category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	42/671	82/9376	7.15699174875504	HLA-E/HLA-C/HLA-A/HLA-B/HSPA1B/HSPA1A/HLA-DRB1/PSME1/HLA-F/TAPBP/HLA-DRA/HSP90AA1/PSME2/CTSB/TAP1/CANX/HLA-DPB1/TNF/IFI30/HSP90AB1/HSPA6/TAP2/HLA-G/KLRC2/HLA-DPA1/HLA-DQA1/LGMN/B2M/HSPA8/HLA-DRB5/KLRC3/CTSL/HSPA2/HLA-DMA/KIR2DL3/KIR3DL2/HLA-DMB/KLRC4/KIR3DL1/IFNG/CD74/HLA-DQB1	15.5466447307588
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	49/671	180/9376	3.80380857757907	HLA-E/HLA-C/CCL5/HLA-A/HLA-B/HLA-DRB1/HLA-F/TAPBP/HLA-DRA/TAP1/HLA-DPB1/TNF/TNFRSF14/NFKBIA/TAP2/HLA-G/HLA-DPA1/IRF9/HLA-DQA1/BIRC3/B2M/DAXX/SRSF2/HLA-DRB5/LTA/IRF7/HLA-DMA/SRSF7/SRSF1/SOCS3/HLA-DMB/CCL2/SRSF6/BCL2/SRSF3/ITGA5/IFNG/CD74/PIK3R2/OAS1/CGAS/NXF1/IFNAR2/HLA-DQB1/EIF4EBP1/PIK3R3/IFNGR2/TNFSF14/IFIH1	10.5450256833667
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	20/671	45/9376	6.21029971849644	HLA-E/HLA-C/HLA-A/HLA-B/HLA-DRB1/HLA-F/HLA-DRA/HLA-DPB1/TNF/HLA-G/HLA-DPA1/HLA-DQA1/HLA-DRB5/HLA-DMA/KIR2DL3/KIR3DL2/HLA-DMB/KIR3DL1/IFNG/HLA-DQB1	9.72674161382796
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	44/671	205/9376	2.99912035185926	HLA-E/HLA-C/HLA-A/JUN/HLA-B/PLCG2/HLA-DRB1/HLA-F/TAPBP/HLA-DRA/TAP1/HLA-DPB1/TNF/NFKBIB/PSMC4/NFKBIA/TAP2/HLA-G/HLA-DPA1/IRF9/HLA-DQA1/CCND2/B2M/NFKBIE/HLA-DRB5/CDKN1A/IRF7/HLA-DMA/BCL2L11/GADD45B/CCNE1/GADD45G/NFKB2/HLA-DMB/BCL2/PIK3R2/RBPJ/ICAM1/OAS1/IFNAR2/HLA-DQB1/STAT3/PIK3R3/MYC	8.03470682943388
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	19/671	44/9376	6.03387074922097	HLA-E/HLA-C/HLA-A/HLA-B/HLA-DRB1/HLA-F/HLA-DRA/HLA-DPB1/TNF/HLA-G/HSPD1/HLA-DPA1/HLA-DQA1/HLA-DRB5/LTA/HLA-DMA/HLA-DMB/IFNG/HLA-DQB1	9.29187896417965
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	46/671	224/9376	2.86949116457313	HLA-E/HLA-C/HLA-A/JUN/HLA-B/HLA-DRB1/HLA-F/HLA-DRA/GPS2/EGR1/CANX/HLA-DPB1/TNF/NFKBIA/HLA-G/HLA-DPA1/FOS/HLA-DQA1/CCND2/B2M/ZFP36/HLA-DRB5/CDKN1A/LTA/MAD1L1/HLA-DMA/ATF6B/ATF4/EGR2/CCNE1/HRAS/ETS2/NFKB2/HLA-DMB/MSX2/PRKACA/PTEN/NRP1/PIK3R2/PPP3R1/ICAM1/HLA-DQB1/PIK3R3/FOSL1/MYC/SRF	7.8623419985816
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	27/671	95/9376	3.97132324103851	CCL5/CCL3/JUN/HLA-DRB1/CCL3L1/HLA-DRA/FLT1/ATP6V0C/HLA-DPB1/TNF/HLA-DPA1/FOS/HLA-DQA1/VEGFA/LTB/HLA-DRB5/CTSL/HLA-DMA/HLA-DMB/CCL2/TNFSF13/IFNG/CCL20/CXCL2/CXCL3/ICAM1/HLA-DQB1	8.08121807964917
Human Diseases	Immune disease	hsa05330	Allograft rejection	17/671	39/9376	6.09087087775612	HLA-E/HLA-C/HLA-A/HLA-B/HLA-DRB1/HLA-F/HLA-DRA/HLA-DPB1/TNF/HLA-G/HLA-DPA1/HLA-DQA1/HLA-DRB5/HLA-DMA/HLA-DMB/IFNG/HLA-DQB1	8.84470223604109
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	35/671	155/9376	3.15523292149416	HLA-E/HLA-C/HLA-A/HLA-B/HLA-DRB1/HLA-F/HLA-DRA/ATP6V0C/TAP1/CANX/TUBB/HLA-DPB1/TAP2/HLA-G/HLA-DPA1/HLA-DQA1/TUBB4B/CD14/HLA-DRB5/CTSL/HLA-DMA/TUBB2A/MRC1/TFRC/HLA-DMB/OLR1/FCGR2A/TUBA1A/ITGA5/SCARB1/COLEC12/MSR1/CYBB/HLA-DQB1/RILP	7.51161915894013
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	41/671	205/9376	2.7946348733234	HLA-E/HLA-C/HLA-A/JUN/HLA-B/HLA-F/CDC42/ACTN4/YWHAE/CHD4/NFKBIA/DDX3X/HLA-G/IRF9/CCND2/GTF2H1/CDKN1A/MRPS18B/IRF7/MAD1L1/ATF6B/ATF4/EGR2/CCNE1/HRAS/PKM/NFKB2/IL6ST/DNAJA3/PMAIP1/PRKACA/EGR3/GTF2H4/YWHAG/PIK3R2/REL/RBPJ/STAT3/PIK3R3/SCRIB/SRF	7.21285492372741
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	26/671	109/9376	3.33305076634901	JUN/HLA-DRB1/HLA-DRA/HSP90AA1/HLA-DPB1/NFKBIB/IL27RA/HSP90AB1/NFKBIA/HLA-DPA1/FOS/HLA-DQA1/NFKBIE/HLA-DRB5/RXRB/EBI3/HLA-DMA/AHR/HLA-DMB/IL6ST/GATA3/IFNG/PPP3R1/HLA-DQB1/STAT3/IFNGR2	6.80190194619057
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	26/671	112/9376	3.2437726208218	HSPA1B/HSPA1A/HLA-DRB1/HLA-DRA/HLA-DPB1/TNF/NFKBIB/NFKBIA/HSPA6/HLA-DPA1/HLA-DQA1/BIRC3/HSPA8/HLA-DRB5/HLA-DMA/PPIF/HLA-DMB/IL10RB/LDLR/SOCS1/BCL2/IFNG/ALOX5/HLA-DQB1/STAT3/IFNGR2	6.63210041334609
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	44/671	275/9376	2.23570789865872	CCL5/HSPA1B/HSPA1A/EGR1/TUBB/PSMB3/TNF/PSMA2/CSNK2B/NDUFA6/PSMC4/MT-CO3/MT-ND1/HSPA6/C1QA/MT-ATP6/NDUFA3/PSMA6/MT-ND4/NDUFA7/TUBB4B/C1QB/NDUFS3/NDUFS1/HSPA8/MT-ND2/C1QC/MT-ND5/ATF6B/ATF4/TUBB2A/MT-CO1/NDUFA13/PPIF/MT-CYB/PRKACA/TUBA1A/SDHA/PIK3R2/PPP3R1/KLC1/CYBB/MT-CO2/PIK3R3	5.77431036238547
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	16/671	54/9376	4.14019981233096	HLA-E/HLA-C/HLA-A/HLA-B/HLA-DRB1/HLA-F/HLA-DRA/HLA-DPB1/HLA-G/HLA-DPA1/HLA-DQA1/HLA-DRB5/CGA/HLA-DMA/HLA-DMB/HLA-DQB1	6.42483715551968
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	39/671	238/9376	2.28972184999186	RPS9/RPS18/RPL7A/JUN/RPS25/PLCG2/RPS17/RPL17/RPL36A/TNF/NFKBIB/RPS10/NFKBIA/C1QA/FOS/IRF9/F13A1/C1QB/C1QC/MX1/CCL2/IL6ST/FCGR2A/RPS4Y1/RPL26/NRP1/PIK3R2/OAS1/CGAS/IFNAR2/CYBB/STAT3/PIK3R3/C2/C5AR1/RPLP0/IFIH1/HBEGF/NLRP3	5.59527543059713
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	34/671	196/9376	2.42391800237233	HLA-E/HLA-C/HLA-A/JUN/HLA-B/PLCG2/HLA-F/NFKBIA/HLA-G/FOS/IRF9/ZFP36/VEGFA/CDKN1A/IRF7/UBC/HRAS/MICB/GNG10/MAP1LC3A/IL6ST/CXCL2/PIK3R2/CXCL3/PDGFB/CCR1/MICA/PPP3R1/ICAM1/IFNAR2/STAT3/PIK3R3/GNG12/MYC	5.59312063392528
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	18/671	70/9376	3.59310197998723	HLA-E/HLA-C/HLA-A/HLA-B/HLA-DRB1/HLA-F/HLA-DRA/HLA-DPB1/HLA-G/HLA-DPA1/HLA-DQA1/HLA-DRB5/HLA-DMA/HLA-DMB/ICAM1/HLA-DQB1/SGCD/EIF4G2	6.04574190787503
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	31/671	173/9376	2.50386361482732	CCL5/HLA-DRB1/HLA-DRA/DNAJB1/HLA-DPB1/TNF/NFKBIB/NFKBIA/HLA-DPA1/IRF9/HLA-DQA1/HLA-DRB5/IRF7/HLA-DMA/MX1/KPNA2/SOCS3/HLA-DMB/CCL2/PABPN1/IFNG/PIK3R2/ICAM1/OAS1/NXF1/IFNAR2/HLA-DQB1/PIK3R3/IFNGR2/IFIH1/NLRP3	5.54280120930657
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	19/671	78/9376	3.40372196109901	JUN/HLA-DRB1/HLA-DRA/HLA-DPB1/TNF/NFKBIB/NFKBIA/HLA-DPA1/FOS/HLA-DQA1/HLA-DRB5/HLA-DMA/HLA-DMB/FCGR2A/IFNG/CYBB/HLA-DQB1/MARCKSL1/IFNGR2	5.91833129446793
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	37/671	227/9376	2.27756586592435	HLA-E/HLA-C/CCL5/HLA-A/CCL4/CCL3/HLA-B/CCL4L2/HLA-F/CCL3L1/TAPBP/CXCR4/TAP1/TNF/NFKBIA/TAP2/HLA-G/B2M/VEGFA/GNAS/CDKN1A/ATF6B/ATF4/HRAS/GNG10/CCL2/IL10RB/PRKACA/PIK3R2/CCR1/PPP3R1/CGAS/EIF4EBP1/STAT3/PIK3R3/GNG12/MYC	5.40968434959454
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	21/671	93/9376	3.15523292149416	JUN/HLA-DRB1/HLA-DRA/HLA-DPB1/NFKBIB/NFKBIA/HLA-DPA1/FOS/HLA-DQA1/NFKBIE/HLA-DRB5/MAML1/HLA-DMA/HLA-DMB/GATA3/IFNG/RBPJ/PPP3R1/HLA-DQB1/DLL1/IFNGR2	5.79901219369434
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	26/671	133/9376	2.73159799648152	HLA-E/HLA-C/HLA-A/HLA-B/PLCG2/KLRK1/TNF/NCR3/HLA-G/KLRC2/NCR1/KLRC3/KIR2DL3/KIR3DL2/HRAS/MICB/KIR3DL1/IFNG/PIK3R2/MICA/PPP3R1/ICAM1/IFNAR2/PIK3R3/IFNGR2/ULBP2	5.5837881044789
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	32/671	187/9376	2.39113144241574	CCL5/JUN/HSP90AA1/CTSB/GPSM3/YWHAE/TNF/NFKBIB/GABARAP/HSP90AB1/NFKBIA/GSDMD/IRF9/BIRC3/IRF7/GABARAPL1/MAP1LC3A/CCL2/ATG16L1/BCL2/CXCL2/CXCL3/GBP1/OAS1/GBP2/IFNAR2/CYBB/RIPK3/RNF31/GBP5/P2RX7/NLRP3	5.33479032320849
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	35/671	216/9376	2.26417177236849	CCL5/CCL3/JUN/HSPA1B/HSPA1A/CCL3L1/HSP90AA1/CDC42/TNF/HSP90AB1/NFKBIA/HSPA6/HSPD1/FOS/HSPA8/CD14/RXRB/IRF7/HSPA2/ATF4/HRAS/CCL2/OLR1/LDLR/BCL2/ABCA1/CXCL2/PIK3R2/CXCL3/PPP3R1/ICAM1/CYBB/STAT3/PIK3R3/NLRP3	5.21852463600611
