category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	33/669	82/9376	5.64016187247074	HLA-E/HLA-C/HLA-A/HSP90AA1/HLA-B/PSME1/HSPA1A/HLA-F/HSP90AB1/PSME2/TAPBP/HLA-DRA/CTSB/HSPA1B/HSPA8/CANX/HLA-DRB1/TAP1/IFI30/HLA-G/B2M/TNF/HLA-DPA1/LGMN/HLA-DPB1/CTSL/HLA-DMA/HSPA2/TAP2/HSPA4/HLA-DQA1/HSPA6/HLA-DMB	11.6977718888371
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	46/669	224/9376	2.87806961349562	HLA-E/HLA-C/HLA-A/JUN/HLA-B/HLA-F/ZFP36/EGR1/HLA-DRA/GPS2/FOS/CANX/NFKBIA/HLA-DRB1/HLA-G/B2M/LTA/ATF4/TNF/HLA-DPA1/CCND2/MAD1L1/MYC/HLA-DPB1/PRKACA/CDKN1A/HLA-DMA/HRAS/NFKB2/ATF6B/HLA-DQA1/CCNE1/MSX2/PTEN/HLA-DMB/ICAM1/TNFRSF13C/EGR2/PPP3R1/CRTC2/NRP1/SPI1/AKT3/PIK3R3/SLC2A1/E2F1	7.88573383400804
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	38/669	180/9376	2.95871117754526	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/TAPBP/HLA-DRA/TNFRSF14/NFKBIA/HLA-DRB1/TAP1/CCL5/HLA-G/B2M/LTA/DAXX/TNF/HLA-DPA1/SRSF2/HLA-DPB1/IRF7/IRF9/HLA-DMA/TAP2/IFNGR2/SRSF3/NXF1/HLA-DQA1/ITGA5/SRSF1/HLA-DMB/CCL2/SRSF6/CGAS/AKT3/PIK3R3/FADD/SRSF7	7.35481236895723
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	41/669	205/9376	2.80298953662182	HLA-E/HLA-C/HLA-A/PLCG2/JUN/HLA-B/HLA-F/TAPBP/HLA-DRA/NFKBIA/HLA-DRB1/PSMC4/TAP1/NFKBIB/HLA-G/B2M/GADD45B/TNF/HLA-DPA1/CCND2/MYC/HLA-DPB1/IRF7/CDKN1A/IRF9/HLA-DMA/NFKB2/TAP2/NFKBIE/HLA-DQA1/GADD45G/CCNE1/HLA-DMB/ICAM1/HES1/AKT3/PIK3R3/FADD/E2F1/BTK/MAP2K3	7.23479475438324
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	34/669	155/9376	3.07424658855297	HLA-E/HLA-C/HLA-A/HLA-B/ATP6V0C/HLA-F/TUBB/HLA-DRA/CANX/HLA-DRB1/TAP1/TUBB4B/HLA-G/HLA-DPA1/CD14/HLA-DPB1/CTSL/TUBA1B/HLA-DMA/MRC1/TAP2/HLA-DQA1/TUBB2A/FCGR2A/ITGA5/COLEC12/HLA-DMB/MSR1/TUBB4A/SCARB1/TUBA1A/OLR1/TUBA1C/NCF4	7.21774687592118
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	16/669	44/9376	5.09634461203968	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/HLA-DRA/HSPD1/HLA-DRB1/HLA-G/LTA/TNF/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/HLA-DMB	7.54918178435077
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	24/669	95/9376	3.54061836204862	JUN/LTB/ATP6V0C/CCL3/HLA-DRA/FOS/HLA-DRB1/FLT1/CCL5/TNF/HLA-DPA1/HLA-DPB1/CTSL/HLA-DMA/CCL3L1/HLA-DQA1/VEGFA/IL23A/HLA-DMB/ICAM1/CCL2/CCL20/ANGPT1/CXCL3	6.89871611222938
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	39/669	227/9376	2.40785444775884	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/CCL3/TAPBP/CCL4/NFKBIA/TAP1/CCL5/HLA-G/B2M/ATF4/TNF/MYC/CCL4L2/PRKACA/GNG10/CDKN1A/HRAS/ATF6B/TAP2/CCL3L1/IL10RB/VEGFA/ARHGEF1/PPP3R1/CCL2/CALML4/GNAS/GNAI1/CGAS/AKT3/PIK3R3/FADD/GNG12/PRKCG/E2F1	5.9517995588249
Human Diseases	Immune disease	hsa05330	Allograft rejection	14/669	39/9376	5.03100686060327	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/TNF/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/HLA-DMB	6.99208318175232
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	44/669	275/9376	2.24239162929746	HSPA1A/EGR1/TUBB/HSPA1B/CSNK2B/NDUFA3/PSMB3/HSPA8/NDUFA6/PSMA2/PSMC4/NDUFA7/C1QA/CCL5/PSMA6/TUBB4B/NDUFS3/ATF4/TNF/MT-CO1/MT-CO3/PRKACA/C1QB/C1QC/TUBA1B/NDUFS1/ATF6B/NDUFA13/STIP1/TUBB2A/HSPA6/MT-ND1/TUBB4A/PPP3R1/TUBA1A/MT-ATP6/PIK3R3/TUBA1C/NCF4/SDHA/MT-ND4/MT-ND5/PSMD9/MT-ND4L	5.79621826674049
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	37/669	216/9376	2.40070863090295	JUN/HSP90AA1/HSPA1A/HSP90AB1/CDC42/CCL3/HSPA1B/FOS/HSPA8/HSPD1/NFKBIA/CCL5/ATF4/TNF/CD14/IRF7/HRAS/HSPA2/HSPA4/CCL3L1/HSPA6/SOD2/RXRB/ARHGEF1/LDLR/ICAM1/PPP3R1/CCL2/CALML4/OLR1/AKT3/AGER/PIK3R3/CXCL3/NCF4/MAP2K3/ABCA1	5.77286455830283
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	35/669	205/9376	2.39279594589668	HLA-E/HLA-C/HLA-A/JUN/HLA-B/YWHAE/HLA-F/CDC42/CHD4/NFKBIA/HLA-G/ACTN4/ATF4/CCND2/MAD1L1/PRKACA/IRF7/GTF2H1/CDKN1A/DDX3X/IRF9/EGR3/HRAS/MRPS18B/NFKB2/ATF6B/DNAJA3/CCNE1/GTF2H4/EGR2/SCRIB/PMAIP1/REL/PIK3R3/IL6ST	5.58882489256126
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	45/669	300/9376	2.10224215246637	JUN/HSPA1A/NR4A1/CDC42/HSPA1B/FOS/HSPA8/DUSP8/FLT1/DUSP16/GADD45B/ATF4/DAXX/TNF/DUSP1/CD14/MYC/MKNK2/PRKACA/JUND/RPS6KA1/HRAS/NFKB2/DUSP9/CSF1R/PPM1B/GADD45G/HSPA6/EFNA1/VEGFA/FGFR1/DUSP2/PPP3R1/PDGFB/MAP4K1/ANGPT1/PLA2G4B/CACNA2D4/AKT3/GNG12/PRKCG/PGF/HSPB1/DUSP7/MAP2K3	5.37842137351618
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	14/669	45/9376	4.36020594585617	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/TNF/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/HLA-DMB	6.26285681881152
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	22/669	109/9376	2.8287050369578	JUN/HSP90AA1/IL27RA/HSP90AB1/HLA-DRA/FOS/NFKBIA/HLA-DRB1/NFKBIB/AHR/HLA-DPA1/HLA-DPB1/HLA-DMA/IFNGR2/NFKBIE/HLA-DQA1/EBI3/RXRB/IL23A/HLA-DMB/PPP3R1/IL6ST	5.32294223770974
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	32/669	196/9376	2.28815472377292	HLA-E/HLA-C/HLA-A/PLCG2/JUN/HLA-B/HLA-F/ZFP36/FOS/NFKBIA/HLA-G/UBB/MYC/GNG10/IRF7/CDKN1A/IRF9/HRAS/UBC/VEGFA/MICB/ICAM1/PPP3R1/PDGFB/CALML4/AKT3/PIK3R3/FADD/CXCL3/IL6ST/GNG12/E2F1	5.05171859632815
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	25/669	137/9376	2.55747220494692	JUN/CTSB/FOS/NFKBIA/GADD45B/ATF4/DAXX/TNF/MCL1/CTSL/TUBA1B/HRAS/LMNA/GADD45G/BBC3/CTSD/TUBA1A/PMAIP1/AKT3/CTSZ/PIK3R3/CSF2RB/CTSO/TUBA1C/FADD	5.09017284490255
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	39/669	268/9376	2.03948865537782	TUBB/NDUFA3/PSMB3/NDUFA6/PSMA2/PSMC4/NDUFA7/PSMA6/TUBB4B/NDUFS3/ATF4/UBB/DAXX/DUSP1/SLC39A1/MT-CO1/MT-CO3/PRKACA/TUBA1B/NDUFS1/SLC39A7/NDUFA13/TUBB2A/SLC39A4/UBC/MT-ND1/TUBB4A/TUBA1A/ADORA2A/CALML4/GNAS/GNAI1/MT-ATP6/TUBA1C/SDHA/MT-ND4/MT-ND5/PSMD9/MT-ND4L	4.78564043159046
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/669	54/9376	3.63350495488014	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/HLA-DMB/CGA	5.37948740796942
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	16/669	70/9376	3.20341661328208	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/EIF4G2/HLA-DMB/DMD/ICAM1	5.12895088605514
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	21/669	112/9376	2.62780269058296	HSPA1A/HLA-DRA/HSPA1B/HSPA8/NFKBIA/HLA-DRB1/NFKBIB/TNF/HLA-DPA1/HLA-DPB1/HLA-DMA/IFNGR2/HLA-DQA1/IL10RB/HSPA6/HLA-DMB/LDLR/GNAI1/AKT3/ALOX5/MAP2K3	4.80370052988299
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	26/669	157/9376	2.32094675006903	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/SQSTM1/ZFP36L1/HLA-G/GADD45B/CCND2/SERPINE1/MYC/CDKN1A/RAD50/HRAS/GADD45G/CCNE1/PTEN/PPP3R1/CALML4/CCNB1/AKT3/PIK3R3/E2F1/SIRT1/MAP2K3	4.62655419997802
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	23/669	133/9376	2.42363756925947	GABARAP/GADD45B/CCND2/CDKN1A/PLK3/HRAS/GADD45G/PTEN/SOD2/PRKAG1/PLK2/CSNK1E/FOXO4/SGK1/PCK2/CCNB1/AKT3/BCL6/PIK3R3/CCNG2/DEPP1/SGK3/SIRT1	4.58335196796134
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	16/669	78/9376	2.87486106320187	JUN/HLA-DRA/FOS/NFKBIA/HLA-DRB1/NFKBIB/TNF/HLA-DPA1/HLA-DPB1/HLA-DMA/IFNGR2/HLA-DQA1/MARCKSL1/FCGR2A/HLA-DMB/NCF4	4.60878071637777
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/669	103/9376	2.58528161144731	JUN/CCL3/FOS/NFKBIA/C1QA/CCL5/PPP2CA/TNF/SERPINE1/C1QB/C1QC/IFNGR2/CCL3L1/CCL2/GNAS/GNAI1/AKT3/PIK3R3/FADD	4.48414171438981
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/669	110/9376	2.42076369071885	LDHA/PLCG2/EGLN2/FLT1/SERPINE1/MKNK2/CDKN1A/EPAS1/IFNGR2/EGLN1/HMOX1/VEGFA/ANGPT1/AKT3/PIK3R3/SLC2A1/LDHC/PRKCG/EGLN3	4.15466937936215
