ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0042605 peptide antigen binding 21/1206 45/18639 0.466666666666667 7.21243781094527 7.62776990689093e-14 7.17978453034416e-11 GO:0023023 MHC protein complex binding 19/1206 37/18639 0.513513513513513 7.93646631706333 1.28554781205804e-13 7.17978453034416e-11 GO:0023026 MHC class II protein complex binding 16/1206 27/18639 0.592592592592593 9.15865118850193 5.66709245404881e-13 2.11004742372417e-10 GO:0042277 peptide binding 40/1206 249/18639 0.160642570281124 2.48276688844932 8.68048332255395e-08 2.42402496782319e-05 GO:0051082 unfolded protein binding 24/1206 121/18639 0.198347107438017 3.06549895152338 7.25707411133532e-07 0.000155482451738172 GO:0031072 heat shock protein binding 25/1206 131/18639 0.190839694656489 2.9494702062208 9.15260186317249e-07 0.000155482451738172 GO:0044183 protein folding chaperone 18/1206 75/18639 0.24 3.70925373134328 9.74375257087914e-07 0.000155482451738172 GO:0038024 cargo receptor activity 16/1206 65/18639 0.246153846153846 3.80436280137773 2.70590474394149e-06 0.00037781194987283 GO:0140597 protein carrier chaperone 30/1206 188/18639 0.159574468085106 2.4662591298825 3.9873820904307e-06 0.000494878421667899 GO:0140297 DNA-binding transcription factor binding 58/1206 488/18639 0.118852459016393 1.83689136285784 5.30632079112199e-06 0.000592716032368326 GO:0042287 MHC protein binding 12/1206 41/18639 0.292682926829268 4.52348016017474 6.95165052244118e-06 0.000705908512142436 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 45/1206 349/18639 0.128939828080229 1.99279391010563 7.61881114466905e-06 0.000709184337382944 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 6/1206 10/18639 0.6 9.27313432835821 1.21406880707805e-05 0.000968653469647275 GO:0030957 Tat protein binding 6/1206 10/18639 0.6 9.27313432835821 1.21406880707805e-05 0.000968653469647275 GO:0071813 lipoprotein particle binding 10/1206 32/18639 0.3125 4.82975746268657 2.14890266114576e-05 0.00150020267031239 GO:0071814 protein-lipid complex binding 10/1206 32/18639 0.3125 4.82975746268657 2.14890266114576e-05 0.00150020267031239 GO:0140104 molecular carrier activity 34/1206 249/18639 0.136546184738956 2.11035185518192 2.96747717214219e-05 0.00194980705957813 GO:0140662 ATP-dependent protein folding chaperone 11/1206 40/18639 0.275 4.25018656716418 3.21296485313232e-05 0.001993823189416 GO:0005126 cytokine receptor binding 36/1206 275/18639 0.130909090909091 2.02322930800543 4.36728092012474e-05 0.00235529862657743 GO:0019207 kinase regulator activity 37/1206 287/18639 0.128919860627178 1.9924853086484 4.7954076961979e-05 0.00235529862657743 GO:0019887 protein kinase regulator activity 34/1206 255/18639 0.133333333333333 2.06069651741294 4.85239291034334e-05 0.00235529862657743 GO:0060590 ATPase regulator activity 12/1206 49/18639 0.244897959183673 3.78495278708498 5.01568687236858e-05 0.00235529862657743 GO:0030169 low-density lipoprotein particle binding 7/1206 17/18639 0.411764705882353 6.36391571553995 5.10088547357357e-05 0.00235529862657743 GO:0035198 miRNA binding 11/1206 42/18639 0.261904761904762 4.04779673063255 5.27870140581229e-05 0.00235529862657743 GO:0140713 histone chaperone activity 25/1206 164/18639 0.152439024390244 2.35597925009101 5.41776189500124e-05 0.00235529862657743 GO:0003823 antigen binding 26/1206 174/18639 0.149425287356322 2.3094012695145 5.4823423716216e-05 0.00235529862657743 GO:0031625 ubiquitin protein ligase binding 38/1206 302/18639 0.125827814569536 1.94469704457843 6.47713879796637e-05 0.00260384615372943 GO:0140375 immune receptor activity 24/1206 156/18639 0.153846153846154 2.37772675086108 6.52709868437099e-05 0.00260384615372943 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 14/1206 68/18639 0.205882352941176 3.18195785776997 9.53341035992399e-05 0.0036720066800121 GO:0008186 ATP-dependent activity, acting on RNA 15/1206 79/18639 0.189873417721519 2.93453617986019 0.000142915279647557 0.00532121224554403 GO:0140313 molecular sequestering activity 12/1206 55/18639 0.218181818181818 3.37204884667571 0.000166373698609931 0.00575500886785139 GO:0031418 L-ascorbic acid binding 7/1206 20/18639 0.35 5.40932835820896 0.00017119398464151 0.00575500886785139 GO:0042288 MHC class I protein binding 7/1206 20/18639 0.35 5.40932835820896 0.00017119398464151 0.00575500886785139 GO:0140311 protein sequestering activity 9/1206 33/18639 0.272727272727273 4.21506105834464 0.000180327045993553 0.00575500886785139 GO:0140416 transcription regulator inhibitor activity 9/1206 33/18639 0.272727272727273 4.21506105834464 0.000180327045993553 0.00575500886785139 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 20/1206 128/18639 0.15625 2.41487873134328 0.000207957208610826 0.00611228278229543 GO:0140658 ATP-dependent chromatin remodeler activity 23/1206 158/18639 0.145569620253165 2.24981107122615 0.000214302825452803 0.00611228278229543 GO:0032395 MHC class II receptor activity 5/1206 10/18639 0.5 7.72761194029851 0.000215360288695235 0.00611228278229543 GO:0001671 ATPase activator activity 8/1206 27/18639 0.296296296296296 4.57932559425097 0.00021981446793089 0.00611228278229543 GO:0005044 scavenger receptor activity 8/1206 27/18639 0.296296296296296 4.57932559425097 0.00021981446793089 0.00611228278229543 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 52/1206 484/18639 0.107438016528926 1.66047859874183 0.000224354157631256 0.00611228278229543 GO:0044389 ubiquitin-like protein ligase binding 38/1206 322/18639 0.118012422360248 1.82390840826921 0.000247254670767393 0.00641838341159232 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 15/1206 83/18639 0.180722891566265 2.79311274950548 0.000252953288763049 0.00641838341159232 GO:0045296 cadherin binding 39/1206 334/18639 0.116766467065868 1.80465189024935 0.000256600255224654 0.00641838341159232 GO:0003689 DNA clamp loader activity 23/1206 160/18639 0.14375 2.22168843283582 0.000258574085516253 0.00641838341159232 GO:0061980 regulatory RNA binding 12/1206 58/18639 0.206896551724138 3.19763252702007 0.000282566664007178 0.00642496352995431 GO:0000510 H3-H4 histone complex chaperone activity 22/1206 151/18639 0.145695364238411 2.25175447266976 0.000287599083704311 0.00642496352995431 GO:0140584 chromatin extrusion motor activity 22/1206 151/18639 0.145695364238411 2.25175447266976 0.000287599083704311 0.00642496352995431 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 22/1206 151/18639 0.145695364238411 2.25175447266976 0.000287599083704311 0.00642496352995431 GO:0140849 ATP-dependent H2AZ histone chaperone activity 22/1206 151/18639 0.145695364238411 2.25175447266976 0.000287599083704311 0.00642496352995431 GO:0015616 DNA translocase activity 22/1206 152/18639 0.144736842105263 2.23694029850746 0.00031615155799099 0.00669496312502045 GO:0140674 ATP-dependent histone chaperone activity 22/1206 152/18639 0.144736842105263 2.23694029850746 0.00031615155799099 0.00669496312502045 GO:0001216 DNA-binding transcription activator activity 52/1206 491/18639 0.105906313645621 1.6368057877618 0.000317666110676888 0.00669496312502045 GO:0061775 cohesin loader activity 22/1206 153/18639 0.143790849673203 2.22231977368062 0.000347159361829432 0.00718105568821252 GO:0003724 RNA helicase activity 14/1206 77/18639 0.181818181818182 2.81004070556309 0.000377058170005963 0.00765770865266656 GO:0051087 protein-folding chaperone binding 20/1206 134/18639 0.149253731343284 2.30674983292493 0.000387068435776487 0.00770919635980327 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 12/1206 60/18639 0.2 3.0910447761194 0.00039339677037492 0.00770919635980327 GO:0004386 helicase activity 22/1206 155/18639 0.141935483870968 2.19364467982667 0.000417253737737465 0.00803573146642669 GO:0009055 electron transfer activity 18/1206 116/18639 0.155172413793103 2.39822439526505 0.000461178423592917 0.00873112371446251 GO:0035925 mRNA 3'-UTR AU-rich region binding 8/1206 30/18639 0.266666666666667 4.12139303482587 0.000487102108325202 0.00906821758332085 GO:0008094 ATP-dependent activity, acting on DNA 27/1206 210/18639 0.128571428571429 1.98710021321962 0.00050106711473763 0.00917527815019562 GO:0016887 ATP hydrolysis activity 45/1206 417/18639 0.107913669064748 1.66782991517234 0.000525401865124253 0.00946570779586758 GO:0001618 virus receptor activity 14/1206 81/18639 0.172839506172839 2.67127326331306 0.000643012984587184 0.0101161338561111 GO:0033192 calmodulin-dependent protein phosphatase activity 14/1206 81/18639 0.172839506172839 2.67127326331306 0.000643012984587184 0.0101161338561111 GO:0140791 histone H2AXS140 phosphatase activity 14/1206 81/18639 0.172839506172839 2.67127326331306 0.000643012984587184 0.0101161338561111 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 14/1206 81/18639 0.172839506172839 2.67127326331306 0.000643012984587184 0.0101161338561111 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 14/1206 81/18639 0.172839506172839 2.67127326331306 0.000643012984587184 0.0101161338561111 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 14/1206 81/18639 0.172839506172839 2.67127326331306 0.000643012984587184 0.0101161338561111 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 14/1206 81/18639 0.172839506172839 2.67127326331306 0.000643012984587184 0.0101161338561111 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 14/1206 81/18639 0.172839506172839 2.67127326331306 0.000643012984587184 0.0101161338561111 GO:1990439 MAP kinase serine/threonine phosphatase activity 14/1206 81/18639 0.172839506172839 2.67127326331306 0.000643012984587184 0.0101161338561111 GO:0003746 translation elongation factor activity 6/1206 18/18639 0.333333333333333 5.15174129353234 0.000684329499225733 0.010616611814377 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 14/1206 82/18639 0.170731707317073 2.63869676010193 0.000730062158440079 0.0108730590797009 GO:0033549 MAP kinase phosphatase activity 14/1206 82/18639 0.170731707317073 2.63869676010193 0.000730062158440079 0.0108730590797009 GO:0140272 exogenous protein binding 14/1206 82/18639 0.170731707317073 2.63869676010193 0.000730062158440079 0.0108730590797009 GO:0008135 translation factor activity, RNA binding 14/1206 83/18639 0.168674698795181 2.60690523287179 0.000826866856635418 0.0121527668271285 GO:0017018 myosin phosphatase activity 14/1206 84/18639 0.166666666666667 2.57587064676617 0.000934276160284223 0.0133793137312497 GO:0180051 translation factor activity 14/1206 84/18639 0.166666666666667 2.57587064676617 0.000934276160284223 0.0133793137312497 GO:0008137 NADH dehydrogenase (ubiquinone) activity 9/1206 41/18639 0.219512195121951 3.39261012013105 0.00102619479593554 0.0144033791954317 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 7/1206 26/18639 0.269230769230769 4.16102181400689 0.00103157594953853 0.0144033791954317 GO:0032813 tumor necrosis factor receptor superfamily binding 10/1206 50/18639 0.2 3.0910447761194 0.001180787384248 0.0160873837012677 GO:0003712 transcription coregulator activity 50/1206 495/18639 0.101010101010101 1.56113372531283 0.00118098967189252 0.0160873837012677 GO:0016853 isomerase activity 23/1206 180/18639 0.127777777777778 1.97483416252073 0.00137132122271364 0.018455009708086 GO:0004857 enzyme inhibitor activity 43/1206 416/18639 0.103365384615385 1.59753516073479 0.00162585621002946 0.0216200165071775 GO:0003954 NADH dehydrogenase activity 9/1206 44/18639 0.204545454545455 3.16129579375848 0.00174385789234126 0.0229163443028846 GO:0003697 single-stranded DNA binding 17/1206 121/18639 0.140495867768595 2.17139509066239 0.00201741129496007 0.0262028885636093 GO:0043394 proteoglycan binding 8/1206 37/18639 0.216216216216216 3.34167002823719 0.00214644208438533 0.0275583426236599 GO:0061133 endopeptidase activator activity 6/1206 22/18639 0.272727272727273 4.21506105834464 0.00220032856314278 0.0279291705117101 GO:0019955 cytokine binding 19/1206 144/18639 0.131944444444444 2.03923092868988 0.00238469245761622 0.0299292300579474 GO:0004722 protein serine/threonine phosphatase activity 15/1206 103/18639 0.145631067961165 2.25076075931024 0.00253517924339534 0.0312323545381221 GO:0001968 fibronectin binding 7/1206 30/18639 0.233333333333333 3.60621890547264 0.00254444428197772 0.0312323545381221 GO:0051880 G-quadruplex DNA binding 4/1206 10/18639 0.4 6.18208955223881 0.00267078957300125 0.0323283142301774 GO:0031435 mitogen-activated protein kinase kinase kinase binding 5/1206 16/18639 0.3125 4.82975746268657 0.00269161434503715 0.0323283142301774 GO:0004860 protein kinase inhibitor activity 13/1206 84/18639 0.154761904761905 2.39187988628287 0.00278374560171308 0.0330791897565267 GO:0003725 double-stranded RNA binding 12/1206 75/18639 0.16 2.47283582089552 0.00300672641065263 0.0353527726389367 GO:0005164 tumor necrosis factor receptor binding 7/1206 31/18639 0.225806451612903 3.48988926336062 0.0031058399567924 0.0361377419972615 GO:0016504 peptidase activator activity 10/1206 57/18639 0.175438596491228 2.71144278606965 0.00329365330578576 0.0379279457996154 GO:0048027 mRNA 5'-UTR binding 6/1206 24/18639 0.25 3.86380597014925 0.00355184435596134 0.0404837769960084 GO:1990226 histone methyltransferase binding 5/1206 17/18639 0.294117647058824 4.54565408252853 0.00361208247307401 0.0407545062871078 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 10/1206 58/18639 0.172413793103448 2.66469377251673 0.00375399110093297 0.0419320805974213 GO:0022853 active monoatomic ion transmembrane transporter activity 16/1206 118/18639 0.135593220338983 2.0956235770301 0.0038637163449274 0.0427304074978605 GO:0042608 T cell receptor binding 4/1206 11/18639 0.363636363636364 5.62008141112619 0.00398335956410886 0.0436216924814666 GO:1990841 promoter-specific chromatin binding 11/1206 68/18639 0.161764705882353 2.50010974539069 0.00404567925972326 0.0438740168263193 GO:0004725 protein tyrosine phosphatase activity 14/1206 98/18639 0.142857142857143 2.20788912579957 0.00414750042242966 0.0445457497293647 GO:0030695 GTPase regulator activity 47/1206 489/18639 0.0961145194274029 1.4854714159265 0.00430587835906745 0.0458063440674128 GO:0060589 nucleoside-triphosphatase regulator activity 47/1206 490/18639 0.0959183673469388 1.48243984160829 0.00447360490140959 0.0471416667440992 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 13/1206 89/18639 0.146067415730337 2.2575046117726 0.00464398611385693 0.0480308563812795 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 13/1206 89/18639 0.146067415730337 2.2575046117726 0.00464398611385693 0.0480308563812795 GO:0030228 lipoprotein particle receptor activity 5/1206 18/18639 0.277777777777778 4.29311774461028 0.00473814130916952 0.0481136712940214 GO:0034185 apolipoprotein binding 5/1206 18/18639 0.277777777777778 4.29311774461028 0.00473814130916952 0.0481136712940214 GO:0097110 scaffold protein binding 11/1206 70/18639 0.157142857142857 2.42867803837953 0.00507709287867637 0.0505596416585163 GO:0019210 kinase inhibitor activity 13/1206 90/18639 0.144444444444444 2.23242122719735 0.0051148070791516 0.0505596416585163 GO:0140793 histone H2AXY142 phosphatase activity 13/1206 90/18639 0.144444444444444 2.23242122719735 0.0051148070791516 0.0505596416585163 GO:0033218 amide binding 27/1206 247/18639 0.109311740890688 1.6894374282434 0.00533412388118248 0.0517507600149604 GO:0015399 primary active transmembrane transporter activity 20/1206 166/18639 0.120481927710843 1.86207516633699 0.00534911953079469 0.0517507600149604 GO:0005096 GTPase activator activity 29/1206 271/18639 0.107011070110701 1.65388004626315 0.0053742955789932 0.0517507600149604 GO:0031543 peptidyl-proline dioxygenase activity 4/1206 12/18639 0.333333333333333 5.15174129353234 0.00567168688934137 0.0536706277418104 GO:0005080 protein kinase C binding 9/1206 52/18639 0.173076923076923 2.67494259471871 0.00569371736113261 0.0536706277418104 GO:0048156 tau protein binding 8/1206 43/18639 0.186046511627907 2.8753904894134 0.00571781978628061 0.0536706277418104 GO:0003714 transcription corepressor activity 23/1206 204/18639 0.112745098039216 1.74250073163594 0.00669576609038025 0.0622840472145364 GO:0051213 dioxygenase