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	26/671	142/9376	2.55846854600029	JUN/PLCG2/FOSB/SQSTM1/TNF/NFKBIA/FOS/IRF9/JUND/JUNB/CSF1R/NFKB2/SOCS3/FCGR2A/SOCS1/CYLD/LILRB5/IFNG/PIK3R2/PPP3R1/LILRB1/IFNAR2/PIK3R3/IFNGR2/FOSL1/SIRPA	5.19528993228799
Human Diseases	Immune disease	hsa05310	Asthma	11/671	32/9376	4.80327868852459	PRG2/HLA-DRB1/HLA-DRA/HLA-DPB1/TNF/HLA-DPA1/HLA-DQA1/HLA-DRB5/HLA-DMA/HLA-DMB/HLA-DQB1	5.98314095967444
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	43/671	300/9376	2.0028216592151	JUN/HSPA1B/HSPA1A/FLT1/NR4A1/CDC42/DUSP5/TNF/DUSP8/DUSP2/HSPA6/FOS/JUND/HSPB1/VEGFA/HSPA8/RPS6KA1/DAXX/DUSP1/CD14/FGFR1/ATF4/GADD45B/CSF1R/DUSP9/DUSP10/HRAS/PPM1B/GADD45G/NFKB2/MKNK2/PRKACA/DUSP4/DUSP16/FGF22/PDGFB/PPP3R1/GNG12/MAP3K11/MYC/EFNA1/SRF/MAP4K1	4.90116811729027
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	22/671	110/9376	2.7946348733234	LDHA/PLCG2/FLT1/SERPINE1/EGLN2/VEGFA/CDKN1A/EPAS1/MKNK2/TFRC/EGLN1/BCL2/EGLN3/IFNG/PIK3R2/CYBB/ENO2/EIF4EBP1/STAT3/PIK3R3/IFNGR2/HMOX1	5.25640485682771
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	25/671	137/9376	2.5498493369739	JUN/CTSB/MCL1/TNF/NFKBIA/LMNA/FOS/BIRC3/DAXX/CTSL/BCL2L11/ATF4/GADD45B/HRAS/GADD45G/PMAIP1/BCL2/DAB2IP/CTSZ/TUBA1A/CTSO/PIK3R2/PIK3R3/CTSD/BBC3	5.07340803552896
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	20/671	100/9376	2.7946348733234	CCL5/CCL4/CCL3/CCL4L2/CCL3L1/CXCR4/TNF/TNFRSF14/LTA/CSF1R/CCL2/IL10RB/IL6ST/CCL20/CXCL2/CXCL3/CCR1/CCL8/ACKR3/TNFSF14	5.00908317660584
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	14/671	56/9376	3.49329359165425	HSPA1B/HSPA1A/EEF1G/TNF/NFKBIA/HSPA6/HSPD1/HSPA8/CD14/CLK1/NFKB2/HSF1/CXCL2/CXCL3	5.19543587252805
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	22/671	119/9376	2.58327593332415	CCL5/JUN/TNF/NFKBIA/FOS/BIRC3/JUNB/LTA/ATF6B/ATF4/SOCS3/CCL2/CYLD/DAB2IP/MMP14/CCL20/CXCL2/PIK3R2/CXCL3/ICAM1/RIPK3/PIK3R3	4.82566833348254
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	26/671	157/9376	2.31402887600027	JUN/CDC42/TNF/NDUFA6/MT-CO3/ADIPOR2/FOS/NDUFA3/NDUFA7/NDUFS3/NDUFS1/BCL2L11/ATF4/MT-CO1/NDUFA13/MLXIP/SOCS3/MT-CYB/SREBF1/SDHA/PIK3R2/MT-CO2/PIK3R3/PRKAG1/MAP3K11/CEBPA	4.6097284031126
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	15/671	66/9376	3.17572144695841	JUN/HLA-DRB1/HLA-DRA/HLA-DPB1/TNF/HLA-DPA1/HLA-DQA1/HLA-DRB5/HLA-DMA/HLA-DMB/GATA3/IFNG/HLA-DQB1/STAT3/IFNGR2	4.92450894460142
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/671	101/9376	2.62861696005666	FN1/JUN/PLCG2/CDC42/EGR1/TNF/SERPINE1/COL4A1/VEGFA/HRAS/COL4A2/CCL2/PIM1/BCL2/PIK3R2/ICAM1/CYBB/STAT3/PIK3R3	4.56862162840223
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	19/671	105/9376	2.52847917110212	CCL4/PLCG2/CCL4L2/TNF/CSNK2B/NFKBIA/BIRC3/LTB/CD14/LTA/GADD45B/GADD45G/NFKB2/CYLD/BCL2/CXCL2/CXCL3/ICAM1/TNFSF14	4.37273737375322
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	18/671	99/9376	2.54057715756673	HLA-DRB1/HLA-DRA/HLA-DPB1/C1QA/HLA-DPA1/HLA-DQA1/C1QB/HLA-DRB5/C1QC/KRT18/HLA-DMA/HLA-DMB/FCGR2A/KRT19/ICAM1/HLA-DQB1/C2/C5AR1	4.27818719756454
Human Diseases	Infectious disease: viral	hsa05162	Measles	22/671	136/9376	2.26036644165863	JUN/HSPA1B/HSPA1A/NFKBIB/CSNK2B/NFKBIA/HSPA6/FOS/IRF9/CCND2/HSPA8/IRF7/CCNE1/MX1/BCL2/PIK3R2/OAS1/IFNAR2/STAT3/PIK3R3/IFIH1/BBC3	4.11048256386655
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/671	93/9376	2.55423617454289	FN1/NFKBIA/COL4A1/BIRC3/CKS2/CDKN1A/RXRB/GADD45B/CCNE1/GADD45G/COL4A2/BCL2/PTEN/PIK3R2/TRAF4/PIK3R3/MYC	4.18193061091819
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	22/671	139/9376	2.21158155442859	JUN/HSPA1B/HSPA1A/HSP90AA1/HSP90AB1/HSPA6/FOS/FKBP4/FKBP5/GNAS/HSPA8/KRT18/ATF6B/ATF4/HRAS/PRKACA/BCL2/PIK3R2/KRT19/PIK3R3/CTSD/HBEGF	3.99537080421184
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/671	103/9376	2.44191396698161	CCL5/CCL3/JUN/CCL3L1/TNF/SERPINE1/NFKBIA/C1QA/FOS/PPP2CA/C1QB/GNAS/C1QC/CCL2/IFNG/PIK3R2/PIK3R3/IFNGR2	4.08517195353323
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	38/671	298/9376	1.78181418097801	CCL5/CCL4/CCL3/CCL4L2/CCL3L1/CXCR4/TNF/TNFRSF14/IL27RA/CSH1/LTB/TNFRSF9/LTA/EBI3/INHBA/CSF1R/TNFRSF18/TNFRSF12A/TNFSF9/CCL2/IL10RB/IL6ST/TNFSF13/GDF15/CXCR6/IFNG/CCL20/CXCL2/GDF11/CXCL3/CCR1/RELT/IFNAR2/IL1RN/CCL8/IFNGR2/ACKR3/TNFSF14	3.80784355425138
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	35/671	268/9376	1.82485486131192	TUBB/PSMB3/PSMA2/NDUFA6/PSMC4/MT-CO3/MT-ND1/MT-ATP6/NDUFA3/PSMA6/MT-ND4/SLC39A1/NDUFA7/TUBB4B/NDUFS3/NDUFS1/SLC39A7/GNAS/DAXX/MT-ND2/DUSP1/MT-ND5/UBC/ATF4/TUBB2A/MT-CO1/NDUFA13/PPIF/MT-CYB/PRKACA/TUBA1A/SDHA/KLC1/MT-CO2/SLC39A4	3.80360960021388
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	21/671	133/9376	2.20629068946584	GABARAP/CCND2/CDKN1A/PLK3/BCL2L11/SGK1/GADD45B/GABARAPL1/HRAS/GADD45G/PTEN/CSNK1E/PLK2/PIK3R2/CCNG2/STAT3/PIK3R3/SGK3/PRKAG1/FOXO4/PCK2	3.88985874092567
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	11/671	50/9376	3.07409836065574	HLA-DRB1/HLA-DRA/CXCR4/HLA-DPB1/HLA-DPA1/HLA-DQA1/HLA-DRB5/HLA-DMA/HLA-DMB/TNFSF13/HLA-DQB1	4.08252784370677
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	23/671	157/9376	2.04702554415408	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/SQSTM1/SERPINE1/HLA-G/CCND2/ZFP36L1/RAD50/CDKN1A/GADD45B/CCNE1/HRAS/GADD45G/IGFBP3/PTEN/PIK3R2/PPP3R1/EIF4EBP1/PIK3R3/MYC	3.67305732607851
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	40/671	333/9376	1.67845938337742	HLA-E/HLA-C/HLA-A/FN1/HLA-B/SPP1/HLA-F/ATP6V0C/CDC42/TNF/CHD4/HLA-G/IRF9/CCND2/COL4A1/PPP2CA/VEGFA/GNAS/OASL/CDKN1A/MAML1/CCNE1/HRAS/MX1/PKM/COL4A2/ITGA1/LFNG/PRKACA/PTEN/PPP2R3B/ITGA5/PIK3R2/NOTCH4/RBPJ/IFNAR2/EIF4EBP1/PIK3R3/HES4/SCRIB	3.49987243450988
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/671	94/9376	2.37841265814757	JUN/FOSB/HSP90AA1/TNF/HSP90AB1/NFKBIA/FOS/JUND/SRSF1/CCL2/IFNG/CCL20/CXCL2/CXCL3/TRAF4/FOSL1	3.72893581420427
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	25/671	181/9376	1.92999645947748	HLA-DRB1/HLA-DRA/LSP1/ATP6V0C/HLA-DPB1/TNF/HSPD1/HLA-DPA1/HLA-DQA1/CD14/HLA-DRB5/PLK3/HLA-DMA/MRC1/HLA-DMB/IL10RB/FCGR2A/BCL2/IFNG/CD74/PPP3R1/HLA-DQB1/IFNGR2/SPHK1/CTSD	3.50757710294985
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	15/671	87/9376	2.40916799424431	JUN/FOS/CDKN1A/BCL2L11/GADD45B/HRAS/GADD45G/PMAIP1/BCL2/PIK3R2/PIK3R3/MSH6/RALGDS/MYC/BBC3	3.66606723961453
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	22/671	156/9376	1.97057587221522	YWHAE/TNF/NFKBIA/IRF9/PPP2CA/CDKN1A/IRF7/HRAS/MX1/SOCS3/CLDN7/LDLR/IFNG/SCARB1/YWHAG/PIK3R2/OAS1/IFNAR2/STAT3/PIK3R3/IFIT1/MYC	3.39382027682231
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	16/671	100/9376	2.23570789865872	HLA-DRB1/HLA-DRA/HLA-DPB1/TNF/HLA-DPA1/HLA-DQA1/CD14/HLA-DRB5/HLA-DMA/CSF1R/TFRC/HLA-DMB/ITGA1/CD24/ITGA5/HLA-DQB1	3.44903787303977
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	23/671	168/9376	1.91299410971542	MCL1/IL27RA/IRF9/CCND2/CSH1/CDKN1A/HRAS/SOCS3/IL10RB/PIM1/IL6ST/CISH/SOCS1/BCL2/IFNG/PIK3R2/PDGFB/IFNAR2/STAT3/PIK3R3/SOCS7/IFNGR2/MYC	3.31514456595182
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	41/671	362/9376	1.58259709677154	FN1/SPP1/FLT1/HSP90AA1/NR4A1/MCL1/YWHAE/HSP90AB1/CCND2/COL4A1/CSH1/PPP2CA/VEGFA/CDKN1A/BCL2L11/ATF6B/FGFR1/SGK1/ATF4/CCNE1/CSF1R/HRAS/COL4A2/GNG10/ITGA1/BCL2/PTEN/PPP2R3B/ITGA5/YWHAG/PIK3R2/FGF22/PDGFB/IFNAR2/EIF4EBP1/PIK3R3/GNG12/SGK3/PCK2/MYC/EFNA1	3.13853036707781
