category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	30/362	180/9376	4.31675874769797	HLA-E/NFKBIA/HLA-F/IL1B/TNFSF14/ITGA5/HLA-A/HLA-DRB1/CD74/TAPBP/IRF7/TNFRSF14/SRSF3/IFIH1/HLA-B/HLA-DRA/CFP/HLA-G/TAP1/BIRC3/OAS2/HLA-DQA1/EIF2AK2/APAF1/OAS3/MYD88/HLA-C/OAS1/TNF/SP100	9.00392359605379
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	32/362	205/9376	4.04301307101469	PLCG2/HLA-E/NFKBIA/JUN/NFKB2/HLA-F/ISG15/CCND3/NFKBIE/HLA-A/HLA-DRB1/TNFAIP3/TAPBP/IRF7/MAP2K3/HLA-B/HLA-DRA/HLA-G/TAP1/GADD45B/OAS2/VIM/CDKN1A/HLA-DQA1/EIF2AK2/APAF1/OAS3/MYD88/HLA-C/ICAM1/OAS1/TNF	8.82782160509042
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	18/362	82/9376	5.6854871311144	HLA-E/IFI30/HLA-F/CTSB/HSP90AA1/HLA-A/HLA-DRB1/CD74/TAPBP/LGMN/HLA-B/HLA-DRA/HSP90AB1/HLA-G/TAP1/HLA-DQA1/HLA-C/TNF	8.53967785814584
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	31/362	238/9376	3.37360137425136	PLCG2/NFKBIA/JUN/C1QA/ISG15/IL1B/C3AR1/C1QB/MX1/ADAM17/C1QC/F13A1/RPLP0/RPS9/RPS2/ADAR/IFIH1/MX2/RPS4Y1/RPS19/OAS2/FOS/RPL36A/EIF2AK2/OAS3/RPL18/MYD88/OAS1/TNF/RPS16/C5AR1	7.4327894907998
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	18/362	95/9376	4.90747310264612	JUN/VEGFA/CCL3/LTB/IL1B/FLT1/ITGB2/ATP6V1B2/HLA-DRB1/CCL3L1/HLA-DRA/ATP6V0D1/TGFB1/FOS/CCL20/HLA-DQA1/ICAM1/TNF	7.67081590589727
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	28/362	224/9376	3.23756906077348	HLA-E/NFKBIA/TLN1/JUN/NFKB2/HLA-F/SPI1/CCND3/ATF4/ITGB2/HLA-A/HLA-DRB1/IL1R2/GPS2/HLA-B/HLA-DRA/HLA-G/ETS2/TGFB1/FOS/CDKN1A/HLA-DQA1/MAP3K3/HLA-C/PRKACA/ICAM1/CRTC2/TNF	6.79240539707561
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	22/362	155/9376	3.67620744965247	HLA-E/NCF1/HLA-F/CORO1A/FCAR/ITGA5/ITGB2/ATP6V1B2/HLA-A/HLA-DRB1/CD14/OLR1/HLA-B/HLA-DRA/HLA-G/TAP1/ATP6V0D1/TUBB4B/HLA-DQA1/HLA-C/DYNC1LI1/TUBA1B	6.73252167024414
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	27/362	227/9376	3.08068245430428	HLA-E/NFKBIA/VEGFA/CCL3/HLA-F/CCL4/IL1B/ATF4/HLA-A/GRB2/CCL3L1/TAPBP/HLA-B/HLA-G/TAP1/ARHGEF1/PLCB2/CDKN1A/CCL4L2/HLA-C/PRKACA/PTGER4/TNF/CALM2/GNB2/GNAI2/ROCK1	6.35935495499547
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	26/362	216/9376	3.11765909555965	NFKBIA/NCF1/JUN/CCL3/IL1B/ATF4/HSP90AA1/CCL3L1/RXRA/IRF7/MAP2K3/CD14/OLR1/HSP90AB1/ARHGEF1/SOD2/FOS/PLCB2/XBP1/APAF1/MYD88/ABCG1/ICAM1/ERN1/TNF/CALM2	6.30981074423048
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	17/362	105/9376	4.19342278347803	PLCG2/NFKBIA/NFKB2/CCL4/LTB/IL1B/TNFSF14/PLAU/CFLAR/TNFAIP3/CD14/GADD45B/BIRC3/CCL4L2/MYD88/ICAM1/TNF	6.59430340207988
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/362	44/9376	6.47513812154696	HLA-E/HLA-F/IL1B/HLA-A/HLA-DRB1/HLA-B/HLA-DRA/HLA-G/HLA-DQA1/HLA-C/TNF	7.29483040186444
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/362	45/9376	6.33124616329036	HLA-E/HLA-F/IL1B/HLA-A/HLA-DRB1/HLA-B/HLA-DRA/HLA-G/HLA-DQA1/HLA-C/TNF	7.18376380523143
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	22/362	173/9376	3.29371187685626	NFKBIA/IL1B/CCND3/RSAD2/MX1/HLA-DRB1/ADAR/IRF7/IFIH1/MX2/HLA-DRA/OAS2/HLA-DQA1/EIF2AK2/APAF1/DNAJB1/OAS3/MYD88/ICAM1/OAS1/PABPN1/TNF	6.10208637125044
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	24/362	205/9376	3.03225980326102	HLA-E/NFKBIA/JUN/NFKB2/HLA-F/CCND3/ATF4/HLA-A/GRB2/YWHAE/IRF7/HLA-B/ACTN4/HLA-G/CHD4/ATP6V0D1/PMAIP1/CDKN1A/EIF2AK2/HLA-C/PRKACA/PKM/SP100/DDX3X	5.89561286123632
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/362	78/9376	4.64881711290551	JUN/IRF1/C1QA/IL1B/ITGA5/ITGB2/C1QB/C1QC/CD14/FOS/MYD88/TNF/CALM2/GNAI2	6.48463853988044
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/362	39/9376	6.64116730415073	HLA-E/HLA-F/HLA-A/HLA-DRB1/HLA-B/HLA-DRA/HLA-G/HLA-DQA1/HLA-C/TNF	7.07422307971912
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/362	103/9376	4.02338679397093	NFKBIA/JUN/CCL3/C1QA/IL1B/C1QB/CFLAR/C1QC/CCL3L1/SERPINE1/TGFB1/FOS/PLCB2/MYD88/TNF/GNAI2	6.18277355689328
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/362	142/9376	3.46556688195471	PLCG2/SQSTM1/NFKBIA/NCF1/JUN/NFKB2/FOSB/IL1B/SPI1/LILRB3/GRB2/LILRA2/CSF1R/TGFB1/FOS/JUND/OSCAR/JUNB/TNF	5.93262874315341
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/362	136/9376	3.42801429964251	NFKBIA/JUN/IL1B/CCND3/MX1/TNFAIP3/ADAR/IRF7/IFIH1/MX2/OAS2/FOS/EIF2AK2/APAF1/OAS3/RACK1/MYD88/OAS1	5.71565300842424
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	15/362	99/9376	3.92432613427089	C1QA/FCAR/C3AR1/ITGB2/C1QB/C1QC/HLA-DRB1/HLA-DRA/KRT19/KRT18/HLA-DQA1/KRT23/ICAM1/PTAFR/C5AR1	5.86166198545833
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/362	78/9376	4.31675874769797	NFKBIA/NCF1/JUN/IL1B/ITGB2/HLA-DRB1/HLA-DRA/TGFB1/FOS/HLA-DQA1/MARCKSL1/MYD88/TNF	5.89450798362467
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/362	187/9376	2.90861819363607	NFKBIA/JUN/TXNIP/CTSB/IL1B/HSP90AA1/TNFAIP3/YWHAE/IRF7/NLRP1/HSP90AB1/BIRC3/OAS2/PLCB2/GSDMD/OAS3/MYD88/OAS1/TNF/NLRP12/MFN2	5.28307630613317
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/362	119/9376	3.48242722503366	NFKBIA/JUN/IRF1/IL1B/ATF4/CFLAR/ADAM17/TNFAIP3/MAP2K3/BIRC3/FOS/CCL20/TNFRSF1B/ICAM1/JUNB/TNF	5.46129983828503
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	17/362	137/9376	3.21393716981893	NFKBIA/JUN/CTSD/CTSB/ATF4/CFLAR/CTSZ/GADD45B/BIRC3/PMAIP1/MCL1/FOS/APAF1/ERN1/TNF/LMNA/TUBA1B	5.23111464750693
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/362	139/9376	3.16769346953377	JUN/CTSD/ATF4/FKBP5/HSP90AA1/GRB2/KRT19/HSP90AB1/KRT18/FOS/PLCB2/GABBR1/KRT23/PRKACA/CALM2/GNAI2/POMC	5.15965833402822