activity 13/1206 93/18639 0.139784946236559 2.16040763922324 0.00676050823757194 0.0622840472145364 GO:0140789 histone phosphatase activity 17/1206 136/18639 0.125 1.93190298507463 0.00680273389451517 0.0622840472145364 GO:0017069 snRNA binding 9/1206 54/18639 0.166666666666667 2.57587064676617 0.00733356633859505 0.0665983219529323 GO:0005539 glycosaminoglycan binding 26/1206 242/18639 0.107438016528926 1.66047859874183 0.0076926829032743 0.0678710697367696 GO:0016004 phospholipase activator activity 5/1206 20/18639 0.25 3.86380597014925 0.00769748484653339 0.0678710697367696 GO:0048029 monosaccharide binding 11/1206 74/18639 0.148648648648649 2.29739814441307 0.00775674848837409 0.0678710697367696 GO:0005172 vascular endothelial growth factor receptor binding 4/1206 13/18639 0.307692307692308 4.75545350172216 0.00777752634405238 0.0678710697367696 GO:0008035 high-density lipoprotein particle binding 4/1206 13/18639 0.307692307692308 4.75545350172216 0.00777752634405238 0.0678710697367696 GO:0008201 heparin binding 20/1206 172/18639 0.116279069767442 1.79711905588337 0.00789013867469509 0.0683200379816622 GO:0097718 disordered domain specific binding 6/1206 28/18639 0.214285714285714 3.31183368869936 0.00796883186877623 0.0684706553647926 GO:0030291 protein serine/threonine kinase inhibitor activity 8/1206 46/18639 0.173913043478261 2.68786502271252 0.00867198352834644 0.0739435542073509 GO:0004629 phospholipase C activity 6/1206 29/18639 0.206896551724138 3.19763252702007 0.00950911902372859 0.080467317799279 GO:0140097 catalytic activity, acting on DNA 33/1206 336/18639 0.0982142857142857 1.51792377398721 0.0111393229512589 0.0926170045091494 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 8/1206 48/18639 0.166666666666667 2.57587064676617 0.0111936397571488 0.0926170045091494 GO:0140693 molecular condensate scaffold activity 8/1206 48/18639 0.166666666666667 2.57587064676617 0.0111936397571488 0.0926170045091494 GO:0061134 peptidase regulator activity 24/1206 226/18639 0.106194690265487 1.64126271298375 0.0116247542310287 0.0954768417357281 GO:0036002 pre-mRNA binding 9/1206 59/18639 0.152542372881356 2.35757652415887 0.0130005945337101 0.105229449957639 GO:0070063 RNA polymerase binding 9/1206 59/18639 0.152542372881356 2.35757652415887 0.0130005945337101 0.105229449957639 GO:0004129 cytochrome-c oxidase activity 4/1206 15/18639 0.266666666666667 4.12139303482587 0.0133874616506302 0.105308413125028 GO:0005041 low-density lipoprotein particle receptor activity 4/1206 15/18639 0.266666666666667 4.12139303482587 0.0133874616506302 0.105308413125028 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/1206 15/18639 0.266666666666667 4.12139303482587 0.0133874616506302 0.105308413125028 GO:0140776 protein-containing complex destabilizing activity 4/1206 15/18639 0.266666666666667 4.12139303482587 0.0133874616506302 0.105308413125028 GO:0001530 lipopolysaccharide binding 7/1206 41/18639 0.170731707317073 2.63869676010193 0.0151418514667567 0.118103331826603 GO:0003713 transcription coactivator activity 26/1206 256/18639 0.1015625 1.56967117537313 0.0152254966723642 0.118103331826603 GO:0016922 nuclear receptor binding 16/1206 137/18639 0.116788321167883 1.8049896502887 0.0157047647119129 0.120725276706824 GO:0061135 endopeptidase regulator activity 20/1206 184/18639 0.108695652173913 1.67991563919533 0.0158801654990044 0.120725276706824 GO:0030544 Hsp70 protein binding 8/1206 51/18639 0.156862745098039 2.42434884401522 0.0159358042174155 0.120725276706824 GO:0015026 coreceptor activity 9/1206 61/18639 0.147540983606557 2.28027893320284 0.0160001948711647 0.120725276706824 GO:0001221 transcription coregulator binding 14/1206 115/18639 0.121739130434783 1.88150551589877 0.0164561281354962 0.120725276706824 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/1206 16/18639 0.25 3.86380597014925 0.0169527440858279 0.120725276706824 GO:0017070 U6 snRNA binding 4/1206 16/18639 0.25 3.86380597014925 0.0169527440858279 0.120725276706824 GO:0015149 hexose transmembrane transporter activity 5/1206 24/18639 0.208333333333333 3.21983830845771 0.0170309385328523 0.120725276706824 GO:0019957 C-C chemokine binding 5/1206 24/18639 0.208333333333333 3.21983830845771 0.0170309385328523 0.120725276706824 GO:0035035 histone acetyltransferase binding 5/1206 24/18639 0.208333333333333 3.21983830845771 0.0170309385328523 0.120725276706824 GO:0055056 D-glucose transmembrane transporter activity 5/1206 24/18639 0.208333333333333 3.21983830845771 0.0170309385328523 0.120725276706824 GO:0060229 lipase activator activity 5/1206 24/18639 0.208333333333333 3.21983830845771 0.0170309385328523 0.120725276706824 GO:0070300 phosphatidic acid binding 5/1206 24/18639 0.208333333333333 3.21983830845771 0.0170309385328523 0.120725276706824 GO:0005518 collagen binding 10/1206 72/18639 0.138888888888889 2.14655887230514 0.0171122141796128 0.120725276706824 GO:0042056 chemoattractant activity 7/1206 42/18639 0.166666666666667 2.57587064676617 0.0171847081435855 0.120725276706824 GO:0001540 amyloid-beta binding 11/1206 83/18639 0.132530120481928 2.04828268297069 0.0177171821464096 0.123603875006587 GO:0030295 protein kinase activator activity 16/1206 139/18639 0.115107913669065 1.77901857618383 0.0178157778657659 0.123603875006587 GO:0004721 phosphoprotein phosphatase activity 19/1206 175/18639 0.108571428571429 1.67799573560768 0.0186070460689627 0.128296731228588 GO:0016860 intramolecular oxidoreductase activity 8/1206 53/18639 0.150943396226415 2.33286398197691 0.0198111785649215 0.134933454006203 GO:0140296 general transcription initiation factor binding 8/1206 53/18639 0.150943396226415 2.33286398197691 0.0198111785649215 0.134933454006203 GO:0016831 carboxy-lyase activity 6/1206 34/18639 0.176470588235294 2.72739244951712 0.020467901568523 0.137726783446025 GO:0090482 vitamin transmembrane transporter activity 6/1206 34/18639 0.176470588235294 2.72739244951712 0.020467901568523 0.137726783446025 GO:0005525 GTP binding 35/1206 378/18639 0.0925925925925926 1.43103924820343 0.020906246847216 0.139179277631357 GO:0005092 GDP-dissociation inhibitor activity 4/1206 17/18639 0.235294117647059 3.63652326602283 0.0210575630435983 0.139179277631357 GO:0008429 phosphatidylethanolamine binding 4/1206 17/18639 0.235294117647059 3.63652326602283 0.0210575630435983 0.139179277631357 GO:0031720 haptoglobin binding 3/1206 10/18639 0.3 4.6365671641791 0.0229965305242427 0.151100732915171 GO:0004435 phosphatidylinositol phospholipase C activity 5/1206 26/18639 0.192307692307692 2.97215843857635 0.0236939780586325 0.152104445353405 GO:0008143 poly(A) binding 5/1206 26/18639 0.192307692307692 2.97215843857635 0.0236939780586325 0.152104445353405 GO:0008198 ferrous iron binding 5/1206 26/18639 0.192307692307692 2.97215843857635 0.0236939780586325 0.152104445353405 GO:0015145 monosaccharide transmembrane transporter activity 5/1206 26/18639 0.192307692307692 2.97215843857635 0.0236939780586325 0.152104445353405 GO:0008009 chemokine activity 7/1206 45/18639 0.155555555555556 2.40414593698176 0.0244644897732963 0.15615334329584 GO:0050811 GABA receptor binding 4/1206 18/18639 0.222222222222222 3.43449419568823 0.0257202549677209 0.163235936357638 GO:0016651 oxidoreductase activity, acting on NAD(P)H 11/1206 88/18639 0.125 1.93190298507463 0.0262828003137965 0.165863773731699 GO:0035255 ionotropic glutamate receptor binding 5/1206 27/18639 0.185185185185185 2.86207849640685 0.0275752472826822 0.173042422554809 GO:0019001 guanyl nucleotide binding 36/1206 400/18639 0.09 1.39097014925373 0.0282982162758942 0.174664675372271 GO:0032561 guanyl ribonucleotide binding 36/1206 400/18639 0.09 1.39097014925373 0.0282982162758942 0.174664675372271 GO:0003727 single-stranded RNA binding 11/1206 89/18639 0.123595505617978 1.91019620996143 0.0283028704049965 0.174664675372271 GO:0019838 growth factor binding 15/1206 136/18639 0.110294117647059 1.7046202809482 0.0299519318086246 0.1799532972273 GO:0005125 cytokine activity 23/1206 234/18639 0.0982905982905983 1.51910320193902 0.0300110261012322 0.1799532972273 GO:0019209 kinase activator activity 16/1206 148/18639 0.108108108108108 1.6708350141186 0.0301073761864792 0.1799532972273 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/1206 11/18639 0.272727272727273 4.21506105834464 0.0301264696342929 0.1799532972273 GO:0008432 JUN kinase binding 3/1206 11/18639 0.272727272727273 4.21506105834464 0.0301264696342929 0.1799532972273 GO:0140031 phosphorylation-dependent protein binding 3/1206 11/18639 0.272727272727273 4.21506105834464 0.0301264696342929 0.1799532972273 GO:0042393 histone binding 24/1206 247/18639 0.097165991902834 1.50172215843858 0.030510669311708 0.181278817133925 GO:0046332 SMAD binding 10/1206 79/18639 0.126582278481013 1.95635745324013 0.0307369355012564 0.181656915105309 GO:0008301 DNA binding, bending 4/1206 19/18639 0.210526315789474 3.25373134328358 0.0309543088182954 0.181978752368611 GO:0051119 sugar transmembrane transporter activity 5/1206 28/18639 0.178571428571429 2.75986140724947 0.0318375115030965 0.186191101303449 GO:1901681 sulfur compound binding 26/1206 275/18639 0.0945454545454545 1.46122116689281 0.0337356831123018 0.195602199658506 GO:0043531 ADP binding 6/1206 38/18639 0.157894736842105 2.44029850746269 0.0337969780967696 0.195602199658506 GO:0031406 carboxylic acid binding 19/1206 187/18639 0.101604278074866 1.57031686487349 0.0341292226121816 0.196506915761891 GO:0042826 histone deacetylase binding 14/1206 127/18639 0.110236220472441 1.70372546715243 0.0352778108218773 0.202078536861728 GO:0043177 organic acid binding 19/1206 189/18639 0.100529100529101 1.55369975519229 0.0374454755638846 0.2134010010452 GO:0035259 nuclear glucocorticoid receptor binding 3/1206 12/18639 0.25 3.86380597014925 0.03827806388261 0.217038565263327 GO:0048020 CCR chemokine receptor binding 7/1206 50/18639 0.14 2.16373134328358 0.0408428228747393 0.230411278540827 GO:0001965 G-protein alpha-subunit binding 5/1206 30/18639 0.166666666666667 2.57587064676617 0.0415370543817245 0.233150199720534 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/1206 21/18639 0.19047619047619 2.94385216773276 0.0431671667751719 0.239889180536652 GO:0070182 DNA polymerase binding 4/1206 21/18639 0.19047619047619 2.94385216773276 0.0431671667751719 0.239889180536652 GO:0016830 carbon-carbon lyase activity 7/1206 51/18639 0.137254901960784 2.12130523851332 0.0448053031156771 0.247760017723819 GO:0004896 cytokine receptor activity 11/1206 96/18639 0.114583333333333 1.77091106965174 0.0456435014678703 0.248719847352329 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 18/1206 181/18639 0.0994475138121547 1.53698359033561 0.0458629217861832 0.248719847352329 GO:0032182 ubiquitin-like protein binding 13/1206 120/18639 0.108333333333333 1.67431592039801 0.0466332779215253 0.248719847352329 GO:0042578 phosphoric ester hydrolase activity 32/1206 363/18639 0.0881542699724518 1.36244397845483 0.0468393220125004 0.248719847352329 GO:0016411 acylglycerol O-acyltransferase activity 5/1206 31/18639 0.161290322580645 2.49277804525758 0.0469855349994146 0.248719847352329 GO:0070325 lipoprotein particle receptor binding 5/1206 31/18639 0.161290322580645 2.49277804525758 0.0469855349994146 0.248719847352329 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/1206 13/18639 0.230769230769231 3.56659012629162 0.0474282251441773 0.248719847352329 GO:0017154 semaphorin receptor activity 3/1206 13/18639 0.230769230769231 3.56659012629162 0.0474282251441773 0.248719847352329 GO:0032396 inhibitory MHC class I receptor activity 3/1206 13/18639 0.230769230769231 3.56659012629162 0.0474282251441773 0.248719847352329 GO:0071837 HMG box domain binding 3/1206 13/18639 0.230769230769231 3.56659012629162 0.0474282251441773 0.248719847352329 GO:0097157 pre-mRNA intronic binding 3/1206 13/18639 0.230769230769231 3.56659012629162 0.0474282251441773 0.248719847352329 GO:0070034 telomerase RNA binding 4/1206 22/18639 0.181818181818182 2.81004070556309 0.050150305478106 0.261765846817964 GO:0016791 phosphatase activity 25/1206 273/18639 0.0915750915750916 1.41531354217921 0.0504466199345263 0.262087788217981 GO:0051015 actin filament binding 20/1206 209/18639 0.0956937799043062 1.47896879240163 0.0515092188649667 0.265103355745296 GO:0008307 structural constituent of muscle 6/1206 42/18639 0.142857142857143 2.20788912579957 0.0517390613719558 0.265103355745296 GO:0043175 RNA polymerase core enzyme binding 6/1206 42/18639 0.142857142857143 2.20788912579957 0.0517390613719558 0.265103355745296 GO:0030515 snoRNA binding 5/1206 32/18639 0.15625 2.41487873134328 0.0528374441055659 0.268270113935987 GO:0070717 poly-purine tract binding 5/1206 32/18639 0.15625 2.41487873134328 0.0528374441055659 0.268270113935987 GO:0015078 proton transmembrane transporter activity 18/1206 185/18639 0.0972972972972973 1.50375151270674 0.0546405556239707 0.275497988042336 GO:0140030 modification-dependent protein binding 17/1206 173/18639 0.0982658959537572 1.51872142179277 0.0561444273587674 0.275497988042336 GO:0004712 protein serine/threonine/tyrosine kinase activity 6/1206 43/18639 0.13953488372093 2.15654286706005 0.0569809014517765 0.275497988042336 GO:0002020 protease binding 14/1206 136/18639 0.102941176470588 1.59097892888499 0.0571429731213162 0.275497988042336 GO:0005161 platelet-derived growth factor receptor binding 3/1206 14/18639 0.214285714285714 3.31183368869936 0.0575436179752333 0.275497988042336 GO:0005344 oxygen carrier activity 3/1206 14/18639 0.214285714285714 3.31183368869936 0.0575436179752333 0.275497988042336 GO:0008191 metalloendopeptidase inhibitor activity 3/1206 14/18639 0.214285714285714 3.31183368869936 0.0575436179752333 0.275497988042336 GO:0070742 C2H2 zinc finger domain binding 3/1206 14/18639 0.214285714285714 3.31183368869936 0.0575436179752333 0.275497988042336 GO:0098847 sequence-specific single stranded DNA binding 3/1206 14/18639 0.214285714285714 3.31183368869936 0.0575436179752333 0.275497988042336 GO:0019843 rRNA binding 8/1206 65/18639 0.123076923076923 1.90218140068886 0.0576067821096439 0.275497988042336 GO:0008171 O-methyltransferase activity 4/1206 23/18639 0.173913043478261 2.68786502271252 0.0577139921234616 0.275497988042336 GO:0016493 C-C chemokine receptor activity 4/1206 23/18639 0.173913043478261 2.68786502271252 0.0577139921234616 0.275497988042336 GO:0042171 lysophosphatidic acid acyltransferase activity 4/1206 23/18639 0.173913043478261 2.68786502271252 0.0577139921234616 0.275497988042336 GO:0071617 lysophospholipid acyltransferase activity 4/1206 23/18639 0.173913043478261 2.68786502271252 0.0577139921234616 0.275497988042336 GO:0019956 chemokine binding 5/1206 33/18639 0.151515151515152 2.34170058796924 0.0590936659515174 0.279693325711207 GO:0030296 protein tyrosine kinase activator activity 5/1206 33/18639 0.151515151515152 2.34170058796924 0.0590936659515174 0.279693325711207 GO:0003924 GTPase activity 29/1206 331/18639 0.0876132930513595 1.35408305902512 0.0598638577095096 0.28214316059714 GO:0003735 structural constituent of ribosome 17/1206 175/18639 0.0971428571428571 1.50136460554371 0.0612308404205171 0.287373314074444 GO:0001046 core promoter sequence-specific DNA binding 6/1206 44/18639 0.136363636363636 2.10753052917232 0.0625296939923739 0.292241289495739 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/1206 24/18639 0.166666666666667 2.57587064676617 0.0658506028415834 0.306479680725203 GO:0050840 extracellular matrix binding 8/1206 67/18639 0.119402985074627 1.84539986633994 0.0666207479888511 0.308777491715961 GO:0000774 adenyl-nucleotide exchange factor activity 3/1206 15/18639 0.2 3.0910447761194 0.068582657056384 0.313962409557299 GO:0048531 beta-1,3-galactosyltransferase activity 3/1206 15/18639 0.2 3.0910447761194 0.068582657056384 0.313962409557299 GO:0120283 protein serine/threonine kinase binding 3/1206 15/18639 0.2 3.0910447761194 0.068582657056384 0.313962409557299 GO:0000287 magnesium ion binding 21/1206 230/18639 0.091304347826087 1.41112913692408 0.0700659923300424 0.319443728296561 GO:0004601 peroxidase activity 7/1206 57/18639 0.12280701754386 