Human Diseases	Immune disease	hsa05310	Asthma	9/669	32/9376	3.94170403587444	PRG2/HLA-DRA/HLA-DRB1/TNF/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/HLA-DMB	4.62031914826569
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	22/669	139/9376	2.2181931584777	JUN/HSP90AA1/HSPA1A/HSP90AB1/HSPA1B/FOS/HSPA8/ATF4/FKBP4/PRKACA/HRAS/ATF6B/HSPA6/HBEGF/KRT18/CTSD/CALML4/GNAS/GNAI1/AKT3/PIK3R3/KRT19	4.01072152940066
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/669	115/9376	2.3155130954702	EGR1/FOS/ATF4/PRKACA/JUND/CDKN1A/ATF6B/MAFB/RXRB/ARHGEF1/HBEGF/FGFR1/SGK1/GNAS/GNAI1/MMP14/GCM1/LRP6/PRKCG	3.93440966833512
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/669	56/9376	3.00320307495195	EEF1G/HSPA1A/HSPA1B/HSPA8/HSPD1/NFKBIA/TNF/HSF1/CD14/NFKB2/HSPA6/CXCL3	4.16749857845126
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	29/669	214/9376	1.89922188229049	HLA-E/HLA-C/HLA-A/PLCG2/JUN/HLA-B/HLA-F/TAPBP/FOS/NFKBIA/TAP1/SKP1/HLA-G/B2M/TNF/GNG10/HRAS/TAP2/PPP3R1/CALML4/CCNB1/GNAI1/CGAS/AKT3/PIK3R3/FADD/GNG12/PRKCG/MAP2K3	3.68844264487264
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/669	119/9376	2.23768072251322	JUN/FOS/NFKBIA/CCL5/LTA/ATF4/TNF/ATF6B/ICAM1/CCL2/CEBPB/CCL20/MMP14/AKT3/PIK3R3/FADD/CXCL3/PGAM5/MAP2K3	3.76626956128125
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/669	101/9376	2.35895159022629	PLCG2/JUN/FN1/EGR1/CDC42/TNF/SERPINE1/COL4A1/HRAS/PIM1/VEGFA/ICAM1/CCL2/AKT3/AGER/PIK3R3/COL4A2	3.80602940069588
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	45/669	388/9376	1.62544496324719	TUBB/CSNK2B/NDUFA3/PSMB3/NDUFA6/PSMA2/PSMC4/NDUFA7/PSMA6/TUBB4B/NDUFS3/ATF4/TNF/SLC39A1/MT-CO1/MT-CO3/TUBA1B/NDUFS1/HRAS/SLC39A7/NDUFA13/TUBB2A/SLC39A4/APOE/CSNK1E/MT-ND1/TUBB4A/PPP3R1/TUBA1A/CALML4/LRP1/AXIN2/CDK5R1/MT-ATP6/LRP6/AKT3/AGER/PIK3R3/TUBA1C/FADD/SDHA/MT-ND4/MT-ND5/PSMD9/MT-ND4L	3.4876898323041
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	16/669	93/9376	2.4111737949435	JUN/HLA-DRA/FOS/NFKBIA/HLA-DRB1/NFKBIB/HLA-DPA1/HLA-DPB1/MAML1/HLA-DMA/IFNGR2/NFKBIE/HLA-DQA1/HLA-DMB/PPP3R1/DLL1	3.79089911588269
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/669	93/9376	2.4111737949435	FN1/NFKBIA/GADD45B/MYC/CKS2/COL4A1/CDKN1A/TRAF4/GADD45G/CCNE1/PTEN/RXRB/AKT3/PIK3R3/COL4A2/E2F1	3.79089911588269
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	23/669	160/9376	2.01464872944694	HLA-E/HLA-C/HLA-A/HLA-B/HLA-F/HLA-DRA/HLA-DRB1/HLA-G/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/PDCD1/SIGLEC1/PTPRF/HLA-DMB/ICAM1/F11R/CLDN7/PVR/CD276/CLDN19/JAM2	3.58813602815598
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/669	70/9376	2.60277599829169	JUN/CDC42/EGLN2/CDKN1A/HRAS/EPAS1/EGLN1/VEGFA/PDGFB/AKT3/PIK3R3/SLC2A1/EGLN3	3.73082390639745
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/669	248/9376	1.75186846038864	JUN/HSP90AA1/HSP90AB1/CDC42/TUBB/FOS/NFKBIA/SKP1/TUBB4B/DYNLRB1/GSDMD/TNF/CD14/MYC/RHOB/TUBA1B/HRAS/DYNLL1/TUBB2A/TUBB4A/TUBA1A/ARPC1B/CYFIP1/SNX18/VPS11/AKT3/TUBA1C/FADD/AHNAK/ARHGEF26/MAP2K3	3.3261690402013
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	30/669	238/9376	1.76659004408938	RPS18/RPS9/RPL7A/RPS25/RPS17/PLCG2/RPL36A/JUN/RPS10/RPL17/FOS/NFKBIA/RPS4Y1/C1QA/NFKBIB/F13A1/TNF/C1QB/C1QC/IRF9/RPL26/FCGR2A/HBEGF/C2/CCL2/CGAS/NRP1/PIK3R3/IL6ST/PRKCG	3.32040073389083
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	17/669	109/9376	2.1858175285583	JUN/SPP1/CCL3/CCL4/FOS/NFKBIA/CCL5/TNF/CD14/CCL4L2/IRF7/IRF9/CCL3L1/AKT3/PIK3R3/FADD/MAP2K3	3.45164369398804
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	24/669	181/9376	1.85833560439016	LSP1/ATP6V0C/HLA-DRA/HSPD1/HLA-DRB1/TNF/HLA-DPA1/CD14/HLA-DPB1/PLK3/HLA-DMA/MRC1/IFNGR2/HLA-DQA1/IL10RB/FCGR2A/IL23A/HLA-DMB/CTSD/PPP3R1/CALML4/CEBPB/AKT3/FADD	3.23210136958357
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	15/669	94/9376	2.23642782177273	JUN/HSP90AA1/HSP90AB1/FOSB/FOS/NFKBIA/TNF/JUND/TRAF4/SRSF1/CCL2/CEBPB/CCL20/FADD/CXCL3	3.3394607123001
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/669	142/9376	1.97393629339565	JUN/HSP90AA1/HSP90AB1/SQSTM1/FOS/TNF/DUSP1/CTSL/HMOX1/VEGFA/GSTM3/NPPC/ICAM1/PDGFB/CCL2/CALML4/AKT3/PIK3R3/ARHGEF2/ACVR2B	3.2414864603907
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/669	173/9376	1.86325894052896	HLA-DRA/NFKBIA/HLA-DRB1/CCL5/DNAJB1/NFKBIB/TNF/HLA-DPA1/HLA-DPB1/IRF7/IRF9/HLA-DMA/IFNGR2/NXF1/HLA-DQA1/PABPN1/HLA-DMB/ICAM1/CCL2/AKT3/PIK3R3/FADD/KPNA2	3.17660964588357
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	22/669	163/9376	1.89158803084908	JUN/FOS/NFKBIA/ATF4/TNF/MYC/IRF7/CDKN1A/DDX3X/EGR3/HRAS/ATF6B/HSPG2/CCNE1/EGR2/PCNA/AKT3/PIK3R3/FADD/PRKCG/E2F1/MAP2K3	3.18289213539116
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	16/669	105/9376	2.13561107552139	PLCG2/LTB/CCL4/CSNK2B/NFKBIA/LTA/GADD45B/TNF/CD14/CCL4L2/NFKB2/GADD45G/ICAM1/TNFRSF13C/CXCL3/BTK	3.24358589633267
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	16/669	105/9376	2.13561107552139	PLCG2/JUN/LSP1/NFKBIA/TNF/IRF9/PLK3/EGR3/HRAS/NFKB2/IL23A/EGR2/PPP3R1/CALML4/AKT3/PIK3R3	3.24358589633267
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/669	69/9376	2.43738220575811	JUN/FOSB/FOS/ATF4/PRKACA/ATF6B/PPP3R1/CALML4/GNAS/ARC/PRKCG/SIRT1	3.32166918379201
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/669	78/9376	2.33582461385152	JUN/FOS/C1QA/TNF/CD14/C1QB/C1QC/ITGA5/IL23A/C2/CALML4/GNAI1/C4BPB	3.28372210699582
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/669	106/9376	2.11546380122402	HSP90AA1/HSP90AB1/NFKBIA/ATF4/CDKN1A/HRAS/FOLR2/CCNE1/PTEN/AR/FGFR1/PDGFB/AKT3/PIK3R3/ETV5/E2F1	3.2013486287008
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	21/669	157/9376	1.87461083659421	DUSP8/C1QA/SLC16A1/DUSP16/STAB1/ARG2/C1QB/C1QC/CD24/DUSP2/SGK1/LRP1/CEBPB/VPS11/AGER/SLC2A1/ALOX5/ODC1/SIRT1/DUSP7/ABCA1	3.06328354203514
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	21/669	157/9376	1.87461083659421	JUN/CDC42/NDUFA3/FOS/NDUFA6/NDUFA7/NDUFS3/ADIPOR2/ATF4/TNF/MT-CO1/MT-CO3/NDUFS1/NDUFA13/PRKAG1/MLXIP/SREBF1/CEBPA/AKT3/PIK3R3/SDHA	3.06328354203514
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/669	89/9376	2.20459851194975	TUBB/TUBB4B/PRKACA/TUBA1B/HRAS/TUBB2A/TUBB4A/TUBA1A/PDGFB/GNAS/GNAI1/HTR2B/TUBA1C/PRKCG	3.16492940790318
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/669	62/9376	2.48652297603549	HSPA1A/HSPA1B/HSPA8/PRKACA/HRAS/HSPA6/SOD2/PRKAG1/AKT3/PIK3R3/SIRT1	3.25509583174104
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	15/669	99/9376	2.1234769216832	HLA-DRA/HLA-DRB1/C1QA/HLA-DPA1/HLA-DPB1/C1QB/C1QC/HLA-DMA/HLA-DQA1/FCGR2A/HLA-DMB/ICAM1/C2/KRT18/KRT19	3.11488774070809
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/669	90/9376	2.18010297292808	JUN/CSNK2B/FOS/NFKBIA/NFKBIB/HRAS/IFNGR2/NFKBIE/PDCD1/PTEN/PPP3R1/AKT3/PIK3R3/MAP2K3	3.11810865225799
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/669	46/9376	2.74205498147787	PSME1/PSME2/PSMB8/PSMB3/PSMA2/PSMC4/PSMA6/PSMB9/PSMD9	3.28295081800071
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/669	100/9376	2.10224215246637	CCL3/CCL4/TNFRSF14/CCL5/LTA/TNF/CCL4L2/CSF1R/CCL3L1/IL10RB/CCL2/CCL20/CCL8/CXCL3/IL6ST	3.07157461969832