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	22/671	160/9376	1.92131147540984	HLA-E/HLA-C/HLA-A/HLA-B/HLA-DRB1/HLA-F/HLA-DRA/HLA-DPB1/HLA-G/HLA-DPA1/HLA-DQA1/HLA-DRB5/HLA-DMA/PTPRM/PTPRF/SDC4/HLA-DMB/F11R/CLDN7/SIGLEC1/ICAM1/HLA-DQB1	3.26330562385163
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	13/671	75/9376	2.42201689021361	SERPINE1/SESN2/CCND2/CDKN1A/GADD45B/CCNE1/GADD45G/IGFBP3/PMAIP1/BCL2/PTEN/CCNG2/BBC3	3.4326780651743
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/671	103/9376	2.17059019287254	FN1/ACTN4/TNF/COL4A1/HSPB1/GNAS/CD14/ARG2/COL4A2/PRDX1/PRKACA/IFNG/CXCL2/PIK3R2/CXCL3/PIK3R3	3.3164684818293
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	27/671	214/9376	1.76297059765728	HLA-E/HLA-C/HLA-A/JUN/HLA-B/PLCG2/HLA-F/TAPBP/CXCR4/TAP1/TNF/SKP1/NFKBIA/TAP2/HLA-G/FOS/B2M/HRAS/GNG10/BCL2/PIK3R2/PPP3R1/CGAS/PIK3R3/APOBEC3D/WEE1/GNG12	3.13459946784866
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	16/671	105/9376	2.12924561777021	JUN/PLCG2/LSP1/TNF/NFKBIA/IRF9/PLK3/EGR2/HRAS/NFKB2/CYLD/EGR3/PIK3R2/PPP3R1/PIK3R3/NLRP3	3.23059326572983
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	28/671	227/9376	1.72356335799681	JUN/NDUFA6/MT-CO3/NFKBIA/MT-ND1/FOS/MT-ATP6/NDUFA3/MT-ND4/NDUFA7/NDUFS3/VEGFA/NDUFS1/MT-ND2/MT-ND5/AHR/HRAS/MT-CO1/NDUFA13/PPIF/MT-CYB/GSTM3/PTEN/SDHA/PIK3R2/MT-CO2/PIK3R3/HMOX1	3.06383371542519
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/671	115/9376	2.06559968897816	EGR1/FOS/JUND/GNAS/CDKN1A/RXRB/ATF6B/FGFR1/SGK1/ATF4/MAFB/PRKACA/BCL2/MMP14/GATA3/GCM1/HBEGF	3.19210062856269
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/671	78/9376	2.32886239443616	BTG2/HSPD1/LSM2/BTG3/PARN/CNOT3/TOB1/TOB2/EXOSC4/DHX36/ENO2/DCP1B/PABPC4	3.27186256243935
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/671	52/9376	2.68714891665711	APOE/PLTP/APOC2/LDLR/LRP1/ANGPTL4/SCARB1/ABCA1/CIDEB/APOC1	3.38700991007895
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/671	70/9376	2.39540131999148	JUN/CDC42/EGLN2/VEGFA/CDKN1A/EPAS1/HRAS/EGLN1/EGLN3/PIK3R2/PDGFB/PIK3R3	3.25333762562559
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/671	71/9376	2.36166327323104	FOS/CCND2/CGA/HRAS/SOCS3/CISH/SOCS1/GALT/PIK3R2/STAT3/PIK3R3/SOCS7	3.19744601014772
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	42/671	388/9376	1.51256011185029	TUBB/PSMB3/TNF/PSMA2/CSNK2B/NDUFA6/PSMC4/MT-CO3/MT-ND1/MT-ATP6/NDUFA3/PSMA6/APOE/MT-ND4/SLC39A1/NDUFA7/TUBB4B/NDUFS3/NDUFS1/SLC39A7/MT-ND2/MT-ND5/ATF4/HRAS/TUBB2A/MT-CO1/NDUFA13/PPIF/MT-CYB/LRP1/CSNK1E/TUBA1A/SDHA/PIK3R2/PPP3R1/KLC1/CYBB/MT-CO2/BACE2/PIK3R3/SLC39A4/APP	2.86280421017492
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/671	109/9376	2.05110816390708	CCL5/CCL4/CCL3/JUN/SPP1/CCL4L2/CCL3L1/TNF/NFKBIA/FOS/IRF9/CD14/IRF7/PIK3R2/IFNAR2/PIK3R3	3.0644573915229
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/671	90/9376	2.17360490147375	JUN/NFKBIB/CSNK2B/NFKBIA/FOS/NFKBIE/HRAS/PTEN/IFNG/PIK3R2/PPP3R1/STAT3/PIK3R3/IFNGR2	3.10592768767606
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/671	46/9376	2.73388194129463	PSME1/PSMB8/PSME2/PSMB9/PSMB3/PSMA2/PSMC4/PSMA6/IFNG	3.27280498424948
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/671	110/9376	2.03246172605338	SMAD7/TNF/SKP1/ID1/PPP2CA/INHBA/ID3/FBN1/TFRC/NOG/TGIF1/BAMBI/LTBP1/IFNG/TGIF2/MYC	3.02403397592828
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	24/671	193/9376	1.73759681242906	CCL5/CCL4/CCL3/PLCG2/CCL4L2/CCL3L1/CXCR4/CDC42/NFKBIB/NFKBIA/HRAS/GNG10/CCL2/CXCR6/PRKACA/CCL20/CXCL2/PIK3R2/CXCL3/CCR1/CCL8/STAT3/PIK3R3/GNG12	2.87453700676756
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	19/671	142/9376	1.86965009130791	JUN/SQSTM1/HSP90AA1/TNF/HSP90AB1/FOS/VEGFA/DUSP1/CTSL/SDC4/CCL2/GSTM3/BCL2/IFNG/PIK3R2/PDGFB/ICAM1/PIK3R3/HMOX1	2.89905393059145
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	21/671	163/9376	1.80022491839851	JUN/TNF/NFKBIA/DDX3X/FOS/HSPG2/CDKN1A/IRF7/ATF6B/ATF4/EGR2/CCNE1/HRAS/EGR3/BCL2/PIK3R2/STAT3/PCNA/PIK3R3/IFIH1/MYC	2.86132933937793
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	22/671	174/9376	1.76672319577916	HSPA1B/HSPA1A/HSPH1/HSP90AA1/DNAJB1/CANX/DNAJA1/PPP1R15A/HSP90AB1/SKP1/HSPA6/RNF5/HSPA8/HYOU1/ATF6B/ATF4/TXNDC5/BCL2/BCAP29/RRBP1/YOD1/DNAJB2	2.8342269443537
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	26/671	217/9376	1.67420522364996	JUN/HSP90AA1/HSP90AB1/FOS/VEGFA/GNAS/RPS6KA1/RXRB/ATF6B/ATF4/KLF4/AHR/HRAS/KPNA2/GSTM3/PRKACA/BCL2/PIK3R2/FGF22/KLF5/EIF4EBP1/STAT3/PIK3R3/DLL1/ADRB1/MYC	2.7897190046556
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	19/671	144/9376	1.84368272892863	TNF/NFKBIA/C1QA/ADIPOR2/C1QB/CD14/C1QC/TRA2B/SREBF1/CXCL2/CXCL3/ACADVL/ACACA/SCD/TRA2A/C2/C5AR1/PRKAG1/ALDH2	2.83253325557774
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	39/671	368/9376	1.48085271820126	SQSTM1/TUBB/PSMB3/TNF/PSMA2/NDUFA6/PSMC4/MT-CO3/MT-ND1/HNRNPA2B1/MT-ATP6/NDUFA3/PSMA6/MT-ND4/NDUFA7/TUBB4B/FUS/NDUFS3/NDUFS1/DAXX/MT-ND2/MT-ND5/CHCHD10/SRSF7/ATF4/TUBB2A/MT-CO1/NDUFA13/MT-CYB/MAP1LC3A/SMCR8/BCL2/TUBA1A/SRSF3/SDHA/PPP3R1/NXF1/KLC1/MT-CO2	2.6126684841916
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/671	88/9376	2.06421894052296	SERPINE2/SERPINE1/C1QA/F13A1/C1QB/C1QC/PLAUR/TFPI/C2/VSIG4/C5AR1/SERPINA1/SERPING1	2.784669943851
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/671	71/9376	2.16485800046179	CCL5/JUN/PLCG2/ATP6V0C/CDC42/NFKBIA/F11R/CXCL2/CXCL3/TJP1/HBEGF	2.73530955794034
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/671	71/9376	2.16485800046179	LDHA/FGFR1/HRAS/PKM/GLS/PTEN/PIK3R2/SLC1A5/PIK3R3/TIGAR/MYC	2.73530955794034
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	13/671	91/9376	1.99616776665957	JUN/PLCG2/NFKBIB/NFKBIA/INPP5D/FOS/NFKBIE/HRAS/LILRB5/PIK3R2/PPP3R1/LILRB1/PIK3R3	2.65109162465364
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/671	157/9376	1.6910211016925	DUSP5/DUSP8/SLC16A1/DUSP2/C1QA/STAB1/C1QB/C1QC/ARG2/SGK1/LRP1/CD24/ABCA1/DUSP4/DUSP16/ALOX5/VPS11/SPHK1/SIRPA	2.42416255669974
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/671	106/9376	1.84551359559092	HSP90AA1/HSP90AB1/NFKBIA/CDKN1A/FGFR1/ATF4/CCNE1/HRAS/FOLR2/BCL2/PTEN/PIK3R2/PDGFB/PIK3R3	2.43050305573804
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/671	248/9376	1.5212730157204	JUN/HSP90AA1/CDC42/TUBB/TNF/HSP90AB1/SKP1/NFKBIA/GSDMD/FOS/RHOB/BIRC3/TUBB4B/DYNLRB1/CD14/HRAS/TUBB2A/BCL2/TUBA1A/CYFIP1/ARPC1B/KLC1/VPS11/RIPK3/MYC/NLRP3/RILP	2.30975427203018
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	17/671	138/9376	1.72133307414847	ATP6V0C/NDUFA6/MT-CO3/MT-ND1/MT-ATP6/NDUFA3/MT-ND4/NDUFA7/NDUFS3/NDUFS1/MT-ND2/MT-ND5/MT-CO1/NDUFA13/MT-CYB/SDHA/MT-CO2	2.37000313490243
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	23/671	205/9376	1.56772200210825	NDUFA6/MT-CO3/MT-ND1/MT-ATP6/NDUFA3/MT-ND4/NDUFA7/NDUFS3/NDUFS1/MT-ND2/MT-ND5/MT-CO1/NDUFA13/PPIF/MT-CYB/PTEN/SDHA/PIK3R2/PDK4/CYBB/MT-CO2/PIK3R3/CTSD	2.2817434894886
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/671	68/9376	2.05487858332603	CD14/CSF1R/HRAS/PIM1/PIK3R2/EIF4EBP1/STAT3/PIK3R3/MYC/CEBPA	2.42376915743571
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/671	78/9376	1.97057587221522	JUN/TNF/C1QA/FOS/C1QB/CD14/C1QC/ITGA5/C2/SERPING1/NLRP3	2.38970631842982
