category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	136/1123	222/9376	5.11474252525009	RPS4Y1/RPS10/RPSA/RACK1/RPL27/RPL10A/RPL23/RPS2/RPL31/RPL26/RPL23A/RPS20/RPLP0/RPS11/RPL27A/RPS5/RPS3/RPS15A/RPS16/RPL7/RPL18A/RPL29/UBA52/RPL13A/RPS7/RPL18/RPL24/RPL13/RPS6/RPS24/RPLP2/RPL3/RPL32/RPS13/RPL14/RPS23/RPS14/RPL19/RPL11/RPL8/RPS15/RPL15/RPS19/RPS3A/RPS8/RPLP1/RPL30/RPS27A/RPL28/RPL10/RPS12/RPL36A/RPS4X/RPL9/RPL12/RPL21/RPL6/RPL39/RPL5/RPS29/RPS28/RPS27/RPL22/RPL4/RPL34/RPS26/RPL37/RPL35/RPL17/RPL35A/FAU/RPL41/RPL38/MRPL4/RPL36/RPL37A/MRPL27/MRPL11/MRPS25/MRPL15/MRPS15/MRPL12/RPS21/MRPL16/MRPS2/MRPS26/MRPL21/MRPS28/MRPS7/RPS9/RPL22L1/RPS18/RPL7A/MRPL44/MRPL17/MRPS17/RPS17/MRPL13/MRPS35/RPS25/MRPL34/MRPS33/MRPS6/MRPL10/MRPL40/MRPS22/RPL26L1/MRPS16/MRPL2/MRPL39/MRPS34/MRPS10/MRPS18C/MRPL52/MRPL46/MRPL22/MRPL51/MRPL36/MRPL38/MRPL50/MRPL14/MRPS14/MRPS12/MRPL48/MRPS21/MRPL9/MRPL3/MRPL24/RPL36AL/MRPL37/MRPL35/MRPL47/MRPS11/DAP3/MRPL49/MRPL20	22.8867060621147
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	117/1123	268/9376	3.64492763254077	SLC25A5/SLC25A6/ATP5MC3/GNAS/UBA52/RPS27A/UBB/PPIF/ATP5F1B/COX4I1/PSMB1/NDUFA11/ATP5F1C/ATP5PO/ATP5F1A/PSMB4/PSMB2/UQCRH/COX5A/PARK7/PSMA1/PSMB6/ATP5MC1/UQCR10/ATP5MC2/ATP5PB/CYC1/PSMA7/PSMA4/COX5B/COX7B/TUBA1C/PSMA5/SDHD/UQCRFS1/TUBA1B/COX6C/SEM1/COX8A/PSMA3/NDUFS8/NDUFB8/SOD1/UQCRC2/ATP5PF/PSMD11/COX7C/PSMB7/PSMD7/TXN2/ADRM1/NDUFA10/NDUFA4/PSMD4/UQCRQ/PSMC1/NDUFB9/VDAC1/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/PSMB5/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/CYCS/NDUFB5/UBE2L3/NDUFB10/PSMD13/NDUFS6/UQCRB/NDUFS7/NDUFS5/PSMD6/PSMD14/COX6B1/CALM3/NDUFV1/NDUFB4/NDUFA8/PSMC3/PSMD3/SLC39A1/UQCR11/NDUFA2/TUBB/SDHB/NDUFB6/NDUFB3/VDAC3/BAX/PSMD8/COX6A1/PSMC2/NDUFA9/COX4I2/NDUFA6/NDUFB2/PSMA2/PSMC5/PSMB3/NDUFA12/TUBB4B/PSMA6/NDUFS2/TRAP1/PSMD2/PSMC4/NDUFA1/SLC25A4/TP53/DAXX/NDUFS3	16.204635762692
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	116/1123	275/9376	3.5217874200599	SLC25A5/SLC25A6/ATP5MC3/PPIF/ATP5F1B/COX4I1/PSMB1/NDUFA11/ATP5F1C/ATP5PO/ATP5F1A/PSMB4/PSMB2/UQCRH/COX5A/PSMA1/PSMB6/ATP5MC1/UQCR10/ATP5MC2/ATP5PB/CYC1/PSMA7/PSMA4/COX5B/COX7B/TUBA1C/PSMA5/SDHD/UQCRFS1/TUBA1B/COX6C/HSPA8/SEM1/COX8A/PSMA3/NDUFS8/NDUFB8/SOD1/UQCRC2/ATP5PF/PSMD11/COX7C/PSMB7/PSMD7/ADRM1/NDUFA10/NDUFA4/PSMD4/UQCRQ/C1QA/PSMC1/NDUFB9/VDAC1/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/PSMB5/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/CYCS/NDUFB5/NDUFB10/PSMD13/NDUFS6/UQCRB/NDUFS7/C1QB/NDUFS5/PSMD6/C1QC/PSMD14/COX6B1/NDUFV1/NDUFB4/NDUFA8/PSMC3/PSMD3/UQCR11/NDUFA2/TUBB/SDHB/NDUFB6/NDUFB3/VDAC3/BAX/PSMD8/COX6A1/PSMC2/NDUFA9/COX4I2/NDUFA6/NDUFB2/PSMA2/PSMC5/CSNK2B/PSMB3/NDUFA12/TUBB4B/PSMA6/NDUFS2/MAPK13/CYBB/STIP1/PSMD2/CYBA/PSMC4/NDUFA1/HSPA6/SLC25A4/RYR1/NDUFS3	15.6566865652697
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	120/1123	308/9376	3.25288246926715	SLC25A5/SLC25A6/ATP5MC3/PPIF/ATP5F1B/GPX3/COX4I1/PSMB1/NDUFA11/ATP5F1C/ATP5PO/CLTA/ATP5F1A/PSMB4/PSMB2/UQCRH/COX5A/PSMA1/PSMB6/ATP5MC1/UQCR10/ATP5MC2/ATP5PB/CYC1/PSMA7/PSMA4/COX5B/COX7B/TUBA1C/PSMA5/SDHD/UQCRFS1/TUBA1B/COX6C/AP2M1/SEM1/COX8A/PSMA3/NDUFS8/NDUFB8/SOD1/UQCRC2/ATP5PF/PSMD11/COX7C/PSMB7/PSMD7/ADRM1/NDUFA10/NDUFA4/PSMD4/UQCRQ/PSMC1/NDUFB9/VDAC1/NDUFAB1/NDUFA13/NDUFC2/POLR2E/NDUFA7/PSMB5/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/CYCS/NDUFB5/TGM2/NDUFB10/PSMD13/TFAM/NDUFS6/UQCRB/NDUFS7/NDUFS5/PSMD6/PSMD14/COX6B1/POLR2F/PPARG/NDUFV1/POLR2G/NDUFB4/POLR2H/POLR2J/NDUFA8/PSMC3/PSMD3/UQCR11/NDUFA2/TUBB/SDHB/NDUFB6/NDUFB3/VDAC3/HDAC1/BAX/PSMD8/COX6A1/AMBRA1/PSMC2/NDUFA9/COX4I2/NDUFA6/NDUFB2/PSMA2/PSMC5/PSMB3/NDUFA12/TUBB4B/PSMA6/NDUFS2/PSMD2/PSMC4/NDUFA1/POLR2L/SLC25A4/TP53/NDUFS3	14.8295417790417
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	102/1123	238/9376	3.57817071619387	RPS4Y1/RPS10/RPSA/RPL27/RPL10A/RPL23/RPS2/RPL31/RPL26/RPL23A/RPS20/RPLP0/RPS11/RPL27A/RPS5/RPS3/RPS15A/RPS16/RPL7/RPL18A/RPL29/UBA52/RPL13A/RPS7/RPL18/RPL24/RPL13/RPS6/RPS24/RPLP2/RPL3/RPL32/RPS13/RPL14/RPS23/RPS14/RPL19/RPL11/RPL8/RPS15/RPL15/RPS19/RPS3A/RPS8/RPLP1/RPL30/RPS27A/RPL28/RPL10/RPS12/RPL36A/RPS4X/RPL9/RPL12/RPL21/RPL6/RPL39/RPL5/RPS29/RPS28/RPS27/RPL22/RPL4/RPL34/RPS26/RPL37/RPL35/RPL17/RPL35A/FAU/RPL41/RPL38/RPL36/RPL37A/C1QA/RPS21/F13A1/C1QB/RPS9/C1QC/RPL22L1/RPS18/RPL7A/RPS17/RPS25/NFKBIA/RPL26L1/FCGR2A/C3AR1/MAPK13/PLCG2/CYBB/RPL36AL/TLR3/CASP1/TLR7/MX2/CFB/CXCL8/C2/TLR4/OAS3	14.8608676591554
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	75/1123	138/9376	4.53753532850672	ATP5MC3/ATP5MG/ATP5F1B/COX4I1/NDUFA11/ATP5F1C/ATP5PO/ATP5F1A/UQCRH/COX5A/ATP5MC1/UQCR10/ATP5MC2/ATP5PB/CYC1/COX5B/COX7B/SDHD/ATP6V1C2/UQCRFS1/COX6C/COX8A/NDUFS8/NDUFB8/UQCRC2/ATP5PF/PPA1/COX7C/NDUFA10/ATP5MF/NDUFA4/UQCRQ/NDUFB9/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/CYCS/NDUFB5/NDUFB10/NDUFS6/UQCRB/NDUFS7/NDUFS5/COX6B1/NDUFV1/NDUFB4/NDUFA8/UQCR11/NDUFA2/SDHB/NDUFB6/NDUFB3/COX6A1/ATP6V1B2/NDUFA9/ATP6V0A4/COX4I2/NDUFA6/NDUFB2/NDUFA12/NDUFS2/ATP6V0C/ATP6V1B1/PPA2/COX10/NDUFA1/ATP6V0D1/ATP6V0E2/NDUFS3	15.4426185411634
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	124/1123	368/9376	2.81327190367416	ATP5MC3/HNRNPA1/PFN1/ATP5F1B/GPX3/COX4I1/PSMB1/NDUFA11/ATP5F1C/ATP5PO/ATP5F1A/HNRNPA2B1/PSMB4/PSMB2/UQCRH/COX5A/PSMA1/PSMB6/ATP5MC1/UQCR10/ATP5MC2/HNRNPA3/ATP5PB/SRSF3/CYC1/PSMA7/PSMA4/COX5B/COX7B/TUBA1C/PSMA5/SDHD/UQCRFS1/TUBA1B/COX6C/SEM1/COX8A/PSMA3/NDUFS8/NDUFB8/SOD1/UQCRC2/ATP5PF/PSMD11/COX7C/PSMB7/PSMD7/ADRM1/NDUFA10/NDUFA4/PSMD4/UQCRQ/PSMC1/NDUFB9/VDAC1/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/PSMB5/HNRNPA1L3/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/CYCS/NDUFB5/NDUFB10/PSMD13/ALYREF/CAT/TOMM40/NDUFS6/UQCRB/NDUFS7/SRSF7/NDUFS5/PSMD6/VCP/PSMD14/COX6B1/NDUFV1/NDUFB4/NDUFA8/PSMC3/PSMD3/UQCR11/NDUFA2/TUBB/SDHB/NDUFB6/NDUFB3/BAX/PSMD8/COX6A1/RAB8A/NUP37/AMBRA1/PSMC2/NDUFA9/NXT1/CHCHD10/COX4I2/NDUFA6/BID/NDUFB2/PSMA2/PSMC5/PSMB3/NDUFA12/TUBB4B/PSMA6/NDUFS2/MAPK13/PSMD2/CASP1/PSMC4/NDUFA1/NUP85/ANXA7/TP53/DAXX/NDUFS3	13.0900783692889
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	84/1123	205/9376	3.42108029450731	SLC25A5/SLC25A6/ATP5MC3/PPIF/ATP5F1B/COX4I1/PARP1/NDUFA11/ATP5F1C/ATP5PO/ATP5F1A/UQCRH/COX5A/ATP5MC1/UQCR10/ATP5MC2/ATP5PB/CYC1/COX5B/COX7B/SDHD/UQCRFS1/COX6C/COX8A/NDUFS8/NDUFB8/UQCRC2/ATP5PF/COX7C/NDUFA10/NDUFA4/UQCRQ/NDUFB9/VDAC1/CPT2/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/NDUFB5/MPC2/NDUFB10/GAPDH/NDUFS6/UQCRB/NDUFS7/PPP1CA/NDUFS5/COX6B1/NDUFV1/NDUFB4/NDUFA8/GSR/UQCR11/NDUFA2/SDHB/PPP1CC/NDUFB6/NDUFB3/VDAC3/COX6A1/NDUFA9/COX4I2/NDUFA6/PDHB/NDUFB2/NDUFA12/PDHA1/NDUFS2/MAPK13/PRKCZ/CYBB/PDK3/CYBA/NDUFA1/AKT3/SLC25A4/AKT1/NDUFS3	12.9284771005183
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	87/1123	227/9376	3.19986191800597	SLC25A5/SLC25A6/ATP5MC3/MGST3/PPIF/ATP5F1B/COX4I1/NDUFA11/ATP5F1C/ATP5PO/ATP5F1A/UQCRH/COX5A/GSTO1/GSTA4/ATP5MC1/UQCR10/ATP5MC2/ATP5PB/CYC1/GSTA3/COX5B/COX7B/SDHD/UQCRFS1/COX6C/COX8A/NDUFS8/NDUFB8/SOD1/UQCRC2/ATP5PF/COX7C/NDUFA10/GSTT1/NDUFA4/UQCRQ/NDUFB9/VDAC1/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/NDUFB5/NDUFB10/CAT/NDUFS6/UQCRB/NDUFS7/NDUFS5/COX6B1/NDUFV1/NDUFB4/EPHX2/NDUFA8/UQCR11/NDUFA2/SDHB/NDUFB6/NDUFB3/VDAC3/NFKBIA/AKR1A1/COX6A1/NDUFA9/COX4I2/NDUFA6/CBR1/NDUFB2/NDUFA12/HMOX1/NDUFS2/EPHX1/MAPK13/MAP2K2/PLD2/CYBA/NDUFA1/AKT3/SLC25A4/AKT1/NDUFS3	12.3763086114633
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	119/1123	388/9376	2.56066684414905	SLC25A5/SLC25A6/ATP5MC3/PPIF/ATP5F1B/COX4I1/PSMB1/NDUFA11/ATP5F1C/ATP5PO/ATP5F1A/PSMB4/PSMB2/UQCRH/COX5A/PSMA1/PSMB6/ATP5MC1/UQCR10/ATP5MC2/ATP5PB/CYC1/PSMA7/PSMA4/COX5B/COX7B/TUBA1C/PSMA5/SDHD/UQCRFS1/TUBA1B/COX6C/SEM1/COX8A/PSMA3/NDUFS8/NDUFB8/UQCRC2/ATP5PF/PSMD11/COX7C/PSMB7/PSMD7/ADRM1/NDUFA10/NDUFA4/PSMD4/UQCRQ/PSMC1/NDUFB9/VDAC1/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/PSMB5/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/CYCS/NDUFB5/NDUFB10/PSMD13/HSD17B10/GAPDH/NDUFS6/UQCRB/NDUFS7/NDUFS5/PSMD6/PSMD14/COX6B1/CALM3/NDUFV1/NDUFB4/NDUFA8/BACE2/PSMC3/PSMD3/SLC39A1/UQCR11/NDUFA2/TUBB/SDHB/NDUFB6/NDUFB3/VDAC3/PSMD8/COX6A1/AMBRA1/PSMC2/NDUFA9/COX4I2/NDUFA6/BID/CTNNB1/NDUFB2/PSMA2/PSMC5/CSNK2B/PSMB3/NDUFA12/TUBB4B/FADD/PSMA6/NDUFS2/APOE/CYBB/MAP2K2/PSMD2/PSMC4/NDUFA1/AKT3/SLC25A4/PPID/AKT1/NDUFS3	11.5814817920332
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	34/1123	46/9376	6.17104804676914	PSMB1/PSMB4/PSMB2/PSMA1/PSMB6/PSMA7/PSMA4/PSMA5/POMP/SEM1/PSMA3/PSMD11/PSMB7/PSMD7/ADRM1/PSMD4/PSMC1/PSMB5/PSMD13/PSMD6/PSMD14/PSMC3/PSMD3/PSME1/PSMD8/PSME2/PSMC2/PSMA2/PSMC5/PSMB3/PSMA6/PSMB10/PSMD2/PSMC4	12.9683959169479