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	40/669	368/9376	1.52336387859882	TUBB/SQSTM1/NDUFA3/PSMB3/NDUFA6/CHCHD10/PSMA2/PSMC4/NDUFA7/PSMA6/TUBB4B/NDUFS3/HNRNPA2B1/ATF4/DAXX/TNF/MT-CO1/MT-CO3/FUS/TUBA1B/NDUFS1/NDUFA13/SRSF3/NXF1/TUBB2A/SMCR8/MT-ND1/TUBB4A/PPP3R1/TUBA1A/MT-ATP6/TUBA1C/SDHA/MT-ND4/MT-ND5/SRSF7/PSMD9/MAP2K3/GPX3/MT-ND4L	2.83908170251714
NA	NA	hsa04981	Folate transport and metabolism	7/669	31/9376	3.16466560586335	FOLR2/MTHFS/SHMT1/SLCO2B1/TYMS/SHMT2/ABCC1	3.34615793747285
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/669	142/9376	1.87523947872587	PLCG2/JUN/FOSB/SQSTM1/FOS/NFKBIA/TNF/JUND/IRF9/NFKB2/CSF1R/IFNGR2/FCGR2A/PPP3R1/SPI1/AKT3/PIK3R3/NCF4/BTK	2.9130005105342
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	26/669	217/9376	1.67921032147851	JUN/HSP90AA1/HSP90AB1/FOS/AHR/ATF4/MYC/KLF4/PRKACA/RPS6KA1/HRAS/ATF6B/VEGFA/RXRB/AR/GSTM3/GNAS/GNAI1/AKT3/BCL6/PIK3R3/KPNA2/PRKCG/KLF5/DLL1/E2F1	2.80591518398385
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	12/669	75/9376	2.24239162929746	GADD45B/CCND2/SESN2/SERPINE1/CDKN1A/GADD45G/CCNE1/PTEN/BBC3/CCNB1/PMAIP1/CCNG2	2.99425477635358
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/669	66/9376	2.33582461385152	JUN/HLA-DRA/HLA-DRB1/TNF/HLA-DPA1/HLA-DPB1/HLA-DMA/IFNGR2/HLA-DQA1/IL23A/HLA-DMB	3.01863771354695
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	19/669	144/9376	1.84919448596579	NFKBIA/C1QA/ADIPOR2/TNF/CD14/C1QB/C1QC/TRA2B/PRKAG1/SREBF1/C2/SCD/ACACA/AKT3/FADD/CXCL3/ACADVL/SIRT1/MAP2K3	2.84645903827653
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	13/669	85/9376	2.14346258682845	NME2/IMPDH2/AK6/ADSL/PNP/GMPR2/NME4/AK1/TYMS/TK1/NT5C3B/AMPD2/TYMP	2.93538193449717
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/669	49/9376	2.57417406424453	JUN/FOSB/ATF4/PRKACA/ATF6B/GNAS/GNAI1/CDK5R1/DLG4	3.06227528495253
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/669	76/9376	2.21288647628039	PLCG2/GADD45B/CDKN1A/HRAS/GADD45G/PTEN/PDGFB/CALML4/AKT3/PIK3R3/PRKCG/E2F1	2.94272650134289
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	24/669	200/9376	1.68179372197309	JUN/CDC42/TUBB/FOS/NFKBIA/NFKBIB/TUBB4B/TNF/TUBA1B/TUBB2A/FCGR2A/ARHGEF1/TUBB4A/CLDN7/TUBA1A/NCL/ARPC1B/CYFIP1/BAIAP2/ARHGEF2/TUBA1C/FADD/ABCF2/CLDN19	2.70150464198461
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/669	87/9376	2.0941875848324	JUN/FOS/GADD45B/MYC/CDKN1A/HRAS/GADD45G/BBC3/PMAIP1/AXIN2/RALGDS/AKT3/PIK3R3	2.84204763308305
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/669	107/9376	1.96471229202464	LDHA/ATF4/PRKACA/PRKAG1/PCK2/PPP3R1/CALML4/GNAS/ACACA/CRTC2/AKT3/SLC2A1/LDHC/PYGL/SIRT1	2.78187546874018
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/669	60/9376	2.33582461385152	PLCG2/CDC42/HRAS/VEGFA/PPP3R1/PLA2G4B/AKT3/PIK3R3/PRKCG/HSPB1	2.87723113753361
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	48/669	480/9376	1.40149476831091	TUBB/SQSTM1/CSNK2B/NDUFA3/PSMB3/NDUFA6/PSMA2/PSMC4/NDUFA7/PSMA6/TUBB4B/NDUFS3/ATF4/UBB/DAXX/TNF/MT-CO1/MT-CO3/FUS/TUBA1B/NDUFS1/HRAS/NDUFA13/TUBB2A/SMCR8/UBC/CSNK1E/MT-ND1/TUBB4A/PPP3R1/TUBA1A/CALML4/AXIN2/CDK5R1/MT-ATP6/LRP6/AGER/TUBA1C/FADD/SDHA/PRKCG/DLG4/MT-ND4/MT-ND5/PSMD9/MAP2K3/GPX3/MT-ND4L	2.50303859977691
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/669	52/9376	2.42566402207658	PRKACA/CGA/LDLR/SCARB1/GNAS/HSD17B1/PLA2G4B/ALOX5/CYP11A1	2.85747312301075
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	26/669	227/9376	1.60523629850589	JUN/NDUFA3/FOS/NDUFA6/NFKBIA/NDUFA7/NDUFS3/AHR/MT-CO1/MT-CO3/NDUFS1/HRAS/NDUFA13/PTEN/SOD2/HMOX1/VEGFA/MT-ND1/GSTM3/MT-ATP6/AKT3/PIK3R3/SDHA/MT-ND4/MT-ND5/MT-ND4L	2.55867724122091
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/669	71/9376	2.17132992273522	LDHA/MYC/HRAS/TIGAR/PTEN/FGFR1/SLC1A5/AKT3/PIK3R3/SLC2A1/LDHC	2.74608925214961
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	33/669	308/9376	1.50160153747598	POLR2A/TUBB/NDUFA3/PSMB3/NDUFA6/PSMA2/PSMC4/NDUFA7/PSMA6/TUBB4B/NDUFS3/POLR2J3/MT-CO1/MT-CO3/TUBA1B/NDUFS1/NDUFA13/TUBB2A/SOD2/BBC3/MT-ND1/AP2A2/TUBB4A/TUBA1A/MT-ATP6/TUBA1C/SDHA/DLG4/MT-ND4/MT-ND5/PSMD9/GPX3/MT-ND4L	2.48109210265162
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	21/669	174/9376	1.69145920313386	HSP90AA1/HSPH1/HSPA1A/DNAJA1/HSP90AB1/HSPA1B/HSPA8/CANX/DNAJB1/PPP1R15A/SKP1/ATF4/RNF5/HYOU1/ATF6B/TUSC3/HSPA6/RRBP1/BCAP29/DNAJB2/TXNDC5	2.55190495911688
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	35/669	333/9376	1.47304254927573	HLA-E/HLA-C/HLA-A/SPP1/HLA-B/FN1/ATP6V0C/HLA-F/CDC42/CHD4/HLA-G/PPP2CA/TNF/CCND2/COL4A1/PRKACA/MAML1/CDKN1A/IRF9/HRAS/CCNE1/HES4/PTEN/VEGFA/ITGA5/PPP2R3B/SCRIB/GNAS/AXIN2/HES1/AKT3/PIK3R3/FADD/COL4A2/E2F1	2.43629841485656
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/669	37/9376	2.65147658869632	GADD45B/MYC/CDKN1A/HRAS/GADD45G/RXRB/NCOA4	2.78989282970328
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	13/669	93/9376	1.9590787083916	JUN/EGR1/CDC42/ATF4/PRKACA/HRAS/HBEGF/CGA/CALML4/GNAS/MMP14/PLA2G4B/MAP2K3	2.57641591753706
Human Diseases	Infectious disease: viral	hsa05162	Measles	17/669	136/9376	1.75186846038864	JUN/HSPA1A/HSPA1B/CSNK2B/FOS/HSPA8/NFKBIA/NFKBIB/CCND2/IRF7/IRF9/CCNE1/HSPA6/BBC3/AKT3/PIK3R3/FADD	2.44815979092572
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	37/669	362/9376	1.43246702838408	HSP90AA1/SPP1/FN1/YWHAE/HSP90AB1/NR4A1/FLT1/ATF4/PPP2CA/CCND2/MYC/MCL1/COL4A1/GNG10/CDKN1A/CSH1/HRAS/ATF6B/CSF1R/CCNE1/PTEN/EFNA1/VEGFA/ITGA5/PPP2R3B/FGFR1/SGK1/PCK2/PDGFB/CRTC2/ANGPT1/AKT3/PIK3R3/GNG12/COL4A2/PGF/SGK3	2.32601727246072
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	19/669	158/9376	1.68534180999413	YWHAE/CDKN1C/SKP1/GADD45B/PPP2CA/CCND2/MAD1L1/MYC/CDKN1A/DDX11/GADD45G/CCNE1/CCNB1/MCM7/MAD2L1BP/PCNA/CDT1/MCM4/E2F1	2.40814062170416
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/669	30/9376	2.80298953662182	TNF/FOLR2/SHMT1/TYMS/SHMT2/ABCC1	2.74160807287351
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/669	170/9376	1.64881737448343	JUN/CDC42/RAPGEF6/ACTN4/PPP2CA/PRKACA/TUBA1B/HSPA4/ARHGAP17/PRKAG1/F11R/CLDN7/TUBA1A/SCRIB/ARPC1B/PCNA/ARHGEF2/TUBA1C/CLDN19/JAM2	2.36633306094574
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	23/669	205/9376	1.57240876444639	NDUFA3/NDUFA6/NDUFA7/NDUFS3/MT-CO1/MT-CO3/NDUFS1/NDUFA13/PTEN/MT-ND1/CTSD/MT-ATP6/PDK4/AKT3/AGER/PIK3R3/SLC2A1/NCF4/SDHA/PRKCG/MT-ND4/MT-ND5/MT-ND4L	2.29688516891729
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	31/669	298/9376	1.45793079924961	LTB/IL27RA/CCL3/CCL4/TNFRSF14/CCL5/LTA/TNF/CCL4L2/CSH1/CSF1R/IFNGR2/TNFRSF25/INHBA/CCL3L1/RELT/IL10RB/EBI3/IL23A/TNFRSF13C/CCL2/CCL20/GDF15/CCL8/IL11RA/IL1RN/CSF2RB/CXCL3/IL6ST/GDF11/ACVR2B	2.22678004987914
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/669	68/9376	2.06102171810428	CD14/MYC/HRAS/CSF1R/PIM1/JUP/CEBPA/SPI1/AKT3/PIK3R3	2.43396857913674
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	16/669	130/9376	1.72491663792112	JUN/FOS/NFKBIA/ATF4/COL4A1/PRKACA/GNG10/HRAS/ATF6B/VEGFA/GNAS/GNAI1/AKT3/PIK3R3/GNG12/COL4A2	2.30699803193379
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/669	109/9376	1.8000850235186	NFKBIA/TNF/RPS6KA1/PTEN/PTPRF/PRKAG1/MLXIP/SREBF1/PCK2/CRTC2/AKT3/PIK3R3/SLC2A1/PYGL	2.32886456775502
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/669	59/9376	2.13787337538953	GADD45B/MYC/CDKN1A/HRAS/GADD45G/PTEN/AXIN2/AKT3/PIK3R3	2.43022407340918
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/669	69/9376	2.03115183813176	PLCG2/TNF/INPP5D/HRAS/PLA2G4B/AKT3/PIK3R3/ALOX5/BTK/MAP2K3	2.38290502749493