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/671	109/9376	1.7947196434187	TNF/NFKBIA/RPS6KA1/PTPRF/MLXIP/SOCS3/SREBF1/SLC27A3/PTEN/PIK3R2/STAT3/PIK3R3/PRKAG1/PCK2	2.31696848058936
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/671	60/9376	2.09597615499255	PLCG2/CDC42/HSPB1/VEGFA/HRAS/PIK3R2/PPP3R1/PIK3R3/SPHK1	2.36441932985373
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/671	143/9376	1.6611466030244	HLA-DRB1/HLA-DRA/ACTN4/HLA-DPB1/TNF/C1QA/HLA-DPA1/HLA-DQA1/C1QB/HLA-DRB5/C1QC/HLA-DMA/HLA-DMB/FCGR2A/IFNG/HLA-DQB1/C2	2.2118561680821
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/671	70/9376	1.99616776665957	TNF/NFKBIB/NFKBIA/ADIPOR2/NFKBIE/RXRB/SOCS3/STAT3/PRKAG1/PCK2	2.32253619820911
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/671	80/9376	1.92131147540984	PLCG2/VEGFA/BCL2L11/HRAS/BCL2/PTEN/PIK3R2/PDGFB/EIF4EBP1/STAT3/PIK3R3	2.29755505582154
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/671	122/9376	1.71801324179717	PLCG2/FOS/CSH1/JUNB/GNAS/ATF6B/ATF4/HRAS/IGFBP3/SOCS3/SOCS1/PRKACA/PIK3R2/STAT3/PIK3R3	2.21620602901971
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	25/671	235/9376	1.48650791134223	NDUFA6/MT-CO3/MT-ND1/MT-ATP6/NDUFA3/MT-ND4/NDUFA7/SMARCB1/NDUFS3/NDUFS1/GNAS/RPS6KA1/MT-ND2/MT-ND5/FGFR1/HRAS/MT-CO1/NDUFA13/MT-CYB/PRKACA/SDHA/COX16/MT-CO2/SMARCD3/PRKAG1	2.09695685129874
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	19/671	168/9376	1.58029948193883	SQSTM1/HSP90AA1/CHMP4A/TNF/HSP90AB1/IRF9/BIRC3/FTL/GLUL/CYLD/BCL2/IFNG/IFNAR2/CYBB/STAT3/RIPK3/IFNGR2/RNF31/NLRP3	2.10710743224159
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/671	62/9376	2.02836402096053	HSPA1B/HSPA1A/HSPA6/HSPA8/HRAS/PRKACA/PIK3R2/PIK3R3/PRKAG1	2.25547029759288
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	31/671	308/9376	1.40639092651015	POLR2A/TUBB/PSMB3/PSMA2/NDUFA6/PSMC4/MT-CO3/MT-ND1/MT-ATP6/NDUFA3/PSMA6/MT-ND4/POLR2J3/NDUFA7/TUBB4B/NDUFS3/NDUFS1/MT-ND2/MT-ND5/TUBB2A/MT-CO1/NDUFA13/PPIF/MT-CYB/TUBA1A/SDHA/KLC1/SLC1A3/MT-CO2/AP2A2/BBC3	2.01338169565209
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/671	83/9376	1.85186648232273	CCL5/CCL4/CCL4L2/NFKBIB/NFKBIA/GSDMD/IRF7/POLR3E/CGAS/RIPK3/NLRP3	2.16418866924403
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/671	73/9376	1.91413347487904	CDKN1A/FGFR1/GADD45B/HRAS/GADD45G/PTEN/PIK3R2/FGF22/PDGFB/PIK3R3	2.17681761386972
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	26/671	250/9376	1.45321013412817	HLA-E/HLA-C/HLA-A/HLA-B/HSPA1B/HSPA1A/HLA-F/ACAP1/CXCR4/CDC42/CHMP4A/VPS28/HSPA6/HLA-G/HSPA8/RUFY1/HRAS/TFRC/FOLR2/LDLR/IQSEC3/ARPC1B/EHD1/ARFGAP1/AP2A2/EHD4	2.01647060338125
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/671	75/9376	1.86308991554893	BIRC3/CDKN1A/PMAIP1/GSTM3/BCL2/PIK3R2/TOP2A/PIK3R3/MSH6/BBC3	2.08345614019599
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/671	76/9376	1.83857557455487	PLTP/RXRB/UBC/HMGCS1/PLIN2/OLR1/FABP5/ANGPTL4/SCD/PCK2	2.03783980411221
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/671	130/9376	1.61228934999427	JUN/NFKBIA/FOS/COL4A1/VEGFA/GNAS/ATF6B/ATF4/HRAS/COL4A2/GNG10/PRKACA/PIK3R2/PIK3R3/GNG12	1.95170397953839
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/671	37/9376	2.26592016755951	CDKN1A/RXRB/GADD45B/HRAS/GADD45G/MYC	2.14200018309739
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	14/671	120/9376	1.63020367610532	JUN/PLCG2/CDC42/YWHAE/NFKBIB/NFKBIA/NFKBIE/RPS6KA1/ATF4/HRAS/BCL2/PIK3R2/BEX3/PIK3R3	1.92895631712196
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/671	99/9376	1.69371810504448	JUN/FOS/GNAS/CDKN1A/HRAS/PRKACA/BCL2/PIK3R2/NOTCH4/PIK3R3/DLL1/HBEGF	1.92645717297772
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/671	201/9376	1.45988388904954	FLT1/CCND2/BIRC3/FUS/CD14/NFKBIZ/CDKN1A/RXRB/TAF15/KMT2A/GADD45B/CSF1R/GADD45G/IGFBP3/HPGD/REL/MLLT1/BMI1/MYC/CEBPA/EWSR1	1.82980874214308
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/671	122/9376	1.60347902567736	JUN/CDC42/TNF/NFKBIB/NFKBIA/FOS/PPP2CA/NFKBIE/HRAS/PPP2R3B/IFNG/PIK3R2/PPP3R1/PIK3R3	1.86268689383157
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/671	90/9376	1.70783242258652	ADIPOR2/SESN2/EHMT2/ATF6B/ATF4/HRAS/PRKACA/PIK3R2/EIF4EBP1/PIK3R3/PRKAG1	1.87326784063833
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	31/671	323/9376	1.3410786543812	PLCG2/MCL1/TIMP3/CCND2/VEGFA/CDKN1A/SOX4/BCL2L11/CCNE1/HRAS/GLS/MARCKS/TPM1/PIM1/ABCC1/SOCS1/BCL2/PTEN/FOXP1/ITGA5/FSCN1/PIK3R2/PDGFB/NOTCH4/STAT3/PIK3R3/BMI1/HMOX1/SPRY2/MYC/EFNA1	1.73189697028267
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/671	59/9376	1.89466771072773	CDKN1A/GADD45B/HRAS/GADD45G/PTEN/PIK3R2/PIK3R3/MYC	1.91386910682905
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	18/671	169/9376	1.4882670923024	SQSTM1/CTSB/GABARAP/PPP2CA/CTSL/UBC/GABARAPL1/HRAS/MAP1LC3A/ATG16L1/SMCR8/PRKACA/BCL2/PTEN/PIK3R2/VPS11/PIK3R3/CTSD	1.77829679780355
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/671	103/9376	1.62794264465441	DDX39B/PPP2CA/FUS/RBM8A/CPSF1/PCF11/PABPN1/PPP2R3B/EIF4A3/NXF1/PABPC4/NUDT21	1.77906153842144
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/671	50/9376	1.95624441132638	AOC1/SAT1/AMD1/ARG2/P4HA1/ALDH2/GATM	1.88221277673383
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/671	50/9376	1.95624441132638	KLRK1/TNF/CCL2/LRP1/IFNG/ICAM1/HBA2	1.88221277673383
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/671	243/9376	1.38006660411032	HSPA1B/HSPA1A/DDX39B/CWC25/HSPA6/PUF60/PRPF8/DHX16/HNRNPU/LSM2/PRPF31/FUS/HSPA8/RBM8A/SRSF2/SRSF7/SRSF1/TRA2B/SRSF6/RBM25/SRSF3/EIF4A3/TRA2A/ISY1	1.666551078536
NA	NA	hsa04981	Folate transport and metabolism	5/671	31/9376	2.25373780106726	FOLR2/ABCC1/MTHFS/SLCO2B1/SHMT1	1.94115593883801
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/671	138/9376	1.51882330071924	FN1/JUN/CDC42/TNF/NFKBIA/FOS/RPS6KA1/CCL2/FCGR2A/ITGA5/PIK3R2/ARPC1B/PIK3R3/BAIAP2/NLRP3	1.7046394976642
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/671	41/9376	2.04485478535858	VEGFA/CDKN1A/TYMP/HRAS/MYC/HBEGF	1.8614578807237
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/671	32/9376	2.1833084947839	BIRC3/BCL2L11/PMAIP1/BCL2/BBC3	1.86152583149745
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/671	73/9376	1.72272012739114	CXCR4/CHMP4A/SUPT4H1/SMARCB1/NELFE/MX1/MDFIC/APOBEC3D/MLLT1	1.72100677465221
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/671	73/9376	1.72272012739114	PLCG2/CDKN1A/RXRB/GADD45B/HRAS/GADD45G/PIK3R2/STAT3/PIK3R3	1.72100677465221
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/671	52/9376	1.88100424165998	GNAS/CGA/HSD17B1/LDLR/PRKACA/SCARB1/ALOX5	1.76864654202329
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/671	42/9376	1.99616776665957	SAT1/FTL/TFRC/MAP1LC3A/CYBB/HMOX1	1.79632842620066
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/671	23/9376	2.43011728115078	POLD4/SSBP1/PCNA/MSH6	1.90643769266194
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/671	23/9376	2.43011728115078	GLS/ATP1A1/CA2/PCK2	1.90643769266194
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/671	63/9376	1.77437134814184	POLR2A/POLR2J3/POLD4/GTF2H1/ERCC5/GTF2H4/PCNA/CDK7	1.7121320594108
NA	NA	hsa04518	Integrin signaling	16/671	154/9376	1.45175837575241	FN1/SPP1/FLT1/CDC42/ACTN4/CCND2/COL4A1/VEGFA/FBN1/COL4A2/ITGA1/ITGA5/PIK3R2/PDGFB/ICAM1/PIK3R3	1.56933812435272