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	83/1123	235/9376	2.9488187037002	ATP5MC3/GNAS/RPS6/ATP5MG/ATP5F1B/COX4I1/NDUFA11/ATP5F1C/ATP5PO/ATP5F1A/UQCRH/COX5A/ATP5MC1/UQCR10/ATP5MC2/ATP5PB/CYC1/COX5B/COX7B/SDHD/UQCRFS1/COX6C/COX8A/NDUFS8/NDUFB8/UQCRC2/ATP5PF/COA4/COX7C/NDUFA10/ATP5MF/NDUFA4/UQCRQ/COX20/NDUFB9/CPT2/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/NDUFB5/NDUFB10/COX14/NDUFS6/UQCRB/NDUFS7/NDUFS5/COX6B1/PPARG/NDUFV1/NDUFB4/NDUFA8/NDUFAF4/UQCR11/NDUFA2/SDHB/COA3/NDUFB6/NDUFB3/COA6/COX6A1/COA7/NDUFA9/COX4I2/NDUFA6/SLC25A29/NDUFB2/NDUFA12/NDUFS2/MAPK13/RHEB/COX10/NDUFA1/SMARCE1/SMARCB1/ADCY2/FGFR1/NDUFS3	11.1603575756871
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	130/1123	480/9376	2.26120510537251	SLC25A5/SLC25A6/ATP5MC3/UBA52/RPS27A/UBB/PPIF/ATP5F1B/GPX3/COX4I1/PSMB1/NDUFA11/ATP5F1C/ATP5PO/ATP5F1A/PSMB4/PSMB2/UQCRH/COX5A/PARK7/PSMA1/PSMB6/ATP5MC1/UQCR10/ATP5MC2/ATP5PB/CYC1/PSMA7/PSMA4/COX5B/COX7B/TUBA1C/PSMA5/SDHD/UQCRFS1/TUBA1B/COX6C/SEM1/COX8A/PSMA3/NDUFS8/NDUFB8/SOD1/UQCRC2/ATP5PF/PSMD11/COX7C/PSMB7/PSMD7/ADRM1/NDUFA10/NDUFA4/PSMD4/UQCRQ/PSMC1/NDUFB9/VDAC1/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/PSMB5/NDUFB11/ATP5F1D/ATP5PD/NDUFV2/SDHC/CYCS/NDUFB5/UBE2L3/NDUFB10/PSMD13/CAT/TOMM40/HSD17B10/NDUFS6/UQCRB/NDUFS7/NDUFS5/PSMD6/VCP/PSMD14/COX6B1/CALM3/NDUFV1/NDUFB4/NDUFA8/PSMC3/PSMD3/UQCR11/NDUFA2/TUBB/SDHB/NDUFB6/NDUFB3/VDAC3/BAX/PSMD8/COX6A1/RAB8A/AMBRA1/PSMC2/NDUFA9/COX4I2/NDUFA6/BID/CTNNB1/NDUFB2/PSMA2/PSMC5/CSNK2B/PSMB3/NDUFA12/TUBB4B/FADD/PSMA6/NDUFS2/MAPK13/BAK1/TRAP1/CYBB/MAP2K2/PSMD2/PSMC4/NDUFA1/SLC25A4/PPID/RYR1/DAXX/NDUFS3	10.463537749317
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	61/1123	157/9376	3.24390423739869	COX4I1/NDUFA11/UQCRH/COX5A/UQCR10/CYC1/COX5B/COX7B/SDHD/UQCRFS1/COX6C/COX8A/NDUFS8/NDUFB8/UQCRC2/COX7C/NDUFA10/NDUFA4/UQCRQ/NDUFB9/CEBPA/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/NDUFB11/NDUFV2/SDHC/CYCS/NDUFB5/NDUFB10/NDUFS6/UQCRB/NDUFS7/NDUFS5/COX6B1/PPARG/NDUFV1/NDUFB4/NDUFA8/UQCR11/NDUFA2/SDHB/NDUFB6/NDUFB3/BAX/LEP/COX6A1/NDUFA9/COX4I2/NDUFA6/BID/NDUFB2/NDUFA12/NDUFS2/MAPK13/NDUFA1/CXCL8/AKT3/AKT1/NDUFS3	10.4587993490296
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	56/1123	158/9376	2.95916228005906	CCNE1/ANAPC11/E2F4/MCM5/SKP2/CCND3/CCNB2/MCM7/CDC20/CDK1/MAD2L1/CDT1/ORC6/CCNA2/CCNB1/PTTG1/CDC6/MCM3/AURKB/PCNA/CDCA5/MCM2/CDC45/MYC/E2F5/SGO1/TTK/HDAC1/PKMYT1/YWHAB/YWHAE/RB1/NDC80/CHEK1/TRIP13/PLK1/CDC25A/MCM6/TFDP1/CDK4/BUB1/E2F1/ANAPC15/E2F3/CHEK2/CCNE2/ESCO2/CDKN1C/ORC1/CDKN1B/BUB1B/FBXO5/TP53/CDC25C/ORC3/MCM4	9.16115425950059
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	22/1123	36/9376	5.10220639160978	SSBP1/MCM5/RNASEH2C/MCM7/POLE4/FEN1/MCM3/PCNA/RFC4/MCM2/RPA3/RFC2/RPA2/POLE2/POLA2/MCM6/RNASEH2A/RFC5/LIG1/POLD1/RNASEH2B/MCM4	9.09630288745455
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	45/1123	144/9376	2.60908281389136	SLC25A5/SLC25A6/PPIF/PSMB1/PSMB4/PSMB2/PSMA1/PSMB6/PSMA7/PSMA4/PSMA5/SEM1/PSMA3/PSMD11/PSMB7/PSMD7/ADRM1/PSMD4/PSMC1/VDAC1/PSMB5/CYCS/PSMD13/PSMD6/PSMD14/RBPJ/NOP56/PSMC3/PSMD3/VDAC3/PSMD8/AMBRA1/PSMC2/PSMA2/PSMC5/PSMB3/PSMA6/PSMD2/PSMC4/AKT3/SLC25A4/RYR1/AFG3L2/AKT1/TWNK	7.1776344806723
Genetic Information Processing	Transcription	hsa03040	Spliceosome	59/1123	243/9376	2.02713923976415	HNRNPA1/SNRPD2/SNRPG/SNRPD1/HNRNPA3/SRSF3/MAGOH/SNRPE/SNRPF/HSPA8/SRSF9/SNRPD3/SNRPB/RBM8A/LSM3/HNRNPC/LSM7/SNU13/HNRNPA1L3/LSM6/SF3B5/SNRNP40/PPIL1/ALYREF/U2AF1/THOC3/SRSF7/SNRPC/CTNNBL1/THOC6/EIF4A3/SRSF2/PRPF19/HNRNPM/SNRPA/CWC15/HNRNPK/LSM4/PPIH/RBM17/RBMX/PHF5A/SNRPB2/SNRPA1/BUD31/U2AF2/DDX5/LSM5/CDC40/LSM8/PRPF6/USP39/DDX39B/SF3B6/HSPA6/SRSF6/CDC5L/PRPF31/PUF60	5.98405150168847
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	34/1123	116/9376	2.44713974268431	ECHS1/ACSS1/TKT/IDH2/MDH2/ADH5/GCSH/SDHD/RPIA/IDH1/ACADS/PHGDH/SDHC/FH/CAT/SHMT2/GAPDH/PGP/MDH1/PGAM1/SUCLG1/SDHB/IDH3B/PCCB/PSAT1/PDHB/FBP1/PGD/PDHA1/SHMT1/ENO1/ESD/GOT1/MCEE	5.78500269661739
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	22/1123	59/9376	3.1132106796263	MGST3/GSTP1/GPX3/IDH2/PRDX6/GSTO1/GSTA4/SMS/GSTA3/SRM/GSTT1/IDH1/RRM2/GSR/GSS/GGCT/HPGDS/GCLM/GPX4/PGD/RRM1/LAP3	6.00620773145507
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	48/1123	205/9376	1.95490302543275	CCNE1/SEM1/PSMD11/SKP2/CCND3/PSMD7/ADRM1/PSMD4/PSMC1/CCNA2/CYCS/PSMD13/PSMD6/PSMD14/RBPJ/PSMC3/PSMD3/MYC/NFKBIA/HLA-G/HDAC1/BAX/PSMD8/RB1/HLA-DRA/PSMC2/BID/PSMC5/HLA-E/CDK4/E2F1/FADD/E2F3/MAPK13/BAK1/PLCG2/CCNE2/PSMD2/CDKN1B/PSMC4/HLA-DRB1/TAP1/AKT3/ICAM1/IRF7/TP53/AKT1/OAS3	5.09914599921819
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	24/1123	75/9376	2.67170080142476	CCNE1/CCND3/CCNB2/SIAH1/SIVA1/CDK1/CCNB1/CYCS/PMAIP1/RRM2/SHISA5/ZNF385A/BAX/CCNG1/STEAP3/CHEK1/BID/GTSE1/CDK4/AIFM2/CHEK2/CCNE2/IGF1/TP53	5.36159436373664
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	38/1123	157/9376	2.02079280362541	CCNE1/SLC25A5/SLC25A6/E2F4/CCND3/CCNB2/CDK1/VDAC1/CCNA2/CCNB1/PPP1CA/CALM3/PPP1CC/MYC/MYBL2/E2F5/VDAC3/HLA-G/RB1/CHEK1/RAD1/CDC25A/HLA-E/CDK4/E2F1/E2F3/MAPK13/CHEK2/RHEB/MAP2K2/CCNE2/CXCL8/AKT3/SLC25A4/PPID/LIN9/TP53/AKT1	4.75789783365638
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	16/1123	44/9376	3.03602363798268	PARP1/HMGB1/APEX1/POLE4/FEN1/PCNA/RFC4/MUTYH/RFC2/POLE2/UNG/NEIL3/RFC5/LIG1/POLD1/LIG3	4.99334280865026
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	20/1123	63/9376	2.65049682681027	POLR2E/POLE4/RAD23A/POLR2F/POLR2G/POLR2H/POLR2J/PCNA/RFC4/RPA3/RFC2/GTF2H5/RPA2/POLE2/DDB1/RAD23B/RFC5/LIG1/POLR2L/POLD1	4.84852635608722
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	24/1123	85/9376	2.35738306008067	PNP/NME1/TK1/TYMS/APRT/GMPR/RRM2/DCTPP1/IMPDH2/NME4/AK2/DTYMK/ADSL/NTPCR/DUT/NT5C3B/UCKL1/NME6/RRM1/ITPA/GMPR2/CMPK2/DGUOK/TYMP	4.63714046629731
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/1123	30/9376	3.33962600178094	IDH2/MDH2/SDHD/IDH1/SDHC/FH/MDH1/SUCLG1/SDHB/IDH3B/PDHB/PDHA1	4.73438718317387
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	17/1123	54/9376	2.62840935325352	LDHB/DNMT1/MDH2/SMS/SRM/CDO1/PHGDH/CISD1/MDH1/LDHA/AHCY/GSS/GCLM/PSAT1/TST/GOT1/BCAT2	4.42665333749962
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	34/1123	149/9376	1.90515577282806	NDUFA11/NDUFS8/GNG5/NDUFB8/NDUFA10/NDUFA4/NDUFB9/NDUFAB1/NDUFA13/NDUFC2/NDUFA7/NDUFB11/NDUFV2/NDUFB5/NDUFB10/NDUFS6/NDUFS7/NDUFS5/NDUFV1/NDUFB4/NDUFA8/NDUFA2/NDUFB6/NDUFB3/NDUFA9/NDUFA6/GNG12/NDUFB2/NDUFA12/NDUFS2/MAPK13/NDUFA1/ADCY2/NDUFS3	4.10823987183816
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	16/1123	50/9376	2.67170080142476	ALDH7A1/CKMT1B/SMS/CKMT1A/SRM/SAT1/CNDP2/ARG2/ALDH9A1/PYCR2/AOC1/ALDH18A1/GATM/GAMT/GOT1/LAP3	4.37185189594238
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	46/1123	224/9376	1.7145401348429	CCNE1/SLC25A5/SLC25A6/MSX2/RAN/RANBP1/ANAPC11/CCND3/CCNB2/CDC20/NFYB/MAD2L1/VDAC1/CCNA2/PTTG1/MYC/VDAC3/NFKBIA/HLA-G/BAX/RB1/HLA-DRA/CHEK1/HLA-E/CDK4/ITGB2/E2F1/ANAPC15/E2F3/FDPS/CHEK2/SPI1/MAP2K2/CCNE2/CD4/HLA-DRB1/ADCY2/AKT3/BUB1B/SLC25A4/IL2RA/ICAM1/TP53/AKT1/GPS2/CANX	3.99265904337339
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/1123	23/9376	3.63002826280537	SSBP1/PCNA/RFC4/RPA3/RFC2/RPA2/EXO1/RFC5/LIG1/POLD1	4.65820352980864
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	17/1123	56/9376	2.53453759063732	EEF1A1/HSPD1/HSPA8/CYCS/VCP/EEF1G/CR1/CD14/NFKBIA/PYCARD/ITGB2/CASP1/HSPA6/CXCL8/TLR4/ITGAM/CXCL1	4.24847613127227
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	11/1123	31/9376	2.96257145319277	ACSS1/MDH2/GCSH/CAT/SHMT2/PGP/MDH1/PCCB/SHMT1/GLUL/MCEE	4.03725578314157
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	33/1123	155/9376	1.77754287191566	TUBA1C/ATP6V1C2/TUBA1B/COLEC12/OLR1/MRC1/RAB5C/TUBB/CD14/SEC61B/HLA-G/ATP6V1B2/HLA-DRA/FCGR2A/ATP6V0A4/HLA-E/ITGB2/TUBB4B/ATP6V0C/ATP6V1B1/CYBB/FCGR3A/CYBA/HLA-DRB1/TAP1/FCGR1A/ATP6V0D1/TLR4/ITGAM/MSR1/ATP6V0E2/CANX/FCGR2B	3.60056600048489
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	19/1123	75/9376	2.1150964677946	ASS1/TKT/IDH2/RPIA/IDH1/PHGDH/ARG2/SHMT2/GAPDH/PGAM1/IDH3B/PSAT1/PYCR2/ALDH18A1/SHMT1/ENO1/GLUL/GOT1/BCAT2	3.57641447061259
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	12/1123	42/9376	2.38544714412925	SLC40A1/FTH1/SAT1/GSS/LPCAT3/VDAC3/GCLM/STEAP3/GPX4/HMOX1/CYBB/TP53	3.31932901690507
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/1123	82/9376	1.93453945225116	HSP90AB1/HSPA8/NFYB/HSP90AA1/LGMN/IFI30/HLA-G/PSME1/PSME2/HLA-DRA/HLA-E/RFXANK/HSPA4/CTSB/CD4/HSPA6/HLA-DRB1/TAP1/CANX	3.13525468908152
