/ROCK2/GRK5/ADCY5/SOS1/NRAS/PIK3R3/AKT2/GSK3A/PLCB1/GRK4/ADCY9/PLCG1/PLCB3/JAK2/CCL8/CCL13/CXCL10/CCL28	3.05828057591919
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	43/1692	157/9376	1.51770038096099	TCF7L2/TGFB2/LIMD1/AXIN2/TEAD1/DLG5/CSNK1E/TGFB1/ID1/BMPR2/PARD6G/SMAD3/SERPINE1/PARD3/TCF7L1/TEAD3/FZD8/SMAD4/SCRIB/RASSF6/WWTR1/DLG1/PRKCI/LLGL2/WNT7A/TCF7/DVL3/SAV1/LATS1/BMPR1B/MOB1B/FZD5/AXIN1/AMH/FZD9/FZD10/FRMD6/AJUBA/STK3/WTIP/CTNNA3/CDH1/FZD2	3.06957707533042
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	92/1692	388/9376	1.31393336745388	BACE2/SLC39A1/TUBB2A/LRP1/MME/PIK3CB/ITPR2/SLC39A7/TUBB/NCSTN/MAPK3/AXIN2/PIK3R2/CSNK2B/NDUFA6/XBP1/CHRM5/CSNK1E/AKT3/NDUFS1/PSMC4/WIPI1/PSMA2/INSR/NDUFS3/ADAM10/SLC39A14/ATF4/MAPK9/SLC39A4/NDUFA7/TUBA1C/PSMA6/RAF1/FZD8/MAP2K7/AKT1/CASP7/APAF1/HRAS/ATG13/TUBB6/SDHA/SLC39A11/CSNK1A1/FRAT2/CALM3/APOE/WNT7A/FRAT1/DVL3/NRAS/SLC39A6/SLC11A2/FZD5/PIK3R3/MT-ND2/ATG2B/NDUFA13/AKT2/WIPI2/NOS2/AXIN1/CSNK2A2/SLC39A9/PLCB1/MT-ND5/SLC25A4/PIK3C3/SLC39A13/APH1B/ULK2/FZD9/FZD10/GRIN2D/MTOR/COX4I2/LRP6/CACNA1C/MAPT/AGER/FADD/ULK1/PSEN2/PLCB3/CALML4/PSMA8/IDE/TRAF2/FZD2/NOX4/MT-ND1	2.9635615327313
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	30/1692	101/9376	1.64595182922548	TCF7L2/POMC/MAPK3/CREB3L2/EDNRB/CAMK2G/EP300/GNAI1/ADCY7/TCF7L1/RAF1/FZD8/HRAS/MITF/GNAS/CALM3/ADCY5/WNT7A/TCF7/DVL3/NRAS/FZD5/PLCB1/ADCY9/FZD9/FZD10/MC1R/PLCB3/CALML4/FZD2	3.06264034726362
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	32/1692	110/9376	1.6120352460778	TGFB2/BAMBI/MAPK3/FST/LRRC32/TGFB1/ID1/BMPR2/FBN1/SMAD3/ID3/EP300/NOG/TFRC/RGMB/INHBA/SKP1/SMAD4/E2F4/LTBP1/SP1/SMURF1/ZFYVE9/HDAC1/BMPR1B/ACVR1/NCOR1/CUL1/AMH/SMAD6/GREM1/ACVR2B	3.02983352863777
Human Diseases	Cancer: specific types	hsa05214	Glioma	24/1692	76/9376	1.74990668159761	PIK3CB/MAPK3/PLCG2/PIK3R2/AKT3/CAMK2G/PDGFB/GRB2/RAF1/AKT1/RB1/HRAS/CALM3/SOS1/NRAS/PIK3R3/EGFR/AKT2/BAK1/E2F3/TP53/PLCG1/MTOR/CALML4	3.08009906183277
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	55/1692	214/9376	1.42418417622235	HLA-G/DDB1/PIK3CB/ITPR2/MAPK3/PLCG2/PXN/TAPBP/RAC3/PIK3R2/IRF3/TAP1/TAP2/PTK2B/GNG12/AKT3/MAPK9/FOS/CRKL/GNAI1/TAPBPL/PAK1/SKP1/RAF1/MAP2K7/AKT1/NFATC4/PTK2/HRAS/PAK2/PDIA3/ATM/LIMK2/CALM3/MAP3K7/CUL4B/AP1B1/TBK1/NRAS/PIK3R3/CUL1/AKT2/BAK1/MAPK14/RIPK1/GNA11/PLCG1/MTOR/FADD/AP1G2/CALML4/TAB1/ATR/TRAF2/TRADD	2.94549538052918
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	22/1692	68/9376	1.79279655124461	CSF1R/TCF7L2/PIK3CB/MAPK3/PIK3R2/CEBPA/AKT3/CD14/TCF7L1/GRB2/RAF1/AKT1/HRAS/PPARD/TCF7/SOS1/NRAS/PIK3R3/RUNX1/AKT2/EIF4EBP1/MTOR	3.078790662587
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	51/1692	196/9376	1.44188739325517	TCF7L2/HLA-G/PIK3CB/IFNAR2/ITPR2/MAPK3/PLCG2/PIK3R2/IRF3/GNG12/CCR1/AKT3/LYN/STAT2/IL6ST/PDGFB/MAPK9/FOS/EP300/JAK1/TCF7L1/RAF1/MAP2K7/AKT1/RB1/NFATC4/HRAS/IFNAR1/RCAN1/CALM3/TYK2/TBK1/TCF7/NRAS/TRAF3/PIK3R3/AKT2/BAK1/MAPK14/E2F3/PIK3C3/TP53/PLCG1/MTOR/CD200R1/FADD/CALML4/JAK2/TRAF2/TRADD/ANGPT2	2.93366450422854
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	9/1692	19/9376	2.62486002239642	NAGLU/HEXB/GLB1/HEXA/HGSNAT/HYAL4/ARSB/GUSB/GALNS	3.3267225247161
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	42/1692	155/9376	1.50153283001601	SCARB1/CCNE1/TCF7L2/POMC/CYP11A1/ITPR2/MAPK3/AXIN2/AGTR1/CREB3L2/CREB5/ATF6B/CAMK2G/ATF4/ARNT/GNAI1/ADCY7/TCF7L1/FZD8/RB1/GNAS/SP1/KMT2D/ADCY5/WNT7A/TCF7/DVL3/FZD5/EGFR/AXIN1/PLCB1/E2F3/ADCY9/GNA11/FZD9/FZD10/ASH2L/CACNA1C/MEN1/PLCB3/CRH/FZD2	2.95439353610577
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	57/1692	224/9376	1.41008105369807	CCNE1/HLA-G/TGFB2/PIK3CB/MAPK3/IL1R1/PIK3R2/CREB3L2/CREB5/IL2RB/CRTC3/CANX/AKT3/ATF6B/TGFB1/SMAD3/TLN1/ATF4/MAPK9/FOS/EP300/JAK1/ADCY7/AKT1/RB1/NFATC4/SRF/HRAS/SMAD4/IL1R2/ATM/XIAP/NRP1/DLG1/ADCY5/NRAS/MAP3K14/PIK3R3/HLA-DQA1/AKT2/TLN2/TCF3/MSX2/KAT2A/E2F3/SLC25A4/ADCY9/TP53/ANAPC13/TRRAP/NFYB/KAT5/VAC14/TBP/RANBP3/ATR/TBPL1	2.91492810531992
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	42/1692	156/9376	1.49190761956719	CLDN19/SCARB1/CLDN7/PIK3CB/IFNAR2/MAPK3/PIK3R2/IRF3/AKT3/STAT2/OAS3/RXRA/JAK1/GRB2/RAF1/AKT1/OAS1/RB1/APAF1/HRAS/IFNAR1/IFIT1/TYK2/TBK1/SOS1/NRAS/TRAF3/PPARA/PIK3R3/MAVS/EGFR/AKT2/BAK1/E2F3/RIPK1/TP53/CLDN23/CLDN14/FADD/TRAF2/CXCL10/TRADD	2.90718405411166
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/1692	41/9376	2.02733091160699	MAPK3/ERBB2/TYMP/DAPK3/RAF1/RB1/HRAS/MMP2/NRAS/EGFR/RPS6KA5/E2F3/TP53/CDH1/FGFR3	3.09340841478296
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	38/1692	139/9376	1.51490722315764	POMC/PIK3CB/ITPR2/MAPK3/PIK3R2/CREB3L2/CREB5/AKT3/ATF6B/ATF4/FOS/KRT23/GNAI1/ADCY7/NCOA3/GRB2/RAF1/AKT1/HRAS/NCOA1/GNAS/SP1/MMP2/CALM3/ADCY5/SOS1/NRAS/PIK3R3/EGFR/NCOA2/AKT2/KRT15/PLCB1/ADCY9/KCNJ6/KCNJ5/PLCB3/CALML4	2.86987546852284
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	39/1692	144/9376	1.50078802206462	TCF7L2/FASN/PRKAG2/IRF3/C1QA/LPIN2/AKT3/FOXO1/SREBF1/C1QB/CD14/MAPK9/ACADVL/PRKAG1/TCF7L1/MAP2K7/AKT1/CPT1B/C3AR1/CPT1A/MAP3K7/TBK1/TCF7/TRAF3/MAP3K14/PPARA/ALDH1B1/CAMKK2/AKT2/ACACA/MLYCD/MAPK14/RIPK1/FADD/ALDH3A2/PRKAB2/TAB1/TRADD/NOX4	2.84170780686933
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	42/1692	158/9376	1.47302271299039	PIK3CB/GRB10/MAPK3/CASTOR1/PIK3R2/SESN2/LPIN2/AKT3/INSR/SGK1/SLC38A9/GRB2/RAF1/FZD8/AKT1/TSC1/HRAS/RPS6KA1/STK11/WNT7A/SOS1/CASTOR2/DVL3/NRAS/FZD5/WDR59/PIK3R3/DEPTOR/AKT2/EIF4EBP1/ULK2/FZD9/FZD10/MTOR/STRADA/LRP6/ULK1/ATP6V1C2/DEPDC5/ATP6V1E2/FZD2/RPTOR	2.81374233973563
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	20/1692	62/9376	1.7875390833524	PIK3CB/PRKAG2/PIK3R2/EIF4EBP2/AKT3/FOXO1/INSR/PRKAG1/ADCY7/AKT1/HRAS/ADCY5/HDAC1/NRAS/PIK3R3/AKT2/ADCY9/MTOR/PRKAB2/RPTOR	2.91938910696584
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	31/1692	109/9376	1.57598629275381	SPP1/PIK3CB/IFNAR2/CCL3/MAPK3/PIK3R2/IRF3/AKT3/CCL4/CCL4L2/STAT2/CD14/MAPK9/FOS/JAK1/MAP2K7/AKT1/TICAM2/IFNAR1/TYK2/MAP3K7/TBK1/TRAF3/PIK3R3/AKT2/MAPK14/RIPK1/FADD/TAB1/CXCL10/TLR7	2.83823241126334
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	61/1692	248/9376	1.3629985510562	TCF7L2/TUBB2A/PIK3CB/DNM2/TUBB/MAPK3/GSDMD/TNFSF10/ARPC1B/AKT3/PKN1/CYTH3/CD14/MAPK9/FOS/CYFIP1/DYNLRB1/TUBA1C/PLEKHM1/SNX9/ELMO1/CYFIP2/RHOB/TCF7L1/PAK1/SKP1/RAF1/MAP2K7/AKT1/CASP7/PLEKHM2/HRAS/DYNC1LI2/DYNLL2/TUBB6/NCKAP1/ROCK2/PIK3C2A/VPS39/MAP3K7/TCF7/RILP/ACTR3B/RAB5C/PIK3C2B/ARPC2/AKT2/DCTN1/FBXO22/BAK1/MAPK14/RIPK1/PIK3C3/CYTH2/VPS18/FADD/TAB1/ELMO2/TRAF2/TRADD/MYL2	2.71853579461615
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	33/1692	119/9376	1.53668275820967	MMP14/DAB2IP/PIK3CB/CEBPB/MAPK3/PIK3R2/CREB3L2/CREB5/AKT3/ATF6B/ITCH/ATF4/MAPK9/FOS/MAP2K7/AKT1/CASP7/XIAP/FRMD8/MAP3K7/RHBDF1/TRAF3/MAP3K14/PIK3R3/AKT2/RPS6KA5/MAPK14/RIPK1/FADD/TAB1/TRAF2/CXCL10/TRADD	2.76470075672249
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	24/1692	80/9376	1.66241134751773	PIK3CB/MAPK3/PLCG2/PIK3R2/ERBB3/ERBB2/AKT3/PDGFB/JAK1/GRB2/RAF1/AKT1/HRAS/NF1/SOS1/NRAS/PIK3R3/EGFR/AKT2/EIF4EBP1/PLCG1/MTOR/JAK2/FGFR3	2.79200916142072
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	33/1692	120/9376	1.52387706855792	PIK3CB/MAPK3/PLCG2/PIK3R2/MAGED1/RAPGEF1/AKT3/CAMK2G/SH2B2/ATF4/MAPK9/CRKL/BEX3/GRB2/RAF1/MAP2K7/AKT1/HRAS/RPS6KA1/CALM3/SOS1/NRAS/PIK3R3/AKT2/RPS6KA5/FRS2/MAPK14/TP53/PLCG1/PSEN2/ZNF274/CALML4/SH2B1	2.71019461601094
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	12/1692	32/9376	2.07801418439716	GAA/AKR1B1/GALM/GLB1/UGP2/GALE/GALK1/PFKL/GALT/HK1/B4GALT2/PGM1	2.86632339901609
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	35/1692	130/9376	1.49190761956719	COL4A1/COL4A2/PIK3CB/MAPK3/PIK3R2/CREB3L2/EDNRB/CREB5/GNG12/AKT3/ATF6B/TGFB1/ATF4/MAPK9/FOS/GNAI1/ADCY7/GRB2/RAF1/MAP2K7/AKT1/HRAS/GNAS/MMP2/ADCY5/SOS1/NRAS/PIK3R3/EGFR/AKT2/NOS2/PLCB1/MAPK14/ADCY9/PLCB3	2.65014978564225