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/671	15/9376	2.7946348733234	HEXB/ST6GALNAC6/B3GALT4	1.93118162349654
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/671	203/9376	1.37666742528246	FN1/JUN/SPP1/FLT1/CDC42/ACTN4/CCND2/COL4A1/BIRC3/VEGFA/ZYX/HRAS/COL4A2/ITGA1/BCL2/PTEN/ITGA5/PIK3R2/PDGFB/PIK3R3	1.50630492549123
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/671	76/9376	1.65471801709938	PLCG2/CDKN1A/GADD45B/HRAS/GADD45G/PTEN/PIK3R2/PDGFB/PIK3R3	1.59104376063274
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	20/671	204/9376	1.36991905555069	FN1/PLCG2/CDC42/TIMP3/TNF/HSPG2/VEGFA/CDKN1A/CTSL/FGFR1/HRAS/SDC4/PLAUR/PRKACA/ITGA5/PIK3R2/STAT3/PIK3R3/MYC/HBEGF	1.48303798533995
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	24/671	253/9376	1.32551851699134	CCL5/JUN/PLCG2/SQSTM1/CDC42/ACTN4/TNF/NFKBIB/SKP1/NFKBIA/CD14/UBC/MAP1LC3A/ATG16L1/BCL2/ITGA5/PIK3R2/ARPC1B/CGAS/PIK3R3/RNF31/FOXO4/FNBP1L/NLRP3	1.45723512874949
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/671	77/9376	1.63322817272147	CDC42/VEGFA/CDKN1A/GADD45B/GADD45G/PIK3R2/STAT3/PIK3R3/RALGDS	1.54899486461385
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	16/671	158/9376	1.41500499915109	CDKN1C/YWHAE/SKP1/CCND2/PPP2CA/CDKN1A/DDX11/MAD1L1/GADD45B/CCNE1/GADD45G/YWHAG/PCNA/WEE1/MYC/CDK7	1.46058229003527
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/671	89/9376	1.57001959175472	TUBB/TUBB4B/GNAS/HRAS/TUBB2A/PRKACA/TUBA1A/PDGFB/TJP1/ADRB1	1.50006325847761
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	15/671	148/9376	1.4162001047247	JUN/FOS/CDKN1A/FGFR1/GADD45B/HRAS/GADD45G/NFKB2/PTEN/PIK3R2/FGF22/NOTCH4/PIK3R3/DLL1/MYC	1.41690835272046
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/671	47/9376	1.78380949361068	TNF/PKM/SOCS3/SOCS1/PIK3R2/PIK3R3	1.49556196745774
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/671	138/9376	1.41756841400462	FLOT1/PTPRF/HRAS/MKNK2/SOCS3/SREBF1/SOCS1/PRKACA/PIK3R2/ACACA/EIF4EBP1/PIK3R3/PRKAG1/PCK2	1.37195767904509
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/671	69/9376	1.62007818743385	JUN/FOSB/FOS/GNAS/ATF6B/ATF4/PRKACA/PPP3R1	1.43525362805021
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/671	93/9376	1.50249186737817	JUN/CDC42/EGR1/GNAS/CGA/ATF4/HRAS/PRKACA/MMP14/HBEGF	1.35203784105993
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	22/671	238/9376	1.29163796666207	PLCG2/FLT1/CDC42/RASA3/VEGFA/FGFR1/CSF1R/HRAS/ETS2/RGL2/GNG10/PRKACA/SYNGAP1/PIK3R2/FGF22/PDGFB/REL/PIK3R3/GNG12/FOXO4/RALGDS/EFNA1	1.26522997924235
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/671	105/9376	1.46385636221702	JUN/SQSTM1/GABARAP/CSNK2B/UBC/ATF4/GABARAPL1/HRAS/MAP1LC3A/CITED2/RABGEF1	1.32701975235752
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	41/671	480/9376	1.19354197714853	SQSTM1/TUBB/PSMB3/TNF/PSMA2/CSNK2B/NDUFA6/PSMC4/MT-CO3/MT-ND1/MT-ATP6/NDUFA3/PSMA6/MT-ND4/NDUFA7/TUBB4B/FUS/NDUFS3/NDUFS1/DAXX/MT-ND2/MT-ND5/UBC/ATF4/HRAS/TUBB2A/MT-CO1/NDUFA13/PPIF/MT-CYB/MAP1LC3A/SMCR8/BCL2/CSNK1E/TUBA1A/SDHA/PPP3R1/KLC1/CYBB/MT-CO2/APP	1.20853968353396
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/671	49/9376	1.71100094285106	JUN/FOSB/GNAS/ATF6B/ATF4/PRKACA	1.38535073300587
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	9/671	83/9376	1.51516348553678	CSNK2B/SKP1/PHF1/RYBP/RING1/EPOP/BCORL1/BMI1/BCOR	1.30878606136375
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/671	144/9376	1.3585030634211	ID1/FGFR1/KLF4/INHBA/DUSP9/HRAS/ID3/IL6ST/PIK3R2/STAT3/PIK3R3/BMI1/DLX5/MYC	1.20361815472538
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/671	85/9376	1.47951257999474	NME2/IMPDH2/TYMP/NT5C3B/AK6/GMPR2/ADSL/AK4/PNP	1.23293661087353
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	15/671	157/9376	1.33501665923092	SMAD7/YWHAE/SERPINE1/ID1/CCND2/BIRC3/PPP2CA/DLG5/CSNK1E/YWHAG/SCRIB/TEAD1/MYC/TEAD3/BBC3	1.17526778732096
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/671	170/9376	1.31512229332866	JUN/CDC42/ACTN4/RAPGEF6/PPP2CA/ARHGAP17/F11R/CLDN7/PRKACA/TUBA1A/ARPC1B/TJP1/PCNA/AMOTL2/SCRIB/PRKAG1	1.1511465450844
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/671	86/9376	1.46230894534364	JUN/PLCG2/CDKN1A/HRAS/PIK3R2/EIF4EBP1/PIK3R3/MYC/HBEGF	1.19573839879931
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/671	233/9376	1.25938481415861	FN1/LMNA/COL4A1/HSPG2/ZYX/FBLN1/FBN1/COL4A2/BGN/SDC4/ATP1A1/TPM1/ITGA1/ITGA5/MYOM2/ENO2/TTN/DSP/SGCD/CSRP2/FMNL2	1.11311659532554
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/671	98/9376	1.42583411904255	PLCG2/CDC42/INPP5D/MARCKS/FCGR2A/PIK3R2/ARPC1B/PIK3R3/MARCKSL1/SPHK1	1.17649157021214
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/671	122/9376	1.37441059343774	ADIPOR2/PPP2CA/SREBF1/PPP2R3B/PIK3R2/ACACA/SCD/EIF4EBP1/EEF2K/PIK3R3/PRKAG1/PCK2	1.15564862345527
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/671	30/9376	1.86308991554893	TNF/FOLR2/ABCC1/SHMT1	1.31451725687338
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/671	20/9376	2.09597615499255	CYP51A1/SQLE/FDFT1	1.36217688747538
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/671	99/9376	1.41143175420374	JUN/FOS/HRAS/CHKB/PIK3R2/PDGFB/EIF4EBP1/PIK3R3/RALGDS/DGKE	1.14254716478211
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/671	65/9376	1.50480339332798	NR4A1/GNAS/ATF6B/ATF4/LDLR/PRKACA/SCARB1	1.13381785323353
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	12/671	125/9376	1.34142473919523	TNF/PPP2CA/HRAS/ABCC1/BCL2/PTEN/PPP2R3B/PIK3R2/PIK3R3/SPHK1/SGPP1/CTSD	1.06688636037343
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/671	77/9376	1.45175837575241	NFKBIA/CDKN1A/GADD45B/HRAS/GADD45G/PIK3R2/PIK3R3/MYC	1.10508570880435
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/671	89/9376	1.41301763257925	GABARAP/GABARAPL1/GLS/SLC38A2/GNG10/GLUL/PRKACA/NSF/GNG12	1.08689698511649
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/671	32/9376	1.74664679582712	GABARAP/PPP2CA/GABARAPL1/ATG16L1	1.17458997680129
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/671	78/9376	1.43314608888379	PLCG2/INPP5D/ITPK1/PIP4K2B/PTEN/ISYNA1/PLCH2/PI4K2A	1.06647195241553
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/671	55/9376	1.52434629454004	NEU1/HEXB/PSAP/SPHK1/SGPP1/SMPD3	1.08275651252486
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/671	44/9376	1.5878607234792	GTF2H1/TAF15/GTF2H4/TAF9/CDK7	1.08511540372966
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/671	22/9376	1.90543286817504	AOC1/HNMT/ALDH2	1.18040604247671
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/671	105/9376	1.33077851110638	TNF/LMNA/GNAS/TPM1/ITGA1/PRKACA/ITGA5/TTN/ADRB1/SGCD	0.946305049683057
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/671	93/9376	1.35224268064035	CDC42/ACTN4/CSNK2B/PTPRM/FGFR1/PTPRF/TJP1/SNAI1/BAIAP2	0.947767445365894
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/671	69/9376	1.41756841400462	PLCG2/TNF/INPP5D/HRAS/PIK3R2/ALOX5/PIK3R3	0.966517760670687
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/671	23/9376	1.82258796086309	ARG2/GLS/GLUL	1.09656229932234
NA	NA	hsa04517	IgSF CAM signaling	25/671	299/9376	1.16832561593788	PLCG2/CDC42/ACTN4/TUBB/INPP5D/RAPGEF6/TUBB4B/FGFR1/PTPRF/TUBB2A/PPFIA1/F11R/TUBA1A/ITGA5/NRP1/CRTAM/NRP2/PIK3R2/ARPC1B/ICAM1/TJP1/SRGAP3/PIK3R3/APP/BAIAP2	0.821253340917409