1.89800995024876 0.0736739207332582 0.334527518126217 GO:0120020 cholesterol transfer activity 4/1206 25/18639 0.16 2.47283582089552 0.0745491364318313 0.337131114956905 GO:0019208 phosphatase regulator activity 12/1206 117/18639 0.102564102564103 1.58515116724072 0.0758655898700218 0.341701064051671 GO:0002039 p53 binding 8/1206 69/18639 0.115942028985507 1.79191001514168 0.0764572500776723 0.342982925047229 GO:0061630 ubiquitin protein ligase activity 30/1206 353/18639 0.084985835694051 1.31347511733119 0.0769067379430105 0.343619305129371 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/1206 36/18639 0.138888888888889 2.14655887230514 0.0802703915274166 0.351232151887045 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/1206 36/18639 0.138888888888889 2.14655887230514 0.0802703915274166 0.351232151887045 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/1206 36/18639 0.138888888888889 2.14655887230514 0.0802703915274166 0.351232151887045 GO:0005159 insulin-like growth factor receptor binding 3/1206 16/18639 0.1875 2.89785447761194 0.0804972523572816 0.351232151887045 GO:0055102 lipase inhibitor activity 3/1206 16/18639 0.1875 2.89785447761194 0.0804972523572816 0.351232151887045 GO:0097027 ubiquitin-protein transferase activator activity 3/1206 16/18639 0.1875 2.89785447761194 0.0804972523572816 0.351232151887045 GO:0019903 protein phosphatase binding 14/1206 144/18639 0.0972222222222222 1.5025912106136 0.0830815839345321 0.355892037035478 GO:0001637 G protein-coupled chemoattractant receptor activity 4/1206 26/18639 0.153846153846154 2.37772675086108 0.083795528863322 0.355892037035478 GO:0004950 chemokine receptor activity 4/1206 26/18639 0.153846153846154 2.37772675086108 0.083795528863322 0.355892037035478 GO:0008157 protein phosphatase 1 binding 4/1206 26/18639 0.153846153846154 2.37772675086108 0.083795528863322 0.355892037035478 GO:0050750 low-density lipoprotein particle receptor binding 4/1206 26/18639 0.153846153846154 2.37772675086108 0.083795528863322 0.355892037035478 GO:0070412 R-SMAD binding 4/1206 26/18639 0.153846153846154 2.37772675086108 0.083795528863322 0.355892037035478 GO:0097602 cullin family protein binding 4/1206 26/18639 0.153846153846154 2.37772675086108 0.083795528863322 0.355892037035478 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/1206 59/18639 0.11864406779661 1.83367062990134 0.0852671806504784 0.360770609040092 GO:0140299 molecular sensor activity 8/1206 71/18639 0.112676056338028 1.74143367668699 0.0871189842781207 0.36721473750438 GO:0061659 ubiquitin-like protein ligase activity 31/1206 372/18639 0.0833333333333333 1.28793532338308 0.0889376674487258 0.373471332857995 GO:0001098 basal transcription machinery binding 7/1206 60/18639 0.116666666666667 1.80310945273632 0.0914318586978859 0.380076387372317 GO:0001099 basal RNA polymerase II transcription machinery binding 7/1206 60/18639 0.116666666666667 1.80310945273632 0.0914318586978859 0.380076387372317 GO:0140098 catalytic activity, acting on RNA 32/1206 387/18639 0.082687338501292 1.27795132862818 0.0919249735022011 0.380076387372317 GO:0051117 ATPase binding 9/1206 84/18639 0.107142857142857 1.65591684434968 0.092636545340413 0.380076387372317 GO:0042379 chemokine receptor binding 8/1206 72/18639 0.111111111111111 1.71724709784411 0.0927583031019089 0.380076387372317 GO:0004549 tRNA-specific ribonuclease activity 3/1206 17/18639 0.176470588235294 2.72739244951712 0.0932343286387851 0.380076387372317 GO:0016018 cyclosporin A binding 3/1206 17/18639 0.176470588235294 2.72739244951712 0.0932343286387851 0.380076387372317 GO:0070403 NAD+ binding 3/1206 17/18639 0.176470588235294 2.72739244951712 0.0932343286387851 0.380076387372317 GO:0005385 zinc ion transmembrane transporter activity 4/1206 27/18639 0.148148148148148 2.28966279712548 0.0935729691382159 0.380076387372317 GO:0042162 telomeric DNA binding 5/1206 38/18639 0.131578947368421 2.03358208955224 0.0963480764508644 0.389930439839187 GO:0030246 carbohydrate binding 24/1206 280/18639 0.0857142857142857 1.32473347547974 0.0972810017421117 0.392284761537685 GO:0043539 protein serine/threonine kinase activator activity 8/1206 73/18639 0.10958904109589 1.69372316499693 0.0986018813800178 0.396180940652805 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 23/1206 268/18639 0.0858208955223881 1.32638115393183 0.101724321071959 0.407261887589168 GO:0046966 nuclear thyroid hormone receptor binding 4/1206 28/18639 0.142857142857143 2.20788912579957 0.103862212077402 0.409943784065224 GO:0051019 mitogen-activated protein kinase binding 4/1206 28/18639 0.142857142857143 2.20788912579957 0.103862212077402 0.409943784065224 GO:0051537 2 iron, 2 sulfur cluster binding 4/1206 28/18639 0.142857142857143 2.20788912579957 0.103862212077402 0.409943784065224 GO:0141052 histone H3 demethylase activity 4/1206 28/18639 0.142857142857143 2.20788912579957 0.103862212077402 0.409943784065224 GO:0000217 DNA secondary structure binding 5/1206 39/18639 0.128205128205128 1.9814389590509 0.104952840832296 0.411341484946227 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 5/1206 39/18639 0.128205128205128 1.9814389590509 0.104952840832296 0.411341484946227 GO:0015172 acidic amino acid transmembrane transporter activity 3/1206 18/18639 0.166666666666667 2.57587064676617 0.106737143372998 0.413977045651524 GO:0031690 adrenergic receptor binding 3/1206 18/18639 0.166666666666667 2.57587064676617 0.106737143372998 0.413977045651524 GO:0032393 MHC class I receptor activity 3/1206 18/18639 0.166666666666667 2.57587064676617 0.106737143372998 0.413977045651524 GO:0004842 ubiquitin-protein transferase activity 36/1206 449/18639 0.0801781737193764 1.23917162517036 0.107572095719689 0.415771733283367 GO:0005200 structural constituent of cytoskeleton 11/1206 112/18639 0.0982142857142857 1.51792377398721 0.109033006681021 0.419965063664486 GO:0003743 translation initiation factor activity 6/1206 51/18639 0.117647058823529 1.81826163301141 0.109880895974809 0.42177649760777 GO:0043021 ribonucleoprotein complex binding 16/1206 177/18639 0.0903954802259887 1.39708238468674 0.110277076788896 0.421847584839714 GO:0043130 ubiquitin binding 10/1206 100/18639 0.1 1.5455223880597 0.112264185189784 0.427137109843171 GO:0019787 ubiquitin-like protein transferase activity 38/1206 479/18639 0.0793319415448852 1.22609291745864 0.112424628732222 0.427137109843171 GO:0015144 carbohydrate transmembrane transporter activity 5/1206 40/18639 0.125 1.93190298507463 0.11392190000807 0.428453745148194 GO:0032451 demethylase activity 5/1206 40/18639 0.125 1.93190298507463 0.11392190000807 0.428453745148194 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/1206 40/18639 0.125 1.93190298507463 0.11392190000807 0.428453745148194 GO:0051861 glycolipid binding 4/1206 29/18639 0.137931034482759 2.13175501801338 0.114641884419979 0.429714714419854 GO:0098631 cell adhesion mediator activity 8/1206 76/18639 0.105263157894737 1.62686567164179 0.117340740232563 0.438359889096232 GO:0016755 aminoacyltransferase activity 39/1206 496/18639 0.0786290322580645 1.21522929706307 0.119606380183312 0.444398541314768 GO:0015245 fatty acid transmembrane transporter activity 3/1206 19/18639 0.157894736842105 2.44029850746269 0.120946424852005 0.444398541314768 GO:0043395 heparan sulfate proteoglycan binding 3/1206 19/18639 0.157894736842105 2.44029850746269 0.120946424852005 0.444398541314768 GO:0046624 sphingolipid transporter activity 3/1206 19/18639 0.157894736842105 2.44029850746269 0.120946424852005 0.444398541314768 GO:0097001 ceramide binding 3/1206 19/18639 0.157894736842105 2.44029850746269 0.120946424852005 0.444398541314768 GO:0001727 lipid kinase activity 5/1206 41/18639 0.121951219512195 1.88478340007281 0.123244007620791 0.449880903635371 GO:0042169 SH2 domain binding 5/1206 41/18639 0.121951219512195 1.88478340007281 0.123244007620791 0.449880903635371 GO:0031490 chromatin DNA binding 12/1206 128/18639 0.09375 1.44892723880597 0.1252804553173 0.45268571043691 GO:0008187 poly-pyrimidine tract binding 4/1206 30/18639 0.133333333333333 2.06069651741294 0.125888781348941 0.45268571043691 GO:0032452 histone demethylase activity 4/1206 30/18639 0.133333333333333 2.06069651741294 0.125888781348941 0.45268571043691 GO:0048019 receptor antagonist activity 4/1206 30/18639 0.133333333333333 2.06069651741294 0.125888781348941 0.45268571043691 GO:0005246 calcium channel regulator activity 6/1206 53/18639 0.113207547169811 1.74964798648268 0.126038725108217 0.45268571043691 GO:0005201 extracellular matrix structural constituent 15/1206 168/18639 0.0892857142857143 1.37993070362473 0.128269375502674 0.455391556861668 GO:0035591 signaling adaptor activity 12/1206 129/18639 0.0930232558139535 1.4376952447067 0.130503777464708 0.455391556861668 GO:0016859 cis-trans isomerase activity 5/1206 42/18639 0.119047619047619 1.83990760483298 0.132906838194958 0.455391556861668 GO:0048487 beta-tubulin binding 5/1206 42/18639 0.119047619047619 1.83990760483298 0.132906838194958 0.455391556861668 GO:0001094 TFIID-class transcription factor complex binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0005031 tumor necrosis factor receptor activity 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0005528 FK506 binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0008190 eukaryotic initiation factor 4E binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0031434 mitogen-activated protein kinase kinase binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0031996 thioesterase binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0043295 glutathione binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0043422 protein kinase B binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0070513 death domain binding 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0141109 transporter activator activity 2/1206 10/18639 0.2 3.0910447761194 0.133315164810891 0.455391556861668 GO:0140463 chromatin-protein adaptor activity 6/1206 54/18639 0.111111111111111 1.71724709784411 0.134526575877967 0.458128613584419 GO:0001217 DNA-binding transcription repressor activity 23/1206 278/18639 0.0827338129496403 1.27866960163213 0.134971546170855 0.458246860403785 GO:0000339 RNA cap binding 3/1206 20/18639 0.15 2.31828358208955 0.135801350153317 0.458278272269653 GO:0043024 ribosomal small subunit binding 3/1206 20/18639 0.15 2.31828358208955 0.135801350153317 0.458278272269653 GO:0070273 phosphatidylinositol-4-phosphate binding 4/1206 31/18639 0.129032258064516 1.99422243620607 0.137578151178501 0.461485870469626 GO:0140457 protein demethylase activity 4/1206 31/18639 0.129032258064516 1.99422243620607 0.137578151178501 0.461485870469626 GO:0120015 sterol transfer activity 4/1206 32/18639 0.125 1.93190298507463 0.149683966474634 0.491624693855528 GO:0005123 death receptor binding 3/1206 21/18639 0.142857142857143 2.20788912579957 0.151240380716341 0.491624693855528 GO:0035613 RNA stem-loop binding 3/1206 21/18639 0.142857142857143 2.20788912579957 0.151240380716341 0.491624693855528 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/1206 21/18639 0.142857142857143 2.20788912579957 0.151240380716341 0.491624693855528 GO:0170055 lipid transmembrane transporter activity 6/1206 56/18639 0.107142857142857 1.65591684434968 0.15228005273221 0.491624693855528 GO:0030547 signaling receptor inhibitor activity 5/1206 44/18639 0.113636363636364 1.75627544097693 0.153200605726666 0.491624693855528 GO:0019888 protein phosphatase regulator activity 10/1206 107/18639 0.0934579439252336 1.44441344678477 0.15420405750903 0.491624693855528 GO:0005114 type II transforming growth factor beta receptor binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0010854 adenylate cyclase regulator activity 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0019864 IgG binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0032050 clathrin heavy chain binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0032404 mismatch repair complex binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0034713 type I transforming growth factor beta receptor binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0043522 leucine zipper domain binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0048185 activin binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0048407 platelet-derived growth factor binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0070697 activin receptor binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0097493 structural molecule activity conferring elasticity 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:1900750 oligopeptide binding 2/1206 11/18639 0.181818181818182 2.81004070556309 0.156245985961247 0.491624693855528 GO:0004866 endopeptidase inhibitor activity 14/1206 161/18639 0.0869565217391304 1.34393251135626 0.159724165985644 0.499753202817828 GO:0005178 integrin binding 14/1206 161/18639 0.0869565217391304 1.34393251135626 0.159724165985644 0.499753202817828 GO:0004867 serine-type endopeptidase inhibitor activity 9/1206 95/18639 0.0947368421052632 1.46417910447761 0.160934440498494 0.502133435857034 GO:0071889 14-3-3 protein binding 4/1206 33/18639 0.121212121212121 1.8733604703754 0.162179180339892 0.504607644678717 GO:0008649 rRNA methyltransferase activity 3/1206 22/18639 0.136363636363636 2.10753052917232 0.167201971543431 0.514503036402238 GO:0030021 extracellular matrix structural constituent conferring compression resistance 3/1206 22/18639 0.136363636363636 2.10753052917232 0.167201971543431 0.514503036402238 GO:0140517 protein-RNA adaptor activity 3/1206 22/18639 0.136363636363636 2.10753052917232 0.167201971543431 0.514503036402238 GO:0140784 metal ion sensor activity 3/1206 22/18639 0.136363636363636 2.10753052917232 0.167201971543431 0.514503036402238 GO:0019902 phosphatase binding 16/1206 190/18639 0.0842105263157895 1.30149253731343 0.169384072344615 0.519785738486087 GO:0008376 acetylgalactosaminyltransferase activity 4/1206 34/18639 0.117647058823529 1.81826163301141 0.17503596698517 0.532614322965853 GO:0030332 cyclin binding 4/1206 34/18639 0.117647058823529 1.81826163301141 0.17503596698517 0.532614322965853 GO:0004526 ribonuclease P activity 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0004859 phospholipase inhibitor activity 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0005527 macrolide binding 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0015132 prostaglandin transmembrane transporter activity 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0043047 single-stranded telomeric DNA binding 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0070410 co-SMAD binding 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0097677 STAT family protein binding 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/1206 12/18639 0.166666666666667 2.57587064676617 0.179839570376974 0.532614322965853 GO:0004879 nuclear receptor activity 6/1206 59/18639 0.101694915254237 1.57171768277258 0.180716945751171 0.532614322965853 GO:0031593 polyubiquitin modification-dependent protein binding 6/1206 59/18639 0.101694915254237 1.57171768277258 0.180716945751171 0.532614322965853 GO:0031681 G-protein beta-subunit binding 3/1206 23/18639 0.130434782608696 2.01589876703439 0.183625168456426 0.536935374779655 GO:0070577 lysine-acetylated histone binding 3/1206 23/18639 0.130434782608696 2.01589876703439 0.183625168456426 0.536935374779655 GO:0140102 catalytic activity, acting on a rRNA 3/1206 23/18639 0.130434782608696 2.01589876703439 0.183625168456426 0.536935374779655 GO:0061749 forked DNA-dependent helicase activity 5/1206 47/18639 0.106382978723404 1.644172753255 0.185838188842675 0.540576189940803 GO:1990518 single-stranded 3'-5' DNA helicase activity 5/1206 47/18639 0.106382978723404 1.644172753255 0.185838188842675 0.540576189940803 GO:0098531 ligand-modulated transcription factor activity 6/1206 60/18639 0.1 1.5455223880597 0.190637510979314 0.553096363023101 GO:0016209 antioxidant activity 8/1206 86/18639 0.0930232558139535 1.4376952447067 0.191940082131354 0.555432828343841 GO:0009378 four-way junction helicase activity 5/1206 