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/1123	59/9376	2.12264364519975	NME1/TK1/TYMS/RRM2/DCTPP1/NME4/DTYMK/DUT/UMPS/NT5C3B/UCKL1/NME6/RRM1/CMPK2/TYMP	3.19079919786325
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	36/1123	195/9376	1.54136584697582	SLC25A5/SLC25A6/PPIF/HMGB1/VDAC1/H4C3/CASP4/H2AZ1/H3-3A/H2AX/CR1/VDAC3/HDAC1/FCGR2A/H3C2/ITGB2/H2AC16/H3C8/MAPK13/PLCG2/CYBB/MAP2K2/FCGR3A/CYBA/CASP1/TLR7/FCGR1A/AKT3/SLC25A4/HDAC3/TLR4/ITGAM/H3C7/AKT1/H2BC9/H2AC12	2.81794660543888
Human Diseases	Infectious disease: viral	hsa05162	Measles	27/1123	136/9376	1.65753496411922	CCNE1/RACK1/HSPA8/EIF3H/CCND3/CYCS/NFKBIA/BAX/BID/CSNK2B/CDK4/FADD/BAK1/CD28/CCNE2/CDKN1B/HSPA6/TLR7/MX2/AKT3/TLR4/IL2RA/IRF7/TP53/AKT1/OAS3/FCGR2B	2.84919329425566
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	19/1123	87/9376	1.82335902396086	COX4I1/UQCRH/COX5A/UQCR10/CYC1/COX5B/COX7B/UQCRFS1/COX6C/COX8A/UQCRC2/COX7C/UQCRQ/UQCRB/COX6B1/UQCR11/TNNC1/COX6A1/COX4I2	2.84599405367158
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	17/1123	75/9376	1.89245473434253	MGST3/GSTP1/GSTO1/GSTA4/GSTA3/GSTT1/BIRC5/CYCS/PMAIP1/TOP2A/BAX/BID/FADD/BAK1/AKT3/TP53/AKT1	2.86234251336296
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/1123	30/9376	2.50471950133571	GGH/TYMS/ATIC/SHMT2/DHFR/FOLR2/SLC19A1/SHMT1/ABCG2	3.0448989351173
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/1123	41/9376	2.23999304997502	ALDH7A1/GCSH/PHGDH/SHMT2/PGAM1/ALAS1/PSAT1/GATM/SHMT1/CHDH/GAMT	2.93510479551388
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	11/1123	41/9376	2.23999304997502	SSBP1/SEM1/RAD51/BABAM1/RPA3/RPA2/RAD51C/EME1/TOPBP1/BLM/POLD1	2.93510479551388
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	18/1123	82/9376	1.8327215863432	MGST3/GSTP1/GSTO1/GSTA4/NME1/GSTA3/TK1/GSTT1/RRM2/IMPDH2/NME4/DUT/UMPS/UCKL1/NME6/RRM1/ITPA/TYMP	2.79366938655499
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/1123	47/9376	2.13167617134954	LDHB/ALDH7A1/ACSS1/MDH2/ADH5/FH/MDH1/LDHA/AKR1A1/PDHB/ALDH9A1/PDHA1	2.86895111125333
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	36/1123	201/9376	1.49535492617057	MLLT1/ETV5/HPGD/CEBPA/NUPR1/CCNA2/FLT1/CEBPB/PPARG/H3-3A/ETV7/MYC/CD14/HDAC1/BAX/MYCN/DDX5/H3C2/H3C8/MAF/BAK1/ID2/SPI1/CDKN1B/MEF2C/BCL6/IGF1/CD86/FCGR1A/CXCL8/LYL1/ITGAM/H3C7/FLI1/TP53/HHEX	2.61867180552165
NA	NA	hsa04981	Folate transport and metabolism	9/1123	31/9376	2.42392209806681	TYMS/MTHFS/SHMT2/DHFR/FOLR2/SLC19A1/SHMT1/ABCG2/SLCO2B1	2.92918645882222
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	12/1123	48/9376	2.08726625111309	ECHS1/ALDH7A1/ACADS/HADHB/HSD17B10/PCCB/IVD/ALDH9A1/HADH/HIBADH/BCAT2/MCEE	2.78568401076065
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	11/1123	43/9376	2.13580732672037	ECHS1/ALDH7A1/ADH5/ECI1/CPT2/ACADS/HADHB/ECI2/ACADVL/ALDH9A1/HADH	2.75358098848104
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	31/1123	173/9376	1.49607523201169	SLC25A5/SLC25A6/CCND3/VDAC1/CYCS/KPNA2/CPSF4/NFKBIA/BAX/HLA-DRA/PYCARD/NXT1/BID/CDK4/FADD/BAK1/FDPS/MAP2K2/TLR3/CASP1/HLA-DRB1/TLR7/MX2/CXCL8/AKT3/SLC25A4/TLR4/ICAM1/IRF7/AKT1/OAS3	2.42926827475314
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	10/1123	39/9376	2.14078589857753	ALDH7A1/GCSH/TYMS/ATIC/MTHFS/SHMT2/DHFR/AHCY/SHMT1/CHDH	2.63331226574296
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	32/1123	181/9376	1.47607779084241	HSPD1/NFYB/CYCS/CEBPB/CALM3/MRC1/RAB5C/CR1/CD14/BAX/HLA-DRA/FCGR2A/ATP6V0A4/BID/ITGB2/HSPA9/RFXANK/FADD/IL10RB/MAPK13/ATP6V0C/FCGR3A/HLA-DRB1/FCGR1A/AKT3/ATP6V0D1/TLR4/ITGAM/FCER1G/AKT1/IL10RA/FCGR2B	2.38567311526057
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	28/1123	154/9376	1.51801181899134	QPRT/NME1/GGH/UGP2/SHMT2/ALAS1/DHFR/HMBS/NME4/GSS/AK2/ADSL/AKR1A1/MOCS2/GCLM/PSAT1/UMPS/SHMT1/COQ2/NADK/NAPRT/RDH13/COX10/NME6/FECH/UROS/BCAT2/CMPK2	2.39087606319787
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1123	51/9376	1.96448588340056	GNAS/ATP6V1C2/SEC61B/ATP6V1B2/ATP6V0A4/ATP6V0C/PLCG2/ATP6V1B1/ATP6V0D1/TJP2/KDELR2/ATP6V0E2	2.54757006499906
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	9/1123	34/9376	2.21004661882562	POLR2E/POLR2F/POLR2G/POLR2H/POLR2J/POLR1D/POLR3K/POLR2L/POLR1G	2.60730131267519
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	35/1123	205/9376	1.42545012271138	CCNE1/RANBP1/SKP2/CCND3/CDC20/PSMC1/CDK1/CCNA2/H4C3/PMAIP1/RBPJ/GTF2A2/HNRNPK/VDAC3/NFKBIA/HLA-G/HDAC1/BAX/YWHAB/YWHAE/RB1/CHEK1/DDB1/HLA-E/CDK4/BAK1/CCNE2/CDKN1B/ATP6V0D1/HDAC3/SND1/IRF7/ACTN4/TP53/H2BC9	2.27188754597092
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	16/1123	78/9376	1.71262871886202	HSPD1/LSM3/BTG3/LSM7/LSM6/EXOSC3/EXOSC4/LSM4/MPHOSPH6/EXOSC8/LSM5/HSPA9/LSM8/ENO1/DCPS/TOB2	2.33123172469804
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	25/1123	138/9376	1.51251177616891	CCNE1/ANAPC11/CCNB2/CDC20/CDK1/MAD2L1/CCNB1/PTTG1/PPP1CA/CALM3/PPP1CC/AURKA/SGO1/PKMYT1/YWHAB/YWHAE/PLK1/BUB1/ANAPC15/MAPK13/CCNE2/IGF1/ADCY2/FBXO5/CDC25C	2.23729888814184
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	31/1123	180/9376	1.43789452854457	SRSF3/SRSF9/CYCS/ALYREF/SRSF7/PPP1CA/SRSF2/PPP1CC/ZC3HAV1/NFKBIA/HLA-G/BAX/HLA-DRA/BID/HLA-E/FADD/BAK1/EIF2B2/RHEB/TLR3/HLA-DRB1/TAP1/AKT3/SRSF6/IRF7/TP53/AKT1/EIF2B1/TNFRSF14/OAS3/DAXX	2.18814392245306
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	12/1123	54/9376	1.85534777876719	CENPX/UBE2T/RAD51/RMI2/RPA3/RPA2/RAD51C/CENPS/RMI1/FANCI/EME1/BLM	2.32516970750486
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/1123	106/9376	1.57529528385894	CCNE1/GSTP1/HSP90AB1/ETV5/HSP90AA1/FOLR2/SLC19A1/NFKBIA/RB1/CTNNB1/E2F1/E2F3/MAP2K2/CCNE2/CDKN1B/IGF1/AKT3/TP53/AKT1/FGFR1	2.19721964399633
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/1123	67/9376	1.744580747199	LDHB/ALDH7A1/ACSS1/ADH5/GAPDH/PGAM1/LDHA/AKR1A1/PDHB/FBP1/ALDH9A1/PDHA1/ENO1/PGM1	2.25614642602613
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/1123	93/9376	1.61594806537788	CCNE1/CKS2/CKS1B/SKP2/CYCS/MYC/NFKBIA/BAX/RB1/CDK4/E2F1/E2F3/BAK1/CCNE2/CDKN1B/AKT3/TP53/AKT1	2.20196792395065
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	33/1123	196/9376	1.40570992421902	UBA52/RPS27A/UBB/GNG5/CYCS/CALM3/MYC/NFKBIA/HLA-G/BAX/RB1/GNG12/BID/CTNNB1/HLA-E/CDK4/E2F1/FADD/E2F3/MAPK13/BAK1/PLCG2/PREX1/MAP2K2/TLR3/CD86/CXCL8/AKT3/ICAM1/IRF7/TP53/AKT1/CXCL1	2.11734642573315
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	40/1123	248/9376	1.3466233878149	RPS3/PFN1/ARPC2/HSP90AB1/ARPC1B/ARPC5/TUBA1C/TUBA1B/TXN2/CASP4/ARPC3/CYCS/GAPDH/HSP90AA1/RAB5C/DYNLRB1/TUBB/MYC/CD14/NFKBIA/BAX/PYCARD/LY96/CTNNB1/TUBB4B/FADD/MAPK13/BAK1/MYL12A/MAP2K2/DYNLL2/CYTH4/CASP1/CXCL8/AKT3/SNX18/TLR4/ARPC1A/RHOG/AKT1	2.04063570447561
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	20/1123	108/9376	1.54612314897266	EEF1A1/RAN/MAGOH/UBE2I/RBM8A/KPNA2/ALYREF/THOC3/THOC6/EIF4A3/NUP37/SAP18/NXT1/SUMO1/DDX39B/PYM1/PNN/NUP85/SUMO2/XPOT	2.10561538257808
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1123	32/9376	2.08726625111309	LDHB/ECHS1/ACSS1/ACADS/LDHA/SUCLG1/PCCB/MCEE	2.27255328884273
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	18/1123	95/9376	1.58192810610676	ATP6V1C2/FLT1/ATP6V1B2/HLA-DRA/CCL3/ATP6V0A4/ITGB2/CD28/ATP6V0C/ATP6V1B1/HLA-DRB1/CD86/CXCL8/ATP6V0D1/TLR4/ICAM1/ATP6V0E2/CXCL1	2.10282602572681
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	25/1123	143/9376	1.45962674903013	SNRPD1/SNRPD3/SNRPB/C1QA/H4C3/H2AZ1/C1QB/C1QC/H3-3A/H2AX/HLA-DRA/FCGR2A/H3C2/H2AC16/H3C8/CD28/FCGR3A/HLA-DRB1/CD86/FCGR1A/C2/H3C7/ACTN4/H2BC9/H2AC12	2.04301469407292
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	16/1123	83/9376	1.6094583141113	IDH2/PRDX1/SLC27A2/SOD1/IDH1/HSD17B4/ECI2/CAT/PRDX5/EPHX2/PXMP2/FAR2/ECH1/PMVK/ACOT8/MPV17L2	2.05719129232419
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	20/1123	110/9376	1.51801181899134	LDHB/RPS6/FLT1/GAPDH/LDHA/ELOC/PDHB/HMOX1/PDHA1/ENO1/PLCG2/CYBB/MAP2K2/CDKN1B/EIF4E/IGF1/AKT3/EGLN2/TLR4/AKT1	2.01585577506312
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	20/1123	110/9376	1.51801181899134	HSP90AB1/ANAPC11/CCNB2/CDK1/MAD2L1/CCNA2/CCNB1/HSP90AA1/AURKA/PKMYT1/PLK1/CDC25A/BUB1/ANAPC15/MAPK13/IGF1/ADCY2/AKT3/AKT1/CDC25C	2.01585577506312
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	15/1123	77/9376	1.62644123463358	MYC/NFKBIA/HDAC1/BAX/RB1/CDK4/E2F1/E2F3/BAK1/MAP2K2/CDKN1B/CBL/AKT3/TP53/AKT1	2.03599716686448
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	40/1123	253/9376	1.32001027738377	UBA52/RPS27A/PFN1/UBB/FOXO4/ARPC2/ARPC1B/ARPC5/UBE2N/VDAC1/HCLS1/CASP4/ARPC3/CYCS/U2AF1/CBX3/H3-3A/CD14/NFKBIA/BAX/PYCARD/H3C2/SEPTIN3/RRAGA/H3C8/MAPK13/PLCG2/MYL12A/CYTH4/CASP1/CXCL8/AKT3/PPID/TLR4/ARPC1A/H3C7/SHARPIN/ACTN4/TP53/AKT1	1.90337755266482