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/671	47/9376	1.48650791134223	LDHA/PKM/ACACA/PCK2/ALDH2	0.928290273340514
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/671	59/9376	1.4210007830458	GNAS/CGA/PRKACA/PIK3R2/PIK3R3/ADRB1	0.900602964609947
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/671	72/9376	1.3585030634211	TNF/NFKBIB/NFKBIA/DDX3X/IRF7/CYLD/IFIH1	0.847787051145105
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/671	122/9376	1.25987637731793	PLCG2/DIO2/RXRB/HRAS/ATP1A1/PRKACA/PIK3R2/NOTCH4/PIK3R3/MED17/MYC	0.802129488267129
NA	NA	hsa03272	Virion - Hepatitis viruses	5/671	48/9376	1.4555389965226	CHMP4A/HSPG2/CLDN7/LDLR/SCARB1	0.878444688688234
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/671	200/9376	1.18771982116244	JUN/CDC42/TUBB/TNF/NFKBIB/NFKBIA/FOS/TUBB4B/TUBB2A/CLDN7/FCGR2A/TUBA1A/CYFIP1/ARPC1B/TJP1/BAIAP2/NLRP3	0.745008002488146
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/671	98/9376	1.2832507071383	PLCG2/INPP5D/ITPK1/PIP4K2B/PTEN/PIK3R2/PIK3R3/PI4K2A/DGKE	0.782563102163109
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	13/671	149/9376	1.2191360185639	NDUFA6/MT-ND1/NDUFA3/MT-ND4/NDUFA7/NDUFS3/NDUFS1/MT-ND2/MT-ND5/NDUFA13/GNG10/PRKACA/GNG12	0.748581605529734
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/671	61/9376	1.37441059343774	HMOX2/FTL/ATP1A1/SLC39A4/HMOX1/SLC30A1	0.814486942832574
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/671	37/9376	1.51061344503967	TNF/IFNG/ICAM1/HBA2	0.863983464988567
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/671	62/9376	1.35224268064035	MAML1/NRARP/LFNG/NOTCH4/RBPJ/DLL1	0.772559995814267
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/671	38/9376	1.47086045964389	SGK1/ATP1A1/PIK3R2/PIK3R3	0.807457357778354
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/671	75/9376	1.30416294088425	CANX/GNAS/CGA/ATF6B/ATF4/ATP1A1/PRKACA	0.734234215217682
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/671	63/9376	1.33077851110638	EHMT2/KMT2A/PLOD2/PLOD1/KMT5C/ALDH2	0.731350010286888
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/671	51/9376	1.36991905555069	PLCG2/ATP6V0C/GNAS/PRKACA/TJP1	0.735410594223664
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	19/671	232/9376	1.14435479726605	FN1/CXCR4/CDC42/ACTN4/RGCC/FGFR1/HRAS/SPATA13/PIP4K2B/ITGA1/ITGA5/CYFIP1/PIK3R2/FGF22/ARPC1B/PDGFB/PIK3R3/GNG12/BAIAP2	0.618115473315239
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/671	89/9376	1.25601567340377	FN1/SPP1/COL4A1/HSPG2/COL4A2/SDC4/ITGA1/ITGA5	0.67373071175536
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/671	116/9376	1.20458399712215	PLCG2/CXCR4/CDC42/ACTN4/F11R/CLDN7/PIK3R2/ICAM1/CYBB/PIK3R3	0.615541971721626
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/671	116/9376	1.20458399712215	GRIK4/GNAS/GLS/SLC38A2/GNG10/GLUL/PRKACA/PPP3R1/SLC1A3/GNG12	0.615541971721626
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/671	28/9376	1.49712582499468	ATP6V0C/CA2/SLC12A7	0.731389125921918
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/671	41/9376	1.36323652357239	POLD4/RAD50/SSBP1/TOP3A	0.64712292927716
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/671	29/9376	1.44550079654659	CSNK1E/TEAD1/TEAD3	0.667073783740713
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/671	17/9376	1.64390286666082	CA2/GLUL	0.737721781227897
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/671	17/9376	1.64390286666082	TFRC/NRP2	0.737721781227897
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/671	107/9376	1.17531373177152	LDHA/GNAS/ATF4/PKM/PRKACA/PPP3R1/ACACA/PRKAG1/PCK2	0.506353589101928
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/671	43/9376	1.29983017363879	DGAT1/SCARB1/ABCA1/AGPAT1	0.547093357313738
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/671	18/9376	1.55257492962411	NEU1/HEXB	0.651475997813812
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	14/671	178/9376	1.0990137142283	JUN/NOTUM/CSNK2B/SKP1/CCND2/SFRP1/PRKACA/BAMBI/CSNK1E/PPP3R1/FOSL1/GPC4/MYC/CACYBP	0.370272246714289
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/671	19/9376	1.47086045964389	IDS/HEXB	0.570378594285031
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/671	98/9376	1.14066729523404	NR4A1/GNAS/ATF6B/ATF4/ATP1A1/LDLR/PRKACA/SCARB1	0.388634634114075
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/671	45/9376	1.24205994369929	TAP1/TAP2/ABCC1/ABCA1	0.451884662040162
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/671	32/9376	1.30998509687034	LDHA/BCKDHA/ACACA	0.487654122105126
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/671	99/9376	1.12914540336299	TNF/LMNA/TPM1/ITGA1/ITGA5/TTN/PRKAG1/SGCD	0.358637156586503
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/671	46/9376	1.21505864057539	HMOX2/FTL/ALAS1/HMOX1	0.405935937169701
Genetic Information Processing	Translation	hsa03010	Ribosome	17/671	222/9376	1.0700178569031	RPS9/RPS18/RPL7A/RPS25/RPS17/RPL17/RPL36A/RPS10/MRPS24/MRPS12/MRPS18B/MRPL38/RPS4Y1/RPL26/MRPL45/MRPL23/RPLP0	0.293117911463123
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	19/671	250/9376	1.06196125186289	ATP6V0C/CTSB/NEU1/IDS/LGMN/HEXB/BORCS5/CLN8/CTSL/PSAP/CD68/CLN3/CTSZ/CTSO/VPS11/SLC2A6/AP2A2/CTSD/CLN6	0.27568457437646
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/671	155/9376	1.08179414451228	NR4A1/GNAS/CDKN1A/ATF6B/KMT2A/ATF4/AHR/CCNE1/LDLR/PRKACA/SCARB1/RASD1	0.285076595146679
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/671	115/9376	1.09355277651785	FOS/ATF4/HRAS/GNG10/PRKACA/BCL2/PIK3R2/PIK3R3/GNG12	0.280245836982914
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/671	34/9376	1.23292714999562	POLR2A/POLR2J3/POLR3E	0.37774797985214
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/671	34/9376	1.23292714999562	SKP1/CSNK1E/PRKAG1	0.37774797985214
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/671	170/9376	1.06853686332953	PLCG2/SMARCB1/CDKN1A/GADD45B/HRAS/GADD45G/GSTM3/PTEN/PIK3R2/PIK3R3/SMARCD3/HMOX1/MYC	0.250366207351856
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/671	184/9376	1.06317631050347	PLCG2/CXCR4/CDC42/HRAS/SEMA7A/NRP1/PIK3R2/PPP3R1/SRGAP3/EFNB2/PIK3R3/SEMA4C/RND1/EFNA1	0.240281687718565
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/671	21/9376	1.33077851110638	CHPF/CHSY1	0.421296207890046
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/671	117/9376	1.07485956666285	CHD4/INO80D/SMARCB1/INO80B/SRCAP/TFPT/SMARCA5/SMARCD3/CHD3	0.22621464016539
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/671	63/9376	1.10898209258865	HPGD/ALOX5/HPGDS/PRXL2B/PTGES	0.24095898572493
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/671	36/9376	1.16443119721808	POLD4/SSBP1/PCNA	0.27442554900605
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/671	78/9376	1.07485956666285	FN1/CDC42/ITGA5/PIK3R2/ARPC1B/PIK3R3	0.184315708406001
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/671	23/9376	1.21505864057539	B3GAT1/B3GALNT2	0.286686905982737
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/671	37/9376	1.13296008377976	GLS/GLUL/ADSL	0.224975105934153
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/671	65/9376	1.07485956666285	ABHD16A/DGAT1/AGPAT1/ALDH2/DGKE	0.168138951301607