48/18639 0.104166666666667 1.60991915422886 0.197239322885106 0.561015617212706 GO:0036121 double-stranded DNA helicase activity 5/1206 48/18639 0.104166666666667 1.60991915422886 0.197239322885106 0.561015617212706 GO:0038187 pattern recognition receptor activity 5/1206 48/18639 0.104166666666667 1.60991915422886 0.197239322885106 0.561015617212706 GO:0043138 3'-5' DNA helicase activity 5/1206 48/18639 0.104166666666667 1.60991915422886 0.197239322885106 0.561015617212706 GO:0005506 iron ion binding 13/1206 154/18639 0.0844155844155844 1.30466175615429 0.197719470997146 0.561015617212706 GO:0050431 transforming growth factor beta binding 3/1206 24/18639 0.125 1.93190298507463 0.200450106401404 0.561015617212706 GO:0050699 WW domain binding 3/1206 24/18639 0.125 1.93190298507463 0.200450106401404 0.561015617212706 GO:0140033 acetylation-dependent protein binding 3/1206 24/18639 0.125 1.93190298507463 0.200450106401404 0.561015617212706 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 6/1206 61/18639 0.0983606557377049 1.52018595546856 0.200760934968269 0.561015617212706 GO:0003678 DNA helicase activity 7/1206 74/18639 0.0945945945945946 1.46198063735377 0.201376082868492 0.561015617212706 GO:0000993 RNA polymerase II complex binding 4/1206 36/18639 0.111111111111111 1.71724709784411 0.201720390357614 0.561015617212706 GO:0055106 ubiquitin-protein transferase regulator activity 4/1206 36/18639 0.111111111111111 1.71724709784411 0.201720390357614 0.561015617212706 GO:0005035 death receptor activity 2/1206 13/18639 0.153846153846154 2.37772675086108 0.2039143604193 0.561015617212706 GO:0005542 folic acid binding 2/1206 13/18639 0.153846153846154 2.37772675086108 0.2039143604193 0.561015617212706 GO:0019855 calcium channel inhibitor activity 2/1206 13/18639 0.153846153846154 2.37772675086108 0.2039143604193 0.561015617212706 GO:0030955 potassium ion binding 2/1206 13/18639 0.153846153846154 2.37772675086108 0.2039143604193 0.561015617212706 GO:0051011 microtubule minus-end binding 2/1206 13/18639 0.153846153846154 2.37772675086108 0.2039143604193 0.561015617212706 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/1206 13/18639 0.153846153846154 2.37772675086108 0.2039143604193 0.561015617212706 GO:0071714 icosanoid transmembrane transporter activity 2/1206 13/18639 0.153846153846154 2.37772675086108 0.2039143604193 0.561015617212706 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/1206 13/18639 0.153846153846154 2.37772675086108 0.2039143604193 0.561015617212706 GO:0030414 peptidase inhibitor activity 14/1206 169/18639 0.0828402366863905 1.28031440430981 0.205377896144587 0.563653832907871 GO:0035254 glutamate receptor binding 5/1206 49/18639 0.102040816326531 1.57706366128541 0.208873440331839 0.571842237379078 GO:0017124 SH3 domain binding 10/1206 115/18639 0.0869565217391304 1.34393251135626 0.210266131039628 0.574247599929742 GO:0019211 phosphatase activator activity 3/1206 25/18639 0.12 1.85462686567164 0.217618420488164 0.591434977336445 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/1206 25/18639 0.12 1.85462686567164 0.217618420488164 0.591434977336445 GO:0030983 mismatched DNA binding 2/1206 14/18639 0.142857142857143 2.20788912579957 0.228309484159978 0.617485941420571 GO:0043176 amine binding 2/1206 14/18639 0.142857142857143 2.20788912579957 0.228309484159978 0.617485941420571 GO:0005021 vascular endothelial growth factor receptor activity 5/1206 51/18639 0.0980392156862745 1.51521802750951 0.232771357760413 0.627007855645211 GO:0005160 transforming growth factor beta receptor binding 3/1206 26/18639 0.115384615384615 1.78329506314581 0.235073580265317 0.627007855645211 GO:0034237 protein kinase A regulatory subunit binding 3/1206 26/18639 0.115384615384615 1.78329506314581 0.235073580265317 0.627007855645211 GO:0050681 nuclear androgen receptor binding 3/1206 26/18639 0.115384615384615 1.78329506314581 0.235073580265317 0.627007855645211 GO:0052742 phosphatidylinositol kinase activity 3/1206 26/18639 0.115384615384615 1.78329506314581 0.235073580265317 0.627007855645211 GO:0072341 modified amino acid binding 8/1206 91/18639 0.0879120879120879 1.35870100049205 0.235198112368257 0.627007855645211 GO:0120013 lipid transfer activity 6/1206 65/18639 0.0923076923076923 1.42663605051665 0.24305428309217 0.646408652890367 GO:0004364 glutathione transferase activity 3/1206 27/18639 0.111111111111111 1.71724709784411 0.252761156656205 0.65538314317981 GO:0008320 protein transmembrane transporter activity 3/1206 27/18639 0.111111111111111 1.71724709784411 0.252761156656205 0.65538314317981 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1206 15/18639 0.133333333333333 2.06069651741294 0.252882842175916 0.65538314317981 GO:0004953 icosanoid receptor activity 2/1206 15/18639 0.133333333333333 2.06069651741294 0.252882842175916 0.65538314317981 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/1206 15/18639 0.133333333333333 2.06069651741294 0.252882842175916 0.65538314317981 GO:0017081 chloride channel regulator activity 2/1206 15/18639 0.133333333333333 2.06069651741294 0.252882842175916 0.65538314317981 GO:0031386 protein tag activity 2/1206 15/18639 0.133333333333333 2.06069651741294 0.252882842175916 0.65538314317981 GO:0033130 acetylcholine receptor binding 2/1206 15/18639 0.133333333333333 2.06069651741294 0.252882842175916 0.65538314317981 GO:0042809 nuclear vitamin D receptor binding 2/1206 15/18639 0.133333333333333 2.06069651741294 0.252882842175916 0.65538314317981 GO:0061578 K63-linked deubiquitinase activity 2/1206 15/18639 0.133333333333333 2.06069651741294 0.252882842175916 0.65538314317981 GO:0141047 molecular tag activity 2/1206 15/18639 0.133333333333333 2.06069651741294 0.252882842175916 0.65538314317981 GO:0004540 RNA nuclease activity 10/1206 121/18639 0.0826446280991736 1.27729122980141 0.257038334136727 0.662923816024358 GO:0004532 RNA exonuclease activity 4/1206 40/18639 0.1 1.5455223880597 0.25816639209543 0.662923816024358 GO:0061791 GTPase motor activity 4/1206 40/18639 0.1 1.5455223880597 0.25816639209543 0.662923816024358 GO:1990606 membrane scission GTPase motor activity 4/1206 40/18639 0.1 1.5455223880597 0.25816639209543 0.662923816024358 GO:0019842 vitamin binding 12/1206 150/18639 0.08 1.23641791044776 0.264771306739584 0.678324655110357 GO:0003925 G protein activity 5/1206 54/18639 0.0925925925925926 1.43103924820343 0.269929206749063 0.685470808427037 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 5/1206 54/18639 0.0925925925925926 1.43103924820343 0.269929206749063 0.685470808427037 GO:0019789 SUMO transferase activity 3/1206 28/18639 0.107142857142857 1.65591684434968 0.270629030005661 0.685470808427037 GO:0046625 sphingolipid binding 3/1206 28/18639 0.107142857142857 1.65591684434968 0.270629030005661 0.685470808427037 GO:0046875 ephrin receptor binding 3/1206 28/18639 0.107142857142857 1.65591684434968 0.270629030005661 0.685470808427037 GO:0015175 neutral L-amino acid transmembrane transporter activity 4/1206 41/18639 0.0975609756097561 1.50782672005825 0.272752595822418 0.68709206165871 GO:0140318 protein transporter activity 4/1206 41/18639 0.0975609756097561 1.50782672005825 0.272752595822418 0.68709206165871 GO:0004620 phospholipase activity 9/1206 109/18639 0.0825688073394495 1.27611940298507 0.273114481089049 0.68709206165871 GO:0030145 manganese ion binding 6/1206 68/18639 0.0882352941176471 1.36369622475856 0.276331427406303 0.690374052434268 GO:0000062 fatty-acyl-CoA binding 2/1206 16/18639 0.125 1.93190298507463 0.27750935500715 0.690374052434268 GO:0003688 DNA replication origin binding 2/1206 16/18639 0.125 1.93190298507463 0.27750935500715 0.690374052434268 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/1206 16/18639 0.125 1.93190298507463 0.27750935500715 0.690374052434268 GO:0030275 LRR domain binding 2/1206 16/18639 0.125 1.93190298507463 0.27750935500715 0.690374052434268 GO:0004518 nuclease activity 16/1206 209/18639 0.076555023923445 1.1831750339213 0.278741679377429 0.691898790810196 GO:0022804 active transmembrane transporter activity 33/1206 457/18639 0.0722100656455142 1.11602273098403 0.280186691976578 0.693943536447533 GO:0008374 O-acyltransferase activity 5/1206 55/18639 0.0909090909090909 1.40502035278155 0.282594470860245 0.696816829913673 GO:0098632 cell-cell adhesion mediator activity 5/1206 55/18639 0.0909090909090909 1.40502035278155 0.282594470860245 0.696816829913673 GO:0004402 histone acetyltransferase activity 4/1206 42/18639 0.0952380952380952 1.47192608386638 0.287473201888467 0.705730915405314 GO:0051879 Hsp90 protein binding 4/1206 42/18639 0.0952380952380952 1.47192608386638 0.287473201888467 0.705730915405314 GO:0019212 phosphatase inhibitor activity 5/1206 56/18639 0.0892857142857143 1.37993070362473 0.295370394206131 0.712385651208956 GO:0004713 protein tyrosine kinase activity 11/1206 140/18639 0.0785714285714286 1.21433901918977 0.296629385864281 0.712385651208956 GO:0043022 ribosome binding 9/1206 112/18639 0.0803571428571429 1.24193763326226 0.29976080249907 0.712385651208956 GO:0004527 exonuclease activity 7/1206 84/18639 0.0833333333333333 1.28793532338308 0.300499793866533 0.712385651208956 GO:0004550 nucleoside diphosphate kinase activity 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0004659 prenyltransferase activity 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0019198 transmembrane receptor protein phosphatase activity 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0030548 acetylcholine receptor regulator activity 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0032183 SUMO binding 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0032977 membrane insertase activity 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0038191 neuropilin binding 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0048038 quinone binding 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0051787 misfolded protein binding 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:1901567 fatty acid derivative binding 2/1206 17/18639 0.117647058823529 1.81826163301141 0.302079358522932 0.712385651208956 GO:0008375 acetylglucosaminyltransferase activity 4/1206 43/18639 0.0930232558139535 1.4376952447067 0.302301520745788 0.712385651208956 GO:0031210 phosphatidylcholine binding 3/1206 30/18639 0.1 1.5455223880597 0.306709631854572 0.718588106809742 GO:0051721 protein phosphatase 2A binding 3/1206 30/18639 0.1 1.5455223880597 0.306709631854572 0.718588106809742 GO:0004519 endonuclease activity 10/1206 127/18639 0.078740157480315 1.21694676225173 0.30686349771553 0.718588106809742 GO:0001223 transcription coactivator binding 4/1206 44/18639 0.0909090909090909 1.40502035278155 0.3172116122477 0.73971893712042 GO:0016248 channel inhibitor activity 4/1206 44/18639 0.0909090909090909 1.40502035278155 0.3172116122477 0.73971893712042 GO:0005085 guanyl-nucleotide exchange factor activity 17/1206 230/18639 0.0739130434782609 1.14234263465282 0.320183483053569 0.739751116146907 GO:0008408 3'-5' exonuclease activity 5/1206 58/18639 0.0862068965517241 1.33234688625836 0.321186067594554 0.739751116146907 GO:0017116 single-stranded DNA helicase activity 5/1206 58/18639 0.0862068965517241 1.33234688625836 0.321186067594554 0.739751116146907 GO:0000400 four-way junction DNA binding 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:0008525 phosphatidylcholine transporter activity 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:0070064 proline-rich region binding 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:0070628 proteasome binding 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:0098641 cadherin binding involved in cell-cell adhesion 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:0099602 neurotransmitter receptor regulator activity 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:1901611 phosphatidylglycerol binding 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:1990381 ubiquitin-specific protease binding 2/1206 18/18639 0.111111111111111 1.71724709784411 0.326497135416674 0.739751116146907 GO:0008081 phosphoric diester hydrolase activity 7/1206 87/18639 0.0804597701149425 1.24352376050781 0.332134446414665 0.748071024710391 GO:0046915 transition metal ion transmembrane transporter activity 4/1206 45/18639 0.0888888888888889 1.37379767827529 0.332178360122072 0.748071024710391 GO:0141110 transporter inhibitor activity 4/1206 45/18639 0.0888888888888889 1.37379767827529 0.332178360122072 0.748071024710391 GO:0004521 RNA endonuclease activity 6/1206 73/18639 0.0821917808219178 1.2702923737477 0.333790924085842 0.748082137262065 GO:0015459 potassium channel regulator activity 5/1206 59/18639 0.0847457627118644 1.30976473564381 0.334192467765238 0.748082137262065 GO:0045309 protein phosphorylated amino acid binding 5/1206 59/18639 0.0847457627118644 1.30976473564381 0.334192467765238 0.748082137262065 GO:0004197 cysteine-type endopeptidase activity 7/1206 88/18639 0.0795454545454545 1.22939280868385 0.342790023564284 0.760068647855945 GO:0008378 galactosyltransferase activity 3/1206 32/18639 0.09375 1.44892723880597 0.342949506284151 0.760068647855945 GO:0022884 macromolecule transmembrane transporter activity 3/1206 32/18639 0.09375 1.44892723880597 0.342949506284151 0.760068647855945 GO:0031369 translation initiation factor binding 3/1206 32/18639 0.09375 1.44892723880597 0.342949506284151 0.760068647855945 GO:0051059 NF-kappaB binding 3/1206 32/18639 0.09375 1.44892723880597 0.342949506284151 0.760068647855945 GO:0031491 nucleosome binding 6/1206 74/18639 0.0810810810810811 1.25312626058895 0.345474586546197 0.762079925821547 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/1206 60/18639 0.0833333333333333 1.28793532338308 0.34724291838214 0.762079925821547 GO:0003756 protein disulfide isomerase activity 2/1206 19/18639 0.105263157894737 1.62686567164179 0.350679571953693 0.762079925821547 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/1206 19/18639 0.105263157894737 1.62686567164179 0.350679571953693 0.762079925821547 GO:0031420 alkali metal ion binding 2/1206 19/18639 0.105263157894737 1.62686567164179 0.350679571953693 0.762079925821547 GO:0050145 nucleoside monophosphate kinase activity 2/1206 19/18639 0.105263157894737 1.62686567164179 0.350679571953693 0.762079925821547 GO:0070003 threonine-type peptidase activity 2/1206 19/18639 0.105263157894737 1.62686567164179 0.350679571953693 0.762079925821547 GO:0120227 acyl-CoA binding 2/1206 19/18639 0.105263157894737 1.62686567164179 0.350679571953693 0.762079925821547 GO:0140036 ubiquitin-modified protein reader activity 2/1206 19/18639 0.105263157894737 1.62686567164179 0.350679571953693 0.762079925821547 GO:1990380 K48-linked deubiquitinase activity 2/1206 19/18639 0.105263157894737 1.62686567164179 0.350679571953693 0.762079925821547 GO:0001784 phosphotyrosine residue binding 4/1206 47/18639 0.0851063829787234 1.315338202604 0.362185846177837 0.782517582554437 GO:0061733 protein-lysine-acetyltransferase activity 4/1206 47/18639 0.0851063829787234 1.315338202604 0.362185846177837 0.782517582554437 GO:0140359 ABC-type transporter activity 4/1206 47/18639 0.0851063829787234 1.315338202604 0.362185846177837 0.782517582554437 GO:0005319 lipid transporter activity 13/1206 178/18639 0.0730337078651685 1.1287523058863 0.366781345809108 0.7909165314069 GO:0051536 iron-sulfur cluster binding 6/1206 76/18639 0.0789473684210526 1.22014925373134 0.368940768618555 0.794040151342825 GO:0001614 purinergic nucleotide receptor activity 2/1206 20/18639 0.1 1.5455223880597 0.374554929931513 0.796752130436344 GO:0010851 cyclase regulator activity 2/1206 20/18639 0.1 1.5455223880597 0.374554929931513 0.796752130436344 GO:0016502 nucleotide receptor activity 2/1206 20/18639 0.1 1.5455223880597 0.374554929931513 0.796752130436344 GO:0016505 peptidase activator activity involved in apoptotic process 2/1206 20/18639 0.1 1.5455223880597 0.374554929931513 0.796752130436344 GO:0030742 GTP-dependent protein binding 2/1206 20/18639 0.1 1.5455223880597 0.374554929931513 0.796752130436344 GO:0052745 inositol phosphate phosphatase activity 2/1206 20/18639 0.1 