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	15/1123	78/9376	1.60558942393315	CFL1/C1QA/C1QB/C1QC/CALM3/CD14/PYCARD/LY96/ITGB2/MAPK13/CASP1/CXCL8/C2/TLR4/ITGAM	1.98107266778271
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	15/1123	78/9376	1.60558942393315	EEF1A1/CR1/NFKBIA/HLA-DRA/FCGR2A/ITGB2/MAPK13/CYBB/MARCKSL1/FCGR3A/CYBA/HLA-DRB1/FCGR1A/TLR4/ITGAM	1.98107266778271
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1123	28/9376	2.08726625111309	ATP6V1C2/ATP6V1B2/ATP6V0A4/ATP6V0C/ATP6V1B1/ATP6V0D1/ATP6V0E2	2.12532409198512
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	28/1123	168/9376	1.39151083407539	SLC25A5/SLC25A6/HSP90AB1/PARP1/HMGB1/PPIA/FTH1/VDAC1/H2AZ1/HSP90AA1/H2AX/VDAC3/BAX/PYCARD/BID/FADD/H2AC16/GLUL/CYBB/TLR3/CASP1/SLC25A4/PPID/TLR4/CHMP1A/SHARPIN/CHMP4A/H2AC12	1.88879734626535
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/1123	41/9376	1.8327215863432	MYC/RB1/CDK4/E2F1/E2F3/MAP2K2/CXCL8/TP53/TYMP	1.9710796939169
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	24/1123	142/9376	1.4111095782173	UBA52/RPS27A/UBB/UBE2I/ANAPC11/SKP2/SIAH1/UBE2N/UBE2C/CDC20/UBE2L3/UBE2S/PRPF19/ELOC/UBE2A/UBE2F/DDB1/ANAPC15/CDC34/RHOBTB1/TRIM37/CBL/UBE2Z/SAE1	1.82085945729358
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1123	37/9376	1.80520324420592	PPARG/MYC/BAX/CTNNB1/BAK1/MAP2K2/TP53/TFG	1.81019676371346
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/1123	250/9376	1.26905788067676	ARPC2/CLTA/ARPC1B/ARPC5/SNX3/AP2M1/HSPA8/ARPC3/RAB31/RAB5C/FOLR2/SNX4/ARRB1/SPG21/HLA-G/RAB8A/SNX5/CAPZB/HLA-E/SNF8/PRKCZ/VPS28/ARRB2/ARF4/CYTH4/PLD2/CBL/PARD6A/VPS29/HSPA6/GRK3/IL2RA/ARPC1A/LDLRAP1/CHMP1A/SNX6/CHMP4A/PSD3	1.59054178496985
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	26/1123	163/9376	1.3317527000967	CCNE1/BIRC5/CCNA2/CYCS/PCNA/MYC/VDAC3/NFKBIA/BAX/YWHAB/RB1/BID/DDB1/E2F1/FADD/E2F3/MAPK13/MAP2K2/CCNE2/TLR3/CXCL8/AKT3/TLR4/IRF7/TP53/AKT1	1.5760766199733
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/1123	71/9376	1.52870204306874	ATP6V1C2/JAM3/NFKBIA/ATP6V1B2/ATP6V0A4/MAPK13/ATP6V0C/PLCG2/ATP6V1B1/CXCL8/ATP6V0D1/ATP6V0E2/CXCL1	1.6494971444956
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/1123	71/9376	1.52870204306874	LDHB/IDH2/IDH1/PGAM1/LDHA/MYC/PDHB/PDHA1/MAP2K2/AKT3/TP53/AKT1/FGFR1	1.6494971444956
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	25/1123	156/9376	1.33799118661096	CYCS/MYC/NFKBIA/BAX/EIF3E/YWHAB/YWHAE/RB1/BID/CTNNB1/CLDN19/CDK4/E2F1/FADD/E2F3/BAK1/MAP2K2/CLDN7/TLR3/MX2/AKT3/IRF7/TP53/AKT1/OAS3	1.57026086936258
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1123	32/9376	1.82635796972395	BIRC5/CYCS/PMAIP1/BAX/BID/FADD/BAK1	1.72721494844066
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/1123	142/9376	1.35231334579158	MGST3/GSTP1/ASS1/HSP90AB1/GSTO1/GSTA4/GSTA3/TXN2/GSTT1/CALM3/HSP90AA1/CTNNB1/SUMO1/HMOX1/MAPK13/PRKCZ/CYBA/MEF2C/AKT3/ICAM1/TP53/AKT1/SUMO2	1.56044305850801
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	21/1123	128/9376	1.36976847729297	PNP/NME1/ATIC/APRT/GMPR/RRM2/IMPDH2/NME4/AK2/ADSL/NTPCR/PAICS/NUDT5/PGM1/PPAT/ADCY2/NME6/RRM1/ITPA/GMPR2/DGUOK	1.5537478937505
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/1123	73/9376	1.48681979531343	MLLT1/RAN/PPIA/PSIP1/NELFCD/FEZ1/NELFE/SAMHD1/CD4/SMARCB1/MX2/ELL/CHMP4A	1.54023767687061
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1123	33/9376	1.77101378882323	IDH2/IDH1/IDH3B/PDHB/PDHA1/GOT1/BCAT2	1.63661125816969
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1123	46/9376	1.63351271826242	FTH1/FXN/ALAS1/HMBS/HMOX1/COX10/FECH/UROS/HMOX2	1.58877729902008
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1123	28/9376	1.78908535809693	AKR1B1/GGH/PCBD1/DHFR/MOCS2/CBR1	1.54245762753992
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1123	22/9376	1.89751477373917	ALDH7A1/CNDP2/HNMT/ALDH9A1/AOC1	1.55461859304943
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/1123	83/9376	1.40827602484739	POLR2E/GSDME/POLR2F/POLR2H/NFKBIA/POLR1D/PYCARD/POLR3K/FADD/CCL4/CASP1/SAMHD1/POLR2L/IRF7	1.37811210994062
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/1123	76/9376	1.42812954023527	CALM3/BAX/RB1/CDK4/E2F1/E2F3/BAK1/PLCG2/MAP2K2/IGF1/AKT3/TP53/AKT1	1.38232483322007
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	32/1123	216/9376	1.23689851917813	HSPD1/HSP90AB1/HSPA8/CYCS/VAV3/CALM3/PPARG/OLR1/HSP90AA1/CYP2J2/CD14/NFKBIA/BAX/PYCARD/CCL3/LY96/BID/MAPK13/CYBB/HSPA4/CYBA/CASP1/HSPA6/CASP6/CXCL8/AKT3/TLR4/ICAM1/IRF7/TP53/AKT1/CXCL1	1.29930490671912
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/1123	105/9376	1.35175338167324	UBA52/RPS27A/UBB/TFEB/PHB2/SIAH1/TOMM40/VCP/RAB5C/AMBRA1/MTX1/GABARAP/CSNK2B/E2F1/MTX2/TOMM70/TP53	1.33702409558843
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	16/1123	98/9376	1.36311265378814	ARPC2/CFL1/ARPC1B/ARPC5/ARPC3/VAV3/FCGR2A/PLCG2/MARCKSL1/FCGR3A/PLD2/FCGR1A/AKT3/ARPC1A/AKT1/FCGR2B	1.33289773833034
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/1123	99/9376	1.34934383910341	C1QA/C1QB/C1QC/HLA-DRA/FCGR2A/ITGB2/C3AR1/FCGR3A/PTAFR/HLA-DRB1/FCGR1A/CFB/C2/ITGAM/ICAM1/FCGR2B	1.2889512777825
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	21/1123	137/9376	1.27978368681387	PARP1/TUBA1C/TUBA1B/BIRC5/CYCS/LMNB1/PMAIP1/DFFA/LMNB2/NFKBIA/BAX/BID/FADD/BAK1/MAP2K2/CTSB/CASP6/AKT3/TP53/AKT1/DAXX	1.21685766628915
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	31/1123	214/9376	1.20944399597207	CFL1/GNG5/CCNB2/CDK1/CCNB1/CYCS/CALM3/AP1S3/AP1S1/NFKBIA/HLA-G/BAX/ELOC/CHEK1/GNG12/BID/DDB1/HLA-E/FADD/MAPK13/BAK1/PLCG2/MAP2K2/SAMHD1/CD4/TAP1/AKT3/TLR4/PAK6/AKT1/CDC25C	1.14327116979946
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	17/1123	109/9376	1.30214775298798	SPP1/CD14/NFKBIA/CCL3/LY96/FADD/MAPK13/CCL4/MAP2K2/TLR3/TLR7/CD86/CXCL8/AKT3/TLR4/IRF7/AKT1	1.17039546429214
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	29/1123	200/9376	1.21061442564559	RPS3/ARPC2/ARPC1B/ARPC5/TUBA1C/TUBA1B/NCL/HCLS1/CASP4/ARPC3/CYCS/GAPDH/TUBB/NFKBIA/BAX/PYCARD/FCGR2A/CLDN19/TUBB4B/FADD/MAPK13/BAK1/CLDN7/CYTH4/MYO1F/CASP1/CXCL8/TLR4/ARPC1A	1.11057016774159
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/1123	73/9376	1.37244904182779	BAX/RB1/CDK4/E2F1/E2F3/BAK1/MAP2K2/IGF1/AKT3/TP53/AKT1/FGFR1	1.17838274544314
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/1123	31/9376	1.61594806537788	TKT/RPIA/FBP1/PGD/PGM1/RBKS	1.2670824723432
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1123	18/9376	1.85534777876719	HEXB/FUCA1/AGA/GLB1	1.33985270632741
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1123	52/9376	1.44503048153983	VDAC1/PLTP/VDAC3/APOC2/APOC1/APOE/ANGPTL4/LDLRAP1/MYLIP	1.1870250700111
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	16/1123	103/9376	1.29694213661396	MAGOH/RBM8A/ALYREF/PPP1CA/EIF4A3/PPP1CC/CPSF4/PAPOLA/SAP18/NXT1/SSU72/DDX39B/PYM1/PNN/ETF1/PAPOLG	1.11776345242439
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/1123	70/9376	1.31199592927109	CYCS/SSPN/HLA-G/HLA-DRA/BID/HLA-E/ITGB2/CD28/HLA-DRB1/CD86/ICAM1	0.966464747248556
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/1123	63/9376	1.32524841340514	HPGD/PLAAT3/PTGES3/EPHX2/CYP2J2/HPGDS/GPX4/CBR1/PTGES2/TBXAS1	0.955455035753081
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1123	28/9376	1.49090446508078	ECHS1/HADHB/ELOVL4/HADH/ACOT4	0.959591163094723
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	31/1123	227/9376	1.14018068342741	GNAS/GNG5/CYCS/CALM3/MYC/NFKBIA/HLA-G/BAX/RB1/CCL3/GNG12/BID/CTNNB1/HLA-E/CDK4/E2F1/FADD/IL10RB/E2F3/MAPK13/BAK1/CCL4/RHEB/MAP2K2/TAP1/ADCY2/CXCL8/AKT3/TP53/AKT1/IL10RA	0.788649226236942
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/1123	73/9376	1.25807828834214	BAX/RB1/CDK4/E2F1/E2F3/BAK1/PLCG2/MAP2K2/AKT3/TP53/AKT1	0.816527814015671
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/1123	44/9376	1.32826034161742	HSPD1/HLA-G/HLA-DRA/HLA-E/CD28/HLA-DRB1/CD86	0.80505765532491
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/1123	144/9376	1.15959236172949	ALDH7A1/ADH5/C1QA/C1QB/C1QC/ACADVL/CD14/NFKBIA/LY96/CTNNB1/ALDH9A1/FADD/C3AR1/MAPK13/CXCL8/AKT3/C2/TLR4/AKT1/CXCL1	0.711893526245122
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1123	37/9376	1.35390243315444	ASS1/NIT2/ADSL/GLUL/PPAT/GOT1	0.795616564856576
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1123	37/9376	1.35390243315444	COMT/ADH5/MIF/GSTZ1/FAH/GOT1	0.795616564856576