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/671	65/9376	1.07485956666285	SPP1/CGA/HRAS/PIK3R2/PIK3R3	0.168138951301607
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/671	150/9376	1.02469945355191	CDKN1A/RXRB/GADD45B/CCNE1/HRAS/GADD45G/BCL2/PIK3R2/FGF22/PIK3R3/MYC	0.0846620460609637
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/671	38/9376	1.10314534473292	HEXB/GALT/UAP1L1	0.176879297930791
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/671	38/9376	1.10314534473292	SIRT2/NAPRT/PNP	0.176879297930791
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/671	67/9376	1.04277420646395	LDHA/PKM/ENO2/PCK2/ALDH2	0.097550692810402
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/671	67/9376	1.04277420646395	RPS6KA1/ATF4/HRAS/PRKACA/PPP3R1	0.097550692810402
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/671	138/9376	1.01254886714616	YWHAE/SKP1/PPP2CA/RPS6KA1/MAD1L1/CCNE1/PRKACA/YWHAG/PPP3R1/REC8	0.0412304045686232
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/671	53/9376	1.05457919748053	GNAS/ATP1A1/PRKACA/AP2A2	0.110624099597027
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/671	140/9376	0.998083883329785	SPP1/EGR1/SERPINE1/HRAS/GNG10/MAP1LC3A/PRKACA/GNG12/SPHK1/PRKAG1	-0.00634171200393138
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/671	83/9376	1.01010899035785	ECH1/PHYH/DHRS4/PRDX1/ECI2/AMACR	0.0256821495433337
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/671	69/9376	1.01254886714616	CTSB/GNAS/PRKACA/PPP3R1/ADRB1	0.0290460259116364
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	15/671	212/9376	0.988667997637995	FLT1/CDC42/ID1/RAPGEF6/VEGFA/GNAS/FGFR1/CSF1R/HRAS/PIK3R2/FGF22/PDGFB/PIK3R3/RALGDS/EFNA1	-0.0463334412574956
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/671	26/9376	1.07485956666285	ABCC1/SCARB1	0.106118398685603
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/671	41/9376	1.02242739267929	ALAS1/SHMT1/GATM	0.0399554535538884
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/671	56/9376	0.998083883329785	CCND2/PRKACA/BCL2/CSNK1E	-0.00399273527903283
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/671	115/9376	0.972046912460312	GNAS/DUSP1/HRAS/GNG10/PRKACA/ALOX5/GNG12/APP	-0.083736011964558
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/671	87/9376	0.963667197697723	MT-CO3/MT-CO1/MT-CYB/ATP1A1/TPM1/MT-CO2	-0.0945227941507411
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/671	43/9376	0.974872630229092	ACADVL/ECI2/ALDH2	-0.0458493450528796
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/671	133/9376	0.945553152628217	FOS/PPP2CA/GNAS/ATF6B/ATF4/GNG10/PRKACA/PPP2R3B/GNG12	-0.175571731602072
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/671	44/9376	0.952716434087522	HEXB/MGAT4B/ALG9	-0.0872793906203391
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/671	44/9376	0.952716434087522	GNAS/PRKACA/NSF	-0.0872793906203391
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/671	13/9376	1.07485956666285	RAD50	0.0749849288660407
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/671	149/9376	0.937796937356845	PLCG2/GNAS/HRAS/PIK3R2/PDGFB/PIK3R3/SPHK1/AGPAT1/RALGDS/DGKE	-0.212489342498033
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/671	75/9376	0.931544957774466	ARG2/PKM/GLUL/ENO2/SHMT1	-0.16524706810119
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/671	90/9376	0.931544957774466	GNAS/ATP1A1/CA2/LDLR/PRKACA/SCARB1	-0.181165237757892
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/671	30/9376	0.931544957774466	SDHA/PCK2	-0.104259513063861
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/671	31/9376	0.901495120426902	GLUL/SHMT1	-0.152514610172134
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/671	154/9376	0.907348984845259	NME2/NAPRT/AK6/ADSL/AK4/RDH13/ALAS1/SHMT1/PDXP/ALDH2	-0.321855173354889
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/671	154/9376	0.907348984845259	PPP2CA/GNAS/ATF6B/ATF4/ATP1A1/TPM1/PRKACA/BCL2/PPP2R3B/ADRB1	-0.321855173354889
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/671	154/9376	0.907348984845259	JUN/FOS/GNAS/CDKN1A/HRAS/PRKACA/PPP3R1/RGS2/EEF2K/PRKAG1	-0.321855173354889
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/671	15/9376	0.931544957774466	AK4	-0.0736635187172184
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/671	79/9376	0.88437812446943	ATP6V0C/NSF/SLC1A3/SLC6A2/AP2A2	-0.286513210155996
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/671	48/9376	0.873323397913562	HMGCS1/BCKDHA/ALDH2	-0.244278512121592
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/671	48/9376	0.873323397913562	ATP1A1/PIK3R2/PIK3R3	-0.244278512121592
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/671	110/9376	0.889202005148354	HSP90AA1/HSP90AB1/RPS6KA1/MAD1L1/PRKACA/PIK3R2/PIK3R3	-0.324522345420853
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/671	49/9376	0.85550047142553	GALNT4/LFNG/C1GALT1C1	-0.281550298691487
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/671	16/9376	0.873323397913562	MIF	-0.140792974109559
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/671	16/9376	0.873323397913562	HEXB	-0.140792974109559
NA	NA	hsa04382	Cornified envelope formation	14/671	217/9376	0.901495120426902	KRT7/COL4A1/PPP2CA/KRT18/COL4A2/CLDN7/PRSS8/PPP2R3B/KRT19/TJP1/COL17A1/KRT8/DSP/PCSK6	-0.407592413936937
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/671	97/9376	0.864320063914453	FOS/GNAS/GNG10/PRKACA/GNG12/RASD1	-0.372918063776972
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	10/671	158/9376	0.88437812446943	TNF/SESN2/RPS6KA1/SGK1/HRAS/PTEN/PIK3R2/EIF4EBP1/PIK3R3/CASTOR1	-0.406923444503213
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/671	144/9376	0.873323397913562	PSMB3/PSMA2/PSMC4/PSMA6/PPIF/PIK3R2/RBPJ/NOP56/PIK3R3	-0.425296946126982
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/671	17/9376	0.821951433330411	AMACR	-0.203990869662881
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/671	18/9376	0.776287464812055	ACACA	-0.263753093511076
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/671	18/9376	0.776287464812055	PRDX1	-0.263753093511076
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/671	36/9376	0.776287464812055	GALNT4/C1GALT1C1	-0.373362453884364
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/671	86/9376	0.812393858524244	GNAS/ATF6B/ATF4/ATP1A1/PRKACA	-0.485233672141891
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/671	86/9376	0.812393858524244	LMNA/ITGA1/ITGA5/DSP/SGCD	-0.485233672141891
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/671	37/9376	0.755306722519837	GALT/UAP1L1	-0.414033253120261
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/671	103/9376	0.813971322327203	COL4A1/SLC38A2/COL4A2/ATP1A1/SLC1A5/COL17A1	-0.527048876690349
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/671	19/9376	0.735430229821947	BCKDHA	-0.320487589292589
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/671	104/9376	0.806144674997134	CHKB/CRLS1/LPCAT1/MBOAT7/AGPAT1/DGKE	-0.551912466384557
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/671	38/9376	0.735430229821947	TAP1/TAP2	-0.453698761916773
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/671	20/9376	0.698658718330849	UAP1L1	-0.374533813771447
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/671	39/9376	0.716573044441897	MTHFS/SHMT1	-0.492416147997844