1.5455223880597 0.374554929931513 0.796752130436344 GO:0004674 protein serine/threonine kinase activity 30/1206 433/18639 0.069284064665127 1.0708007307573 0.375193930715772 0.796752130436344 GO:0015020 glucuronosyltransferase activity 3/1206 34/18639 0.0882352941176471 1.36369622475856 0.379025626481164 0.800324432475351 GO:0015035 protein-disulfide reductase activity 3/1206 34/18639 0.0882352941176471 1.36369622475856 0.379025626481164 0.800324432475351 GO:0019825 oxygen binding 3/1206 34/18639 0.0882352941176471 1.36369622475856 0.379025626481164 0.800324432475351 GO:0008514 organic anion transmembrane transporter activity 19/1206 269/18639 0.0706319702602231 1.09163291349942 0.379888767915981 0.800633497664434 GO:0051540 metal cluster binding 6/1206 77/18639 0.0779220779220779 1.20430315952704 0.380700969759649 0.800834243355042 GO:0016763 pentosyltransferase activity 4/1206 49/18639 0.0816326530612245 1.26165092902833 0.392141655265853 0.822482472417272 GO:0019199 transmembrane receptor protein kinase activity 6/1206 78/18639 0.0769230769230769 1.18886337543054 0.392464778691501 0.822482472417272 GO:0000175 3'-5'-RNA exonuclease activity 3/1206 35/18639 0.0857142857142857 1.32473347547974 0.396913096522229 0.827998037918572 GO:0005154 epidermal growth factor receptor binding 3/1206 35/18639 0.0857142857142857 1.32473347547974 0.396913096522229 0.827998037918572 GO:0061891 calcium ion sensor activity 2/1206 21/18639 0.0952380952380952 1.47192608386638 0.398061724585741 0.827998037918572 GO:0072542 protein phosphatase activator activity 2/1206 21/18639 0.0952380952380952 1.47192608386638 0.398061724585741 0.827998037918572 GO:0016247 channel regulator activity 12/1206 168/18639 0.0714285714285714 1.10394456289979 0.40454972510015 0.839929447838044 GO:0070851 growth factor receptor binding 10/1206 139/18639 0.0719424460431655 1.11188661011489 0.411650597067477 0.853086673329076 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/1206 36/18639 0.0833333333333333 1.28793532338308 0.414657887991739 0.856142071879431 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/1206 36/18639 0.0833333333333333 1.28793532338308 0.414657887991739 0.856142071879431 GO:0004222 metalloendopeptidase activity 8/1206 110/18639 0.0727272727272727 1.12401628222524 0.419326712705511 0.861498241459047 GO:0141108 transporter regulator activity 12/1206 170/18639 0.0705882352941176 1.09095697980685 0.420591418153277 0.861498241459047 GO:0015377 chloride:monoatomic cation symporter activity 2/1206 22/18639 0.0909090909090909 1.40502035278155 0.421147699889972 0.861498241459047 GO:0140035 ubiquitin-like protein reader activity 2/1206 22/18639 0.0909090909090909 1.40502035278155 0.421147699889972 0.861498241459047 GO:0005048 signal sequence binding 4/1206 51/18639 0.0784313725490196 1.21217442200761 0.421879622272246 0.861498241459047 GO:0016597 amino acid binding 4/1206 51/18639 0.0784313725490196 1.21217442200761 0.421879622272246 0.861498241459047 GO:0016407 acetyltransferase activity 7/1206 96/18639 0.0729166666666667 1.1269434079602 0.428782079712225 0.873995589486415 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/1206 23/18639 0.0869565217391304 1.34393251135626 0.443768893359834 0.88600794330064 GO:0005158 insulin receptor binding 2/1206 23/18639 0.0869565217391304 1.34393251135626 0.443768893359834 0.88600794330064 GO:0005283 amino acid:sodium symporter activity 2/1206 23/18639 0.0869565217391304 1.34393251135626 0.443768893359834 0.88600794330064 GO:0043274 phospholipase binding 2/1206 23/18639 0.0869565217391304 1.34393251135626 0.443768893359834 0.88600794330064 GO:0140103 catalytic activity, acting on a glycoprotein 2/1206 23/18639 0.0869565217391304 1.34393251135626 0.443768893359834 0.88600794330064 GO:0005109 frizzled binding 3/1206 38/18639 0.0789473684210526 1.22014925373134 0.449607859082737 0.88600794330064 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/1206 38/18639 0.0789473684210526 1.22014925373134 0.449607859082737 0.88600794330064 GO:0030165 PDZ domain binding 6/1206 83/18639 0.072289156626506 1.11724509980219 0.450980606991658 0.88600794330064 GO:0004864 protein phosphatase inhibitor activity 4/1206 53/18639 0.0754716981132075 1.16643199098845 0.451250410226535 0.88600794330064 GO:0034212 protein N-acetyltransferase activity 4/1206 53/18639 0.0754716981132075 1.16643199098845 0.451250410226535 0.88600794330064 GO:0001664 G protein-coupled receptor binding 20/1206 297/18639 0.0673400673400673 1.04075581687522 0.459891515488392 0.88600794330064 GO:0008080 N-acetyltransferase activity 5/1206 69/18639 0.072463768115942 1.11994375946355 0.464235901677358 0.88600794330064 GO:0008194 UDP-glycosyltransferase activity 10/1206 145/18639 0.0689655172413793 1.06587750900669 0.464599730032638 0.88600794330064 GO:0004175 endopeptidase activity 27/1206 405/18639 0.0666666666666667 1.03034825870647 0.464694192363412 0.88600794330064 GO:0051287 NAD binding 4/1206 54/18639 0.0740740740740741 1.14483139856274 0.465756106504733 0.88600794330064 GO:0005540 hyaluronic acid binding 2/1206 24/18639 0.0833333333333333 1.28793532338308 0.465888783083328 0.88600794330064 GO:0030215 semaphorin receptor binding 2/1206 24/18639 0.0833333333333333 1.28793532338308 0.465888783083328 0.88600794330064 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1206 24/18639 0.0833333333333333 1.28793532338308 0.465888783083328 0.88600794330064 GO:0016298 lipase activity 9/1206 130/18639 0.0692307692307692 1.06997703788749 0.466737525795439 0.88600794330064 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/1206 39/18639 0.0769230769230769 1.18886337543054 0.466763352099074 0.88600794330064 GO:0035401 histone H3Y41 kinase activity 8/1206 115/18639 0.0695652173913043 1.07514600908501 0.469008842867727 0.88600794330064 GO:0140801 histone H2AXY142 kinase activity 8/1206 115/18639 0.0695652173913043 1.07514600908501 0.469008842867727 0.88600794330064 GO:0005516 calmodulin binding 14/1206 207/18639 0.0676328502415459 1.04528084216598 0.47176562359229 0.88600794330064 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/1206 70/18639 0.0714285714285714 1.10394456289979 0.476940508234707 0.88600794330064 GO:0015294 solute:monoatomic cation symporter activity 8/1206 116/18639 0.0689655172413793 1.06587750900669 0.478847780708439 0.88600794330064 GO:0004177 aminopeptidase activity 3/1206 40/18639 0.075 1.15914179104478 0.483676619126396 0.88600794330064 GO:0015036 disulfide oxidoreductase activity 3/1206 40/18639 0.075 1.15914179104478 0.483676619126396 0.88600794330064 GO:0050997 quaternary ammonium group binding 3/1206 40/18639 0.075 1.15914179104478 0.483676619126396 0.88600794330064 GO:0050660 flavin adenine dinucleotide binding 6/1206 86/18639 0.0697674418604651 1.07827143353002 0.485508619304109 0.88600794330064 GO:0008139 nuclear localization sequence binding 2/1206 25/18639 0.08 1.23641791044776 0.487477510265516 0.88600794330064 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/1206 25/18639 0.08 1.23641791044776 0.487477510265516 0.88600794330064 GO:0042974 nuclear retinoic acid receptor binding 2/1206 25/18639 0.08 1.23641791044776 0.487477510265516 0.88600794330064 GO:0004090 carbonyl reductase (NADPH) activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0004382 GDP phosphatase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0004935 adrenergic receptor activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0004955 prostaglandin receptor activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0005131 growth hormone receptor binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0005345 purine nucleobase transmembrane transporter activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0008140 cAMP response element binding protein binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0016868 intramolecular phosphotransferase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0032356 oxidized DNA binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0033204 ribonuclease P RNA binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0042166 acetylcholine binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0042975 peroxisome proliferator activated receptor binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0043121 neurotrophin binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0043208 glycosphingolipid binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0045322 unmethylated CpG binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0050308 sugar-phosphatase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0050815 phosphoserine residue binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0098505 G-rich strand telomeric DNA binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0099122 RNA polymerase II C-terminal domain binding 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0140940 histone H2A methyltransferase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:0140999 histone H3K4 trimethyltransferase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:1990259 histone H2AQ104 methyltransferase activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:1990757 ubiquitin ligase activator activity 1/1206 10/18639 0.1 1.5455223880597 0.487819950877255 0.88600794330064 GO:1990782 protein tyrosine kinase binding 8/1206 117/18639 0.0683760683760684 1.05676744482715 0.488641364078123 0.886059096875428 GO:0003779 actin binding 29/1206 443/18639 0.0654627539503386 1.01174151814292 0.501919395412957 0.892290430735569 GO:0005112 Notch binding 2/1206 26/18639 0.0769230769230769 1.18886337543054 0.508511171098865 0.892290430735569 GO:0019865 immunoglobulin binding 2/1206 26/18639 0.0769230769230769 1.18886337543054 0.508511171098865 0.892290430735569 GO:0030247 polysaccharide binding 2/1206 26/18639 0.0769230769230769 1.18886337543054 0.508511171098865 0.892290430735569 GO:0030507 spectrin binding 2/1206 26/18639 0.0769230769230769 1.18886337543054 0.508511171098865 0.892290430735569 GO:0043548 phosphatidylinositol 3-kinase binding 2/1206 26/18639 0.0769230769230769 1.18886337543054 0.508511171098865 0.892290430735569 GO:0070006 metalloaminopeptidase activity 2/1206 26/18639 0.0769230769230769 1.18886337543054 0.508511171098865 0.892290430735569 GO:0016758 hexosyltransferase activity 13/1206 197/18639 0.065989847715736 1.0198878702932 0.511990351098198 0.892290430735569 GO:0019894 kinesin binding 3/1206 42/18639 0.0714285714285714 1.10394456289979 0.516702001381069 0.892290430735569 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0001851 complement component C3b binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0004954 prostanoid receptor activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0005536 D-glucose binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0008172 S-methyltransferase activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0008199 ferric iron binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0008526 phosphatidylinositol transfer activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0015205 nucleobase transmembrane transporter activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0015217 ADP transmembrane transporter activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0019203 carbohydrate phosphatase activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0019215 intermediate filament binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0031731 CCR6 chemokine receptor binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0032794 GTPase activating protein binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0047676 arachidonate-CoA ligase activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0050786 RAGE receptor binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0050998 nitric-oxide synthase binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0070990 snRNP binding 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0140537 transcription regulator activator activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0180030 inositol phosphate kinase activity 1/1206 11/18639 0.0909090909090909 1.40502035278155 0.520977347368856 0.892290430735569 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1206 27/18639 0.0740740740740741 1.14483139856274 0.528971172254278 0.892290430735569 GO:0008266 poly(U) RNA binding 2/1206 27/18639 0.0740740740740741 1.14483139856274 0.528971172254278 0.892290430735569 GO:0015252 proton channel activity 2/1206 27/18639 0.0740740740740741 1.14483139856274 0.528971172254278 0.892290430735569 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1206 27/18639 0.0740740740740741 1.14483139856274 0.528971172254278 0.892290430735569 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/1206 27/18639 0.0740740740740741 1.14483139856274 0.528971172254278 0.892290430735569 GO:0008200 ion channel inhibitor activity 3/1206 43/18639 0.0697674418604651 1.07827143353002 0.532782037428715 0.892290430735569 GO:0016829 lyase activity 13/1206 200/18639 0.065 1.00458955223881 0.534380195641577 0.892290430735569 GO:0001786 phosphatidylserine binding 4/1206 59/18639 0.0677966101694915 1.04781178851505 0.535920731044808 0.892290430735569 GO:0070888 E-box binding 4/1206 59/18639 0.0677966101694915 1.04781178851505 0.535920731044808 0.892290430735569 GO:0019205 nucleobase-containing compound kinase activity 3/1206 44/18639 0.0681818181818182 1.05376526458616 0.548555483173668 0.892290430735569 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/1206 44/18639 0.0681818181818182 1.05376526458616 0.548555483173668 0.892290430735569 GO:0043014 alpha-tubulin binding 3/1206 44/18639 0.0681818181818182 1.05376526458616 0.548555483173668 0.892290430735569 GO:0045499 chemorepellent activity 2/1206 28/18639 0.0714285714285714 1.10394456289979 0.548843644734941 0.892290430735569 GO:0051959 dynein light intermediate chain binding 2/1206 28/18639 0.0714285714285714 1.10394456289979 0.548843644734941 0.892290430735569 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/1206 28/18639 0.0714285714285714 1.10394456289979 0.548843644734941 0.892290430735569 GO:0000340 RNA 7-methylguanosine cap binding 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0003995 acyl-CoA dehydrogenase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0004126 cytidine deaminase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0004875 complement receptor activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0005078 MAP-kinase scaffold activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0005095 GTPase inhibitor activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0005165 neurotrophin receptor binding 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0008504 monoamine transmembrane transporter activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0010853 cyclase activator activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0015166 polyol transmembrane transporter activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0016208 AMP binding 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0016840 carbon-nitrogen lyase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0017166 vinculin binding 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0035497 cAMP response element binding 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0036009 protein-glutamine N-methyltransferase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0042301 phosphate ion binding 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:1990817 poly(A) RNA polymerase activity 1/1206 12/18639 0.0833333333333333 1.28793532338308 0.551989872549935 0.892290430735569 GO:0008234 cysteine-type peptidase activity 12/1206 187/18639 0.0641711229946524 0.99177907255168 0.55453435362384 0.895108197973741 GO:0046943 carboxylic acid transmembrane transporter activity 12/1206 188/18639 0.0638297872340425 0.986503651953001 0.56210771165193 0.902579194874994 GO:0019905 syntaxin binding 4/1206 61/18639 0.0655737704918033 1.01345730364571 0.562666212453909 0.902579194874994 GO:0051219 phosphoprotein binding 6/1206 93/18639 0.0645161290322581 0.997111218103033 0.562973983544938 0.902579194874994 