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1123	52/9376	1.28447153914652	GNAS/HSD17B1/CGA/CYP11A1/CYP2J2/ACOT4/IGF1/ADCY2	0.758767910690488
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/1123	68/9376	1.22780367712535	CEBPA/CCNA2/MYC/CD14/SPI1/MAP2K2/FCGR1A/AKT3/ITGAM/AKT1	0.695435077959768
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1123	23/9376	1.45201130512215	ASS1/ARG2/GLUL/GOT1	0.800584802380591
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1123	23/9376	1.45201130512215	FDPS/PMVK/FNTA/PDSS1	0.800584802380591
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	14/1123	99/9376	1.18067585921549	GNAS/BAX/RB1/CDK4/E2F1/E2F3/MAPK13/MAP2K2/CDKN1B/IGF1/ADCY2/AKT3/TP53/AKT1	0.666627985190585
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	23/1123	170/9376	1.12957938295532	ARPC2/ARPC1B/ARPC5/TUBA1C/TUBA1B/HCLS1/JAM3/ARPC3/PCNA/RAB8A/CLDN19/CDK4/PRKCZ/MYL12A/TJP3/CLDN7/MARVELD3/HSPA4/PARD6A/TJP2/ARPC1A/ACTN4/RAP2C	0.628918654650387
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	23/1123	170/9376	1.12957938295532	MGST3/GSTP1/GSTO1/GSTA4/GSTA3/GSTT1/TXNRD1/MYC/BAX/RB1/CTNNB1/CDK4/HMOX1/E2F1/E2F3/BAK1/PLCG2/MAP2K2/SMARCE1/SMARCB1/AKT3/TP53/AKT1	0.628918654650387
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	33/1123	250/9376	1.10207658058771	CLTA/TFEB/ATP6V1C2/AP2M1/VAMP8/SLC29A1/HEXB/LGMN/AP1S3/AP1S1/FUCA1/ATP6V1B2/LAMTOR1/ATP6V0A4/LAMTOR5/SLC29A2/RRAGA/ATP6V0C/ATP6V1B1/CTSB/SNAP29/BLOC1S4/AGA/TLR3/CD68/VPS29/TLR7/KXD1/LAPTM4B/ATP6V0D1/NAGPA/GLB1/ATP6V0E2	0.603428029252374
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1123	31/9376	1.3466233878149	ECHS1/ALDH7A1/ACADS/CNDP2/ALDH9A1	0.71304781018353
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/1123	77/9376	1.19272357206462	RAD51/BAX/RB1/CDK4/E2F1/E2F3/BAK1/PLD2/AKT3/TP53/AKT1	0.626371038523815
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/1123	62/9376	1.21196104903341	HSPA8/SOD1/CAT/HDAC1/HSPA6/IGF1/ADCY2/AKT3/AKT1	0.617665553597274
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/1123	39/9376	1.28447153914652	HLA-G/HLA-DRA/HLA-E/CD28/HLA-DRB1/CD86	0.656654674837211
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/1123	78/9376	1.17743224421764	ARPC2/CLTA/ARPC1B/ARPC5/HCLS1/ARPC3/CTNNB1/SEPTIN3/CBL/ARPC1A/RHOG	0.580436440121384
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1123	10/9376	1.66981300089047	ETHE1/TST	0.78171075991746
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/1123	79/9376	1.16252803859463	MGST3/GSTP1/ADH5/GSTO1/GSTA4/GSTA3/GSTT1/AKR7A2/HPGDS/CBR1/EPHX1	0.535106243456847
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/1123	88/9376	1.1385088642435	C1QA/F13A1/SERPINE2/C1QB/C1QC/CR1/VSIG4/ITGB2/C3AR1/CFB/C2/ITGAM	0.481534485129365
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/1123	57/9376	1.17179859711612	ECHS1/CPT2/ACADS/HSD17B4/HADHB/ACADVL/ELOVL4/HADH	0.479890307976289
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	4/1123	26/9376	1.28447153914652	RFX6/MNX1/MAFA/HHEX	0.535783438230022
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	18/1123	138/9376	1.08900847884161	ARPC2/ARPC1B/ARPC5/ARPC3/VAV3/NFKBIA/PYCARD/FCGR2A/MAPK13/MAP2K2/CASP1/CD4/CXCL8/AKT3/TLR4/ARPC1A/RHOG/AKT1	0.388554136718814
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1123	42/9376	1.19272357206462	ECHS1/ALDH7A1/CAT/ALDH9A1/HADH/AOC1	0.461737531963198
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	24/1123	187/9376	1.07153775458212	HSP90AB1/TXN2/VDAC1/CASP4/HSP90AA1/CARD16/VDAC3/NFKBIA/YWHAE/PYCARD/GABARAP/FADD/MAPK13/CYBB/CTSB/CYBA/CASP1/TRPM2/CXCL8/TLR4/IRF7/SHARPIN/CXCL1/OAS3	0.364495000432679
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1123	19/9376	1.31827342175564	GCSH/PDHB/PDHA1	0.51224585489463
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/1123	59/9376	1.1320766107732	MYC/BAX/CTNNB1/BAK1/MAP2K2/AKT3/TP53/AKT1	0.375390664271423
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	15/1123	117/9376	1.07039294928876	RBBP7/H2AZ1/RUVBL1/H2AX/HDAC1/MORF4L2/RUVBL2/MBD3/ZNHIT1/H2AC16/CDK2AP2/SMARCE1/SMARCB1/DPF2/H2AC12	0.282624393930868
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1123	36/9376	1.15959236172949	AKR1B1/DCXR/UGP2/AKR1A1/CRYL1	0.353882843092646
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1123	20/9376	1.25235975066785	NPL/UGP2/NANS	0.416734614201798
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/1123	217/9376	1.03882375631435	GNAS/MGST3/HSP90AB1/GSTO1/GSTA4/GSTA3/CCND3/PTGES3/GSTT1/BIRC5/KPNA2/CDC6/HSP90AA1/EPHX2/ARRB1/MYC/RB1/CDC25A/ADRB1/E2F1/EPHX1/MAP2K2/ARRB2/BCL6/ADCY2/AKT3/AKT1	0.213438609814599
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/1123	45/9376	1.11320866726031	HLA-G/HLA-DRA/HLA-E/CD28/HLA-DRB1/CD86	0.280796334137972
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	9/1123	70/9376	1.07345121485816	MGST3/GSTP1/GSTO1/GSTA4/GSTA3/GSTT1/HPGDS/CBR1/EPHX1	0.227528641059005
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/1123	103/9376	1.05376548599884	GNAS/SERPINB9/SERPINB6/PRDX1/ARG2/RAB5C/CD14/ITGB2/CXCL8/TLR4/ITGAM/ACTN4/CXCL1	0.202386552264456
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1123	13/9376	1.28447153914652	FEN1/XRCC6	0.378593000845305
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/1123	87/9376	1.05562890860892	BIRC5/CYCS/PMAIP1/MYC/BAX/CTNNB1/BAK1/MAP2K2/AKT3/TP53/AKT1	0.192284943148627
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/1123	54/9376	1.08228620428086	CGA/HLA-G/HLA-DRA/HLA-E/CD28/HLA-DRB1/CD86	0.223686077510107
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/1123	112/9376	1.04363312555654	PPIF/HSPA8/CYCS/NFKBIA/HLA-DRA/LY96/IL10RB/MAPK13/HSPA6/HLA-DRB1/AKT3/TLR4/AKT1/IL10RA	0.171354555874448
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/1123	105/9376	1.03369376245601	PARP1/UBE2I/CD14/NFKBIA/LY96/CSNK2B/PLCG2/CCL4/CXCL8/TLR4/ICAM1/CXCL1/EDA	0.128070900300717
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/1123	157/9376	1.01039640181271	CD24/RAB17/UQCRFS1/C1QA/BSG/ARG2/CEBPB/STAB1/C1QB/C1QC/PPARG/RAB5C/SIRPA/DUSP5/MAPK13/MAP2K2/CASP1/P2RY6/SLC66A1	0.0484574513915232
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	21/1123	174/9376	1.00764577639942	HSP90AB1/BAG2/HSPA8/HSPH1/DNAJA1/VCP/RAD23A/HSP90AA1/SSR2/DDOST/DNAJA2/UFD1/SEC61B/BAX/BAK1/ERP29/RAD23B/NGLY1/HSPA6/SVIP/CANX	0.0375512757736673
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/1123	107/9376	1.01437238371851	LDHB/GNAS/PRMT1/PPP4C/PGAM1/CALM3/LDHA/PDHB/FBP1/PDHA1/ADCY2/AKT3/AKT1	0.0551535974698842
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	19/1123	158/9376	1.00400148787718	RPS6/ATP6V1C2/SKP2/PRR5/ATP6V1B2/LAMTOR1/TBC1D7/LAMTOR5/RRAGA/CASTOR1/ATP6V1B1/RHEB/MAP2K2/EIF4E/IGF1/WDR24/AKT3/EIF4B/AKT1	0.0187111849199572
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/1123	116/9376	1.00764577639942	JAM3/VAV3/CTNNB1/CLDN19/ITGB2/MAPK13/PLCG2/MYL12A/CYBB/CLDN7/CYBA/ITGAM/ICAM1/ACTN4	0.0305643164815235
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/1123	83/9376	1.00591144631956	RBBP7/CBX4/CBX3/AURKB/HDAC1/EZH2/CSNK2B/TFDP1/SFMBT1/EED	0.019953745173493
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1123	32/9376	1.04363312555654	AKR1B1/UGP2/PGM1/GLB1	0.0911999272344747
Human Diseases	Immune disease	hsa05310	Asthma	4/1123	32/9376	1.04363312555654	PRG2/HLA-DRA/HLA-DRB1/FCER1G	0.0911999272344747
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1123	15/9376	1.11320866726031	HEXB/GLB1	0.161857854160416
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1123	15/9376	1.11320866726031	AK2/NTPCR	0.161857854160416
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1123	76/9376	0.988705066316727	DBI/PLIN2/SLC27A2/CPT2/PLTP/PPARG/OLR1/ANGPTL4/FABP7	-0.0364685588183945
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1123	59/9376	0.990567034426551	GNAS/PLAAT3/CGA/ADRB1/ADCY2/AKT3/AKT1	-0.0268105548131232
NA	NA	hsa04517	IgSF CAM signaling	35/1123	299/9376	0.977315301524524	ARPC2/ARPC1B/ARPC5/TUBA1C/TUBA1B/JAM3/ARPC3/VAV3/TUBB/CTNNB1/ITGB2/TUBB4B/MTSS1/MAPK13/CD28/PLCG2/MYL12A/MAP2K2/DYNLL2/PARD6A/CD86/AKT3/PPFIA1/DOK1/CD84/TJP2/ITGAM/ARPC1A/ICAM1/CNTNAP2/ACTN4/PAK6/AKT1/FGFR1/DOK2	-0.147050677997646
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/1123	103/9376	0.972706602460469	GNAS/C1QA/C1QB/C1QC/NFKBIA/CCL3/FADD/MAPK13/CXCL8/AKT3/TLR4/AKT1	-0.102739081122188
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1123	16/9376	1.04363312555654	MIF/GOT1	0.0644329453932828