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	22/1692	73/9376	1.67000226691279	PIK3CB/MAPK3/PLCG2/PIK3R2/ERBB2/AKT3/RXRB/RXRA/GRB2/RAF1/AKT1/RB1/HRAS/SOS1/NRAS/PIK3R3/EGFR/AKT2/BAK1/E2F3/TP53/PLCG1	2.69661118249796
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	50/1692	200/9376	1.38534278959811	CLDN19/TUBB2A/CLDN7/CTTN/SEC24D/BAIAP2L1/TUBB/MAPK3/TNFSF10/IL1R1/ARPC1B/MYH10/TJP1/MYO10/ARHGEF2/MYH9/ITGB1/CYTH3/SEC24A/MAPK9/FOS/CYFIP1/TUBA1C/CYFIP2/PAK1/CASP7/PAK2/GNA12/TMBIM6/TUBB6/NCKAP1/LPAR2/RAB1A/ROCK2/SEC24C/WIPF2/MAP3K7/MYO1C/ACTR3B/ARPC2/BAK1/MAPK14/RIPK1/CYTH2/CLDN23/CLDN14/FADD/TAB1/TRAF2/TRADD	2.58480432607977
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	37/1692	140/9376	1.464505234718	SPP1/ITPR2/PRKAG2/MAPK3/AGTR1/GNG12/AKT3/HDAC5/SMAD3/SERPINE1/SLC9A1/GNAI1/PRKAG1/ADCY7/RAF1/AKT1/HRAS/MRAS/SMAD4/NOTCH3/PRKCE/CALM3/ADCY5/NRAS/AKT2/NOS2/TFAM/PLCB1/ADCY9/PIK3C3/MTOR/PLCB3/CALML4/PRKAB2/MEF2B/CDH1/MYL2	2.59839282173386
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/1692	37/9376	1.94696824484059	PPARG/TCF7L2/MAPK3/RXRB/RXRA/TCF7L1/NCOA4/HRAS/TCF7/NRAS/BAK1/TP53/CDH1	2.70818438463219
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	21/1692	70/9376	1.66241134751773	POMC/PRKAG2/ACSL4/AKT3/RXRB/MAPK9/RXRA/PRKAG1/ACSL5/AKT1/CPT1B/STK11/CPT1A/PPARA/CAMKK2/AKT2/MTOR/PRKAB2/JAK2/TRAF2/TRADD	2.61028182187987
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	31/1692	115/9376	1.49376092095796	FGFR1/GCM1/MMP14/ITPR2/WNK2/MAPK3/CREB3L2/CREB5/GATA3/ATF6B/RXRB/ATF4/FOS/RXRA/GNAI1/SGK1/MMP15/ADCY7/RAF1/GNA12/GNAS/SP1/ADCY5/PTH1R/EGFR/PLCB1/ADCY9/GNA11/PLD2/LRP6/PLCB3	2.49993566249027
NA	NA	hsa04519	Cadherin signaling	91/1692	404/9376	1.24818013716265	FGFR1/KRT7/TCF7L2/LIMD1/VAV3/LHFPL6/NCSTN/MAPK3/AXIN2/ACTN4/ARPC1B/RAC3/MPDZ/ANKRD6/PKP2/CTNND2/PTK2B/VASP/ERBB2/LIMA1/AMOTL2/TJP1/TEAD1/FMN1/FAT2/TMC4/EVL/VAV2/RERE/ADAM10/GABRE/MAPK9/EP300/FLT4/CTNND1/CYFIP1/TMC1/KRT23/ACTN1/CYFIP2/TCF7L1/TEAD3/RAF1/FZD8/PTK2/HRAS/MRAS/TAOK3/TAOK1/NCKAP1/CSNK1A1/ROCK2/WWTR1/ATN1/WNT7A/TCF7/CDH8/DVL3/NRAS/MYO1C/SAV1/LATS1/ACTR3B/ARPC2/MOB1B/FZD5/PCDH12/DAAM2/EGFR/AXIN1/KRT15/TAOK2/RYK/MAPK14/APH1B/FZD9/FZD10/DSP/CDH23/LRP6/LHFPL5/PSEN2/AJUBA/MYO7A/CELSR2/STK3/WTIP/FAT1/CTNNA3/CDH1/FZD2	2.39279344235718
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	40/1692	157/9376	1.41181430787068	CCNE1/HLA-G/TGFB2/PIK3CB/ITPR2/MAPK3/PIK3R2/RAD50/AKT3/TGFB1/FOXO1/IGFBP3/SMAD3/SERPINE1/RAF1/AKT1/RB1/NFATC4/TSC1/HRAS/MRAS/E2F4/ATM/CALM3/TRPM7/NRAS/RBL2/LIN37/PIK3R3/ZFP36L1/TRPV4/AKT2/EIF4EBP1/MAPK14/E2F3/SLC25A4/TP53/MTOR/CALML4/ATR	2.44175164867839
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	31/1692	116/9376	1.48088367163936	CLDN19/ESAM/CLDN7/PIK3CB/F11R/VAV3/PLCG2/PXN/ACTN4/PIK3R2/JAM2/PTK2B/VASP/VAV2/BCAR1/ITGB1/CTNND1/GNAI1/ACTN1/PTK2/CD99L2/MMP2/ROCK2/RAPGEF3/PIK3R3/MAPK14/CLDN23/PLCG1/CLDN14/CTNNA3/MYL2	2.44543245442364
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	29/1692	107/9376	1.50186694947085	ITPR2/PRKAG2/CREB3L2/CREB5/AKT3/CAMK2G/LDHA/FOXO1/ATF4/EP300/PHKA2/PRKAG1/PFKL/AKT1/GYS1/CPT1B/GNAS/CALM3/CPT1A/PPARA/PHKB/SIK2/AKT2/ACACA/PLCB1/PLCB3/PYGB/CALML4/PRKAB2	2.44994414548741
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	28/1692	103/9376	1.50639215956299	COL4A1/COL4A2/FN1/TGFB2/SERPINB6/PIK3CB/ACTN4/IL1R1/PIK3R2/TGFB1/LAMA5/LAMB1/CD14/LAMA4/ACTN1/PTK2/IL1R2/PRDX1/LAMC1/GNAS/RAB5C/PIK3R3/NOS2/PLCB1/GNAL/GNA11/PLCB3/C9	2.42486516626964
NA	NA	hsa04518	Integrin signaling	39/1692	154/9376	1.40333425439808	ITGA5/SPP1/COL4A1/COL4A2/FLT1/FN1/PGF/PIK3CB/PARVA/PXN/ACTN4/LIMS2/RAC3/PIK3R2/FERMT2/ERBB2/FLNB/AKT3/TGFB1/LAMA5/ITGB1/PDGFB/FBN1/TLN1/LAMB1/FLT4/LAMA4/ACTN1/AKT1/PTK2/LAMC1/ILK/PIK3R3/EGFR/AKT2/TLN2/ITGA3/MTOR/CDH1	2.36812732114366
Human Diseases	Infectious disease: viral	hsa05162	Measles	35/1692	136/9376	1.42608816576276	CCNE1/PIK3CB/IFNAR2/PIK3R2/IRF3/CSNK2B/IL2RB/ADAR/AKT3/CBLB/STAT2/MAPK9/FOS/OAS3/JAK1/AKT1/OAS1/APAF1/CD46/IFNAR1/TYK2/MAP3K7/TBK1/TRAF3/PIK3R3/MAVS/AKT2/CSNK2A2/BAK1/TP53/FCGR2B/FADD/CD209/TRADD/TLR7	2.34868665535038
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	36/1692	142/9376	1.40485465987414	PPARG/CSF1R/TGFB2/PIK3CB/IFNAR2/ITPR2/MAPK3/PLCG2/IL1R1/PIK3R2/AKT3/TGFB1/STAT2/FHL2/MAPK9/FOS/JAK1/GRB2/MAP2K7/AKT1/IFNAR1/MITF/FOSB/TYK2/MAP3K7/MAP3K14/FCGR3A/PIK3R3/AKT2/GAB2/LILRB5/TNFRSF11A/MAPK14/FCGR2B/TAB1/TRAF2	2.28108001142873
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	44/1692	180/9376	1.35455739427371	ITGA5/HLA-G/PIK3CB/IFNAR2/TAPBP/PIK3R2/IRF3/TAP1/TAP2/AKT3/NXF1/SRSF1/STAT2/OAS3/SRSF6/TAPBPL/JAK1/HCFC1/AKT1/OAS1/APAF1/TSC1/IFNAR1/PDIA3/SRSF5/TYK2/MAP3K7/TBK1/SRSF7/TRAF3/POU2F1/PIK3R3/MAVS/HLA-DQA1/AKT2/BAK1/EIF4EBP1/TP53/MTOR/FADD/JAK2/TAB1/TRAF2/TRADD	2.25380043149553
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	23/1692	83/9376	1.5355606824461	ECH1/IDH2/ACSL4/PIPOX/ABCD1/FAR2/ACSL5/PEX6/PRDX1/AGXT/IDH1/ABCD4/FAR1/MLYCD/NOS2/PHYH/PEX26/CRAT/AMACR/PRDX5/AGPS/PEX14/PEX19	2.29965085075098
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	48/1692	201/9376	1.323312515437	HPGD/FLT1/PPARG/CSF1R/ASPSCR1/CEBPB/CEBPA/IL2RB/MYCN/FOXO1/ARNT2/IGFBP3/CD14/RXRB/RXRA/EWSR1/DOT1L/BMP2K/ETV5/ETV4/PTK2/AFF1/IL1R2/MAF/MITF/ATM/SP1/SIX4/BMI1/HDAC1/FUT8/NCOR1/RUNX1/MLLT1/TCF3/BAK1/FUS/TP53/ATF1/ZBTB17/LDB1/MEN1/MLLT3/PTCRA/ETV7/ELANE/LYL1/DEFA3	2.17425084831979
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	32/1692	125/9376	1.41859101654846	PIK3CB/MAPK3/RAC3/PIK3R2/SGPP1/AKT3/ACER2/S1PR2/MAPK9/PPP2R3B/GNAI1/RAF1/ABCC1/AKT1/HRAS/GNA12/CERS5/SPTLC2/PPP2R5E/PRKCE/ROCK2/NRAS/PIK3R3/AKT2/GAB2/PLCB1/MAPK14/TP53/PLD2/PLCB3/TRAF2/TRADD	2.21076565535646
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	7/1692	17/9376	2.28174106522041	MYH10/DAG1/MYH9/TFRC/LAMP2/LAMP1/CD209	2.48200227504295
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	15/1692	49/9376	1.69633810971197	GALNT7/PLOD3/GALNT2/GALNT6/COLGALT1/GALNT3/GALNT1/EOGT/GALNT14/B4GALT2/POFUT2/GALNT12/B4GALT3/POMT1/POMT2	2.29318638854223
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	26/1692	98/9376	1.47015969508371	SCARB1/POMC/CYP11A1/ITPR2/AGTR1/CREB3L2/CREB5/PRKD3/ATF6B/CAMK2G/DAGLB/ATF4/ADCY7/ATP1A1/GNAS/PRKCE/CALM3/ADCY5/PLCB1/ADCY9/ATF1/GNA11/CACNA1C/KCNJ5/PLCB3/CALML4	2.19544918355109
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	14/1692	45/9376	1.72398213816654	ABCA1/TAP1/TAP2/ABCA7/ABCD1/ABCC1/ABCC10/ABCG1/ABCD4/ABCB6/ABCG2/ABCA4/ABCB10/ABCC3	2.28434740932285
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	20/1692	71/9376	1.56094962208238	PIK3CB/MAPK3/PIK3R2/CGA/AKT3/MAPK9/FOS/GRB2/RAF1/SOCS7/AKT1/HRAS/GALT/SOS1/NRAS/PIK3R3/AKT2/TNFRSF11A/MAPK14/JAK2	2.22631690920721
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	11/1692	33/9376	1.84712371946414	SNAP23/SNAP29/STX16/BET1/YKT6/VAMP7/STX5/STX6/GOSR2/BET1L/STX1A	2.28745614807261
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	27/1692	104/9376	1.43862520458265	LPCAT1/DGKZ/LPIN2/CHKB/AGPAT1/GDPD5/CRLS1/GPAT4/PLPP2/LYPLA1/LCAT/PLA2G10/PLPP5/GPAM/LYPLA2/PTDSS2/LPCAT3/DGKH/CDS2/PNPLA6/PLD2/LPCAT4/GPD2/DGKQ/LCLAT1/PLA2G15/PLA2G4B	2.11064737232277
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	27/1692	105/9376	1.42492401215805	PIK3CB/ITPR2/MAPK3/PLCG2/PIK3R2/KSR1/AKT3/CBLB/STAT2/MAPK9/EGR3/PAK1/RAF1/AKT1/NFATC4/HRAS/MRAS/CALM3/PLK3/NRAS/MAP3K14/PIK3R3/AKT2/MAPK14/IL17D/CD209/CALML4	2.0546354258578
Human Diseases	Cancer: specific types	hsa05218	Melanoma	20/1692	73/9376	1.51818387901163	FGFR1/PIK3CB/MAPK3/PIK3R2/AKT3/PDGFB/RAF1/AKT1/RB1/HRAS/MITF/FGF18/NRAS/PIK3R3/EGFR/AKT2/BAK1/E2F3/TP53/CDH1	2.08557569390255
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	8/1692	22/9376	2.01504405759725	AOC1/MAOA/HNMT/ALDH3B2/ALDH1B1/CARNMT1/CNDP2/ALDH3A2	2.2366070532051