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	8/669	50/9376	2.24239162929746	HLA-DRA/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DMA/HLA-DQA1/HLA-DMB/TNFRSF13C	2.44151972955538
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/669	110/9376	1.78372061421389	SMAD7/ID3/SKP1/PPP2CA/TNF/NOG/ID1/MYC/TGIF2/INHBA/BAMBI/RGMB/FBN1/ACVR2B	2.29179564421574
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/669	41/9376	2.39279594589668	MYC/CDKN1A/HRAS/VEGFA/HBEGF/TYMP/E2F1	2.47734610971707
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/669	100/9376	1.82194319880419	HLA-DRA/HLA-DRB1/TNF/HLA-DPA1/CD14/HLA-DPB1/HLA-DMA/CSF1R/HLA-DQA1/ITGA5/HLA-DMB/CD24/IL11RA	2.29047660954667
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/669	90/9376	1.86865969108122	ADIPOR2/ATF4/EHMT2/SESN2/PRKACA/HRAS/ATF6B/SOD2/PRKAG1/AKT3/PIK3R3/SIRT1	2.29520250415736
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/669	70/9376	2.0021353833013	NFKBIA/NFKBIB/ADIPOR2/TNF/NFKBIE/PRKAG1/RXRB/PCK2/AKT3/SLC2A1	2.33269692673975
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/669	133/9376	1.68600874383268	HLA-E/HLA-C/HLA-A/PLCG2/HLA-B/HLA-G/TNF/KLRK1/HRAS/IFNGR2/MICB/ICAM1/NCR3/PPP3R1/PIK3R3/PRKCG	2.20858144936404
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/669	91/9376	1.8481249692012	PLCG2/JUN/FOS/NFKBIA/NFKBIB/INPP5D/HRAS/NFKBIE/PPP3R1/AKT3/PIK3R3/BTK	2.25348159929796
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/669	71/9376	1.97393629339565	PLCG2/JUN/ATP6V0C/CDC42/NFKBIA/CCL5/HBEGF/F11R/CXCL3/JAM2	2.28331568728891
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	22/669	201/9376	1.53397437327563	FLT1/GADD45B/CCND2/CD14/MYC/FUS/CDKN1A/CSF1R/GADD45G/RXRB/KMT2A/JUP/CEBPB/REL/CEBPA/SPI1/MLLT1/BCL6/CDK9/TAF15/ETV5/MYCN	2.12119127353345
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/669	52/9376	2.1561457974014	PLTP/APOC2/APOE/LDLR/SCARB1/ANGPTL4/LRP1/ABCA1	2.31727496184153
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	19/669	168/9376	1.58502384511353	IL27RA/CCND2/MYC/MCL1/CDKN1A/IRF9/CSH1/HRAS/IFNGR2/IL10RB/PIM1/IL23A/PDGFB/IL11RA/SOCS7/AKT3/PIK3R3/CSF2RB/IL6ST	2.12085012119154
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	13/669	103/9376	1.7688768920429	DDX39B/PPP2CA/FUS/RBM8A/NXF1/CPSF1/EIF4A3/PABPN1/PABPC4/PPP2R3B/NUDT21/DDX19B/PCF11	2.1748520388704
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/669	103/9376	1.7688768920429	FN1/ARG2/ACTN4/TNF/CD14/COL4A1/PRKACA/GNAS/PIK3R3/CXCL3/COL4A2/PRKCG/HSPB1	2.1748520388704
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/669	238/9376	1.47215837007449	PLCG2/CDC42/RASA3/FLT1/SYNGAP1/PRKACA/GNG10/HRAS/CSF1R/EFNA1/VEGFA/FOXO4/FGFR1/RGL2/PDGFB/CALML4/REL/RALGDS/ANGPT1/PLA2G4B/AKT3/PIK3R3/GNG12/PRKCG/PGF	2.04510221675306
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/669	73/9376	1.91985584700125	GADD45B/CDKN1A/HRAS/GADD45G/PTEN/FGFR1/PDGFB/AKT3/PIK3R3/E2F1	2.18692615020743
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/669	73/9376	1.91985584700125	PLCG2/GADD45B/CDKN1A/HRAS/GADD45G/RXRB/AKT3/PIK3R3/PRKCG/E2F1	2.18692615020743
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	17/669	148/9376	1.60982507170848	JUN/FOS/GADD45B/MYC/CDKN1A/HRAS/NFKB2/GADD45G/PTEN/FGFR1/AXIN2/HES1/LRP6/AKT3/PIK3R3/DLL1/E2F1	2.07274924273884
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/669	105/9376	1.73518399886113	JUN/SQSTM1/CSNK2B/GABARAP/ATF4/UBB/HRAS/UBC/RABGEF1/ATG9A/PGAM5/TFEB/E2F1	2.09986720041504
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/669	138/9376	1.62492147050541	JUN/FN1/CDC42/FOS/NFKBIA/TNF/RPS6KA1/FCGR2A/ITGA5/ARHGEF1/CCL2/ARPC1B/BAIAP2/AKT3/PIK3R3/MAP2K3	2.04993662660465
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/669	75/9376	1.86865969108122	CANX/ATF4/PRKACA/ATF6B/CGA/ATP1B2/GNAS/ATP1A1/PRKCG/GPX3	2.09353344606527
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/669	36/9376	2.33582461385152	POLD4/SSBP1/MCM7/PCNA/MCM4/POLD1	2.22582839597633
Genetic Information Processing	Transcription	hsa03040	Spliceosome	25/669	243/9376	1.44186704558736	HSPA1A/DDX39B/HSPA1B/HSPA8/CWC25/HNRNPU/PRPF8/LSM2/PUF60/PRPF31/SRSF2/DHX16/FUS/RBM8A/SRSF3/PRPF38B/EIF4A3/HSPA6/TRA2B/SRSF1/SRSF6/RBM25/SRSF7/RBMX/ISY1	1.93442744840651
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/669	98/9376	1.71611604282969	PLCG2/CDC42/INPP5D/MARCKS/MARCKSL1/FCGR2A/ARPC1B/PLA2G4B/AKT3/PIK3R3/PRKCG/PLPP2	1.97530281092174
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/669	98/9376	1.71611604282969	NR4A1/ATF4/PRKACA/ATF6B/LDLR/SCARB1/ATP1B2/CALML4/GNAS/ATP1A1/PRKCG/CYP11A1	1.97530281092174
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	24/669	235/9376	1.43131380593455	NDUFA3/NDUFA6/NDUFA7/NDUFS3/SMARCB1/MT-CO1/MT-CO3/PRKACA/NDUFS1/RPS6KA1/HRAS/NDUFA13/COX16/PRKAG1/MT-ND1/FGFR1/PNPLA2/GNAS/MT-ATP6/SDHA/MT-ND4/MT-ND5/MAP2K3/MT-ND4L	1.85607217968368
NA	NA	hsa04518	Integrin signaling	17/669	154/9376	1.54710461436919	SPP1/FN1/CDC42/FLT1/ACTN4/CCND2/COL4A1/VEGFA/ITGA5/ICAM1/PDGFB/AKT3/FBN1/ICAM4/PIK3R3/COL4A2/PGF	1.8975035803783
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	22/669	212/9376	1.45438136334151	CDC42/FLT1/RAPGEF6/ID1/HRAS/CSF1R/EFNA1/VEGFA/FGFR1/PDGFB/ADORA2A/CALML4/GNAS/GNAI1/RALGDS/ANGPT1/AKT3/PIK3R3/PRKCG/CTNND1/PGF/MAP2K3	1.85485653867849
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/669	122/9376	1.60827268494695	ADIPOR2/PPP2CA/EEF2/PRKAG1/PPP2R3B/EEF2K/SREBF1/PCK2/SCD/ACACA/CRTC2/AKT3/PIK3R3/SIRT1	1.87446746632385
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/669	122/9376	1.60827268494695	JUN/CDC42/FOS/NFKBIA/NFKBIB/PPP2CA/TNF/HRAS/NFKBIE/PDCD1/PPP2R3B/PPP3R1/AKT3/PIK3R3	1.87446746632385
NA	NA	hsa03272	Virion - Hepatitis viruses	7/669	48/9376	2.04384653712008	CHMP4A/HSPG2/CHMP1B/LDLR/SCARB1/CLDN7/CLDN19	2.0096824023151
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/669	156/9376	1.52726993982599	YWHAE/NFKBIA/PPP2CA/TNF/MYC/IRF7/CDKN1A/IRF9/HRAS/LDLR/SCARB1/CLDN7/AKT3/PIK3R3/FADD/CLDN19/E2F1	1.84074774021384
NA	NA	hsa04517	IgSF CAM signaling	29/669	299/9376	1.35930930705741	PLCG2/CDC42/TUBB/TUBB4B/RAPGEF6/ACTN4/INPP5D/TUBA1B/DYNLL1/TUBB2A/PTPRF/PPFIA1/ITGA5/FGFR1/TUBB4A/ICAM1/F11R/TUBA1A/NRP2/ARPC1B/NRP1/BAIAP2/AKT3/PIK3R3/TUBA1C/MTSS1/PVR/PRKCG/JAM2	1.75023884347404
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/669	39/9376	2.1561457974014	MTHFS/SHMT1/AHCY/MAT2A/TYMS/SHMT2	2.00542144065073
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/669	59/9376	1.90033188923513	PRKACA/ABHD5/CGA/PNPLA2/GNAS/GNAI1/AKT3/PIK3R3	1.9228925455156
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	20/669	193/9376	1.45232618477815	PLCG2/CDC42/CCL3/CCL4/NFKBIA/CCL5/NFKBIB/CCL4L2/PRKACA/GNG10/HRAS/CCL3L1/CCL2/GNAI1/CCL20/CCL8/AKT3/PIK3R3/CXCL3/GNG12	1.75995886222593
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/669	50/9376	1.96209267563528	TNF/KLRK1/ICAM1/CCL2/LRP1/HBA1/HBA2	1.890682610726
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/669	149/9376	1.50496082503185	NDUFA3/NDUFA6/NDUFA7/NDUFS3/PRKACA/GNG10/NDUFS1/NDUFA13/MT-ND1/NAPEPLD/GNAI1/GNG12/PRKCG/MT-ND4/MT-ND5/MT-ND4L	1.72220555421155
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/669	138/9376	1.52336387859882	ATP6V0C/NDUFA3/NDUFA6/NDUFA7/NDUFS3/MT-CO1/MT-CO3/NDUFS1/NDUFA13/MT-ND1/MT-ATP6/SDHA/MT-ND4/MT-ND5/MT-ND4L	1.71679616466675