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/362	54/9376	4.7963986085533	HLA-E/HLA-F/CGA/HLA-A/HLA-DRB1/HLA-B/HLA-DRA/HLA-G/HLA-DQA1/HLA-C	5.60654461872632
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	27/362	300/9376	2.33104972375691	JUN/VEGFA/NFKB2/DUSP2/FLNA/IL1B/FLT1/ATF4/GRB2/IGF2/MAP3K11/MAP2K3/CD14/NR4A1/CSF1R/DUSP9/GADD45B/TGFB1/FOS/JUND/MAP3K3/RPS6KA1/MYD88/PRKACA/DUSP6/TNF/MEF2C	4.69557530577584
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/362	144/9376	3.05770411295273	NFKBIA/C1QA/IL1B/C3AR1/C1QB/C1QC/MAP2K3/CD14/ALDH3A2/ALDH2/LPIN2/MYD88/TNF/ACADVL/SIRT1/C5AR1/ADIPOR2	4.98651833669618
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/362	70/9376	4.07008681925809	HLA-E/HLA-F/ITGB2/HLA-A/HLA-DRB1/HLA-B/HLA-DRA/HLA-G/HLA-DQA1/HLA-C/ICAM1	5.16653409356116
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/362	109/9376	3.32667646611587	SPP1/NFKBIA/JUN/CCL3/CCL4/IL1B/CCL3L1/IRF7/MAP2K3/CD14/FOS/CCL4L2/MYD88/TNF	4.89621873228095
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/362	109/9376	3.32667646611587	NFKBIA/JUN/IL1B/NFKBIE/HSP90AA1/HLA-DRB1/RXRA/HLA-DRA/HSP90AB1/TGFB1/FOS/HLA-DQA1/STAT6/EBI3	4.89621873228095
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	28/362	333/9376	2.17782423307285	SPP1/FN1/HLA-E/VEGFA/IRF1/HLA-F/ISG15/ITGA5/CCND3/OASL/MX1/ATP6V1B2/HLA-A/GRB2/HES4/MX2/COL4A1/HLA-B/HLA-G/CHD4/ATP6V0D1/CDKN1A/EIF2AK2/HLA-C/PRKACA/PTGER4/TNF/PKM	4.38558450105164
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/362	156/9376	2.82249610426406	NFKBIA/RSAD2/MX1/IFIT1/CFLAR/GRB2/RXRA/YWHAE/IRF7/MX2/OAS2/CDKN1A/EIF2AK2/APAF1/OAS3/OAS1/TNF	4.59985978899257
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/362	50/9376	4.66209944751381	IL1B/ITGB2/HBA2/HBA1/TGFB1/LRP1/MYD88/ICAM1/TNF	5.20293711652885
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	19/362	196/9376	2.51076784304882	PLCG2/HLA-E/NFKBIA/JUN/VEGFA/HLA-F/UBC/HLA-A/IRF7/HLA-B/ATG3/HLA-G/FOS/CDKN1A/EIF2AK2/HLA-C/ICAM1/CALM2/GNB2	4.28336983500149
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/362	142/9376	2.73597385417477	SQSTM1/NCF1/JUN/VEGFA/IL1B/HSP90AA1/IL1R2/KLF2/HSP90AB1/FOS/ICAM1/TNF/CALM2/MGST3/MEF2C	4.17708741142526
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/362	37/9376	4.90010452441392	IL1B/HBA2/HBA1/PLCB2/MYD88/ICAM1/TNF	4.76330145296785
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	16/362	163/9376	2.5423855201166	NFKBIA/JUN/ATF4/GRB2/IRF7/MAP2K3/IFIH1/TGFB1/FOS/CDKN1A/STAT6/HSPG2/APAF1/MYD88/TNF/DDX3X	3.98077244647865
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/362	103/9376	3.0175400954782	FN1/IL1B/ITGB2/IL1R2/CD14/COL4A1/ACTN4/TGFB1/PRDX1/PLCB2/PRKACA/TNF	4.12583450360023
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	19/362	214/9376	2.29958176279238	PLCG2/HLA-E/NFKBIA/JUN/HLA-F/HLA-A/TAPBP/MAP2K3/HLA-B/HLA-G/TAP1/FOS/MYD88/HLA-C/TNFRSF1B/TNF/CALM2/GNB2/GNAI2	3.85386500359512
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	17/362	181/9376	2.43264857605079	PLK3/CTSD/CORO1A/IL1B/LSP1/ITGB2/HLA-DRB1/CD74/CD14/HLA-DRA/ATP6V0D1/TGFB1/HLA-DQA1/APAF1/MYD88/TNF/CALM2	3.90017630709034
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	21/362	250/9376	2.17564640883978	SMAP2/HLA-E/HLA-F/EHD1/RAB11FIP1/ACAP1/IGF2R/HLA-A/DAB2/VPS37B/HLA-B/FOLR2/HLA-G/GRK2/SPART/CYTH1/GRK6/CBL/HLA-C/ARPC1B/CLTA	3.77561445655739
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	14/362	138/9376	2.62759228120746	FN1/NFKBIA/JUN/IL1B/ITGA5/MAP2K3/ARHGEF1/FOS/RPS6KA1/MYD88/ARPC1B/TNF/BAIAP2/ROCK1	3.85991136773372
NA	NA	hsa04518	Integrin signaling	15/362	154/9376	2.522781086317	SPP1/FN1/TLN1/VEGFA/FLNA/FLT1/ITGA5/CCND3/ITGB2/ICAM3/COL4A1/ACTN4/PARVG/TGFB1/ICAM1	3.81826812595579
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/362	66/9376	3.5318935208438	JUN/IL1B/IL18RAP/HLA-DRB1/HLA-DRA/TGFB1/HLA-DQA1/STAT6/TNF	4.13641125629434
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/362	94/9376	3.03091571646879	NFKBIA/JUN/FOSB/IL1B/HSP90AA1/TNFAIP3/HSP90AB1/FOS/CCL20/JUND/TNF	3.96566652911337
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	15/362	157/9376	2.4745750782982	SQSTM1/HLA-E/HLA-F/CCND3/HLA-A/SERPINE1/MAP2K3/HLA-B/HLA-G/GADD45B/TGFB1/CDKN1A/HLA-C/CALM2/SIRT1	3.73384215834609
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/362	193/9376	2.28139581484556	PLCG2/NFKBIA/NCF1/CCL3/CCL4/FGR/GRB2/CCL3L1/GRK2/CCL20/PLCB2/GRK6/CCL4L2/PRKACA/GNB2/GNAI2/ROCK1	3.60454797487303
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/362	56/9376	3.70007892659826	NFKBIA/NFKB2/IL1B/ITGB2/CD14/APAF1/MYD88/TNF	4.06109980918274
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	20/362	248/9376	2.08875423275708	NFKBIA/JUN/FLNA/IL1B/HSP90AA1/MAP2K3/CD14/PLEKHM1/HSP90AB1/BIRC3/CYTH1/FOS/TUBB4B/GSDMD/CYFIP1/MYD88/DYNC1LI1/ARPC1B/TNF/TUBA1B	3.48216244804229
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/362	100/9376	2.84906077348066	CCL3/CCL4/TNFSF14/IL18RAP/CCL3L1/TNFRSF14/CSF1R/CCL20/CCL4L2/TNFRSF1B/TNF	3.72522030988091
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/362	101/9376	2.82085225097095	PLCG2/FN1/JUN/VEGFA/IL1B/SERPINE1/COL4A1/TGFB1/PLCB2/ICAM1/TNF	3.68688491720345
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	17/362	201/9376	2.19059399136912	FLT1/SPI1/PLAU/FUS/IL1R2/RXRA/CD14/CEBPA/CSF1R/GADD45B/BIRC3/CDKN1A/MLLT1/DUSP6/HPGD/EWSR1/MEF2C	3.41932062019158
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/362	88/9376	2.94324460070316	C1QA/C3AR1/PLAU/ITGB2/C1QB/C1QC/F13A1/SERPINE2/SERPINE1/C5AR1	3.67019254729583