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	50/1692	216/9376	1.28272480518343	PPARG/ABCA1/PIK3CB/HSPA2/VAV3/CCL3/MAPK3/TNFSF10/PIK3R2/IRF3/XBP1/AKT3/LYN/CAMK2G/VAV2/CD14/RXRB/ATF4/MAPK9/FOS/RXRA/MAP2K7/AKT1/TICAM2/CASP7/PTK2/APAF1/HRAS/ROCK2/CALM3/MAP3K7/TBK1/ABCG1/NRAS/TRAF3/POU2F1/PIK3R3/AKT2/VLDLR/PLCB1/MAPK14/TP53/CYP2J2/PLCG1/AGER/PLCB3/CALML4/JAK2/TAB1/TRAF2	1.97258257163537
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	17/1692	60/9376	1.57005516154452	PIK3CB/MAPK3/PLCG2/PXN/RAC3/PIK3R2/AKT3/RAF1/AKT1/PTK2/HRAS/NRAS/PIK3R3/AKT2/MAPK14/PLCG1/PLA2G4B	2.0785951377415
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	29/1692	115/9376	1.39738924863809	PIK3CB/ITPR2/KCNJ2/MAPK3/PIK3R2/CREB3L2/CACNA1A/CREB5/GNG12/CHRM5/AKT3/CAMK2G/ATF4/FOS/GNAI1/ADCY7/AKT1/HRAS/ADCY5/NRAS/PIK3R3/AKT2/PLCB1/ADCY9/KCNJ6/GNA11/CACNA1C/PLCB3/JAK2	2.01200117788415
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	18/1692	65/9376	1.53453355155483	SCARB1/POMC/CYP11A1/ITPR2/AGTR1/CREB3L2/CREB5/ATF6B/ATF4/ADCY7/GNAS/SP1/ADCY5/PLCB1/ADCY9/GNA11/CACNA1C/PLCB3	2.02920360227169
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	8/1692	23/9376	1.92743344639737	MGAT5B/B4GALT2/CRPPA/B4GALT3/B4GAT1/POMT1/CHST10/POMT2	2.08960088854944
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	8/1692	23/9376	1.92743344639737	MME/PRCP/AGTR1/CTSA/LNPEP/THOP1/ENPEP/PREP	2.08960088854944
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	47/1692	205/9376	1.27046070460705	CCNE1/HLA-G/PIK3CB/IFNAR2/PLCG2/TAPBP/PIK3R2/IRF3/TAP1/TAP2/NCOR2/AKT3/LYN/PSMC4/STAT2/MAPK9/OAS3/TAPBPL/JAK1/ISG15/MAP2K7/AKT1/OAS1/RB1/APAF1/IFNAR1/PDIA3/TYK2/MAP3K7/TBK1/HDAC1/TRAF3/MAP3K14/PIK3R3/MAVS/HLA-DQA1/AKT2/BAK1/MAPK14/E2F3/RIPK1/TP53/FADD/TAB1/TRAF2/CXCL10/TRADD	1.83723579572021
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	47/1692	205/9376	1.27046070460705	CCNE1/HLA-G/DDB1/PIK3CB/MAPK3/PXN/ACTN4/PIK3R2/IRF3/CREB3L2/CREB5/LYN/ATF6B/HDAC5/IL6ST/MRPS18B/ATF4/EP300/EGR3/ACTN1/JAK1/GRB2/RB1/SRF/HRAS/SCRIB/CHD4/DNAJA3/DLG1/GTF2H4/HDAC1/NRAS/RBL2/TRAF3/HDAC10/SND1/PIK3R3/BAK1/H2BC15/HDAC6/KAT2A/TP53/VAC14/TBP/TRAF2/TRADD/TBPL1	1.83723579572021
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	10/1692	32/9376	1.73167848699764	WIPI1/ATG9A/ATG13/ATG16L1/ATG2B/WIPI2/PIK3C3/ULK2/MTOR/RPTOR	1.9454541491129
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	26/1692	105/9376	1.37214904874479	PLCG2/IL1R1/CSNK2B/LYN/CCL4/CCL4L2/CD14/ERC1/TICAM2/ATM/XIAP/TRIM25/MAP3K7/TRAF3/MAP3K14/CSNK2A2/PPP1R13L/TNFRSF11A/RIPK1/CARD14/PLCG1/TAB1/CCL13/TRAF2/TRADD/PIDD1	1.7994526018123
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	26/1692	105/9376	1.37214904874479	CSNK2B/ATF4/MAPK9/ATG9A/RHOT2/HRAS/MRAS/MITF/PINK1/SP1/TOMM40/SMURF1/SIAH1/TBK1/NRAS/RAB5C/CITED2/MFN2/CSNK2A2/TP53/MFN1/TOMM70/NLRX1/ULK1/CCZ1B/TRAF2	1.7994526018123
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	23/1692	91/9376	1.40056633673655	PIK3CB/INPPL1/VAV3/MAPK3/PLCG2/RAC3/PIK3R2/AKT3/LYN/VAV2/FOS/GRB2/RAF1/AKT1/HRAS/CD22/SOS1/NRAS/BANK1/PIK3R3/AKT2/LILRB5/FCGR2B	1.80175746594316
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	12/1692	41/9376	1.62186472928559	RAD50/POLD4/BRCA2/ATM/POLD1/RAD51C/TOP3B/BARD1/RPA4/XRCC2/BABAM1/MUS81	1.87250433593951
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/1692	20/9376	1.93947990543735	UGDH/GNE/UGP2/GMPPA/NANS/CYB5R2/TGDS	1.97355632732343
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	53/1692	238/9376	1.23400282098655	FGFR1/FLT1/PGF/CSF1R/RASGRF2/PIK3CB/EFNA1/MAPK3/PLCG2/RAC3/PIK3R2/RASA1/RGL2/KSR1/GNG12/AKT3/PDGFB/INSR/MAPK9/RALBP1/FLT4/PAK1/GRB2/RAF1/AKT1/TIAM1/HRAS/PAK2/MRAS/PLA2G10/RASGRF1/NF1/FOXO4/CALM3/FGF18/TBK1/SOS1/NRAS/RAB5C/PIK3R3/EGFR/TEK/AKT2/EFNA4/GAB2/RGL1/PLCG1/PLD2/CALML4/RALGAPA2/PLA2G4B/ANGPT2/FGFR3	1.71583741681833
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	16/1692	59/9376	1.50274472091998	MGLL/PIK3CB/PIK3R2/CGA/AKT3/INSR/PTGER3/GNAI1/ADCY7/AKT1/GNAS/ADCY5/PIK3R3/AKT2/ADCY9/FABP4	1.81772264024269
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/1692	50/9376	1.55158392434988	PYCR1/AOC1/MAOA/SAT1/ALDH18A1/OAT/P4HA2/ALDH1B1/PYCR3/CNDP2/P4HA1/NOS2/GATM/ALDH3A2	1.8350209905396
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/1692	55/9376	1.51128304319794	GM2A/PSAP/HEXB/SGPP1/ACER2/GLB1/HEXA/ARSA/UGCG/PLPP2/CERS5/SPTLC2/ACER3/SMPD4/GBA2	1.78444686133286
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1692	51/9376	1.52116071014694	TJP2/PLCG2/KDELR3/SEC61A1/TJP1/KDELR2/PDIA4/GNAS/KDELR1/ATP6V0A1/ADCY9/PLCG1/ATP6V1C2/ATP6V1E2	1.75115454016824
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	17/1692	65/9376	1.44928168757956	DGKZ/MGLL/AKR1B1/LIPG/LPIN2/AGPAT1/ABHD16A/GPAT4/PLPP2/PLPP5/GPAM/ALDH1B1/PNPLA3/DGKH/DGKQ/LCLAT1/ALDH3A2	1.70556930658381
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	15/1692	56/9376	1.48429584599797	GRK3/GLI3/CSNK1E/BOC/SCUBE2/HHAT/CSNK1G2/CSNK1G3/CSNK1A1/SMURF1/MGRN1/CSNK1G1/CUL1/PTCH1/DHH	1.70564615954094
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	22/1692	89/9376	1.36977714027678	TUBB2A/ITPR2/TUBB/MAPK3/TJP1/PDGFB/TUBA1C/GNAI1/ADCY7/GRB2/RAF1/HRAS/TUBB6/GNAS/ADCY5/SOS1/NRAS/EGFR/PLCB1/ADCY9/GNA11/PLCB3	1.64471055470088
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	24/1692	99/9376	1.34336270506483	IL1RAP/PIK3CB/ITPR2/PLCG2/IL1R1/PIK3R2/CAMK2G/MAPK9/ADCY7/GNAS/PRKCE/CALM3/ADCY5/PIK3R3/TRPV4/F2RL1/PLCB1/MAPK14/ADCY9/CYP2J2/PLCG1/PLCB3/CALML4/PLA2G4B	1.61160675924289
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	15/1692	57/9376	1.45825556799801	FASN/ACSL4/FADS1/ACADVL/ELOVL2/ACSL5/FADS2/CPT1B/CPT1A/CPT2/TECR/ACACA/PPT2/HSD17B8/ACADS	1.62836838519492
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	22/1692	90/9376	1.35455739427371	PIK3CB/MAPK3/PIK3R2/CSNK2B/CD274/AKT3/FOS/JAK1/RAF1/AKT1/TICAM2/HRAS/NRAS/BATF3/PIK3R3/EGFR/AKT2/CSNK2A2/MAPK14/PLCG1/MTOR/JAK2	1.58593579549556
NA	NA	hsa03272	Virion - Hepatitis viruses	13/1692	48/9376	1.50078802206462	CLDN19/SCARB1/HSPG2/CLDN7/DPP4/CD63/LAMP2/LAMP1/EGFR/CHMP1A/CLDN23/CLDN14/CHMP7	1.63219642479891
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1692	154/9376	1.25940253599828	ITPR2/KCNJ2/PRKAG2/MAPK3/CAMK2G/FOS/PPP1R12C/GNAI1/PRKAG1/ADCY7/EEF2K/EEF2/RAF1/PPP1R12B/NFATC4/HRAS/GNAS/RCAN1/ROCK2/CALM3/ADCY5/NRAS/EGFR/CAMKK2/PLCB1/ADCY9/KCNJ6/CACNA1C/KCNJ5/CACNB3/PLCB3/CALML4/TRPM2/PRKAB2/PLA2G4B	1.52304999134831
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	12/1692	44/9376	1.51128304319794	TAF5L/CDK7/TAF9/TAF4B/TAF1/TAF3/TAF4/GTF2H4/TAF6/TBP/ERCC3/TBPL1	1.59511684786804
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/1692	72/9376	1.38534278959811	IRF3/ADAR/MAPK9/ISG15/OTUD5/TRIM25/MAP3K7/TBK1/TRAF3/MAVS/MAPK14/RIPK1/NLRX1/FADD/DHX58/TRAF2/CXCL10/TRADD	1.54017749723311
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	49/1692	226/9376	1.20144772903199	POMC/PIK3CB/VAV3/MAPK3/RAC3/PIK3R2/CREB3L2/CREB5/CGA/GLI3/AKT3/CAMK2G/VAV2/HCAR1/HCAR2/MAPK9/FOS/EP300/PTGER3/SLC9A1/GNAI1/ADCY7/PDE10A/ATP1A1/PAK1/RAF1/AKT1/TIAM1/GNAS/ROCK2/CALM3/ADCY5/RAPGEF3/PPARA/PIK3R3/AKT2/AMH/SST/PTCH1/ADCY9/GRIN2D/PLD2/SSTR2/CACNA1C/GIPR/CALML4/CRH/EDN3/GRIN3B	1.43846131858147
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	16/1692	63/9376	1.40733235768697	TCF7L2/AXIN2/GLI3/TCF7L1/FZD8/WNT7A/TCF7/DVL3/FZD5/AXIN1/BAK1/PTCH1/TP53/FZD9/FZD10/FZD2	1.52218179538312
Organismal Systems	Immune system	hsa04611	Platelet activation	29/1692	126/9376	1.27539494915381	PIK3CB/ITPR2/APBB1IP/MAPK3/PLCG2/PIK3R2/VASP/AKT3/LYN/ITGB1/SNAP23/TLN1/GNAI1/ADCY7/AKT1/GNAS/ROCK2/PRKCI/ADCY5/PIK3R3/AKT2/TLN2/PLCB1/MAPK14/ADCY9/PLCB3/P2RY1/PLA2G4B/GP1BB	1.46036870117196