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/669	116/9376	1.5706406886243	PLCG2/CDC42/ACTN4/ICAM1/F11R/CLDN7/GNAI1/PIK3R3/NCF4/PRKCG/CTNND1/CLDN19/JAM2	1.71415725535197
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	10/669	83/9376	1.6885479136276	CCL4/NFKBIA/CCL5/NFKBIB/GSDMD/CCL4L2/IRF7/POLR3E/CGAS/FADD	1.74646412553762
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	19/669	187/9376	1.42397864159932	JUN/HSP90AA1/YWHAE/GPSM3/HSP90AB1/CTSB/GABARAP/NFKBIA/CCL5/NFKBIB/GSDMD/TNF/IRF7/IRF9/ATG16L1/CCL2/FADD/P2RX7/CXCL3	1.62328614325514
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/669	23/9376	2.43738220575811	POLD4/SSBP1/PCNA/POLD1	1.91304479699612
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/669	23/9376	2.43738220575811	ATP1B2/PCK2/ATP1A1/CA2	1.91304479699612
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/669	154/9376	1.45609846058277	JUN/FOS/PRKACA/CDKN1A/HRAS/EEF2/PRKAG1/EEF2K/PPP3R1/CALML4/GNAS/GNAI1/KCNJ2/PLA2G4B/CACNA2D4/PRKCG	1.58187015651237
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	24/669	250/9376	1.34543497757848	HLA-E/HLA-C/HLA-A/ACAP1/HLA-B/HSPA1A/HLA-F/CDC42/HSPA1B/VPS28/CHMP4A/HSPA8/HLA-G/DAB2/HRAS/FOLR2/RUFY1/HSPA6/CHMP1B/AP2A2/WASHC1/LDLR/ARPC1B/ARFGAP1	1.53447743942016
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/669	120/9376	1.51828599900349	PLCG2/JUN/YWHAE/CDC42/NFKBIA/NFKBIB/ATF4/RPS6KA1/HRAS/NFKBIE/CALML4/AKT3/PIK3R3	1.58384563432546
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	16/669	155/9376	1.4467042769661	NR4A1/AHR/ATF4/PRKACA/CDKN1A/ATF6B/CCNE1/RASD1/LDLR/SCARB1/KMT2A/GNAS/GNAI1/AXIN2/CYP11A1/E2F1	1.55439493902313
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/669	15/9376	2.80298953662182	HEXB/ST6GALNAC6/B3GALT4	1.93705582978978
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/669	54/9376	1.81675247744007	LDHA/ADI1/AMD1/AHCY/MAT2A/LDHC/KYAT1	1.66838860875303
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/669	65/9376	1.72491663792112	NR4A1/ATF4/PRKACA/ATF6B/LDLR/SCARB1/GNAS/CYP11A1	1.62558995667507
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/669	76/9376	1.65966485721029	PLTP/UBC/RXRB/HMGCS1/PLIN2/PCK2/SCD/ANGPTL4/OLR1	1.60049047893625
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/669	76/9376	1.65966485721029	PRKACA/ATP1B2/CALML4/GNAS/GNAI1/KCNJ2/ATP1A1/PRKCG/CA2	1.60049047893625
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	20/669	204/9376	1.37401447873619	PLCG2/FN1/CDC42/TNF/TIMP3/MYC/CTSL/PRKACA/CDKN1A/HRAS/HSPG2/VEGFA/ITGA5/ARHGEF1/HBEGF/FGFR1/AKT3/PIK3R3/TFAP4/PRKCG	1.49704860305902
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/669	34/9376	2.06102171810428	SKP1/PRKAG1/CSNK1E/PER1/BHLHE41	1.71794092444737
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/669	99/9376	1.55721640923435	JUN/FOS/PRKACA/CDKN1A/HRAS/HBEGF/GNAS/AKT3/PIK3R3/DLL1/E2F1	1.54490628916975
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/669	99/9376	1.55721640923435	JUN/FOS/CHKB/HRAS/PDGFB/RALGDS/PLA2G4B/AKT3/PIK3R3/PRKCG/PLPP2	1.54490628916975
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/669	122/9376	1.49339606459359	PLCG2/MYC/PRKACA/HRAS/DIO2/RXRB/ATP1B2/ATP1A1/AKT3/PIK3R3/SLC2A1/PRKCG/MED16	1.52046096098097
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/669	122/9376	1.49339606459359	PLCG2/FOS/ATF4/PRKACA/CSH1/HRAS/ATF6B/GNAS/GNAI1/AKT3/PIK3R3/PRKCG/MAP2K3	1.52046096098097
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	17/669	169/9376	1.40978763676246	CTSB/SQSTM1/GABARAP/PPP2CA/UBB/CTSL/PRKACA/HRAS/ATG16L1/PTEN/SMCR8/UBC/CTSD/VPS11/ATG9A/AKT3/PIK3R3	1.49007304061044
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/669	88/9376	1.5926076912624	SERPINE2/C1QA/F13A1/SERPINE1/C1QB/C1QC/VSIG4/C2/TFPI/C4BPB	1.54814609377107
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/669	77/9376	1.63811076815561	CDC42/GADD45B/CDKN1A/GADD45G/VEGFA/RALGDS/AKT3/PIK3R3/E2F1	1.55843156873864
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/669	77/9376	1.63811076815561	NFKBIA/GADD45B/MYC/CDKN1A/HRAS/GADD45G/AKT3/PIK3R3/E2F1	1.55843156873864
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/669	125/9376	1.45755455904335	PPP2CA/TNF/HRAS/PTEN/SGPP1/PPP2R3B/CTSD/GNAI1/AKT3/PIK3R3/S1PR2/PRKCG/ABCC1	1.4274732476863
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/669	37/9376	1.8939118490688	TNF/ICAM1/HBA1/HBA2/PRKCG	1.51011420638579
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/669	250/9376	1.28937518684604	ATP6V0C/CTSB/NEU1/CLN8/LGMN/IDS/BORCS5/CTSL/HEXB/PSAP/AP2A2/CD68/CTSD/SLC2A6/VPS11/PPT2/CLN3/CTSZ/CTSO/MAN2B1/TFEB/CLN6/GLA	1.28545087951426
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/669	38/9376	1.84407206356699	SGK1/ATP1B2/ATP1A1/PIK3R3/PRKCG	1.44513631608925
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/669	71/9376	1.57914903471652	FOS/CCND2/HRAS/GALT/CGA/SOCS7/AKT3/PIK3R3	1.35776855756751
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/669	18/9376	2.33582461385152	NEU1/HEXB/MAN2B1	1.5723839367238
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	17/669	178/9376	1.33850623939806	JUN/CSNK2B/NOTUM/SKP1/CCND2/MYC/PRKACA/CACYBP/CSNK1E/SFRP1/BAMBI/PPP3R1/AXIN2/LRP6/PRKCG/SERPINF1/SIRT1	1.26384670775021
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	19/669	203/9376	1.31174387181809	JUN/SPP1/FN1/CDC42/FLT1/ACTN4/CCND2/ZYX/COL4A1/HRAS/PTEN/VEGFA/ITGA5/PDGFB/AKT3/PIK3R3/COL4A2/PRKCG/PGF	1.24467128987607
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/669	143/9376	1.37209278016453	HLA-DRA/HLA-DRB1/C1QA/ACTN4/TNF/HLA-DPA1/HLA-DPB1/C1QB/C1QC/HLA-DMA/HLA-DQA1/FCGR2A/HLA-DMB/C2	1.24283154889605
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/669	61/9376	1.60827268494695	HMOX2/FTL/SLC39A4/HMOX1/ATP1B2/ATP1A1/SLC30A1	1.32110162647922
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/669	50/9376	1.68179372197309	AOC1/ARG2/SAT1/AMD1/GATM/ODC1	1.33984549189662
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	10/669	97/9376	1.44483996733084	FOS/PRKACA/GNG10/RASD1/CALML4/GNAS/PER1/GNAI1/GNG12/PRKCG	1.22068471019208
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	13/669	133/9376	1.36988210436405	FOS/ATF4/PPP2CA/PRKACA/GNG10/ATF6B/PPP2R3B/CALML4/GNAS/GNAI1/AKT3/GNG12/PRKCG	1.19082265567948
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	16/669	170/9376	1.31905389958674	PLCG2/SMARCB1/GADD45B/MYC/CDKN1A/HRAS/GADD45G/PTEN/HMOX1/GSTM3/AXIN2/LRP6/AKT3/PIK3R3/PRKCG/E2F1	1.16363682679872
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/669	86/9376	1.46668057148816	PLCG2/JUN/MYC/CDKN1A/HRAS/HBEGF/AKT3/PIK3R3/PRKCG	1.20510673748708
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/669	63/9376	1.55721640923435	POLR2A/POLD4/POLR2J3/GTF2H1/GTF2H4/PCNA/POLD1	1.23002459478599
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/669	41/9376	1.70913996135477	POLD4/RAD50/SSBP1/TOP3A/POLD1	1.26133704630806
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/669	20/9376	2.10224215246637	CYP51A1/FDFT1/SQLE	1.36776451286752
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/669	53/9376	1.58659785091801	PRKACA/AP2A2/ATP1B2/GNAS/ATP1A1/PRKCG	1.18703899240289
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/669	42/9376	1.66844615275109	FTL/SAT1/HMOX1/SLC3A2/NCOA4	1.203432122911