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/362	203/9376	2.1690117845576	SPP1/FN1/TLN1/JUN/VEGFA/FLNA/FLT1/ITGA5/CCND3/VASP/GRB2/COL4A1/ACTN4/PARVG/BIRC3/ZYX/ROCK1	3.3743673327851
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/362	75/9376	3.10806629834254	CCND3/CD82/SHISA5/SERPINE1/GADD45B/PMAIP1/CDKN1A/APAF1/SESN2	3.67308705306899
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/362	160/9376	2.26629834254144	HLA-E/HLA-F/ITGB2/ICAM3/HLA-A/HLA-DRB1/HLA-B/HLA-DRA/HLA-G/VSIR/HLA-DQA1/HLA-C/SIGLEC1/ICAM1	3.23747142078757
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/362	112/9376	2.54380426203631	NFKBIA/PPIF/HLA-DRB1/MAP2K3/HLA-DRA/BIRC3/TGFB1/HLA-DQA1/MYD88/TNF/GNAI2	3.29369302656933
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/362	130/9376	2.39082022949426	NFKBIA/JUN/VEGFA/ATF4/GRB2/COL4A1/TGFB1/FOS/PLCB2/PRKACA/GNB2/GNAI2	3.19997714927311
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/362	200/9376	2.07204419889503	NFKBIA/JUN/MYO1F/IL1B/ARHGEF1/CYTH1/FOS/TUBB4B/CYFIP1/MYD88/ARPC1B/TNF/BAIAP2/NCL/ROCK1/TUBA1B	3.07101638146038
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	11/362	115/9376	2.47744415085275	NR4A2/ATF4/RXRA/ARHGEF1/FOS/PLCB2/JUND/CDKN1A/PRKACA/GNAI2/MEF2C	3.1945684462997
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/362	204/9376	2.03141588126964	PLCG2/FN1/VEGFA/FLNA/ITGA5/PLAU/GRB2/IGF2/ARHGEF1/TGFB1/CDKN1A/CBL/HSPG2/PRKACA/TNF/ROCK1	2.98468169087472
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/362	298/9376	1.82520671882532	CCL3/CCL4/LTB/IL1B/TNFSF14/CSH1/IL1RN/IL18RAP/CCL3L1/IL1R2/TNFRSF14/CSF1R/RELT/OSM/TGFB1/CCL20/CCL4L2/EBI3/TNFRSF1B/TNF/INHBA	2.90106156147104
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/362	362/9376	1.71716370074174	SPP1/FN1/VEGFA/FLT1/CSH1/ITGA5/CCND3/ATF4/HSP90AA1/GRB2/DDIT4/IGF2/RXRA/YWHAE/COL4A1/NR4A1/CSF1R/HSP90AB1/OSM/MCL1/CDKN1A/CRTC2/GNB2/CDC37	2.78865606598279
Human Diseases	Immune disease	hsa05310	Asthma	5/362	32/9376	4.04696132596685	HLA-DRB1/HLA-DRA/PRG2/HLA-DQA1/TNF	3.45984515784561
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	10/362	105/9376	2.46671928439884	PLCG2/PLK3/NFKBIA/JUN/IRF1/NFKB2/IL1B/LSP1/TNF/CALM2	3.02872266617747
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/362	157/9376	2.14463173452511	DUSP2/C1QA/C1QB/ADAM17/C1QC/STAB1/RXRA/SCARF1/TGFB1/LRP1/BSG/PTGER4/SIRT1	2.89837681990605
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	13/362	157/9376	2.14463173452511	JUN/IL1B/MT-CO3/ATF4/RXRA/MAP3K11/CEBPA/TGFB1/FOS/XBP1/ERN1/TNF/ADIPOR2	2.89837681990605
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/362	268/9376	1.83623319864765	PPIF/UBC/MT-CO3/MT-ATP6/ATF4/MT-ND2/MT-ND1/MT-ND5/MT-ATP8/XBP1/TUBB4B/APAF1/PRKACA/ERN1/CALM2/ADORA2A/GNAI2/MFN2/TUBA1B	2.78332831535263
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	18/362	250/9376	1.86483977900552	PSAP/CTSD/CTSB/ATP6V1B2/IGF2R/BORCS5/LGMN/GLA/HEXB/CTSZ/PLEKHM1/MCOLN1/ATP6V0D1/SLC11A1/CLN3/AP5Z1/CD68/CLTA	2.77745208735134
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/362	91/9376	2.56159310302957	PLCG2/NFKBIA/JUN/LILRB3/NFKBIE/GRB2/LILRA2/INPP5D/FOS	2.99970654675051
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/362	93/9376	2.5065050793085	JUN/ATF4/CGA/GRB2/MAP2K3/PLCB2/MAP3K3/PRKACA/CALM2	2.92582971223404
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	19/362	275/9376	1.78949271722752	NCF1/PPIF/C1QA/IL1B/MT-CO3/MT-ATP6/ATF4/MT-ND2/C1QB/C1QC/MT-ND1/MT-ND5/MT-ATP8/TUBB4B/APAF1/PRKACA/TNF/STIP1/TUBA1B	2.66287674204443
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/362	37/9376	3.50007466029565	TPM3/NCOA4/RXRA/GADD45B/CDKN1A	3.05340771955437
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/362	133/9376	2.14215095750426	PLCG2/HLA-E/ITGB2/HLA-A/GRB2/HLA-B/HLA-G/LAT2/HLA-C/ICAM1/TNF	2.65842246777913
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	13/362	169/9376	1.99235019124522	SQSTM1/ATG2A/UBC/CTSD/CTSB/CFLAR/DDIT4/VMP1/PLEKHM1/ATG3/ATG16L2/PRKACA/ERN1	2.60873752365914
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/362	52/9376	2.98852528686783	APOE/PLTP/APOC1/APOC2/CYP27A1/LRP1	2.88146138574995
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/362	100/9376	2.33104972375691	IL1B/ITGA5/HLA-DRB1/IL1R2/CD14/HLA-DRA/CSF1R/HLA-DQA1/TNF	2.68160654074492
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/362	154/9376	2.0182248690536	JUN/RGS2/FOS/PLCB2/CDKN1A/PRKACA/EEF2/CALM2/KCNJ2/GNAI2/MEF2C/ROCK1	2.55312835015967
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/362	69/9376	2.62759228120746	CTSB/PLCB2/PRKACA/PTGER4/CALM2/KCNJ2/GNAI2	2.71923321579857
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/362	69/9376	2.62759228120746	JUN/FOSB/ATF4/FOS/PRKACA/CALM2/SIRT1	2.71923321579857
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	10/362	120/9376	2.15837937384899	PLCG2/NFKBIA/JUN/ATF4/NFKBIE/GRB2/YWHAE/MAP3K3/RPS6KA1/CALM2	2.55923939605091
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/362	70/9376	2.59005524861878	NFKBIA/NFKBIE/RXRA/TNFRSF1B/TNF/POMC/ADIPOR2	2.67584440970958
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/362	87/9376	2.38165999872992	JUN/RALGDS/GRB2/GADD45B/TGFB1/PMAIP1/FOS/CDKN1A	2.59452270563924
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/362	122/9376	2.12299610542523	PLCG2/CSH1/ATF4/GRB2/MAP2K3/FOS/PLCB2/PRKACA/JUNB/GNAI2	2.50192659999283
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/362	72/9376	2.51810926949048	NFKBIA/ISG15/ADAR/IRF7/IFIH1/TNF/DDX3X	2.59128735642163
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/362	106/9376	2.19910351297821	NFKBIA/PLAU/ATF4/HSP90AA1/GRB2/IL1R2/HSP90AB1/FOLR2/CDKN1A	2.48800293007978