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	14/1692	54/9376	1.43665178180545	CENPX/BRCA2/RAD51C/FANCE/FAN1/TOP3B/RPA4/EME2/REV1/RMI1/FAAP100/MUS81/POLI/ATR	1.50997482555425
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	19/1692	78/9376	1.34982117960841	TOB2/LSM2/CNOT6/DCP2/PFKL/EXOSC4/CNOT3/PARN/CNOT1/EDC4/PABPC1L/TENT4A/PAN2/PABPC3/CNOT8/PNPT1/EXOSC10/DCP1B/CNOT10	1.45576331082401
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	32/1692	142/9376	1.2487596976659	PIK3CB/HMOX1/IL1R1/RAC3/PIK3R2/ARHGEF2/AKT3/BMPR2/GSTA3/PDGFB/MAPK9/FOS/MAP2K7/AKT1/PTK2/SDC4/IL1R2/CTSL/DUSP1/MMP2/CALM3/MAP3K7/GPC1/BMPR1B/ACVR1/PIK3R3/TRPV4/AKT2/MAPK14/TP53/CALML4/ACVR2B	1.40159131222831
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/1692	69/9376	1.3652653578648	CREB3L2/CREB5/ATF6B/CAMK2G/MAOA/ATF4/FOS/GNAS/FOSB/CALM3/ADCY5/HDAC1/GRIN2D/CACNA1C/STX1A/CALML4/GRIN3B	1.42896079324084
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	24/1692	103/9376	1.29119327962542	DDX39B/SYMPK/NXF1/CPSF1/PABPN1/PPP2R3B/ACIN1/PCF11/PAPOLA/UPF2/DAZAP1/PPP2R5E/NUDT21/UPF1/SMG7/MSI2/PABPC1L/FUS/CPSF2/PABPC3/SMG5/RNGTT/CPSF4/NCBP1	1.39438264807428
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	24/1692	103/9376	1.29119327962542	TGFB2/PIK3CB/CCL3/MAPK3/PIK3R2/C1QA/AKT3/TGFB1/SERPINE1/C1QB/MAPK9/FOS/GNAI1/AKT1/GNAS/PIK3R3/AKT2/NOS2/PLCB1/MAPK14/GNAL/GNA11/FADD/PLCB3	1.39438264807428
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	25/1692	108/9376	1.28272480518343	DDX39B/NXF1/NUP50/ACIN1/XPOT/NUP58/TNPO3/UPF2/XPO7/POM121/NUP93/NUP155/RANGAP1/UPF1/NUP62/IPO9/NUP133/THOC6/IPO4/AAAS/NUP160/NUP107/NUP43/NCBP1/XPO4	1.38667574166252
Organismal Systems	Nervous system	hsa04730	Long-term depression	15/1692	60/9376	1.38534278959811	ITPR2/MAPK3/CACNA1A/LYN/GNAI1/RAF1/HRAS/GNA12/GNAS/NRAS/PLCB1/GNA11/PLCB3/CRH/PLA2G4B	1.40507744312358
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	97/1692	480/9376	1.11981875492514	TUBB2A/HIP1/ITPR2/TUBB/GPX3/MAPK3/AXIN2/CSNK2B/NDUFA6/XBP1/CHRM5/DNAH11/CSNK1E/CAMK2G/NDUFS1/PSMC4/WIPI1/PSMA2/NDUFS3/GPX8/ATF4/MAPK9/NDUFA7/MAP3K10/TUBA1C/PSMA6/RAF1/FZD8/MAP2K7/ATXN2/CASP7/APAF1/HRAS/ATG13/PINK1/SMCR8/TUBB6/SDHA/CSNK1A1/TOMM40/FRAT2/RAB1A/CALM3/WNT7A/TBK1/UBE2L6/FRAT1/DVL3/NRAS/HTT/DNAH14/GPR37/FZD5/MT-ND2/ATG2B/NDUFA13/MFN2/WIPI2/DCTN1/NOS2/AXIN1/CSNK2A2/BAK1/PLCB1/FUS/MAPK14/MT-ND5/SLC25A4/PIK3C3/MFN1/UBA7/ULK2/FZD9/FZD10/GRIN2D/PLCG1/MTOR/COX4I2/LRP6/CACNA1C/MAPT/AGER/ALS2/ATXN1L/FADD/VAPB/ULK1/PSEN2/PLCB3/STX1A/CALML4/PSMA8/DNAH8/TRAF2/FZD2/NOX4/MT-ND1	1.26456213468775
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	18/1692	75/9376	1.32992907801418	ITPR2/GPX3/CREB3L2/CREB5/CANX/CGA/ATF6B/PDIA4/GPX8/ATF4/TTR/ADCY7/ATP1A1/GNAS/ADCY5/PLCB1/ADCY9/PLCB3	1.34610377555933
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1692	42/9376	1.45131149386469	HMOX1/ACSL4/SLC39A14/TFRC/SAT1/ACSL5/NCOA4/SLC11A2/LPCAT3/GPX4/TP53	1.37549583765428
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	34/1692	155/9376	1.21552657667963	ITGA5/SCARB1/TUBB2A/HLA-G/MRC2/TUBB/TAP1/TAP2/SEC61A1/CANX/ITGB1/CD14/COLEC12/TFRC/TUBA1C/LAMP2/MRC1/HGS/CTSL/DYNC1LI2/TUBB6/LAMP1/RILP/PIKFYVE/RAB5C/FCGR3A/ATP6V0A1/HLA-DQA1/PIK3C3/FCGR2B/MARCO/CD209/ATP6V1C2/ATP6V1E2	1.26960846208408
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/1692	47/9376	1.4148181681002	PIK3CB/MAPK3/PIK3R2/CACNA1A/INSR/MAPK9/PRKCE/HK1/PIK3R3/MTOR/CACNA1C/MAFA	1.33776950293248
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	18/1692	76/9376	1.31243001119821	ANGPTL4/PPARG/ACSL4/SLC27A1/PLTP/PLIN2/RXRB/RXRA/ACSL5/FABP7/FADS2/CPT1B/PPARD/CPT1A/CPT2/PPARA/ILK/FABP4	1.28324684656746
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	18/1692	76/9376	1.31243001119821	CA2/ITPR2/KCNJ2/CAMK2G/SLC9A1/GNAI1/ADCY7/ATP1A1/GNAS/CALM3/ADCY5/SLC4A2/PLCB1/SST/ADCY9/SSTR2/PLCB3/CALML4	1.28324684656746
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	13/1692	52/9376	1.38534278959811	ANGPTL4/SCARB1/LRP1/ABCA1/MYLIP/LIPG/PLTP/SOAT1/LCAT/APOE/STARD3NL/STARD3/VAPB	1.30749463608979
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1692	67/9376	1.323312515437	ITPR2/MAPK3/CAMK2G/ATF4/EP300/RAF1/HRAS/RPS6KA1/CALM3/NRAS/RAPGEF3/PLCB1/GRIN2D/CACNA1C/PLCB3/CALML4	1.24623671620414
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	27/1692	122/9376	1.22636902685734	PIK3CB/VAV3/MAPK3/PIK3R2/AKT3/CBLB/VAV2/MAPK9/FOS/PPP2R3B/PAK1/GRB2/RAF1/MAP2K7/AKT1/HRAS/PAK2/PPP2R5E/DLG1/MAP3K7/SOS1/NRAS/MAP3K14/PIK3R3/AKT2/MAPK14/PLCG1	1.18093042319463
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	25/1692	112/9376	1.23691320499831	TGFB2/BIRC7/IL10RB/MAPK3/IL10RA/AKT3/TGFB1/LAMA5/ITGB1/LAMB1/MAPK9/LAMA4/GNAI1/JAK1/AKT1/XIAP/LAMC1/TYK2/MAP3K7/HLA-DQA1/AKT2/NOS2/MAPK14/JAK2/TAB1	1.18356236116725
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	29/1692	133/9376	1.20826889919835	ITPR2/CREB3L2/CACNA1A/CREB5/GNG12/AKT3/ATF6B/CAMK2G/MAOA/ATF4/MAPK9/FOS/PPP2R3B/GNAI1/AKT1/PPP2R5E/GNAS/CALM3/ADCY5/AKT2/GSK3A/PLCB1/MAPK14/GNAL/KCNJ6/CACNA1C/KCNJ5/PLCB3/CALML4	1.13510465580111
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/1692	12/9376	1.84712371946414	NECTIN4/CD46/FCGR2B/CD209	1.37784036023464
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	38/1692	181/9376	1.16338179015974	MRC2/TGFB2/IL10RB/CEBPB/MAPK3/IL10RA/KSR1/AKT3/CAMK2G/TGFB1/CD14/MAPK9/EP300/LAMP2/JAK1/RAF1/AKT1/APAF1/MRC1/CALM3/PLK3/LAMP1/RAB5C/NFYA/FCGR3A/ATP6V0A1/HLA-DQA1/AKT2/NOS2/MAPK14/PIK3C3/NFYB/FCGR2B/FADD/CD209/CALML4/JAK2/TRADD	1.04149984674914
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	39/1692	187/9376	1.15568703303372	CTSB/IFNAR2/ITPR2/MAPK3/GSDMD/IRF3/PKN1/STAT2/MAPK9/OAS3/RNF31/JAK1/ANTXR2/OAS1/IFNAR1/XIAP/P2RX7/ATG16L1/RBCK1/TP53BP1/TYK2/MAP3K7/TBK1/TRPM7/TRAF3/MAVS/MFN2/PLCB1/MAPK14/RIPK1/MFN1/NLRX1/FADD/PLCB3/TRPM2/NLRP7/TAB1/TRAF2/DEFA3	1.00909315267472
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/1692	31/9376	1.43003126668192	GCSH/SHMT1/GLDC/HYI/AGXT/AMT/PCCA/MCEE	1.1253389915979
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	17/1692	75/9376	1.25604412923562	PIK3CB/MAPK3/PIK3R2/ERBB2/AKT3/GSTA3/AKT1/APAF1/ATM/XIAP/PIK3R3/TOP2B/AKT2/BAK1/TP53/FADD/ATP7B	1.04465472139757
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	48/1692	235/9376	1.13185453448016	FGFR1/PPARG/MGLL/SMARCB1/PRKAG2/ACSL4/CREB3L2/NDUFA6/CREB5/NDUFS1/NDUFS3/SMARCA4/NDUFA7/PRKAG1/ADCY7/ACSL5/GRB2/TSC1/HRAS/KDM1A/RPS6KA1/CPT1B/SMARCD2/GNAS/KDM3A/SDHA/SMARCC1/CPT1A/ADCY5/SMARCC2/CPT2/SOS1/NRAS/MT-ND2/COX19/NDUFA13/KDM3B/FRS2/MAPK14/MT-ND5/ADCY9/MTOR/COX4I2/SLC25A20/PRKAB2/KLB/MT-ND1/RPTOR	0.960559531719544
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	33/1692	157/9376	1.16474680399331	PPARG/PIK3CB/PRKAG2/PIK3R2/CEBPA/NDUFA6/XBP1/AKT3/NDUFS1/TGFB1/SREBF1/INSR/MLXIP/ITCH/NDUFS3/ATF4/MAPK9/FOS/NDUFA7/RXRA/PRKAG1/AKT1/CASP7/SDHA/PPARA/PIK3R3/NDUFA13/AKT2/GSK3A/MAPK14/COX4I2/PRKAB2/TRAF2	0.97682565315698
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1692	41/9376	1.35155394107133	PIPOX/GCSH/SHMT1/GLDC/MAOA/PHGDH/AGXT/AMT/GATM/PSAT1	1.05856828337721
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	36/1692	173/9376	1.15311769770016	PIK3CB/IFNAR2/MAPK3/TNFSF10/PIK3R2/IRF3/ADAR/AKT3/NXF1/STAT2/PABPN1/EP300/OAS3/JAK1/RAF1/AKT1/OAS1/APAF1/IFNAR1/TRIM25/TYK2/TBK1/TRAF3/PIK3R3/MAVS/HLA-DQA1/AKT2/BAK1/SLC25A4/NLRX1/FADD/JAK2/CXCL10/CPSF4/TRADD/TLR7	0.953840745486208
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1692	13/9376	1.70503727950536	RAD50/POLM/DCLRE1C/XRCC4	1.1936263162043
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	35/1692	168/9376	1.15445232466509	CSF2RB/PIK3CB/IFNAR2/IL10RB/CSF2RA/IL10RA/PIK3R2/IL2RB/IL13RA1/AKT3/STAT2/IL6ST/PDGFB/LIFR/EPOR/EP300/JAK1/GRB2/RAF1/SOCS7/AKT1/IL11/HRAS/IFNAR1/STAT6/TYK2/SOS1/PIK3R3/EGFR/AKT2/CSH1/MTOR/STAM2/IL11RA/JAK2	0.947891380877578