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/671	57/9376	0.735430229821947	ACADVL/ACACA/SCD	-0.556231401120796
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/671	21/9376	0.66538925555319	ALDH2	-0.426177133705549
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/671	76/9376	0.735430229821947	GNAS/ATP1A1/CA2/PRKACA	-0.642936456764615
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/671	59/9376	0.710500391522898	NME2/TYMP/NT5C3B	-0.619296248718702
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/671	93/9376	0.751245933689086	GNAS/ATP1A1/PRKACA/PRH1/ADRB1	-0.669314137410253
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/671	142/9376	0.787221091077014	SKP1/BIRC3/UBC/HERC2/SOCS3/HERC3/SOCS1/UBE2S	-0.709316929217387
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/671	42/9376	0.66538925555319	AOC1/ALDH2	-0.603383096782512
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/671	60/9376	0.698658718330849	PPP2CA/GNAS/HRAS	-0.650102785554019
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/671	254/9376	0.825187462595491	PLCG2/FLT1/CXCR4/VEGFA/GNAS/FGFR1/P2RX5/PPIF/PRKACA/FGF22/PDGFB/PPP3R1/SPHK1/ADRB1/P2RX7	-0.784164019965506
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/671	23/9376	0.607529320287695	HMGCS1	-0.523188487356865
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/671	128/9376	0.764157973174367	NME2/IMPDH2/AK6/GMPR2/ADSL/AK4/PNP	-0.745872823167158
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/671	24/9376	0.582215598609041	NDST2	-0.56894214166811
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/671	44/9376	0.635144289391681	POLD4/PCNA	-0.673476787795338
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/671	63/9376	0.66538925555319	CDKN1A/GADD45B/GADD45G	-0.739823063398987
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/671	99/9376	0.705715877101868	PLCG2/GNAS/PRKACA/PIK3R2/PIK3R3	-0.817227855706907
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/671	82/9376	0.681618261786195	NME2/IMPDH2/TYMP/GSTM3	-0.803926328758253
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/671	27/9376	0.51752497654137	HMGCS1	-0.697006211891441
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/671	27/9376	0.51752497654137	SCD	-0.697006211891441
NA	NA	hsa04081	Hormone signaling	12/671	219/9376	0.765653389951616	ADIPOR2/CSH1/GNAS/DIO2/CGA/GNG10/PRKACA/PIK3R2/STAT3/PIK3R3/GNG12/ADRB1	-0.974241524906663
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/671	68/9376	0.616463574997808	DGAT1/DHRS4/RDH13	-0.88124242198797
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/671	28/9376	0.499041941664892	B3GNT5	-0.737027243380845
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/671	30/9376	0.465772478887233	B3GALT4	-0.813647898032481
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/671	108/9376	0.646906220676712	DDX39B/RBM8A/KPNA2/EIF4A3/NXF1	-1.02464032140702
Organismal Systems	Immune system	hsa04611	Platelet activation	6/671	126/9376	0.66538925555319	PLCG2/GNAS/FCGR2A/PRKACA/PIK3R2/PIK3R3	-1.049824729971
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/671	194/9376	0.720266719928711	TUBB/TUBB4B/DYNLRB1/KIF21A/TUBB2A/TPM1/TUBA1A/KLC1/MYO19/CENPE	-1.09304708173279
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/671	91/9376	0.614205466664483	GNAS/GNG10/PRKACA/GNG12	-1.02671125325868
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/671	31/9376	0.450747560213451	ALDH2	-0.850404793175514
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/671	31/9376	0.450747560213451	ALDH2	-0.850404793175514
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/671	31/9376	0.450747560213451	BAG6	-0.850404793175514
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/671	54/9376	0.51752497654137	LDHA/AMD1	-0.987142106421008
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/671	32/9376	0.436661698956781	GALT	-0.886217587287201
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/671	33/9376	0.423429526261121	BCKDHA	-0.921146496008782
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/671	33/9376	0.423429526261121	STX16	-0.921146496008782
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/671	166/9376	0.673405993571903	ATF6B/ATF4/PPIF/ATP1A1/PPP3R1/RGS2/ADRB1/SRF	-1.17867738223555
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/671	56/9376	0.499041941664892	MGAT4B/ALG9	-1.04387845684045
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/671	35/9376	0.399233553331914	TIGAR	-0.988565649587658
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/671	59/9376	0.473666927681932	GSTM3/HPGDS	-1.12592931982825
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/671	36/9376	0.388143732406028	PGM2L1	-1.02115045677478
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/671	37/9376	0.377653361259919	MIF	-1.05304161217467
NA	NA	hsa04082	Neuroactive ligand signaling	9/671	199/9376	0.631952609545492	GRIK4/GNAS/P2RX5/GNG10/PRKACA/SLC1A3/SLC6A2/GNG12/ADRB1	-1.45694254557371
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/671	70/9376	0.399233553331914	GSTM3/HPGDS	-1.40066951145682
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/671	226/9376	0.618282051620221	JUN/NFKBIA/FOS/GNAS/CGA/ATP1A1/PRKACA/PIK3R2/PIK3R3/ADRB1	-1.61268209458221
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/671	191/9376	0.585263847816418	FOSB/GNAS/ATF6B/ATF4/HRAS/GNG10/PRKACA/GNG12	-1.6077240481583
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/671	116/9376	0.481833598848862	PKM/SDHA/ENO2/SHMT1	-1.55903283116532
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/671	73/9376	0.382826694975808	GSTM3/HPGDS	-1.46966909987037
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/671	195/9376	0.573258435553518	PLCG2/GSDMD/PPIF/FCGR2A/PIK3R2/CYBB/PIK3R3/C5AR1	-1.67185946240327
NA	NA	hsa04519	Cadherin signaling	20/671	404/9376	0.691741305278069	CDC42/ACTN4/YWHAE/NFKBIA/KRT7/KRT18/FGFR1/HRAS/YWHAG/CYFIP1/ARPC1B/KRT19/TJP1/LHFPL6/KRT8/DSP/AMOTL2/TEAD1/LHFPL2/TEAD3	-1.7584251869453
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/671	51/9376	0.273983811110137	LPCAT1	-1.44334277695607
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/671	101/9376	0.415044783166841	GNAS/HRAS/PRKACA	-1.64092547284888
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/671	183/9376	0.53449300855912	CSNK2B/FBL/RMRP/AK6/NXF1/NOP56/GNL3	-1.76557281555156
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/671	102/9376	0.410975716665206	GNAS/ATP1A1/CA2	-1.66058935727676
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/671	79/9376	0.353751249787772	GSTM3/HPGDS	-1.60141671403393
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/671	54/9376	0.258762488270685	TOP3A	-1.51656919655963
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/671	86/9376	0.324957543409697	PRKACA/SCN9A	-1.74596272534779
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/671	66/9376	0.21171476313056	HSD17B1	-1.78419792905365
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/671	134/9376	0.312832261939186	GNAS/ADM/PRKACA	-2.22430679820462
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/671	370/9376	0.377653361259919	GRIK4/CSH1/CGA/P2RX5/ADM/LTB4R/CHRNB1/C5AR1/ADRB1/P2RX7	-3.3910153022048
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/671	449/9376	0.0622413112098752	PRKACA/RGS2	-5.65358609894459