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/362	93/9376	2.22800451494089	NFKBIA/JUN/NFKBIE/HLA-DRB1/HLA-DRA/FOS/HLA-DQA1/STAT6	2.38494522582081
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/362	93/9376	2.22800451494089	FN1/NFKBIA/RXRA/COL4A1/GADD45B/BIRC3/CDKN1A/APAF1	2.38494522582081
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	22/362	368/9376	1.54840259428297	SQSTM1/ATG2A/MT-CO3/MT-ATP6/ATF4/MT-ND2/FUS/MT-ND1/TOMM40L/HNRNPA2B1/SRSF3/MAP2K3/MT-ND5/MT-ATP8/XBP1/TUBB4B/APAF1/TNFRSF1B/ERN1/TNF/HNRNPA3/TUBA1B	2.15075216025121
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/362	227/9376	1.71149025239127	NFKBIA/NCF1/JUN/VEGFA/PPIF/MT-CO3/MT-ATP6/MT-ND2/MT-ND1/GRB2/MT-ND5/SOD2/MT-ATP8/FOS/MGST3	2.17458413830297
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/362	253/9376	1.63797960386959	PLCG2/SQSTM1/NFKBIA/TLN1/JUN/UBC/IL1B/ITGA5/CD14/ACTN4/CYTH1/PLCB2/MYD88/ARPC1B/TNF/ROCK1	2.06148113267821
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/362	65/9376	2.39082022949426	GLA/ALDH3A2/DGKZ/PNPLA2/ALDH2/LPIN2	2.25481367710044
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/362	49/9376	2.64291351899876	JUN/FOSB/ATF4/PRKACA/GNAI2	2.31059006437065
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/362	83/9376	2.18438394461825	NFKBIA/CCL4/IL1B/ADAR/IRF7/CCL4L2/GSDMD	2.17187454716393
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/362	217/9376	1.67100338620567	JUN/VEGFA/CCND3/ATF4/HSP90AA1/GRB2/RXRA/HSP90AB1/FOS/RPS6KA1/PRKACA/KLF5/MGST3/GNAI2	2.0040645038583
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/362	50/9376	2.59005524861878	AOC1/ALDH3A2/AMD1/ALDH2/LAP3	2.25907504395782
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/362	103/9376	2.01169339698546	EIF4A3/FUS/DDX39B/PCF11/RBM8A/UPF1/PNN/PABPN1	2.06889545030718
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	22/362	388/9376	1.46858802756735	APOE/ATG2A/PPIF/IL1B/MT-CO3/MT-ATP6/ATF4/MT-ND2/ADAM17/MT-ND1/MT-ND5/MT-ATP8/PLCB2/XBP1/TUBB4B/EIF2AK2/APAF1/LRP1/ERN1/TNF/CALM2/TUBA1B	1.8891074715658
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/362	68/9376	2.28534286642834	SPI1/GRB2/CD14/CEBPA/CSF1R/DUSP6	2.13170158067011
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/362	105/9376	1.97337542751907	SQSTM1/JUN/UBC/ATF4/TOMM40L/RABGEF1/FKBP8/MFN2	2.00998531306249
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/362	143/9376	1.81122744658656	C1QA/C1QB/C1QC/HLA-DRB1/HLA-DRA/ACTN4/HLA-DQA1/H2AC6/TNF/SNRPB	1.95893661330999
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/362	22/9376	3.5318935208438	AOC1/ALDH3A2/ALDH2	2.38253473880758
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/362	70/9376	2.22004735595896	JUN/VEGFA/GRB2/TGFB1/CDKN1A/EGLN2	2.05317198874668
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/362	71/9376	2.18877908333982	PLCG2/NFKBIA/JUN/ATP6V1B2/ADAM17/ATP6V0D1	2.01489902755383
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/362	38/9376	2.72637394591451	NADK/NAPRT/SIRT2/SIRT1	2.13688368477261
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	7/362	90/9376	2.01448741559239	NFKBIA/JUN/NFKBIE/MAP2K3/FOS/MAP3K3/MYD88	1.93791500656865
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/362	168/9376	1.6958695080242	SQSTM1/IL1B/CFLAR/HSP90AA1/TNFAIP3/HSP90AB1/BIRC3/STAT6/EIF2AK2/H2AC6/TNF	1.82381565373052
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	13/362	212/9376	1.58824142603982	TLN1/VEGFA/RALGDS/FLT1/ITGB2/VASP/MAP2K3/CSF1R/PLCB2/RGS14/CALM2/ADORA2A/GNAI2	1.73604965407591
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/362	77/9376	2.0182248690536	VEGFA/RALGDS/RALBP1/GADD45B/TGFB1/CDKN1A	1.7978443324114
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/362	77/9376	2.0182248690536	NFKBIA/GRB2/GADD45B/TGFB1/CDKN1A/CBL	1.7978443324114
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/362	59/9376	2.19496207510066	CGA/ABHD5/PNPLA2/PRKACA/GNAI2	1.84511409649104
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	25/362	480/9376	1.34898710865562	SQSTM1/ATG2A/PPIF/UBC/IL1B/MT-CO3/MT-ATP6/ATF4/MT-ND2/FUS/MT-ND1/TOMM40L/MAP2K3/MT-ND5/MT-ATP8/PLCB2/XBP1/TUBB4B/APAF1/TNFRSF1B/ERN1/TNF/CALM2/MFN2/TUBA1B	1.57294581725736
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/362	116/9376	1.78624499904744	PLCG2/NCF1/ITGB2/VASP/ACTN4/ICAM1/GNAI2/ROCK1	1.70750720135791
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/362	98/9376	1.85003946329913	PLCG2/ITPK1/PIP4P1/DGKZ/INPP5D/PLCB2/CALM2	1.69514201709883
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/362	98/9376	1.85003946329913	NR4A2/ATF4/NR4A1/PLCB2/PRKACA/CALM2/POMC	1.69514201709883
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/362	99/9376	1.83135219599308	PLCG2/IL1B/MAP2K3/PLCB2/PRKACA/PTGER4/CALM2	1.66640290447458
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/362	140/9376	1.66503551696922	SPP1/SERPINE1/KLF2/PLCB2/PRKACA/CALM2/GNB2/GNAI2/MEF2C	1.58872248543421
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/362	226/9376	1.4898547890285	NFKBIA/JUN/CGA/FOS/FFAR2/GABBR1/HCAR2/PRKACA/CALM2/ADORA2A/GNAI2/ROCK1/POMC	1.49379904478769
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	12/362	205/9376	1.51612990163051	NCF1/PPIF/CTSD/MT-CO3/MT-ATP6/MT-ND2/MT-ND1/MT-ND5/MT-ATP8/TGFB1/PLCB2/G6PD	1.49729974545515
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/362	65/9376	1.99235019124522	ATF4/NR4A1/PLCB2/PRKACA/POMC	1.6088094897114
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/362	104/9376	1.74330641733957	MBOAT7/LPCAT1/DGKZ/PLD3/CRLS1/LPIN2/PHOSPHO1	1.52749215019066