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16/1692	71/9376	1.2487596976659	F11R/PLCG2/JAM2/TJP1/LYN/ADAM10/MAPK9/PAK1/GIT1/MAP3K14/EGFR/ATP6V0A1/MAPK14/PLCG1/ATP6V1C2/ATP6V1E2	0.987286379099369
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/1692	32/9376	1.38534278959811	BIRC7/MAPK9/CASP7/APAF1/XIAP/BIRC6/BAK1/FADD	1.0245848992097
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1692	37/9376	1.34790109258194	GFPT1/RIMKLB/AGXT/ADSL/GPT2/GFPT2/GPT/IL4I1/PPAT	0.994943929176322
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/1692	18/9376	1.53926976622012	FASN/ACSL4/ACSL5/ACACA/HSD17B8	1.0745903696037
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1692	18/9376	1.53926976622012	CD320/HCFC1/PRDX1/ABCD4/ZNF76	1.0745903696037
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	17/1692	78/9376	1.20773473964963	ITGA5/SERPING1/MAPK3/IRF3/C1QA/ITGB1/C1QB/CD14/MAPK9/FOS/GNAI1/TICAM2/CASP7/CALM3/NOS2/MAPK14/CALML4	0.864477710309114
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1692	33/9376	1.34336270506483	IDH2/ACY1/AGXT/IDH1/GPT2/GPT/AADAT/DBT	0.927169329193404
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	23/1692	109/9376	1.16928015268831	IL1RAP/MAPK3/EBI3/IL1R1/IL2RB/GATA3/TGFB1/IL6ST/SMAD3/RXRB/MAPK9/FOS/RXRA/JAK1/SMAD4/STAT6/TYK2/HLA-DQA1/RUNX1/MAPK14/PLCG1/MTOR/JAK2	0.834145572538705
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	11/1692	48/9376	1.2698975571316	PIK3CB/PIK3R2/AKT3/ATP1A1/AKT1/HK1/PIK3R3/AKT2/SLC37A4/PLCB1/PLCB3	0.879665264348742
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1692	19/9376	1.45825556799801	GCSH/GLDC/AMT/LIPT2/DBT	0.938227969869775
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	41/1692	205/9376	1.10827423167849	TGFB2/PIK3CB/PDK3/GFPT1/AGTR1/PIK3R2/NDUFA6/TBC1D4/AKT3/CAMK2G/NDUFS1/TGFB1/INSR/SMAD3/NDUFS3/MAPK9/NDUFA7/AKT1/GYS1/CPT1B/SP1/SDHA/MMP2/CPT2/PPARA/PIK3R3/MT-ND2/NDUFA13/AKT2/GFPT2/PTPA/PDK4/PLCB1/MAPK14/MT-ND5/SLC25A4/MTOR/COX4I2/AGER/PLCB3/MT-ND1	0.73550534626773
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1692	49/9376	1.24398128045544	CREB3L2/CREB5/ATF6B/MAOA/ATF4/GNAI1/GNAS/FOSB/ADCY5/GRIN2D/GRIN3B	0.803481158931482
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1692	34/9376	1.30385203726881	PRKAG2/CSNK1E/NFIL3/PRKAG1/SKP1/CUL1/CRY1/PRKAB2	0.832863479637617
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/1692	44/9376	1.25940253599828	CREB3L2/CREB5/NSF/DYNC1LI2/DYNLL2/GNAS/RAB5C/DCTN1/ADCY9/AQP3	0.809292154424853
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/1692	85/9376	1.17346683354193	IMPDH2/TYMP/ENTPD4/GMPR2/UCK2/AMPD2/AK6/ADA/CANT1/AMPD3/NME2/AK1/ADSL/GDA/NME6/CMPK2/CTPS2/ENTPD6	0.753853270381332
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	24/1692	117/9376	1.13669151967024	MBD3/SMARCB1/MORF4L2/MBD2/SMARCA4/SRCAP/INO80D/PBRM1/EP400/BAZ2A/CHD4/SMARCD2/TFPT/SMARCC1/SMARCC2/INO80B/HDAC1/SMARCA1/MTA3/BICRA/NFRKB/TRRAP/KAT5/RBBP7	0.698143341138359
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	70/1692	362/9376	1.07153585935765	FGFR1/ITGA5/SPP1/COL4A1/COL4A2/FLT1/FN1/PGF/CSF1R/CCNE1/PIK3CB/IFNAR2/EFNA1/MAPK3/PIK3R2/CREB3L2/CREB5/ERBB3/IL2RB/ERBB2/GNG12/AKT3/ATF6B/PKN1/LAMA5/ITGB1/PDGFB/INSR/LAMB1/EPOR/ATF4/PPP2R3B/FLT4/LAMA4/RXRA/SGK1/JAK1/PHLPP1/GRB2/RAF1/AKT1/PTK2/TSC1/HRAS/IFNAR1/GYS1/PPP2R5E/LAMC1/LPAR2/STK11/FGF18/SOS1/NRAS/RBL2/PIK3R3/EGFR/LPAR6/TEK/AKT2/CSH1/EFNA4/ITGA3/EIF4EBP1/TP53/MTOR/TCL1B/JAK2/ANGPT2/FGFR3/RPTOR	0.65134554423146
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1692	30/9376	1.2929866036249	SHMT1/FOLR2/FOLR1/ABCC1/ABCG2/ABCC3/ATIC	0.754201934140759
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	27/1692	134/9376	1.11654493489997	ADM/ITPR2/MAPK3/AGTR1/MYH10/MYH9/CALD1/PPP1R12C/ADCY7/RAF1/PPP1R12B/GNA12/PLA2G10/GNAS/PRKCE/ROCK2/CALM3/ADCY5/ACTG2/PLCB1/ADCY9/GNA11/CACNA1C/PLCB3/CALML4/EDN3/PLA2G4B	0.637609765733763
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/1692	51/9376	1.19519770082974	LPCAT1/PLA2G7/GDPD3/PLPP2/PLA2G10/GDPD1/PLD2/LPCAT4/PLA2G4B/AGPS/PAFAH2	0.655884707697988
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1692	36/9376	1.2314158129761	GAA/UGP2/GYS1/HK1/PGM1/AGL/PYGB/GBE1	0.652774203198946
NA	NA	hsa04981	Folate transport and metabolism	7/1692	31/9376	1.25127735834668	SHMT1/FOLR2/FOLR1/ABCC1/SLCO2B1/ABCG2/ABCC3	0.657561975051444
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1692	16/9376	1.38534278959811	MIF/MAOA/ALDH3B2/IL4I1	0.723871442263668
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1692	16/9376	1.38534278959811	HEXB/HEXA/ST8SIA1/NAGA	0.723871442263668
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	59/1692	308/9376	1.06149642319855	PPARG/TUBB2A/HIP1/TUBB/GPX3/CREB3L2/AP2A2/NDUFA6/SLC1A3/CREB5/DNAH11/NDUFS1/CLTB/PSMC4/WIPI1/PSMA2/NDUFS3/GPX8/MAPK9/EP300/NDUFA7/MAP3K10/TUBA1C/PSMA6/RCOR1/MAP2K7/TAF4B/APAF1/ATG13/TUBB6/SP1/SDHA/TAF4/HDAC1/HTT/DNAH14/MT-ND2/ATG2B/NDUFA13/WIPI2/DCTN1/TFAM/PLCB1/MT-ND5/SLC25A4/PIK3C3/TP53/ULK2/MTOR/COX4I2/ULK1/PLCB3/STX1A/TBP/PSMA8/DNAH8/TRAF2/MT-ND1/TBPL1	0.514945892984982
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	19/1692	94/9376	1.12006438307932	CEBPB/MAPK3/SRSF1/MAPK9/FOS/MAPK6/FOSB/MAP3K7/TBK1/TRAF3/ELAVL1/MAPK14/IL17D/IL17B/MAPK15/FADD/TRAF2/CXCL10/TRADD	0.548971094729361
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	11/1692	52/9376	1.17221312965994	SCARB1/CYP11A1/CGA/INSR/ADCY7/GNAS/ADCY5/ADCY9/CYP2J2/PLA2G4B/CYP19A1	0.584331014807472
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	31/1692	158/9376	1.08723105006434	CCNE1/TGFB2/CDK7/CDKN1C/TGFB1/SMAD3/EP300/SKP1/RB1/SMAD4/E2F4/PPP2R5E/ATM/PDS5B/PDS5A/MCM4/HDAC1/RBL2/CDC14A/CUL1/MAU2/E2F3/TP53/ANAPC13/ZBTB17/DDX11/TFDP2/ORC2/ATR/TTK/DBF4B	0.518887766200377
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	23/1692	116/9376	1.09872014347436	GRK3/ITPR2/MAPK3/CACNA1A/SLC1A3/GNG12/SLC17A8/HOMER1/GNAI1/ADCY7/SHANK2/GNAS/ADCY5/SLC1A6/PLCB1/ADCY9/GRIK2/GRIN2D/PLD2/CACNA1C/PLCB3/PLA2G4B/GRIN3B	0.502020461486189
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	16/1692	79/9376	1.12230301942125	SLC6A2/DNM2/CACNA1A/AP2A2/SLC1A3/SLC17A8/CLTB/SLC6A4/NSF/SLC6A11/SLC1A6/ATP6V0A1/SYT1/STX1A/ATP6V1C2/ATP6V1E2	0.512237593700018
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	30/1692	154/9376	1.07948788799853	TPM1/MAPK3/AGTR1/CREB3L2/CREB5/AKT3/ATF6B/CAMK2G/ATF4/PPP2R3B/SLC9A1/GNAI1/ADCY7/ATP1A1/AKT1/PPP2R5E/GNAS/CALM3/ADCY5/RAPGEF3/AKT2/RPS6KA5/PLCB1/MAPK14/ADCY9/CACNA1C/CACNB3/PLCB3/CALML4/MYL2	0.466703329104128
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1692	32/9376	1.21217494089835	LDHA/ACACA/MLYCD/PCCA/MCEE/ACADS/DBT	0.564150274258102
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	29/1692	149/9376	1.07852190331128	MGLL/ITPR2/MAPK3/CACNA1A/NDUFA6/GNG12/SLC17A8/NDUFS1/DAGLB/NDUFS3/GABRE/MAPK9/NDUFA7/GNAI1/ADCY7/ADCY5/MT-ND2/NDUFA13/PLCB1/MAPK14/MT-ND5/ADCY9/KCNJ6/FAAH/CACNA1C/KCNJ5/PLCB3/NAPEPLD/MT-ND1	0.453362747289471
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	51/1692	268/9376	1.05451466073886	SLC39A1/TUBB2A/ITPR2/SLC39A7/TUBB/NDUFA6/XBP1/CAMK2G/NDUFS1/PSMC4/PSMA2/MAOA/NDUFS3/SLC39A14/ATF4/MAPK9/SLC39A4/NDUFA7/TUBA1C/PSMA6/GNAI1/APAF1/PINK1/TUBB6/GNAS/DUSP1/SDHA/SLC39A11/CALM3/ADCY5/UBE2L6/SLC39A6/SLC11A2/GPR37/MT-ND2/NDUFA13/MFN2/SLC39A9/MT-ND5/SLC25A4/TP53/SLC39A13/MFN1/UBA7/GNAL/PLCG1/COX4I2/MAPT/CALML4/PSMA8/MT-ND1	0.42487515808847
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	32/1692	166/9376	1.06821612691902	ITPR2/MAPK3/AGTR1/CREB3L2/EDNRB/CREB5/VASP/AKT3/ATF6B/INSR/ATF4/GNAI1/ADCY7/ATP1A1/RAF1/AKT1/NFATC4/SRF/GNA12/PRKCE/ROCK2/CALM3/ADCY5/AKT2/PLCB1/SLC25A4/ADCY9/GNA11/CACNA1C/PLCB3/CALML4/MEF2B	0.416105471379454
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/1692	43/9376	1.15982187036121	ACSL4/ACADVL/ACSL5/CPT1B/CPT1A/CPT2/ALDH1B1/ALDH3A2/ACADS	0.492892197312762