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/669	65/9376	1.50930205818098	AGPAT5/DGAT1/ABHD16A/AGPAT1/PNPLA2/PLPP2/GLA	1.14208485139368
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/669	89/9376	1.41724190053912	GABARAP/PRKACA/GNG10/SLC38A2/GLUL/GNAI1/NSF/GNG12/PRKCG	1.09625003528211
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/669	138/9376	1.32024869478564	FLOT1/MKNK2/PRKACA/HRAS/PTPRF/PRKAG1/SREBF1/PCK2/CALML4/ACACA/AKT3/PIK3R3/PYGL	1.05051524079095
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/669	43/9376	1.62964507943129	DGAT1/AGPAT1/SCARB1/PLPP2/ABCA1	1.14705392019683
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/669	78/9376	1.43743053160094	PLCG2/INPP5D/ITPK1/PIP4K2B/PTEN/ISYNA1/TPI1/INPP5E	1.07529109135923
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/669	78/9376	1.43743053160094	HSPD1/LSM2/BTG2/TOB2/CNOT3/PARN/PABPC4/EXOSC4	1.07529109135923
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/669	32/9376	1.75186846038864	LDHA/BCKDHA/ACACA/LDHC	1.18090474165531
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/669	32/9376	1.75186846038864	GABARAP/PPP2CA/ATG16L1/ATG9A	1.18090474165531
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	22/669	253/9376	1.21869110287905	PLCG2/JUN/CDC42/SQSTM1/NFKBIA/CCL5/NFKBIB/SKP1/ACTN4/UBB/TNF/CD14/ATG16L1/UBC/ITGA5/FOXO4/TIFA/ARPC1B/CGAS/AKT3/PIK3R3/ARHGEF2	0.977432921759242
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/669	55/9376	1.5289033836119	NEU1/HEXB/PSAP/SGPP1/PLPP2/GLA	1.09041259939951
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/669	115/9376	1.34056021316696	FOS/ATF4/PRKACA/GNG10/HRAS/GNAI1/KCNJ2/AKT3/PIK3R3/GNG12/PRKCG	1.01854052228605
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/669	115/9376	1.34056021316696	DUSP1/PRKACA/GNG10/HRAS/GNAS/GNAI1/PLA2G4B/HTR2B/ALOX5/GNG12/PRKCG	1.01854052228605
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/669	67/9376	1.46424826539946	ATF4/PRKACA/RPS6KA1/HRAS/PPP3R1/CALML4/PRKCG	1.05706234075123
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/669	116/9376	1.32900365960517	PRKACA/GNG10/SLC38A2/GLUL/PPP3R1/GNAS/GNAI1/PLA2G4B/GNG12/PRKCG/DLG4	0.988299680328028
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/669	80/9376	1.40149476831091	PLCG2/HRAS/PTEN/VEGFA/PDGFB/AKT3/PIK3R3/PRKCG	0.999634534619863
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/669	69/9376	1.42180628669223	CTSB/PRKACA/PPP3R1/CALML4/GNAS/GNAI1/KCNJ2	0.974758793049303
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/669	23/9376	1.82803665431858	ARG2/GLUL/ACY1	1.10205288956583
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	13/669	144/9376	1.26523833250291	ID3/ID1/MYC/KLF4/HRAS/DUSP9/INHBA/FGFR1/AXIN2/AKT3/PIK3R3/IL6ST/ACVR2B	0.889066122457972
Genetic Information Processing	Translation	hsa03010	Ribosome	19/669	222/9376	1.19947750441024	RPS18/RPS9/RPL7A/RPS25/RPS17/RPL36A/RPS10/RPL17/RPS4Y1/MRPS24/MRPS12/MRPL38/MRPL23/MRPS18B/MRPL45/RPL26/MRPL18/MRPL46/MRPL32	0.833737593302225
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/669	83/9376	1.35083833090208	CSNK2B/SKP1/PHF1/RYBP/RING1/EPOP/CBX8/BCOR	0.889882238631505
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/669	59/9376	1.42524891692635	NME2/NME4/TYMS/TK1/NT5C3B/TYMP	0.908229489728434
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/669	59/9376	1.42524891692635	HPGDS/GSTM3/CHAC1/TXNDC12/ODC1/GPX3	0.908229489728434
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/669	60/9376	1.40149476831091	PPP2CA/HRAS/GNAS/GNAI1/PLA2G4B/PRKCG	0.864779131154264
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/669	48/9376	1.4598903836572	ATP1B2/ATP1A1/AKT3/PIK3R3/SLC37A4	0.88541138775028
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/669	73/9376	1.34389909290087	CHMP4A/SMARCB1/SUPT4H1/NELFE/MLLT1/CDK9/MAP1A	0.817608456530815
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/669	98/9376	1.28708703212227	PLCG2/INPP5D/ITPK1/PIP4K2B/PTEN/CALML4/PIK3R3/PRKCG/INPP5E	0.791888168416805
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/669	86/9376	1.30371606354503	ATF4/PRKACA/ATF6B/ATP1B2/GNAS/ATP1A1/SLC2A1/PRKCG	0.784284362415242
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/669	150/9376	1.21462879920279	GADD45B/MYC/CDKN1A/HRAS/GADD45G/CCNE1/RXRB/JUP/AXIN2/LRP6/AKT3/PIK3R3/E2F1	0.734499196524208
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/669	99/9376	1.27408615300992	PLCG2/PRKACA/CALML4/GNAS/PLA2G4B/HTR2B/PIK3R3/PRKCG/MAP2K3	0.759915563400584
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/669	138/9376	1.21869110287905	YWHAE/SKP1/PPP2CA/MAD1L1/PRKACA/RPS6KA1/CCNE1/REC8/AR/PPP3R1/CALML4/CCNB1	0.717374778853049
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/669	38/9376	1.47525765085359	NAPRT/SIRT2/PNP/SIRT1	0.813688925854707
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/669	38/9376	1.47525765085359	TAP1/TAP2/TNFRSF13C/BTK	0.813688925854707
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/669	75/9376	1.30806178375685	ARG2/GLUL/SHMT1/TPI1/MAT2A/SHMT2/ACY1	0.742451450632806
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/669	75/9376	1.30806178375685	CDKN1A/BBC3/GSTM3/PMAIP1/AKT3/PIK3R3/FADD	0.742451450632806
Organismal Systems	Immune system	hsa04611	Platelet activation	11/669	126/9376	1.22352717868413	PLCG2/PRKACA/PTGIR/FCGR2A/ARHGEF1/GNAS/GNAI1/PLA2G4B/AKT3/PIK3R3/BTK	0.70017913944967
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/669	63/9376	1.33475692220087	EHMT2/KMT2A/KMT5A/KMT5C/PLOD2/COLGALT1	0.738957505123934
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	13/669	154/9376	1.1830799992235	NME2/NAPRT/AK6/ADSL/SHMT1/ALAS1/RDH13/PDXP/NME4/MAT2A/AK1/UGDH/SHMT2	0.634969884914584
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/669	154/9376	1.1830799992235	ATF4/PPP2CA/PRKACA/ATF6B/TPM1/PPP2R3B/ATP1B2/CALML4/GNAS/GNAI1/CACNA2D4/ATP1A1/AKT3	0.634969884914584
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/669	168/9376	1.16791230692576	HSP90AA1/HSP90AB1/SQSTM1/CHMP4A/FTL/TNF/IRF9/IFNGR2/GLUL/CHMP1B/PLA2G4B/FADD/PGAM5/PYGL	0.608721917008255
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/669	90/9376	1.24577312738748	PRKACA/LDLR/SCARB1/ATP1B2/GNAS/ATP1A1/SLC2A1/CA2	0.649390207956114
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/669	16/9376	1.75186846038864	HEXB/GLA	0.834311748277168
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/669	65/9376	1.29368747844084	SPP1/HRAS/CGA/AKT3/PIK3R3/PRKCG	0.658579746112278
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/669	28/9376	1.50160153747598	ATP6V0C/SLC12A7/CA2	0.736788684934159
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/669	157/9376	1.16047337503451	YWHAE/SMAD7/PPP2CA/CCND2/ID1/SERPINE1/MYC/BBC3/CSNK1E/DLG5/SCRIB/AXIN2/DLG4	0.562050489326521
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	15/669	184/9376	1.14252290894911	PLCG2/CDC42/HRAS/EFNA1/EPHB6/RND1/EFNB2/SEMA7A/PPP3R1/GNAI1/NRP1/PIK3R3/EPHA1/EFNB1/PLXNB2	0.541194041504862
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/669	41/9376	1.36731196908382	SHMT1/ALAS1/GATM/SHMT2	0.653332514603552
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/669	93/9376	1.20558689747175	CDC42/CSNK2B/ACTN4/SNAI1/PTPRF/FGFR1/BAIAP2/CTNND1	0.552277253627667
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/669	17/9376	1.64881737448343	GLUL/CA2	0.742158444085185
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/669	17/9376	1.64881737448343	NRP2/PCDH9	0.742158444085185