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/362	30/9376	2.59005524861878	IL1B/FOLR2/TNF	1.74799868001907
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/362	166/9376	1.56027424615589	PPIF/ATF4/VASP/RGS2/PLCB2/GTF2I/CALM2/GNAI2/MEF2C/ROCK1	1.45950650660797
Organismal Systems	Immune system	hsa04611	Platelet activation	8/362	126/9376	1.64447952293256	PLCG2/TLN1/VASP/ARHGEF1/PLCB2/PRKACA/GNAI2/ROCK1	1.4595019374713
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/362	67/9376	1.93287705120805	ATF4/PLCB2/RPS6KA1/PRKACA/CALM2	1.53564716509557
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	13/362	233/9376	1.44509520309203	FN1/TLN1/FMNL1/ITGA5/TPM3/PLEC/COL4A1/VIM/ZYX/HSPG2/DAAM2/DSP/LMNA	1.37869328719089
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/362	107/9376	1.6944286673207	ATF4/PLCB2/PRKACA/CRTC2/CALM2/SIRT1/PKM	1.44771887077362
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/362	32/9376	2.42817679558011	BIRC3/PMAIP1/APAF1	1.62170439402192
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/362	16/9376	3.23756906077348	GLA/HEXB	1.79506286198534
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/362	50/9376	2.07204419889503	HLA-DRB1/HLA-DRA/TGFB1/HLA-DQA1	1.52310952581506
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/362	69/9376	1.8768516294339	PLCG2/GRB2/MAP2K3/INPP5D/TNF	1.46496398613717
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/362	89/9376	1.74610466199019	GRB2/PLCB2/TUBB4B/PRKACA/GNAI2/TUBA1B	1.41722296397134
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/362	89/9376	1.74610466199019	SLC38A2/GLS/GABBR1/PRKACA/GNB2/GNAI2	1.41722296397134
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/362	238/9376	1.41473606016992	PLCG2/VEGFA/RALGDS/FLT1/GRB2/IGF2/RALBP1/CSF1R/ETS2/PRKACA/RGL2/CALM2/GNB2	1.29872094907217
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/362	51/9376	2.03141588126964	PLCG2/ATP6V1B2/ATP6V0D1/PRKACA	1.48004741453169
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/362	33/9376	2.35459568056253	STX4/VAMP1/STX6	1.56208487935815
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/362	90/9376	1.72670349907919	ATF4/SOD2/SESN2/PRKACA/SIRT1/ADIPOR2	1.38817849738349
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/362	91/9376	1.70772873535304	GRK2/GRK6/GABBR1/PRKACA/GNB2/GNAI2	1.3594953234894
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	16/362	308/9376	1.34548324603573	ATG2A/PPIF/MT-CO3/MT-ATP6/MT-ND2/MT-ND1/MT-ND5/SOD2/MT-ATP8/PLCB2/TUBB4B/APAF1/POLR2A/ERN1/CLTA/TUBA1B	1.23545730191486
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/362	133/9376	1.55792796909401	PLK3/GRB2/KLF2/SOD2/GADD45B/TGFB1/CDKN1A/SIRT1	1.29860964410771
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/362	73/9376	1.77401044425944	PLCG2/GRB2/RXRA/GADD45B/CDKN1A	1.33038667729746
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/362	115/9376	1.57655536872448	ATF4/FOS/PLCB2/PRKACA/GNB2/KCNJ2/GNAI2	1.24664312177812
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/362	116/9376	1.56296437416651	GRK2/SLC38A2/PLCB2/GLS/PRKACA/GNB2/GNAI2	1.22260329052887
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/362	75/9376	1.72670349907919	BIRC3/PMAIP1/CDKN1A/APAF1/MGST3	1.26620553442099
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/362	138/9376	1.50148130354712	MT-CO3/MT-ATP6/MT-ND2/ATP6V1B2/MT-ND1/MT-ND5/MT-ATP8/ATP6V0D1	1.1892864119701
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/362	76/9376	1.70398371619657	UBC/PLTP/RXRA/CYP27A1/OLR1	1.23483543079673
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/362	76/9376	1.70398371619657	PLCB2/PRKACA/CALM2/KCNJ2/GNAI2	1.23483543079673
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/362	76/9376	1.70398371619657	PLCG2/GRB2/GADD45B/CDKN1A/CALM2	1.23483543079673
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/362	97/9376	1.60209603007348	FOS/PLCB2/PRKACA/CALM2/GNB2/GNAI2	1.19448909724829
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/362	98/9376	1.58574811139926	PLCG2/NCF1/VASP/INPP5D/MARCKSL1/ARPC1B	1.16809428025314
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/362	38/9376	2.04478045943588	HEXB/AMDHD2/GNPDA1	1.29321594734512
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/362	78/9376	1.66029182603768	PLCG2/ITPK1/INPP5D/PLCB2/ISYNA1	1.17346353357855
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/362	78/9376	1.66029182603768	FN1/ITGA5/CBL/ARPC1B/CLTA	1.17346353357855
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/362	21/9376	2.46671928439884	ALDH3A2/ALDH2	1.34839117094277
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/362	41/9376	1.89516237703813	VEGFA/TYMP/CDKN1A	1.15111240642394
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/362	105/9376	1.48003157063931	ITGA5/TPM3/TGFB1/PRKACA/TNF/LMNA	0.991247959947517
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/362	42/9376	1.85003946329913	AOC1/ALDH3A2/ALDH2	1.1063969807055
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/362	23/9376	2.25222195532068	GLS/ASL	1.2048997422481
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/362	174/9376	1.33968374928558	PPP1R15A/ERO1B/ATF4/HSP90AA1/HSP90AB1/XBP1/DNAJB1/ERN1/DNAJA1	0.90633640905782
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/362	43/9376	1.80701528973404	ALDH3A2/ALDH2/ACADVL	1.06288555391432
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/362	86/9376	1.50584607477836	PLCG2/JUN/GRB2/CDKN1A/CBL	0.944367210703589