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	22/1692	115/9376	1.06008839551855	ITPR2/MAPK3/CACNA1A/GNG12/MAOA/GNAI1/SLC6A4/RAF1/HRAS/GNAS/DUSP1/ADCY5/NRAS/RAPGEF3/PLCB1/KCNN2/CYP2J2/KCNJ6/CACNA1C/KCNJ5/PLCB3/PLA2G4B	0.304230481762732
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1692	35/9376	1.10827423167849	AKR1B1/PFKFB4/PFKL/GMPPA/PMM2/HK1/TIGAR	0.301130389730256
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	43/1692	233/9376	1.022656479875	ITGA5/COL4A1/FBLN1/COL4A2/TPM1/FN1/HSPG2/COL27A1/SYNE1/BGN/FMNL2/INF2/MYH10/PKP2/DAG1/TNNI2/MYH9/FHL2/ITGB1/FBN1/SYNE3/TLN1/SYNE2/MYOZ1/CSRP1/CSRP2/PDLIM3/ATP1A1/AMPD2/SUN2/SDC4/COL11A1/PDLIM5/AMPD3/TNNT3/ACTG2/DAAM2/TLN2/ITGA3/DIAPH2/DSP/LMNB2/MYL2	0.16433049928064
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1692	30/9376	1.10827423167849	B3GALT4/MPPE1/GPAA1/PIGN/DPM2/PIGW	0.278717982116569
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/1692	63/9376	1.05549926826523	DDB1/CDK7/POLD4/ERCC5/POLD1/GTF2H4/CUL4B/RPA4/UVSSA/LIG1/ERCC3/POLE	0.207398146049897
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1692	14/9376	1.18743667679838	B4GALT2/FUT8/B4GALT3	0.329326299830846
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1692	69/9376	1.04402645013191	CTSB/ITPR2/KCNJ2/AGTR1/GNAI1/GNAS/CALM3/ADCY5/PLCB1/CACNA1C/PLCB3/CALML4/EDN3	0.17223662126578
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1692	36/9376	1.07748883635408	GALNT7/GALNT2/GALNT6/GALNT3/GALNT1/GALNT14/GALNT12	0.218579330242553
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	7/1692	36/9376	1.07748883635408	POLD4/MCM4/POLD1/RPA4/DNA2/LIG1/POLE	0.218579330242553
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/1692	97/9376	1.02829567887695	MAPK3/GNG12/CAMK2G/FOS/GNAI1/ADCY7/GNAS/CALM3/ADCY5/RPS6KA5/PLCB1/ADCY9/KCNJ6/GRIN2D/CACNA1C/KCNJ5/PLCB3/CALML4	0.131446049209707
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	16/1692	86/9376	1.03095277365441	CREB3L2/CREB5/ATF6B/CAMK2G/ATF4/ADCY7/ATP1A1/GNAS/ADCY5/PLCB1/ADCY9/KCNN2/GNA11/CACNA1C/PLCB3/STX1A	0.135310992622567
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/1692	42/9376	1.05549926826523	AOC1/MAOA/KYAT1/ALDH1B1/AADAT/IL4I1/ALDH3A2/ALDH8A1	0.169149276119621
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1692	31/9376	1.07252345001144	ALDH3B2/ALDH1B1/CNDP2/MLYCD/ALDH3A2/ACADS	0.189784958504984
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1692	48/9376	1.03900709219858	HIBADH/ALDH1B1/PCCA/IL4I1/ALDH3A2/MCEE/ACADS/AUH/DBT	0.127134103898578
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1692	37/9376	1.04836751645262	HBA2/HBA1/LAMA4/F2RL1/PLCB1/THOP1/PLCB3	0.138323701448389
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/1692	93/9376	1.01293881389969	MAPK3/IL2RB/GATA3/MAPK9/FOS/MAML2/JAK1/MAML1/MAF/NOTCH3/STAT6/TYK2/MAML3/HLA-DQA1/MAPK14/PLCG1/JAK2	0.0588415229774719
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	43/1692	238/9376	1.00117210004569	RPS4Y1/PIK3CB/IFNAR2/F13A1/MAPK3/PLCG2/AGTR1/PIK3R2/IRF3/C1QA/ADAR/RPS17/RPS9/STAT2/IL6ST/C1QB/MAPK9/FOS/OAS3/JAK1/ISG15/OAS1/IFNAR1/C3AR1/NRP1/RPL7A/TYK2/MAP3K7/TBK1/TRAF3/RPL17/RPS18/PIK3R3/MAVS/EGFR/RPS10/MAPK14/RPS25/RPL36A/PLCG1/CXCL10/TLR7/C9	0.00859448234928999
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	39/1692	217/9376	0.995914632153479	PIK3CB/MAPK3/PIK3R2/CREB3L2/CACNA1A/CREB5/AKT3/ATF6B/GSTA3/KLF5/RXRB/ATF4/FOS/RXRA/ARNT/GNAI1/ADCY7/GRB2/RAF1/AKT1/RB1/HRAS/RPS6KA1/XIAP/KLF4/GNAS/FGF18/ADCY5/SOS1/NRAS/PPARA/PIK3R3/EGFR/AKT2/EIF4EBP1/ADCY9/MTOR/CACNA1C/JAK2	-0.028571243557742
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1692	38/9376	1.02077889759861	PIK3CB/MAPK3/PIK3R2/INSR/SGK1/ATP1A1/PIK3R3	0.0602253740189577
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	66/1692	368/9376	0.993832870798643	TUBB2A/TUBB/GPX3/NDUFA6/XBP1/DNAH11/NXF1/NDUFS1/PSMC4/WIPI1/PSMA2/NDUFS3/GPX8/ATF4/NUP50/NDUFA7/TUBA1C/PSMA6/NUP58/ATXN2/APAF1/ATG13/SETX/PINK1/SMCR8/TUBB6/SDHA/TOMM40/RAB1A/POM121/NUP93/TBK1/SRSF7/NUP155/DNAH14/NUP62/MT-ND2/ATG2B/NDUFA13/UBQLN2/WIPI2/DCTN1/NOS2/UBQLN4/HDAC6/FUS/MAPK14/MT-ND5/PIK3C3/TP53/ULK2/NUP133/GRIN2D/MTOR/COX4I2/ALS2/NUP160/NUP107/VAPB/ULK1/PSMA8/DNAH8/NUP43/TRAF2/NCBP1/MT-ND1	-0.0566350002848197
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	8/1692	44/9376	1.00752202879862	POLD4/POLG2/POLG/LIG3/POLD1/PARG/LIG1/POLE	0.0234674609816653
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1692	27/9376	1.02617984414675	FADS1/ELOVL2/FADS2/ACOT7/TECR	0.0639231986418708
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	45/1692	254/9376	0.981738984754565	FGFR1/FLT1/P2RX4/ITPR2/PLCG2/AGTR1/CACNA1A/EDNRB/PTK2B/ERBB3/ERBB2/CHRM5/CAMK2G/PDGFB/PHKA2/FLT4/PTGER3/STIM2/ADCY7/NFATC4/GNAS/P2RX7/CALM3/FGF18/PHKB/EGFR/NOS2/PLCD3/PLCB1/SLC25A4/ADCY9/GNAL/MST1/GNA11/GRIN2D/PLCG1/TPCN1/CACNA1C/TACR3/CASQ1/PLCB3/CALML4/P2RX6/GRIN3B/FGFR3	-0.13844870021774
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	27/1692	154/9376	0.971539099198674	QPRT/DHRS3/NAPRT/PDXK/UGDH/SHMT1/RDH13/UGP2/RFK/CPOX/AK6/GMPPA/NMNAT2/PMM2/GUSB/NME2/AK1/ADSL/ALDH1B1/LIPT2/EARS2/NMNAT3/ALDH3A2/PSAT1/NME6/CMPK2/CTPS2	-0.167104668242382
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/1692	75/9376	0.960504334121355	PYCR1/IDH2/SHMT1/PHGDH/PFKL/ALDH18A1/ACY1/IDH1/PYCR3/GPT2/GPT/PSAT1/RPIA	-0.161141495249435
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	13/1692	75/9376	0.960504334121355	CCNE1/SESN2/CCNG2/IGFBP3/SERPINE1/SHISA5/APAF1/ATM/SIAH1/PPP1R13L/TP53/ATR/PIDD1	-0.161141495249435
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1692	17/9376	0.977889027951606	AMACR/CH25H/CYP39A1	-0.0428163569200204
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1692	23/9376	0.963716723198684	ACY1/GPT2/NOS2/GPT	-0.0817498740616151
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1692	23/9376	0.963716723198684	POLD4/POLD1/RPA4/LIG1	-0.0817498740616151
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	20/1692	116/9376	0.955408820412489	IDH2/GCSH/SHMT1/GLDC/PHGDH/PFKL/ADPGK/AGXT/SDHA/H6PD/HK1/AMT/IDH1/GPT2/GPT/PCCA/PSAT1/MCEE/ACADS/RPIA	-0.226759035865356
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/1692	82/9376	0.946087758749928	LGMN/HLA-G/CTSB/HSPA2/TAPBP/TAP1/TAP2/CANX/TAPBPL/PDIA3/CTSL/NFYA/HLA-DQA1/NFYB	-0.230083310956791
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1692	53/9376	0.940987555198715	DNM2/AP2A2/CLTB/ATP1A1/GNAS/PTH1R/PLCB1/ADCY9/PLCB3	-0.202160284157233
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	22/1692	128/9376	0.9524231678487	IMPDH2/ENTPD4/GMPR2/ADCY7/PDE10A/AMPD2/AK6/ADA/CANT1/ADCY5/AMPD3/NME2/AK1/PGM1/ADSL/GDA/ADCY9/PRUNE1/NME6/ATIC/PPAT/ENTPD6	-0.254313102095849
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1692	59/9376	0.939215450574989	IDH2/GPX3/GSTA3/GPX8/TXNDC12/PRDX6/HPGDS/IDH1/GPX4/GGT7	-0.219772475113426
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1692	36/9376	0.923561859732072	AKR1B1/UGDH/UGP2/DCXR/GUSB/CRPPA	-0.21561554271384
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/1692	83/9376	0.934689111054146	GSDMD/IRF3/ADAR/CCL4/CCL4L2/GSDME/CASP7/TBK1/MAVS/POLR3A/RIPK1/POLR3B/FADD/CXCL10	-0.28043925973366
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/1692	89/9376	0.933938959279624	ITGA5/SPP1/COL4A1/COL4A2/FN1/HSPG2/DAG1/LAMA5/ITGB1/LAMB1/LAMA4/SDC4/LAMC1/ITGA3/GP1BB	-0.293829117846498
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/1692	54/9376	0.923561859732072	LDHA/PHGDH/DNMT1/KYAT1/ADI1/MTAP/IL4I1/CDO1/PSAT1	-0.264328859576671
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/1692	78/9376	0.923561859732072	TGFB2/MAPK3/TGFB1/ITGB1/FOS/JAK1/MAP3K7/FCGR3A/HLA-DQA1/NOS2/MAPK14/JAK2/TAB1	-0.318093490720686
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1692	31/9376	0.893769541676199	PFKL/H6PD/PGM1/SHPK/RPIA	-0.277992058041475