GO:0016757 glycosyltransferase activity 17/1206 267/18639 0.0636704119850187 0.984040471798312 0.563491998598813 0.902579194874994 GO:0051539 4 iron, 4 sulfur cluster binding 3/1206 45/18639 0.0666666666666667 1.03034825870647 0.564010991963067 0.902579194874994 GO:0140303 intramembrane lipid transporter activity 3/1206 45/18639 0.0666666666666667 1.03034825870647 0.564010991963067 0.902579194874994 GO:0005416 amino acid:monoatomic cation symporter activity 2/1206 29/18639 0.0689655172413793 1.06587750900669 0.568118911248344 0.903861722227165 GO:0035250 UDP-galactosyltransferase activity 2/1206 29/18639 0.0689655172413793 1.06587750900669 0.568118911248344 0.903861722227165 GO:0106222 lncRNA binding 2/1206 29/18639 0.0689655172413793 1.06587750900669 0.568118911248344 0.903861722227165 GO:0005342 organic acid transmembrane transporter activity 12/1206 189/18639 0.0634920634920635 0.981284055910921 0.569631186295338 0.903861722227165 GO:0016410 N-acyltransferase activity 6/1206 94/18639 0.0638297872340425 0.986503651953001 0.573589769659278 0.903861722227165 GO:0020037 heme binding 9/1206 142/18639 0.0633802816901408 0.979556443136431 0.574541721130346 0.903861722227165 GO:0015179 L-amino acid transmembrane transporter activity 4/1206 62/18639 0.0645161290322581 0.997111218103033 0.575718130827971 0.903861722227165 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/1206 46/18639 0.0652173913043478 1.0079493835172 0.579138907571053 0.903861722227165 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0004535 poly(A)-specific ribonuclease activity 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0008253 5'-nucleotidase activity 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0019104 DNA N-glycosylase activity 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0031994 insulin-like growth factor I binding 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0035673 oligopeptide transmembrane transporter activity 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0046974 histone H3K9 methyltransferase activity 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0089720 caspase binding 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0140333 glycerophospholipid flippase activity 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0140666 annealing activity 1/1206 13/18639 0.0769230769230769 1.18886337543054 0.580996165227489 0.903861722227165 GO:0015370 solute:sodium symporter activity 5/1206 79/18639 0.0632911392405063 0.978178726620064 0.585645859999332 0.905311533068709 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/1206 30/18639 0.0666666666666667 1.03034825870647 0.586791002633613 0.905311533068709 GO:0015215 nucleotide transmembrane transporter activity 2/1206 30/18639 0.0666666666666667 1.03034825870647 0.586791002633613 0.905311533068709 GO:0031624 ubiquitin conjugating enzyme binding 2/1206 30/18639 0.0666666666666667 1.03034825870647 0.586791002633613 0.905311533068709 GO:0033612 receptor serine/threonine kinase binding 2/1206 30/18639 0.0666666666666667 1.03034825870647 0.586791002633613 0.905311533068709 GO:0070566 adenylyltransferase activity 2/1206 30/18639 0.0666666666666667 1.03034825870647 0.586791002633613 0.905311533068709 GO:0005504 fatty acid binding 3/1206 47/18639 0.0638297872340425 0.986503651953001 0.593931161756954 0.905971054952626 GO:0043495 protein-membrane adaptor activity 3/1206 47/18639 0.0638297872340425 0.986503651953001 0.593931161756954 0.905971054952626 GO:0048306 calcium-dependent protein binding 5/1206 80/18639 0.0625 0.965951492537313 0.596958152554578 0.905971054952626 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/1206 31/18639 0.0645161290322581 0.997111218103033 0.604857219234068 0.905971054952626 GO:0072349 modified amino acid transmembrane transporter activity 2/1206 31/18639 0.0645161290322581 0.997111218103033 0.604857219234068 0.905971054952626 GO:0015631 tubulin binding 24/1206 385/18639 0.0623376623376623 0.963442527621632 0.605767628848034 0.905971054952626 GO:0008083 growth factor activity 10/1206 162/18639 0.0617283950617284 0.954026165468951 0.607371711704767 0.905971054952626 GO:0015101 organic cation transmembrane transporter activity 5/1206 81/18639 0.0617283950617284 0.954026165468951 0.608095252964024 0.905971054952626 GO:0030971 receptor tyrosine kinase binding 5/1206 81/18639 0.0617283950617284 0.954026165468951 0.608095252964024 0.905971054952626 GO:0005313 L-glutamate transmembrane transporter activity 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0005347 ATP transmembrane transporter activity 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0005545 1-phosphatidylinositol binding 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0008494 translation activator activity 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0008559 ABC-type xenobiotic transporter activity 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0019763 immunoglobulin receptor activity 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0019992 diacylglycerol binding 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0042043 neurexin family protein binding 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0044548 S100 protein binding 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0046030 inositol trisphosphate phosphatase activity 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0061665 SUMO ligase activity 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:1901612 cardiolipin binding 1/1206 14/18639 0.0714285714285714 1.10394456289979 0.608125909924989 0.905971054952626 GO:0015293 symporter activity 9/1206 146/18639 0.0616438356164384 0.952719280310775 0.608317219557942 0.905971054952626 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/1206 48/18639 0.0625 0.965951492537313 0.608381173563484 0.905971054952626 GO:0042626 ATPase-coupled transmembrane transporter activity 6/1206 98/18639 0.0612244897959184 0.946238196771246 0.614717539168766 0.905971054952626 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1206 32/18639 0.0625 0.965951492537313 0.622317733430729 0.905971054952626 GO:0042910 xenobiotic transmembrane transporter activity 2/1206 32/18639 0.0625 0.965951492537313 0.622317733430729 0.905971054952626 GO:0043425 bHLH transcription factor binding 2/1206 32/18639 0.0625 0.965951492537313 0.622317733430729 0.905971054952626 GO:0005004 GPI-linked ephrin receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0005008 hepatocyte growth factor receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0005009 insulin receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0005011 macrophage colony-stimulating factor receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0005020 stem cell factor receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0008288 boss receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0036332 placental growth factor receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0038062 protein tyrosine kinase collagen receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0060175 brain-derived neurotrophic factor receptor activity 3/1206 49/18639 0.0612244897959184 0.946238196771246 0.622483750843765 0.905971054952626 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 14/1206 229/18639 0.0611353711790393 0.944860848595451 0.626159514942343 0.905971054952626 GO:0004089 carbonate dehydratase activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0008252 nucleotidase activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0015929 hexosaminidase activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0031005 filamin binding 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0034483 heparan sulfate sulfotransferase activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0047372 monoacylglycerol lipase activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0050780 dopamine receptor binding 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0051371 muscle alpha-actinin binding 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0141050 histone H3K deacetylase activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0141051 histone H4K deacetylase activity 1/1206 15/18639 0.0666666666666667 1.03034825870647 0.633500414764209 0.905971054952626 GO:0005006 epidermal growth factor receptor activity 3/1206 50/18639 0.06 0.927313432835821 0.636234994417225 0.905971054952626 GO:0005007 fibroblast growth factor receptor activity 3/1206 50/18639 0.06 0.927313432835821 0.636234994417225 0.905971054952626 GO:0005017 platelet-derived growth factor receptor activity 3/1206 50/18639 0.06 0.927313432835821 0.636234994417225 0.905971054952626 GO:0005019 platelet-derived growth factor beta-receptor activity 3/1206 50/18639 0.06 0.927313432835821 0.636234994417225 0.905971054952626 GO:0015605 organophosphate ester transmembrane transporter activity 3/1206 50/18639 0.06 0.927313432835821 0.636234994417225 0.905971054952626 GO:0008173 RNA methyltransferase activity 4/1206 67/18639 0.0597014925373134 0.922699933169971 0.637505146994417 0.905971054952626 GO:0016500 protein-hormone receptor activity 4/1206 67/18639 0.0597014925373134 0.922699933169971 0.637505146994417 0.905971054952626 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/1206 67/18639 0.0597014925373134 0.922699933169971 0.637505146994417 0.905971054952626 GO:0042054 histone methyltransferase activity 4/1206 67/18639 0.0597014925373134 0.922699933169971 0.637505146994417 0.905971054952626 GO:0005548 phospholipid transporter activity 4/1206 68/18639 0.0588235294117647 0.909130816505707 0.649134203361133 0.909701896994874 GO:0005010 insulin-like growth factor receptor activity 3/1206 51/18639 0.0588235294117647 0.909130816505707 0.649632205176286 0.909701896994874 GO:0005030 neurotrophin receptor activity 3/1206 51/18639 0.0588235294117647 0.909130816505707 0.649632205176286 0.909701896994874 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/1206 34/18639 0.0588235294117647 0.909130816505707 0.655434580064217 0.909701896994874 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/1206 34/18639 0.0588235294117647 0.909130816505707 0.655434580064217 0.909701896994874 GO:0051427 hormone receptor binding 2/1206 34/18639 0.0588235294117647 0.909130816505707 0.655434580064217 0.909701896994874 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/1206 34/18639 0.0588235294117647 0.909130816505707 0.655434580064217 0.909701896994874 GO:0046906 tetrapyrrole binding 9/1206 152/18639 0.0592105263157895 0.915111940298508 0.656319467432176 0.909701896994874 GO:0005024 transforming growth factor beta receptor activity 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0005149 interleukin-1 receptor binding 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0005521 lamin binding 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0015378 sodium:chloride symporter activity 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0015562 efflux transmembrane transporter activity 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0022858 alanine transmembrane transporter activity 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0070411 I-SMAD binding 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0140327 flippase activity 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0140328 floppase activity 1/1206 16/18639 0.0625 0.965951492537313 0.657233152081346 0.909701896994874 GO:0016779 nucleotidyltransferase activity 8/1206 136/18639 0.0588235294117647 0.909130816505707 0.660307347877399 0.912825875716652 GO:0030159 signaling receptor complex adaptor activity 3/1206 52/18639 0.0576923076923077 0.891647531572905 0.662673794397069 0.914964929964804 GO:0003774 cytoskeletal motor activity 9/1206 153/18639 0.0588235294117647 0.909130816505707 0.663982691050425 0.915640328275709 GO:0005343 organic acid:sodium symporter activity 2/1206 35/18639 0.0571428571428571 0.883155650319829 0.671102548763731 0.922195699869012 GO:0016229 steroid dehydrogenase activity 2/1206 35/18639 0.0571428571428571 0.883155650319829 0.671102548763731 0.922195699869012 GO:0005003 ephrin receptor activity 3/1206 53/18639 0.0566037735849057 0.874823993241341 0.675359197447302 0.922195699869012 GO:0005005 transmembrane-ephrin receptor activity 3/1206 53/18639 0.0566037735849057 0.874823993241341 0.675359197447302 0.922195699869012 GO:0038064 collagen receptor activity 3/1206 53/18639 0.0566037735849057 0.874823993241341 0.675359197447302 0.922195699869012 GO:0051018 protein kinase A binding 3/1206 53/18639 0.0566037735849057 0.874823993241341 0.675359197447302 0.922195699869012 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/1206 17/18639 0.0588235294117647 0.909130816505707 0.679430264178747 0.922195699869012 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/1206 17/18639 0.0588235294117647 0.909130816505707 0.679430264178747 0.922195699869012 GO:0008484 sulfuric ester hydrolase activity 1/1206 17/18639 0.0588235294117647 0.909130816505707 0.679430264178747 0.922195699869012 GO:0017110 nucleoside diphosphate phosphatase activity 1/1206 17/18639 0.0588235294117647 0.909130816505707 0.679430264178747 0.922195699869012 GO:0045125 bioactive lipid receptor activity 1/1206 17/18639 0.0588235294117647 0.909130816505707 0.679430264178747 0.922195699869012 GO:0046965 nuclear retinoid X receptor binding 1/1206 17/18639 0.0588235294117647 0.909130816505707 0.679430264178747 0.922195699869012 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/1206 122/18639 0.0573770491803279 0.886775140689993 0.682218515554714 0.922195699869012 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 7/1206 122/18639 0.0573770491803279 0.886775140689993 0.682218515554714 0.922195699869012 GO:0004033 aldo-keto reductase (NADPH) activity 2/1206 36/18639 0.0555555555555556 0.858623548922056 0.686187528809142 0.922195699869012 GO:0004190 aspartic-type endopeptidase activity 2/1206 36/18639 0.0555555555555556 0.858623548922056 0.686187528809142 0.922195699869012 GO:0045505 dynein intermediate chain binding 2/1206 36/18639 0.0555555555555556 0.858623548922056 0.686187528809142 0.922195699869012 GO:0046982 protein heterodimerization activity 22/1206 369/18639 0.0596205962059621 0.921449662257817 0.686222722051992 0.922195699869012 GO:0000149 SNARE binding 6/1206 106/18639 0.0566037735849057 0.874823993241341 0.689833216429345 0.922195699869012 GO:0008013 beta-catenin binding 6/1206 106/18639 0.0566037735849057 0.874823993241341 0.689833216429345 0.922195699869012 GO:0141003 histone H2AX kinase activity 21/1206 354/18639 0.0593220338983051 0.91683531495067 0.692186792625573 0.922195699869012 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0004706 JUN kinase kinase kinase activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0004970 glutamate-gated receptor activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0008409 5'-3' exonuclease activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0015280 ligand-gated sodium channel activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0015373 monoatomic anion:sodium symporter activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0016854 racemase and epimerase activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0017075 syntaxin-1 binding 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0017128 phospholipid scramblase activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0035615 clathrin adaptor activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/1206 18/18639 0.0555555555555556 0.858623548922056 0.700191036458869 0.922195699869012 GO:0019213 deacetylase activity 2/1206 37/18639 0.0540540540540541 0.835417507059298 0.700699302549421 0.922195699869012 GO:0022829 wide pore channel activity 2/1206 37/18639 0.0540540540540541 0.835417507059298 0.700699302549421 0.922195699869012 GO:0042805 actinin binding 2/1206 37/18639 0.0540540540540541 0.835417507059298 0.700699302549421 0.922195699869012 GO:0070001 aspartic-type peptidase activity 2/1206 37/18639 0.0540540540540541 0.835417507059298 0.700699302549421 0.922195699869012 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/1206 73/18639 0.0547945205479452 0.846861582498467 0.703486133915288 