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/362	44/9376	1.7659467604219	STX4/PRKACA/DYNC1LI1	1.02051338068464
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/362	65/9376	1.59388015299618	SPP1/CGA/PLCB2/GABBR1	0.962805302322359
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/362	110/9376	1.41275740833752	PLCG2/VEGFA/FLT1/SERPINE1/CDKN1A/EGLN2	0.872622120945661
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/362	110/9376	1.41275740833752	EMP3/TGFB1/TNF/INHBA/SKIL/ROCK1	0.872622120945661
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/362	110/9376	1.41275740833752	HSP90AA1/HSP90AB1/RPS6KA1/PRKACA/AURKA/GNAI2	0.872622120945661
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/362	133/9376	1.36318697295725	ATF4/FOS/PLCB2/PRKACA/CALM2/GNB2/GNAI2	0.845338702883902
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/362	89/9376	1.45508721832516	SPP1/FN1/ITGA5/COL4A1/HSPG2	0.864436438045919
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/362	158/9376	1.31142037904749	ATP6V1B2/GRB2/DDIT4/SLC3A2/LPIN2/RPS6KA1/SESN2/TNF	0.791112719505985
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/362	47/9376	1.65322675443752	ALDH3A2/ALDH2/PKM	0.899656025488209
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/362	71/9376	1.45918605555988	IRF1/CGA/GRB2/FOS	0.778288876192654
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/362	28/9376	1.85003946329913	ATP6V1B2/ATP6V0D1	0.902692634429901
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	11/362	235/9376	1.21236628658752	MT-CO3/MT-ATP6/MT-ND2/MT-ND1/GRB2/MAP2K3/MT-ND5/MT-ATP8/PNPLA2/RPS6KA1/PRKACA	0.660699223438928
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/362	73/9376	1.41920835540755	MX1/MX2/AFF4/MLLT1	0.720544813293304
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/362	191/9376	1.22044488154812	FOSB/ATF4/GRB2/PRKACA/H2AC6/CALM2/GNB2/ADORA2A/GNAI2	0.616819747780156
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/362	52/9376	1.49426264343391	CGA/HSD17B1/PRKACA	0.716208504301602
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/362	75/9376	1.38136279926335	ATF4/CGA/PLCB2/PRKACA	0.664485154758994
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/362	122/9376	1.27379766325514	NFKBIA/JUN/NFKBIE/GRB2/FOS/TNF	0.609994686005189
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/362	99/9376	1.30810871142363	JUN/GRB2/FOS/CDKN1A/PRKACA	0.617588134228649
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/362	99/9376	1.30810871142363	JUN/RALGDS/GRB2/DGKZ/FOS	0.617588134228649
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/362	99/9376	1.30810871142363	ITGA5/TPM3/TGFB1/TNF/LMNA	0.617588134228649
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/362	53/9376	1.46606900865214	PLCB2/PRKACA/CLTA	0.681854113224076
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/362	243/9376	1.17245299320192	EIF4A3/CWC25/FUS/DDX39B/SRSF3/HNRNPU/RBM25/RBM8A/PRPF38B/HNRNPA3/SNRPB	0.545818549827887
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/362	31/9376	1.67100338620567	ALDH3A2/ALDH2	0.749889119901651
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/362	31/9376	1.67100338620567	ALDH3A2/ALDH2	0.749889119901651
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/362	195/9376	1.19541011474713	PLCG2/NCF1/PPIF/ITGB2/PADI4/PLCB2/GSDMD/H2AC6/C5AR1	0.552586789708635
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/362	101/9376	1.28220556862316	PLCB2/PRKACA/CALM2/GNAI2/POMC	0.571413443321795
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/362	32/9376	1.61878453038674	ATG2A/ATG3	0.702634012110078
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/362	149/9376	1.21680447921688	MT-ND2/MT-ND1/MT-ND5/PLCB2/PRKACA/GNB2/GNAI2	0.534579463806044
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/362	55/9376	1.41275740833752	PSAP/GLA/HEXB	0.615213864591568
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/362	79/9376	1.31142037904749	ATP6V1B2/NAPA/ATP6V0D1/CLTA	0.557019380236544
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/362	56/9376	1.38752959747435	GRK2/PRKACA/CSNK1G2	0.582870507544204
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/362	34/9376	1.52356191095223	CRCP/POLR2A	0.612870500502541
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/362	154/9376	1.17729784028127	ATF4/TPM3/PLCB2/KCNE1/PRKACA/CALM2/GNAI2	0.444562057166129
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/362	155/9376	1.16970237034397	ATF4/NR4A1/PLCB2/CDKN1A/PRKACA/GNAI2/POMC	0.426919402672212
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/362	254/9376	1.12167746987428	PLCG2/VEGFA/PPIF/FLT1/MCOLN1/PLCB2/ORAI2/PRKACA/PTAFR/CALM2/ADORA2A	0.393969990061329
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/362	59/9376	1.3169772450604	LAP3/MGST3/G6PD	0.489437443509299
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/362	59/9376	1.3169772450604	GRB2/GADD45B/CDKN1A	0.489437443509299
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/362	13/9376	1.99235019124522	PRKDC	0.717480775341721
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/362	108/9376	1.19909965213833	EIF4A3/DDX39B/RBM8A/UPF1/PNN	0.417033087173481
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	10/362	232/9376	1.11640312440465	FN1/ITGA5/ITGB2/ACTN4/ARHGEF1/CYFIP1/IQGAP2/ARPC1B/BAIAP2/ROCK1	0.359767284221419
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/362	158/9376	1.14749283166655	CCND3/PRKDC/YWHAE/GADD45B/TGFB1/CDKN1A/CDKN1C	0.37468150133351
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/362	134/9376	1.15972623072483	ARHGEF1/PLCB2/PRKACA/CALM2/ADORA2A/ROCK1	0.37318725794782