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/669	18/9376	1.55721640923435	HSD17B8/ACACA	0.655893088114926
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/669	83/9376	1.18198353953932	ECH1/DHRS4/SOD2/PHYH/DECR2/PEX6/PEX5	0.461591295178449
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/669	31/9376	1.35628525965572	GLUL/SHMT1/SHMT2	0.550748691332432
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/669	57/9376	1.22938137571133	HSD17B8/SCD/ACACA/PPT2/ACADVL	0.481476782771615
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/669	44/9376	1.27408615300992	MGAT4B/HEXB/TUSC3/ALG9	0.505115264854387
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/669	44/9376	1.27408615300992	TAF9/GTF2H1/GTF2H4/TAF15	0.505115264854387
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/669	44/9376	1.27408615300992	POLD4/PCNA/MUTYH/POLD1	0.505115264854387
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/669	44/9376	1.27408615300992	PRKACA/DYNLL1/GNAS/NSF	0.505115264854387
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/669	110/9376	1.14667753770893	HSP90AA1/HSP90AB1/MAD1L1/PRKACA/RPS6KA1/CCNB1/GNAI1/AKT3/PIK3R3	0.428921909069333
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/669	19/9376	1.47525765085359	IDS/HEXB	0.574780502330505
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/669	233/9376	1.08269982101272	FN1/ZYX/COL4A1/LMNA/FBLN1/HSPG2/TPM1/ITGA5/CSRP2/DMD/BGN/ATP1B2/JUP/ATP1A1/FBN1/MYOM2/COL4A2/AMPD2	0.35432565211737
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/669	45/9376	1.24577312738748	TAP1/TAP2/ABCC1/ABCA1	0.458079633076508
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/669	32/9376	1.31390134529148	BBC3/PMAIP1/FADD	0.493021860333229
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/669	72/9376	1.16791230692576	NFKBIA/NFKBIB/TNF/IRF7/DDX3X/FADD	0.396440806152657
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/669	140/9376	1.10117446081572	SPP1/EGR1/SERPINE1/PRKACA/GNG10/HRAS/PRKAG1/CALML4/GNAI1/AKT3/GNG12	0.334316167217081
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/669	46/9376	1.21869110287905	HMOX2/FTL/HMOX1/ALAS1	0.412129434902906
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/669	20/9376	1.40149476831091	NPL/UGDH	0.498212026249274
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	10/669	128/9376	1.0949177877429	NME2/IMPDH2/AK6/ADSL/PNP/GMPR2/NME4/AK1/PDE6G/AMPD2	0.299704391537107
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/669	47/9376	1.19276150494546	LDHA/PCK2/ACACA/LDHC	0.367211366408507
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/669	34/9376	1.23661303086257	POLR2A/POLR2J3/POLR3E	0.383109225796626
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	24/669	323/9376	1.04135834177901	PLCG2/CCND2/TIMP3/MARCKS/MYC/MCL1/CDKN1A/HRAS/FSCN1/CCNE1/PIM1/PTEN/EFNA1/TPM1/HMOX1/VEGFA/ITGA5/PDGFB/PIK3R3/PRKCG/FOXP1/E2F1/SIRT1/ABCC1	0.209668188836055
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/669	158/9376	1.06442640631208	TNF/SESN2/RPS6KA1/HRAS/PTEN/SGK1/CASTOR1/LRP6/AKT3/PIK3R3/PRKCG/SLC3A2	0.226380243971803
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/669	117/9376	1.0780728987007	CHD4/INO80D/SMARCB1/INO80B/SRCAP/TFPT/CHD3/SMARCA1/MTA1	0.235545937280175
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/669	104/9376	1.0780728987007	AGPAT5/CHKB/CRLS1/AGPAT1/MBOAT7/LPCAT1/PLA2G4B/PLPP2	0.221919102449604
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/669	63/9376	1.11229743516739	HPGDS/PRXL2B/LTC4S/PLA2G4B/ALOX5	0.247890415461874
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/669	22/9376	1.27408615300992	AOC1/HNMT	0.356750160986384
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/669	105/9376	1.06780553776069	TNF/PRKACA/LMNA/TPM1/ITGA5/DMD/GNAS/CACNA2D4	0.193669373885654
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/669	36/9376	1.16791230692576	C1GALT1C1/GALNT4/ST6GALNAC1	0.279785217994787
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/669	78/9376	1.0780728987007	FN1/CDC42/ITGA5/ARPC1B/PIK3R3/ARHGEF26	0.191918685104596
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/669	134/9376	1.04589161814247	PRKACA/PTGIR/ADM/ARHGEF1/NPPC/ADORA2A/CALML4/GNAS/PLA2G4B/PRKCG	0.148308899794746
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/669	23/9376	1.21869110287905	HMGCS1/FNTB	0.291060982135549
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/669	37/9376	1.13634710944128	ADSL/GLUL/RIMKLB	0.230335583068289
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/669	51/9376	1.09921158298895	LPCAT1/PLA2G4B/PLA2G7/PLPP2	0.196918932058716
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/669	51/9376	1.09921158298895	PLCG2/ATP6V0C/PRKACA/GNAS	0.196918932058716
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/669	93/9376	1.05488853528778	PRKACA/ATP1B2/CALML4/GNAS/ATP1A1/PRH1/PRKCG	0.147449520845789
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	11/669	149/9376	1.0346605672094	PLCG2/AGPAT5/HRAS/AGPAT1/PDGFB/GNAS/RALGDS/PLA2G4B/AKT3/PIK3R3/PLPP2	0.118212380844361
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/669	66/9376	1.0617384608416	HSD17B8/HSD17B1/DHRS11/CYP11A1/SRD5A3	0.139513858586162
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/669	38/9376	1.10644323814019	HEXB/GALT/UGDH	0.182241535620165
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/669	82/9376	1.02548397681286	NME2/IMPDH2/GSTM3/NME4/TK1/TYMP	0.0642446870972077
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/669	26/9376	1.0780728987007	MAFA/HES1	0.110495755989961
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/669	26/9376	1.0780728987007	SCARB1/ABCC1	0.110495755989961
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/669	99/9376	0.990955896785493	TNF/LMNA/PRKAG1/TPM1/ITGA5/DMD/CACNA2D4	-0.0250751623685864
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/669	56/9376	1.00106769165065	MGAT4B/TUSC3/ALG9/SRD5A3	0.00222124431214751
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/669	27/9376	1.0381442728229	HMGCS1/BDH1	0.0550165137732388
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	16/669	232/9376	0.966548116076491	FN1/CDC42/ACTN4/HRAS/PIP4K2B/ITGA5/ARHGEF1/FGFR1/PDGFB/ARPC1B/CYFIP1/BAIAP2/AKT3/PIK3R3/GNG12/SPATA13	-0.14300818333429
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/669	87/9376	0.966548116076491	MT-CO1/MT-CO3/TPM1/ATP1B2/CACNA2D4/ATP1A1	-0.0868880700575126
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/669	103/9376	0.952472172638484	COL4A1/SLC38A2/ATP1B2/ATP1A1/SLC1A5/COL4A2/SLC3A2	-0.134437636648998
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/669	89/9376	0.94482793369275	SPP1/FN1/COL4A1/HSPG2/ITGA5/COL4A2	-0.144957588290534
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/669	13/9376	1.0780728987007	RAD50	0.0780780383565162
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/669	29/9376	0.966548116076491	CSNK1E/RASSF4	-0.0500089669846939
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/669	29/9376	0.966548116076491	CALML4/PDE6G	-0.0500089669846939
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/669	91/9376	0.924062484600601	PRKACA/GNG10/GNAS/GNAI1/GNG12/PRKCG	-0.201767192174664
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/669	30/9376	0.934329845540608	PCK2/SDHA	-0.099857387941394