Human Diseases	Substance dependence	hsa05034	Alcoholism	22/1123	191/9376	0.961672408889801	GNAS/GNG5/H4C3/SLC29A1/H2AZ1/PPP1CA/CALM3/H3-3A/PPP1CC/H2AX/HDAC1/GNG12/H3C2/SLC29A2/CRH/H2AC16/H3C8/HDAC3/PKIA/H3C7/H2BC9/H2AC12	-0.197405033278703
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1123	79/9376	0.951159304304699	CLTA/ATP6V1C2/AP2M1/ATP6V1B2/ATP6V0A4/ATP6V0C/ATP6V1B1/ATP6V0D1/ATP6V0E2	-0.160802784721445
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/1123	44/9376	0.948757386869586	GTF2A2/TAF10/GTF2H5/TAF9B/TAF9	-0.12567237874739
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1123	17/9376	0.982242941700278	HSD17B4/ACOT8	-0.0270302679827285
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1123	17/9376	0.982242941700278	TXNRD1/SEPHS2	-0.0270302679827285
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1123	17/9376	0.982242941700278	CA8/GLUL	-0.0270302679827285
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/1123	133/9376	0.941623872682597	FOXO4/PRMT1/SKP2/CCNB2/CCNB1/CAT/PLK1/GABARAP/MAPK13/MAP2K2/CDKN1B/BCL6/IGF1/AKT3/AKT1	-0.250106062006483
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/1123	63/9376	0.927673889383596	ECHS1/ALDH7A1/EZH2/ALDH9A1/HADH/KMT5A/HYKK	-0.212466360347161
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1123	27/9376	0.927673889383596	ECHS1/ACADS/HADH	-0.138823825292569
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1123	27/9376	0.927673889383596	HSD17B4/ELOVL4/ACOT4	-0.138823825292569
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/1123	90/9376	0.927673889383596	CAT/PPARG/BAX/RHEB/EIF4E/IGF1/ADCY2/AKT3/TP53/AKT1	-0.254314791305606
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	38/1123	333/9376	0.952746156664233	CCNE1/GNAS/SPP1/ATP6V1C2/CCND3/PSMC1/CCNA2/RBPJ/HLA-G/HDAC1/BAX/ATP6V1B2/RB1/ATP6V0A4/CTNNB1/HLA-E/CDK4/COL2A1/E2F1/FADD/BAK1/ATP6V0C/PRKCZ/ATP6V1B1/RHEB/MAP2K2/CCNE2/CDKN1B/TLR3/PARD6A/MX2/AKT3/ATP6V0D1/ATP6V0E2/TP53/AKT1/TADA3/HES6	-0.323871387777883
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1123	18/9376	0.927673889383596	PRDX1/CD320	-0.113294659146945
Organismal Systems	Immune system	hsa04611	Platelet activation	14/1123	126/9376	0.927673889383596	GNAS/VAMP8/PPP1CA/PPP1CC/FCGR2A/MAPK13/PLCG2/PRKCZ/MYL12A/ADCY2/AKT3/TBXAS1/FCER1G/AKT1	-0.301494303725278
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/1123	73/9376	0.91496602788519	MGST3/GSTP1/ADH5/GSTO1/GSTA4/GSTA3/GSTT1/HPGDS	-0.269036980266731
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1123	65/9376	0.899130077402562	SPP1/CGA/ARRB1/MAP2K2/ARRB2/AKT3/AKT1	-0.301016149674282
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/1123	101/9376	0.909304109395802	BAX/CDK4/MAPK13/PLCG2/PRKCZ/CYBB/CDKN1B/CXCL8/AKT3/ICAM1/AKT1	-0.338034425608221
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1123	19/9376	0.87884894783709	HEXB/GLB1	-0.194986825931765
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/1123	38/9376	0.87884894783709	UGP2/HEXB/PGM1/GNPDA1	-0.276033408066104
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1123	38/9376	0.87884894783709	PNP/QPRT/NADK/NAPRT	-0.276033408066104
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1123	38/9376	0.87884894783709	UNG/RFXANK/CD4/TAP1	-0.276033408066104
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1123	29/9376	0.863696379770934	TEAD4/RASSF4/AJUBA	-0.271168889291841
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/1123	120/9376	0.904482042149006	BEX3/CALM3/NFKBIA/BAX/YWHAE/MAGED1/MAPK13/PLCG2/MAP2K2/SH2B2/AKT3/TP53/AKT1	-0.388448610782491
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/1123	94/9376	0.888198404728974	S100A9/HSP90AB1/CEBPB/HSP90AA1/NFKBIA/MAPK4/FADD/MAPK13/CXCL8/CXCL1	-0.401847007899814
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	11/1123	104/9376	0.88307418316323	PLAAT3/PHOSPHO1/PISD/LPCAT3/LYPLA2/LYPLA1/CHPT1/GPD1L/PLD2/PTDSS1/AGPAT5	-0.442292896610852
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/1123	50/9376	0.834906500445236	CR1/ITGB2/CXCL8/TLR4/ICAM1	-0.431754491246946
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/1123	69/9376	0.847006594654587	VAV3/MAPK13/PLCG2/MAP2K2/AKT3/FCER1G/AKT1	-0.470502562970319
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1123	31/9376	0.807974032688938	ALDH7A1/AKR1A1/ALDH9A1	-0.395021514135816
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1123	31/9376	0.807974032688938	SEC11A/SEC61B/SRP9	-0.395021514135816
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/1123	142/9376	0.881943486385813	PPARG/SIRPA/NFKBIA/FCGR2A/MAPK13/PLCG2/SPI1/TYROBP/FCGR3A/CYBA/FCGR1A/AKT3/LILRB5/AKT1/FCGR2B	-0.522888131776579
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/1123	160/9376	0.887088156723063	JAM3/HLA-G/SIGLEC1/HLA-DRA/CLDN19/HLA-E/ITGB2/VSIR/CD28/CLDN7/CDH3/CD4/HLA-DRB1/CD86/ITGAM/ICAM1/CNTNAP2	-0.531371000732237
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/1123	70/9376	0.834906500445236	FH/ELOC/MAP2K2/AKT3/EGLN2/PAK6/AKT1	-0.511407465130546
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/1123	89/9376	0.844287472360351	GNAS/TUBA1C/TUBA1B/CDK1/TUBB/ADRB1/TUBB4B/MAP2K2/ADCY2	-0.544440505906373
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/1123	61/9376	0.821219508634658	MT2A/SLC40A1/FTH1/SLC34A2/HMOX1/HMOX2	-0.516729443107314
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/1123	80/9376	0.834906500445236	RPS6/BAX/PLCG2/MAP2K2/EIF4E/IGF1/AKT3/AKT1	-0.547011558635121
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/1123	90/9376	0.834906500445236	NFKBIA/CSNK2B/MAPK13/CD28/MAP2K2/CD4/AKT3/TLR4/AKT1	-0.580505691891292
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/1123	100/9376	0.834906500445236	CD24/CSF2RA/CR1/CD14/HLA-DRA/CD4/HLA-DRB1/FCGR1A/ITGAM/IL2RA	-0.612236471470418
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/1123	33/9376	0.759005909495669	VAMP8/BNIP1/SNAP29	-0.51155199477526
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1123	23/9376	0.726005652561075	LARGE2/B4GAT1	-0.485288106762094
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1123	23/9376	0.726005652561075	MDH1/SLC25A10	-0.485288106762094
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1123	12/9376	0.695755417037697	COQ2	-0.389002478758855
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1123	12/9376	0.695755417037697	FCGR2B	-0.389002478758855
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/1123	138/9376	0.847006594654587	RPS6/PPP1CA/CALM3/PPP1CC/FLOT2/FBP1/PRKCZ/RHEB/MAP2K2/EIF4E/CBL/SH2B2/AKT3/AKT1	-0.667871435522913
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/1123	130/9376	0.834906500445236	GNAS/GNG5/ARRB1/NFKBIA/GNG12/RLN2/MAPK13/PRKCZ/MAP2K2/ARRB2/ADCY2/AKT3/AKT1	-0.699188535996808
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/1123	194/9376	0.86072835097447	TUBA1C/TUBA1B/DYNLRB1/TUBB/TNNC1/MYO7A/CAPZB/KIF2C/TNNI2/TUBB4B/MYL12A/KIF4A/KIF23/DYNLL2/MYO1F/KIF11/TNNT3/KIFC1/KIF18A/KIF20A	-0.723043676627763
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1123	24/9376	0.695755417037697	GLCE/HS6ST2	-0.550485418865957
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	21/1123	204/9376	0.859462573987743	RPS6/HCLS1/PPP1CA/VAV3/PPP1CC/MYC/CTNNB1/DDX5/PDCD4/TFAP4/MAPK13/PLCG2/MAP2K2/CBL/IGF1/AKT3/TLR4/EIF4B/TP53/AKT1/FGFR1	-0.748591082780942
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1123	56/9376	0.745452232540389	DDOST/MGAT5/ALG2/ST6GAL1/ALG8	-0.704733543784781
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/1123	86/9376	0.776657209716499	MYC/PLCG2/MAP2K2/CDKN1B/CBL/AKT3/PAK6/AKT1	-0.767507980603989
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	11/1123	115/9376	0.798606217817182	GNAS/NACA/GCM1/ARRB1/SLC34A2/ARRB2/PLD2/MEF2C/ADCY2/MMP15/FGFR1	-0.80155924936789
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/1123	144/9376	0.811714653210646	DUSP9/DLX5/ISL1/MYC/CTNNB1/TBX3/ID3/MAPK13/ID2/MAP2K2/IGF1/AKT3/AKT1/FGFR1	-0.839884302817401
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1123	26/9376	0.642235769573258	SLC19A1/SLC52A3	-0.673825402811318
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/1123	37/9376	0.676951216577218	UGP2/NANS/PGM1	-0.726253733428754
NA	NA	hsa03272	Virion - Hepatitis viruses	4/1123	48/9376	0.695755417037697	CLDN19/CLDN7/CHMP1A/CHMP4A	-0.779504807815906
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	18/1123	183/9376	0.821219508634658	RAN/NHP2/SNU13/NOB1/EMG1/NOP56/RPP25L/POP7/RPP30/NXT1/CSNK2B/FBL/BMS1/EIF6/DKC1/UTP6/RBM28/IMP4	-0.900920844288124
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/1123	99/9376	0.759005909495669	GNAS/PPP1CA/CALM3/PPP1CC/CYP2J2/MAPK13/PLCG2/IGF1/ADCY2	-0.889180246289209