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/362	37/9376	1.40002986411826	GLS/ASL	0.488567119434162
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/362	62/9376	1.25325253965425	SOD2/PRKACA/SIRT1	0.4009245807897
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/362	138/9376	1.12611097766034	YWHAE/RPS6KA1/REC8/PRKACA/AURKA/CALM2	0.299078093382231
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/362	138/9376	1.12611097766034	GRB2/FLOT1/FLOT2/CBL/PRKACA/CALM2	0.299078093382231
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/362	15/9376	1.72670349907919	HEXB	0.564446656491055
NA	NA	hsa04081	Hormone signaling	9/362	219/9376	1.06440626655566	CSH1/CGA/IGF2/PLCB2/PRKACA/GNB2/GNAI2/POMC/ADIPOR2	0.19326567238627
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/362	168/9376	1.07918968692449	CSH1/CCND3/GRB2/OSM/MCL1/CDKN1A/STAT6	0.207549531861205
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/362	67/9376	1.15972623072483	ALDH3A2/ALDH2/PKM	0.262931897709725
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/362	93/9376	1.11400225747045	ACTN4/CCM2/BAIAP2/ROCK1	0.221407280167874
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	7/362	170/9376	1.06649333766656	JUN/VASP/ACTN4/PRKACA/ARPC1B/ROCK1/TUBA1B	0.175326779347052
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/362	170/9376	1.06649333766656	PLCG2/GRB2/IGF2/GADD45B/TGFB1/CDKN1A/MGST3	0.175326779347052
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/362	42/9376	1.23335964219942	NCOA4/SLC3A2	0.303736961276935
NA	NA	hsa04517	IgSF CAM signaling	12/362	299/9376	1.03948705630185	PLCG2/ITGA5/ITGB2/ICAM3/GRB2/ACTN4/INPP5D/TUBB4B/ARPC1B/ICAM1/BAIAP2/TUBA1B	0.139059393854471
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/362	17/9376	1.52356191095223	CYP27A1	0.432971118776819
Genetic Information Processing	Translation	hsa03010	Ribosome	9/362	222/9376	1.0500223980887	RPLP0/RPS9/RPS2/RPS4Y1/RPS19/RPL36A/RACK1/RPL18/RPS16	0.151152970989451
NA	NA	hsa04519	Cadherin signaling	16/362	404/9376	1.02576445489853	NFKBIA/MYO1F/KRT7/VASP/YWHAE/MAP2K3/KRT19/ACTN4/KRT18/VIM/KRT23/CYFIP1/DAAM2/DSP/ARPC1B/ROCK1	0.106083577005914
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/362	18/9376	1.43891958256599	HEXB	0.373517398574229
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/362	18/9376	1.43891958256599	PRDX1	0.373517398574229
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/362	148/9376	1.0500223980887	JUN/NFKB2/GRB2/GADD45B/FOS/CDKN1A	0.122920047518054
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/362	44/9376	1.17729784028127	HEXB/MGAT1	0.236223753037166
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/362	149/9376	1.04297526790018	PLCG2/RALGDS/GRB2/DGKZ/CYTH1/PLCB2	0.105965041654046
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/362	71/9376	1.09438954166991	GLS/PKM/G6PD	0.159983800512064
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/362	45/9376	1.15113566605279	TAP1/ABCG1	0.203652747259284
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/362	19/9376	1.36318697295725	HEXB	0.317555687078842
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/362	125/9376	1.03602209944751	CTSD/PLCB2/TNF/GNAI2/ROCK1	0.0812476547052639
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	7/362	178/9376	1.01856105282761	JUN/NOTUM/CCND3/PLCB2/DAAM2/PRKACA/SIRT1	0.0501010758633122
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/362	47/9376	1.10215116962501	TNF/PKM	0.140687616726517
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/362	48/9376	1.07918968692449	ALDH3A2/ALDH2	0.110223988620103
NA	NA	hsa03272	Virion - Hepatitis viruses	2/362	48/9376	1.07918968692449	TGOLN2/HSPG2	0.110223988620103
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/362	103/9376	1.00584669849273	COL4A1/COL18A1/SLC38A2/SLC3A2	0.0119563970141288
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/362	157/9376	0.989830031319281	CCND3/ITGB2/YWHAE/SERPINE1/BIRC3/TGFB1	-0.0257518646340841
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/362	78/9376	0.99617509562261	EXOSC4/TOB2/CNOT3	-0.00679757893298012
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/362	51/9376	1.01570794063482	LPCAT1/PLD3	0.0225403712957771
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/362	23/9376	1.12611097766034	GLS	0.12134516874741
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	12/362	323/9376	0.962249627969827	PLCG2/VEGFA/ITGA5/PLAU/GRB2/DDIT4/VIM/MCL1/CDKN1A/GLS/SIRT1/ROCK1	-0.138358990150285
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/362	80/9376	0.971270718232044	PLCG2/VEGFA/GRB2	-0.0517133713119847
NA	NA	hsa04382	Cornified envelope formation	8/362	217/9376	0.95485907783181	KRT7/PLEC/COL4A1/KRT19/ABHD5/KRT18/KRT23/DSP	-0.134820958654554
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/362	109/9376	0.95047899031882	NFKBIA/RPS6KA1/CRTC2/TNF	-0.104211177949992
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/362	83/9376	0.936164547693537	PHC2/FBRS/PHF1	-0.117058825983826
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/362	86/9376	0.903507644867018	PLCB2/GABBR1/PRKACA	-0.180142183194919
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/362	86/9376	0.903507644867018	ATF4/PLCB2/PRKACA	-0.180142183194919
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/362	86/9376	0.903507644867018	ITGA5/DSP/LMNA	-0.180142183194919
NA	NA	hsa04082	Neuroactive ligand signaling	7/362	199/9376	0.911074710569422	PLCB2/GABBR1/PRKACA/GNB2/ADORA2A/GNAI2/POMC	-0.254087094063917