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/1692	73/9376	0.910910327406976	SMARCB1/NELFE/EP300/SUPT4H1/ELL/TNPO3/HGS/MLLT1/KAT2A/NELFB/SERINC5/MLLT3	-0.35856626047909
NA	NA	hsa04081	Hormone signaling	37/1692	219/9376	0.936213392057169	DIO2/POMC/PIK3CB/AGTR1/PIK3R2/GNG12/CGA/INSR/EPOR/GUCA2A/SLC16A2/GNAI1/ADCY7/GNA12/SMAD4/GNAS/THRB/STK11/ADCY5/PTH1R/BMPR1B/RAPGEF3/ACVR1/PIK3R3/CSH1/AMH/PLCB1/SST/ADCY9/GNA11/SSTR2/MC1R/GIPR/GUCA2B/PLCB3/CRH/JAK2	-0.448195093138082
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1692	38/9376	0.874953340798805	QPRT/NAPRT/NMNAT2/NMRK1/NMNAT3/SIRT5	-0.362434137060194
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	18/1692	110/9376	0.906769825918762	PIK3CB/MAPK3/PIK3R2/AKT3/MAPK9/STK10/GNAI1/ADCY7/RAF1/AKT1/RPS6KA1/ADCY5/PIK3R3/AKT2/SPDYE10/MAPK14/ADCY9/ANAPC13	-0.461528823907249
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1692	26/9376	0.852518639752682	SCARB1/ABCC1/ABCD4/SLC5A6	-0.353354106261953
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	16/1692	100/9376	0.88661938534279	CSF1R/IL10RB/CCL3/IL10RA/TNFSF10/IL2RB/CCR1/CCL4/CCL4L2/IL6ST/ACKR3/XCR1/CCL8/CCL13/CXCL10/CCL28	-0.53487287800676
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	16/1692	100/9376	0.88661938534279	ITGA5/CSF1R/MME/CSF2RA/IL1R1/EPOR/CD14/TFRC/IL11/IL1R2/CD22/HLA-DQA1/ITGA3/IL11RA/CD24/GP1BB	-0.53487287800676
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	26/1692	160/9376	0.900472813238771	CLDN19/PTPRF/ESAM/CLDN7/CD276/HLA-G/F11R/PVR/JAM2/CD274/ITGB1/SIGLEC1/SDC4/CD22/PDCD1LG2/CD99L2/GLG1/MAG/NLGN2/PTPRS/HLA-DQA1/L1CAM/CLDN23/CLDN14/LRRC4/CDH1	-0.595830356814468
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/1692	59/9376	0.84529390551749	TYMP/ENTPD4/UCK2/CANT1/NME2/NME6/CMPK2/CTPS2/ENTPD6	-0.559354994339445
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1692	28/9376	0.791624451198919	ELOVL2/ACOT7/TECR/PPT2	-0.518153647774384
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1692	28/9376	0.791624451198919	ST3GAL6/ST8SIA1/B4GALT2/B4GALT3	-0.518153647774384
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1692	28/9376	0.791624451198919	CA2/ATP6V0A1/ATP6V1C2/ATP6V1E2	-0.518153647774384
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	37/1692	227/9376	0.903219087491278	PIK3CB/HMOX1/MAPK3/PIK3R2/NDUFA6/PRKD3/AKT3/NDUFS1/GSTA3/NDUFS3/MAPK9/FOS/NDUFA7/ARNT/GRB2/RAF1/MAP2K7/AKT1/PTK2/HRAS/SDHA/SOS1/NRAS/MAP3K14/CBR1/PIK3R3/EGFR/MT-ND2/NDUFA13/AKT2/MAPK14/MT-ND5/SLC25A4/PLD2/COX4I2/NOX4/MT-ND1	-0.692640635343189
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1692	103/9376	0.860795519750281	COL4A1/COL4A2/COL27A1/MME/PRCP/DPP4/SLC36A1/COL21A1/ATP1A1/SLC36A4/COL11A1/COL16A1/COL23A1/MEP1A/COL26A1/CTRB2	-0.666582388316427
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	21/1692	133/9376	0.874953340798805	HLA-G/PIK3CB/IFNAR2/VAV3/MAPK3/TNFSF10/PLCG2/RAC3/PIK3R2/PTK2B/VAV2/PAK1/GRB2/RAF1/HRAS/IFNAR1/SOS1/NRAS/FCGR3A/PIK3R3/PLCG1	-0.681527801788926
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1692	91/9376	0.852518639752682	GRK3/CACNA1A/GNG12/GABRE/GNAI1/ADCY7/PDE10A/GNAS/GRK5/ADCY5/GRK4/ADCY9/KCNJ6/KCNJ5	-0.66337487088393
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	49/1692	298/9376	0.911165056245736	IL1RAP/CSF1R/INHA/CSF2RB/TGFB2/GDF15/IFNAR2/TNFRSF25/IL10RB/CCL3/CSF2RA/EBI3/IL10RA/TNFSF10/IL1R1/IL2RB/CCR1/IL13RA1/CCL4/TGFB1/CCL4L2/BMPR2/IL6ST/ACKR3/RELT/LIFR/EPOR/CXCR6/XCR1/RELL2/INHBA/IL11/IFNAR1/IL1R2/RELL1/BMPR1B/ACVR1/CSH1/TNFRSF11A/AMH/IL17D/IL17B/IL11RA/CCL8/CCL13/CXCL10/GDF9/ACVR2B/CCL28	-0.731288954795174
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/1692	67/9376	0.827070322148124	GALM/LDHA/PFKL/ADPGK/ALDH3B2/HK1/PGM1/ALDH1B1/MINPP1/ALDH3A2	-0.666572754132543
Cellular Processes	Cell motility	hsa04814	Motor proteins	31/1692	194/9376	0.885476834588482	KIF12/TPM1/MYO7B/TUBB2A/KIF21A/TUBB/MYH10/MYO10/DNAH11/TNNI2/MYH9/MYO9B/DYNLRB1/TUBA1C/KIF26B/KIF3C/KIF2A/MYO19/DYNC1LI2/DYNLL2/TUBB6/KIF16B/TNNT3/MYO1C/DNAH14/ACTG2/DCTN1/MYO9A/DNAH8/MYO7A/MYL2	-0.756341104780554
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1692	43/9376	0.773214580240805	SCARB1/ABCA1/SLC27A1/AGPAT1/PLPP2/PLA2G10	-0.699408432719348
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1692	30/9376	0.738849487785658	IDH2/ACLY/SDHA/IDH1	-0.672249921931811
Human Diseases	Substance dependence	hsa05034	Alcoholism	30/1692	191/9376	0.870372433255356	MAPK3/CREB3L2/CREB5/GNG12/ATF6B/HDAC5/MAOA/ATF4/GNAI1/GRB2/RAF1/HRAS/GNAS/FOSB/CALM3/SLC29A2/ADCY5/SLC29A1/SOS1/HDAC1/NRAS/HDAC10/CAMKK2/H2BC15/HDAC6/SLC29A3/GRIN2D/CALML4/CRH/GRIN3B	-0.849310731511144
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1692	31/9376	0.715015633340959	UGDH/GUSB/ALDH1B1/ALDH3A2	-0.745769074587935
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1692	17/9376	0.651926018634404	GGT7/CDO1	-0.674021014910763
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1692	38/9376	0.729127783999004	TAP1/TAP2/ADA/DCLRE1C/AICDA	-0.785093648139345
Organismal Systems	Digestive system	hsa04976	Bile secretion	13/1692	90/9376	0.800420278434463	CA2/SCARB1/SLC9A1/RXRA/ADCY7/ATP1A1/GNAS/ADCY5/SLC4A2/ADCY9/KCNN2/ABCG2/ABCC3	-0.892720415926455
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1692	39/9376	0.710432199793902	GCSH/SHMT1/GLDC/AMT/ATIC	-0.850297751117166
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1692	26/9376	0.639388979814512	FADS2/PLA2G10/PLA2G4B	-0.863996538492544
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/1692	86/9376	0.773214580240805	ITGA5/TCF7L2/PKP2/DAG1/ITGB1/TCF7L1/TCF7/ITGA3/DSP/CACNA1C/CACNB3/CTNNA3	-0.991399368682216
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/1692	93/9376	0.774600269452706	ITPR2/SLC9A1/ADCY7/ATP1A1/GNAS/CALM3/ADCY5/SLC4A2/PLCB1/ADCY9/PRH1/PLCB3/CALML4	-1.02504476275294
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	25/1692	168/9376	0.824608803332208	IFNAR2/TNFSF10/CAMK2G/STAT2/MAPK9/RNF31/JAK1/TICAM2/IFNAR1/XIAP/RBCK1/STAT6/TYK2/TRPM7/CHMP1A/SLC25A4/RIPK1/FADD/PYGB/USP21/JAK2/PLA2G4B/TRAF2/TRADD/CHMP7	-1.07639560598197
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1692	61/9376	0.726737201100647	HMOX1/SLC39A4/ATP1A1/HMOX2/TRPM7/SLC11A2/ATP7B/MT1H	-1.00472252677219
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	5/1692	41/9376	0.675776970535663	CACNA1A/SLC17A8/GABRE/GRIN2D/GRIN3B	-0.976271848028545
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/1692	88/9376	0.755641521598968	SERPING1/F13A1/TFPI/C1QA/SERPINE1/C1QB/PROCR/SERPINE2/CD46/VSIG4/C3AR1/C9	-1.080686644454
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/1692	95/9376	0.758292895358965	FLT1/TGFB2/CCL3/TGFB1/FOS/IL11/CTSL/ATP6V0A1/HLA-DQA1/TEK/TNFRSF11A/ATP6V1C2/ATP6V1E2	-1.11108164167795
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1692	20/9376	0.554137115839244	SOAT1/LSS	-0.936619837275288
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/1692	56/9376	0.692671394799054	CLK4/EEF1G/HSF1/CD14/CASP7/APAF1/RAB1A	-1.0823835461522
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1692	63/9376	0.703666178843484	HPGD/PLA2G10/PTGES/HPGDS/CBR1/GPX4/CYP2J2/PLA2G4B	-1.10738550328333
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1692	21/9376	0.527749634132613	ALDH1B1/ALDH3A2	-1.01660488901065
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1692	37/9376	0.599067152258642	MIF/MAOA/ALDH3B2/IL4I1	-1.14660664014351
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/1692	105/9376	0.738849487785658	ITGA5/TPM1/TGFB2/DAG1/TGFB1/ITGB1/ADCY7/GNAS/ADCY5/ITGA3/ADCY9/CACNA1C/CACNB3/MYL2	-1.26274128673368
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/1692	99/9376	0.727654798576785	ITGA5/TPM1/TGFB2/PRKAG2/DAG1/TGFB1/ITGB1/PRKAG1/ITGA3/CACNA1C/CACNB3/PRKAB2/MYL2	-1.27827909375931