0.922195699869012 GO:0140996 histone H3 kinase activity 21/1206 357/18639 0.0588235294117647 0.909130816505707 0.706616959931307 0.922195699869012 GO:0030170 pyridoxal phosphate binding 3/1206 56/18639 0.0535714285714286 0.82795842217484 0.71128629227649 0.922195699869012 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 3/1206 56/18639 0.0535714285714286 0.82795842217484 0.71128629227649 0.922195699869012 GO:0008017 microtubule binding 16/1206 276/18639 0.0579710144927536 0.895955007570841 0.711502355851276 0.922195699869012 GO:0035064 methylated histone binding 4/1206 74/18639 0.0540540540540541 0.835417507059298 0.713591195308743 0.922195699869012 GO:0042887 amide transmembrane transporter activity 2/1206 38/18639 0.0526315789473684 0.813432835820896 0.714648827186459 0.922195699869012 GO:0099106 ion channel regulator activity 9/1206 160/18639 0.05625 0.869356343283582 0.714735001776768 0.922195699869012 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/1206 19/18639 0.0526315789473684 0.813432835820896 0.71960834004249 0.922195699869012 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/1206 19/18639 0.0526315789473684 0.813432835820896 0.71960834004249 0.922195699869012 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/1206 19/18639 0.0526315789473684 0.813432835820896 0.71960834004249 0.922195699869012 GO:0005520 insulin-like growth factor binding 1/1206 19/18639 0.0526315789473684 0.813432835820896 0.71960834004249 0.922195699869012 GO:0008574 plus-end-directed microtubule motor activity 1/1206 19/18639 0.0526315789473684 0.813432835820896 0.71960834004249 0.922195699869012 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1206 19/18639 0.0526315789473684 0.813432835820896 0.71960834004249 0.922195699869012 GO:0042577 lipid phosphatase activity 1/1206 19/18639 0.0526315789473684 0.813432835820896 0.71960834004249 0.922195699869012 GO:0042800 histone H3K4 methyltransferase activity 1/1206 19/18639 0.0526315789473684 0.813432835820896 0.71960834004249 0.922195699869012 GO:0042834 peptidoglycan binding 1/1206 19/18639 0.0526315789473684 0.813432835820896 0.71960834004249 0.922195699869012 GO:0035173 histone kinase activity 21/1206 360/18639 0.0583333333333333 0.901554726368159 0.720647589162653 0.922195699869012 GO:0070279 vitamin B6 binding 3/1206 57/18639 0.0526315789473684 0.813432835820896 0.722558966410808 0.922195699869012 GO:0019003 GDP binding 4/1206 75/18639 0.0533333333333333 0.824278606965174 0.723441329319901 0.922195699869012 GO:0003730 mRNA 3'-UTR binding 15/1206 262/18639 0.0572519083969466 0.884841061866241 0.7250071496654 0.922195699869012 GO:0106310 protein serine kinase activity 21/1206 361/18639 0.0581717451523546 0.899057344854674 0.725233962803203 0.922195699869012 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/1206 39/18639 0.0512820512820513 0.79257558362036 0.728048042056047 0.922195699869012 GO:0004677 DNA-dependent protein kinase activity 14/1206 246/18639 0.0569105691056911 0.879565586700643 0.728369931270509 0.922195699869012 GO:0140034 methylation-dependent protein binding 4/1206 76/18639 0.0526315789473684 0.813432835820896 0.733037525065123 0.922195699869012 GO:0035402 histone H3T11 kinase activity 14/1206 247/18639 0.0566801619433198 0.876004592422503 0.73378692556455 0.922195699869012 GO:0001972 retinoic acid binding 1/1206 20/18639 0.05 0.772761194029851 0.737769045837804 0.922195699869012 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/1206 20/18639 0.05 0.772761194029851 0.737769045837804 0.922195699869012 GO:0005326 neurotransmitter transmembrane transporter activity 1/1206 20/18639 0.05 0.772761194029851 0.737769045837804 0.922195699869012 GO:0015464 acetylcholine receptor activity 1/1206 20/18639 0.05 0.772761194029851 0.737769045837804 0.922195699869012 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/1206 20/18639 0.05 0.772761194029851 0.737769045837804 0.922195699869012 GO:0061608 nuclear import signal receptor activity 1/1206 20/18639 0.05 0.772761194029851 0.737769045837804 0.922195699869012 GO:0140664 ATP-dependent DNA damage sensor activity 1/1206 20/18639 0.05 0.772761194029851 0.737769045837804 0.922195699869012 GO:0140939 histone H4 methyltransferase activity 1/1206 20/18639 0.05 0.772761194029851 0.737769045837804 0.922195699869012 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/1206 40/18639 0.05 0.772761194029851 0.74090969589445 0.922195699869012 GO:0030331 nuclear estrogen receptor binding 2/1206 40/18639 0.05 0.772761194029851 0.74090969589445 0.922195699869012 GO:0071949 FAD binding 2/1206 40/18639 0.05 0.772761194029851 0.74090969589445 0.922195699869012 GO:0016741 transferase activity, transferring one-carbon groups 12/1206 215/18639 0.0558139534883721 0.862617146824019 0.742230092660247 0.922195699869012 GO:0008276 protein methyltransferase activity 5/1206 95/18639 0.0526315789473684 0.813432835820896 0.743930921900926 0.922195699869012 GO:0017080 sodium channel regulator activity 2/1206 41/18639 0.0487804878048781 0.753913360029123 0.753247192314523 0.922195699869012 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/1206 60/18639 0.05 0.772761194029851 0.754314895310877 0.922195699869012 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1206 60/18639 0.05 0.772761194029851 0.754314895310877 0.922195699869012 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0001846 opsonin binding 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0005248 voltage-gated sodium channel activity 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0008373 sialyltransferase activity 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0015125 bile acid transmembrane transporter activity 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0036122 BMP binding 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0051428 peptide hormone receptor binding 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0140312 cargo adaptor activity 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:1904047 S-adenosyl-L-methionine binding 1/1206 21/18639 0.0476190476190476 0.735963041933191 0.754754411900407 0.922195699869012 GO:0005179 hormone activity 7/1206 132/18639 0.053030303030303 0.819595205789236 0.758028620646247 0.922195699869012 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 7/1206 132/18639 0.053030303030303 0.819595205789236 0.758028620646247 0.922195699869012 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 9/1206 167/18639 0.0538922155688623 0.832916257038163 0.760224796808224 0.922195699869012 GO:0033293 monocarboxylic acid binding 4/1206 79/18639 0.0506329113924051 0.782542981296051 0.76031819762443 0.922195699869012 GO:0004520 DNA endonuclease activity 2/1206 42/18639 0.0476190476190476 0.735963041933191 0.765074451861196 0.922195699869012 GO:0031492 nucleosomal DNA binding 2/1206 42/18639 0.0476190476190476 0.735963041933191 0.765074451861196 0.922195699869012 GO:0008170 N-methyltransferase activity 5/1206 98/18639 0.0510204081632653 0.788531830642705 0.767981220148246 0.922195699869012 GO:0000049 tRNA binding 4/1206 80/18639 0.05 0.772761194029851 0.768916094733369 0.922195699869012 GO:0004407 histone deacetylase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0005243 gap junction channel activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0008093 cytoskeletal anchor activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0031683 G-protein beta/gamma-subunit complex binding 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0032931 histone H3K56 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0033558 protein lysine deacetylase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0034062 5'-3' RNA polymerase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0043992 histone H3K9 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0043993 histone H3K18 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0043994 histone H3K23 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0043999 histone H2AK5 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0044012 histone H2AK9 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0044014 histone H2BK5 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0044015 histone H2BK12 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0044016 histone H3K4 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0044017 histone H3K27 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0044018 histone H3K36 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0046972 histone H4K16 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0097747 RNA polymerase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0140908 histone H3K122 acetyltransferase activity 1/1206 22/18639 0.0454545454545455 0.702510176390773 0.770640445805666 0.922195699869012 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1206 43/18639 0.0465116279069767 0.71884762235335 0.776405789150585 0.922195699869012 GO:0005507 copper ion binding 3/1206 63/18639 0.0476190476190476 0.735963041933191 0.783076330280088 0.922195699869012 GO:0000295 adenine nucleotide transmembrane transporter activity 1/1206 23/18639 0.0434782608695652 0.671966255678131 0.785498243644113 0.922195699869012 GO:0003887 DNA-directed DNA polymerase activity 1/1206 23/18639 0.0434782608695652 0.671966255678131 0.785498243644113 0.922195699869012 GO:0004602 glutathione peroxidase activity 1/1206 23/18639 0.0434782608695652 0.671966255678131 0.785498243644113 0.922195699869012 GO:0017134 fibroblast growth factor binding 1/1206 23/18639 0.0434782608695652 0.671966255678131 0.785498243644113 0.922195699869012 GO:0044013 histone H2B acetyltransferase activity 1/1206 23/18639 0.0434782608695652 0.671966255678131 0.785498243644113 0.922195699869012 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1206 23/18639 0.0434782608695652 0.671966255678131 0.785498243644113 0.922195699869012 GO:0015171 amino acid transmembrane transporter activity 5/1206 102/18639 0.0490196078431373 0.757609013754756 0.797323797949916 0.922195699869012 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/1206 45/18639 0.0444444444444444 0.686898839137645 0.797639283337559 0.922195699869012 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 13/1206 243/18639 0.0534979423868313 0.826822676739758 0.798420612008357 0.922195699869012 GO:0005315 phosphate transmembrane transporter activity 1/1206 24/18639 0.0416666666666667 0.643967661691542 0.799394307146756 0.922195699869012 GO:0015295 solute:proton symporter activity 1/1206 24/18639 0.0416666666666667 0.643967661691542 0.799394307146756 0.922195699869012 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1206 24/18639 0.0416666666666667 0.643967661691542 0.799394307146756 0.922195699869012 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1206 24/18639 0.0416666666666667 0.643967661691542 0.799394307146756 0.922195699869012 GO:0043998 histone H2A acetyltransferase activity 1/1206 24/18639 0.0416666666666667 0.643967661691542 0.799394307146756 0.922195699869012 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1206 24/18639 0.0416666666666667 0.643967661691542 0.799394307146756 0.922195699869012 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1206 24/18639 0.0416666666666667 0.643967661691542 0.799394307146756 0.922195699869012 GO:0070840 dynein complex binding 1/1206 24/18639 0.0416666666666667 0.643967661691542 0.799394307146756 0.922195699869012 GO:0140612 DNA damage sensor activity 1/1206 24/18639 0.0416666666666667 0.643967661691542 0.799394307146756 0.922195699869012 GO:0140767 enzyme-substrate adaptor activity 7/1206 139/18639 0.0503597122302158 0.778320627080425 0.802755913740303 0.922195699869012 GO:0005543 phospholipid binding 28/1206 497/18639 0.0563380281690141 0.870716838343494 0.803605649235717 0.922195699869012 GO:0004676 3-phosphoinositide-dependent protein kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0004711 ribosomal protein S6 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0035175 histone H3S10 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0035979 histone H2AXS139 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0044022 histone H3S28 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0044023 histone H4S1 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0044024 histone H2AS1 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0044025 histone H2BS14 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0072354 histone H3T3 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0072371 histone H2AS121 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0072518 Rho-dependent protein serine/threonine kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0140823 histone H2BS36 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0140855 histone H3S57 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0140995 histone H2A kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0140997 histone H4 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0140998 histone H2B kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:1990244 histone H2AT120 kinase activity 13/1206 245/18639 0.0530612244897959 0.820073103868413 0.807472633414166 0.922195699869012 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/1206 46/18639 0.0434782608695652 0.671966255678131 0.807571118599673 0.922195699869012 GO:0030276 clathrin binding 2/1206 46/18639 0.0434782608695652 0.671966255678131 0.807571118599673 0.922195699869012 GO:0140857 histone H3T45 kinase activity 13/1206 246/18639 0.0528455284552846 0.816739473364883 0.811886088898576 0.922195699869012 GO:0000030 mannosyltransferase activity 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0001848 complement binding 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0003707 nuclear steroid receptor activity 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0004709 MAP kinase kinase kinase activity 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0005537 D-mannose binding 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0015645 fatty acid ligase activity 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0015662 P-type ion transporter activity 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0017025 TBP-class protein binding 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0019707 protein-cysteine S-acyltransferase activity 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0120515 fatty acid-CoA ligase activity 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0140358 P-type transmembrane transporter activity 1/1206 25/18639 0.04 0.618208955223881 0.812390840350141 0.922195699869012 GO:0051020 GTPase binding 17/1206 315/18639 0.053968253968254 0.834091447524283 0.813545048119076 0.922568343907623 GO:0035403 histone H3T6 kinase activity 13/1206 247/18639 0.0526315789473684 0.813432835820896 0.816224931306022 0.924668608791913 GO:0140938 histone H3 methyltransferase activity 2/1206 47/18639 0.0425531914893617 0.657669101302001 0.817066227792682 0.924683866711678 GO:0004679 AMP-activated protein kinase activity 13/1206 248/18639 0.0524193548387097 0.810152864708715 0.820489520533002 0.925914006474231 GO:0004497 monooxygenase activity 5/1206 106/18639 0.0471698113207547 0.729019994367784 0.823667298780174 0.925914006474231 GO:0008066 glutamate receptor activity 1/1206 26/18639 0.0384615384615385 0.59443168771527 0.824546027120192 0.925914006474231 GO:0015216 purine nucleotide transmembrane transporter activity 1/1206 26/18639 0.0384615384615385 0.59443168771527 0.824546027120192 0.925914006474231 GO:0051139 metal cation:proton antiporter activity 1/1206 26/18639 0.0384615384615385 0.59443168771527 0.824546027120192 0.925914006474231 GO:0120014 phospholipid transfer activity 1/1206 26/18639 0.0384615384615385 0.59443168771527 0.824546027120192 0.925914006474231 GO:0003777 microtubule motor activity 3/1206 68/18639 0.0441176470588235 0.68184811237928 0.824784634236222 0.925914006474231 GO:0140223 general transcription initiation factor activity 3/1206 68/18639 0.0441176470588235 0.68184811237928 0.824784634236222 0.925914006474231 GO:0032266 phosphatidylinositol-3-phosphate binding 2/1206 48/18639 0.0416666666666667 