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/362	115/9376	0.900888782128273	PLCB2/PRKACA/GNB2/GNAI2	-0.214300871613055
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/362	144/9376	0.899324739103745	ATG2A/PPIF/PLCB2/XBP1/ERN1	-0.243970467547188
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/362	59/9376	0.877984830040266	TYMP/CMPK2	-0.188400882981571
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/362	60/9376	0.863351749539595	PLCG2/VEGFA	-0.212787497743745
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/362	60/9376	0.863351749539595	PLCB2/GNAI2	-0.212787497743745
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/362	29/9376	0.893122499523719	CALM2	-0.115512853601309
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/362	150/9376	0.863351749539595	GRB2/RXRA/GADD45B/TGFB1/CDKN1A	-0.338083617492234
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/362	122/9376	0.849198442170093	EEF2/CRTC2/SIRT1/ADIPOR2	-0.335971270988634
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/362	122/9376	0.849198442170093	PLCG2/RXRA/PLCB2/PRKACA	-0.335971270988634
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/362	93/9376	0.835501693102834	PLCB2/PRKACA/CALM2	-0.319477206245359
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/362	31/9376	0.835501693102834	G6PD	-0.183837359274694
NA	NA	hsa04981	Folate transport and metabolism	1/362	31/9376	0.835501693102834	FOLR2	-0.183837359274694
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/362	63/9376	0.822239761466281	ALDH3A2/ALDH2	-0.283688182042854
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/362	63/9376	0.822239761466281	GADD45B/CDKN1A	-0.283688182042854
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/362	154/9376	0.840927028772332	NADK/ALDH3A2/NAPRT/ALDH2/CMPK2	-0.398864460031286
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/362	32/9376	0.80939226519337	GLA	-0.216436369801765
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/362	38/9376	0.681593486478627	TAP1	-0.394119527509854
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/362	73/9376	0.709604177703776	GADD45B/CDKN1A	-0.499138914715004
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/362	75/9376	0.690681399631676	ASL/PKM	-0.538955604565002
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/362	142/9376	0.729593027779939	UBC/UBE2S/BIRC3/CBL	-0.650651250827145
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/362	144/9376	0.719459791282996	GRB2/DUSP9/INHBA/SKIL	-0.679844534567468
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/362	44/9376	0.588648920140633	GTF2I	-0.548065874610309
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/362	82/9376	0.631720792346045	TYMP/MGST3	-0.671218532291639
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/362	117/9376	0.664116730415073	CHD4/BAZ2A/H2AC6	-0.73262276164153
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/362	83/9376	0.624109698462358	SOD2/PRDX1	-0.689292169270764
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/362	46/9376	0.563055488830171	HMOX2	-0.595313222460324
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/362	46/9376	0.563055488830171	PSMB8	-0.595313222460324
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/362	85/9376	0.60942476438089	TYMP/CMPK2	-0.724876604146319
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/362	48/9376	0.539594843462247	PLCB2	-0.640837143140134
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/362	87/9376	0.595414999682479	MT-CO3/TPM3	-0.759741883422697
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/362	90/9376	0.575567833026397	RXRA/PRKACA	-0.810767539357111
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/362	194/9376	0.667540012530615	MYO1F/TPM3/TUBB4B/DYNC1LI1/TUBA1B	-0.937675894691951
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/362	54/9376	0.47963986085533	AMD1	-0.768471027080313
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/362	56/9376	0.462509865824783	MGAT1	-0.808421213111208
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/362	57/9376	0.454395657652418	ACADVL	-0.827964538920243
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/362	61/9376	0.424599221085047	HMOX2	-0.903493598773022
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/362	370/9376	0.700014932059131	C3AR1/CSH1/CGA/LTB4R/GABBR1/PTGER4/PTAFR/C5AR1/ADORA2A/POMC	-1.17981978589954
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/362	62/9376	0.417750846551417	ADAM17	-0.921759750485539
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/362	63/9376	0.41111988073314	HPGD	-0.93979582753713
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/362	63/9376	0.41111988073314	POLR2A	-0.93979582753713
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/362	66/9376	0.392432613427089	HSD17B1	-0.992596472200765
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/362	70/9376	0.370007892659826	MGST3	-1.0601901160678
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/362	116/9376	0.446561249761859	PKM/G6PD	-1.20191626361636
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/362	73/9376	0.354802088851888	MGST3	-1.10898077871916
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/362	79/9376	0.327855094761871	MGST3	-1.20222619884425
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/362	184/9376	0.422291616622628	PLCG2/GNAI2/ROCK1	-1.58596544283109
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/362	102/9376	0.253926985158704	PLCB2	-1.51820011056648
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/362	449/9376	0.230739888518377	RGS2/GRK2/PRKACA/CALM2	-3.34753220021353