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/1123	166/9376	0.804729157055649	SLC25A5/SLC25A6/PPIF/VDAC1/PPP1CA/CALM3/PPP1CC/VDAC3/ADRB1/RGS2/MAP2K2/MEF2C/ADCY2/AKT3/SLC25A4/AKT1	-0.936334927130532
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	15/1123	157/9376	0.797681369852136	CCND3/BIRC5/BMP7/PPP1CA/PPP1CC/MYC/YWHAB/YWHAE/CTNNB1/ITGB2/ID2/PRKCZ/TEAD4/PARD6A/AJUBA	-0.943003681716868
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/1123	60/9376	0.695755417037697	MAPK13/PLCG2/MAP2K2/AKT3/AKT1	-0.87207398958353
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/1123	60/9376	0.695755417037697	GNAS/CRH/MAP2K2/IGF1/RYR1	-0.87207398958353
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/1123	148/9376	0.789776419340088	MYC/BAX/RB1/CTNNB1/CDK4/E2F1/E2F3/BAK1/MAP2K2/IGF1/AKT3/TP53/AKT1/FGFR1	-0.95088519921372
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1123	50/9376	0.667925200356189	HLA-DRA/CD28/HLA-DRB1/CD86	-0.868445980991431
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/1123	91/9376	0.733983736655152	VAV3/NFKBIA/PLCG2/MAP2K2/AKT3/LILRB5/AKT1/FCGR2B	-0.940605523363446
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/1123	71/9376	0.70555478910865	CGA/ELF5/MAPK13/MAP2K2/AKT3/AKT1	-0.91863941314964
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1123	16/9376	0.521816562778272	HEXB	-0.70613248318761
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	14/1123	150/9376	0.77924606708222	CCNE1/MYC/BAX/RB1/CTNNB1/E2F1/E2F3/BAK1/MAP2K2/CCNE2/CDKN1B/AKT3/TP53/AKT1	-1.00534922577747
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	16/1123	169/9376	0.790444024090164	UBA52/RPS27A/UBB/HMGB1/VAMP8/RAB8A/AMBRA1/GABARAP/IGBP1/RRAGA/RHEB/MAP2K2/CTSB/SNAP29/AKT3/AKT1	-1.01403728693204
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/1123	122/9376	0.75278454958177	MYC/DIO2/HDAC1/CTNNB1/PLCG2/RHEB/MAP2K2/AKT3/HDAC3/TP53/AKT1	-1.01381887197075
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/1123	93/9376	0.718199140167945	RBPJ/NFKBIA/HLA-DRA/MAF/MAPK13/CD4/HLA-DRB1/IL2RA	-1.00741684107932
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1123	17/9376	0.491121470850139	CDO1	-0.774628476260197
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/1123	133/9376	0.753299098146078	GNAS/COMT/GNG5/PPP1CA/CALM3/PPP1CC/ARRB1/GNG12/MAPK13/ARRB2/AKT3/AKT1	-1.05696273273918
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1123	30/9376	0.556604333630157	PGAP2/PIGC	-0.897240310348015
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1123	30/9376	0.556604333630157	PLAAT3/CYP2J2	-0.897240310348015
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/1123	105/9376	0.715634143238774	CALM3/NFKBIA/PYCARD/MAPK13/PLCG2/CASP1/AKT3/FCER1G/AKT1	-1.080882294987
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/1123	125/9376	0.734717720391808	S1PR2/BAX/BID/MAPK13/PRKCZ/MAP2K2/PLD2/AKT3/FCER1G/TP53/AKT1	-1.10138333435228
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/1123	75/9376	0.667925200356189	GNAS/GPX3/CGA/GSR/ADCY2/CANX	-1.06505325150995
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	14/1123	155/9376	0.754109097176342	CCNE1/GNAS/FH/CYP11A1/RB1/CTNNB1/CDK4/E2F1/CRH/E2F3/MAP2K2/CCNE2/CDKN1B/ADCY2	-1.13864644190504
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/1123	65/9376	0.642235769573258	AKR1B1/ALDH7A1/AKR1A1/ALDH9A1/AGPAT5	-1.06764046567213
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/1123	32/9376	0.521816562778272	GABARAP/IGBP1	-0.999476753569651
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/1123	44/9376	0.569254432121752	HEXB/DDOST/ALG2	-1.05640241281969
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/1123	44/9376	0.569254432121752	GNAS/RAB5C/DYNLL2	-1.05640241281969
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/1123	149/9376	0.728441913140139	GNAS/LPAR6/PLCG2/RHEB/MAP2K2/CYTH4/PLD2/ADCY2/CXCL8/AKT3/FCER1G/AKT1/AGPAT5	-1.23252349865938
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/1123	140/9376	0.715634143238774	RPS6/SPP1/GNG5/TFAM/CALM3/GNG12/MAP2K2/MEF2C/ADCY2/AKT3/RYR1/AKT1	-1.25045797250403
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1123	20/9376	0.417453250222618	DHCR24	-0.961989359953481
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/1123	100/9376	0.667925200356189	CCL3/IL10RB/CCL4/CXCL8/IL2RA/TNFRSF14/CXCL1/IL10RA	-1.23147370518203
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/1123	69/9376	0.605004710467562	GNAS/PPP1CA/CALM3/PPP1CC/HDAC1	-1.2147340316181
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/1123	122/9376	0.684349590528882	CCNA2/PPARG/EEF2/LEP/RAB8A/FBP1/RHEB/IGF1/AKT3/AKT1	-1.29446740293023
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	10/1123	122/9376	0.684349590528882	VAV3/NFKBIA/CDK4/MAPK13/CD28/MAP2K2/CD4/AKT3/PAK6/AKT1	-1.29446740293023
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/1123	91/9376	0.642235769573258	GNAS/GNG5/ARRB1/GNG12/ARRB2/ADCY2/GRK3	-1.26501668345378
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1123	21/9376	0.397574524021541	BCAT2	-1.01943766343409
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1123	35/9376	0.477089428825849	AKR1B1/FBP1	-1.1432319455814
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/1123	133/9376	0.690524173300571	VAV3/HLA-G/BID/HLA-E/ITGB2/PLCG2/MAP2K2/TYROBP/FCGR3A/ICAM1/FCER1G	-1.32591495631674
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	19/1123	212/9376	0.748265259832995	GNAS/PFN1/FLT1/VAV3/CALM3/CTNNB1/ITGB2/MAPK13/PRKCZ/PGF/MAP2K2/EFNA4/PARD6A/IGF1/ADCY2/AKT3/ITGAM/AKT1/FGFR1	-1.36753401559081
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/1123	193/9376	0.735409870858498	GNG5/VAV3/ARRB1/NFKBIA/CCL3/GNG12/PLCG2/PRKCZ/CCL4/PREX1/ARRB2/ADCY2/CXCL8/AKT3/GRK3/AKT1/CXCL1	-1.37002847707335
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	21/1123	232/9376	0.755734332299567	PFN1/ARPC2/CFL1/ARPC1B/ARPC5/ARPC3/PPP1CA/VAV3/PPP1CC/GNG12/ITGB2/MYL12A/MAP2K2/AKT3/ITGAM/ARPC1A/ACTN4/PAK6/AKT1/FGFR1/TMSB4Y	-1.38965792138905
NA	NA	hsa04518	Integrin signaling	13/1123	154/9376	0.70479120167455	SPP1/CCND3/FLT1/CTNNB1/ITGB2/COL2A1/PGF/IGF1/AKT3/ITGAM/ICAM1/ACTN4/AKT1	-1.36253194171527
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/1123	93/9376	0.628424247646952	GNAS/CGA/CALM3/MAPK13/MAP2K2/PLD2/ADCY2	-1.32835531758232
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1123	36/9376	0.463836944691798	UGP2/PGM1	-1.18889716473593
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/1123	72/9376	0.579796180864747	NFKBIA/FADD/MAPK13/CXCL8/IRF7	-1.32026462321575
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/1123	49/9376	0.511167245170553	GALNT11/ST6GAL1/FUT10	-1.26548483182018
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/1123	37/9376	0.451300811051479	ICAM1/APOL1	-1.2335438328572
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1123	23/9376	0.363002826280537	ENPEP	-1.12822456133344
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	15/1123	178/9376	0.703572893633626	SERPINF1/NOTUM/CCND3/SIAH1/TBL1X/RUVBL1/MYC/CACYBP/CTNNB1/CSNK2B/ZNRF3/CBY1/TLE2/TBL1Y/TP53	-1.47282384539677
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1123	51/9376	0.491121470850139	PLAAT3/CHPT1/PLD2	-1.34413963946483
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/1123	63/9376	0.530099365362054	BAX/CTNNB1/BAK1/TP53	-1.3803877564474
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/1123	139/9376	0.660717374453064	GNAS/HSP90AB1/HSPA8/CALM3/HSP90AA1/FKBP4/MAP2K2/HSPA6/ADCY2/AKT3/AKT1	-1.48652816579088
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/1123	109/9376	0.612775413170815	HSP90AB1/HSP90AA1/NFKBIA/HLA-DRA/MAPK13/CD4/HLA-DRB1/IL2RA	-1.49994794138119
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/1123	99/9376	0.590337929607743	LYPLA1/CHPT1/RHEB/MAP2K2/PLD2/AKT3/AKT1	-1.51150353888113
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/1123	110/9376	0.607204727596535	E2F4/BMP7/MYC/E2F5/HDAC1/TFDP1/ID3/ID2	-1.52857249441495
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/1123	53/9376	0.472588585157681	GNAS/CLTA/AP2M1	-1.42029713672402
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1123	26/9376	0.321117884786629	PLAAT3	-1.27862982333199
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/1123	66/9376	0.506003939663779	HLA-DRA/MAF/HLA-DRB1/TLR4	-1.4855600318952
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/1123	154/9376	0.650576493853431	GNAS/PPP1CA/CALM3/PPP1CC/TNNC1/ADRB1/CREM/MAPK13/ADCY2/AKT3/SCN1B/AKT1	-1.61275914204281
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/1123	67/9376	0.498451642056857	PPP1CA/CALM3/PPP1CC/MAP2K2	-1.51973649534919