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/669	62/9376	0.904190173103814	MAML1/NRARP/HES1/DLL1	-0.209798417647976
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	7/669	108/9376	0.908376238720035	DDX39B/RBM8A/NXF1/EIF4A3/IPO4/DDX19B/KPNA2	-0.265455303342125
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/669	47/9376	0.894571128709093	TNF/MAFA/PIK3R3	-0.200842382386438
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/669	63/9376	0.889837948133912	GADD45B/CDKN1A/GADD45G/AXIN2	-0.243176674200186
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/669	15/9376	0.934329845540608	AK1	-0.0705532411336683
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/669	32/9376	0.87593423019432	GALT/GLA	-0.194861020988848
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/669	49/9376	0.858058021414844	C1GALT1C1/GALNT4/COLGALT1	-0.276122839774512
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/669	33/9376	0.84939076867328	BCKDHA/ACY1	-0.240231422193713
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/669	16/9376	0.87593423019432	MIF	-0.137669731823071
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/669	144/9376	0.87593423019432	PSMB3/PSMA2/PSMC4/PSMA6/NOP56/AKT3/PIK3R3/PRKCG/PSMD9	-0.41586248808773
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/669	67/9376	0.836713294513977	LDHA/PCK2/TPI1/LDHC	-0.371792939206991
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/669	17/9376	0.824408687241713	KYAT1	-0.200852474974673
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/669	35/9376	0.800854153320521	TIGAR/TPI1	-0.327169653712559
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/669	101/9376	0.832571149491631	PRKACA/HRAS/CALML4/GNAS/GNAI1/PRKCG	-0.468919667295475
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/669	194/9376	0.866903980398502	TUBB/TUBB4B/DYNLRB1/TUBA1B/DYNLL1/TUBB2A/TPM1/MYO19/TUBB4A/TUBA1A/KIFC1/TUBA1C	-0.519232314682936
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/669	36/9376	0.778608204617173	PGM2L1/PYGL	-0.368895841332395
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/669	86/9376	0.814822539715646	LMNA/ITGA5/DMD/JUP/CACNA2D4	-0.478182762800274
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/669	37/9376	0.75756473962752	GALT/UGDH	-0.409553728590459
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/669	19/9376	0.737628825426796	BCKDHA	-0.317313851228643
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/669	56/9376	0.750800768737989	CCND2/PRKACA/CSNK1E	-0.518438422455242
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/669	191/9376	0.807143583843981	FOSB/ATF4/PRKACA/GNG10/HRAS/ATF6B/ADORA2A/CALML4/GNAS/GNAI1/GNG12	-0.746406856480435
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/669	42/9376	0.667378461100434	AOC1/KYAT1	-0.598832745220222
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/669	254/9376	0.82765439073479	PLCG2/FLT1/PRKACA/VEGFA/FGFR1/PPP3R1/PDGFB/ADORA2A/CALML4/GNAS/HTR2B/P2RX7/TFEB/PRKCG/P2RX5	-0.771856334803703
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/669	23/9376	0.609345551439527	B3GALNT2	-0.519930925294736
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/669	226/9376	0.806169556993002	JUN/FOS/NFKBIA/PRKACA/CGA/ATP1B2/ADORA2A/CALML4/GNAS/GNAI1/ATP1A1/AKT3/PIK3R3	-0.817579673817818
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/669	24/9376	0.58395615346288	NDST2	-0.565661863123605
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/669	166/9376	0.759846561132422	ATF4/ATF6B/NPPC/ATP1B2/PPP3R1/CALML4/GNAI1/ATP1A1/AKT3	-0.865321438664458
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/669	26/9376	0.539036449350351	PLA2G4B	-0.652396886250004
NA	NA	hsa04382	Cornified envelope formation	12/669	217/9376	0.775020148374698	PPP2CA/COL4A1/KRT7/ABHD5/PPP2R3B/KRT18/CLDN7/JUP/COL4A2/PRSS8/CLDN19/KRT19	-0.929424011684193
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/669	102/9376	0.687007239368094	ATP1B2/GNAS/ATP1A1/PRKCG/CA2	-0.880978394268969
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/669	27/9376	0.519072136411449	SCD	-0.693655232435596
NA	NA	hsa04081	Hormone signaling	12/669	219/9376	0.7679423388005	ADIPOR2/PRKACA/GNG10/CSH1/DIO2/CGA/NPPC/GNAS/GNAI1/PIK3R3/GNG12/VIPR1	-0.963176296235766
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/669	48/9376	0.58395615346288	BCKDHA/HMGCS1	-0.800995134096949
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/669	68/9376	0.618306515431285	DGAT1/DHRS4/RDH13	-0.875599370351585
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/669	28/9376	0.500533845825326	PPT2	-0.733652079208599
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/669	70/9376	0.600640614990391	HPGDS/GSTM3/SULT1A3	-0.929599359128208
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/669	30/9376	0.467164922770304	B3GALT4	-0.81022375314512
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/669	30/9376	0.467164922770304	PLA2G4B	-0.81022375314512
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/669	31/9376	0.452095086551907	UGDH	-0.846955931737776
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/669	31/9376	0.452095086551907	BAG6	-0.846955931737776
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/669	54/9376	0.519072136411449	TOP3A/HES1	-0.982396247830107
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/669	33/9376	0.42469538433664	STX16	-0.917647907754091
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/669	79/9376	0.532213203156042	ATP6V0C/AP2A2/NSF	-1.15732281528227
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/669	36/9376	0.389304102308587	UGDH	-1.01757690065958
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/669	37/9376	0.37878236981376	MIF	-1.04944304024921
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/669	195/9376	0.646843739220421	PLCG2/GSDMD/FCGR2A/AKT3/AGER/PIK3R3/PADI4/NCF4/PRKCG	-1.3813497286029
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/669	142/9376	0.592180888018695	SKP1/UBB/HERC3/HERC2/UBC/UBE2S	-1.35731683760031
NA	NA	hsa04082	Neuroactive ligand signaling	9/669	199/9376	0.633841855014985	PRKACA/GNG10/ADORA2A/GNAS/GNAI1/HTR2B/GNG12/PRKCG/P2RX5	-1.44713582988448
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/669	183/9376	0.612675308551218	FBL/CSNK2B/AK6/RMRP/NXF1/NOP56/GNL3/LSG1	-1.46668389508631
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/669	43/9376	0.325929015886259	ACADVL	-1.22798667070815
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/669	116/9376	0.483274058038245	SHMT1/TPI1/SDHA/SHMT2	-1.55220183225575
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/669	73/9376	0.38397116940025	HPGDS/GSTM3	-1.46458769959688
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/669	79/9376	0.354808802104028	HPGDS/GSTM3	-1.59622823598715
NA	NA	hsa04519	Cadherin signaling	18/669	404/9376	0.624428362118723	YWHAE/CDC42/NFKBIA/ACTN4/KRT7/HRAS/FMN1/FGFR1/KRT18/JUP/ARPC1B/PCDH9/AXIN2/CYFIP1/LRP6/CTNND1/KRT19/MAP2K3	-2.13896295526215
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/669	86/9376	0.162964507943129	PRKACA	-2.16147226308763
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/669	370/9376	0.454538843776512	CSH1/PTGIR/ADM/CHRNB1/CGA/ADORA2A/LTB4R/HTR2B/S1PR2/P2RX7/P2RX5/VIPR1	-2.96731153132119
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/669	449/9376	0.0624273838891275	PRKACA/CALML4	-5.64338581613342