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1692	30/9376	0.554137115839244	PLA2G10/CYP2J2/PLA2G4B	-1.147733873956
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1692	46/9376	0.602322951999178	HMOX1/HMOX2/CPOX/GUSB/EARS2	-1.26870531642578
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1692	23/9376	0.481858361599342	FNTB/RCE1	-1.16742525536714
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1692	23/9376	0.481858361599342	CA2/ATP1A1	-1.16742525536714
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1692	102/9376	0.706253186853938	CA2/ITPR2/SLC9A1/ADCY7/ATP1A1/PLA2G10/GNAS/ADCY5/SLC4A2/PLCB1/ADCY9/PLCB3/CTRB2	-1.39968994645717
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/1692	89/9376	0.684888570138391	CACNA1A/GNG12/GABRE/GNAI1/ADCY7/NSF/SLC6A11/ADCY5/ADCY9/KCNJ6/CACNA1C	-1.40156607358786
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	40/1692	275/9376	0.8060176230389	TUBB2A/PIK3CB/ITPR2/TUBB/MAPK3/PIK3R2/CREB3L2/C1QA/CSNK2B/NDUFA6/CREB5/ATF6B/NDUFS1/PSMC4/PSMA2/NDUFS3/C1QB/ATF4/MAPK9/NDUFA7/TUBA1C/PSMA6/APAF1/LAMC1/TUBB6/SDHA/PIK3R3/MT-ND2/NDUFA13/CSNK2A2/MAPK14/MT-ND5/SLC25A4/GRIN2D/COX4I2/CACNA1C/PSMA8/GRIN3B/C9/MT-ND1	-1.53206152380092
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1692	15/9376	0.369424743892829	AK1	-1.14686835946543
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	27/1692	195/9376	0.767266775777414	PIK3CB/MAPK3/GSDMD/PLCG2/PIK3R2/AKT3/HDAC5/RAF1/AKT1/MAP3K7/HDAC1/HDAC10/FCGR3A/PIK3R3/AKT2/H2BC15/PLCB1/HDAC6/MAPK14/SLC25A4/PLCG1/MTOR/AGER/PLCB3/FPR3/ELANE/TLR7	-1.5410716730031
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/1692	34/9376	0.488944513975803	POLR3A/POLR3B/POLR1A	-1.40081157330354
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/1692	50/9376	0.554137115839244	TGFB1/MAP3K14/HLA-DQA1/AICDA/CCL28	-1.48330601241114
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/1692	50/9376	0.554137115839244	TGFB2/HBA2/LRP1/HBA1/TGFB1	-1.48330601241114
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	47/1692	323/9376	0.806329549363605	ITGA5/SOX4/TPM1/TIMP3/CCNE1/TGFB2/PIK3CB/EFNA1/HMOX1/MAPK3/PLCG2/PIK3R2/ERBB3/ERBB2/SLC7A1/RECK/BMPR2/HDAC5/PDGFB/DNMT1/EP300/CRKL/TRIM71/GRB2/RAF1/ABCC1/HRAS/ATM/NOTCH3/PRKCE/BMI1/SOS1/HDAC1/RDX/NRAS/PIK3R3/EGFR/EFNA4/RPS6KA5/BAK1/E2F3/TP53/BMF/PLCG1/MTOR/FGFR3/RPTOR	-1.66211283631101
NA	NA	hsa04082	Neuroactive ligand signaling	27/1692	199/9376	0.751844328023094	SLC6A2/POMC/P2RX4/SLC1A3/GNG12/SLC17A8/CHRM5/GABRE/GNAI1/ADCY7/SLC6A4/SLC6A11/GNAS/ADCY5/SLC1A6/PLCB1/ADCY9/GNAL/GRIK2/GNA11/GRIN2D/TACR3/PLCB3/P2RX6/P2RY6/P2RY1/GRIN3B	-1.6603227469618
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1692	17/9376	0.325963009317202	KYAT1	-1.30522567290151
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1692	17/9376	0.325963009317202	CA2	-1.30522567290151
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/1692	66/9376	0.587721183465864	TGFB2/GATA3/TGFB1/SMAD3/MAF/STAT6/HLA-DQA1	-1.57717646371104
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1692	28/9376	0.39581222559946	AKR1B1/CBR1	-1.50239363998116
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	17/1692	138/9376	0.682632678932401	CCNE1/ITPR2/MAPK3/CAMK2G/ADCY7/SKP1/RPS6KA1/PPP2R5E/CALM3/ADCY5/CUL1/REC8/SPDYE10/MAPK14/ADCY9/ANAPC13/CALML4	-1.76240172670517
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1692	46/9376	0.481858361599342	PSMC4/PSMA2/PSMA6/PSMA8	-1.6530223572247
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1692	29/9376	0.382163528164996	CALM3/CALML4	-1.56361043050193
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/1692	47/9376	0.471606056033399	LDHA/ALDH1B1/ACACA/ALDH3A2	-1.70404615354743
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/1692	31/9376	0.35750781667048	BAG6/SEC61A1	-1.68132310768085
Human Diseases	Immune disease	hsa05310	Asthma	2/1692	32/9376	0.346335697399527	PRG2/HLA-DQA1	-1.73802285049989
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/1692	99/9376	0.55973446044368	C1QA/C1QB/KRT23/C3AR1/FCGR3A/HLA-DQA1/KRT15/FCGR2B/FPR3/DEFA3	-2.06642978094173
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1692	26/9376	0.213129659938171	MAFA	-1.88528140295373
NA	NA	hsa04382	Cornified envelope formation	26/1692	217/9376	0.663943088102319	CLDN19/COL4A1/COL4A2/KRT7/PRSS8/PCSK6/CLDN7/PKP2/SLC27A1/TJP1/PADI1/LAMA5/PPP2R3B/KRT23/UGCG/KAZN/TCHH/SPTLC2/PPP2R5E/GBA2/SPRR2G/KRT15/S100A13/DSP/CLDN23/CLDN14	-2.35023240006841
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/1692	82/9376	0.473043879374964	IMPDH2/GSTA3/TYMP/UCK2/GUSB/NME2/NME6	-2.24891056559798
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1692	27/9376	0.205235968829349	ACADS	-1.94057148519151
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1692	39/9376	0.284172879917561	HLA-G/HLA-DQA1	-2.10198160831958
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/1692	87/9376	0.445857449525828	TPM1/SLC9A1/ATP1A1/COX4I2/CACNA1C/CACNB3/MYL2	-2.43662549243955
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1692	54/9376	0.307853953244024	HLA-G/CGA/HLA-DQA1	-2.39349328173377
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1692	44/9376	0.251880507199656	HLA-G/HLA-DQA1	-2.3340066193479
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	13/1692	138/9376	0.522013225065954	NDUFA6/NDUFS1/NDUFS3/NDUFA7/SDHA/ATP6V0A1/MT-ND2/NDUFA13/MT-ND5/COX4I2/ATP6V1C2/ATP6V1E2/MT-ND1	-2.65435242246182
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1692	45/9376	0.246283162595219	HLA-G/HLA-DQA1	-2.37816793277374
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1692	86/9376	0.386607290120402	CACNA1A/SCN9A/PLCB1/CACNA1C/PLCB3/P2RY1	-2.68146491063939
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1692	68/9376	0.325963009317202	DHRS3/RDH13/RDH10/CYP26A1	-2.61759311376236
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/1692	70/9376	0.316649780479568	HLA-G/RAC3/DAG1/HLA-DQA1	-2.69279302457007
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1692	73/9376	0.303636775802325	GSTA3/MAOA/ALDH3B2/HPGDS	-2.80270821486073
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1692	66/9376	0.251880507199656	CYP11A1/HSD17B8/CYP19A1	-2.86193810782526
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/1692	79/9376	0.280575754855313	GSTA3/ALDH3B2/HPGDS/CBR1	-3.01314019822416
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/1692	243/9376	0.547295916878265	DDX39B/PRPF8/PUF60/SRSF1/PRPF31/SNRNP70/SRSF6/ACIN1/LSM2/DHX16/SF3B1/RBM25/SRSF5/SNRNP200/SRSF7/PRPF3/PRPF19/FUS/DDX23/PRPF40B/DHX38/SNRNP27/THOC6/NCBP1	-3.35508060942291
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/1692	70/9376	0.237487335359676	GSTA3/HPGDS/CBR1	-3.00473860377301
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	16/1692	183/9376	0.484491467400431	CSNK2B/NXF1/FBL/AK6/GNL3/LSG1/RMRP/UTP6/CSNK2A2/NOL6/DROSHA/EMG1/BMS1/GNL3L/WDR36/MDN1	-3.30464575988847
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/1692	143/9376	0.387508472614856	ACTN4/C1QA/C1QB/ACTN1/FCGR3A/HLA-DQA1/H2BC15/TRIM21/ELANE/C9	-3.46328973668034
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	35/1692	370/9376	0.524183758226311	ADM/POMC/P2RX4/AGTR1/EDNRB/CHRM5/CGA/S1PR2/GABRE/PTGER3/CHRNE/KISS1R/THRB/LPAR2/P2RX7/C3AR1/PTH1R/LPAR6/CSH1/F2RL1/SST/GRIK2/GRIN2D/SSTR2/MC1R/CHRNA10/GIPR/TACR3/P2RX6/CRH/EDN3/P2RY6/P2RY1/FPR3/GRIN3B	-4.38193864714224
Genetic Information Processing	Translation	hsa03010	Ribosome	16/1692	222/9376	0.399378101505761	RPS4Y1/RPS17/RPS9/MRPS24/MRPS18B/MRPS12/RPL7A/MRPL45/MRPL46/RPL17/RPS18/RPS10/RPS25/RPL36A/MRPS28/MRPS5	-4.24975932031775
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	11/1692	449/9376	0.135757422588679	GRK3/CAMK2G/NCALD/ANO2/CALM3/OR56A3/OR6C76/GNAL/CALML4/OR8A1/OR2C3	-8.80639580173933