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/1123	56/9376	0.447271339524234	ARRB1/ARRB2/GRK3	-1.53026848962762
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/1123	69/9376	0.48400376837405	GNAS/CALM3/ADRB1/CTSB	-1.58684976594199
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/1123	70/9376	0.477089428825849	NFKBIA/LEP/AKT3/AKT1	-1.61981162441487
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1123	29/9376	0.287898793256978	CALM3	-1.41668792781417
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/1123	45/9376	0.371069555753438	ABCG2/TAP1	-1.55996327353735
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/1123	203/9376	0.658054384587378	SPP1/CCND3/FLT1/PPP1CA/VAV3/PPP1CC/CTNNB1/COL2A1/MYL12A/PGF/IGF1/AKT3/ACTN4/ZYX/PAK6/AKT1	-1.81684950688165
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/1123	119/9376	0.561281680971587	CEBPB/NFKBIA/FADD/MAPK13/AKT3/ICAM1/AKT1/CXCL1	-1.77661658376626
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/1123	97/9376	0.516437010584682	GNAS/GNG5/CALM3/GNG12/ADCY2/RYR1	-1.76586674234309
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/1123	109/9376	0.536178486524464	SLC27A2/PPP1CA/PPP1CC/NFKBIA/PRKCZ/AKT3/AKT1	-1.79665276423378
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/1123	47/9376	0.35527936189159	PRKCZ/MAFA	-1.63445342225711
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/1123	154/9376	0.596361786032311	GNAS/PPP1CA/CALM3/PPP1CC/EEF2/RGS2/MAP2K2/MEF2C/TRPM2/ADCY2/RYR1	-1.86298634237035
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/1123	122/9376	0.547479672423106	GNAS/MAPK13/PLCG2/MAP2K2/IGF1/ADCY2/AKT3/AKT1	-1.8557644648492
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/1123	48/9376	0.347877708518848	AKT3/AKT1	-1.67080201246004
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/1123	62/9376	0.403987016344469	RBPJ/HDAC1/TLE2	-1.73681292473097
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/1123	89/9376	0.469048595755751	GNG5/GABARAP/GNG12/GLUL/ADCY2	-1.85644312323675
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	31/1123	362/9376	0.71497517993929	CCNE1/RPS6/HSP90AB1/SPP1/GNG5/CCND3/FLT1/HSP90AA1/MYC/CDC37/YWHAB/YWHAE/GNG12/LPAR6/CDK4/COL2A1/RHEB/PGF/MAP2K2/CCNE2/EFNA4/CDKN1B/EIF4E/IGF1/AKT3/TLR4/EIF4B/IL2RA/TP53/AKT1/FGFR1	-2.04008274377313
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/1123	34/9376	0.245560735425069	BHLHE41	-1.62559892673307
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/1123	78/9376	0.428157179715506	ISYNA1/IMPA2/PLCG2/PI4K2B	-1.87067695828594
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/1123	65/9376	0.385341461743955	GNAS/CYP11A1/ADCY2	-1.83426478166997
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1123	66/9376	0.379502954747835	COMT/HSD17B1/CYP11A1	-1.86597765518272
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/1123	116/9376	0.503822888199711	GNAS/GNG5/GNG12/GLUL/PLD2/ADCY2/GRK3	-1.98348911656603
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/1123	36/9376	0.231918472345899	GALNT11	-1.70315716734545
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/1123	105/9376	0.477089428825849	GNAS/SSPN/TNNC1/ADRB1/IGF1/ADCY2	-1.98759719145278
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/1123	93/9376	0.448874462604966	CTNNB1/CSNK2B/MYL12A/ACTN4/FGFR1	-1.97023227058831
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	24/1123	300/9376	0.667925200356189	DUSP9/STMN1/HSPA8/FLT1/ARRB1/MYC/CD14/GNG12/MAP3K20/DUSP5/MAPK13/PGF/MAP2K2/ARRB2/EFNA4/ECSIT/MEF2C/HSPA6/IGF1/AKT3/TP53/AKT1/FGFR1/DAXX	-2.15634823077315
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	26/1123	323/9376	0.672060960110716	CCNE1/DNMT1/STMN1/UBE2I/CDCA5/MYC/HNRNPK/HDAC1/CCNG1/EZH2/CDC25A/HMOX1/E2F1/PDCD4/E2F3/BAK1/PLCG2/MAP2K2/ST14/CCNE2/EFNA4/KIF23/CDKN1B/SOX4/TP53/CDC25C	-2.21242071227676
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/1123	38/9376	0.219712236959273	IGF1	-1.77782600034529
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/1123	55/9376	0.303602363798268	HEXB/GLB1	-1.91063167288836
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/1123	238/9376	0.596361786032311	FOXO4/PLAAT3/GNG5/FLT1/CALM3/RAB5C/GNG12/PLCG2/PGF/MAP2K2/EFNA4/PLD2/IGF1/AKT3/PAK6/AKT1/FGFR1	-2.32661632617063
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/1123	101/9376	0.413320049725364	GNAS/CALM3/CTNNB1/MAP2K2/ADCY2	-2.18662630341672
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/1123	76/9376	0.329568355438909	GNAS/CALM3/ADCY2	-2.16465864687609
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/1123	90/9376	0.371069555753438	GNAS/EPHX1/ABCG2/ADCY2	-2.21146019481972
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/1123	254/9376	0.591666023937569	SLC25A5/SLC25A6/GNAS/PPIF/TFEB/VDAC1/FLT1/CALM3/TNNC1/VDAC3/ADRB1/P2RX4/PLCG2/PTAFR/ADCY2/SLC25A4/RYR1/FGFR1	-2.43364336640958
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/1123	93/9376	0.359099570083972	GNAS/CALM3/ADRB1/ADCY2	-2.29117074709131
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/1123	49/9376	0.170389081723518	GNAS	-2.14768757416346
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/1123	98/9376	0.340778163447035	IMPA2/CALM3/PLCG2/PI4K2B	-2.41984212291342
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/1123	98/9376	0.340778163447035	GNAS/CALM3/CYP11A1/ADCY2	-2.41984212291342
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1123	68/9376	0.245560735425069	ADH5/RDH13	-2.30313898088171
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/1123	115/9376	0.363002826280537	GNG5/GNG12/ADCY2/AKT3/AKT1	-2.53528669496134
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/1123	226/9376	0.517198717089969	GNAS/CGA/PPP1CA/VAV3/CALM3/PPP1CC/NFKBIA/ADRB1/CRH/MAP2K2/PLD2/ADCY2/AKT3/AKT1	-2.7100773202983
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/1123	168/9376	0.447271339524234	CCND3/CSF2RA/MYC/LEP/IL10RB/AKT3/IL2RA/AKT1/IL10RA	-2.66657353065838
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/1123	89/9376	0.28142915745345	SPP1/HMMR/COL2A1	-2.51244443190194
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/1123	184/9376	0.453753532850672	CFL1/BMP7/PLCG2/PRKCZ/MYL12A/EFNA4/SEMA4B/PARD6A/PAK6/SEMA4C	-2.76033720220405
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/1123	134/9376	0.373838731542643	GNAS/PPP1CA/CALM3/PPP1CC/MAP2K2/ADCY2	-2.69293091118329
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/1123	99/9376	0.25300196983189	SSPN/TNNC1/IGF1	-2.75615012406496
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/1123	115/9376	0.29040226102443	GNAS/GNG5/CYP2J2/GNG12	-2.82424126922691
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	13/1123	233/9376	0.465827661192621	CSRP2/FBLN1/LMNB1/SSPN/LMNB2/TNNC1/PDLIM1/CAPZB/BGN/TNNI2/ENO1/TNNT3/ZYX	-3.04568223038231
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/1123	102/9376	0.245560735425069	GNAS/RAB8A/ADCY2	-2.82592360379834
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/1123	86/9376	0.194164302429125	GNAS/ADCY2	-2.76922003238229
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/1123	86/9376	0.194164302429125	SSPN/CTNNB1	-2.76922003238229
NA	NA	hsa04081	Hormone signaling	11/1123	219/9376	0.419359429447379	GNAS/SLC40A1/GNG5/CGA/DIO2/LEP/GNG12/ADRB1/CRH/IGF1/ADCY2	-3.2071732556225
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/1123	103/9376	0.162117767076745	COL14A1/COL2A1	-3.15399541498863
NA	NA	hsa04519	Cadherin signaling	25/1123	404/9376	0.516650062156705	ARPC2/ARPC1B/ARPC5/KRT7/ARPC3/PPP1CA/VAV3/PPP1CC/NFKBIA/YWHAB/YWHAE/MYO7A/CTNNB1/CIB2/MAPK13/PCDH12/MAP2K2/TEAD4/CDH3/MYO1F/AJUBA/ARPC1A/SCN1B/ACTN4/FGFR1	-3.6633406993447
NA	NA	hsa04082	Neuroactive ligand signaling	8/1123	199/9376	0.33564080419909	GNAS/GNG5/GNG12/ADRB1/OGFRL1/P2RX4/P2RY6/ADCY2	-3.49420770348858
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1123	86/9376	0.0970821512145623	SCN9A	-3.10283870767868
NA	NA	hsa04382	Cornified envelope formation	8/1123	217/9376	0.307799631500548	S100A9/KRT7/BLMH/EPHX2/ELOVL4/CLDN19/ST14/CLDN7	-3.80546084128063
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	14/1123	298/9376	0.392237953229305	BMP7/CSF2RA/LEP/CCL3/GDF15/IL10RB/CCL4/CD4/CXCL8/IL2RA/TNFRSF14/CXCL1/IL10RA/EDA	-3.9329299626355
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/1123	370/9376	0.315910567736035	CGA/S1PR2/LEP/TMEM97/LPAR6/ADRB1/OGFRL1/P2RX4/CRH/C3AR1/RLN2/CHRNA5/PTAFR/P2RY6	-4.95241882823654
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/1123	449/9376	0.0929739978224094	CALM3/ARRB1/RGS2/ARRB2/GRK3	-7.26540342434351