0.643967661691542 0.826139491020039 0.926503826776489 GO:0016279 protein-lysine N-methyltransferase activity 3/1206 69/18639 0.0434782608695652 0.671966255678131 0.832251546683877 0.931487953552997 GO:0098960 postsynaptic neurotransmitter receptor activity 3/1206 69/18639 0.0434782608695652 0.671966255678131 0.832251546683877 0.931487953552997 GO:0001222 transcription corepressor binding 2/1206 49/18639 0.0408163265306122 0.630825464514164 0.834805692729667 0.931852557673493 GO:0004843 cysteine-type deubiquitinase activity 5/1206 108/18639 0.0462962962962963 0.715519624101714 0.835763215742666 0.931852557673493 GO:0005104 fibroblast growth factor receptor binding 1/1206 27/18639 0.037037037037037 0.572415699281371 0.835914290768881 0.931852557673493 GO:0016405 CoA-ligase activity 1/1206 27/18639 0.037037037037037 0.572415699281371 0.835914290768881 0.931852557673493 GO:0016278 lysine N-methyltransferase activity 3/1206 70/18639 0.0428571428571429 0.662366737739872 0.83944319179034 0.934455450862062 GO:0015081 sodium ion transmembrane transporter activity 8/1206 164/18639 0.0487804878048781 0.753913360029123 0.83992235690735 0.934455450862062 GO:0016866 intramolecular transferase activity 1/1206 28/18639 0.0357142857142857 0.551972281449893 0.846546536918286 0.936193447509908 GO:0036408 histone H3K14 acetyltransferase activity 1/1206 28/18639 0.0357142857142857 0.551972281449893 0.846546536918286 0.936193447509908 GO:0050698 proteoglycan sulfotransferase activity 1/1206 28/18639 0.0357142857142857 0.551972281449893 0.846546536918286 0.936193447509908 GO:0051393 alpha-actinin binding 1/1206 28/18639 0.0357142857142857 0.551972281449893 0.846546536918286 0.936193447509908 GO:0008237 metallopeptidase activity 9/1206 184/18639 0.0489130434782609 0.755962037637897 0.848713129676824 0.936193447509908 GO:0005272 sodium channel activity 2/1206 51/18639 0.0392156862745098 0.606087211003804 0.850975278628049 0.936193447509908 GO:1902936 phosphatidylinositol bisphosphate binding 5/1206 111/18639 0.045045045045045 0.696181255882748 0.852625325192066 0.936193447509908 GO:1901981 phosphatidylinositol phosphate binding 9/1206 185/18639 0.0486486486486487 0.751875756353368 0.852992748731312 0.936193447509908 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 6/1206 130/18639 0.0461538461538462 0.713318025258324 0.853329951779895 0.936193447509908 GO:0016874 ligase activity 8/1206 167/18639 0.0479041916167665 0.740370006256144 0.853680210294832 0.936193447509908 GO:0052689 carboxylic ester hydrolase activity 4/1206 92/18639 0.0434782608695652 0.671966255678131 0.854083611201216 0.936193447509908 GO:0003785 actin monomer binding 1/1206 29/18639 0.0344827586206897 0.532938754503345 0.856490380692213 0.936193447509908 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/1206 29/18639 0.0344827586206897 0.532938754503345 0.856490380692213 0.936193447509908 GO:0010484 histone H3 acetyltransferase activity 1/1206 29/18639 0.0344827586206897 0.532938754503345 0.856490380692213 0.936193447509908 GO:0016417 S-acyltransferase activity 1/1206 29/18639 0.0344827586206897 0.532938754503345 0.856490380692213 0.936193447509908 GO:0043236 laminin binding 1/1206 29/18639 0.0344827586206897 0.532938754503345 0.856490380692213 0.936193447509908 GO:0097472 cyclin-dependent protein kinase activity 1/1206 29/18639 0.0344827586206897 0.532938754503345 0.856490380692213 0.936193447509908 GO:0008168 methyltransferase activity 10/1206 204/18639 0.0490196078431373 0.757609013754756 0.857000793643418 0.936193447509908 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/1206 52/18639 0.0384615384615385 0.59443168771527 0.858507337997288 0.936193447509908 GO:0042562 hormone binding 4/1206 94/18639 0.0425531914893617 0.657669101302001 0.86532317775751 0.936193447509908 GO:0003684 damaged DNA binding 3/1206 74/18639 0.0405405405405405 0.626563130294474 0.865600952513355 0.936193447509908 GO:0005544 calcium-dependent phospholipid binding 2/1206 53/18639 0.0377358490566038 0.583215995494227 0.865689618018857 0.936193447509908 GO:0016251 RNA polymerase II general transcription initiation factor activity 2/1206 53/18639 0.0377358490566038 0.583215995494227 0.865689618018857 0.936193447509908 GO:0017046 peptide hormone binding 2/1206 53/18639 0.0377358490566038 0.583215995494227 0.865689618018857 0.936193447509908 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1206 53/18639 0.0377358490566038 0.583215995494227 0.865689618018857 0.936193447509908 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/1206 53/18639 0.0377358490566038 0.583215995494227 0.865689618018857 0.936193447509908 GO:0043995 histone H4K5 acetyltransferase activity 1/1206 30/18639 0.0333333333333333 0.515174129353234 0.865790359245958 0.936193447509908 GO:0043996 histone H4K8 acetyltransferase activity 1/1206 30/18639 0.0333333333333333 0.515174129353234 0.865790359245958 0.936193447509908 GO:0043997 histone H4K12 acetyltransferase activity 1/1206 30/18639 0.0333333333333333 0.515174129353234 0.865790359245958 0.936193447509908 GO:0015485 cholesterol binding 2/1206 54/18639 0.037037037037037 0.572415699281371 0.872535803672191 0.939233886401452 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/1206 54/18639 0.037037037037037 0.572415699281371 0.872535803672191 0.939233886401452 GO:0101005 deubiquitinase activity 5/1206 115/18639 0.0434782608695652 0.671966255678131 0.872843339683802 0.939233886401452 GO:0005452 solute:inorganic anion antiporter activity 1/1206 31/18639 0.032258064516129 0.498555609051517 0.874488130579687 0.939233886401452 GO:0008327 methyl-CpG binding 1/1206 31/18639 0.032258064516129 0.498555609051517 0.874488130579687 0.939233886401452 GO:0016878 acid-thiol ligase activity 1/1206 31/18639 0.032258064516129 0.498555609051517 0.874488130579687 0.939233886401452 GO:0017147 Wnt-protein binding 1/1206 31/18639 0.032258064516129 0.498555609051517 0.874488130579687 0.939233886401452 GO:0044325 transmembrane transporter binding 6/1206 136/18639 0.0441176470588235 0.68184811237928 0.880784142999583 0.944338611766105 GO:0031267 small GTPase binding 14/1206 283/18639 0.049469964664311 0.764569379252149 0.882590983834494 0.944338611766105 GO:0015106 bicarbonate transmembrane transporter activity 1/1206 32/18639 0.03125 0.482975746268657 0.882622659519976 0.944338611766105 GO:0140142 nucleocytoplasmic carrier activity 1/1206 32/18639 0.03125 0.482975746268657 0.882622659519976 0.944338611766105 GO:0035091 phosphatidylinositol binding 14/1206 284/18639 0.0492957746478873 0.761877233550557 0.885512511900316 0.946523900280051 GO:0004252 serine-type endopeptidase activity 8/1206 176/18639 0.0454545454545455 0.702510176390773 0.889327958675995 0.948842888860316 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/1206 33/18639 0.0303030303030303 0.468340117593849 0.890230391697055 0.948842888860316 GO:0019239 deaminase activity 1/1206 33/18639 0.0303030303030303 0.468340117593849 0.890230391697055 0.948842888860316 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/1206 57/18639 0.0350877192982456 0.54228855721393 0.891189966342521 0.948960145285601 GO:0016835 carbon-oxygen lyase activity 3/1206 79/18639 0.0379746835443038 0.586907235972039 0.89296738327856 0.949947206783001 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/1206 34/18639 0.0294117647058824 0.454565408252853 0.89734541629199 0.953696317790821 GO:0008238 exopeptidase activity 4/1206 102/18639 0.0392156862745098 0.606087211003804 0.903137996458797 0.955314639183211 GO:0010485 histone H4 acetyltransferase activity 1/1206 35/18639 0.0285714285714286 0.441577825159915 0.903999618278115 0.955314639183211 GO:0034061 DNA polymerase activity 1/1206 35/18639 0.0285714285714286 0.441577825159915 0.903999618278115 0.955314639183211 GO:0043015 gamma-tubulin binding 1/1206 35/18639 0.0285714285714286 0.441577825159915 0.903999618278115 0.955314639183211 GO:0061631 ubiquitin conjugating enzyme activity 1/1206 35/18639 0.0285714285714286 0.441577825159915 0.903999618278115 0.955314639183211 GO:0140566 histone reader activity 1/1206 35/18639 0.0285714285714286 0.441577825159915 0.903999618278115 0.955314639183211 GO:0005484 SNAP receptor activity 1/1206 36/18639 0.0277777777777778 0.429311774461028 0.910222820834371 0.960074495629833 GO:0016409 palmitoyltransferase activity 1/1206 36/18639 0.0277777777777778 0.429311774461028 0.910222820834371 0.960074495629833 GO:0016836 hydro-lyase activity 2/1206 61/18639 0.0327868852459016 0.506728651822853 0.912130167881602 0.961178676909198 GO:0030280 structural constituent of skin epidermis 1/1206 37/18639 0.027027027027027 0.417708753529649 0.916042918564509 0.963763917942653 GO:0019783 ubiquitin-like protein peptidase activity 5/1206 127/18639 0.0393700787401575 0.608473381125867 0.919921365491542 0.963763917942653 GO:0022824 transmitter-gated monoatomic ion channel activity 2/1206 63/18639 0.0317460317460317 0.490642027955461 0.921123180035488 0.963763917942653 GO:0022835 transmitter-gated channel activity 2/1206 63/18639 0.0317460317460317 0.490642027955461 0.921123180035488 0.963763917942653 GO:1901682 sulfur compound transmembrane transporter activity 2/1206 63/18639 0.0317460317460317 0.490642027955461 0.921123180035488 0.963763917942653 GO:0000146 microfilament motor activity 1/1206 38/18639 0.0263157894736842 0.406716417910448 0.921486002115267 0.963763917942653 GO:0005501 retinoid binding 1/1206 38/18639 0.0263157894736842 0.406716417910448 0.921486002115267 0.963763917942653 GO:0019840 isoprenoid binding 1/1206 38/18639 0.0263157894736842 0.406716417910448 0.921486002115267 0.963763917942653 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 3/1206 86/18639 0.0348837209302326 0.539135716765012 0.9228822962822 0.964321351681214 GO:0005496 steroid binding 4/1206 108/18639 0.037037037037037 0.572415699281371 0.925005752670001 0.965029256648464 GO:0004536 DNA nuclease activity 2/1206 64/18639 0.03125 0.482975746268657 0.925287675801705 0.965029256648464 GO:0160215 deacylase activity 2/1206 65/18639 0.0307692307692308 0.475545350172216 0.929244054430702 0.966953535295211 GO:0071855 neuropeptide receptor binding 1/1206 40/18639 0.025 0.386380597014925 0.931337161385685 0.966953535295211 GO:0008235 metalloexopeptidase activity 2/1206 66/18639 0.0303030303030303 0.468340117593849 0.933001784735049 0.966953535295211 GO:0015291 secondary active transmembrane transporter activity 13/1206 287/18639 0.0452961672473868 0.700062405741328 0.93532377132534 0.966953535295211 GO:0004812 aminoacyl-tRNA ligase activity 1/1206 41/18639 0.024390243902439 0.376956680014561 0.935789410612464 0.966953535295211 GO:0008227 G protein-coupled amine receptor activity 1/1206 41/18639 0.024390243902439 0.376956680014561 0.935789410612464 0.966953535295211 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/1206 41/18639 0.024390243902439 0.376956680014561 0.935789410612464 0.966953535295211 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/1206 41/18639 0.024390243902439 0.376956680014561 0.935789410612464 0.966953535295211 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/1206 41/18639 0.024390243902439 0.376956680014561 0.935789410612464 0.966953535295211 GO:0140828 metal cation:monoatomic cation antiporter activity 1/1206 41/18639 0.024390243902439 0.376956680014561 0.935789410612464 0.966953535295211 GO:0008236 serine-type peptidase activity 8/1206 194/18639 0.0412371134020619 0.637328819818434 0.939169051885592 0.969466699318706 GO:0032934 sterol binding 2/1206 68/18639 0.0294117647058824 0.454565408252853 0.939957417513123 0.969466699318706 GO:0043178 alcohol binding 3/1206 92/18639 0.0326086956521739 0.503974691758598 0.94220763710682 0.970891079933873 GO:0017171 serine hydrolase activity 8/1206 198/18639 0.0404040404040404 0.624453490125132 0.94709869908344 0.975031563941201 GO:0140101 catalytic activity, acting on a tRNA 5/1206 139/18639 0.0359712230215827 0.555943305057446 0.950884685266497 0.978027802433405 GO:0004180 carboxypeptidase activity 1/1206 46/18639 0.0217391304347826 0.335983127839066 0.954079471484013 0.980221202274006 GO:0030594 neurotransmitter receptor activity 3/1206 97/18639 0.0309278350515464 0.477996614863825 0.954772308034126 0.980221202274006 GO:0099095 ligand-gated monoatomic anion channel activity 1/1206 47/18639 0.0212765957446809 0.328834550651 0.957058020259911 0.981665572663288 GO:0017022 myosin binding 2/1206 76/18639 0.0263157894736842 0.406716417910448 0.96149301881503 0.985309818363659 GO:0008146 sulfotransferase activity 1/1206 53/18639 0.0188679245283019 0.291607997747113 0.971285640054438 0.994432685555277 GO:0016798 hydrolase activity, acting on glycosyl bonds 4/1206 130/18639 0.0307692307692308 0.475545350172216 0.972187787784262 0.994444834207894 GO:0050661 NADP binding 1/1206 54/18639 0.0185185185185185 0.286207849640685 0.97314884451448 0.994517163149748 GO:0099094 ligand-gated monoatomic cation channel activity 4/1206 136/18639 0.0294117647058824 0.454565408252853 0.979045191745047 0.99962840875614 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/1206 91/18639 0.021978021978022 0.339675250123011 0.983602889489462 0.999999469061999 GO:0015103 inorganic anion transmembrane transporter activity 5/1206 165/18639 0.0303030303030303 0.468340117593849 0.98420019209502 0.999999469061999 GO:0015108 chloride transmembrane transporter activity 3/1206 121/18639 0.0247933884297521 0.383187368940422 0.986734645887811 0.999999469061999 GO:0008509 monoatomic anion transmembrane transporter activity 4/1206 149/18639 0.0268456375838926 0.41490533907643 0.988828013793271 0.999999469061999 GO:0016782 transferase activity, transferring sulphur-containing groups 1/1206 70/18639 0.0142857142857143 0.220788912579957 0.990825893873604 0.999999469061999 GO:0005253 monoatomic anion channel activity 2/1206 103/18639 0.0194174757281553 0.300101434574699 0.99184574308597 0.999999469061999 GO:0015297 antiporter activity 3/1206 135/18639 0.0222222222222222 0.343449419568823 0.993710795819926 0.999999469061999 GO:0022834 ligand-gated channel activity 5/1206 188/18639 0.0265957446808511 0.41104318831375 0.994594150606552 0.999999469061999 GO:0005254 chloride channel activity 1/1206 83/18639 0.0120481927710843 0.186207516633699 0.996169034617763 0.999999469061999 GO:0015276 ligand-gated monoatomic ion channel activity 4/1206 186/18639 0.021505376344086 0.332370406034344 0.998304205163681 0.999999469061999 GO:0015079 potassium ion transmembrane transporter activity 3/1206 160/18639 0.01875 0.289785447761194 0.998410680518188 0.999999469061999 GO:0030527 structural constituent of chromatin 1/1206 98/18639 0.0102040816326531 0.157706366128541 0.998602460649046 0.999999469061999 GO:0008528 G protein-coupled peptide receptor activity 1/1206 122/18639 0.00819672131147541 0.126682162955713 0.999722098750954 0.999999469061999 GO:0005267 potassium channel activity 1/1206 124/18639 0.00806451612903226 0.124638902262879 0.999757119904869 0.999999469061999 GO:0001653 peptide receptor activity 1/1206 128/18639 0.0078125 0.120743936567164 0.999814486651997 0.999999469061999 GO:0046873 metal ion transmembrane transporter activity 13/1206 450/18639 0.0288888888888889 0.446484245439469 0.999823499797408 0.999999469061999 GO:0005261 monoatomic cation channel activity 8/1206 341/18639 0.0234604105571848 0.362585897492012 0.999881296939739 0.999999469061999 GO:0022832 voltage-gated channel activity 2/1206 175/18639 0.0114285714285714 0.176631130063966 0.999896967797377 0.999999469061999 GO:0022836 gated channel activity 6/1206 318/18639 0.0188679245283019 0.291607997747113 0.999972461124867 0.999999469061999 GO:0005244 voltage-gated monoatomic ion channel activity 1/1206 173/18639 0.00578034682080925 0.0893365542231041 0.99999108479561 0.999999469061999 GO:0045182 translation regulator activity 6/1206 356/18639 0.0168539325842697 0.260481301358377 0.999996417016823 0.999999469061999 GO:0005216 monoatomic ion channel activity 9/1206 448/18639 0.0200892857142857 0.310484408315565 0.999997905701284 0.999999469061999 GO:0030371 translation repressor activity 4/1206 329/18639 0.0121580547112462 0.187905457514857 0.999999469061999 0.999999469061999